Detailed information for compound 508703

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 219.237 | Formula: C12H13NO3
  • H donors: 1 H acceptors: 2 LogP: 2.39 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(C1CCC1)O/N=C/c1ccc(cc1)O
  • InChi: 1S/C12H13NO3/c14-11-6-4-9(5-7-11)8-13-16-12(15)10-2-1-3-10/h4-8,10,14H,1-3H2/b13-8+
  • InChiKey: QXXGWJMQFQQXPJ-MDWZMJQESA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens macrophage migration inhibitory factor (glycosylation-inhibiting factor) Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium vivax macrophage migration inhibitory factor, putative Get druggable targets OG5_129767 All targets in OG5_129767
Leishmania infantum macrophage migration inhibitory factor-like protein Get druggable targets OG5_129767 All targets in OG5_129767
Giardia lamblia Macrophage migration inhibitory factor Get druggable targets OG5_129767 All targets in OG5_129767
Toxoplasma gondii macrophage migration inhibitory factor, putative Get druggable targets OG5_129767 All targets in OG5_129767
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_129767 All targets in OG5_129767
Plasmodium yoelii hypothetical protein Get druggable targets OG5_129767 All targets in OG5_129767
Leishmania mexicana macrophage migration inhibitory factor-like protein Get druggable targets OG5_129767 All targets in OG5_129767
Leishmania braziliensis macrophage migration inhibitory factor-like protein Get druggable targets OG5_129767 All targets in OG5_129767
Leishmania donovani macrophage migration inhibitory factor-like protein Get druggable targets OG5_129767 All targets in OG5_129767
Leishmania mexicana macrophage migration inhibitory factor-like protein Get druggable targets OG5_129767 All targets in OG5_129767
Leishmania infantum macrophage migration inhibitory factor-like protein Get druggable targets OG5_129767 All targets in OG5_129767
Plasmodium falciparum macrophage migration inhibitory factor Get druggable targets OG5_129767 All targets in OG5_129767
Plasmodium berghei macrophage migration inhibitory factor Get druggable targets OG5_129767 All targets in OG5_129767
Loa Loa (eye worm) macrophage migration inhibitory factor Get druggable targets OG5_129767 All targets in OG5_129767
Entamoeba histolytica macrophage migration inhibitory factor-like protein Get druggable targets OG5_129767 All targets in OG5_129767
Leishmania major macrophage migration inhibitory factor-like protein Get druggable targets OG5_129767 All targets in OG5_129767
Neospora caninum Macrophage migration inhibitory factor, related Get druggable targets OG5_129767 All targets in OG5_129767
Leishmania major macrophage migration inhibitory factor-like protein Get druggable targets OG5_129767 All targets in OG5_129767
Leishmania donovani macrophage migration inhibitory factor-like protein Get druggable targets OG5_129767 All targets in OG5_129767
Brugia malayi Bm-MIF-1, identical Get druggable targets OG5_129767 All targets in OG5_129767
Trichomonas vaginalis macrophage migration inhibitory factor, mif, putative Get druggable targets OG5_129767 All targets in OG5_129767
Plasmodium knowlesi macrophage migration inhibitory factor, putative Get druggable targets OG5_129767 All targets in OG5_129767
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0032 0.0136 0.034
Echinococcus granulosus rhodopsin orphan GPCR 0.007 0.0705 0.067
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.009 0.1013 0.0977
Loa Loa (eye worm) hypothetical protein 0.007 0.0705 0.2306
Echinococcus granulosus Ankyrin repeat domain containing protein 0.009 0.1013 0.0979
Giardia lamblia Macrophage migration inhibitory factor 0.0205 0.2769 0.5665
Echinococcus granulosus rhodopsin orphan GPCR 0.007 0.0705 0.067
Echinococcus multilocularis G-protein coupled receptor, putative 0.007 0.0705 0.067
Schistosoma mansoni opsin-like receptor 0.007 0.0705 0.0669
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0028 0.007 0.0032
Brugia malayi jmjC domain containing protein 0.0127 0.1583 0.4665
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.007 0.0705 0.067
Brugia malayi jmjC domain containing protein 0.0245 0.339 1
Echinococcus multilocularis neuropeptides capa receptor 0.007 0.0705 0.067
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0136 0.034
Loa Loa (eye worm) mbt repeat family protein 0.0047 0.0356 0.11
Echinococcus granulosus rhodopsin orphan GPCR 0.007 0.0705 0.067
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0057 0.0516 0.048
Echinococcus multilocularis biogenic amine (5HT) receptor 0.007 0.0705 0.067
Trypanosoma cruzi trypanothione reductase, putative 0.0032 0.0136 0.034
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0136 0.034
Brugia malayi larval opioid receptor 0.007 0.0705 0.2075
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.007 0.0705 0.0669
Loa Loa (eye worm) jmjC domain-containing protein 0.0118 0.1448 0.4871
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0631 0.205
Loa Loa (eye worm) thioredoxin reductase 0.0094 0.1072 0.3574
Giardia lamblia PHD finger protein 15 0.0057 0.0515 0.0991
Schistosoma mansoni amine GPCR 0.007 0.0705 0.0669
Brugia malayi Pre-SET motif family protein 0.003 0.0096 0.0277
Loa Loa (eye worm) hypothetical protein 0.007 0.0705 0.2306
Loa Loa (eye worm) hypothetical protein 0.0035 0.0181 0.0493
Echinococcus multilocularis G protein coupled receptor 139 0.007 0.0705 0.067
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0096 0.0347
Echinococcus granulosus jumonji domain containing 1A 0.0034 0.0158 0.0121
Echinococcus multilocularis rhodopsin orphan GPCR 0.007 0.0705 0.067
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0181 0.0358
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0401 0.0909
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0057 0.0516 0.1517
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0181 0.0158
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0034 0.0158 0.0416
Loa Loa (eye worm) hypothetical protein 0.0035 0.0181 0.0493
Brugia malayi neuropeptide F receptor 0.007 0.0705 0.2075
Onchocerca volvulus 0.007 0.0705 0.1917
Echinococcus granulosus tm gpcr rhodopsin 0.007 0.0705 0.067
Onchocerca volvulus 0.0237 0.3258 1
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0245 0.339 0.3365
Loa Loa (eye worm) hypothetical protein 0.007 0.0705 0.2306
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0053 0.0457 0.1449
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0032 0.0136 0.5
Schistosoma mansoni neuropeptide receptor 0.007 0.0705 0.0669
Onchocerca volvulus Heterochromatin protein 1 homolog 0.005 0.0401 0.0953
Echinococcus granulosus tm gpcr rhodopsin 0.007 0.0705 0.067
Echinococcus granulosus thyrotropin releasing hormone receptor 0.007 0.0705 0.067
Echinococcus granulosus transcription factor Dp 1 0.0038 0.0214 0.0177
Loa Loa (eye worm) hypothetical protein 0.007 0.0705 0.2306
Echinococcus multilocularis neuropeptide receptor 0.007 0.0705 0.067
Echinococcus granulosus peptide allatostatin:somatostatin 0.007 0.0705 0.067
Brugia malayi mbt repeat family protein 0.0047 0.0356 0.1045
Onchocerca volvulus 0.007 0.0705 0.1917
Echinococcus multilocularis neuropeptide receptor 0.007 0.0705 0.067
Schistosoma mansoni jumonji domain containing protein 0.0207 0.2801 0.2773
Onchocerca volvulus 0.0035 0.0181 0.0256
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0032 0.0136 0.034
Loa Loa (eye worm) hypothetical protein 0.007 0.0705 0.2306
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0591 0.0554
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0065 0.0631 0.0595
Leishmania major macrophage migration inhibitory factor-like protein 0.0205 0.2769 0.9437
Echinococcus granulosus 7TM GPCR rhodopsin 0.007 0.0705 0.067
Plasmodium falciparum thioredoxin reductase 0.0094 0.1072 0.3787
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0181 0.0141
Loa Loa (eye worm) jmjC domain-containing protein 0.0127 0.1583 0.5338
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0181 0.0358
Loa Loa (eye worm) hypothetical protein 0.0035 0.0181 0.0493
Brugia malayi neuropeptide F receptor 0.007 0.0705 0.2075
Toxoplasma gondii macrophage migration inhibitory factor, putative 0.0205 0.2769 1
Schistosoma mansoni amine GPCR 0.007 0.0705 0.0669
Entamoeba histolytica DNA repair and recombination protein RAD52, putative 0.0342 0.4859 1
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0028 0.007 0.0117
Toxoplasma gondii PHD-finger domain-containing protein 0.0057 0.0515 0.1861
Plasmodium vivax JmjC domain containing protein 0.0034 0.0158 0.0542
Brugia malayi PHD-finger family protein 0.0057 0.0515 0.1515
Loa Loa (eye worm) hypothetical protein 0.007 0.0705 0.2306
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.007 0.0705 0.2306
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0226 0.3093 0.9433
Trichomonas vaginalis phosphofructokinase, putative 0.0215 0.2932 0.7253
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.014 0.1784 0.5255
Schistosoma mansoni hypothetical protein 0.0166 0.2184 0.2153
Onchocerca volvulus Neuropeptide F receptor homolog 0.007 0.0705 0.1917
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.007 0.0705 0.2075
Leishmania major hypothetical protein, conserved 0.0034 0.0158 0.0416
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.007 0.0705 0.067
Onchocerca volvulus 0.007 0.0705 0.1917
Brugia malayi hypothetical protein 0.007 0.0705 0.2075
Brugia malayi jmjC domain containing protein 0.0034 0.0158 0.046
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.007 0.0705 0.067
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0181 0.0141
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.4028 1
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0028 0.007 0.0032
Brugia malayi hypothetical protein 0.007 0.0705 0.2075
Loa Loa (eye worm) G-protein coupled receptor 0.007 0.0705 0.2306
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0058 0.0529 0.1912
Onchocerca volvulus 0.007 0.0705 0.1917
Echinococcus granulosus chromobox protein 1 0.008 0.086 0.0826
Plasmodium vivax SET domain protein, putative 0.003 0.0096 0.0317
Echinococcus multilocularis PHD finger protein rhinoceros 0.0057 0.0515 0.0479
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0631 0.205
Trichomonas vaginalis chromobox protein, putative 0.008 0.086 0.2061
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0032 0.0136 0.034
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0215 0.2932 0.8918
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.007 0.0705 0.067
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0181 0.0141
Loa Loa (eye worm) hypothetical protein 0.007 0.0705 0.2306
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0245 0.339 0.3365
Schistosoma mansoni phd/f-box containing protein 0.0034 0.0158 0.012
Giardia lamblia Sgs1 DNA helicase, putative 0.0028 0.007 0.0067
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0181 0.0142
Loa Loa (eye worm) hypothetical protein 0.0034 0.0158 0.0416
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0214 0.2907 0.8837
Loa Loa (eye worm) RecQ helicase 0.004 0.0258 0.0761
Brugia malayi 6-phosphofructokinase 0.0215 0.2932 0.8648
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0032 0.0136 0.0464
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.009 0.1013 0.0977
Schistosoma mansoni 6-phosphofructokinase 0.0215 0.2932 0.2904
Echinococcus granulosus neuropeptides capa receptor 0.007 0.0705 0.067
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0181 0.0141
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0181 0.0493
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0052 0.0441 0.0404
Onchocerca volvulus 0.007 0.0705 0.1917
Brugia malayi beta-lactamase family protein 0.0035 0.0181 0.0527
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0214 0.2907 0.8837
Schistosoma mansoni 6-phosphofructokinase 0.0215 0.2932 0.2904
Echinococcus granulosus rhodopsin orphan GPCR 0.007 0.0705 0.067
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0136 0.034
Onchocerca volvulus 0.007 0.0705 0.1917
Echinococcus multilocularis rhodopsin orphan GPCR 0.007 0.0705 0.067
Trichomonas vaginalis phosphofructokinase, putative 0.0215 0.2932 0.7253
Loa Loa (eye worm) hypothetical protein 0.005 0.0401 0.1253
Schistosoma mansoni rhodopsin-like orphan GPCR 0.007 0.0705 0.0669
Toxoplasma gondii phosphofructokinase PFKII 0.0058 0.0529 0.1912
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0032 0.0136 0.034
Brugia malayi hypothetical protein 0.007 0.0705 0.2075
Echinococcus multilocularis neuropeptide s receptor 0.0522 0.7612 0.7603
Giardia lamblia NADH oxidase lateral transfer candidate 0.0032 0.0136 0.0204
Trichomonas vaginalis phosphofructokinase, putative 0.0058 0.0529 0.1232
Echinococcus multilocularis neuropeptide Y receptor 0.007 0.0705 0.067
Loa Loa (eye worm) hypothetical protein 0.007 0.0705 0.2306
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0215 0.2932 1
Echinococcus granulosus G protein coupled receptor 139 0.007 0.0705 0.067
Brugia malayi Heterochromatin protein 1 0.008 0.086 0.2533
Echinococcus granulosus g protein coupled receptor 0.007 0.0705 0.067
Echinococcus multilocularis allatostatin A receptor 0.007 0.0705 0.067
Trichomonas vaginalis macrophage migration inhibitory factor, mif, putative 0.0205 0.2769 0.6845
Brugia malayi jmjC domain containing protein 0.0034 0.0158 0.046
Brugia malayi G-protein coupled receptor 0.007 0.0705 0.2075
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0215 0.2932 1
Loa Loa (eye worm) hypothetical protein 0.007 0.0705 0.2306
Echinococcus granulosus geminin 0.0166 0.2184 0.2154
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.007 0.0705 0.1917
Loa Loa (eye worm) hypothetical protein 0.007 0.0705 0.2306
Plasmodium vivax thioredoxin reductase, putative 0.0094 0.1072 0.3853
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0053 0.0455 0.0419
Trichomonas vaginalis phosphofructokinase, putative 0.0058 0.0529 0.1232
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0065 0.0631 0.205
Echinococcus multilocularis phd:f box containing protein 0.0034 0.0158 0.0121
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0032 0.0136 0.0396
Schistosoma mansoni growth hormone secretagogue receptor 0.007 0.0705 0.0669
Trichomonas vaginalis chromobox protein, putative 0.0053 0.0445 0.1021
Echinococcus granulosus neuropeptide FF receptor 2 0.007 0.0705 0.067
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0028 0.007 0.0252
Brugia malayi Dopamine receptor 0.007 0.0705 0.2075
Trichomonas vaginalis glutathione reductase, putative 0.0032 0.0136 0.0247
Echinococcus granulosus biogenic amine 5HT receptor 0.007 0.0705 0.067
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0188 0.2519 0.2491
Echinococcus granulosus orexin receptor type 2 0.007 0.0705 0.067
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0057 0.0516 0.1359
Brugia malayi Pre-SET motif family protein 0.0208 0.2818 0.8313
Brugia malayi putative neuropeptide receptor 0.007 0.0705 0.2075
Schistosoma mansoni hypothetical protein 0.007 0.0705 0.0669
Onchocerca volvulus 0.0112 0.1358 0.3984
Schistosoma mansoni protein phosphatase 2C 0.0034 0.0158 0.012
Loa Loa (eye worm) hypothetical protein 0.007 0.0705 0.2306
Mycobacterium tuberculosis Probable reductase 0.0214 0.2907 0.8837
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0181 0.0142
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.007 0.0705 0.2075
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0032 0.0136 0.0098
Loa Loa (eye worm) hypothetical protein 0.003 0.0096 0.0201
Onchocerca volvulus 0.007 0.0705 0.1917
Echinococcus granulosus rhodopsin orphan GPCR 0.007 0.0705 0.067
Schistosoma mansoni microtubule-associated protein tau 0.0678 1 1
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.007 0.0705 0.067
Loa Loa (eye worm) jmjC domain-containing protein 0.0034 0.0158 0.0416
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0065 0.0631 0.0596
Onchocerca volvulus 0.007 0.0705 0.1917
Schistosoma mansoni biogenic amine receptor 0.007 0.0705 0.0669
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0591 0.0554
Schistosoma mansoni neuropeptide F-like receptor 0.007 0.0705 0.0669
Trichomonas vaginalis phosphofructokinase, putative 0.0058 0.0529 0.1232
Echinococcus granulosus allatostatin A receptor 0.007 0.0705 0.067
Brugia malayi hypothetical protein 0.007 0.0705 0.2075
Loa Loa (eye worm) hypothetical protein 0.007 0.0705 0.2306
Schistosoma mansoni myelin transcription factor 1 myt1 0.0053 0.0455 0.0418
Schistosoma mansoni biogenic amine receptor 0.007 0.0705 0.0669
Schistosoma mansoni myosin xvIII 0.007 0.0705 0.0669
Brugia malayi putative neuropeptide receptor NPR1 0.007 0.0705 0.2075
Trichomonas vaginalis DNA helicase recq, putative 0.004 0.0258 0.0552
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.007 0.0705 0.2075
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0034 0.0158 0.0571
Schistosoma mansoni jumonji/arid domain-containing protein 0.0127 0.1583 0.155
Brugia malayi Dopamine receptor protein 2 0.007 0.0705 0.2075
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0181 0.0141
Echinococcus granulosus biogenic amine 5HT receptor 0.007 0.0705 0.067
Echinococcus multilocularis chromobox protein 1 0.008 0.086 0.0826
Treponema pallidum fructose-bisphosphate aldolase 0.0287 0.4028 1
Echinococcus multilocularis g protein coupled receptor 0.007 0.0705 0.067
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0058 0.0529 0.18
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.007 0.0705 0.067
Echinococcus granulosus g protein coupled receptor 0.007 0.0705 0.067
Echinococcus granulosus histone acetyltransferase MYST2 0.0053 0.0455 0.0419
Giardia lamblia Fructose-bisphosphate aldolase 0.0287 0.4028 0.8276
Loa Loa (eye worm) G-protein coupled receptor 0.007 0.0705 0.2306
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0032 0.0136 0.034
Echinococcus multilocularis lysine specific demethylase 6a 0.0034 0.0158 0.0121
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0038 0.0219 0.0664
Echinococcus multilocularis neuropeptide Y receptor 0.007 0.0705 0.067
Echinococcus granulosus JmjC domain containing protein 4 0.0034 0.0158 0.0121
Giardia lamblia DNA repair protein RAD52 0.0342 0.4859 1
Plasmodium falciparum thioredoxin reductase 0.0032 0.0136 0.0361
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.007 0.0705 0.0669
Echinococcus multilocularis Ankyrin repeat domain containing protein 0.009 0.1013 0.0979
Schistosoma mansoni biogenic amine (5HT) receptor 0.007 0.0705 0.0669
Echinococcus multilocularis sex peptide receptor 0.007 0.0705 0.067
Loa Loa (eye worm) macrophage migration inhibitory factor 2 0.0087 0.0975 0.3238
Brugia malayi hypothetical protein 0.007 0.0705 0.2075
Echinococcus granulosus sex peptide receptor 0.007 0.0705 0.067
Echinococcus granulosus g protein coupled receptor 0.007 0.0705 0.067
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0065 0.0631 0.1231
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.014 0.1784 0.5187
Trichomonas vaginalis phosphofructokinase, putative 0.0058 0.0529 0.1232
Schistosoma mansoni amine GPCR 0.007 0.0705 0.0669
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0058 0.0529 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.0158 0.0416
Schistosoma mansoni DNA helicase recq1 0.0028 0.007 0.0031
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.4028 1
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.007 0.0705 0.2306
Loa Loa (eye worm) hypothetical protein 0.007 0.0705 0.2306
Echinococcus granulosus serotonin receptor 0.007 0.0705 0.067
Echinococcus granulosus PHD finger protein rhinoceros 0.0057 0.0515 0.0479
Loa Loa (eye worm) hypothetical protein 0.007 0.0705 0.2306
Loa Loa (eye worm) glutathione reductase 0.0094 0.1072 0.3574
Echinococcus multilocularis jumonji domain containing protein 0.008 0.0858 0.0824
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0047 0.0356 0.0812
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0238 0.3271 1
Echinococcus multilocularis 6 phosphofructokinase 0.0215 0.2932 0.2905
Entamoeba histolytica hypothetical protein 0.0097 0.1125 0.2255
Loa Loa (eye worm) hypothetical protein 0.007 0.0705 0.2306
Leishmania major ATP-dependent phosphofructokinase 0.0215 0.2932 1
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0181 0.0141
Brugia malayi Thioredoxin reductase 0.0094 0.1072 0.3158
Schistosoma mansoni neuropeptide F-like receptor 0.007 0.0705 0.0669
Echinococcus multilocularis serotonin receptor 0.007 0.0705 0.067
Echinococcus multilocularis tachykinin peptides receptor 99D 0.007 0.0705 0.067
Echinococcus multilocularis lysine specific demethylase 5A 0.0127 0.1583 0.1551
Plasmodium falciparum glutathione reductase 0.0032 0.0136 0.0361
Onchocerca volvulus 0.007 0.0705 0.1917
Echinococcus multilocularis fmrfamide receptor 0.007 0.0705 0.067
Echinococcus multilocularis JmjC domain containing protein 4 0.0034 0.0158 0.0121
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0188 0.2519 0.2491
Loa Loa (eye worm) hypothetical protein 0.007 0.0705 0.2306
Schistosoma mansoni jumonji domain containing protein 0.0034 0.0158 0.012
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0215 0.2932 0.7184
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0032 0.0136 0.0361
Schistosoma mansoni biogenic amine (dopamine) receptor 0.007 0.0705 0.0669
Loa Loa (eye worm) neuropeptide F receptor 0.007 0.0705 0.2306
Echinococcus multilocularis transcription factor Dp 1 0.0038 0.0214 0.0177
Loa Loa (eye worm) hypothetical protein 0.0027 0.0047 0.0033
Loa Loa (eye worm) hypothetical protein 0.007 0.0705 0.2306
Brugia malayi chromobox protein homolog 3 0.005 0.0401 0.1176
Loa Loa (eye worm) hypothetical protein 0.0028 0.007 0.0111
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0065 0.0631 0.0596
Loa Loa (eye worm) hypothetical protein 0.0114 0.1376 0.4625
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0096 0.0057
Mycobacterium ulcerans beta-lactamase 0.0035 0.0181 0.0158
Echinococcus multilocularis g protein coupled receptor 0.007 0.0705 0.067
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0591 0.0555
Brugia malayi 6-phosphofructokinase 0.0215 0.2932 0.8648
Echinococcus granulosus phd:f box containing protein 0.0034 0.0158 0.0121
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0181 0.0158
Schistosoma mansoni biogenic amine (5HT) receptor 0.007 0.0705 0.0669
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.007 0.0705 0.067
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0208 0.2818 0.9608
Brugia malayi Dopamine receptor protein 1 0.007 0.0705 0.2075
Loa Loa (eye worm) hypothetical protein 0.007 0.0705 0.2306
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0096 0.0058
Brugia malayi M-phase phosphoprotein, mpp8 0.0112 0.1358 0.4002
Brugia malayi Bloom's syndrome protein homolog 0.004 0.0258 0.0755
Plasmodium falciparum phd finger protein, putative 0.0057 0.0515 0.1749
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0028 0.007 0.0032
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0058 0.0529 0.102
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0065 0.0631 0.1856
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0031 0.0109 0.0245
Trichomonas vaginalis chromobox protein, putative 0.008 0.086 0.2061
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0058 0.0529 0.102
Brugia malayi RE15519p 0.007 0.0705 0.2075
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.007 0.0705 0.067
Echinococcus granulosus tachykinin peptides receptor 99D 0.007 0.0705 0.067
Echinococcus granulosus tar DNA binding protein 0.0062 0.0591 0.0555
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0028 0.007 0.0032
Schistosoma mansoni DNA helicase recq5 0.0028 0.007 0.0031
Echinococcus granulosus hypothetical protein 0.007 0.0705 0.067
Entamoeba histolytica phosphofructokinase, putative 0.0215 0.2932 0.6003
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0024 0.0005 0.0007
Echinococcus granulosus neuropeptide s receptor 0.0522 0.7612 0.7603
Loa Loa (eye worm) jmjC domain-containing protein 0.0034 0.0158 0.0416
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0058 0.0529 0.18
Brugia malayi Bromodomain containing protein 0.0057 0.0515 0.1515
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0032 0.0136 0.0099
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.007 0.0705 0.067
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0591 0.1912
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0032 0.0136 0.5
Echinococcus granulosus lysine specific demethylase 5A 0.0127 0.1583 0.1551
Schistosoma mansoni amine GPCR 0.007 0.0705 0.0669
Brugia malayi G protein-coupled receptor F59B2.13 0.007 0.0705 0.2075
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0181 0.0358
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0055 0.0044
Schistosoma mansoni rhodopsin-like orphan GPCR 0.007 0.0705 0.0669
Onchocerca volvulus Alhambra homolog 0.0057 0.0515 0.1316
Plasmodium vivax 6-phosphofructokinase, putative 0.0058 0.0529 0.1887
Echinococcus multilocularis thioredoxin glutathione reductase 0.0094 0.1072 0.1038
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0136 0.034
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0238 0.3271 1
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0214 0.2907 0.8821
Echinococcus multilocularis geminin 0.0166 0.2184 0.2154
Schistosoma mansoni rhodopsin-like orphan GPCR 0.007 0.0705 0.0669
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0034 0.0158 0.0121
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.007 0.0705 0.067
Schistosoma mansoni neuropeptide receptor 0.007 0.0705 0.0669
Loa Loa (eye worm) 6-phosphofructokinase 0.0215 0.2932 1
Loa Loa (eye worm) hypothetical protein 0.007 0.0705 0.2306
Loa Loa (eye worm) phosphofructokinase 0.0215 0.2932 1
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0028 0.007 0.02
Toxoplasma gondii 6-phosphofructokinase 0.0058 0.0529 0.1912
Entamoeba histolytica macrophage migration inhibitory factor-like protein 0.0205 0.2769 0.5665
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0079 0.0042
Loa Loa (eye worm) hypothetical protein 0.007 0.0705 0.2306
Echinococcus multilocularis rhodopsin orphan GPCR 0.007 0.0705 0.067
Schistosoma mansoni phosphatidylserine receptor 0.0034 0.0158 0.012
Echinococcus multilocularis polycomb protein SCMH1 0.0047 0.0356 0.032
Toxoplasma gondii NADPH-glutathione reductase 0.0032 0.0136 0.0492
Loa Loa (eye worm) hypothetical protein 0.007 0.0705 0.2306
Loa Loa (eye worm) hypothetical protein 0.007 0.0705 0.2306
Trichomonas vaginalis mercuric reductase, putative 0.0032 0.0136 0.0247
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0057 0.0515 0.0478
Trichomonas vaginalis DNA helicase recq, putative 0.0031 0.0109 0.0178
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.007 0.0705 0.0669
Loa Loa (eye worm) hypothetical protein 0.007 0.0705 0.2306
Brugia malayi G protein-coupled receptor 0.007 0.0705 0.2075
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0032 0.0136 0.0361
Schistosoma mansoni neuropeptide f receptor 76f 0.007 0.0705 0.0669
Echinococcus granulosus SAM and MBT domain containing protein 0.0047 0.0356 0.032
Trichomonas vaginalis set domain proteins, putative 0.0237 0.3258 0.8069
Loa Loa (eye worm) hypothetical protein 0.0035 0.0181 0.0493
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0034 0.0158 0.0121
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0356 0.0319
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0181 0.0493
Schistosoma mansoni hypothetical protein 0.007 0.0705 0.0669
Echinococcus granulosus neuropeptide Y receptor 0.007 0.0705 0.067
Brugia malayi hypothetical protein 0.007 0.0705 0.2075
Loa Loa (eye worm) hypothetical protein 0.007 0.0705 0.2306
Toxoplasma gondii thioredoxin reductase 0.0094 0.1072 0.3872
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0055 0.0044
Schistosoma mansoni hypothetical protein 0.0057 0.0515 0.0478
Plasmodium falciparum glutathione reductase 0.0094 0.1072 0.3787
Brugia malayi gonadotropin-releasing hormone receptor 2 0.007 0.0705 0.2075
Schistosoma mansoni hypothetical protein 0.0289 0.405 0.4027
Loa Loa (eye worm) hypothetical protein 0.007 0.0705 0.2306
Echinococcus granulosus dro:myosuppressin receptor 0.007 0.0705 0.067
Echinococcus granulosus peregrin 0.0057 0.0515 0.0479
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0026 0.0038 0.0136
Schistosoma mansoni histamine h1 receptor 0.007 0.0705 0.0669
Loa Loa (eye worm) hypothetical protein 0.007 0.0705 0.2306
Echinococcus granulosus neuropeptides capa receptor 0.007 0.0705 0.067
Echinococcus multilocularis jumonji domain containing 1A 0.0034 0.0158 0.0121
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.007 0.0705 0.0669
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0181 0.0143
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0181 0.0143
Onchocerca volvulus 0.0047 0.0356 0.0812
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0057 0.0516 0.0479
Loa Loa (eye worm) hypothetical protein 0.007 0.0705 0.2306
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0034 0.0158 0.0571
Schistosoma mansoni biogenic amine receptor 0.007 0.0705 0.0669
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.007 0.0705 0.067
Schistosoma mansoni neuropeptide receptor 0.007 0.0705 0.0669
Schistosoma mansoni jumonji/arid domain-containing protein 0.0127 0.1583 0.155
Entamoeba histolytica recQ family helicase, putative 0.0031 0.0109 0.0147
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.007 0.0705 0.067
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.4028 1
Echinococcus granulosus rhodopsin orphan GPCR 0.007 0.0705 0.067
Brugia malayi jmjC domain containing protein 0.0034 0.0158 0.046
Trypanosoma cruzi trypanothione reductase, putative 0.0094 0.1072 0.3574
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0136 0.034
Echinococcus granulosus lysine specific demethylase 6a 0.0034 0.0158 0.0121
Schistosoma mansoni rhodopsin-like orphan GPCR 0.007 0.0705 0.0669
Loa Loa (eye worm) hypothetical protein 0.0057 0.0515 0.165
Mycobacterium tuberculosis Conserved protein 0.0035 0.0181 0.0141
Loa Loa (eye worm) hypothetical protein 0.007 0.0705 0.2306
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.007 0.0705 0.067
Onchocerca volvulus 0.007 0.0705 0.1917
Echinococcus multilocularis microtubule associated protein 2 0.0678 1 1
Brugia malayi Serotonin receptor 0.007 0.0705 0.2075
Loa Loa (eye worm) hypothetical protein 0.007 0.0705 0.2306
Onchocerca volvulus 0.0035 0.0181 0.0256
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.007 0.0705 0.2306
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0057 0.0516 0.048
Schistosoma mansoni rhodopsin-like orphan GPCR 0.007 0.0705 0.0669
Schistosoma mansoni peptide (allatostatin)-like receptor 0.007 0.0705 0.0669
Trypanosoma brucei trypanothione reductase 0.0094 0.1072 0.3574
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0028 0.007 0.0111
Loa Loa (eye worm) hypothetical protein 0.0035 0.0181 0.0493
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0287 0.4028 0.8276
Brugia malayi Melatonin receptor type 1A 0.007 0.0705 0.2075
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0058 0.0529 1
Echinococcus granulosus bloom syndrome protein 0.004 0.0258 0.0221
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0032 0.0136 0.034
Trichomonas vaginalis phosphofructokinase, putative 0.0215 0.2932 0.7253
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0024 0.0005 0.0007
Brugia malayi hypothetical protein 0.007 0.0705 0.2075
Trichomonas vaginalis esterase, putative 0.0035 0.0181 0.0358
Echinococcus multilocularis fmrfamide receptor 0.007 0.0705 0.067
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0591 0.1738
Loa Loa (eye worm) hypothetical protein 0.007 0.0705 0.2306
Onchocerca volvulus 0.007 0.0705 0.1917
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0032 0.0136 0.034
Echinococcus granulosus rhodopsin orphan GPCR 0.007 0.0705 0.067
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0028 0.007 0.02
Echinococcus granulosus somatostatin receptor 0.007 0.0705 0.067
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0631 0.205
Echinococcus multilocularis g protein coupled receptor 0.007 0.0705 0.067
Loa Loa (eye worm) hypothetical protein 0.0047 0.0356 0.11
Toxoplasma gondii PHD-finger domain-containing protein 0.0057 0.0515 0.1861
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0032 0.0136 0.034
Brugia malayi Serotonin receptor 0.007 0.0705 0.2075
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0032 0.0136 0.0464
Brugia malayi ORL1-like opioid receptor 0.007 0.0705 0.2075
Loa Loa (eye worm) hypothetical protein 0.007 0.0705 0.2306
Plasmodium falciparum JmjC domain-containing protein, putative 0.0034 0.0158 0.044
Loa Loa (eye worm) melatonin receptor type 1A 0.007 0.0705 0.2306
Echinococcus granulosus expressed protein 0.0373 0.534 0.5323
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0057 0.0516 0.1212
Schistosoma mansoni chromobox protein 0.008 0.086 0.0824
Brugia malayi mbt repeat family protein 0.0047 0.0356 0.1045
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0058 0.0529 0.1232
Echinococcus multilocularis neuropeptide FF receptor 2 0.007 0.0705 0.067
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0591 0.0554
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0032 0.0136 0.0492
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0031 0.0109 0.0245
Schistosoma mansoni biogenic amine (dopamine) receptor 0.007 0.0705 0.0669
Echinococcus multilocularis histone acetyltransferase MYST2 0.0053 0.0455 0.0419
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0356 0.0319
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0028 0.007 0.0252
Echinococcus granulosus thioredoxin glutathione reductase 0.0094 0.1072 0.1038
Echinococcus multilocularis rhodopsin orphan GPCR 0.007 0.0705 0.067
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0591 0.0554
Mycobacterium tuberculosis Conserved protein 0.0035 0.0181 0.0141
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0287 0.4028 0.8276
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.007 0.0705 0.067
Echinococcus multilocularis neuropeptide receptor A26 0.0522 0.7612 0.7603
Trichomonas vaginalis phosphofructokinase, putative 0.0058 0.0529 0.1232
Brugia malayi hypothetical protein 0.007 0.0705 0.2075
Mycobacterium ulcerans lipase LipD 0.0035 0.0181 0.0158
Echinococcus granulosus chromobox protein 1 0.008 0.086 0.0826
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.007 0.0705 0.0669
Loa Loa (eye worm) beta-lactamase 0.0035 0.0181 0.0493
Mycobacterium tuberculosis Probable dehydrogenase 0.0214 0.2907 0.8837
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0096 0.0057
Echinococcus granulosus 7tm_1 domain containing protein 0.007 0.0705 0.067
Echinococcus granulosus tm gpcr rhodopsin 0.007 0.0705 0.067
Loa Loa (eye worm) hypothetical protein 0.003 0.01 0.0214
Loa Loa (eye worm) hypothetical protein 0.007 0.0705 0.2306
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.007 0.0705 0.0669
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0065 0.0631 0.205
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0034 0.0158 0.0416
Echinococcus multilocularis peregrin 0.0057 0.0515 0.0479
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0047 0.0356 0.0319
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0096 0.0058
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.007 0.0705 0.2306
Echinococcus multilocularis somatostatin receptor 0.007 0.0705 0.067
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0181 0.0624
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0591 0.0554
Echinococcus multilocularis rhodopsin orphan GPCR 0.007 0.0705 0.067
Brugia malayi AKH receptor 0.007 0.0705 0.2075
Echinococcus multilocularis rhodopsin orphan GPCR 0.007 0.0705 0.067
Brugia malayi RNA binding protein 0.0062 0.0591 0.1738
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0181 0.0358
Echinococcus granulosus alpha 1A adrenergic receptor 0.007 0.0705 0.067
Echinococcus multilocularis alpha 1A adrenergic receptor 0.007 0.0705 0.067
Loa Loa (eye worm) hypothetical protein 0.0053 0.0455 0.1443
Echinococcus multilocularis expressed protein 0.0373 0.534 0.5323
Onchocerca volvulus 0.007 0.0705 0.1917
Mycobacterium ulcerans 6-phosphofructokinase 0.0215 0.2932 1
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0053 0.0445 0.1094
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0057 0.0516 0.1359
Loa Loa (eye worm) heterochromatin protein 1 0.008 0.086 0.2842
Echinococcus multilocularis chromobox protein 1 0.008 0.086 0.0826
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.4028 1
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0032 0.0136 0.034
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0214 0.2907 0.8837
Loa Loa (eye worm) hypothetical protein 0.0112 0.1358 0.4561
Plasmodium vivax 6-phosphofructokinase, putative 0.0058 0.0529 0.1887
Echinococcus granulosus polycomb protein SCMH1 0.0047 0.0356 0.032
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0032 0.0136 0.0099
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.007 0.0705 0.067
Schistosoma mansoni opsin-like receptor 0.007 0.0705 0.0669
Brugia malayi jmjC domain containing protein 0.0034 0.0158 0.046
Echinococcus multilocularis rhodopsin orphan GPCR 0.007 0.0705 0.067
Brugia malayi phosphofructokinase 0.0215 0.2932 0.8648
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0181 0.0358
Entamoeba histolytica phosphofructokinase, putative 0.0215 0.2932 0.6003
Schistosoma mansoni chromobox protein 0.008 0.086 0.0824
Loa Loa (eye worm) 6-phosphofructokinase 0.0215 0.2932 1
Trichomonas vaginalis chromobox protein, putative 0.0053 0.0445 0.1021
Onchocerca volvulus 0.0052 0.0441 0.1082
Brugia malayi beta-lactamase family protein 0.0035 0.0181 0.0527
Plasmodium vivax macrophage migration inhibitory factor, putative 0.0205 0.2769 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0096 0.0057
Schistosoma mansoni adenoreceptor 0.007 0.0705 0.0669
Onchocerca volvulus 0.0112 0.1358 0.3984
Trichomonas vaginalis DNA helicase recq1, putative 0.004 0.0258 0.0552
Brugia malayi TAR-binding protein 0.0062 0.0591 0.1738
Onchocerca volvulus 0.007 0.0705 0.1917
Echinococcus multilocularis neuropeptides capa receptor 0.007 0.0705 0.067
Schistosoma mansoni hypothetical protein 0.007 0.0705 0.0669
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0181 0.0141
Loa Loa (eye worm) PHD-finger family protein 0.0057 0.0515 0.165
Echinococcus multilocularis dro:myosuppressin receptor 0.007 0.0705 0.067
Schistosoma mansoni biogenic amine (dopamine) receptor 0.007 0.0705 0.0669
Loa Loa (eye worm) hypothetical protein 0.007 0.0705 0.2306
Schistosoma mansoni hypothetical protein 0.007 0.0705 0.0669
Toxoplasma gondii ABC1 family protein 0.0035 0.0181 0.0652
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.4028 1
Loa Loa (eye worm) MBCTL1 0.0053 0.0455 0.1443
Plasmodium vivax hypothetical protein, conserved 0.0057 0.0515 0.1837
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0057 0.0516 0.1653
Loa Loa (eye worm) hypothetical protein 0.007 0.0705 0.2306
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0096 0.0058
Trichomonas vaginalis phosphofructokinase, putative 0.0058 0.0529 0.1232
Brugia malayi Flap endonuclease-1 0.0026 0.0038 0.0105
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0238 0.3271 1
Onchocerca volvulus 0.0035 0.0181 0.0256
Loa Loa (eye worm) hypothetical protein 0.007 0.0705 0.2306
Onchocerca volvulus 0.007 0.0705 0.1917
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0034 0.0158 0.012
Echinococcus multilocularis g-protein coupled receptor 0.007 0.0705 0.067
Loa Loa (eye worm) TYRA-2 protein 0.007 0.0705 0.2306
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0058 0.0529 0.101
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0053 0.0455 0.0419
Echinococcus granulosus neuropeptide receptor 0.007 0.0705 0.067
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.4028 1
Loa Loa (eye worm) neuropeptide F receptor 0.007 0.0705 0.2306
Schistosoma mansoni amine GPCR 0.007 0.0705 0.0669
Loa Loa (eye worm) hypothetical protein 0.007 0.0705 0.2306
Brugia malayi follicle stimulating hormone receptor 0.007 0.0705 0.2075
Plasmodium vivax glutathione reductase, putative 0.0094 0.1072 0.3853
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.014 0.1784 0.5892
Loa Loa (eye worm) hypothetical protein 0.007 0.0705 0.2306
Leishmania major trypanothione reductase 0.0094 0.1072 0.3574
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0215 0.2932 0.8902
Loa Loa (eye worm) hypothetical protein 0.007 0.0705 0.2306
Echinococcus granulosus fmrfamide receptor 0.007 0.0705 0.067
Loa Loa (eye worm) jmjC domain-containing protein 0.0034 0.0158 0.0416
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0181 0.0493
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0181 0.0527
Echinococcus granulosus jumonji domain containing protein 0.008 0.0858 0.0824
Schistosoma mansoni rhodopsin-like orphan GPCR 0.007 0.0705 0.0669
Schistosoma mansoni rhodopsin-like orphan GPCR 0.007 0.0705 0.0669
Loa Loa (eye worm) hypothetical protein 0.0112 0.1358 0.4561
Brugia malayi hypothetical protein 0.007 0.0705 0.2075
Echinococcus granulosus 6 phosphofructokinase 0.0215 0.2932 0.2905
Echinococcus multilocularis bloom syndrome protein 0.004 0.0258 0.0221
Plasmodium vivax flap endonuclease 1, putative 0.0026 0.0038 0.0107
Trichomonas vaginalis conserved hypothetical protein 0.0205 0.2769 0.6845
Brugia malayi hypothetical protein 0.007 0.0705 0.2075
Schistosoma mansoni neuropeptide receptor 0.007 0.0705 0.0669
Brugia malayi beta-lactamase 0.0035 0.0181 0.0527
Loa Loa (eye worm) hypothetical protein 0.007 0.0705 0.2306
Loa Loa (eye worm) hypothetical protein 0.007 0.0705 0.2306
Loa Loa (eye worm) macrophage migration inhibitory factor 2 0.0087 0.0975 0.3238
Onchocerca volvulus 0.007 0.0705 0.1917
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0401 0.0909
Loa Loa (eye worm) hypothetical protein 0.007 0.0705 0.2306
Loa Loa (eye worm) hypothetical protein 0.007 0.0705 0.2306
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0214 0.2907 0.8837
Loa Loa (eye worm) hypothetical protein 0.0035 0.0181 0.0493
Loa Loa (eye worm) RNA binding protein 0.0062 0.0591 0.1912
Loa Loa (eye worm) hypothetical protein 0.007 0.0705 0.2306
Schistosoma mansoni hypothetical protein 0.0166 0.2184 0.2153
Trichomonas vaginalis phosphofructokinase, putative 0.0215 0.2932 0.7253
Leishmania major macrophage migration inhibitory factor-like protein 0.0205 0.2769 0.9437
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0034 0.0158 0.0416
Echinococcus multilocularis serotonin receptor 0.007 0.0705 0.067
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0032 0.0136 0.034
Echinococcus granulosus neuropeptide receptor A26 0.0522 0.7612 0.7603
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.007 0.0705 0.067
Brugia malayi Serotonin/octopamine receptor family protein 7 0.007 0.0705 0.2075
Loa Loa (eye worm) hypothetical protein 0.007 0.0705 0.2306
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.007 0.0705 0.0669
Onchocerca volvulus 0.007 0.0705 0.1917
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0053 0.0455 0.1337
Schistosoma mansoni alpha-1 adrenergic receptor 0.007 0.0705 0.0669
Brugia malayi glutathione reductase 0.0094 0.1072 0.3158
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0136 0.034
Plasmodium falciparum macrophage migration inhibitory factor 0.0205 0.2769 1
Entamoeba histolytica Rad52/22 family double-strand break repair protein, putative 0.0097 0.1125 0.2255
Mycobacterium ulcerans hypothetical protein 0.0035 0.0181 0.0158
Onchocerca volvulus 0.007 0.0705 0.1917
Brugia malayi GnHR receptor homolog 0.007 0.0705 0.2075
Brugia malayi Bm-MIF-1, identical 0.0205 0.2769 0.8167
Brugia malayi Tachykinin-like peptides receptor 99D 0.007 0.0705 0.2075
Brugia malayi sulfakinin receptor protein 0.007 0.0705 0.2075
Schistosoma mansoni rhodopsin-like orphan GPCR 0.007 0.0705 0.0669
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.007 0.0705 0.0669
Schistosoma mansoni opsin-like receptor 0.007 0.0705 0.0669
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0031 0.0109 0.0245
Echinococcus granulosus neuropeptide receptor 0.007 0.0705 0.067
Loa Loa (eye worm) hypothetical protein 0.007 0.0705 0.2306
Echinococcus granulosus g-protein coupled receptor 0.007 0.0705 0.067
Leishmania major hypothetical protein, conserved 0.0035 0.0181 0.0493
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.4028 1
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0181 0.0493
Brugia malayi G-protein coupled receptor 0.007 0.0705 0.2075
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0591 0.1912
Echinococcus multilocularis SAM and MBT domain containing protein 0.0047 0.0356 0.032
Schistosoma mansoni rhodopsin-like orphan GPCR 0.007 0.0705 0.0669
Echinococcus granulosus neuropeptide Y receptor 0.007 0.0705 0.067
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0094 0.1072 0.2985
Echinococcus multilocularis rhodopsin orphan GPCR 0.007 0.0705 0.067
Mycobacterium tuberculosis Conserved protein 0.0035 0.0181 0.0141
Brugia malayi hypothetical protein 0.0112 0.1358 0.4002
Mycobacterium tuberculosis Probable oxidoreductase 0.0238 0.3271 1
Entamoeba histolytica phosphofructokinase, putative 0.0215 0.2932 0.6003
Loa Loa (eye worm) macrophage migration inhibitory factor 0.0205 0.2769 0.9437
Echinococcus multilocularis orexin receptor type 2 0.007 0.0705 0.067
Loa Loa (eye worm) follicle stimulating hormone receptor 0.007 0.0705 0.2306
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.007 0.0705 0.0669
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.4028 1

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 11 uM Inhibition of MIF (unknown origin)-mediated dopachrome tautomerase activity ChEMBL. 17526494
IC50 (binding) = 11 uM Inhibition of MIF (unknown origin)-mediated dopachrome tautomerase activity ChEMBL. 17526494

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.