Detailed information for compound 515522

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 380.43 | Formula: C23H22F2N2O
  • H donors: 1 H acceptors: 1 LogP: 4.74 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1ccc2c(c1)ccc(c2)CN1CCC(CC1)NC(=O)c1ccccc1F
  • InChi: 1S/C23H22F2N2O/c24-19-8-7-17-13-16(5-6-18(17)14-19)15-27-11-9-20(10-12-27)26-23(28)21-3-1-2-4-22(21)25/h1-8,13-14,20H,9-12,15H2,(H,26,28)
  • InChiKey: PGBWNUGAHUIGEF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens chemokine (C-C motif) receptor 3 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi solanesyl-diphosphate synthase, putative 0.0319 0.2422 0.2421
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0018 0.0007 0.0006
Toxoplasma gondii polyprenyl synthetase superfamily protein 0.0319 0.2422 0.2231
Echinococcus multilocularis dna polymerase kappa 0.0048 0.0251 0.025
Trypanosoma brucei rac serine-threonine kinase, putative 0.0049 0.0258 0.0258
Schistosoma mansoni trans-prenyltransferase 0.0319 0.2422 0.2421
Plasmodium vivax geranylgeranyl pyrophosphate synthase 0.1263 1 1
Trichomonas vaginalis AGC family protein kinase 0.0049 0.0258 0.0252
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0032 0.0118 0.0118
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0018 0.0007 0.0007
Loa Loa (eye worm) AGC/PKN protein kinase 0.0018 0.0007 0.0007
Echinococcus multilocularis protein kinase shaggy 0.0056 0.0316 0.0316
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.0189 0.0188
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0018 0.0007 0.0006
Mycobacterium ulcerans polyprenyl diphosphate synthetase, GrcC1 0.0319 0.2422 0.2227
Echinococcus granulosus geranylgeranyl pyrophosphate synthase 0.0319 0.2422 0.2421
Trypanosoma cruzi Protein kinase B 0.0033 0.013 0.013
Echinococcus granulosus intermediate filament protein 0.0032 0.0118 0.0118
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0018 0.0007 0.0006
Trypanosoma brucei DNA polymerase kappa, putative 0.0048 0.0251 0.025
Chlamydia trachomatis geranylgeranyl pyrophosphate synthase 0.0319 0.2422 0.5
Loa Loa (eye worm) hypothetical protein 0.0036 0.0157 0.0157
Loa Loa (eye worm) polyprenyl synthetase 0.1263 1 1
Brugia malayi Polyprenyl synthetase family protein 0.0319 0.2422 0.2422
Giardia lamblia Kinase, AGC PKA 0.0033 0.013 0.0068
Echinococcus granulosus dna polymerase kappa 0.0048 0.0251 0.025
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0033 0.013 0.013
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0018 0.0007 0.0006
Schistosoma mansoni geranylgeranyl pyrophosphate synthase 0.0319 0.2422 0.2421
Entamoeba histolytica protein kinase, putative 0.0056 0.0316 0.1306
Trypanosoma brucei DNA polymerase kappa, putative 0.0048 0.0251 0.025
Brugia malayi cAMP-dependent protein kinase catalytic subunit, putative 0.0047 0.0245 0.0245
Schistosoma mansoni serine/threonine protein kinase 0.0047 0.0245 0.0245
Trichomonas vaginalis CMGC family protein kinase 0.0056 0.0316 0.031
Trichomonas vaginalis geranylgeranyl pyrophosphate synthase, putative 0.1263 1 1
Trichomonas vaginalis AGC family protein kinase 0.0049 0.0258 0.0252
Brugia malayi Protein kinase domain containing protein 0.0018 0.0007 0.0007
Echinococcus granulosus rho-associated protein kinase 1 0.0169 0.1216 0.1216
Echinococcus multilocularis enhancer of mRNA decapping protein 4 0.0046 0.0231 0.023
Brugia malayi Protein kinase domain containing protein 0.0521 0.4042 0.4042
Trypanosoma brucei DNA polymerase kappa, putative 0.0048 0.0251 0.025
Schistosoma mansoni serine/threonine protein kinase 0.0047 0.0245 0.0245
Loa Loa (eye worm) intermediate filament protein 0.0032 0.0118 0.0118
Trypanosoma brucei DNA polymerase kappa, putative 0.0025 0.0062 0.0062
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0018 0.0007 0.0007
Schistosoma mansoni intermediate filament proteins 0.0032 0.0118 0.0118
Entamoeba histolytica protein kinase domain containing protein 0.0056 0.0316 0.1306
Schistosoma mansoni glutathione synthetase 0.0319 0.2422 0.2421
Trichomonas vaginalis AGC family protein kinase 0.0049 0.0258 0.0252
Brugia malayi polk-prov protein 0.0036 0.0157 0.0157
Echinococcus granulosus farnesyl pyrophosphate synthase 0.1263 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.002 0.002
Echinococcus granulosus protein kinase c iota type 0.0018 0.0007 0.0006
Plasmodium falciparum cAMP-dependent protein kinase catalytic subunit 0.0047 0.0245 0.0116
Trypanosoma cruzi DNA polymerase kappa, putative 0.0048 0.0251 0.025
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0047 0.0245 0.0245
Echinococcus granulosus lamin 0.0032 0.0118 0.0118
Brugia malayi protein kinase C II. 0.0018 0.0007 0.0007
Trypanosoma brucei protein kinase A catalytic subunit, putative 0.0047 0.0245 0.0245
Echinococcus granulosus lamin dm0 0.0032 0.0118 0.0118
Trypanosoma cruzi polyprenyl synthase, putative 0.0319 0.2422 0.2421
Entamoeba histolytica PH domain containing protein kinase, putative 0.0033 0.013 0.0535
Trypanosoma brucei DNA polymerase kappa, putative 0.0036 0.0157 0.0156
Plasmodium falciparum geranylgeranyl pyrophosphate synthase, putative 0.1263 1 1
Entamoeba histolytica protein kinase domain containing protein 0.0056 0.0316 0.1306
Giardia lamblia Kinase, AGC PKA 0.0047 0.0245 0.0184
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0056 0.0316 0.0316
Mycobacterium tuberculosis Probable multifunctional geranylgeranyl pyrophosphate synthetase IdsA1 (GGPP synthetase) (ggppsase) (geranylgeranyl diphosphate 0.0319 0.2422 0.2421
Plasmodium vivax glycogen synthase kinase 3, putative 0.0056 0.0316 0.0189
Loa Loa (eye worm) AGC/PKA protein kinase 0.0047 0.0245 0.0245
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0033 0.013 0.013
Wolbachia endosymbiont of Brugia malayi geranylgeranyl pyrophosphate synthase 0.0319 0.2422 0.5
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 2 0.0047 0.0245 0.0245
Trichomonas vaginalis CMGC family protein kinase 0.0056 0.0316 0.031
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0056 0.0316 0.0316
Trypanosoma brucei DNA polymerase kappa, putative 0.0048 0.0251 0.025
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0047 0.0245 0.0245
Trypanosoma brucei protein kinase, putative 0.0056 0.0316 0.0316
Trypanosoma cruzi solanesyl-diphosphate synthase 0.0319 0.2422 0.2421
Entamoeba histolytica protein kinase, putative 0.0049 0.0258 0.1066
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0047 0.0245 0.0245
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0056 0.0316 0.0073
Loa Loa (eye worm) hypothetical protein 0.0018 0.0007 0.0007
Loa Loa (eye worm) AGC/NDR protein kinase 0.0018 0.0007 0.0007
Entamoeba histolytica PH domain containing protein kinase, putative 0.0047 0.0245 0.101
Loa Loa (eye worm) hypothetical protein 0.0047 0.0245 0.0245
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0047 0.0245 0.0245
Trypanosoma brucei DNA polymerase IV, putative 0.0048 0.0251 0.025
Leishmania major polyprenyl synthase, putative 0.0319 0.2422 0.2421
Schistosoma mansoni lamin 0.0032 0.0118 0.0118
Brugia malayi Protein kinase domain containing protein 0.0049 0.0258 0.0258
Echinococcus multilocularis decaprenyl diphosphate synthase subunit 1 0.0319 0.2422 0.2421
Trypanosoma cruzi solanesyl-diphosphate synthase, putative 0.0319 0.2422 0.2421
Entamoeba histolytica protein kinase, putative 0.0049 0.0258 0.1066
Echinococcus granulosus serine/threonine protein kinase 0.0033 0.013 0.013
Echinococcus granulosus nervana 2 0.0031 0.0116 0.0115
Echinococcus multilocularis lamin 0.0032 0.0118 0.0118
Echinococcus granulosus serine threonine protein kinase nrc 0.0033 0.013 0.013
Schistosoma mansoni serine/threonine kinase 0.0018 0.0007 0.0006
Mycobacterium tuberculosis Probable geranylgeranyl pyrophosphate synthetase IdsA2 (ggppsase) (GGPP synthetase) (geranylgeranyl diphosphate synthase) 0.1263 1 1
Trichomonas vaginalis AGC family protein kinase 0.0049 0.0258 0.0252
Mycobacterium ulcerans geranylgeranyl pyrophosphate synthase 0.1263 1 1
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0056 0.0316 0.0316
Loa Loa (eye worm) hypothetical protein 0.0032 0.0118 0.0118
Leishmania major farnesyl pyrophosphate synthase 0.1263 1 1
Schistosoma mansoni serine/threonine protein kinase 0.0018 0.0007 0.0006
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0018 0.0007 0.0006
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 1 0.0047 0.0245 0.0245
Trypanosoma brucei DNA polymerase kappa, putative 0.0036 0.0157 0.0156
Brugia malayi geranylgeranyl pyrophosphate synthetase 0.0319 0.2422 0.2422
Loa Loa (eye worm) AGC/DMPK/ROCK protein kinase 0.0521 0.4042 0.4042
Loa Loa (eye worm) geranylgeranyl pyrophosphate synthetase 0.0319 0.2422 0.2422
Trypanosoma brucei DNA polymerase kappa, putative 0.0048 0.0251 0.025
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 1 0.0047 0.0245 0.0245
Loa Loa (eye worm) hypothetical protein 0.0031 0.0113 0.0113
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 2 0.0047 0.0245 0.0245
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0047 0.0245 0.0245
Trichomonas vaginalis DNA polymerase eta, putative 0.0048 0.0251 0.0244
Mycobacterium ulcerans polyprenyl synthetase IdsB 0.0319 0.2422 0.2227
Mycobacterium ulcerans geranylgeranyl pyrophosphate synthase 0.1263 1 1
Echinococcus multilocularis serine:threonine protein kinase N2 0.0018 0.0007 0.0006
Echinococcus granulosus Protein kinase C brain isozyme 0.0018 0.0007 0.0006
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0056 0.0316 0.0316
Schistosoma mansoni serine/threonine-protein kinase 0.0033 0.013 0.013
Trypanosoma brucei DNA polymerase kappa, putative 0.0048 0.0251 0.025
Leishmania major DNA polymerase kappa, putative 0.0025 0.0062 0.0062
Giardia lamblia Kinase, CMGC GSK 0.0056 0.0316 0.0256
Onchocerca volvulus 0.0056 0.0316 0.1808
Echinococcus granulosus protein kinase shaggy 0.0056 0.0316 0.0316
Plasmodium falciparum glycogen synthase kinase 3 0.0056 0.0316 0.0189
Schistosoma mansoni serine/threonine protein kinase 0.0047 0.0245 0.0245
Entamoeba histolytica geranylgeranyl pyrophosphate synthase, putative 0.0319 0.2422 1
Echinococcus granulosus decaprenyl diphosphate synthase subunit 1 0.0319 0.2422 0.2421
Schistosoma mansoni serine/threonine protein kinase 0.0169 0.1216 0.1216
Entamoeba histolytica geranylgeranyl pyrophosphate synthetase, putative 0.0319 0.2422 1
Trichomonas vaginalis geranylgeranyl diphosphate synthase, putative 0.1263 1 1
Giardia lamblia Farnesyl diphosphate synthase 0.1263 1 1
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0018 0.0007 0.0007
Schistosoma mansoni lamin 0.0032 0.0118 0.0118
Leishmania major solanesyl-diphosphate synthase, putative 0.0319 0.2422 0.2421
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0025 0.0062 0.0062
Echinococcus multilocularis serine:threonine protein kinase N2 0.0018 0.0007 0.0006
Wolbachia endosymbiont of Brugia malayi geranylgeranyl pyrophosphate synthase 0.0319 0.2422 0.5
Echinococcus multilocularis nervana 2 0.0031 0.0116 0.0115
Leishmania major protein kinase A catalytic subunit isoform 2 0.0047 0.0245 0.0245
Trichomonas vaginalis AGC family protein kinase 0.0049 0.0258 0.0252
Schistosoma mansoni hypothetical protein 0.0199 0.146 0.146
Treponema pallidum octaprenyl-diphosphate synthase 0.0319 0.2422 0.5
Echinococcus multilocularis Glutaredoxin protein 5 0.0031 0.0116 0.0115
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0033 0.013 0.013
Entamoeba histolytica bifunctional short chain isoprenyl diphosphate synthase, putative 0.0319 0.2422 1
Echinococcus multilocularis serine threonine protein kinase 0.0018 0.0007 0.0006
Trichomonas vaginalis AGC family protein kinase 0.0049 0.0258 0.0252
Entamoeba histolytica protein kinase, putative 0.0049 0.0258 0.1066
Brugia malayi intracellular kinase 0.0056 0.0316 0.0316
Trypanosoma brucei DNA polymerase kappa, putative 0.0048 0.0251 0.025
Echinococcus multilocularis geranylgeranyl pyrophosphate synthase 0.0319 0.2422 0.2421
Mycobacterium leprae PROBABLE POLYPRENYL-DIPHOSPHATE SYNTHASE GRCC1 (POLYPRENYL PYROPHOSPHATE SYNTHETASE) 0.0319 0.2422 0.5
Onchocerca volvulus 0.0167 0.1202 0.9871
Schistosoma mansoni serine/threonine protein kinase 0.0018 0.0007 0.0006
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.002 0.002
Brugia malayi Hr1 repeat family protein 0.0018 0.0007 0.0007
Toxoplasma gondii polyprenyl synthetase superfamily protein 0.1263 1 1
Echinococcus granulosus nervana 2 0.0031 0.0116 0.0115
Echinococcus multilocularis geminin 0.0199 0.146 0.146
Echinococcus multilocularis nervana 2 0.0031 0.0116 0.0115
Loa Loa (eye worm) AGC/PKA protein kinase 0.0047 0.0245 0.0245
Schistosoma mansoni farnesyl pyrophosphate synthase 0.1263 1 1
Trypanosoma brucei solanesyl-diphosphate synthase, putative 0.0319 0.2422 0.2421
Trypanosoma brucei unspecified product 0.004 0.0189 0.0188
Echinococcus multilocularis lamin dm0 0.0032 0.0118 0.0118
Echinococcus granulosus serine:threonine protein kinase N2 0.0018 0.0007 0.0006
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0031 0.0116 0.0115
Leishmania major protein kinase A catalytic subunit 0.0047 0.0245 0.0245
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0049 0.0258 0.0258
Leishmania major protein kinase A catalytic subunit isoform 1 0.0047 0.0245 0.0245
Plasmodium vivax cAMP-dependent protein kinase catalytic subunit, putative 0.0047 0.0245 0.0116
Mycobacterium tuberculosis Probable polyprenyl-diphosphate synthase GrcC2 (polyprenyl pyrophosphate synthetase) 0.0319 0.2422 0.2421
Schistosoma mansoni atypical protein kinase C 0.0018 0.0007 0.0006
Brugia malayi p70 ribosomal S6 kinase beta 0.0049 0.0258 0.0258
Plasmodium vivax octaprenyl pyrophosphate synthase, putative 0.0319 0.2422 0.2322
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0056 0.0316 0.0316
Echinococcus multilocularis protein kinase c epsilon type 0.0018 0.0007 0.0006
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0033 0.013 0.013
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0047 0.0245 0.0245
Entamoeba histolytica PH domain containing protein kinase, putative 0.0047 0.0245 0.101
Loa Loa (eye worm) polyprenyl synthetase 0.0319 0.2422 0.2422
Mycobacterium tuberculosis Possible polyprenyl synthetase IdsB (polyprenyl transferase) (polyprenyl diphosphate synthase) 0.0319 0.2422 0.2421
Plasmodium falciparum octaprenyl pyrophosphate synthase 0.0319 0.2422 0.2322
Echinococcus multilocularis rac serine:threonine kinase 0.0033 0.013 0.013
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0047 0.0245 0.0245
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0047 0.0245 0.0245
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0048 0.0251 0.0244
Echinococcus granulosus prenyl decaprenyl diphosphate synthase 0.0319 0.2422 0.2421
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0031 0.0116 0.0115
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0047 0.0245 0.0245
Echinococcus multilocularis protein kinase c iota type 0.0018 0.0007 0.0006
Giardia lamblia Kinase, CMGC GSK 0.0056 0.0316 0.0256
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0025 0.0062 0.0062
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0018 0.0007 0.0007
Brugia malayi Intermediate filament tail domain containing protein 0.0032 0.0118 0.0118
Trypanosoma brucei farnesyl pyrophosphate synthase 0.1263 1 1
Schistosoma mansoni serine/threonine-protein kinase 0.0033 0.013 0.013
Trypanosoma cruzi farnesyl pyrophosphate synthase, putative 0.1263 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0048 0.0251 0.025
Schistosoma mansoni serine/threonine protein kinase 0.0018 0.0007 0.0006
Echinococcus multilocularis prenyl (decaprenyl) diphosphate synthase 0.0319 0.2422 0.2421
Echinococcus granulosus protein kinase c epsilon type 0.0018 0.0007 0.0006
Echinococcus multilocularis rho associated protein kinase 0.0169 0.1216 0.1216
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0018 0.0007 0.0006
Onchocerca volvulus 0.0169 0.1216 1
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0056 0.0316 0.0316
Brugia malayi intermediate filament protein 0.0032 0.0118 0.0118
Loa Loa (eye worm) AGC/AKT protein kinase 0.0049 0.0258 0.0258
Entamoeba histolytica protein kinase 2, putative 0.0033 0.013 0.0535
Entamoeba histolytica protein kinase, putative 0.0018 0.0007 0.0026
Echinococcus multilocularis farnesyl pyrophosphate synthase 0.1263 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0048 0.0251 0.025
Trypanosoma cruzi farnesyl pyrophosphate synthase 0.1263 1 1
Echinococcus granulosus enhancer of mRNA decapping protein 4 0.0046 0.0231 0.023
Trichomonas vaginalis AGC family protein kinase 0.0049 0.0258 0.0252
Toxoplasma gondii AGC kinase 0.0049 0.0258 0.0014
Trypanosoma cruzi DNA polymerase kappa, putative 0.0048 0.0251 0.025
Echinococcus multilocularis serine:threonine protein kinase 38 0.0018 0.0007 0.0006
Schistosoma mansoni serine/threonine protein kinase 0.0018 0.0007 0.0006
Trichomonas vaginalis geranylgeranyl pyrophosphate synthase, putative 0.1263 1 1
Trypanosoma brucei DNA polymerase IV, putative 0.0048 0.0251 0.025
Brugia malayi Protein kinase domain containing protein 0.0018 0.0007 0.0007
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0056 0.0316 0.0316
Echinococcus granulosus geminin 0.0199 0.146 0.146
Trichomonas vaginalis AGC family protein kinase 0.0047 0.0245 0.0238
Trypanosoma cruzi DNA polymerase kappa, putative 0.0048 0.0251 0.025
Schistosoma mansoni serine/threonine protein kinase 0.0018 0.0007 0.0006
Echinococcus granulosus Glutaredoxin protein 5 0.0031 0.0116 0.0115
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.002 0.002
Trypanosoma cruzi DNA polymerase kappa, putative 0.0048 0.0251 0.025
Schistosoma mansoni serine/threonine protein kinase 0.0018 0.0007 0.0006
Trypanosoma cruzi polyprenyl synthase, putative 0.0319 0.2422 0.2421
Echinococcus granulosus protein kinase C gamma type 0.0018 0.0007 0.0006
Echinococcus granulosus NDR protein kinase 0.0018 0.0007 0.0006
Entamoeba histolytica PH domain containing protein kinase, putative 0.0033 0.013 0.0535
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0018 0.0007 0.0006
Schistosoma mansoni hypothetical protein 0.0199 0.146 0.146
Schistosoma mansoni serine/threonine protein kinase 0.0018 0.0007 0.0006
Echinococcus multilocularis musashi 0.0032 0.0118 0.0118

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 2.9 uM Antagonist activity at CCR3 (unknown origin) expressed in B300-19 cells assessed as inhibition of eotaxin-induced calcium influx ChEMBL. 17951061
IC50 (functional) = 2.9 uM Antagonist activity at CCR3 (unknown origin) expressed in B300-19 cells assessed as inhibition of eotaxin-induced calcium influx ChEMBL. 17951061

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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