TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 367.504 | Formula: C22H25NO2S
H donors: 0 H acceptors: 0 LogP: 4.99 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccc(cc1)C(c1ccccc1OCCN(C)C)c1cccs1
InChi: 1S/C22H25NO2S/c1-23(2)14-15-25-20-8-5-4-7-19(20)22(21-9-6-16-26-21)17-10-12-18(24-3)13-11-17/h4-13,16,22H,14-15H2,1-3H3
InChiKey: KSOCFRYGXLPPFL-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0102	0.0438	1
Schistosoma mansoni	hypothetical protein	0.0034	0.0086	0.0062
Mycobacterium ulcerans	sugar-transport integral membrane protein SugI	0.0064	0.0241	0.5511
Toxoplasma gondii	protein kinase, putative	0.1289	0.6626	1
Entamoeba histolytica	hypothetical protein	0.0074	0.0294	0.4342
Entamoeba histolytica	hypothetical protein	0.0074	0.0294	0.4342
Trypanosoma brucei	hypothetical protein, conserved	0.0037	0.0098	0.1027
Echinococcus multilocularis	Sugar transporter ERD6 protein	0.0064	0.0241	0.0275
Leishmania major	threonyl-tRNA synthetase, putative	0.0026	0.0041	0.0218
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0241	0.1055
Echinococcus granulosus	GPCR family 2	0.0034	0.0086	0.0062
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0098	0.043
Schistosoma mansoni	hypothetical protein	0.0034	0.0086	0.0062
Trichomonas vaginalis	sugar transporter, putative	0.0064	0.0241	0.0956
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0241	0.1055
Onchocerca volvulus		0.0037	0.0098	0.0615
Echinococcus multilocularis	synaptic vesicle 2 protein	0.0064	0.0241	0.0275
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0037	0.0098	0.0869
Toxoplasma gondii	facilitative glucose transporter GT1	0.0456	0.2285	0.3424
Mycobacterium leprae	Probable lipase LipE	0.0037	0.0098	0.123
Loa Loa (eye worm)	CAMK/CAMK2 protein kinase	0.014	0.0635	0.2779
Plasmodium falciparum	calcium-dependent protein kinase 2	0.014	0.0635	0.0635
Trichomonas vaginalis	conserved hypothetical protein	0.0064	0.0241	0.0956
Loa Loa (eye worm)	threonyl-tRNA synthetase	0.0026	0.0041	0.0177
Trypanosoma brucei	glucose transporter, putative	0.0142	0.0644	0.868
Brugia malayi	hypothetical protein	0.0064	0.0241	0.093
Brugia malayi	Pre-SET motif family protein	0.0029	0.0059	0.0122
Schistosoma mansoni	hypothetical protein	0.0074	0.0294	0.0347
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.014	0.0635	0.0814
Brugia malayi	beta-lactamase family protein	0.0037	0.0098	0.0296
Treponema pallidum	prolyl-tRNA synthetase	0.0048	0.0159	1
Trichomonas vaginalis	sugar transporter, putative	0.0142	0.0644	0.274
Schistosoma mansoni	glucose transport protein	0.0456	0.2285	0.3074
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0241	0.1055
Mycobacterium ulcerans	threonyl-tRNA synthetase	0.0026	0.0041	0.0926
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0241	0.1055
Brugia malayi	threonyl-tRNA synthetase, cytoplasmic	0.0026	0.0041	0.004
Echinococcus granulosus	General substrate transporter	0.0392	0.195	0.2616
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0241	0.1055
Plasmodium vivax	CDK-related protein kinase 6, putative	0.1937	1	1
Onchocerca volvulus		0.0064	0.0241	0.1934
Schistosoma mansoni	glucose transporter	0.0064	0.0241	0.0275
Leishmania major	myo-inositol/proton symporter (MIT)	0.0064	0.0241	0.303
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0456	0.2285	0.3074
Loa Loa (eye worm)	sugar transporter	0.0064	0.0241	0.1055
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0.0032	0.0721
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.014	0.0635	0.0814
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0109	0.0472	0.1956
Trypanosoma brucei	glycyl-tRNA synthetase, putative	0.0026	0.0041	0.0218
Trypanosoma cruzi	sugar transporter, putative	0.0064	0.0241	0.303
Trypanosoma brucei	myo-inositol/proton symporter (MIT)	0.0064	0.0241	0.303
Echinococcus multilocularis	GPCR, family 2	0.0034	0.0086	0.0062
Trichomonas vaginalis	sugar transporter, putative	0.0064	0.0241	0.0956
Echinococcus granulosus	solute carrier family 22	0.0064	0.0241	0.0275
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0241	0.1055
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0029	0.0059	0.0025
Trichomonas vaginalis	D-aminoacylase, putative	0.0037	0.0098	0.0324
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0456	0.2285	0.3074
Plasmodium vivax	lysine--tRNA ligase, putative	0.0102	0.0438	0.0438
Plasmodium vivax	threonine--tRNA ligase, putative	0.0026	0.0041	0.0041
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0029	0.0059	0.0025
Trichomonas vaginalis	penicillin-binding protein, putative	0.0037	0.0098	0.0324
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0037	0.0098	0.0869
Trichomonas vaginalis	sugar transporter, putative	0.0064	0.0241	0.0956
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0098	0.043
Onchocerca volvulus		0.0064	0.0241	0.1934
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0137	0.062	0.0794
Trypanosoma brucei	glucose transporter, putative	0.0142	0.0644	0.868
Trichomonas vaginalis	sugar transporter, putative	0.0064	0.0241	0.0956
Echinococcus multilocularis	lysyl tRNA synthetase	0.0102	0.0438	0.0544
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0059	0.0258
Giardia lamblia	Sugar-proton symporter	0.0064	0.0241	0.346
Onchocerca volvulus		0.0064	0.0241	0.1934
Schistosoma mansoni	cellular tumor antigen P53	0.005	0.0167	0.0173
Onchocerca volvulus		0.0064	0.0241	0.1934
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.016	0.0738	1
Trypanosoma brucei	glucose transporter 1E	0.0142	0.0644	0.868
Leishmania major	4-coumarate:coa ligase-like protein	0.0024	0.0032	0.0092
Onchocerca volvulus		0.0064	0.0241	0.1934
Onchocerca volvulus		0.0064	0.0241	0.1934
Mycobacterium ulcerans	sugar transporter	0.0064	0.0241	0.5511
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0023	0.0025	0.0221
Loa Loa (eye worm)	hypothetical protein	0.0109	0.0472	0.2067
Trypanosoma brucei	glucose transporter, putative	0.0142	0.0644	0.868
Loa Loa (eye worm)	hypothetical protein	0.0137	0.062	0.2714
Schistosoma mansoni	serine/threonine protein kinase	0.014	0.0635	0.0814
Entamoeba histolytica	glycyl-tRNA synthetase, putative	0.0026	0.0041	0.0149
Loa Loa (eye worm)	hypothetical protein	0.005	0.0167	0.0731
Loa Loa (eye worm)	bifunctional aminoacyl-tRNA synthetase	0.0056	0.02	0.0874
Echinococcus multilocularis	solute carrier family 22	0.0064	0.0241	0.0275
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0024	0.0032	0.0721
Echinococcus multilocularis	glutamyl tRNA synthetase cytoplasmic	0.0137	0.062	0.0794
Loa Loa (eye worm)	hypothetical protein	0.014	0.0635	0.2779
Trichomonas vaginalis	CAMK family protein kinase	0.014	0.0635	0.2699
Plasmodium vivax	calcium-dependent protein kinase 4, putative	0.014	0.0635	0.0635
Trichomonas vaginalis	sugar transporter, putative	0.0064	0.0241	0.0956
Echinococcus multilocularis	General substrate transporter	0.0392	0.195	0.2616
Mycobacterium ulcerans	hypothetical protein	0.0023	0.0025	0.057
Mycobacterium leprae	Possible lysyl-tRNA synthetase 2 LysX	0.0102	0.0438	0.6932
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0032	0.0138
Mycobacterium tuberculosis	Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter)	0.0064	0.0241	0.2134
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0456	0.2285	0.3074
Trichomonas vaginalis	sugar transporter, putative	0.0064	0.0241	0.0956
Onchocerca volvulus		0.0064	0.0241	0.1934
Plasmodium vivax	calcium-dependent protein kinase 3, putative	0.014	0.0635	0.0635
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0034	0.0086	0.0062
Onchocerca volvulus		0.0064	0.0241	0.1934
Onchocerca volvulus		0.0064	0.0241	0.1934
Toxoplasma gondii	calcium-dependent protein kinase CDPK2B	0.014	0.0635	0.0925
Giardia lamblia	Hexose transporter	0.0064	0.0241	0.346
Schistosoma mansoni	nuclear transcription factor X-box binding 1 (nfx1)	0.0064	0.0241	0.0275
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0037	0.0098	0.0079
Echinococcus multilocularis	microtubule associated protein 2	0.1427	0.7342	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0098	0.043
Entamoeba histolytica	protein kinase, putative	0.014	0.0635	1
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0204	0.0969	0.4239
Brugia malayi	hypothetical protein	0.0064	0.0241	0.093
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0102	0.0438	0.1826
Trichomonas vaginalis	sugar transporter, putative	0.0064	0.0241	0.0956
Chlamydia trachomatis	threonine--tRNA ligase	0.0026	0.0041	0.0926
Trichomonas vaginalis	myo-inositol transporter, putative	0.0064	0.0241	0.0956
Trichomonas vaginalis	sugar transporter, putative	0.0064	0.0241	0.0956
Trichomonas vaginalis	D-aminoacylase, putative	0.0037	0.0098	0.0324
Trypanosoma cruzi	hexose transporter	0.0142	0.0644	0.868
Onchocerca volvulus		0.0037	0.0098	0.0615
Trichomonas vaginalis	penicillin-binding protein, putative	0.0037	0.0098	0.0324
Onchocerca volvulus		0.0029	0.0059	0.0254
Toxoplasma gondii	lysine-tRNA ligase	0.0102	0.0438	0.0625
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0034	0.0086	0.024
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0241	0.1055
Echinococcus multilocularis	solute carrier family 2, facilitated glucose	0.0456	0.2285	0.3074
Echinococcus granulosus	histone lysine methyltransferase setb	0.0029	0.0059	0.0025
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0029	0.0059	0.0052
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0049	0.0161	0.0576
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0041	0.0177
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0241	0.1055
Schistosoma mansoni	lysyl-tRNA synthetase	0.0102	0.0438	0.0544
Schistosoma mansoni	hypothetical protein	0.0074	0.0293	0.0346
Chlamydia trachomatis	proline--tRNA ligase	0.0048	0.0159	0.3628
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0024	0.0032	0.0721
Toxoplasma gondii	threonyl-tRNA synthetase family protein	0.0026	0.0041	0.0024
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0241	0.1055
Echinococcus multilocularis	calcium dependent protein kinase	0.0131	0.059	0.0752
Schistosoma mansoni	transcription factor LCR-F1	0.0074	0.0294	0.0347
Entamoeba histolytica	hypothetical protein	0.0074	0.0294	0.4342
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0037	0.0098	0.0869
Loa Loa (eye worm)	sugar transporter	0.0456	0.2285	1
Plasmodium vivax	hexose transporter	0.0456	0.2285	0.2285
Trichomonas vaginalis	glucose transporter, putative	0.0064	0.0241	0.0956
Echinococcus granulosus	tumor protein p63	0.0341	0.1686	0.2253
Trichomonas vaginalis	conserved hypothetical protein	0.0142	0.0644	0.274
Schistosoma mansoni	hypothetical protein	0.0049	0.0161	0.0166
Plasmodium falciparum	protein kinase 7	0.1289	0.6626	0.6626
Trypanosoma brucei	calcium/calmodulin-dependent protein kinase, putative	0.014	0.0635	0.855
Trichomonas vaginalis	sugar transporter, putative	0.0064	0.0241	0.0956
Trichomonas vaginalis	conserved hypothetical protein	0.0064	0.0241	0.0956
Trichomonas vaginalis	conserved hypothetical protein	0.0142	0.0644	0.274
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0235	0.113	1
Plasmodium falciparum	major facilitator superfamily domain-containing protein, putative	0.0064	0.0241	0.0241
Onchocerca volvulus		0.0232	0.1115	1
Chlamydia trachomatis	lysine--tRNA ligase	0.0102	0.0438	1
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0.0032	0.0721
Schistosoma mansoni	hypothetical protein	0.0034	0.0086	0.0062
Mycobacterium leprae	Probable prolyl tRNA synthetase ProS	0.0137	0.062	1
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0109	0.0472	0.1956
Mycobacterium tuberculosis	Probable lipase LipD	0.0037	0.0098	0.0869
Plasmodium falciparum	calcium-dependent protein kinase 1	0.014	0.0635	0.0635
Brugia malayi	Latrophilin receptor protein 2	0.0034	0.0086	0.024
Mycobacterium tuberculosis	Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase)(ThrRS) (threonine-tRNA ligase)	0.0026	0.0041	0.0359
Schistosoma mansoni	sugar transporter	0.0064	0.0241	0.0275
Trichomonas vaginalis	sugar transporter, putative	0.0064	0.0241	0.0956
Brugia malayi	hypothetical protein	0.024	0.1155	0.4988
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0029	0.0059	0.0025
Onchocerca volvulus		0.0064	0.0241	0.1934
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0064	0.0241	0.1055
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0074	0.0294	0.0347
Trichomonas vaginalis	esterase, putative	0.0037	0.0098	0.0324
Echinococcus granulosus	microtubule associated protein 2	0.1427	0.7342	1
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0241	0.1055
Plasmodium vivax	calcium-dependent protein kinase, putative	0.014	0.0635	0.0635
Brugia malayi	Pre-SET motif family protein	0.0204	0.0969	0.4159
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0142	0.0644	0.868
Trypanosoma cruzi	lysyl-tRNA synthetase, putative	0.0102	0.0438	0.5783
Toxoplasma gondii	sugar transporter ST2	0.0064	0.0241	0.0327
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0028	0.0053	0.0018
Trypanosoma cruzi	hexose transporter, putative	0.0142	0.0644	0.868
Onchocerca volvulus		0.0064	0.0241	0.1934
Brugia malayi	Major Facilitator Superfamily protein	0.0064	0.0241	0.093
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0037	0.0098	0.0079
Trichomonas vaginalis	sugar transporter, putative	0.0064	0.0241	0.0956
Trichomonas vaginalis	sugar transporter, putative	0.0064	0.0241	0.0956
Schistosoma mansoni	protein kinase	0.014	0.0635	0.0814
Trichomonas vaginalis	conserved hypothetical protein	0.0456	0.2285	1
Trichomonas vaginalis	sugar transporter, putative	0.0064	0.0241	0.0956
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0034	0.0086	0.0375
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0089	0.0372	0.1536
Trichomonas vaginalis	D-aminoacylase, putative	0.0037	0.0098	0.0324
Trichomonas vaginalis	conserved hypothetical protein	0.0064	0.0241	0.0956
Trichomonas vaginalis	sugar transporter, putative	0.0064	0.0241	0.0956
Trypanosoma brucei	glucose transporter, putative	0.0142	0.0644	0.868
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0024	0.0032	0.0279
Trichomonas vaginalis	sugar transporter, putative	0.0064	0.0241	0.0956
Echinococcus granulosus	solute carrier family 22	0.0064	0.0241	0.0275
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0241	0.1055
Mycobacterium ulcerans	prolyl-tRNA synthetase	0.0048	0.0159	0.3628
Leishmania major	lysyl-tRNA synthetase, putative	0.0102	0.0438	0.5783
Echinococcus granulosus	synaptic vesicle 2 protein	0.0064	0.0241	0.0275
Trichomonas vaginalis	sugar transporter, putative	0.0064	0.0241	0.0956
Trichomonas vaginalis	sugar transporter, putative	0.0064	0.0241	0.0956
Brugia malayi	major facilitator superfamily protein	0.0064	0.0241	0.093
Leishmania major	hypothetical protein, conserved	0.0064	0.0241	0.303
Trypanosoma brucei	glucose transporter 2A	0.0142	0.0644	0.868
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0241	0.1055
Trypanosoma cruzi	glucose transporter, putative	0.0064	0.0241	0.303
Onchocerca volvulus		0.0064	0.0241	0.1934
Mycobacterium leprae	conserved hypothetical protein	0.0037	0.0098	0.123
Brugia malayi	hypothetical protein	0.0074	0.0294	0.1163
Schistosoma mansoni	protein kinase	0.014	0.0635	0.0814
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0241	0.1055
Loa Loa (eye worm)	hypothetical protein	0.0102	0.0438	0.1915
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 2 LysX	0.0087	0.0358	0.3164
Toxoplasma gondii	prolyl-tRNA synthetase (ProRS)	0.016	0.0738	0.1081
Schistosoma mansoni	glucose transport protein	0.0456	0.2285	0.3074
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0086	0.0375
Trypanosoma brucei	glucose transporter, putative	0.0142	0.0644	0.868
Onchocerca volvulus		0.0064	0.0241	0.1934
Trypanosoma brucei	glucose transporter, putative	0.0142	0.0644	0.868
Trichomonas vaginalis	prolyl-tRNA synthetase, putative	0.0137	0.062	0.2634
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0037	0.0098	0.0296
Trypanosoma cruzi	hexose transporter, putative	0.0064	0.0241	0.303
Mycobacterium tuberculosis	Conserved protein	0.0037	0.0098	0.0869
Trichomonas vaginalis	sugar transporter, putative	0.0064	0.0241	0.0956
Onchocerca volvulus		0.0064	0.0241	0.1934
Plasmodium falciparum	proline--tRNA ligase	0.016	0.0738	0.0738
Loa Loa (eye worm)	hypothetical protein	0.0137	0.062	0.2714
Trichomonas vaginalis	conserved hypothetical protein	0.0064	0.0241	0.0956
Brugia malayi	Sugar transporter family protein	0.0064	0.0241	0.093
Entamoeba histolytica	threonyl-tRNA synthetase, putative	0.0026	0.0041	0.0149
Brugia malayi	Bifunctional aminoacyl-tRNA synthetase	0.0137	0.062	0.2612
Trypanosoma cruzi	hexose transporter, putative	0.0142	0.0644	0.868
Trichomonas vaginalis	sugar transporter, putative	0.0064	0.0241	0.0956
Trypanosoma brucei	glucose transporter, putative	0.0142	0.0644	0.868
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0029	0.0059	0.0025
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0037	0.0098	0.2244
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0109	0.0472	0.2067
Mycobacterium tuberculosis	Probable conserved integral membrane transport protein	0.0064	0.0241	0.2134
Loa Loa (eye worm)	hypothetical protein	0.0111	0.0486	0.2129
Mycobacterium tuberculosis	Probable hydrolase	0.0037	0.0098	0.0869
Trichomonas vaginalis	sugar transporter, putative	0.0064	0.0241	0.0956
Schistosoma mansoni	sugar transporter	0.0064	0.0241	0.0275
Echinococcus granulosus	survival motor neuron protein 1	0.024	0.1155	0.1527
Trichomonas vaginalis	sugar transporter, putative	0.0064	0.0241	0.0956
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0024	0.0032	0.0279
Leishmania major	glucose transporter, lmgt3	0.0142	0.0644	0.868
Brugia malayi	hypothetical protein	0.0064	0.0241	0.093
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.0087	0.0358	0.3164
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0037	0.0098	0.0079
Onchocerca volvulus		0.0037	0.0098	0.0615
Toxoplasma gondii	sugar transporter ST1	0.0064	0.0241	0.0327
Plasmodium vivax	proline--tRNA ligase, putative	0.016	0.0738	0.0738
Onchocerca volvulus	Putative transporter	0.0064	0.0241	0.1934
Trichomonas vaginalis	sugar transporter, putative	0.0064	0.0241	0.0956
Trichomonas vaginalis	threonyl-tRNA synthetase, putative	0.0026	0.0041	0.0069
Trichomonas vaginalis	sugar transporter, putative	0.0064	0.0241	0.0956
Toxoplasma gondii	calcium-dependent protein kinase CDPK2A	0.014	0.0635	0.0925
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0.0032	0.0721
Brugia malayi	Major Facilitator Superfamily protein	0.0064	0.0241	0.093
Schistosoma mansoni	survival motor neuron protein	0.0049	0.0161	0.0166
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.014	0.0635	0.0814
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0024	0.0032	0.0111
Trichomonas vaginalis	sugar transporter, putative	0.0064	0.0241	0.0956
Onchocerca volvulus		0.0064	0.0241	0.1934
Mycobacterium ulcerans	fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT	0.0064	0.0241	0.5511
Giardia lamblia	Lysyl-tRNA synthetase	0.0102	0.0438	0.6849
Mycobacterium leprae	Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.0087	0.0358	0.5587
Brugia malayi	latrophilin 2 splice variant baaae	0.0074	0.0293	0.1162
Trichomonas vaginalis	sugar transporter, putative	0.0064	0.0241	0.0956
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0456	0.2285	0.3074
Plasmodium vivax	calcium-dependent protein kinase 1, putative	0.014	0.0635	0.0635
Toxoplasma gondii	calcium-dependent protein kinase CDPK3	0.014	0.0635	0.0925
Onchocerca volvulus		0.0049	0.0161	0.1198
Brugia malayi	glycyl-tRNA synthetase	0.0026	0.0041	0.004
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0102	0.0438	1
Giardia lamblia	Prolyl-tRNA synthetase	0.0137	0.062	1
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0032	0.0138
Loa Loa (eye worm)	calcium/calmodulin-dependent protein kinase ID	0.014	0.0635	0.2779
Echinococcus multilocularis	solute carrier family 22	0.0064	0.0241	0.0275
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0024	0.0032	0.0111
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type 1	0.014	0.0635	0.0814
Trichomonas vaginalis	sugar transporter, putative	0.0064	0.0241	0.0956
Trypanosoma cruzi	threonyl-tRNA synthetase, putative	0.0026	0.0041	0.0218
Brugia malayi	probable proline-trna synthetase - fission yeast, putative	0.0026	0.0041	0.004
Trypanosoma cruzi	hypothetical protein, conserved	0.0037	0.0098	0.1027
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0029	0.0059	0.0025
Echinococcus granulosus	calcium dependent protein kinase	0.0131	0.059	0.0752
Plasmodium falciparum	lysine--tRNA ligase	0.0102	0.0438	0.0438
Schistosoma mansoni	lysyl-tRNA synthetase	0.0102	0.0438	0.0544
Brugia malayi	beta-lactamase family protein	0.0037	0.0098	0.0296
Mycobacterium ulcerans	lipase LipD	0.0037	0.0098	0.2244
Echinococcus granulosus	solute carrier family 22	0.0064	0.0241	0.0275
Trichomonas vaginalis	sugar transport protein, putative	0.0064	0.0241	0.0956
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.014	0.0635	0.0814
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0142	0.0644	0.868
Schistosoma mansoni	hypothetical protein	0.0456	0.2285	0.3074
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0142	0.0644	0.868
Leishmania major	4-coumarate:coa ligase-like protein	0.0024	0.0032	0.0092
Trypanosoma cruzi	hypothetical protein, conserved	0.0037	0.0098	0.1027
Trichomonas vaginalis	glucose transporter, putative	0.0142	0.0644	0.274
Trichomonas vaginalis	sugar transporter, putative	0.0064	0.0241	0.0956
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0024	0.0032	0.0721
Trypanosoma cruzi	hexose transporter, putative	0.0077	0.031	0.3994
Trypanosoma brucei	sugar transporter, putative	0.0064	0.0241	0.303
Trichomonas vaginalis	sugar transporter, putative	0.0064	0.0241	0.0956
Trichomonas vaginalis	sugar transporter, putative	0.0064	0.0241	0.0956
Entamoeba histolytica	hypothetical protein	0.0074	0.0294	0.4342
Echinococcus granulosus	glutamyl tRNA synthetase cytoplasmic	0.0137	0.062	0.0794
Brugia malayi	Sugar transporter family protein	0.0456	0.2285	1
Entamoeba histolytica	hypothetical protein	0.0102	0.0438	0.6729
Leishmania major	4-coumarate:coa ligase-like protein	0.0024	0.0032	0.0092
Mycobacterium leprae	Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase) (ThrRS) (Threonine-tRNA ligase)	0.0026	0.0041	0.0262
Trichomonas vaginalis	sugar transporter, putative	0.0064	0.0241	0.0956
Leishmania major	glucose transporter, lmgt2	0.0142	0.0644	0.868
Trichomonas vaginalis	sugar transporter, putative	0.0064	0.0241	0.0956
Brugia malayi	lysyl-tRNA synthetase	0.0102	0.0438	0.1802
Trypanosoma brucei	threonyl-tRNA synthetase, putative	0.0026	0.0041	0.0218
Trichomonas vaginalis	glucose transporter, putative	0.0142	0.0644	0.274
Brugia malayi	Cam kinase protein 1	0.014	0.0635	0.2678
Mycobacterium ulcerans	glycyl-tRNA synthetase	0.0026	0.0041	0.0926
Toxoplasma gondii	sugar transporter ST3	0.0064	0.0241	0.0327
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0074	0.0294	0.0347
Plasmodium vivax	glycine--tRNA ligase, putative	0.0026	0.0041	0.0041
Toxoplasma gondii	glycyl-tRNA synthetase	0.0026	0.0041	0.0024
Brugia malayi	Major Facilitator Superfamily protein	0.0064	0.0241	0.093
Toxoplasma gondii	ABC1 family protein	0.0037	0.0098	0.0111
Leishmania major	glucose transporter, lmgt1	0.0142	0.0644	0.868
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0456	0.2285	0.3074
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.014	0.0635	0.0814
Trichomonas vaginalis	sugar transporter, putative	0.0064	0.0241	0.0956
Leishmania major	hypothetical protein, conserved	0.0037	0.0098	0.1027
Plasmodium vivax	sugar transporter, putative	0.0064	0.0241	0.0241
Schistosoma mansoni	hypothetical protein	0.0034	0.0086	0.0062
Loa Loa (eye worm)	hypothetical protein	0.024	0.1155	0.5057
Echinococcus granulosus	lysyl tRNA synthetase	0.0102	0.0438	0.0544
Trichomonas vaginalis	sugar transporter, putative	0.0064	0.0241	0.0956
Mycobacterium ulcerans	integral membrane transport protein	0.0064	0.0241	0.5511
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0098	0.043
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0098	0.043
Toxoplasma gondii	transporter, major facilitator family protein	0.0064	0.0241	0.0327
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0456	0.2285	0.3074
Plasmodium falciparum	mitogen-activated protein kinase 2	0.0737	0.375	0.375
Trichomonas vaginalis	sugar transporter, putative	0.0142	0.0644	0.274
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0037	0.0098	0.043
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.016	0.0738	1
Wolbachia endosymbiont of Brugia malayi	major facilitator superfamily permease	0.0064	0.0241	1
Onchocerca volvulus		0.0064	0.0241	0.1934
Trichomonas vaginalis	set domain proteins, putative	0.0232	0.1115	0.4825
Mycobacterium ulcerans	hypothetical protein	0.0037	0.0098	0.2244
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0241	0.1055
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0241	0.1055
Mycobacterium tuberculosis	Probable lipase LipE	0.0037	0.0098	0.0869
Trypanosoma brucei	bifunctional aminoacyl-tRNA synthetase, putative	0.016	0.0738	1
Plasmodium vivax	mitogen-activated protein kinase 2, putative	0.0737	0.375	0.375
Schistosoma mansoni	microtubule-associated protein tau	0.1427	0.7342	1
Mycobacterium tuberculosis	Conserved protein	0.0037	0.0098	0.0869
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.016	0.0738	1
Trypanosoma brucei	glucose transporter, putative	0.0142	0.0644	0.868
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.014	0.0635	0.0814
Leishmania major	protein kinase, putative	0.014	0.0635	0.855
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0029	0.0059	0.0025
Plasmodium falciparum	calcium-dependent protein kinase 4	0.014	0.0635	0.0635
Brugia malayi	Calcium/calmodulin-dependent protein kinase type II alpha chain	0.014	0.0635	0.2678
Plasmodium falciparum	calcium-dependent protein kinase 5	0.014	0.0635	0.0635
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0137	0.062	0.0794
Echinococcus multilocularis	tumor protein p63	0.0341	0.1686	0.2253
Trypanosoma cruzi	hexose transporter, putative	0.0142	0.0644	0.868
Mycobacterium ulcerans	beta-lactamase	0.0037	0.0098	0.2244
Trichomonas vaginalis	sugar transporter, putative	0.0064	0.0241	0.0956
Plasmodium vivax	hypothetical protein, conserved	0.0037	0.0098	0.0098
Echinococcus multilocularis	survival motor neuron protein 1	0.024	0.1155	0.1527
Echinococcus granulosus	solute carrier family 22	0.0064	0.0241	0.0275
Trypanosoma brucei	lysyl-tRNA synthetase, putative	0.0102	0.0438	0.5783
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0034	0.0086	0.0062
Trichomonas vaginalis	conserved hypothetical protein	0.0064	0.0241	0.0956
Trichomonas vaginalis	sugar transporter, putative	0.0064	0.0241	0.0956
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0034	0.0086	0.0062
Schistosoma mansoni	glucose transport protein	0.0456	0.2285	0.3074
Leishmania major	glucose transporter/membrane transporter D2, putative	0.0142	0.0644	0.868
Brugia malayi	beta-lactamase	0.0037	0.0098	0.0296
Trypanosoma cruzi	threonyl-tRNA synthetase, putative	0.0026	0.0041	0.0218
Schistosoma mansoni	protein kinase	0.014	0.0635	0.0814
Loa Loa (eye worm)	glycyl-tRNA synthetase	0.0026	0.0041	0.0177
Loa Loa (eye worm)	beta-lactamase	0.0037	0.0098	0.043
Plasmodium falciparum	calcium-dependent protein kinase 3	0.014	0.0635	0.0635
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0032	0.0138
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0456	0.2285	0.3074
Mycobacterium tuberculosis	Probable esterase LipL	0.0037	0.0098	0.0869
Onchocerca volvulus		0.005	0.0167	0.1251
Plasmodium falciparum	hexose transporter	0.0456	0.2285	0.2285
Schistosoma mansoni	sugar transporter	0.0064	0.0241	0.0275
Mycobacterium ulcerans	esterase/lipase LipP	0.0037	0.0098	0.2244
Mycobacterium tuberculosis	Conserved protein	0.0037	0.0098	0.0869
Entamoeba histolytica	prolyl-tRNA synthetase, putative	0.0137	0.062	0.9756
Trichomonas vaginalis	sugar transporter, putative	0.0142	0.0644	0.274
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0293	0.1284
Entamoeba histolytica	protein kinase, putative	0.014	0.0635	1
Brugia malayi	bifunctional aminoacyl-tRNA synthetase	0.0137	0.062	0.2612
Echinococcus multilocularis	solute carrier family 22	0.0064	0.0241	0.0275
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0098	0.043
Plasmodium vivax	SET domain protein, putative	0.0029	0.0059	0.0059
Echinococcus granulosus	Sugar transporter ERD6 protein	0.0064	0.0241	0.0275
Plasmodium falciparum	threonine--tRNA ligase	0.0026	0.0041	0.0041
Brugia malayi	Sugar transporter family protein	0.0064	0.0241	0.093
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0024	0.0032	0.0721
Mycobacterium ulcerans	hypothetical protein	0.0024	0.0032	0.0721
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0064	0.0241	0.1055
Schistosoma mansoni	sugar transporter	0.0064	0.0241	0.0275
Echinococcus multilocularis	solute carrier family 22	0.0064	0.0241	0.0275
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.016	0.0738	1
Toxoplasma gondii	cell-cycle-associated protein kinase MAPK, putative	0.0737	0.375	0.5643
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.014	0.0635	0.0814
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0034	0.0086	0.0062
Echinococcus granulosus	beta LACTamase domain containing family member	0.0037	0.0098	0.0079
Brugia malayi	major facilitator superfamily protein	0.0064	0.0241	0.093

Activities

Activity type	Activity value	Assay description	Source	Reference
MIC (functional)	> 12.5 ug ml-1	Antitubercular activity against Mycobacterium tuberculosis H37Rv by agar dilution method	ChEMBL.	17997304
MIC (functional)	> 12.5 ug ml-1	Antitubercular activity against Mycobacterium tuberculosis H37Rv by agar dilution method	ChEMBL.	17997304

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 521668