Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Serotonin transporter | Starlite/ChEMBL | References |
Rattus norvegicus | Dopamine transporter | Starlite/ChEMBL | References |
Rattus norvegicus | Norepinephrine transporter | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0292 | 0.5738 | 0.4476 |
Loa Loa (eye worm) | hypothetical protein | 0.0292 | 0.5738 | 0.4476 |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.0292 | 0.5738 | 0.4476 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0251 | 0.4753 | 0.3299 |
Brugia malayi | Acyl-CoA oxidase family protein | 0.0445 | 0.9436 | 0.9269 |
Schistosoma mansoni | tyrosine kinase | 0.0468 | 1 | 1 |
Loa Loa (eye worm) | serotonin transporter b | 0.0292 | 0.5738 | 0.4476 |
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.0468 | 1 | 1 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0468 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0389 | 0.8096 | 0.7532 |
Schistosoma mansoni | tyrosine kinase | 0.0251 | 0.4753 | 0.32 |
Loa Loa (eye worm) | acyl-CoA oxidase | 0.0274 | 0.5306 | 0.3917 |
Echinococcus multilocularis | serotonin transporter | 0.0292 | 0.5738 | 0.4557 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0468 | 1 | 1 |
Mycobacterium ulcerans | acyl-CoA dehydrogenase | 0.0055 | 0 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0251 | 0.4753 | 0.32 |
Schistosoma mansoni | tyrosine kinase | 0.0249 | 0.4688 | 0.3117 |
Loa Loa (eye worm) | hypothetical protein | 0.0292 | 0.5738 | 0.4476 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0149 | 0.2283 | 0.0145 |
Toxoplasma gondii | acyl-CoA dehydrogenase, middle domain-containing protein | 0.0445 | 0.9436 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0249 | 0.4688 | 0.3117 |
Echinococcus multilocularis | insulin receptor | 0.0149 | 0.2283 | 0.0145 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0292 | 0.5738 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0292 | 0.5738 | 0.4476 |
Schistosoma mansoni | tyrosine kinase | 0.0249 | 0.4688 | 0.3117 |
Onchocerca volvulus | 0.0292 | 0.5738 | 0.5 | |
Echinococcus granulosus | epidermal growth factor receptor | 0.0251 | 0.4753 | 0.32 |
Echinococcus granulosus | serotonin transporter | 0.0292 | 0.5738 | 0.4476 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0292 | 0.5738 | 0.4476 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0292 | 0.5738 | 0.4476 |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.0251 | 0.4753 | 0.32 |
Loa Loa (eye worm) | norepinephrine transporter | 0.0292 | 0.5738 | 0.4476 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 45 nM | Inhibitory activity in displacing [125I]- RTI-55 binding to dopamine transporter in rat striatal membranes | ChEMBL. | 11334561 |
IC50 (binding) | = 45 nM | Inhibitory activity in displacing [125I]- RTI-55 binding to dopamine transporter in rat striatal membranes | ChEMBL. | 11334561 |
Ki (binding) | = 88 nM | Affinity for the displacement of [3H]-paroxetine binding to serotonin transporter (SERT) in rat frontal cortex membranes | ChEMBL. | 11334561 |
Ki (binding) | = 88 nM | Affinity for the displacement of [3H]-paroxetine binding to serotonin transporter (SERT) in rat frontal cortex membranes | ChEMBL. | 11334561 |
Ki (binding) | = 2334 nM | Affinity for the displacement of [3H]-paroxetine binding to norepinephrine transporter (NET) in rat frontal cortex membranes | ChEMBL. | 11334561 |
Ki (binding) | = 2334 nM | Affinity for the displacement of [3H]-paroxetine binding to norepinephrine transporter (NET) in rat frontal cortex membranes | ChEMBL. | 11334561 |
Potency ratio (binding) | = 0.5 | SERT/DAT (serotonin transporter/dopamine transporter) binding potency ratio | ChEMBL. | 11334561 |
Potency ratio (binding) | = 26.5 | SERT/NET binding potency ratio | ChEMBL. | 11334561 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.