Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | methylthioadenosine phosphorylase | 0.0633 | 1 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0097 | 0.0849 | 0.0849 |
Schistosoma mansoni | purine nucleoside phosphorylase | 0.0117 | 0.1201 | 0.1201 |
Trichomonas vaginalis | purine nucleoside phosphorylase, putative | 0.0117 | 0.1201 | 0.5 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0117 | 0.1201 | 0.1201 |
Giardia lamblia | UPL-1 | 0.0117 | 0.1201 | 0.5 |
Schistosoma mansoni | uridine phosphorylase | 0.0117 | 0.1201 | 0.1201 |
Brugia malayi | purine nucleoside phosphorylase I, inosine and guanosine-specific family protein | 0.0117 | 0.1201 | 0.1201 |
Brugia malayi | uridine phosphorylase family protein | 0.0117 | 0.1201 | 0.1201 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0117 | 0.1201 | 0.1201 |
Trichomonas vaginalis | purine nucleoside phosphorylase, putative | 0.0117 | 0.1201 | 0.5 |
Trichomonas vaginalis | purine nucleoside phosphorylase, putative | 0.0117 | 0.1201 | 0.5 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0117 | 0.1201 | 0.1201 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0122 | 0.1286 | 0.1286 |
Mycobacterium ulcerans | 5'-methylthioadenosine phosphorylase | 0.0633 | 1 | 1 |
Treponema pallidum | pfs protein (pfs) | 0.0117 | 0.1201 | 0.5 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0117 | 0.1201 | 0.1201 |
Schistosoma mansoni | methylthioadenosine phosphorylase | 0.0633 | 1 | 1 |
Giardia lamblia | 5-methylthioadenosine nucleosidase, S-adenosylhomocysteine nucleosidase | 0.0117 | 0.1201 | 0.5 |
Trypanosoma brucei | methylthioadenosine phosphorylase, putative | 0.0633 | 1 | 1 |
Schistosoma mansoni | methylthioadenosine phosphorylase | 0.0633 | 1 | 1 |
Schistosoma mansoni | purine nucleoside phosphorylase | 0.0117 | 0.1201 | 0.1201 |
Mycobacterium tuberculosis | Probable bifunctional MTA/SAH nucleosidase Mtn: 5'-methylthioadenosine nucleosidase (methylthioadenosine methylthioribohydrolase | 0.0117 | 0.1201 | 0.1259 |
Echinococcus multilocularis | geminin | 0.0173 | 0.216 | 0.216 |
Echinococcus granulosus | methylthioadenosine phosphorylase | 0.0633 | 1 | 1 |
Echinococcus multilocularis | uridine phosphorylase 1 | 0.0117 | 0.1201 | 0.1201 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.172 | 0.172 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0117 | 0.1201 | 0.5 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.006 | 0.0221 | 0.0221 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0117 | 0.1201 | 0.1201 |
Onchocerca volvulus | 0.0148 | 0.172 | 1 | |
Leishmania major | methylthioadenosine phosphorylase, putative | 0.0633 | 1 | 1 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.006 | 0.0221 | 0.0221 |
Brugia malayi | MH2 domain containing protein | 0.0122 | 0.1286 | 0.1286 |
Schistosoma mansoni | hypothetical protein | 0.0066 | 0.0327 | 0.0327 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0117 | 0.1201 | 0.1259 |
Entamoeba histolytica | purine nucleoside phosphorylase, putative | 0.0117 | 0.1201 | 0.5 |
Trichomonas vaginalis | purine nucleoside phosphorylase, putative | 0.0117 | 0.1201 | 0.5 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0117 | 0.1201 | 0.1201 |
Leishmania major | nucleoside phosphorylase-like protein | 0.0117 | 0.1201 | 0.1002 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0117 | 0.1201 | 0.1259 |
Loa Loa (eye worm) | hypothetical protein | 0.0125 | 0.134 | 0.134 |
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.0849 | 0.0849 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0117 | 0.1201 | 0.1201 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0117 | 0.1201 | 0.5 |
Entamoeba histolytica | purine nucleoside phosphorylase, putative | 0.0117 | 0.1201 | 0.5 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0117 | 0.1201 | 0.1201 |
Trichomonas vaginalis | purine nucleoside phosphorylase, putative | 0.0117 | 0.1201 | 0.5 |
Trypanosoma cruzi | methylthioadenosine phosphorylase, putative | 0.0633 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0148 | 0.172 | 0.172 |
Entamoeba histolytica | hypothetical protein | 0.0117 | 0.1201 | 0.5 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0097 | 0.0849 | 0.0849 |
Toxoplasma gondii | Purine nucleoside phosphorylase | 0.0117 | 0.1201 | 1 |
Mycobacterium leprae | probable uridine phosphorylase | 0.0117 | 0.1201 | 0.5 |
Mycobacterium tuberculosis | Probable 5'-methylthioadenosine phosphorylase Pnp (MTA phosphorylase) | 0.0516 | 0.8001 | 1 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0117 | 0.1201 | 0.1201 |
Onchocerca volvulus | Huntingtin homolog | 0.0125 | 0.134 | 0.2688 |
Loa Loa (eye worm) | hypothetical protein | 0.0125 | 0.134 | 0.134 |
Mycobacterium ulcerans | purine nucleoside phosphorylase | 0.0117 | 0.1201 | 0.1002 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0117 | 0.1201 | 0.1201 |
Giardia lamblia | Purine nucleoside phosphorylase lateral transfer candidate | 0.0117 | 0.1201 | 0.5 |
Trypanosoma cruzi | methylthioadenosine phosphorylase, putative | 0.0633 | 1 | 1 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0117 | 0.1201 | 0.1201 |
Loa Loa (eye worm) | uridine phosphorylase | 0.0117 | 0.1201 | 0.1201 |
Toxoplasma gondii | phosphorylase family protein | 0.0117 | 0.1201 | 1 |
Giardia lamblia | 5-methylthioadenosine nucleosidase, S-adenosylhomocysteine nucleosidase | 0.0117 | 0.1201 | 0.5 |
Entamoeba histolytica | purine nucleoside phosphorylase, putative | 0.0117 | 0.1201 | 0.5 |
Chlamydia trachomatis | AMP nucleosidase | 0.0117 | 0.1201 | 0.5 |
Mycobacterium ulcerans | bifunctional Mta/Sah nucleosidase Mtn | 0.0117 | 0.1201 | 0.1002 |
Brugia malayi | hypothetical protein | 0.0125 | 0.134 | 0.134 |
Onchocerca volvulus | Huntingtin homolog | 0.0125 | 0.134 | 0.2688 |
Loa Loa (eye worm) | S-methyl-5'-thioadenosine phosphorylase MTAP | 0.0633 | 1 | 1 |
Treponema pallidum | purine nucleoside phosphorylase (deoD) | 0.0117 | 0.1201 | 0.5 |
Toxoplasma gondii | phosphorylase family protein | 0.0117 | 0.1201 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0173 | 0.216 | 0.216 |
Plasmodium vivax | purine nucleoside phosphorylase, putative | 0.0117 | 0.1201 | 0.5 |
Schistosoma mansoni | methylthioadenosine phosphorylase | 0.0117 | 0.1201 | 0.1201 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.0327 | 0.0327 |
Trichomonas vaginalis | purine nucleoside phosphorylase I, putative | 0.0117 | 0.1201 | 0.5 |
Echinococcus granulosus | uridine phosphorylase 1 | 0.0117 | 0.1201 | 0.1201 |
Trichomonas vaginalis | purine nucleoside phosphorylase, putative | 0.0117 | 0.1201 | 0.5 |
Mycobacterium leprae | Probable purine nucleoside phosphorylase DeoD (INOSINE PHOSPHORYLASE) (PNP) | 0.0117 | 0.1201 | 0.5 |
Entamoeba histolytica | MTA/SAH nucleosidase, putative | 0.0117 | 0.1201 | 0.5 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0122 | 0.1286 | 0.1286 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0066 | 0.0327 | 0.0327 |
Schistosoma mansoni | hypothetical protein | 0.0173 | 0.216 | 0.216 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.006 | 0.0221 | 0.0221 |
Entamoeba histolytica | purine nucleoside phosphorylase, putative | 0.0117 | 0.1201 | 0.5 |
Echinococcus granulosus | geminin | 0.0173 | 0.216 | 0.216 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0097 | 0.0849 | 0.0849 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0117 | 0.1201 | 0.1201 |
Schistosoma mansoni | uridine phosphorylase | 0.0117 | 0.1201 | 0.1201 |
Trichomonas vaginalis | purine nucleoside phosphorylase, putative | 0.0117 | 0.1201 | 0.5 |
Mycobacterium tuberculosis | Probable purine nucleoside phosphorylase DeoD (inosine phosphorylase) (PNP) | 0.0117 | 0.1201 | 0.1259 |
Entamoeba histolytica | purine nucleoside phosphorylase, putative | 0.0117 | 0.1201 | 0.5 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0117 | 0.1201 | 0.1201 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0117 | 0.1201 | 0.1201 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.006 | 0.0221 | 0.0221 |
Treponema pallidum | uridine phosphorylase (udp) | 0.0117 | 0.1201 | 0.5 |
Plasmodium falciparum | purine nucleoside phosphorylase | 0.0117 | 0.1201 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.