Detailed information for compound 546540

Basic information

Technical information
  • TDR Targets ID: 546540
  • Name: [[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dih ydroxy-tetrahydrofuran-2-yl]methoxy-hydroxy-p hosphoryl] [[(5-bromo-4-chloro-1H-indol-3-yl) oxy-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl ] hydrogen phosphate
  • MW: 815.634 | Formula: C18H20BrClN6O16P4
  • H donors: 8 H acceptors: 13 LogP: -3.04 Rotable bonds: 12
    Rule of 5 violations (Lipinski): 4
  • SMILES: O[C@@H]1[C@H](O)[C@H](O[C@H]1n1cnc2c1ncnc2N)COP(=O)(OP(=O)(OP(=O)(OP(=O)(Oc1c[nH]c2c1c(Cl)c(cc2)Br)O)O)O)O
  • InChi: 1S/C18H20BrClN6O16P4/c19-7-1-2-8-11(12(7)20)9(3-22-8)39-44(31,32)41-46(35,36)42-45(33,34)40-43(29,30)37-4-10-14(27)15(28)18(38-10)26-6-25-13-16(21)23-5-24-17(13)26/h1-3,5-6,10,14-15,18,22,27-28H,4H2,(H,29,30)(H,31,32)(H,33,34)(H,35,36)(H2,21,23,24)/t10-,14-,15-,18-/m1/s1
  • InChiKey: FUAAYYAFMCNVGN-YVLZZHOMSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • [[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxy-2-tetrahydrofuranyl]methoxy-hydroxyphosphoryl] [[(5-bromo-4-chloro-1H-indol-3-yl)oxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl] hydrogen phosphate
  • [[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxy-oxolan-2-yl]methoxy-hydroxy-phosphoryl] [[(5-bromo-4-chloro-1H-indol-3-yl)oxy-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl] hydrogen phosphate
  • [[(2R,3S,4R,5R)-5-adenin-9-yl-3,4-dihydroxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl] [[(5-bromo-4-chloro-1H-indol-3-yl)oxy-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl] hydrogen phosphate
  • [[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [[(5-bromo-4-chloro-1H-indol-3-yl)oxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl] hydrogen phosphate
  • 5-bromo-4-chloro-3-indolyltetraphospho-5'-adenosine
  • [(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl [[[(5-bromo-4-chloro-1H-indol-3-yl)oxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl] hydrogen phosphate
  • [(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methyl [[[(5-bromo-4-chloro-1H-indol-3-yl)oxy-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl] hydrogen phosphate
  • [(2R,3S,4R,5R)-5-(6-amino-9-purinyl)-3,4-dihydroxy-2-tetrahydrofuranyl]methyl [[[(5-bromo-4-chloro-1H-indol-3-yl)oxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl] hydrogen phosphate
  • [(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxy-oxolan-2-yl]methyl [[[(5-bromo-4-chloro-1H-indol-3-yl)oxy-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl] hydrogen phosphate
  • 148778-60-3
  • Bcip4A
  • 5-Bromo-4-chloro-3-indolyl tetraphospho-5'-adenosine

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii hypothetical protein 0.0042 0.0303 0.2313
Echinococcus multilocularis Membrane bound O acyl transferase, MBOAT 0.0042 0.0303 0.0297
Trichomonas vaginalis esterase, putative 0.0039 0.0278 0.0832
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0022 0.0084 0.5
Echinococcus granulosus beta LACTamase domain containing family member 0.0039 0.0278 0.0272
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0022 0.0084 0.1579
Schistosoma mansoni cpg binding protein 0.0065 0.0558 0.053
Echinococcus granulosus pyruvate kinase 0.0017 0.003 0.0024
Echinococcus granulosus GPCR family 2 0.0036 0.0237 0.0231
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0205 0.0101
Trichomonas vaginalis ap endonuclease, putative 0.0022 0.0084 0.0237
Trichomonas vaginalis glutaminase, putative 0.031 0.3265 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0099 0.094 0.0935
Loa Loa (eye worm) CXXC zinc finger family protein 0.0065 0.0558 0.1058
Echinococcus granulosus lamin 0.003 0.0178 0.0172
Echinococcus multilocularis dnaJ subfamily B 0.0922 1 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0278 0.0527
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0022 0.0084 0.3078
Trypanosoma cruzi pyruvate kinase 2, putative 0.0033 0.0205 0.6243
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0017 0.0037 0.003
Brugia malayi glutaminase DH11.1 0.031 0.3265 0.617
Loa Loa (eye worm) hypothetical protein 0.0042 0.0303 0.0574
Brugia malayi Pyruvate kinase, M2 isozyme 0.0033 0.0205 0.0346
Loa Loa (eye worm) hypothetical protein 0.0042 0.0303 0.0574
Trypanosoma cruzi GUP1, putative 0.0042 0.0303 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0099 0.094 0.1782
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0018 0.0043 0.0037
Loa Loa (eye worm) latrophilin receptor protein 2 0.0036 0.0237 0.0449
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0018 0.0043 0.0472
Loa Loa (eye worm) membrane bound O-acyltransferase domain containing 1 0.0042 0.0303 0.0574
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0205 0.0389
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0303 0.0909
Onchocerca volvulus 0.0065 0.0558 0.1414
Trichomonas vaginalis pyruvate kinase, putative 0.0033 0.0205 0.0609
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0278 0.0832
Loa Loa (eye worm) MBOAT family protein 0.0042 0.0303 0.0574
Loa Loa (eye worm) hypothetical protein 0.0042 0.0303 0.0574
Plasmodium falciparum pyruvate kinase 0.0033 0.0205 0.642
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0036 0.0237 0.0231
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0022 0.0084 0.1976
Brugia malayi MBOAT family protein 0.0042 0.0303 0.0532
Echinococcus granulosus mixed lineage leukemia protein mll 0.0017 0.0037 0.003
Plasmodium vivax SET domain protein, putative 0.0036 0.024 0.7684
Mycobacterium ulcerans beta-lactamase 0.0039 0.0278 0.0609
Echinococcus multilocularis isocitrate dehydrogenase 0.0018 0.0043 0.0037
Mycobacterium tuberculosis Probable lipase LipD 0.0039 0.0278 0.0915
Toxoplasma gondii acyl-CoA:cholesterol acyltransferase alpha ACAT1-alpha 0.0042 0.0303 0.2313
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0042 0.0303 0.0274
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0022 0.0084 0.016
Schistosoma mansoni ap endonuclease 0.0022 0.0084 0.0054
Trypanosoma cruzi pyruvate kinase 2, putative 0.0033 0.0205 0.6243
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0021 0.008 0.0074
Mycobacterium tuberculosis Probable lipase LipE 0.0039 0.0278 0.0915
Schistosoma mansoni cpg binding protein 0.0068 0.0599 0.0571
Echinococcus granulosus Membrane bound O acyl transferase MBOAT 0.0042 0.0303 0.0297
Loa Loa (eye worm) hypothetical protein 0.0077 0.0692 0.131
Trypanosoma brucei glycerol uptake protein, putative 0.0042 0.0303 1
Onchocerca volvulus 0.0039 0.0278 0.0371
Leishmania major glycerol uptake protein, putative 0.0042 0.0303 1
Echinococcus multilocularis lamin 0.003 0.0178 0.0172
Loa Loa (eye worm) glutaminase 0.031 0.3265 0.6187
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0022 0.0084 0.0078
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0042 0.0303 0.0297
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0099 0.094 0.0913
Brugia malayi Pre-SET motif family protein 0.0036 0.024 0.0411
Echinococcus multilocularis membrane bound acyltransferase:hhat 0.0042 0.0303 0.0297
Chlamydia trachomatis pyruvate kinase 0.0033 0.0205 0.5
Echinococcus multilocularis protein cysteine N palmitoyltransferase 0.0482 0.5156 0.5153
Schistosoma mansoni glutaminase 0.031 0.3265 0.3245
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0278 0.0832
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0278 0.0832
Schistosoma mansoni hypothetical protein 0.0081 0.0736 0.0707
Onchocerca volvulus 0.0036 0.024 0.0229
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0039 0.0278 0.0484
Onchocerca volvulus 0.0274 0.2867 1
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0022 0.0084 0.1579
Plasmodium falciparum diacylglycerol O-acyltransferase 0.0042 0.0303 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0036 0.024 0.0234
Loa Loa (eye worm) hypothetical protein 0.0036 0.024 0.0455
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0278 0.0249
Schistosoma mansoni leukocyte receptor cluster (lrc) member 4 protein 0.0042 0.0303 0.0274
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0022 0.0084 0.0078
Plasmodium vivax hypothetical protein, conserved 0.0039 0.0278 0.908
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0018 0.0043 0.0037
Brugia malayi beta-lactamase 0.0039 0.0278 0.0484
Brugia malayi MBOAT family protein 0.0042 0.0303 0.0532
Schistosoma mansoni zinc finger protein 0.0482 0.5156 0.5142
Onchocerca volvulus 0.0039 0.0278 0.0371
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0099 0.094 0.0935
Toxoplasma gondii acyl-CoA:diacylglycerol acyltransferase 1-related enzyme 0.0042 0.0303 0.2313
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0278 0.9034
Loa Loa (eye worm) intermediate filament protein 0.003 0.0178 0.0338
Brugia malayi MBOAT family protein 0.0482 0.5156 0.977
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0042 0.0303 0.0297
Onchocerca volvulus 0.0039 0.0278 0.0371
Toxoplasma gondii pyruvate kinase PyK1 0.0033 0.0205 0.1485
Brugia malayi Calcitonin receptor-like protein seb-1 0.0112 0.1083 0.2016
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0303 0.0909
Loa Loa (eye worm) hypothetical protein 0.0042 0.0303 0.0574
Mycobacterium tuberculosis Probable esterase LipL 0.0039 0.0278 0.0915
Loa Loa (eye worm) hypothetical protein 0.0039 0.0278 0.0527
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0043 0.0037
Echinococcus granulosus sterol O acyltransferase 1 0.0042 0.0303 0.0297
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0039 0.0278 0.0915
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0018 0.0043 0.0013
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0033 0.021 0.0204
Brugia malayi beta-lactamase family protein 0.0039 0.0278 0.0484
Trypanosoma brucei hypothetical protein, conserved 0.0039 0.0278 0.9034
Loa Loa (eye worm) hypothetical protein 0.0036 0.0237 0.0449
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0018 0.0043 0.0472
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0021 0.008 0.0074
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0081 0.0736 0.073
Entamoeba histolytica hypothetical protein, conserved 0.0042 0.0303 0.3362
Schistosoma mansoni hypothetical protein 0.0195 0.1996 0.1972
Brugia malayi follicle stimulating hormone receptor 0.0263 0.2743 0.5176
Loa Loa (eye worm) diacylglycerol acyltransferase 0.0042 0.0303 0.0574
Echinococcus granulosus zinc finger protein 0.0441 0.4699 0.4695
Brugia malayi Isocitrate dehydrogenase 0.0018 0.0043 0.0037
Echinococcus multilocularis pyruvate kinase 0.0017 0.003 0.0024
Treponema pallidum alginate O-acetylation protein (algI) 0.0042 0.0303 1
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.024 0.0234
Leishmania major hypothetical protein, conserved 0.0039 0.0278 0.9034
Loa Loa (eye worm) MBOAT family protein 0.0482 0.5156 0.9771
Schistosoma mansoni hypothetical protein 0.0077 0.0692 0.0663
Loa Loa (eye worm) hypothetical protein 0.003 0.0172 0.0326
Schistosoma mansoni transcription factor LCR-F1 0.0081 0.0736 0.0707
Echinococcus granulosus intermediate filament protein 0.003 0.0178 0.0172
Mycobacterium leprae conserved hypothetical protein 0.0039 0.0278 1
Loa Loa (eye worm) hypothetical protein 0.0055 0.045 0.0853
Entamoeba histolytica hypothetical protein 0.0081 0.0736 1
Schistosoma mansoni sterol O-acyltransferase 1 0.0042 0.0303 0.0274
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0303 0.0909
Mycobacterium tuberculosis Conserved protein 0.0039 0.0278 0.0915
Brugia malayi Latrophilin receptor protein 2 0.0036 0.0237 0.0406
Echinococcus multilocularis pyruvate kinase 0.0017 0.003 0.0024
Brugia malayi Pre-SET motif family protein 0.0241 0.2502 0.4718
Mycobacterium leprae Probable lipase LipE 0.0039 0.0278 1
Loa Loa (eye worm) pyruvate kinase-PB 0.0023 0.0097 0.0183
Mycobacterium tuberculosis Probable hydrolase 0.0039 0.0278 0.0915
Loa Loa (eye worm) hhat protein 0.0042 0.0303 0.0574
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.024 0.021
Trichomonas vaginalis transmembrane protein nessy, putative 0.0042 0.0303 0.0909
Echinococcus granulosus o acyltransferase membrane bound domain 0.0042 0.0303 0.0297
Echinococcus granulosus lamin dm0 0.003 0.0178 0.0172
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0039 0.0278 0.0915
Leishmania major glycerol uptake protein, putative 0.0042 0.0303 1
Loa Loa (eye worm) hhat protein 0.0042 0.0303 0.0574
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0278 0.0832
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0205 0.0101
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0042 0.0303 0.3362
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0022 0.0084 0.1976
Entamoeba histolytica vacuolar protein sorting 26 0.0042 0.0303 0.3362
Echinococcus multilocularis beta LACTamase domain containing family member 0.0039 0.0278 0.0272
Schistosoma mansoni membrane-bound acyltransferase/hhat 0.0042 0.0303 0.0274
Schistosoma mansoni hypothetical protein 0.0036 0.0237 0.0207
Brugia malayi Pyruvate kinase, muscle isozyme 0.0033 0.0205 0.0346
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0039 0.0278 0.0609
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0099 0.094 0.0935
Schistosoma mansoni hypothetical protein 0.0036 0.0237 0.0207
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.024 0.1777
Brugia malayi F/Y-rich N-terminus family protein 0.0021 0.0077 0.0102
Echinococcus multilocularis muscleblind protein 1 0.0493 0.5277 0.5274
Schistosoma mansoni pyruvate kinase 0.0033 0.0205 0.0176
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0205 0.0389
Trypanosoma cruzi glycerol uptake protein, putative 0.0042 0.0303 1
Loa Loa (eye worm) MBOAT family protein 0.0042 0.0303 0.0574
Brugia malayi latrophilin 2 splice variant baaae 0.0077 0.0692 0.1271
Schistosoma mansoni cpg binding protein 0.0068 0.0599 0.0571
Brugia malayi hypothetical protein 0.0081 0.0736 0.1355
Echinococcus granulosus cpg binding protein 0.0068 0.0599 0.0593
Loa Loa (eye worm) glutaminase 2 0.031 0.3265 0.6187
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0039 0.0278 0.0527
Plasmodium vivax pyruvate kinase, putative 0.0033 0.0205 0.642
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0099 0.094 0.0935
Loa Loa (eye worm) hypothetical protein 0.0039 0.0278 0.0527
Schistosoma mansoni ap endonuclease 0.0022 0.0084 0.0054
Trichomonas vaginalis ap endonuclease, putative 0.0022 0.0084 0.0237
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0081 0.0736 0.073
Brugia malayi CXXC zinc finger family protein 0.0065 0.0558 0.1018
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0043 0.0037
Loa Loa (eye worm) hypothetical protein 0.0112 0.1083 0.2052
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0036 0.0237 0.0231
Mycobacterium ulcerans glutaminase 0.031 0.3265 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0099 0.094 0.0913
Echinococcus multilocularis sterol O acyltransferase 1 0.0042 0.0303 0.0297
Echinococcus granulosus pyruvate kinase 0.0033 0.0205 0.0199
Brugia malayi beta-lactamase family protein 0.0039 0.0278 0.0484
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0241 0.2502 0.4742
Echinococcus multilocularis pyruvate kinase 0.0017 0.003 0.0024
Echinococcus granulosus o acyltransferase membrane bound domain 0.0042 0.0303 0.0297
Toxoplasma gondii ABC1 family protein 0.0039 0.0278 0.21
Trichomonas vaginalis pyruvate kinase, putative 0.0033 0.0205 0.0609
Schistosoma mansoni lamin 0.003 0.0178 0.0148
Entamoeba histolytica hypothetical protein 0.0042 0.0303 0.3362
Brugia malayi exodeoxyribonuclease III family protein 0.0022 0.0084 0.0115
Schistosoma mansoni hypothetical protein 0.0195 0.1996 0.1972
Schistosoma mansoni lamin 0.003 0.0178 0.0148
Schistosoma mansoni hypothetical protein 0.0922 1 1
Echinococcus multilocularis lamin dm0 0.003 0.0178 0.0172
Echinococcus multilocularis muscleblind protein 0.0493 0.5277 0.5274
Loa Loa (eye worm) hypothetical protein 0.0493 0.5277 1
Echinococcus multilocularis cpg binding protein 0.0068 0.0599 0.0593
Entamoeba histolytica pyruvate kinase, putative 0.0023 0.0097 0.019
Echinococcus multilocularis GPCR, family 2 0.0036 0.0237 0.0231
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0022 0.0084 0.1579
Brugia malayi MBOAT family protein 0.0042 0.0303 0.0532
Toxoplasma gondii isocitrate dehydrogenase 0.0018 0.0043 0.0109
Brugia malayi isocitrate dehydrogenase 0.0018 0.0043 0.0037
Echinococcus granulosus protein cysteine N palmitoyltransferase 0.0482 0.5156 0.5153
Leishmania major pyruvate kinase 0.0033 0.0205 0.6243
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0042 0.0303 0.3362
Trypanosoma brucei pyruvate kinase 1 0.0033 0.0205 0.6243
Echinococcus granulosus tumor protein p63 0.0375 0.3978 0.3974
Loa Loa (eye worm) hypothetical protein 0.0039 0.0278 0.0527
Toxoplasma gondii histone lysine methyltransferase SET1 0.0124 0.121 1
Echinococcus granulosus muscleblind protein 0.0493 0.5277 0.5274
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0099 0.094 0.1744
Leishmania major hypothetical protein, conserved 0.0042 0.0303 1
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0205 0.0389
Loa Loa (eye worm) hypothetical protein 0.0039 0.0278 0.0527
Echinococcus granulosus geminin 0.0195 0.1996 0.1991
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0139 0.1372 0.1346
Trichomonas vaginalis set domain proteins, putative 0.0274 0.2867 0.8779
Brugia malayi Muscleblind-like protein 0.0493 0.5277 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0099 0.094 0.0913
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0042 0.0303 0.0274
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0278 0.0832
Echinococcus multilocularis musashi 0.003 0.0178 0.0172
Echinococcus granulosus membrane bound acyltransferase:hhat 0.0042 0.0303 0.0297
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.003 0.0178 0.0338
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0251 0.2609 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0278 0.0527
Echinococcus multilocularis pyruvate kinase 0.0033 0.0205 0.0199
Loa Loa (eye worm) hypothetical protein 0.0015 0.0006 0.0012
Trypanosoma brucei pyruvate kinase 1, putative 0.0033 0.0205 0.6243
Echinococcus multilocularis pyruvate kinase 0.0033 0.0205 0.0199
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0036 0.024 0.021
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0036 0.024 0.0234
Schistosoma mansoni intermediate filament proteins 0.003 0.0178 0.0148
Loa Loa (eye worm) hypothetical protein 0.0023 0.0097 0.0183
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0022 0.0084 0.016
Toxoplasma gondii exonuclease III APE 0.0022 0.0084 0.0457
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0042 0.0303 0.0297
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0278 0.0249
Brugia malayi MBOAT family protein 0.0042 0.0303 0.0532
Giardia lamblia Pyruvate kinase 0.0033 0.0205 1
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.0024 0.0045
Toxoplasma gondii isocitrate dehydrogenase 0.0018 0.0043 0.0109
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0043 0.0037
Trypanosoma cruzi GUP1, putative 0.0042 0.0303 1
Mycobacterium ulcerans pyruvate kinase 0.0033 0.0205 0.0381
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0042 0.0303 0.3362
Schistosoma mansoni hypothetical protein 0.0036 0.0237 0.0207
Echinococcus granulosus lysophospholipid acyltransferase 7 0.0042 0.0303 0.0297
Loa Loa (eye worm) isocitrate dehydrogenase 0.0018 0.0043 0.0082
Brugia malayi diacylglycerol acyltransferase 0.0042 0.0303 0.0532
Mycobacterium ulcerans hypothetical protein 0.0039 0.0278 0.0609
Echinococcus multilocularis diacylglycerol O acyltransferase 1 0.0042 0.0303 0.0297
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.024 0.021
Leishmania major glycerol uptake protein, putative 0.0042 0.0303 1
Entamoeba histolytica hypothetical protein 0.0081 0.0736 1
Leishmania major glycerol uptake protein, putative 0.0042 0.0303 1
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0263 0.2743 0.5197
Mycobacterium ulcerans esterase/lipase LipP 0.0039 0.0278 0.0609
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0036 0.0237 0.0406
Mycobacterium tuberculosis Conserved protein 0.0039 0.0278 0.0915
Loa Loa (eye worm) hypothetical protein 0.003 0.0178 0.0338
Loa Loa (eye worm) hypothetical protein 0.0033 0.0205 0.0389
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0017 0.0037 0.0006
Leishmania major glycerol uptake protein, putative 0.0042 0.0303 1
Echinococcus granulosus pyruvate kinase 0.0017 0.003 0.0024
Loa Loa (eye worm) beta-lactamase 0.0039 0.0278 0.0527
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0036 0.0237 0.0231
Brugia malayi Hhat protein 0.0042 0.0303 0.0532
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0017 0.0037 0.003
Trypanosoma cruzi glycerol uptake protein, putative 0.0042 0.0303 1
Echinococcus granulosus diacylglycerol O acyltransferase 1 0.0042 0.0303 0.0297
Schistosoma mansoni diacylglycerol O-acyltransferase 1 0.0042 0.0303 0.0274
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0033 0.0205 0.0633
Mycobacterium ulcerans lipase LipD 0.0039 0.0278 0.0609
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0022 0.0084 0.1579
Echinococcus multilocularis zinc finger protein 0.0441 0.4699 0.4695
Trypanosoma cruzi glycerol uptake protein, putative 0.0042 0.0303 1
Schistosoma mansoni hypothetical protein 0.0036 0.0237 0.0207
Trichomonas vaginalis porcupine, putative 0.0042 0.0303 0.0909
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0112 0.1083 0.2016
Onchocerca volvulus 0.0055 0.045 0.1012
Plasmodium vivax diacylglycerol O-acyltransferase, putative 0.0042 0.0303 1
Brugia malayi intermediate filament protein 0.003 0.0178 0.0294
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0278 0.9034
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0042 0.0303 0.0274
Brugia malayi Intermediate filament tail domain containing protein 0.003 0.0178 0.0294
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0112 0.1083 0.2052
Loa Loa (eye worm) histone methyltransferase 0.0021 0.008 0.0152
Echinococcus granulosus pyruvate kinase 0.0017 0.003 0.0024
Onchocerca volvulus 0.0042 0.0303 0.0464
Schistosoma mansoni hypothetical protein 0.0042 0.0303 0.0274
Mycobacterium tuberculosis Conserved protein 0.0039 0.0278 0.0915
Trypanosoma brucei glycerol uptake protein, putative 0.0042 0.0303 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0036 0.0237 0.0231
Echinococcus multilocularis tumor protein p63 0.0375 0.3978 0.3974
Loa Loa (eye worm) hypothetical protein 0.0493 0.5277 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.024 0.021
Echinococcus granulosus pyruvate kinase 0.0033 0.0205 0.0199
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0205 0.0101
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0039 0.0278 0.0915
Entamoeba histolytica hypothetical protein 0.0081 0.0736 1
Echinococcus multilocularis geminin 0.0195 0.1996 0.1991
Schistosoma mansoni pyruvate kinase 0.0033 0.0205 0.0176
Echinococcus granulosus o acyltransferase membrane bound domain 0.0042 0.0303 0.0297
Echinococcus multilocularis pyruvate kinase 0.0026 0.013 0.0124
Echinococcus multilocularis lysophospholipid acyltransferase 7 0.0042 0.0303 0.0297
Schistosoma mansoni cellular tumor antigen P53 0.0055 0.045 0.0421
Entamoeba histolytica hypothetical protein 0.0081 0.0736 1
Leishmania major pyruvate kinase 0.0033 0.0205 0.6243
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0017 0.0037 0.003

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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