Detailed information for compound 549465

Basic information

Technical information
  • TDR Targets ID: 549465
  • Name: (2S,4S,5R,6R)-5-acetamido-4-acetoxy-2-hydroxy -6-[(1R,2R)-1,2,3-trihydroxypropyl]tetrahydro pyran-2-carboxylic acid
  • MW: 351.307 | Formula: C13H21NO10
  • H donors: 6 H acceptors: 8 LogP: -2.89 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 2
  • SMILES: OC[C@H]([C@H]([C@@H]1O[C@@](O)(C[C@@H]([C@H]1NC(=O)C)OC(=O)C)C(=O)O)O)O
  • InChi: 1S/C13H21NO10/c1-5(16)14-9-8(23-6(2)17)3-13(22,12(20)21)24-11(9)10(19)7(18)4-15/h7-11,15,18-19,22H,3-4H2,1-2H3,(H,14,16)(H,20,21)/t7-,8+,9-,10-,11-,13+/m1/s1
  • InChiKey: LVBIMVQYUKOENY-XAGGSGLKSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (2S,4S,5R,6R)-5-acetamido-4-acetoxy-2-hydroxy-6-[(1R,2R)-1,2,3-trihydroxypropyl]-2-tetrahydropyrancarboxylic acid
  • (2S,4S,5R,6R)-5-acetamido-4-acetyloxy-2-hydroxy-6-[(1R,2R)-1,2,3-trihydroxypropyl]oxane-2-carboxylic acid
  • 4-O-acetyl-N-acetylneuraminic acid
  • 16655-75-7
  • 29979-14-4
  • D-glycero-D-galacto-2-Nonulosonic acid, 5-(acetylamino)-3,5-dideoxy-, 4-acetate
  • 5-acetamido-4-O-acetyl-3,5-dideoxy-D-glycero-beta-D-galacto-non-2-ulopyranosonic acid
  • CHEBI:32844
  • N-acetyl-4-O-acetylneuraminic acid

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis aldo keto reductase 0.0867 0.9188 0.9188
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0346 0.0346
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0867 0.9188 0.9188
Loa Loa (eye worm) DR-78 0.0039 0.0285 0.0285
Onchocerca volvulus 0.016 0.159 0.1343
Entamoeba histolytica acetyltransferase, GNAT family 0.0038 0.0279 0.0304
Loa Loa (eye worm) solute carrier family 6 member 4 0.0943 1 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.0346 0.0346
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0115 0.1108 0.1108
Brugia malayi hypothetical protein 0.016 0.159 0.159
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0082 0.075 0.075
Echinococcus granulosus histone acetyltransferase KAT2B 0.0137 0.1345 0.1345
Schistosoma mansoni hypothetical protein 0.0015 0.0035 0.0035
Leishmania major aldo-keto reductase-like protein 0.0867 0.9188 1
Echinococcus multilocularis muscleblind protein 0.029 0.2987 0.2987
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0082 0.075 0.075
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0867 0.9188 0.9188
Echinococcus granulosus Nuclear hormone receptor HR96 0.0039 0.0285 0.0285
Loa Loa (eye worm) hypothetical protein 0.0082 0.075 0.075
Loa Loa (eye worm) hypothetical protein 0.0039 0.0285 0.0285
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0115 0.1108 0.1108
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0082 0.075 0.075
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0867 0.9188 0.9188
Echinococcus multilocularis aldo keto reductase 0.0867 0.9188 0.9188
Schistosoma mansoni zinc finger protein 0.0039 0.0285 0.0285
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.016 0.159 0.159
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0082 0.075 0.075
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.016 0.159 0.159
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0043 0.0335 0.0335
Brugia malayi Nuclear hormone receptor E75 0.0039 0.0285 0.0285
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0867 0.9188 0.9188
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.016 0.159 0.5
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0039 0.0285 0.0285
Schistosoma mansoni RAR-like nuclear receptor 0.0082 0.075 0.075
Toxoplasma gondii oxidoreductase, aldo/keto reductase family protein 0.0251 0.2569 0.2796
Loa Loa (eye worm) hypothetical protein 0.0082 0.075 0.075
Trichomonas vaginalis aldo-keto reductase, putative 0.0867 0.9188 1
Leishmania major aldehyde reductase, putative,oxidoreductase, putative 0.0867 0.9188 1
Schistosoma mansoni thyroid hormone receptor 0.0082 0.075 0.075
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0346 0.0346
Plasmodium falciparum transporter, putative 0.016 0.159 0.6188
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.0035 0.0035
Trichomonas vaginalis aldo-keto reductase, putative 0.0867 0.9188 1
Loa Loa (eye worm) oxidoreductase 0.0867 0.9188 0.9188
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0943 1 1
Brugia malayi nuclear hormone receptor 0.0039 0.0285 0.0285
Entamoeba histolytica aldose reductase, putative 0.0867 0.9188 1
Echinococcus granulosus aldehyde reductase 0.0616 0.6489 0.6489
Loa Loa (eye worm) hypothetical protein 0.016 0.159 0.159
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0867 0.9188 0.9188
Loa Loa (eye worm) hypothetical protein 0.0043 0.0335 0.0335
Schistosoma mansoni thyroid hormone receptor 0.0082 0.075 0.075
Trichomonas vaginalis aldo-keto reductase, putative 0.0867 0.9188 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0867 0.9188 1
Loa Loa (eye worm) hypothetical protein 0.0943 1 1
Brugia malayi hypothetical protein 0.0039 0.0285 0.0285
Schistosoma mansoni pol-related 0.0867 0.9188 0.9188
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0082 0.075 0.075
Echinococcus granulosus ecdysone induced protein 78C 0.0082 0.075 0.075
Loa Loa (eye worm) hypothetical protein 0.0082 0.075 0.075
Mycobacterium leprae Conserved hypothetical protein 0.0616 0.6489 0.5922
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0039 0.0285 0.0285
Loa Loa (eye worm) hypothetical protein 0.0043 0.0335 0.0335
Brugia malayi nuclear hormone receptor family member odr-7 0.0039 0.0285 0.0285
Echinococcus multilocularis aldo keto reductase 0.0867 0.9188 0.9188
Plasmodium falciparum aldo-keto reductase, putative 0.0251 0.2569 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0082 0.075 0.075
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0115 0.1108 0.1108
Loa Loa (eye worm) hypothetical protein 0.016 0.159 0.159
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0039 0.0285 0.0285
Entamoeba histolytica alcohol dehydrogenase, putative 0.0251 0.2569 0.2796
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0035 0.0035
Mycobacterium tuberculosis Probable oxidoreductase 0.0867 0.9188 1
Echinococcus granulosus nuclear receptor nhr 48 0.0039 0.0285 0.0285
Schistosoma mansoni hypothetical protein 0.0015 0.0035 0.0035
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0039 0.0285 0.0285
Onchocerca volvulus 0.0867 0.9188 0.9164
Trichomonas vaginalis aldo-keto reductase, putative 0.0867 0.9188 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0082 0.075 0.075
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0039 0.0285 0.0285
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0082 0.075 0.0478
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0082 0.075 0.075
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0867 0.9188 0.9188
Schistosoma mansoni nuclear receptor 0.0039 0.0285 0.0285
Loa Loa (eye worm) hypothetical protein 0.0043 0.0335 0.0335
Echinococcus granulosus voltage gated potassium channel subunit 0.0251 0.2569 0.2569
Loa Loa (eye worm) acetyltransferase 0.0141 0.1387 0.1387
Brugia malayi Muscleblind-like protein 0.029 0.2987 0.2987
Onchocerca volvulus 0.0082 0.075 0.0478
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0039 0.0285 0.0285
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0042 0.0316 0.0344
Loa Loa (eye worm) oxidoreductase 0.0867 0.9188 0.9188
Loa Loa (eye worm) hypothetical protein 0.029 0.2987 0.2987
Trypanosoma brucei prostaglandin f synthase 0.0867 0.9188 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0867 0.9188 0.9188
Loa Loa (eye worm) glutamate-cysteine ligase modifier subunit 0.0251 0.2569 0.2569
Brugia malayi orphan nuclear receptor NR2E1 0.0039 0.0285 0.0285
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.016 0.159 0.159
Giardia lamblia Histone acetyltransferase GCN5 0.0038 0.0279 0.0304
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0082 0.075 0.075
Echinococcus granulosus serotonin transporter 0.0943 1 1
Schistosoma mansoni nuclear hormone receptor 0.0082 0.075 0.075
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0867 0.9188 0.9188
Loa Loa (eye worm) hypothetical protein 0.0039 0.0285 0.0285
Brugia malayi ecdysteroid receptor 0.0082 0.075 0.075
Loa Loa (eye worm) nuclear receptor NHR-67 0.0039 0.0285 0.0285
Loa Loa (eye worm) hypothetical protein 0.0015 0.0035 0.0035
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.016 0.159 0.159
Trypanosoma cruzi aldo/keto reductase, putative 0.0867 0.9188 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0043 0.0335 0.0335
Schistosoma mansoni retinoic acid receptor RXR 0.0082 0.075 0.075
Schistosoma mansoni nuclear receptor 0.0039 0.0285 0.0285
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.016 0.159 0.159
Echinococcus multilocularis FTZ F1 alpha 0.0082 0.075 0.075
Schistosoma mansoni sodium-dependent amino acid transporter 0.016 0.159 0.159
Loa Loa (eye worm) hypothetical protein 0.0943 1 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0285 0.0285
Trichomonas vaginalis aldo-keto reductase, putative 0.0867 0.9188 1
Echinococcus granulosus aldo keto reductase 0.0867 0.9188 0.9188
Brugia malayi nuclear hormone receptor 0.0082 0.075 0.075
Onchocerca volvulus 0.016 0.159 0.1343
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0039 0.0285 0.0285
Trypanosoma brucei aldo/keto reductase, putative 0.0251 0.2569 0.2796
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0082 0.075 0.075
Trypanosoma brucei aldo-keto reductase, putative 0.0867 0.9188 1
Brugia malayi nuclear receptor NHR-88 0.0082 0.075 0.075
Loa Loa (eye worm) oxidoreductase 0.0867 0.9188 0.9188
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0082 0.075 0.075
Entamoeba histolytica aldose reductase, putative 0.0867 0.9188 1
Mycobacterium ulcerans oxidoreductase 0.0867 0.9188 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0082 0.075 0.075
Echinococcus granulosus uncharacterized sodium dependent transporter 0.016 0.159 0.159
Entamoeba histolytica dual specificity protein phosphatase, putative 0.0565 0.5938 0.6462
Plasmodium vivax aldehyde reductase, putative 0.0251 0.2569 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0867 0.9188 0.9188
Schistosoma mansoni sodium/chloride dependent transporter 0.016 0.159 0.159
Loa Loa (eye worm) hypothetical protein 0.0039 0.0285 0.0285
Brugia malayi tailless protein 0.0039 0.0285 0.0285
Loa Loa (eye worm) hypothetical protein 0.0039 0.0285 0.0285
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0082 0.075 0.075
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.016 0.159 0.159
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0082 0.075 0.075
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0082 0.075 0.075
Trypanosoma cruzi aldo/keto reductase, putative 0.0251 0.2569 0.2796
Brugia malayi Steroid receptor seven-up type 2 0.0082 0.075 0.075
Onchocerca volvulus 0.0867 0.9188 0.9164
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0867 0.9188 1
Echinococcus multilocularis sodium and chloride dependent glycine 0.016 0.159 0.159
Trichomonas vaginalis bromodomain-containing protein, putative 0.0042 0.0316 0.0344
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0346 0.0346
Loa Loa (eye worm) hypothetical protein 0.0039 0.0285 0.0285
Plasmodium vivax hypothetical protein, conserved 0.016 0.159 0.6188
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0042 0.0316 0.0344
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0082 0.075 0.075
Toxoplasma gondii aldose reductase, putative 0.0867 0.9188 1
Loa Loa (eye worm) hypothetical protein 0.016 0.159 0.159
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0867 0.9188 0.9188
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0082 0.075 0.075
Entamoeba histolytica aldose reductase, putative 0.0867 0.9188 1
Echinococcus granulosus FTZ F1 alpha 0.0082 0.075 0.075
Loa Loa (eye worm) hypothetical protein 0.0039 0.0285 0.0285
Loa Loa (eye worm) hypothetical protein 0.0867 0.9188 0.9188
Trichomonas vaginalis aldo-keto reductase, putative 0.0251 0.2569 0.2796
Trichomonas vaginalis aldo-keto reductase, putative 0.0867 0.9188 1
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0043 0.0335 0.0335
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.016 0.159 0.159
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.016 0.159 0.173
Loa Loa (eye worm) hypothetical protein 0.0082 0.075 0.075
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0082 0.075 0.075
Echinococcus granulosus GPCR family 2 0.0015 0.0035 0.0035
Schistosoma mansoni coup transcription factor 0.0082 0.075 0.075
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0867 0.9188 0.9188
Leishmania major prostaglandin f synthase, putative 0.0867 0.9188 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0251 0.2569 0.2796
Loa Loa (eye worm) hypothetical protein 0.0943 1 1
Mycobacterium leprae PROBABLE OXIDOREDUCTASE 0.0867 0.9188 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0082 0.075 0.075
Loa Loa (eye worm) hypothetical protein 0.0043 0.0335 0.0335
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.0346 0.0346
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0043 0.0335 0.0335
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0392 0.0392
Schistosoma mansoni sodium/chloride dependent transporter 0.016 0.159 0.159
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0082 0.075 0.075
Echinococcus granulosus Nuclear hormone receptor HR96 0.0039 0.0285 0.0285
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0082 0.075 0.075
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0867 0.9188 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.0082 0.075 0.075
Loa Loa (eye worm) hypothetical protein 0.0039 0.0285 0.0285
Trichomonas vaginalis aldo-keto reductase, putative 0.0867 0.9188 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0285 0.0285
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0082 0.075 0.075
Brugia malayi NADH-dependent xylose reductase 0.0251 0.2569 0.2569
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0867 0.9188 0.9188
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0346 0.0346
Loa Loa (eye worm) hypothetical protein 0.0082 0.075 0.075
Brugia malayi hypothetical protein 0.0043 0.0335 0.0335
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0082 0.075 0.075
Loa Loa (eye worm) hypothetical protein 0.0043 0.0335 0.0335
Echinococcus granulosus sodium and chloride dependent glycine 0.016 0.159 0.159
Echinococcus multilocularis aldo keto reductase 0.0867 0.9188 0.9188
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0039 0.0285 0.0285
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0867 0.9188 0.9188
Onchocerca volvulus 0.016 0.159 0.1343
Echinococcus multilocularis nuclear receptor nhr 48 0.0039 0.0285 0.0285
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0867 0.9188 0.9188
Loa Loa (eye worm) hypothetical protein 0.016 0.159 0.159
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0392 0.0392
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0392 0.0392
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0082 0.075 0.075
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0082 0.075 0.075
Schistosoma mansoni hypothetical protein 0.0015 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0082 0.075 0.075
Brugia malayi steroid hormone receptor 0.0082 0.075 0.075
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0115 0.1108 0.1108
Loa Loa (eye worm) hypothetical protein 0.0082 0.075 0.075
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.016 0.159 0.159
Brugia malayi ecdysone receptor 0.0039 0.0285 0.0285
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.0035 0.0035
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0042 0.0316 0.1231
Trichomonas vaginalis aldo/keto reductase, putative 0.0867 0.9188 1
Echinococcus granulosus thyroid hormone receptor alpha 0.0039 0.0285 0.0285
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0035 0.0035
Toxoplasma gondii aldo/keto reductase family oxidoreductase 0.0251 0.2569 0.2796
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0082 0.075 0.075
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0042 0.0316 0.0344
Plasmodium falciparum aldehyde reductase, putative 0.0251 0.2569 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0285 0.0285
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.016 0.159 0.159
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0082 0.075 0.075
Echinococcus granulosus histone acetyltransferase KAT2B 0.0042 0.0316 0.0316
Schistosoma mansoni sodium/chloride dependent transporter 0.0943 1 1
Onchocerca volvulus Protein ultraspiracle homolog 0.0082 0.075 0.0478
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0043 0.0335 0.0335
Schistosoma mansoni steroid hormone receptor ad4bp 0.0082 0.075 0.075
Brugia malayi nuclear receptor NHR-67 0.0039 0.0285 0.0285
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0082 0.075 0.075
Loa Loa (eye worm) hypothetical protein 0.016 0.159 0.159
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0867 0.9188 0.9188
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.016 0.159 0.159
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.016 0.159 0.159
Leishmania major prostaglandin f2-alpha synthase/D-arabinose dehydrogenase 0.0867 0.9188 1
Echinococcus multilocularis sodium and chloride dependent glycine 0.016 0.159 0.159
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.016 0.159 0.159
Brugia malayi Sodium:neurotransmitter symporter family protein 0.016 0.159 0.159
Loa Loa (eye worm) steroid hormone receptor 0.0082 0.075 0.075
Loa Loa (eye worm) hypothetical protein 0.0049 0.0392 0.0392
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0141 0.1387 0.1387
Leishmania major aldo/keto reductase, putative,aldo/keto reductase family-like protein 0.0251 0.2569 0.2796
Trichomonas vaginalis aldo-keto reductase, putative 0.0867 0.9188 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0346 0.0346
Brugia malayi Nuclear hormone receptor-like 1 0.0043 0.0335 0.0335
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.016 0.159 0.159
Loa Loa (eye worm) norepinephrine transporter 0.0943 1 1
Onchocerca volvulus 0.0943 1 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0346 0.0346
Loa Loa (eye worm) hypothetical protein 0.016 0.159 0.159
Trichomonas vaginalis aldo-keto reductase, putative 0.0251 0.2569 0.2796
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0867 0.9188 0.9188
Brugia malayi nuclear receptor NHR-88 0.0039 0.0285 0.0285
Echinococcus granulosus aldo keto reductase 0.0867 0.9188 0.9188
Trichomonas vaginalis conserved hypothetical protein 0.0251 0.2569 0.2796
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0867 0.9188 0.9188
Loa Loa (eye worm) nuclear hormone receptor 0.0039 0.0285 0.0285
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.016 0.159 0.173
Treponema pallidum sodium- and chloride- dependent transporter 0.0943 1 0.5
Brugia malayi Nuclear hormone receptor-like 1 0.0043 0.0335 0.0335
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0082 0.075 0.075
Schistosoma mansoni aldo-keto reductase 0.0867 0.9188 0.9188
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0867 0.9188 0.9188
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0115 0.1108 0.1108
Schistosoma mansoni hypothetical protein 0.0015 0.0035 0.0035
Echinococcus granulosus sodium and chloride dependent glycine 0.016 0.159 0.159
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.016 0.159 0.159
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0082 0.075 0.075
Plasmodium falciparum amino acid transporter, putative 0.016 0.159 0.6188
Loa Loa (eye worm) hypothetical protein 0.016 0.159 0.159
Schistosoma mansoni potassium channel beta 0.0251 0.2569 0.2569
Brugia malayi Nuclear hormone receptor-like 1 0.0082 0.075 0.075
Onchocerca volvulus 0.0867 0.9188 0.9164
Plasmodium vivax oxidoreductase, aldo/keto reductase domain containing protein 0.0251 0.2569 1
Schistosoma mansoni nuclear receptor nhr-48 0.0039 0.0285 0.0285
Loa Loa (eye worm) hypothetical protein 0.029 0.2987 0.2987
Echinococcus multilocularis muscleblind protein 1 0.029 0.2987 0.2987
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0867 0.9188 0.9188
Echinococcus multilocularis aldehyde reductase 0.0616 0.6489 0.6489
Echinococcus multilocularis serotonin transporter 0.0943 1 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0867 0.9188 0.9188
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0251 0.2569 0.2796
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0867 0.9188 0.9188
Loa Loa (eye worm) serotonin transporter b 0.0943 1 1
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0039 0.0285 0.0285
Loa Loa (eye worm) hypothetical protein 0.0082 0.075 0.075
Echinococcus multilocularis GPCR, family 2 0.0015 0.0035 0.0035
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0346 0.0346
Toxoplasma gondii aldo-keto reductase 0.0251 0.2569 0.2796
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0082 0.075 0.075
Loa Loa (eye worm) oxidoreductase 0.0867 0.9188 0.9188
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0082 0.075 0.075
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0082 0.075 0.075
Giardia lamblia Aldose reductase 0.0867 0.9188 1
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0115 0.1108 0.1108
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.016 0.159 0.159
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0082 0.075 0.075
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.016 0.159 0.159
Toxoplasma gondii hypothetical protein 0.016 0.159 0.173
Echinococcus granulosus aldo keto reductase 0.0867 0.9188 0.9188
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.016 0.159 0.173
Trypanosoma cruzi aldo-keto reductase 0.0867 0.9188 1
Brugia malayi acetyltransferase, GNAT family protein 0.0141 0.1387 0.1387
Loa Loa (eye worm) hypothetical protein 0.0039 0.0285 0.0285
Brugia malayi nuclear receptor RXR 0.0043 0.0335 0.0335
Echinococcus granulosus hypothetical protein 0.0867 0.9188 0.9188
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0082 0.075 0.075
Brugia malayi nuclear hormone receptor family member nhr-6 0.0039 0.0285 0.0285
Onchocerca volvulus 0.0251 0.2569 0.2351
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0082 0.075 0.075
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.0035 0.0035
Brugia malayi hypothetical protein 0.0039 0.0285 0.0285
Schistosoma mansoni nuclear hormone receptor 0.0039 0.0285 0.0285
Echinococcus granulosus uncharacterized sodium dependent transporter 0.016 0.159 0.159
Echinococcus multilocularis voltage gated potassium channel subunit 0.0251 0.2569 0.2569
Trichomonas vaginalis aldo/keto reductase, putative 0.0867 0.9188 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0867 0.9188 0.9188
Entamoeba histolytica alcohol dehydrogenase, putative 0.0251 0.2569 0.2796
Onchocerca volvulus 0.0867 0.9188 0.9164
Onchocerca volvulus 0.0867 0.9188 0.9164
Brugia malayi Nuclear hormone receptor E75 0.0039 0.0285 0.0285
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0141 0.1387 0.1387
Brugia malayi glutamate-cysteine ligase modifier subunit 0.0251 0.2569 0.2569
Schistosoma mansoni hypothetical protein 0.0033 0.0227 0.0227
Plasmodium vivax amine transporter, putative 0.016 0.159 0.6188
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0082 0.075 0.075
Schistosoma mansoni nuclear hormone receptor 0.0039 0.0285 0.0285
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0867 0.9188 1
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0227 0.0227
Trichomonas vaginalis pps1 dual specificty phosphatase, putative 0.0565 0.5938 0.6462
Brugia malayi photoreceptor-specific nuclear receptor 0.0082 0.075 0.075
Giardia lamblia Aldose reductase 0.0867 0.9188 1
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0039 0.0285 0.0285
Loa Loa (eye worm) hypothetical protein 0.0039 0.0285 0.0285
Loa Loa (eye worm) oxidoreductase 0.0867 0.9188 0.9188
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.0035 0.0035
Brugia malayi conserved hypotetical protein 0.0039 0.0285 0.0285
Plasmodium falciparum histone acetyltransferase GCN5 0.0038 0.0279 0.1086
Echinococcus multilocularis ecdysone induced protein 78C 0.0082 0.075 0.075
Onchocerca volvulus 0.0867 0.9188 0.9164
Trichomonas vaginalis aldo/keto reductase, putative 0.0867 0.9188 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0867 0.9188 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0285 0.0285
Brugia malayi Sodium:neurotransmitter symporter family protein 0.016 0.159 0.159
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0115 0.1108 0.1108
Echinococcus granulosus aldo keto reductase family 1, member B4 0.0251 0.2569 0.2569
Schistosoma mansoni aldo-keto reductase 0.0867 0.9188 0.9188
Toxoplasma gondii hypothetical protein 0.016 0.159 0.173
Loa Loa (eye worm) hypothetical protein 0.0033 0.0227 0.0227
Trichomonas vaginalis aldo-keto reductase, putative 0.0867 0.9188 1
Onchocerca volvulus Bile acid receptor homolog 0.0082 0.075 0.0478
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0035 0.0035
Trichomonas vaginalis aldo-keto reductase, putative 0.0867 0.9188 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0082 0.075 0.075
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0039 0.0285 0.0285
Echinococcus granulosus muscleblind protein 0.029 0.2987 0.2987
Brugia malayi hypothetical protein 0.0043 0.0335 0.0335
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0867 0.9188 0.9188
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0082 0.075 0.075
Brugia malayi Sodium:neurotransmitter symporter family protein 0.016 0.159 0.159
Brugia malayi nuclear receptor RXR 0.0039 0.0285 0.0285
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0867 0.9188 0.9188

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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