Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable purine nucleoside phosphorylase DeoD (inosine phosphorylase) (PNP) | 0.0117 | 0.1201 | 0.1259 |
Entamoeba histolytica | purine nucleoside phosphorylase, putative | 0.0117 | 0.1201 | 0.5 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.006 | 0.0221 | 0.0221 |
Treponema pallidum | uridine phosphorylase (udp) | 0.0117 | 0.1201 | 0.5 |
Plasmodium falciparum | purine nucleoside phosphorylase | 0.0117 | 0.1201 | 0.5 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0117 | 0.1201 | 0.1201 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0117 | 0.1201 | 0.1201 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0066 | 0.0327 | 0.0327 |
Schistosoma mansoni | hypothetical protein | 0.0173 | 0.216 | 0.216 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0122 | 0.1286 | 0.1286 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.006 | 0.0221 | 0.0221 |
Mycobacterium leprae | Probable purine nucleoside phosphorylase DeoD (INOSINE PHOSPHORYLASE) (PNP) | 0.0117 | 0.1201 | 0.5 |
Entamoeba histolytica | MTA/SAH nucleosidase, putative | 0.0117 | 0.1201 | 0.5 |
Trichomonas vaginalis | purine nucleoside phosphorylase, putative | 0.0117 | 0.1201 | 0.5 |
Schistosoma mansoni | uridine phosphorylase | 0.0117 | 0.1201 | 0.1201 |
Trichomonas vaginalis | purine nucleoside phosphorylase, putative | 0.0117 | 0.1201 | 0.5 |
Entamoeba histolytica | purine nucleoside phosphorylase, putative | 0.0117 | 0.1201 | 0.5 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0117 | 0.1201 | 0.1201 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0097 | 0.0849 | 0.0849 |
Echinococcus granulosus | geminin | 0.0173 | 0.216 | 0.216 |
Treponema pallidum | purine nucleoside phosphorylase (deoD) | 0.0117 | 0.1201 | 0.5 |
Loa Loa (eye worm) | S-methyl-5'-thioadenosine phosphorylase MTAP | 0.0633 | 1 | 1 |
Schistosoma mansoni | methylthioadenosine phosphorylase | 0.0117 | 0.1201 | 0.1201 |
Plasmodium vivax | purine nucleoside phosphorylase, putative | 0.0117 | 0.1201 | 0.5 |
Echinococcus granulosus | uridine phosphorylase 1 | 0.0117 | 0.1201 | 0.1201 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.0327 | 0.0327 |
Trichomonas vaginalis | purine nucleoside phosphorylase I, putative | 0.0117 | 0.1201 | 0.5 |
Toxoplasma gondii | phosphorylase family protein | 0.0117 | 0.1201 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0173 | 0.216 | 0.216 |
Onchocerca volvulus | Huntingtin homolog | 0.0125 | 0.134 | 0.2688 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0117 | 0.1201 | 0.1201 |
Mycobacterium tuberculosis | Probable 5'-methylthioadenosine phosphorylase Pnp (MTA phosphorylase) | 0.0516 | 0.8001 | 1 |
Mycobacterium leprae | probable uridine phosphorylase | 0.0117 | 0.1201 | 0.5 |
Mycobacterium ulcerans | purine nucleoside phosphorylase | 0.0117 | 0.1201 | 0.1002 |
Loa Loa (eye worm) | hypothetical protein | 0.0125 | 0.134 | 0.134 |
Toxoplasma gondii | Purine nucleoside phosphorylase | 0.0117 | 0.1201 | 1 |
Giardia lamblia | 5-methylthioadenosine nucleosidase, S-adenosylhomocysteine nucleosidase | 0.0117 | 0.1201 | 0.5 |
Toxoplasma gondii | phosphorylase family protein | 0.0117 | 0.1201 | 1 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0117 | 0.1201 | 0.1201 |
Loa Loa (eye worm) | uridine phosphorylase | 0.0117 | 0.1201 | 0.1201 |
Chlamydia trachomatis | AMP nucleosidase | 0.0117 | 0.1201 | 0.5 |
Brugia malayi | hypothetical protein | 0.0125 | 0.134 | 0.134 |
Mycobacterium ulcerans | bifunctional Mta/Sah nucleosidase Mtn | 0.0117 | 0.1201 | 0.1002 |
Onchocerca volvulus | Huntingtin homolog | 0.0125 | 0.134 | 0.2688 |
Entamoeba histolytica | purine nucleoside phosphorylase, putative | 0.0117 | 0.1201 | 0.5 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0117 | 0.1201 | 0.1201 |
Giardia lamblia | Purine nucleoside phosphorylase lateral transfer candidate | 0.0117 | 0.1201 | 0.5 |
Trypanosoma cruzi | methylthioadenosine phosphorylase, putative | 0.0633 | 1 | 1 |
Entamoeba histolytica | purine nucleoside phosphorylase, putative | 0.0117 | 0.1201 | 0.5 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0117 | 0.1201 | 0.1201 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0117 | 0.1201 | 0.1201 |
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.0849 | 0.0849 |
Loa Loa (eye worm) | hypothetical protein | 0.0125 | 0.134 | 0.134 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0117 | 0.1201 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0117 | 0.1201 | 0.5 |
Brugia malayi | hypothetical protein | 0.0148 | 0.172 | 0.172 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0097 | 0.0849 | 0.0849 |
Trypanosoma cruzi | methylthioadenosine phosphorylase, putative | 0.0633 | 1 | 1 |
Trichomonas vaginalis | purine nucleoside phosphorylase, putative | 0.0117 | 0.1201 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0066 | 0.0327 | 0.0327 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0117 | 0.1201 | 0.1259 |
Onchocerca volvulus | 0.0148 | 0.172 | 1 | |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0117 | 0.1201 | 0.1201 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.006 | 0.0221 | 0.0221 |
Brugia malayi | MH2 domain containing protein | 0.0122 | 0.1286 | 0.1286 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.006 | 0.0221 | 0.0221 |
Leishmania major | methylthioadenosine phosphorylase, putative | 0.0633 | 1 | 1 |
Leishmania major | nucleoside phosphorylase-like protein | 0.0117 | 0.1201 | 0.1002 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0117 | 0.1201 | 0.1259 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0117 | 0.1201 | 0.1201 |
Trichomonas vaginalis | purine nucleoside phosphorylase, putative | 0.0117 | 0.1201 | 0.5 |
Entamoeba histolytica | purine nucleoside phosphorylase, putative | 0.0117 | 0.1201 | 0.5 |
Mycobacterium tuberculosis | Probable bifunctional MTA/SAH nucleosidase Mtn: 5'-methylthioadenosine nucleosidase (methylthioadenosine methylthioribohydrolase | 0.0117 | 0.1201 | 0.1259 |
Trypanosoma brucei | methylthioadenosine phosphorylase, putative | 0.0633 | 1 | 1 |
Giardia lamblia | 5-methylthioadenosine nucleosidase, S-adenosylhomocysteine nucleosidase | 0.0117 | 0.1201 | 0.5 |
Schistosoma mansoni | methylthioadenosine phosphorylase | 0.0633 | 1 | 1 |
Schistosoma mansoni | methylthioadenosine phosphorylase | 0.0633 | 1 | 1 |
Schistosoma mansoni | purine nucleoside phosphorylase | 0.0117 | 0.1201 | 0.1201 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.172 | 0.172 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0117 | 0.1201 | 0.5 |
Echinococcus multilocularis | uridine phosphorylase 1 | 0.0117 | 0.1201 | 0.1201 |
Echinococcus multilocularis | geminin | 0.0173 | 0.216 | 0.216 |
Echinococcus granulosus | methylthioadenosine phosphorylase | 0.0633 | 1 | 1 |
Schistosoma mansoni | uridine phosphorylase | 0.0117 | 0.1201 | 0.1201 |
Giardia lamblia | UPL-1 | 0.0117 | 0.1201 | 0.5 |
Echinococcus multilocularis | methylthioadenosine phosphorylase | 0.0633 | 1 | 1 |
Trichomonas vaginalis | purine nucleoside phosphorylase, putative | 0.0117 | 0.1201 | 0.5 |
Schistosoma mansoni | purine nucleoside phosphorylase | 0.0117 | 0.1201 | 0.1201 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0097 | 0.0849 | 0.0849 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0117 | 0.1201 | 0.1201 |
Mycobacterium ulcerans | 5'-methylthioadenosine phosphorylase | 0.0633 | 1 | 1 |
Trichomonas vaginalis | purine nucleoside phosphorylase, putative | 0.0117 | 0.1201 | 0.5 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0117 | 0.1201 | 0.1201 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0122 | 0.1286 | 0.1286 |
Treponema pallidum | pfs protein (pfs) | 0.0117 | 0.1201 | 0.5 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0117 | 0.1201 | 0.1201 |
Brugia malayi | purine nucleoside phosphorylase I, inosine and guanosine-specific family protein | 0.0117 | 0.1201 | 0.1201 |
Brugia malayi | uridine phosphorylase family protein | 0.0117 | 0.1201 | 0.1201 |
Trichomonas vaginalis | purine nucleoside phosphorylase, putative | 0.0117 | 0.1201 | 0.5 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0117 | 0.1201 | 0.1201 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.