Detailed information for compound 560788

Basic information

Technical information
  • TDR Targets ID: 560788
  • Name: 2-[4-(cyclopropylmethyl)phenyl]acetic acid
  • MW: 190.238 | Formula: C12H14O2
  • H donors: 1 H acceptors: 2 LogP: 2.76 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)Cc1ccc(cc1)CC1CC1
  • InChi: 1S/C12H14O2/c13-12(14)8-11-5-3-10(4-6-11)7-9-1-2-9/h3-6,9H,1-2,7-8H2,(H,13,14)
  • InChiKey: IZUHDUVGUPGYPD-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[4-(cyclopropylmethyl)phenyl]ethanoic acid
  • (alpha-cyclopropyl-4-tolyl)acetic acid
  • 35981-69-2
  • (alpha-Cyclopropyl-p-tolyl)acetic acid
  • Benzeneacetic acid, 4-(cyclopropylmethyl)-

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0035 0.0097 0.1419
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0046 0.0171 0.249
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0101 0.0101
Echinococcus granulosus serine protein kinase ATM 0.0098 0.0499 0.0569
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0024 0.003 0.0269
Schistosoma mansoni hypothetical protein 0.0024 0.003 0.0034
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0024 0.003 0.0112
Loa Loa (eye worm) hypothetical protein 0.0054 0.0219 0.1978
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0024 0.003 0.0034
Schistosoma mansoni hypothetical protein 0.0035 0.0101 0.0116
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0124 0.0658 0.2334
Loa Loa (eye worm) hypothetical protein 0.0046 0.0171 0.1539
Brugia malayi AMP-binding enzyme family protein 0.0046 0.0171 0.1539
Entamoeba histolytica acyl-coA synthetase, putative 0.0046 0.0171 0.1539
Giardia lamblia Hypothetical protein 0.0024 0.003 0.0453
Trichomonas vaginalis PIKK family atypical protein kinase 0.0124 0.0658 1
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0098 0.0499 0.0569
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0024 0.003 0.0112
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0024 0.003 0.0453
Leishmania major hypothetical protein, conserved 0.0468 0.282 1
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0024 0.003 0.0112
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0051 0.0198 0.2885
Trichomonas vaginalis PIKK family atypical protein kinase 0.0124 0.0658 1
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0054 0.0219 0.025
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0024 0.003 0.0269
Trichomonas vaginalis PIKK family atypical protein kinase 0.0124 0.0658 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0046 0.0171 1
Echinococcus multilocularis microtubule associated protein 2 0.1412 0.8759 0.8759
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0024 0.003 0.0112
Leishmania major phosphatidylinositol kinase related protein, putative 0.0052 0.021 0.0743
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0024 0.003 0.1506
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.007 0.0319 0.0319
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0024 0.003 0.0269
Trichomonas vaginalis PIKK family atypical protein kinase 0.0124 0.0658 1
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0024 0.003 0.0269
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0198 0.1128 0.1288
Trichomonas vaginalis PIKK family atypical protein kinase 0.007 0.0319 0.4846
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0024 0.003 0.1506
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0098 0.0499 0.1868
Echinococcus granulosus Spectrin alpha actinin 0.0034 0.0097 0.0111
Loa Loa (eye worm) phosphatidylinositol 3 0.0024 0.003 0.0269
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.0185 0.1664
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0024 0.003 0.0269
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0024 0.003 0.0034
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0024 0.003 0.0269
Loa Loa (eye worm) phosphatidylinositol 3 0.0024 0.003 0.0269
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0124 0.0658 0.5934
Toxoplasma gondii thioredoxin reductase 0.0051 0.0198 0.3005
Trichomonas vaginalis PIKK family atypical protein kinase 0.0124 0.0658 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.007 0.0319 0.4846
Echinococcus multilocularis Niemann Pick C1 protein 0.0195 0.1109 0.1109
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.0185 0.1664
Giardia lamblia Phosphatidylinositol 4-kinase 0.0024 0.003 0.0453
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0115 0.0605 0.8767
Trichomonas vaginalis PIKK family atypical protein kinase 0.0124 0.0658 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.007 0.0319 0.4846
Entamoeba histolytica hypothetical protein 0.0024 0.003 0.0269
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0024 0.003 0.0453
Mycobacterium ulcerans acyl-CoA synthetase 0.0046 0.0171 1
Loa Loa (eye worm) hypothetical protein 0.0103 0.0526 0.4744
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0124 0.0658 0.2464
Echinococcus granulosus expressed conserved protein 0.0184 0.1034 0.1181
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0024 0.003 0.0453
Plasmodium falciparum acyl-CoA synthetase 0.0035 0.0097 0.4918
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0024 0.003 0.1506
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0024 0.003 0.0453
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0101 0.0116
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0 0.5
Trypanosoma cruzi hypothetical protein, conserved 0.0444 0.267 1
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0024 0.003 0.0034
Echinococcus granulosus Niemann Pick C1 protein 0.0195 0.1109 0.1266
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0024 0.003 0.1506
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.0169 0.2571
Loa Loa (eye worm) phosphatidylinositol kinase 0.0024 0.003 0.0269
Brugia malayi glutathione reductase 0.0051 0.0198 0.1783
Loa Loa (eye worm) hypothetical protein 0.0078 0.0369 0.3327
Schistosoma mansoni hypothetical protein 0.0081 0.0388 0.0443
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0024 0.003 0.1506
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0159 0.0159
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0128 0.0685 1
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0024 0.003 0.0453
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0024 0.003 0.003
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0024 0.003 0.0453
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0124 0.0658 1
Entamoeba histolytica hypothetical protein 0.0035 0.0101 0.0914
Echinococcus multilocularis expressed conserved protein 0.0184 0.1034 0.1034
Brugia malayi AMP-binding enzyme family protein 0.0046 0.0171 0.1539
Trichomonas vaginalis conserved hypothetical protein 0.0078 0.0369 0.5607
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0024 0.003 0.0453
Echinococcus multilocularis protein dispatched 1 0.0096 0.0482 0.0482
Echinococcus multilocularis 0.0024 0.003 0.003
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0088 0.0796
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0159 0.0159
Loa Loa (eye worm) hypothetical protein 0.0046 0.0171 0.1539
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0024 0.003 0.0034
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0024 0.003 0.0453
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0128 0.0685 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0159 0.0182
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0085 0.1246
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0195 0.1109 1
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0124 0.0658 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0124 0.0658 1
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0098 0.0499 0.7579
Trichomonas vaginalis PIKK family atypical protein kinase 0.0124 0.0658 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0035 0.0097 0.5697
Echinococcus multilocularis sterol regulatory element binding protein 0.0084 0.0407 0.0407
Echinococcus multilocularis serine protein kinase ATM 0.0098 0.0499 0.0499
Trypanosoma cruzi kinetoplast DNA-associated protein, putative 0.0034 0.0097 0.0363
Echinococcus granulosus serine:threonine protein kinase SMG1 0.007 0.0319 0.0364
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0124 0.0658 0.0751
Mycobacterium ulcerans acyl-CoA synthetase 0.0046 0.0171 1
Brugia malayi Growth-Arrest-Specific Protein 2 Domain containing protein 0.0034 0.0097 0.0875
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.003 0.0453
Entamoeba histolytica hypothetical protein 0.0024 0.003 0.0269
Trichomonas vaginalis conserved hypothetical protein 0.0084 0.0407 0.6192
Toxoplasma gondii target of rapamycin (TOR), putative 0.0124 0.0658 1
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0115 0.0605 0.8821
Schistosoma mansoni cellular tumor antigen P53 0.0108 0.0562 0.0642
Loa Loa (eye worm) glutathione reductase 0.0051 0.0198 0.1783
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0024 0.003 0.0453
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0024 0.003 0.0034
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0124 0.0658 0.0658
Loa Loa (eye worm) phosphatidylinositol 3 0.0024 0.003 0.0269
Loa Loa (eye worm) hypothetical protein 0.0033 0.0088 0.0796
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0024 0.003 0.1506
Loa Loa (eye worm) hypothetical protein 0.0035 0.0097 0.0877
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0078 0.0369 0.5607
Echinococcus multilocularis thioredoxin glutathione reductase 0.0051 0.0198 0.0198
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0024 0.003 0.0453
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0124 0.0658 0.2464
Brugia malayi VAB-10A protein 0.0034 0.0097 0.0875
Trichomonas vaginalis PIKK family atypical protein kinase 0.0124 0.0658 1
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0124 0.0658 0.5934
Entamoeba histolytica acyl-CoA synthetase, putative 0.0046 0.0171 0.1539
Trichomonas vaginalis PIKK family atypical protein kinase 0.0124 0.0658 1
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0024 0.003 0.0034
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0124 0.0658 1
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.1275 0.79 0.79
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0085 0.1246
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0124 0.0658 0.0658
Loa Loa (eye worm) hypothetical protein 0.0108 0.0562 0.507
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0024 0.003 0.0269
Leishmania major phosphatidylinositol 3-kinase, putative 0.0024 0.003 0.0106
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0046 0.0171 0.249
Entamoeba histolytica hypothetical protein 0.0035 0.0101 0.0914
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0024 0.003 0.0112
Loa Loa (eye worm) phosphatidylinositol 3 0.0024 0.003 0.0269
Trichomonas vaginalis PIKK family atypical protein kinase 0.0124 0.0658 1
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0024 0.003 0.0269
Trichomonas vaginalis PIKK family atypical protein kinase 0.0124 0.0658 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0097 0.0877
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0024 0.003 0.0453
Brugia malayi CHE-14 protein 0.0084 0.0407 0.3674
Loa Loa (eye worm) hypothetical protein 0.0024 0.003 0.0269
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0124 0.0658 0.2334
Entamoeba histolytica hypothetical protein 0.0098 0.0499 0.4497
Onchocerca volvulus 0.0108 0.0562 1
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0024 0.003 0.0112
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0124 0.0658 0.2334
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0024 0.003 0.1506
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0024 0.003 0.0034
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0024 0.003 0.0453
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.007 0.0319 0.2875
Loa Loa (eye worm) hypothetical protein 0.0195 0.1109 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0046 0.0171 0.0605
Loa Loa (eye worm) spectraplakin 0.0034 0.0097 0.0875
Echinococcus granulosus thioredoxin glutathione reductase 0.0051 0.0198 0.0226
Schistosoma mansoni hypothetical protein 0.0054 0.0219 0.025
Echinococcus multilocularis tumor protein p63 0.0741 0.454 0.454
Trichomonas vaginalis PIKK family atypical protein kinase 0.007 0.0319 0.4846
Trichomonas vaginalis PIKK family atypical protein kinase 0.0124 0.0658 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.007 0.0319 0.4846
Schistosoma mansoni patched 1 0.0084 0.0407 0.0465
Loa Loa (eye worm) hypothetical protein 0.0048 0.0185 0.1664
Loa Loa (eye worm) hypothetical protein 0.0024 0.003 0.0269
Trypanosoma brucei trypanothione reductase 0.0051 0.0198 0.3005
Toxoplasma gondii FATC domain-containing protein 0.0098 0.0499 0.7579
Mycobacterium tuberculosis Probable oxidoreductase 0.0128 0.0685 1
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0124 0.0658 0.0751
Trypanosoma cruzi target of rapamycin kinase 3 0.0124 0.0658 0.2464
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0024 0.003 0.0453
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0 0.5
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0052 0.021 0.0785
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0115 0.0605 0.8821
Echinococcus granulosus muscleblind protein 0.0146 0.0799 0.0912
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.0159 0.1438
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0024 0.003 0.0034
Schistosoma mansoni hypothetical protein 0.0081 0.0388 0.0443
Entamoeba histolytica hypothetical protein 0.0035 0.0101 0.0914
Trichomonas vaginalis PIKK family atypical protein kinase 0.0078 0.0369 0.5607
Loa Loa (eye worm) phosphatidylinositol 3 0.0024 0.003 0.0269
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0124 0.0658 0.2464
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0024 0.003 0.0034
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0098 0.0499 0.4497
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0024 0.003 0.0034
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.007 0.0319 0.1194
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0115 0.0605 0.8821
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0124 0.0658 0.0751
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0124 0.0658 0.5934
Trichomonas vaginalis PIKK family atypical protein kinase 0.0124 0.0658 1
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0024 0.003 0.0453
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0024 0.003 0.0034
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0046 0.0171 1
Entamoeba histolytica hypothetical protein 0.0035 0.0101 0.0914
Trichomonas vaginalis PIKK family atypical protein kinase 0.0124 0.0658 1
Echinococcus multilocularis muscleblind protein 1 0.0146 0.0799 0.0799
Leishmania major 4-coumarate:coa ligase-like protein 0.0046 0.0171 0.0605
Entamoeba histolytica hypothetical protein 0.0024 0.003 0.0269
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0024 0.003 0.0453
Trichomonas vaginalis PIKK family atypical protein kinase 0.0124 0.0658 1
Mycobacterium ulcerans hypothetical protein 0.0046 0.0171 1
Leishmania major phosphatidylinositol 3-kinase, putative 0.0124 0.0658 0.2334
Mycobacterium tuberculosis Probable reductase 0.0115 0.0605 0.8821
Plasmodium vivax hypothetical protein 0.0024 0.003 0.1506
Echinococcus multilocularis Spectrin alpha actinin 0.0034 0.0097 0.0097
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0084 0.0407 0.3674
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0024 0.003 0.0269
Plasmodium vivax glutathione reductase, putative 0.0051 0.0198 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.003 0.0453
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0024 0.003 0.0453
Loa Loa (eye worm) thioredoxin reductase 0.0051 0.0198 0.1783
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0024 0.003 0.0034
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0024 0.003 0.0112
Schistosoma mansoni hypothetical protein 0.0034 0.0097 0.0111
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0024 0.003 0.0453
Loa Loa (eye worm) hypothetical protein 0.0046 0.0171 0.1539
Loa Loa (eye worm) phosphatidylinositol 3 0.0124 0.0658 0.5934
Trichomonas vaginalis PIKK family atypical protein kinase 0.0124 0.0658 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0159 0.0182
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0024 0.003 0.003
Trypanosoma cruzi trypanothione reductase, putative 0.0051 0.0198 0.0741
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0128 0.0685 1
Plasmodium falciparum glutathione reductase 0.0051 0.0198 1
Schistosoma mansoni fkbp-rapamycin associated protein 0.007 0.0319 0.0364
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0024 0.003 0.0453
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0046 0.0171 0.2149
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0024 0.003 0.0269
Echinococcus granulosus sterol regulatory element binding protein 0.0084 0.0407 0.0465
Loa Loa (eye worm) hypothetical protein 0.0035 0.0097 0.0877
Schistosoma mansoni hypothetical protein 0.0033 0.0088 0.0101
Entamoeba histolytica hypothetical protein 0.0024 0.003 0.0269
Trichomonas vaginalis PIKK family atypical protein kinase 0.0098 0.0499 0.7579
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0159 0.0182
Leishmania major phosphatidylinositol kinase, putative 0.0024 0.003 0.0106
Plasmodium vivax hypothetical protein, conserved 0.0024 0.003 0.1506
Echinococcus granulosus Niemann Pick C1 protein 0.0279 0.1636 0.1868
Trichomonas vaginalis PIKK family atypical protein kinase 0.0124 0.0658 1
Schistosoma mansoni hypothetical protein 0.0034 0.0097 0.0111
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0046 0.0171 1
Echinococcus granulosus Protein patched homolog 1 0.0084 0.0407 0.0465
Onchocerca volvulus 0.0046 0.0171 0.2647
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0124 0.0658 0.2334
Trichomonas vaginalis PIKK family atypical protein kinase 0.0124 0.0658 1
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0024 0.003 0.0453
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0024 0.003 0.003
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0046 0.0171 0.2149
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0115 0.0605 0.8821
Echinococcus multilocularis Niemann Pick C1 protein 0.0279 0.1636 0.1636
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0024 0.003 0.0034
Loa Loa (eye worm) hypothetical protein 0.0034 0.0097 0.0875
Leishmania major 4-coumarate:coa ligase-like protein 0.0046 0.0171 0.0605
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0124 0.0658 0.0751
Trichomonas vaginalis PIKK family atypical protein kinase 0.0124 0.0658 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.0159 0.1438
Brugia malayi hypothetical protein 0.0035 0.0101 0.0914
Mycobacterium tuberculosis Probable dehydrogenase 0.0115 0.0605 0.8821
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0124 0.0658 1
Echinococcus multilocularis muscleblind protein 0.0146 0.0799 0.0799
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0046 0.0171 1
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0124 0.0658 1
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0046 0.0171 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.007 0.0319 0.4846
Echinococcus multilocularis protein patched 0.0084 0.0407 0.0407
Plasmodium vivax acyl-CoA synthetase, putative 0.0035 0.0097 0.4918
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0024 0.003 0.0453
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0159 0.0182
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0024 0.003 0.0453
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0024 0.003 0.003
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0101 0.0116
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0169 0.2571
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0024 0.003 0.0269
Loa Loa (eye worm) hypothetical protein 0.0146 0.0799 0.7203
Brugia malayi FAT domain containing protein 0.0054 0.0219 0.1978
Leishmania major phosphatidylinositol 4-kinase, putative 0.0024 0.003 0.0106
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0024 0.003 0.0453
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0085 0.1246
Schistosoma mansoni microtubule-associated protein tau 0.1412 0.8759 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0097 0.0877
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0024 0.003 0.0453
Loa Loa (eye worm) hypothetical protein 0.0084 0.0407 0.3674
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.003 0.0453
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0075 0.0349 0.1307
Brugia malayi Niemann-Pick C1 protein precursor 0.0195 0.1109 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.007 0.0319 0.4846
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0035 0.0097 0.5
Loa Loa (eye worm) phosphatidylinositol 3 0.0124 0.0658 0.5934
Trichomonas vaginalis PIKK family atypical protein kinase 0.0124 0.0658 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0124 0.0658 1
Leishmania major trypanothione reductase 0.0051 0.0198 0.0701
Loa Loa (eye worm) hypothetical protein 0.0146 0.0799 0.7203
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0024 0.003 0.003
Trichomonas vaginalis PIKK family atypical protein kinase 0.0124 0.0658 1
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0024 0.003 0.0112
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0054 0.0219 0.0219
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0085 0.1246
Trichomonas vaginalis PIKK family atypical protein kinase 0.0124 0.0658 1
Schistosoma mansoni hypothetical protein 0.0081 0.0388 0.0443
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.0219 0.3333
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0159 0.0182
Trichomonas vaginalis PIKK family atypical protein kinase 0.0124 0.0658 1
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0024 0.003 0.0034
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0024 0.003 0.0106
Brugia malayi Thioredoxin reductase 0.0051 0.0198 0.1783
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0024 0.003 0.0269
Loa Loa (eye worm) hypothetical protein 0.0035 0.0097 0.0877
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.0185 0.1664
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0024 0.003 0.0269
Trichomonas vaginalis PIKK family atypical protein kinase 0.0124 0.0658 1
Echinococcus granulosus tumor protein p63 0.0741 0.454 0.5183
Echinococcus multilocularis Zinc finger, PHD finger 0.0024 0.003 0.003
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0124 0.0658 0.5934
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0078 0.0369 0.5607
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0024 0.003 0.0269
Echinococcus granulosus microtubule associated protein 2 0.1412 0.8759 1
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0024 0.003 0.0453
Leishmania major hypothetical protein, unknown function 0.0024 0.003 0.0106
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0024 0.003 0.0269
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0024 0.003 0.0269
Schistosoma mansoni hypothetical protein 0.0081 0.0388 0.0443
Loa Loa (eye worm) hypothetical protein 0.007 0.0319 0.2875
Trichomonas vaginalis PIKK family atypical protein kinase 0.0124 0.0658 1
Brugia malayi Muscleblind-like protein 0.0146 0.0799 0.7203
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0024 0.003 0.0453
Entamoeba histolytica protein kinase rad3, putative 0.007 0.0319 0.2875
Plasmodium vivax thioredoxin reductase, putative 0.0051 0.0198 1
Loa Loa (eye worm) hypothetical protein 0.0075 0.0349 0.3148
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.1275 0.79 0.9019
Brugia malayi AMP-binding enzyme family protein 0.0046 0.0171 0.1539
Plasmodium falciparum thioredoxin reductase 0.0051 0.0198 1
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0124 0.0658 0.2464
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.007 0.0319 0.2875
Giardia lamblia GTOR 0.0124 0.0658 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0124 0.0658 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0024 0.003 0.0435
Trichomonas vaginalis PIKK family atypical protein kinase 0.0124 0.0658 1
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0024 0.003 0.0112
Entamoeba histolytica acyl-CoA synthetase, putative 0.0046 0.0171 0.1539

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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