Detailed information for compound 562257

Basic information

Technical information
  • TDR Targets ID: 562257
  • Name: [(2R,3S,4R,5R)-3,4-dihydroxy-5-imidazo[2,1-f] purin-3-yl-tetrahydrofuran-2-yl]methyl phosph ono hydrogen phosphate
  • MW: 451.223 | Formula: C12H15N5O10P2
  • H donors: 5 H acceptors: 10 LogP: -3.39 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O[C@@H]1[C@H](O)[C@H](O[C@H]1n1cnc2c1ncn1c2ncc1)COP(=O)(OP(=O)(O)O)O
  • InChi: 1S/C12H15N5O10P2/c18-8-6(3-25-29(23,24)27-28(20,21)22)26-12(9(8)19)17-5-14-7-10-13-1-2-16(10)4-15-11(7)17/h1-2,4-6,8-9,12,18-19H,3H2,(H,23,24)(H2,20,21,22)/t6-,8-,9-,12-/m1/s1
  • InChiKey: OWCTWNCXGDVJGX-WOUKDFQISA-N  


Substructure search Similarity search

Network

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Synonyms

  • [(2R,3S,4R,5R)-3,4-dihydroxy-5-(3-imidazo[2,1-f]purinyl)-2-tetrahydrofuranyl]methyl phosphono hydrogen phosphate
  • [(2R,3S,4R,5R)-3,4-dihydroxy-5-imidazo[2,1-f]purin-3-yl-oxolan-2-yl]methyl phosphono hydrogen phosphate
  • [(2R,3S,4R,5R)-3,4-dihydroxy-5-imidazo[2,1-f]purin-3-yloxolan-2-yl]methyl phosphono hydrogen phosphate
  • 1,N(6)-ethenoadenosine diphosphate
  • 38806-39-2
  • 1,N(6)-Etheno-ADP
  • 3H-Imidazo(2,1-i)purine, 3-(5-O-(hydroxy(phosphonooxy)phosphinyl)-beta-D-ribofuranosyl)-
  • Epsilon-ADP
  • Ethenoadenosine diphosphate
  • NEADP

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni jumonji domain containing protein 0.0057 0.0517 0.0517
Echinococcus multilocularis ceramide kinase 0.0037 0.0305 0.0305
Trypanosoma cruzi diacylglycerol kinase-like protein, putative 0.0037 0.0305 0.0784
Echinococcus granulosus JmjC domain containing protein 4 0.0015 0.0074 0.0074
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0164 0.0164
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.0305 0.0784
Echinococcus multilocularis lysine specific demethylase 5A 0.0057 0.0517 0.0517
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0041 0.035 0.0937
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0057 0.0517 0.0517
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0164 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0297 0.0297
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0015 0.0074 0.0074
Mycobacterium ulcerans hypothetical protein 0.0154 0.1553 0.1553
Loa Loa (eye worm) hypothetical protein 0.0053 0.0473 0.0469
Mycobacterium tuberculosis Conserved protein 0.0948 1 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0056 0.0508 0.0508
Brugia malayi hypothetical protein 0.0037 0.0305 0.1307
Brugia malayi follicle stimulating hormone receptor 0.0226 0.2317 1
Brugia malayi jmjC domain containing protein 0.0015 0.0074 0.0306
Trypanosoma brucei Diacylglycerol kinase catalytic domain containing protein, putative 0.0037 0.0305 0.0784
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0052 0.0468 0.0464
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0097 0.0945 0.0945
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0056 0.0508 0.0508
Brugia malayi jmjC domain containing protein 0.0057 0.0517 0.2223
Schistosoma mansoni protein phosphatase 2C 0.0015 0.0074 0.0074
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0118 0.0118
Schistosoma mansoni jumonji/arid domain-containing protein 0.0058 0.0534 0.0534
Echinococcus multilocularis jumonji domain containing 1A 0.0015 0.0074 0.0074
Schistosoma mansoni sex comb on midleg homolog 0.0053 0.0473 0.0473
Echinococcus multilocularis sphingosine kinase 1 0.0948 1 1
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0118 0.1927
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0118 0.0151
Plasmodium vivax diacylglycerol kinase, putative 0.0037 0.0305 1
Schistosoma mansoni cpg binding protein 0.0029 0.0226 0.0226
Echinococcus granulosus phd:f box containing protein 0.0015 0.0074 0.0074
Loa Loa (eye worm) hypothetical protein 0.0015 0.0074 0.007
Toxoplasma gondii diacylglycerol kinase accessory domain (presumed) domain-containing protein 0.0037 0.0305 0.5794
Loa Loa (eye worm) diacylglycerol kinase 2 0.0037 0.0305 0.0301
Echinococcus multilocularis geminin 0.0169 0.1706 0.1706
Echinococcus granulosus Diacylglycerol kinase theta 0.0037 0.0305 0.0305
Brugia malayi hypothetical protein 0.0036 0.0297 0.127
Trypanosoma cruzi Diacylglycerol kinase catalytic domain containing protein, putative 0.0037 0.0305 0.0784
Onchocerca volvulus 0.0037 0.0305 0.6245
Schistosoma mansoni myelin transcription factor 1 myt1 0.006 0.0551 0.0551
Echinococcus granulosus Diacylglycerol kinase zeta 0.0037 0.0305 0.0305
Entamoeba histolytica diacylglycerol kinase, putative 0.0037 0.0305 0.0189
Schistosoma mansoni jumonji domain containing protein 0.0015 0.0074 0.0074
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.006 0.0551 0.2368
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0118 1
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.01 0.01
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0164 0.0164
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0017 0.0091 0.0091
Loa Loa (eye worm) hypothetical protein 0.0024 0.0164 0.0159
Echinococcus multilocularis histone acetyltransferase MYST2 0.006 0.0551 0.0551
Brugia malayi Eye-specific diacylglycerol kinase 0.0037 0.0305 0.1307
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.009 0.009
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0118 0.0151
Loa Loa (eye worm) jmjC domain-containing protein 0.0015 0.0074 0.007
Echinococcus granulosus acylglycerol kinase mitochondrial 0.0037 0.0305 0.0305
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0097 0.0945 0.0945
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0293 0.3027 1
Trypanosoma cruzi Sphingosine kinase 0.0037 0.0305 0.0784
Trichomonas vaginalis bmru protein, putative 0.0037 0.0305 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0118 0.0118
Loa Loa (eye worm) MBCTL1 0.006 0.0551 0.0547
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0041 0.035 0.0937
Echinococcus granulosus geminin 0.0169 0.1706 0.1706
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0118 0.5
Loa Loa (eye worm) hypothetical protein 0.0024 0.0164 0.0159
Echinococcus granulosus jumonji domain containing 1A 0.0015 0.0074 0.0074
Onchocerca volvulus Ceramide kinase 1 homolog 0.0037 0.0305 0.6245
Plasmodium vivax diacylglycerol kinase, putative 0.0037 0.0305 1
Entamoeba histolytica diacylglycerol kinase, putative 0.0037 0.0305 0.0189
Loa Loa (eye worm) hypothetical protein 0.0015 0.0074 0.007
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0164 0.0164
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.035 0.0937
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0164 0.0164
Toxoplasma gondii diacylglycerol kinase catalytic domain-containing protein 0.0037 0.0305 0.5794
Schistosoma mansoni diacylglycerol kinase theta 0.0037 0.0305 0.0305
Schistosoma mansoni hypothetical protein 0.0169 0.1706 0.1706
Mycobacterium ulcerans diacylglycerol kinase 0.0037 0.0305 0.0305
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.006 0.0551 0.0551
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0118 0.0151
Toxoplasma gondii hypothetical protein 0.0047 0.0415 0.853
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0164 0.0304
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0056 0.0508 0.0508
Leishmania major sphingosine kinase A, B, putative 0.0037 0.0305 0.0784
Mycobacterium ulcerans hypothetical protein 0.0948 1 1
Brugia malayi Ceramide kinase 0.0037 0.0305 0.1307
Echinococcus multilocularis cpg binding protein 0.0029 0.0226 0.0226
Echinococcus granulosus histone acetyltransferase MYST2 0.006 0.0551 0.0551
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0138 0.1386 0.4445
Entamoeba histolytica diacylglycerol kinase, putative 0.0037 0.0305 0.0189
Brugia malayi mbt repeat family protein 0.0053 0.0473 0.2032
Schistosoma mansoni hypothetical protein 0.0036 0.0297 0.0297
Onchocerca volvulus 0.0053 0.0473 1
Onchocerca volvulus 0.0024 0.0164 0.3069
Brugia malayi CXXC zinc finger family protein 0.0028 0.0209 0.0889
Schistosoma mansoni proteasome subunit alpha 6 (T01 family) 0.0037 0.0305 0.0305
Echinococcus multilocularis lysine specific demethylase 6a 0.0015 0.0074 0.0074
Trichomonas vaginalis diacylglycerol kinase, putative 0.0037 0.0305 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0297 0.0297
Schistosoma mansoni hypothetical protein 0.0169 0.1706 0.1706
Trypanosoma cruzi diacylglycerol kinase, putative 0.0037 0.0305 0.0784
Brugia malayi jmjC domain containing protein 0.0058 0.0534 0.2296
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0164 0.0694
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.009 0.009
Brugia malayi diacylglycerol kinase 0.0037 0.0305 0.1307
Entamoeba histolytica hypothetical protein 0.0036 0.0297 0.0181
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0226 0.2317 0.2314
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0056 0.0508 0.0508
Leishmania major diacylglycerol kinase, putative 0.0037 0.0305 0.0784
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0305 0.0784
Schistosoma mansoni sphingoid long chain base kinase 0.0948 1 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0004 0.0004
Mycobacterium tuberculosis Diacylglycerol kinase 0.0037 0.0305 0.0305
Loa Loa (eye worm) hypothetical protein 0.0948 1 1
Entamoeba histolytica hypothetical protein, conserved 0.0948 1 1
Loa Loa (eye worm) mbt repeat family protein 0.0053 0.0473 0.0469
Brugia malayi jmjC domain containing protein 0.0015 0.0074 0.0306
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0057 0.0517 0.0517
Trypanosoma brucei Sphingosine kinase 0.0037 0.0305 0.0784
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0305 1
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0118 0.0151
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0056 0.0508 0.2183
Loa Loa (eye worm) hypothetical protein 0.0037 0.0305 0.0301
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0118 0.3878
Echinococcus multilocularis phd:f box containing protein 0.0015 0.0074 0.0074
Loa Loa (eye worm) jmjC domain-containing protein 0.0015 0.0074 0.007
Entamoeba histolytica hypothetical protein 0.0036 0.0297 0.0181
Schistosoma mansoni cpg binding protein 0.0028 0.0209 0.0209
Echinococcus granulosus polycomb protein SCMH1 0.0053 0.0473 0.0473
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0097 0.0945 0.0945
Trichomonas vaginalis diacylglycerol kinase, zeta, iota, putative 0.0037 0.0305 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.01 0.0096
Loa Loa (eye worm) hypothetical protein 0.006 0.0551 0.0547
Schistosoma mansoni ap endonuclease 0.0019 0.0118 0.0118
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0053 0.0473 0.0473
Plasmodium falciparum diacylglycerol kinase, putative 0.0037 0.0305 1
Onchocerca volvulus 0.0028 0.0209 0.4081
Echinococcus granulosus lysine specific demethylase 6a 0.0015 0.0074 0.0074
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.009 0.009
Schistosoma mansoni cpg binding protein 0.0029 0.0226 0.0226
Plasmodium falciparum diacylglycerol kinase, putative 0.0037 0.0305 1
Echinococcus multilocularis JmjC domain containing protein 4 0.0015 0.0074 0.0074
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0056 0.0508 0.1471
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0293 0.3027 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0015 0.0074 0.007
Trichomonas vaginalis diacylglycerol kinase, putative 0.0037 0.0305 1
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0004 0.0004
Schistosoma mansoni diacylglycerol kinase theta 0.0037 0.0305 0.0305
Schistosoma mansoni sphingosine kinase A B 0.0948 1 1
Entamoeba histolytica hypothetical protein 0.0036 0.0297 0.0181
Toxoplasma gondii diacylglycerol kinase, putative 0.0037 0.0305 0.5794
Echinococcus multilocularis SAM and MBT domain containing protein 0.0053 0.0473 0.0473
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0056 0.0508 0.0508
Echinococcus multilocularis Diacylglycerol kinase theta 0.0037 0.0305 0.0305
Leishmania major hypothetical protein, conserved 0.0037 0.0305 0.0784
Trichomonas vaginalis diacylglycerol kinase, zeta, iota, putative 0.0037 0.0305 1
Echinococcus granulosus lysine specific demethylase 5A 0.0058 0.0534 0.0534
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0164 0.0304
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.009 0.009
Loa Loa (eye worm) hypothetical protein 0.0018 0.01 0.0096
Mycobacterium tuberculosis Conserved hypothetical protein 0.0154 0.1553 0.1553
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0164 0.0694
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.006 0.0551 0.0551
Trichomonas vaginalis diacylglycerol kinase, epsilon, putative 0.0037 0.0305 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0164 0.0046
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0209 0.0205
Echinococcus granulosus dnaJ subfamily B 0.0396 0.413 0.413
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0164 0.0164
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0059 0.0541 0.0541
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.035 0.0937
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0056 0.0508 0.0508
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.005 0.0446 0.1261
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0118 0.0118
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0164 0.0046
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0164 0.0304
Toxoplasma gondii histone lysine methyltransferase SET1 0.0053 0.0474 1
Schistosoma mansoni hypothetical protein 0.0037 0.0305 0.0305
Trichomonas vaginalis bmru protein, putative 0.0037 0.0305 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0097 0.0945 0.0945
Loa Loa (eye worm) ceramide kinase 0.0037 0.0305 0.0301
Trypanosoma cruzi Sphingosine kinase 0.0037 0.0305 0.0784
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0018 0.01 0.01
Brugia malayi Diacylglycerol kinase protein 2 0.0037 0.0305 0.1307
Schistosoma mansoni ap endonuclease 0.0019 0.0118 0.0118
Trichomonas vaginalis sphingosine kinase, putative 0.0037 0.0305 1
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0118 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0074 0.007
Schistosoma mansoni diacylglycerol kinase zeta iota 0.0037 0.0305 0.0305
Loa Loa (eye worm) hypothetical protein 0.0018 0.01 0.0096
Loa Loa (eye worm) hypothetical protein 0.0018 0.01 0.0096
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0053 0.0473 1
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.01 0.1133
Echinococcus multilocularis acylglycerol kinase, mitochondrial 0.0037 0.0305 0.0305
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0118 0.1927
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0097 0.0945 0.0945
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0097 0.0945 0.0945
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0164 0.0164
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.01 0.1133
Echinococcus multilocularis Diacylglycerol kinase zeta 0.0037 0.0305 0.0305
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0212 0.2164 0.2164
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0118 0.0118
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0118 0.3878
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0138 0.1386 0.4445
Leishmania major mitochondrial DNA polymerase beta 0.0293 0.3027 1
Echinococcus multilocularis dnaJ subfamily B 0.0396 0.413 0.413
Trypanosoma brucei diacylglycerol kinase, putative 0.0037 0.0305 0.0784
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0017 0.0091 0.0091
Entamoeba histolytica hypothetical protein 0.0036 0.0297 0.0181
Leishmania major hypothetical protein, conserved 0.0037 0.0305 0.0784
Mycobacterium ulcerans hypothetical protein 0.0024 0.0164 0.0164
Brugia malayi mbt repeat family protein 0.0053 0.0473 0.2032
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0164 0.0046
Loa Loa (eye worm) eye-specific diacylglycerol kinase 0.0037 0.0305 0.0301
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0164 0.0164
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0164 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0305 0.0301
Loa Loa (eye worm) hypothetical protein 0.0018 0.01 0.0096
Echinococcus granulosus SAM and MBT domain containing protein 0.0053 0.0473 0.0473
Schistosoma mansoni hypothetical protein 0.0396 0.413 0.413
Schistosoma mansoni sex comb on midleg homolog 0.0053 0.0473 0.0473
Schistosoma mansoni hypothetical protein 0.0324 0.3363 0.3363
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0212 0.2164 0.2164
Schistosoma mansoni phd/f-box containing protein 0.0015 0.0074 0.0074
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0018 0.01 0.5
Brugia malayi jmjC domain containing protein 0.0015 0.0074 0.0306
Toxoplasma gondii exonuclease III APE 0.0019 0.0118 0.1117
Schistosoma mansoni phosphatidylserine receptor 0.0015 0.0074 0.0074
Trichomonas vaginalis sphingosine kinase, putative 0.0037 0.0305 1
Brugia malayi jmjC domain containing protein 0.0015 0.0074 0.0306
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0164 0.0164
Entamoeba histolytica diacylglycerol kinase, putative 0.0037 0.0305 0.0189
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0118 0.0499
Echinococcus multilocularis polycomb protein SCMH1 0.0053 0.0473 0.0473
Echinococcus granulosus ceramide kinase 0.0037 0.0305 0.0305
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0297 0.0297
Loa Loa (eye worm) hypothetical protein 0.0037 0.0305 0.0301
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0138 0.1386 0.4445
Schistosoma mansoni jumonji/arid domain-containing protein 0.0058 0.0534 0.0534
Brugia malayi diacylglycerol kinase 0.0037 0.0305 0.1307
Leishmania major diacylglycerol kinase-like protein 0.0037 0.0305 0.0784
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0293 0.3027 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0164 0.0159
Trypanosoma cruzi diacylglycerol kinase-like protein, putative 0.0037 0.0305 0.0784
Trypanosoma cruzi diacylglycerol kinase, putative 0.0037 0.0305 0.0784
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0164 0.0694
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0097 0.0945 0.0945
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0164 0.0164
Loa Loa (eye worm) jmjC domain-containing protein 0.0058 0.0534 0.053
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0118 0.0114
Echinococcus granulosus cpg binding protein 0.0029 0.0226 0.0226
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0097 0.0945 0.4069
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0097 0.0945 0.0941

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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