Detailed information for compound 562747

Basic information

Technical information
  • TDR Targets ID: 562747
  • Name: 3-(5-nitro-2-furyl)propanamide
  • MW: 184.149 | Formula: C7H8N2O4
  • H donors: 1 H acceptors: 3 LogP: 0.29 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: NC(=O)CCc1ccc(o1)[N+](=O)[O-]
  • InChi: 1S/C7H8N2O4/c8-6(10)3-1-5-2-4-7(13-5)9(11)12/h2,4H,1,3H2,(H2,8,10)
  • InChiKey: HJILMZFPPNJGAI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-(5-nitrofuran-2-yl)propanamide
  • 3-(5-nitro-2-furyl)propionamide
  • 5-nitro-2-furylpropionamide
  • 39965-26-9
  • 2-Furanpropanamide, 5-nitro-

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica diacylglycerol kinase, putative 0.0032 0.0094 0.0235
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.041 0.1954 0.4872
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0055 0.0206 1
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0055 0.0206 0.2803
Trichomonas vaginalis diacylglycerol kinase, epsilon, putative 0.0032 0.0094 0.0421
Echinococcus multilocularis lysosomal alpha glucosidase 0.0159 0.0718 0.0711
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0055 0.0206 0.1163
Schistosoma mansoni hypothetical protein 0.0331 0.1566 0.156
Plasmodium falciparum thioredoxin reductase 0.0055 0.0206 0.2803
Trichomonas vaginalis CAMK family protein kinase 0.0372 0.1768 0.792
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0011 0.0057
Mycobacterium tuberculosis Probable reductase 0.0361 0.1715 0.4265
Leishmania major 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0024 0.0055 0.0311
Schistosoma mansoni cpg binding protein 0.003 0.0082 0.0075
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0099 0.0507
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0109 0.0616
Echinococcus multilocularis dnaJ subfamily B 0.04 0.1906 0.19
Plasmodium falciparum thioredoxin reductase 0.0158 0.0715 1
Echinococcus multilocularis Endoplasmic reticulum oxidoreductin 1 0.0052 0.0193 0.0186
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0015 0.0007 0.004
Trichomonas vaginalis CAMK family protein kinase 0.0184 0.0843 0.3774
Schistosoma mansoni hypothetical protein 0.0015 0.0011 0.0004
Onchocerca volvulus Ceramide kinase 1 homolog 0.0032 0.0094 0.0421
Brugia malayi Endoplasmic Reticulum Oxidoreductin 1 0.0052 0.0193 0.0989
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0059 0.0227 0.0221
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0055 0.0206 0.0199
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.006 0.0232 0.1311
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.0015 0.0007 0.004
Brugia malayi Pre-SET motif family protein 0.041 0.1954 1
Echinococcus granulosus Diacylglycerol kinase zeta 0.0032 0.0094 0.0087
Trypanosoma brucei NADH dehydrogenase 0.0015 0.0007 0.004
Trichomonas vaginalis apoptosis inducing factor, putative 0.0015 0.0007 0.0032
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0113 0.0505
Schistosoma mansoni sphingosine kinase A B 0.0828 0.4011 0.4006
Echinococcus granulosus cpg binding protein 0.003 0.0082 0.0075
Trichomonas vaginalis bmru protein, putative 0.0032 0.0094 0.0421
Loa Loa (eye worm) hypothetical protein 0.0015 0.0007 0.0018
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.0109 0.0272
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0402 0.1913 1
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0046 0.0164 0.0392
Mycobacterium tuberculosis Diacylglycerol kinase 0.0032 0.0094 0.0217
Echinococcus multilocularis GPCR, family 2 0.0015 0.0011 0.0004
Trypanosoma cruzi diacylglycerol kinase, putative 0.0032 0.0094 0.0532
Echinococcus multilocularis lysosomal alpha glucosidase 0.0159 0.0718 0.0711
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0015 0.0007 0.0018
Trichomonas vaginalis CAMK family protein kinase 0.0372 0.1768 0.792
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.004 0.0134 0.0685
Onchocerca volvulus 0.0015 0.0007 0.0032
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0055 0.0206 0.1163
Echinococcus multilocularis acylglycerol kinase, mitochondrial 0.0032 0.0094 0.0087
Brugia malayi CXXC zinc finger family protein 0.0028 0.0074 0.0377
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0113 0.0106
Mycobacterium tuberculosis Conserved protein 0.0024 0.0055 0.0119
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.0011 0.0004
Schistosoma mansoni diacylglycerol kinase zeta iota 0.0032 0.0094 0.0087
Trichomonas vaginalis glutamate synthase, putative 0.0015 0.0007 0.0032
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0113 0.0638
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0046 0.0164 0.2216
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0015 0.0007 0.0032
Schistosoma mansoni alpha-glucosidase 0.0137 0.0609 0.0602
Loa Loa (eye worm) inositol-1 0.0036 0.0113 0.0281
Schistosoma mansoni sphingoid long chain base kinase 0.0828 0.4011 0.4006
Leishmania major sphingosine kinase A, B, putative 0.0032 0.0094 0.0532
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0055 0.0206 0.1053
Loa Loa (eye worm) thioredoxin reductase 0.0158 0.0715 0.1784
Echinococcus multilocularis Diacylglycerol kinase zeta 0.0032 0.0094 0.0087
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0024 0.0055 0.0311
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0015 0.0007 0.0036
Trypanosoma cruzi endoplasmic reticulum oxidoreductin, putative 0.0052 0.0193 0.1092
Schistosoma mansoni glutaminase 0.0267 0.1248 0.1242
Schistosoma mansoni hypothetical protein 0.0032 0.0094 0.0087
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0046 0.0164 0.2216
Loa Loa (eye worm) hypothetical protein 0.0165 0.0749 0.1867
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0046 0.0164 0.1179
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.0015 0.0007 0.004
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0057 0.0214 0.0207
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0015 0.0007 0.0032
Schistosoma mansoni microtubule-associated protein tau 0.2045 1 1
Leishmania major hypothetical protein, conserved 0.0032 0.0094 0.0532
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0055 0.0206 0.1163
Trypanosoma brucei diacylglycerol kinase, putative 0.0032 0.0094 0.0532
Echinococcus granulosus geminin 0.0331 0.1566 0.156
Treponema pallidum NADH oxidase 0.0055 0.0206 0.1491
Giardia lamblia Fructose-bisphosphate aldolase 0.0285 0.1339 0.7564
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0055 0.0206 0.2803
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0032 0.0094 0.0457
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0024 0.0055 0.0119
Toxoplasma gondii diacylglycerol kinase, putative 0.0032 0.0094 0.1228
Loa Loa (eye worm) hypothetical protein 0.0015 0.0011 0.0028
Plasmodium vivax diacylglycerol kinase, putative 0.0032 0.0094 0.1228
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0109 0.0488
Mycobacterium ulcerans citrate lyase beta subunit, CitE_2 0.0024 0.0055 0.0119
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.0208 0.2838
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0024 0.0055 0.0119
Plasmodium falciparum glutathione reductase 0.0158 0.0715 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0285 0.1339 0.5998
Brugia malayi Ceramide kinase 0.0032 0.0094 0.0481
Loa Loa (eye worm) hypothetical protein 0.0033 0.0099 0.0247
Onchocerca volvulus 0.0467 0.2232 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0055 0.0206 0.1163
Trypanosoma cruzi Diacylglycerol kinase catalytic domain containing protein, putative 0.0032 0.0094 0.0532
Trypanosoma brucei hypothetical protein, conserved 0.0211 0.0974 0.5508
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0139 0.0621 0.3221
Loa Loa (eye worm) glutathione reductase 0.0158 0.0715 0.1784
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0113 0.0638
Echinococcus granulosus Diacylglycerol kinase theta 0.0032 0.0094 0.0087
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0232 0.0225
Plasmodium vivax diacylglycerol kinase, putative 0.0032 0.0094 0.1228
Loa Loa (eye worm) programmed cell death 8 0.0015 0.0007 0.0018
Trichomonas vaginalis glutaminase, putative 0.0267 0.1248 0.5592
Trichomonas vaginalis CAMK family protein kinase 0.0372 0.1768 0.792
Loa Loa (eye worm) diacylglycerol kinase 2 0.0032 0.0094 0.0235
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.0109 0.0272
Mycobacterium ulcerans hypothetical protein 0.0024 0.0055 0.0119
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0015 0.0007 0.004
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0015 0.0007 0.004
Echinococcus granulosus ceramide kinase 0.0032 0.0094 0.0087
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0055 0.0206 0.1163
Leishmania major hypothetical protein, conserved 0.0015 0.0007 0.004
Echinococcus multilocularis citrate lyase subunit beta protein 0.0024 0.0055 0.0048
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0011 0.0028
Leishmania major diacylglycerol kinase-like protein 0.0032 0.0094 0.0532
Schistosoma mansoni kinase 0.0189 0.0867 0.086
Echinococcus granulosus acylglycerol kinase mitochondrial 0.0032 0.0094 0.0087
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0055 0.0206 0.2803
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0232 0.0561
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0055 0.0206 0.1163
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0074 0.0184
Mycobacterium ulcerans hypothetical protein 0.0828 0.4011 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0055 0.0206 0.1163
Treponema pallidum fructose-bisphosphate aldolase 0.0285 0.1339 1
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0055 0.0206 0.2803
Mycobacterium tuberculosis Probable oxidoreductase 0.0402 0.1913 0.4761
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0109 0.0488
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0015 0.0007 0.0032
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0175 0.0436
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0055 0.0206 0.1163
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0055 0.0206 0.0199
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0015 0.0007 0.0032
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0011 0.0057
Leishmania major hypothetical protein, conserved 0.0015 0.0007 0.004
Plasmodium vivax glutathione reductase, putative 0.0158 0.0715 1
Schistosoma mansoni hypothetical protein 0.04 0.1906 0.19
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0055 0.0206 0.1163
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.0113 0.0264
Trypanosoma cruzi hypothetical protein, conserved 0.0211 0.0974 0.5508
Schistosoma mansoni diacylglycerol kinase theta 0.0032 0.0094 0.0087
Trichomonas vaginalis CAMK family protein kinase 0.0372 0.1768 0.792
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0361 0.1715 0.4265
Trypanosoma cruzi trypanothione reductase, putative 0.0158 0.0715 0.4046
Echinococcus granulosus lysosomal alpha glucosidase 0.0159 0.0718 0.0711
Mycobacterium tuberculosis Probable dehydrogenase 0.0361 0.1715 0.4265
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0139 0.0621 0.1534
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.0015 0.0007 0.004
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0372 0.1768 0.4409
Echinococcus granulosus neutral alpha glucosidase AB 0.0035 0.0109 0.0102
Brugia malayi Inositol-1 0.0036 0.0113 0.0577
Schistosoma mansoni diacylglycerol kinase theta 0.0032 0.0094 0.0087
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0402 0.1913 0.4761
Schistosoma mansoni ero1-related 0.0052 0.0193 0.0186
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0059 0.0227 0.0221
Onchocerca volvulus 0.0092 0.0388 0.1738
Trichomonas vaginalis sphingosine kinase, putative 0.0032 0.0094 0.0421
Loa Loa (eye worm) hypothetical protein 0.0032 0.0094 0.0235
Trichomonas vaginalis maltase-glucoamylase, putative 0.0035 0.0109 0.0488
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0046 0.0164 0.7906
Leishmania major trypanothione reductase 0.0158 0.0715 0.4046
Schistosoma mansoni hypothetical protein 0.0015 0.0011 0.0004
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0372 0.1768 1
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0158 0.0715 0.1769
Trichomonas vaginalis mercuric reductase, putative 0.0055 0.0206 0.0921
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0015 0.0007 0.0018
Trypanosoma cruzi hypothetical protein, conserved 0.0015 0.0007 0.004
Brugia malayi hypothetical protein 0.0032 0.0094 0.0481
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0232 0.0225
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0015 0.0007 0.0036
Loa Loa (eye worm) hypothetical protein 0.0059 0.0227 0.0567
Trypanosoma brucei polo-like protein kinase 0.0372 0.1768 1
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.0109 0.0488
Leishmania major endoplasmic reticulum oxidoreductin, putative 0.0052 0.0193 0.1092
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0361 0.1715 0.8958
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.0113 0.0281
Brugia malayi Thioredoxin reductase 0.0158 0.0715 0.3661
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.006 0.0232 0.0561
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0109 0.0616
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.0109 0.0488
Echinococcus multilocularis geminin 0.0331 0.1566 0.156
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0285 0.1339 0.5998
Trypanosoma cruzi diacylglycerol kinase-like protein, putative 0.0032 0.0094 0.0532
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0165 0.0749 0.3831
Echinococcus multilocularis Diacylglycerol kinase theta 0.0032 0.0094 0.0087
Leishmania major alpha glucosidase II subunit, putative 0.0035 0.0109 0.0616
Trypanosoma cruzi hypothetical protein, conserved 0.0032 0.0094 0.0532
Brugia malayi Pre-SET motif family protein 0.0059 0.0227 0.1164
Schistosoma mansoni inositol monophosphatase 0.0036 0.0113 0.0106
Trichomonas vaginalis glutathione reductase, putative 0.0055 0.0206 0.0921
Schistosoma mansoni hypothetical protein 0.0015 0.0011 0.0004
Loa Loa (eye worm) ceramide kinase 0.0032 0.0094 0.0235
Echinococcus multilocularis cpg binding protein 0.003 0.0082 0.0075
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0015 0.0007 0.004
Loa Loa (eye worm) glutaminase 0.0267 0.1248 0.3112
Entamoeba histolytica diacylglycerol kinase, putative 0.0032 0.0094 0.0235
Echinococcus granulosus Endoplasmic reticulum oxidoreductin 1 0.0052 0.0193 0.0186
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.0015 0.0007 0.0018
Toxoplasma gondii thioredoxin reductase 0.0158 0.0715 1
Entamoeba histolytica diacylglycerol kinase, putative 0.0032 0.0094 0.0235
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.0011 0.0004
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0015 0.0007 0.0036
Echinococcus granulosus sphingosine kinase 1 0.0828 0.4011 0.4006
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0035 0.0109 0.0272
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0165 0.0749 0.0742
Loa Loa (eye worm) hypothetical protein 0.0049 0.0175 0.0436
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0285 0.1339 0.5998
Schistosoma mansoni cpg binding protein 0.0028 0.0074 0.0067
Echinococcus multilocularis L aminoadipate semialdehyde 0.0165 0.0749 0.0742
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0055 0.0206 0.1163
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0055 0.0206 0.1163
Trypanosoma brucei hypothetical protein, conserved 0.0015 0.0007 0.004
Trichomonas vaginalis bmru protein, putative 0.0032 0.0094 0.0421
Leishmania major phosphopantetheinyl transferase-like protein 0.0046 0.0164 0.0928
Entamoeba histolytica disulphide oxidoreductase, putative 0.0015 0.0007 0.0018
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0372 0.1768 0.1762
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0055 0.0206 0.1163
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0372 0.1768 0.1762
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0046 0.0164 0.2216
Trypanosoma cruzi diacylglycerol kinase, putative 0.0032 0.0094 0.0532
Loa Loa (eye worm) hypothetical protein 0.0052 0.0193 0.0482
Trypanosoma cruzi polo-like protein kinase, putative 0.0372 0.1768 1
Trypanosoma cruzi NADH dehydrogenase, putative 0.0015 0.0007 0.004
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0015 0.0007 0.0018
Trichomonas vaginalis sucrase-isomaltase, putative 0.0035 0.0109 0.0488
Trichomonas vaginalis set domain proteins, putative 0.0467 0.2232 1
Leishmania major NADH dehydrogenase, putative 0.0015 0.0007 0.004
Brugia malayi glutaminase DH11.1 0.0267 0.1248 0.6389
Schistosoma mansoni cpg binding protein 0.003 0.0082 0.0075
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0032 0.0094 0.0217
Schistosoma mansoni alpha-glucosidase 0.0137 0.0609 0.0602
Mycobacterium leprae conserved hypothetical protein 0.0046 0.0164 0.0824
Trichomonas vaginalis diacylglycerol kinase, putative 0.0032 0.0094 0.0421
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.006 0.0232 0.0225
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0113 0.0106
Echinococcus multilocularis neutral alpha glucosidase AB 0.0035 0.0109 0.0102
Trichomonas vaginalis glutamate synthase, putative 0.0015 0.0007 0.0032
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0109 0.0488
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0015 0.0007 0.0032
Loa Loa (eye worm) hypothetical protein 0.0828 0.4011 1
Leishmania major hypothetical protein, conserved 0.0015 0.0007 0.004
Brugia malayi diacylglycerol kinase 0.0032 0.0094 0.0481
Mycobacterium ulcerans glutaminase 0.0267 0.1248 0.31
Echinococcus multilocularis ceramide kinase 0.0032 0.0094 0.0087
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0046 0.0164 0.0392
Plasmodium vivax thioredoxin reductase, putative 0.0158 0.0715 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0055 0.0206 0.1163
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.0239 0.0233
Plasmodium falciparum endoplasmic reticulum oxidoreductin, putative 0.0052 0.0193 0.2627
Leishmania major hypothetical protein, conserved 0.0211 0.0974 0.5508
Brugia malayi glutathione reductase 0.0158 0.0715 0.3661
Trypanosoma cruzi NADH dehydrogenase, putative 0.0015 0.0007 0.004
Schistosoma mansoni serine/threonine protein kinase 0.0372 0.1768 0.1762
Trichomonas vaginalis CAMK family protein kinase 0.0372 0.1768 0.792
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.004 0.0134 0.0685
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0015 0.0007 0.0032
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0036 0.0113 0.532
Trypanosoma cruzi hypothetical protein, conserved 0.0015 0.0007 0.004
Trypanosoma brucei hypothetical protein, conserved 0.0046 0.0164 0.0928
Onchocerca volvulus Serine\/threonine kinase homolog 0.0372 0.1768 0.792
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0159 0.0718 0.179
Echinococcus granulosus citrate lyase subunit beta protein 0.0024 0.0055 0.0048
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0139 0.0621 0.1534
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0015 0.0007 0.0032
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0055 0.0206 0.0496
Echinococcus granulosus L aminoadipate semialdehyde 0.0165 0.0749 0.0742
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0059 0.0227 0.0221
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.0113 0.0505
Plasmodium vivax SET domain protein, putative 0.0059 0.0227 0.3111
Schistosoma mansoni hypothetical protein 0.0033 0.0099 0.0092
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0015 0.0007 0.0018
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0361 0.1715 0.4265
Trypanosoma brucei pol-associated gene 1 0.0052 0.0193 0.1092
Trichomonas vaginalis diacylglycerol kinase, zeta, iota, putative 0.0032 0.0094 0.0421
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0175 0.0894
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0113 0.0638
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0175 0.0894
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0361 0.1715 0.4265
Giardia lamblia Kinase, PLK 0.0372 0.1768 1
Toxoplasma gondii diacylglycerol kinase catalytic domain-containing protein 0.0032 0.0094 0.1228
Onchocerca volvulus 0.0028 0.0074 0.033
Echinococcus multilocularis thioredoxin glutathione reductase 0.016 0.0723 0.0716
Brugia malayi Diacylglycerol kinase protein 2 0.0032 0.0094 0.0481
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0285 0.1339 0.3339
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0055 0.0206 0.1163
Schistosoma mansoni proteasome subunit alpha 6 (T01 family) 0.0032 0.0094 0.0087
Trypanosoma brucei Sphingosine kinase 0.0032 0.0094 0.0532
Echinococcus granulosus GPCR family 2 0.0015 0.0011 0.0004
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0015 0.0007 0.0032
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0109 0.0488
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.006 0.0232 0.0225
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0015 0.0007 0.0018
Trypanosoma cruzi hypothetical protein, conserved 0.0211 0.0974 0.5508
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.0011 0.0004
Trypanosoma brucei trypanothione reductase 0.0158 0.0715 0.4046
Mycobacterium tuberculosis Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase) 0.0024 0.0055 0.0119
Plasmodium falciparum diacylglycerol kinase, putative 0.0032 0.0094 0.1228
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0109 0.0488
Trichomonas vaginalis diacylglycerol kinase, zeta, iota, putative 0.0032 0.0094 0.0421
Trichomonas vaginalis Citrate lyase beta chain, putative 0.0024 0.0055 0.0246
Trichomonas vaginalis sphingosine kinase, putative 0.0032 0.0094 0.0421
Giardia lamblia NADH oxidase lateral transfer candidate 0.0055 0.0206 0.1128
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0055 0.0206 0.0496
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0113 0.1491
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0055 0.0206 0.0496
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0035 0.0109 0.1438
Trypanosoma cruzi polo-like protein kinase, putative 0.0372 0.1768 1
Brugia malayi diacylglycerol kinase 0.0032 0.0094 0.0481
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0285 0.1339 0.5998
Mycobacterium ulcerans hypothetical protein 0.0024 0.0055 0.0119
Leishmania major diacylglycerol kinase, putative 0.0032 0.0094 0.0532
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.0015 0.0007 0.004
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0055 0.0206 1
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0046 0.0164 0.0392
Mycobacterium tuberculosis Conserved protein 0.0828 0.4011 1
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0015 0.0007 0.004
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0094 0.0421
Entamoeba histolytica thioredoxin reductase, putative 0.0015 0.0007 0.0018
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0059 0.0227 0.0221
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0285 0.1339 0.5998
Trichomonas vaginalis diacylglycerol kinase, putative 0.0032 0.0094 0.0421
Entamoeba histolytica hypothetical protein, conserved 0.0828 0.4011 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.0094 0.0235
Schistosoma mansoni hypothetical protein 0.0331 0.1566 0.156
Toxoplasma gondii NADPH-glutathione reductase 0.0055 0.0206 0.2803
Trichomonas vaginalis CAMK family protein kinase 0.0372 0.1768 0.792
Trypanosoma cruzi diacylglycerol kinase-like protein, putative 0.0032 0.0094 0.0532
Plasmodium falciparum diacylglycerol kinase, putative 0.0032 0.0094 0.1228
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0232 0.0561
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0015 0.0007 0.004
Loa Loa (eye worm) hypothetical protein 0.0032 0.0094 0.0235
Onchocerca volvulus 0.0032 0.0094 0.0421
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0285 0.1339 0.5998
Onchocerca volvulus 0.0165 0.0749 0.3353
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0046 0.0164 0.7906
Mycobacterium ulcerans diacylglycerol kinase 0.0032 0.0094 0.0217
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0361 0.1715 0.4265
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0059 0.0227 0.0221
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0055 0.0206 0.1163
Trypanosoma cruzi trypanothione reductase, putative 0.0055 0.0206 0.1163
Trichomonas vaginalis CAMK family protein kinase 0.0184 0.0843 0.3774
Schistosoma mansoni hypothetical protein 0.0015 0.0011 0.0004
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0055 0.0206 1
Onchocerca volvulus 0.0059 0.0227 0.1019
Plasmodium falciparum glutathione reductase 0.0055 0.0206 0.2803
Echinococcus multilocularis sphingosine kinase 1 0.0828 0.4011 0.4006
Leishmania major hypothetical protein, conserved 0.0032 0.0094 0.0532
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0046 0.0164 0.2216
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0055 0.0206 0.2803
Toxoplasma gondii aldehyde dehydrogenase 0.006 0.0232 0.3172
Brugia malayi Glycosyl hydrolases family 31 protein 0.0035 0.0109 0.0558
Echinococcus granulosus thioredoxin glutathione reductase 0.016 0.0723 0.0716
Toxoplasma gondii endoplasmic reticulum oxidoreductin, putative 0.0052 0.0193 0.2627
Brugia malayi Glycosyl hydrolases family 31 protein 0.0159 0.0718 0.3674
Brugia malayi serine/threonine-protein kinase plk-2 0.0372 0.1768 0.9049
Plasmodium vivax endoplasmic reticulum oxidoreductin, putative 0.0052 0.0193 0.2627
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0055 0.0206 0.0496
Trypanosoma brucei Diacylglycerol kinase catalytic domain containing protein, putative 0.0032 0.0094 0.0532
Brugia malayi glutamate synthase 0.0015 0.0007 0.0036
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0024 0.0055 0.0311
Echinococcus granulosus dnaJ subfamily B 0.04 0.1906 0.19
Trypanosoma brucei hypothetical protein, conserved 0.0032 0.0094 0.0532
Schistosoma mansoni inositol monophosphatase 0.0036 0.0113 0.0106
Entamoeba histolytica hypothetical protein 0.0046 0.0164 0.0409
Toxoplasma gondii diacylglycerol kinase accessory domain (presumed) domain-containing protein 0.0032 0.0094 0.1228
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0113 0.0505
Trichomonas vaginalis CAMK family protein kinase 0.0372 0.1768 0.792
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.0011 0.0004
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0285 0.1339 0.5998
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0059 0.0227 0.0221
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0015 0.0007 0.0032
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0015 0.0007 0.0032
Echinococcus granulosus histone lysine methyltransferase setb 0.0059 0.0227 0.0221
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0402 0.1913 0.4761
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0232 0.0561
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.0015 0.0007 0.004
Brugia malayi Eye-specific diacylglycerol kinase 0.0032 0.0094 0.0481
Trypanosoma cruzi Sphingosine kinase 0.0032 0.0094 0.0532
Trypanosoma brucei glucosidase, putative 0.0035 0.0109 0.0616
Echinococcus multilocularis microtubule associated protein 2 0.2045 1 1
Entamoeba histolytica diacylglycerol kinase, putative 0.0032 0.0094 0.0235
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0113 0.0638
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0055 0.0206 0.1163
Trypanosoma cruzi Sphingosine kinase 0.0032 0.0094 0.0532
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0285 0.1339 0.3339
Schistosoma mansoni alpha glucosidase 0.0035 0.0109 0.0102
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0059 0.0227 0.3111
Loa Loa (eye worm) eye-specific diacylglycerol kinase 0.0032 0.0094 0.0235
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0285 0.1339 0.5998
Loa Loa (eye worm) glutaminase 2 0.0267 0.1248 0.3112
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0055 0.0206 0.0199
Entamoeba histolytica serine/threonine protein kinase, putative 0.0372 0.1768 0.4409

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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