Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Serotonin transporter | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0285 | 0.1284 | 0.4683 | |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0295 | 0.137 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0285 | 0.1284 | 0.0901 |
Echinococcus multilocularis | beta galactosidase | 0.0638 | 0.4363 | 1 |
Mycobacterium tuberculosis | Conserved protein | 0.0138 | 0 | 0.5 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.058 | 0.3854 | 0.3584 |
Loa Loa (eye worm) | TRE-1 protein | 0.0285 | 0.1284 | 0.0901 |
Trichomonas vaginalis | trehalase, putative | 0.0285 | 0.1284 | 0.9035 |
Schistosoma mansoni | beta-galactosidase | 0.0638 | 0.4363 | 1 |
Loa Loa (eye worm) | TRE-2 protein | 0.0285 | 0.1284 | 0.0901 |
Onchocerca volvulus | 0.039 | 0.2193 | 1 | |
Trichomonas vaginalis | conserved hypothetical protein | 0.0285 | 0.1284 | 0.9035 |
Plasmodium falciparum | conserved Plasmodium protein, unknown function | 0.0195 | 0.0494 | 0.5 |
Echinococcus granulosus | beta galactosidase | 0.0638 | 0.4363 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0295 | 0.137 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0295 | 0.137 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0204 | 0.0574 | 0.1027 |
Leishmania major | glycosyl hydrolase, putative | 0.0138 | 0 | 0.5 |
Mycobacterium leprae | Possible hydrolase | 0.0138 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0285 | 0.1284 | 0.0901 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0295 | 0.137 | 1 |
Loa Loa (eye worm) | trehalase | 0.0285 | 0.1284 | 0.0901 |
Plasmodium vivax | hypothetical protein, conserved | 0.0195 | 0.0494 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0204 | 0.0574 | 0.1027 |
Loa Loa (eye worm) | hypothetical protein | 0.0285 | 0.1284 | 0.0901 |
Onchocerca volvulus | Trehalase homolog | 0.0285 | 0.1284 | 0.4683 |
Loa Loa (eye worm) | hypothetical protein | 0.0285 | 0.1284 | 0.0901 |
Brugia malayi | O-Glycosyl hydrolase family 30 protein | 0.0295 | 0.137 | 0.0333 |
Loa Loa (eye worm) | hypothetical protein | 0.0285 | 0.1284 | 0.0901 |
Loa Loa (eye worm) | trehalase | 0.0285 | 0.1284 | 0.0901 |
Trypanosoma brucei | glycosyl hydrolase, putative | 0.0138 | 0 | 0.5 |
Onchocerca volvulus | 0.0285 | 0.1284 | 0.4683 | |
Onchocerca volvulus | 0.0285 | 0.1284 | 0.4683 | |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.058 | 0.3854 | 1 |
Onchocerca volvulus | 0.0285 | 0.1284 | 0.4683 | |
Trypanosoma cruzi | glycosyl hydrolase, putative | 0.0138 | 0 | 0.5 |
Loa Loa (eye worm) | trehalase | 0.0285 | 0.1284 | 0.0901 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0295 | 0.137 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0638 | 0.4363 | 0.4115 |
Onchocerca volvulus | 0.0285 | 0.1284 | 0.4683 | |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0295 | 0.137 | 1 |
Loa Loa (eye worm) | O-glycosyl hydrolase family 30 protein | 0.0295 | 0.137 | 0.0991 |
Mycobacterium ulcerans | glycosyl hydrolase | 0.0138 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 12.62 nM | Inhibition of [3H]-citalopram binding to Serotonin transporter of rat cerebral cortex | ChEMBL. | 10915050 |
Ki (binding) | = 12.62 nM | Inhibition of [3H]-citalopram binding to Serotonin transporter of rat cerebral cortex | ChEMBL. | 10915050 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.