Detailed information for compound 570872

Basic information

Technical information
  • TDR Targets ID: 570872
  • Name: 2-amino-5-[(2S,3R,4S,5R)-3,4-dihydroxy-5-(hyd roxymethyl)tetrahydrofuran-2-yl]-1H-pyrimidin -6-one
  • MW: 243.217 | Formula: C9H13N3O5
  • H donors: 5 H acceptors: 4 LogP: -3.13 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)c1cnc([nH]c1=O)N
  • InChi: 1S/C9H13N3O5/c10-9-11-1-3(8(16)12-9)7-6(15)5(14)4(2-13)17-7/h1,4-7,13-15H,2H2,(H3,10,11,12,16)/t4-,5-,6-,7+/m1/s1
  • InChiKey: MPDKOGQMQLSNOF-GBNDHIKLSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-amino-5-[(2S,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)-2-tetrahydrofuranyl]-1H-pyrimidin-6-one
  • 2-azanyl-5-[(2S,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1H-pyrimidin-6-one
  • 2-amino-5-[(2S,3R,4S,5R)-3,4-dihydroxy-5-methylol-tetrahydrofuran-2-yl]-1H-pyrimidin-6-one
  • 2-amino-5-[(2S,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1H-pyrimidin-6-one
  • pseudoisocytidine
  • 2-amino-5-[(2S,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-3H-pyrimidin-4-one
  • 2-amino-5-[(2S,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-3H-pyrimidin-4-one
  • 2-amino-5-[(2S,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)-2-tetrahydrofuranyl]-3H-pyrimidin-4-one
  • 2-amino-5-[(2S,3R,4S,5R)-3,4-dihydroxy-5-methylol-tetrahydrofuran-2-yl]-3H-pyrimidin-4-one
  • 57100-18-2
  • 4-(1H)-Pyrimidinone, 2-amino-5-.beta.-D-ribofuranosyl-
  • 59464-15-2 (HCL)
  • AIDS-014465
  • AIDS014465
  • NSC279852 (HCL)
  • 4(1H)-Pyrimidinone, 2-amino-5-beta-D-ribofuranosyl-
  • 5-(beta-D-Ribofuranosyl)isocytosine
  • psi-Isocytidine

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0065 0.0775
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0007 0.0086 0.0115
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0007 0.0086 0.1021
Mycobacterium ulcerans acyl-CoA synthetase 0.0007 0.0086 0.0115
Mycobacterium ulcerans acyl-CoA synthetase 0.0007 0.0086 0.0115
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0025 0.0522 0.07
Echinococcus granulosus mixed lineage leukemia protein mll 0.0007 0.0081 0.0081
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0025 0.0522 0.07
Schistosoma mansoni cpg binding protein 0.003 0.0654 0.0654
Mycobacterium tuberculosis Conserved protein 0.0038 0.0843 0.1129
Plasmodium vivax acetyl-CoA synthetase, putative 0.0007 0.0086 0.0115
Mycobacterium tuberculosis Probable esterase LipL 0.0038 0.0843 0.1129
Schistosoma mansoni hypothetical protein 0.0409 1 1
Loa Loa (eye worm) beta-lactamase 0.0038 0.0843 0.5741
Entamoeba histolytica fatty acid elongase, putative 0.004 0.0886 1
Mycobacterium ulcerans hypothetical protein 0.0038 0.0843 0.1129
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0065 0.0775
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0341 0.0457
Mycobacterium ulcerans esterase/lipase LipP 0.0038 0.0843 0.1129
Mycobacterium ulcerans 3-oxoacyl-ACP synthase 0.0306 0.7462 1
Onchocerca volvulus 0.0038 0.0843 1
Wolbachia endosymbiont of Brugia malayi 3-oxoacyl-ACP synthase 0.0306 0.7462 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0522 0.3558
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0007 0.0086 0.0586
Mycobacterium ulcerans acyl-CoA synthetase 0.0007 0.0086 0.0115
Toxoplasma gondii ABC1 family protein 0.0038 0.0843 0.6006
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0007 0.0086 0.0115
Plasmodium falciparum beta-ketoacyl-ACP synthase III 0.0306 0.7462 1
Brugia malayi RNA binding protein 0.0063 0.1468 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0366 0.2495
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0007 0.0086 0.0086
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0025 0.0522 0.07
Mycobacterium ulcerans lipase LipD 0.0038 0.0843 0.1129
Loa Loa (eye worm) hypothetical protein 0.0038 0.0843 0.5741
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0007 0.0086 0.1021
Toxoplasma gondii propionate-CoA ligase 0.0007 0.0086 0.0613
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0007 0.0086 0.0086
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0522 0.07
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0522 0.07
Mycobacterium tuberculosis Probable lipase LipE 0.0038 0.0843 0.1129
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.1248 0.889
Entamoeba histolytica fatty acid elongase, putative 0.004 0.0886 1
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0007 0.0086 0.0115
Loa Loa (eye worm) hypothetical protein 0.0038 0.0843 0.5741
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0007 0.0086 0.0115
Brugia malayi AMP-binding enzyme family protein 0.0007 0.0086 0.0586
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.0086 0.0115
Schistosoma mansoni tar DNA-binding protein 0.0063 0.1468 0.1468
Giardia lamblia Hypothetical protein 0.0004 0 0.5
Mycobacterium tuberculosis Probable hydrolase 0.0038 0.0843 0.1129
Brugia malayi RNA recognition motif domain containing protein 0.0063 0.1468 1
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.1403 0.1403
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0843 1
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0065 0.0775
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0007 0.0086 0.1021
Mycobacterium ulcerans acyl-CoA synthetase 0.0007 0.0086 0.0115
Brugia malayi AMP-binding enzyme family protein 0.0007 0.0086 0.0586
Toxoplasma gondii aldehyde dehydrogenase 0.0061 0.1403 1
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0007 0.0086 0.1021
Mycobacterium ulcerans beta-ketoacyl synthase-like protein 0.0306 0.7462 1
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0007 0.0086 0.1021
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0522 0.3558
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0065 0.0775
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0007 0.0086 0.1021
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0843 1
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0007 0.0086 0.0115
Mycobacterium ulcerans acetyl-CoA synthetase 0.0007 0.0086 0.0115
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0007 0.0086 0.0115
Plasmodium falciparum acyl-CoA synthetase 0.0019 0.0366 0.0491
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0341 0.0457
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.1408 0.1408
Schistosoma mansoni cpg binding protein 0.0029 0.0614 0.0614
Mycobacterium tuberculosis Conserved protein 0.0038 0.0843 0.1129
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0065 0.0775
Onchocerca volvulus 0.0038 0.0843 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0522 0.3723
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0243 0.5898 0.7904
Echinococcus multilocularis tar DNA binding protein 0.0063 0.1468 0.1468
Leishmania major acetyl-CoA synthetase, putative 0.0007 0.0086 0.0613
Onchocerca volvulus 0.0025 0.0522 0.6199
Loa Loa (eye worm) hypothetical protein 0.0007 0.0086 0.0586
Chlamydia trachomatis oxoacyl-ACP synthase III 0.0306 0.7462 1
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0061 0.1403 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0004 0.0006 0.0006
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0007 0.0081 0.0081
Schistosoma mansoni acetyl-CoA synthetase 0.0007 0.0086 0.0086
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0007 0.0086 0.0586
Plasmodium vivax beta-ketoacyl-acyl carrier protein synthase III precursor, putative 0.0306 0.7462 1
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0038 0.0843 0.1129
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0065 0.0775
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0522 0.07
Onchocerca volvulus 0.0011 0.0181 0.2152
Brugia malayi AMP-binding enzyme family protein 0.0007 0.0086 0.0586
Trichomonas vaginalis antibiotic synthetase, putative 0.0007 0.0086 0.1021
Giardia lamblia Oxidoreductase, short chain dehydrogenase/reductase family 0.0004 0 0.5
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0038 0.0843 0.5741
Loa Loa (eye worm) hypothetical protein 0.0038 0.0843 0.5741
Echinococcus multilocularis dnaJ subfamily B 0.0409 1 1
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0038 0.0843 0.5741
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0007 0.0086 0.0971
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0025 0.0522 0.6199
Loa Loa (eye worm) hypothetical protein 0.0038 0.0843 0.5741
Echinococcus multilocularis beta LACTamase domain containing family member 0.0038 0.0843 0.0843
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.0086 0.0115
Loa Loa (eye worm) oxidoreductase 0.0007 0.0086 0.0586
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0065 0.0775
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0843 1
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0061 0.1403 0.1403
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.1403 0.1881
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0522 0.5896
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0038 0.0843 0.1129
Trichomonas vaginalis helicase, putative 0.0007 0.0065 0.0775
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0843 0.0843
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.1403 0.1881
Trypanosoma brucei hypothetical protein, conserved 0.0038 0.0843 1
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0843 1
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0007 0.0086 0.0115
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0065 0.0775
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0007 0.0086 0.0115
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0061 0.1403 0.1403
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0522 0.3558
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0006 0.0061 0.0082
Trichomonas vaginalis esterase, putative 0.0038 0.0843 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0019 0.0366 0.0491
Schistosoma mansoni tar DNA-binding protein 0.0063 0.1468 0.1468
Entamoeba histolytica fatty acid elongase, putative 0.004 0.0886 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0065 0.0775
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0007 0.0086 0.0613
Mycobacterium tuberculosis Conserved protein 0.0038 0.0843 0.1129
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0007 0.0086 0.0613
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0522 0.3723
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0843 0.0843
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0007 0.0086 0.0586
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0007 0.0086 0.0115
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0843 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0007 0.0081 0.0081
Mycobacterium ulcerans acyl-CoA synthetase 0.0007 0.0086 0.0115
Trichomonas vaginalis antibiotic synthetase, putative 0.0007 0.0086 0.1021
Brugia malayi AMP-binding enzyme family protein 0.0007 0.0086 0.0586
Brugia malayi beta-lactamase family protein 0.0038 0.0843 0.5741
Schistosoma mansoni tar DNA-binding protein 0.0063 0.1468 0.1468
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.0086 0.0115
Giardia lamblia Short-chain dehydrogenase, putative 0.0004 0 0.5
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0007 0.0086 0.0613
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0843 1
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0007 0.0086 0.0115
Loa Loa (eye worm) hypothetical protein 0.0019 0.0366 0.2495
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0019 0.0366 0.0491
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0007 0.0086 0.0115
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0025 0.0522 0.07
Mycobacterium ulcerans acyl-CoA synthetase 0.0007 0.0086 0.0115
Loa Loa (eye worm) hypothetical protein 0.0019 0.0366 0.2495
Schistosoma mansoni tar DNA-binding protein 0.0063 0.1468 0.1468
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0065 0.0775
Entamoeba histolytica fatty acid elongase, putative 0.004 0.0886 1
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0007 0.0086 0.1021
Loa Loa (eye worm) hypothetical protein 0.0019 0.0366 0.2495
Brugia malayi beta-lactamase family protein 0.0038 0.0843 0.5741
Entamoeba histolytica fatty acid elongase, putative 0.004 0.0886 1
Onchocerca volvulus 0.0038 0.0843 1
Mycobacterium leprae conserved hypothetical protein 0.0038 0.0843 1
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0007 0.0086 0.0586
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0124 0.0124
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0065 0.0775
Leishmania major hypothetical protein, conserved 0.0038 0.0843 0.6006
Mycobacterium tuberculosis 3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III) 0.0306 0.7462 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0065 0.0775
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0025 0.0522 0.07
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0341 0.0457
Mycobacterium ulcerans 3-oxoacyl-ACP synthase 0.0306 0.7462 1
Loa Loa (eye worm) hypothetical protein 0.0007 0.0086 0.0586
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.0086 0.0115
Mycobacterium tuberculosis Probable lipase LipD 0.0038 0.0843 0.1129
Brugia malayi TAR-binding protein 0.0063 0.1468 1
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0025 0.0522 0.07
Onchocerca volvulus 0.0007 0.0086 0.1021
Loa Loa (eye worm) hypothetical protein 0.0025 0.0522 0.3558
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0522 0.3723
Echinococcus granulosus cpg binding protein 0.003 0.0654 0.0654
Echinococcus granulosus tar DNA binding protein 0.0063 0.1468 0.1468
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0614 0.4179
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0025 0.0522 0.6199
Onchocerca volvulus 0.0007 0.0086 0.1021
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0007 0.0086 0.0115
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0007 0.0086 0.0115
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0007 0.0086 0.1021
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0065 0.0775
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0124 0.0124
Loa Loa (eye worm) hypothetical protein 0.0038 0.0843 0.5741
Mycobacterium ulcerans acyl-CoA synthetase 0.0007 0.0086 0.0115
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.1403 0.1403
Brugia malayi CXXC zinc finger family protein 0.0029 0.0614 0.4179
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0843 1
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0065 0.0775
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0007 0.0086 0.0115
Giardia lamblia Reductase, putative 0.0004 0 0.5
Plasmodium vivax hypothetical protein, conserved 0.0038 0.0843 0.1129
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0007 0.0081 0.0081
Mycobacterium ulcerans hypothetical protein 0.0025 0.0522 0.07
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0124 0.0844
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0065 0.0775
Entamoeba histolytica acyl-coA synthetase, putative 0.0025 0.0522 0.5896
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0522 0.5896
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0065 0.0775
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0038 0.0843 0.1129
Brugia malayi beta-lactamase 0.0038 0.0843 0.5741
Mycobacterium ulcerans acyl-CoA synthetase 0.0007 0.0086 0.0115
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0007 0.0081 0.0081
Echinococcus granulosus beta LACTamase domain containing family member 0.0038 0.0843 0.0843
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0061 0.1403 0.1881
Loa Loa (eye worm) RNA binding protein 0.0063 0.1468 1
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0007 0.0086 0.0115
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0121 0.0825
Loa Loa (eye worm) hypothetical protein 0.0019 0.0366 0.2495
Loa Loa (eye worm) hypothetical protein 0.0038 0.0843 0.5741
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0038 0.0843 0.1129
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0341 0.0457
Schistosoma mansoni tar DNA-binding protein 0.0063 0.1468 0.1468
Plasmodium vivax acyl-CoA synthetase, putative 0.0019 0.0366 0.0491
Echinococcus multilocularis cpg binding protein 0.003 0.0654 0.0654
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.1403 0.1881
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0522 0.3558
Onchocerca volvulus 0.0007 0.0086 0.1021
Mycobacterium ulcerans beta-lactamase 0.0038 0.0843 0.1129
Schistosoma mansoni cpg binding protein 0.003 0.0654 0.0654
Onchocerca volvulus 0.0029 0.0614 0.7279
Loa Loa (eye worm) TAR-binding protein 0.0063 0.1468 1
Mycobacterium leprae Probable lipase LipE 0.0038 0.0843 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0522 0.3558
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0065 0.0775
Leishmania major acetyl-CoA synthetase, putative 0.0007 0.0086 0.0613
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0063 0.1468 1
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0007 0.0086 0.1021
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0007 0.0086 0.0115

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.