Detailed information for compound 570872

Basic information

Technical information
  • TDR Targets ID: 570872
  • Name: 2-amino-5-[(2S,3R,4S,5R)-3,4-dihydroxy-5-(hyd roxymethyl)tetrahydrofuran-2-yl]-1H-pyrimidin -6-one
  • MW: 243.217 | Formula: C9H13N3O5
  • H donors: 5 H acceptors: 4 LogP: -3.13 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)c1cnc([nH]c1=O)N
  • InChi: 1S/C9H13N3O5/c10-9-11-1-3(8(16)12-9)7-6(15)5(14)4(2-13)17-7/h1,4-7,13-15H,2H2,(H3,10,11,12,16)/t4-,5-,6-,7+/m1/s1
  • InChiKey: MPDKOGQMQLSNOF-GBNDHIKLSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-amino-5-[(2S,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)-2-tetrahydrofuranyl]-1H-pyrimidin-6-one
  • 2-azanyl-5-[(2S,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1H-pyrimidin-6-one
  • 2-amino-5-[(2S,3R,4S,5R)-3,4-dihydroxy-5-methylol-tetrahydrofuran-2-yl]-1H-pyrimidin-6-one
  • 2-amino-5-[(2S,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1H-pyrimidin-6-one
  • pseudoisocytidine
  • 2-amino-5-[(2S,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-3H-pyrimidin-4-one
  • 2-amino-5-[(2S,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-3H-pyrimidin-4-one
  • 2-amino-5-[(2S,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)-2-tetrahydrofuranyl]-3H-pyrimidin-4-one
  • 2-amino-5-[(2S,3R,4S,5R)-3,4-dihydroxy-5-methylol-tetrahydrofuran-2-yl]-3H-pyrimidin-4-one
  • 57100-18-2
  • 4-(1H)-Pyrimidinone, 2-amino-5-.beta.-D-ribofuranosyl-
  • 59464-15-2 (HCL)
  • AIDS-014465
  • AIDS014465
  • NSC279852 (HCL)
  • 4(1H)-Pyrimidinone, 2-amino-5-beta-D-ribofuranosyl-
  • 5-(beta-D-Ribofuranosyl)isocytosine
  • psi-Isocytidine

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium falciparum acyl-CoA synthetase 0.0019 0.0366 0.0491
Onchocerca volvulus 0.0025 0.0522 0.6199
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0061 0.1403 1
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0038 0.0843 0.5741
Mycobacterium ulcerans acyl-CoA synthetase 0.0007 0.0086 0.0115
Onchocerca volvulus 0.0038 0.0843 1
Echinococcus multilocularis cpg binding protein 0.003 0.0654 0.0654
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0341 0.0457
Mycobacterium leprae Probable lipase LipE 0.0038 0.0843 1
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0038 0.0843 0.1129
Loa Loa (eye worm) hypothetical protein 0.0019 0.0366 0.2495
Entamoeba histolytica fatty acid elongase, putative 0.004 0.0886 1
Plasmodium vivax acetyl-CoA synthetase, putative 0.0007 0.0086 0.0115
Echinococcus granulosus beta LACTamase domain containing family member 0.0038 0.0843 0.0843
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0007 0.0086 0.1021
Toxoplasma gondii ABC1 family protein 0.0038 0.0843 0.6006
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0522 0.07
Schistosoma mansoni tar DNA-binding protein 0.0063 0.1468 0.1468
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0065 0.0775
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0522 0.07
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0121 0.0825
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0007 0.0086 0.0115
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0065 0.0775
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.0086 0.0115
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0522 0.3723
Plasmodium vivax hypothetical protein, conserved 0.0038 0.0843 0.1129
Brugia malayi RNA binding protein 0.0063 0.1468 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0007 0.0086 0.0115
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0006 0.0061 0.0082
Mycobacterium ulcerans acyl-CoA synthetase 0.0007 0.0086 0.0115
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0007 0.0086 0.0086
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0065 0.0775
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0065 0.0775
Wolbachia endosymbiont of Brugia malayi 3-oxoacyl-ACP synthase 0.0306 0.7462 1
Leishmania major hypothetical protein, conserved 0.0038 0.0843 0.6006
Mycobacterium ulcerans hypothetical protein 0.0038 0.0843 0.1129
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0007 0.0086 0.0115
Mycobacterium ulcerans 3-oxoacyl-ACP synthase 0.0306 0.7462 1
Loa Loa (eye worm) TAR-binding protein 0.0063 0.1468 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0366 0.2495
Mycobacterium ulcerans esterase/lipase LipP 0.0038 0.0843 0.1129
Toxoplasma gondii aldehyde dehydrogenase 0.0061 0.1403 1
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0007 0.0086 0.0115
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0038 0.0843 0.5741
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0065 0.0775
Entamoeba histolytica fatty acid elongase, putative 0.004 0.0886 1
Onchocerca volvulus 0.0038 0.0843 1
Mycobacterium tuberculosis Conserved protein 0.0038 0.0843 0.1129
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0007 0.0086 0.0613
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0007 0.0086 0.1021
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.1248 0.889
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0065 0.0775
Mycobacterium ulcerans acyl-CoA synthetase 0.0007 0.0086 0.0115
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0243 0.5898 0.7904
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0019 0.0366 0.0491
Mycobacterium ulcerans hypothetical protein 0.0025 0.0522 0.07
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0007 0.0086 0.0115
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0843 1
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0065 0.0775
Loa Loa (eye worm) hypothetical protein 0.0038 0.0843 0.5741
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0007 0.0086 0.0115
Loa Loa (eye worm) hypothetical protein 0.0038 0.0843 0.5741
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0007 0.0086 0.0613
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0038 0.0843 0.1129
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0038 0.0843 0.1129
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0124 0.0124
Brugia malayi beta-lactamase family protein 0.0038 0.0843 0.5741
Leishmania major acetyl-CoA synthetase, putative 0.0007 0.0086 0.0613
Schistosoma mansoni tar DNA-binding protein 0.0063 0.1468 0.1468
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0025 0.0522 0.07
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0061 0.1403 0.1881
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0007 0.0086 0.0086
Onchocerca volvulus 0.0007 0.0086 0.1021
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0025 0.0522 0.6199
Loa Loa (eye worm) RNA binding protein 0.0063 0.1468 1
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0065 0.0775
Loa Loa (eye worm) hypothetical protein 0.0038 0.0843 0.5741
Entamoeba histolytica fatty acid elongase, putative 0.004 0.0886 1
Mycobacterium ulcerans lipase LipD 0.0038 0.0843 0.1129
Plasmodium vivax beta-ketoacyl-acyl carrier protein synthase III precursor, putative 0.0306 0.7462 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0366 0.2495
Mycobacterium ulcerans beta-lactamase 0.0038 0.0843 0.1129
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0522 0.5896
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0007 0.0086 0.0115
Mycobacterium ulcerans acyl-CoA synthetase 0.0007 0.0086 0.0115
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.1403 0.1881
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.1403 0.1881
Trichomonas vaginalis esterase, putative 0.0038 0.0843 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0522 0.07
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0061 0.1403 0.1403
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0065 0.0775
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0007 0.0086 0.1021
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0007 0.0086 0.0115
Mycobacterium ulcerans 3-oxoacyl-ACP synthase 0.0306 0.7462 1
Schistosoma mansoni acetyl-CoA synthetase 0.0007 0.0086 0.0086
Mycobacterium tuberculosis Conserved protein 0.0038 0.0843 0.1129
Mycobacterium ulcerans acetyl-CoA synthetase 0.0007 0.0086 0.0115
Loa Loa (eye worm) hypothetical protein 0.0025 0.0522 0.3558
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0341 0.0457
Entamoeba histolytica acyl-coA synthetase, putative 0.0025 0.0522 0.5896
Loa Loa (eye worm) beta-lactamase 0.0038 0.0843 0.5741
Schistosoma mansoni cpg binding protein 0.003 0.0654 0.0654
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0124 0.0844
Loa Loa (eye worm) hypothetical protein 0.0007 0.0086 0.0586
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0007 0.0086 0.0586
Echinococcus granulosus cpg binding protein 0.003 0.0654 0.0654
Brugia malayi AMP-binding enzyme family protein 0.0007 0.0086 0.0586
Entamoeba histolytica fatty acid elongase, putative 0.004 0.0886 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0007 0.0081 0.0081
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0522 0.3558
Mycobacterium tuberculosis Probable lipase LipE 0.0038 0.0843 0.1129
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0065 0.0775
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0007 0.0086 0.1021
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0025 0.0522 0.6199
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0004 0.0006 0.0006
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0007 0.0086 0.0115
Mycobacterium ulcerans beta-ketoacyl synthase-like protein 0.0306 0.7462 1
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0007 0.0086 0.0115
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0522 0.3558
Toxoplasma gondii propionate-CoA ligase 0.0007 0.0086 0.0613
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0843 0.0843
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0522 0.5896
Brugia malayi RNA recognition motif domain containing protein 0.0063 0.1468 1
Giardia lamblia Oxidoreductase, short chain dehydrogenase/reductase family 0.0004 0 0.5
Mycobacterium tuberculosis Conserved protein 0.0038 0.0843 0.1129
Loa Loa (eye worm) hypothetical protein 0.0038 0.0843 0.5741
Giardia lamblia Short-chain dehydrogenase, putative 0.0004 0 0.5
Onchocerca volvulus 0.0011 0.0181 0.2152
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0843 1
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0007 0.0086 0.1021
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0061 0.1403 0.1403
Onchocerca volvulus 0.0038 0.0843 1
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0065 0.0775
Brugia malayi AMP-binding enzyme family protein 0.0007 0.0086 0.0586
Giardia lamblia Reductase, putative 0.0004 0 0.5
Trichomonas vaginalis antibiotic synthetase, putative 0.0007 0.0086 0.1021
Echinococcus granulosus mixed lineage leukemia protein mll 0.0007 0.0081 0.0081
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.1403 0.1403
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0614 0.4179
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.0086 0.0115
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0065 0.0775
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0007 0.0086 0.0115
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0341 0.0457
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0843 1
Brugia malayi beta-lactamase family protein 0.0038 0.0843 0.5741
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0065 0.0775
Schistosoma mansoni tar DNA-binding protein 0.0063 0.1468 0.1468
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0007 0.0086 0.0115
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0522 0.3723
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0843 1
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0025 0.0522 0.07
Brugia malayi beta-lactamase 0.0038 0.0843 0.5741
Plasmodium vivax acyl-CoA synthetase, putative 0.0019 0.0366 0.0491
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0007 0.0081 0.0081
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0007 0.0086 0.0115
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0843 0.0843
Echinococcus multilocularis beta LACTamase domain containing family member 0.0038 0.0843 0.0843
Onchocerca volvulus 0.0029 0.0614 0.7279
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0025 0.0522 0.07
Mycobacterium tuberculosis Probable esterase LipL 0.0038 0.0843 0.1129
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.1403 0.1403
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0063 0.1468 1
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0065 0.0775
Loa Loa (eye worm) hypothetical protein 0.0038 0.0843 0.5741
Brugia malayi AMP-binding enzyme family protein 0.0007 0.0086 0.0586
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0007 0.0086 0.0586
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0007 0.0081 0.0081
Mycobacterium tuberculosis 3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III) 0.0306 0.7462 1
Brugia malayi AMP-binding enzyme family protein 0.0007 0.0086 0.0586
Loa Loa (eye worm) hypothetical protein 0.0007 0.0086 0.0586
Leishmania major acetyl-CoA synthetase, putative 0.0007 0.0086 0.0613
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0007 0.0086 0.0586
Mycobacterium ulcerans acyl-CoA synthetase 0.0007 0.0086 0.0115
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0007 0.0086 0.1021
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0007 0.0086 0.1021
Mycobacterium tuberculosis Probable hydrolase 0.0038 0.0843 0.1129
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.1403 0.1881
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.1408 0.1408
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0007 0.0086 0.0115
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0038 0.0843 0.1129
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0065 0.0775
Trichomonas vaginalis antibiotic synthetase, putative 0.0007 0.0086 0.1021
Onchocerca volvulus 0.0007 0.0086 0.1021
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0025 0.0522 0.07
Echinococcus granulosus tar DNA binding protein 0.0063 0.1468 0.1468
Loa Loa (eye worm) hypothetical protein 0.0038 0.0843 0.5741
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0007 0.0086 0.1021
Schistosoma mansoni tar DNA-binding protein 0.0063 0.1468 0.1468
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0007 0.0086 0.0115
Schistosoma mansoni hypothetical protein 0.0409 1 1
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0843 1
Schistosoma mansoni cpg binding protein 0.003 0.0654 0.0654
Loa Loa (eye worm) hypothetical protein 0.0025 0.0522 0.3558
Trichomonas vaginalis helicase, putative 0.0007 0.0065 0.0775
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0522 0.3558
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0007 0.0086 0.0115
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.0086 0.0115
Schistosoma mansoni tar DNA-binding protein 0.0063 0.1468 0.1468
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0341 0.0457
Mycobacterium ulcerans acyl-CoA synthetase 0.0007 0.0086 0.0115
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0025 0.0522 0.07
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0007 0.0086 0.0613
Mycobacterium ulcerans acyl-CoA synthetase 0.0007 0.0086 0.0115
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0007 0.0086 0.0115
Echinococcus multilocularis dnaJ subfamily B 0.0409 1 1
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.0086 0.0115
Schistosoma mansoni cpg binding protein 0.0029 0.0614 0.0614
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0025 0.0522 0.07
Giardia lamblia Hypothetical protein 0.0004 0 0.5
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0522 0.3723
Plasmodium falciparum beta-ketoacyl-ACP synthase III 0.0306 0.7462 1
Mycobacterium tuberculosis Probable lipase LipD 0.0038 0.0843 0.1129
Brugia malayi CXXC zinc finger family protein 0.0029 0.0614 0.4179
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0065 0.0775
Loa Loa (eye worm) hypothetical protein 0.0019 0.0366 0.2495
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0007 0.0086 0.0586
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0124 0.0124
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0019 0.0366 0.0491
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0065 0.0775
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0007 0.0086 0.1021
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0843 1
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0007 0.0081 0.0081
Trypanosoma brucei hypothetical protein, conserved 0.0038 0.0843 1
Mycobacterium leprae conserved hypothetical protein 0.0038 0.0843 1
Entamoeba histolytica fatty acid elongase, putative 0.004 0.0886 1
Brugia malayi TAR-binding protein 0.0063 0.1468 1
Chlamydia trachomatis oxoacyl-ACP synthase III 0.0306 0.7462 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0522 0.3558
Echinococcus multilocularis tar DNA binding protein 0.0063 0.1468 0.1468
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0007 0.0086 0.0971
Loa Loa (eye worm) hypothetical protein 0.0019 0.0366 0.2495
Loa Loa (eye worm) oxidoreductase 0.0007 0.0086 0.0586
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0843 1
Onchocerca volvulus 0.0007 0.0086 0.1021

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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