Detailed information for compound 572692

Basic information

Technical information
  • TDR Targets ID: 572692
  • Name: 7-chloro-3-(4-methylpiperazin-1-yl)-4H-benzo[ e][1,2,4]thiadiazine 1,1-dioxide
  • MW: 314.791 | Formula: C12H15ClN4O2S
  • H donors: 1 H acceptors: 2 LogP: 0.83 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN1CCN(CC1)C1=NS(=O)(=O)c2c(N1)ccc(c2)Cl
  • InChi: 1S/C12H15ClN4O2S/c1-16-4-6-17(7-5-16)12-14-10-3-2-9(13)8-11(10)20(18,19)15-12/h2-3,8H,4-7H2,1H3,(H,14,15)
  • InChiKey: JPZVJONKWYICFB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 7-chloro-3-(4-methyl-1-piperazinyl)-4H-benzo[e][1,2,4]thiadiazine 1,1-dioxide
  • 7-chloro-3-(4-methylpiperazino)-4H-benzo[e][1,2,4]thiadiazine 1,1-dioxide
  • DU 717
  • 59943-31-6
  • NSC292806
  • 7-Chloro-3-(4-methyl-1-piperazinyl)-4H-1,2,4-benzothiadiazine 1,1-dioxide
  • 2H-1,2,4-BENZOTHIADIAZINE, 7-CHLORO-3-(4-METHYL-1-PIPERAZINYL)-, 1,1-DIOXIDE
  • 7-Chloro-3-(4-methyl-1-piperazinyl)-2H-1,2,4-benzothiadiazine-1,1-dioxide
  • 7-Chloro-3-(4-methyl-1-piperazinyl)-4H-1,2,4-benzothiadiazine-1,1-dioxide
  • DU-717
  • NSC 292806

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica hypothetical protein 0.0004 0.0011 0.0066
Entamoeba histolytica hypothetical protein 0.0004 0.0005 0.0033
Echinococcus granulosus muscleblind protein 0.0145 0.2578 0.5126
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0036 0.0593 0.3668
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0004 0.0013 0.0026
Entamoeba histolytica tyrosine kinase, putative 0.0004 0.0005 0.0033
Echinococcus granulosus mixed lineage leukemia protein mll 0.0007 0.0066 0.0121
Echinococcus multilocularis sodium and chloride dependent glycine 0.0048 0.0803 0.159
Echinococcus multilocularis serotonin transporter 0.028 0.5025 1
Schistosoma mansoni serine/threonine protein kinase 0.0092 0.1608 0.3201
Entamoeba histolytica hypothetical protein 0.0011 0.0146 0.0905
Entamoeba histolytica protein kinase domain containing protein 0.0004 0.0011 0.0066
Toxoplasma gondii hypothetical protein 0.0048 0.0803 0.8901
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0097 0.0183
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0055 0.0331
Entamoeba histolytica tyrosine kinase, putative 0.0004 0.0011 0.0066
Entamoeba histolytica cysteine surface protein, putative 0.0004 0.0005 0.0033
Schistosoma mansoni apoferritin-2 0.0008 0.009 0.0179
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.0748 0.0967
Echinococcus multilocularis ferritin 0.0008 0.009 0.0169
Entamoeba histolytica protein kinase, putative 0.0004 0.0005 0.0033
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0593 0.0594
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0055 0.0331
Loa Loa (eye worm) hypothetical protein 0.0004 0.0012 0.0009
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0055 0.0331
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0036 0.0593 0.1171
Echinococcus granulosus geminin 0.0165 0.2933 0.5832
Entamoeba histolytica tyrosine kinase, putative 0.0004 0.0011 0.0066
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0748 0.1488
Schistosoma mansoni sodium/chloride dependent transporter 0.0048 0.0803 0.1599
Plasmodium falciparum amino acid transporter, putative 0.0048 0.0803 1
Trichomonas vaginalis conserved hypothetical protein 0.0004 0.0005 0.0021
Entamoeba histolytica tyrosine kinase, putative 0.0004 0.0011 0.0066
Schistosoma mansoni ferritin light chain 0.0008 0.009 0.0179
Echinococcus granulosus kelch ECH associated protein 1 like 0.0092 0.1608 0.3193
Entamoeba histolytica tumor susceptibility gene 101 protein, putative 0.0046 0.0776 0.4822
Entamoeba histolytica hypothetical protein 0.0011 0.0146 0.0905
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0011 0.0146 0.0183
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0748 0.148
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0048 0.0803 0.159
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0007 0.0066 0.0132
Entamoeba histolytica hypothetical protein 0.0035 0.0576 0.3578
Mycobacterium ulcerans UDP-galactopyranose mutase Glf 0.0554 1 1
Echinococcus granulosus kelch ECH associated protein 1 like 0.0092 0.1608 0.3193
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.0593 0.3681
Loa Loa (eye worm) hypothetical protein 0.028 0.5025 0.6537
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0048 0.0803 0.8901
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.1608 1
Entamoeba histolytica tyrosine kinase, putative 0.0004 0.0011 0.0066
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0011 0.0146 0.0183
Trypanosoma cruzi polo-like protein kinase, putative 0.0092 0.1608 0.2088
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0055 0.0331
Schistosoma mansoni ferritin 0.0008 0.009 0.0179
Entamoeba histolytica pro protein convertase subtilisin/kexinType 5 precursor, putative 0.0004 0.0005 0.0033
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0011 0.0146 0.0183
Trypanosoma cruzi hypothetical protein, conserved 0.0011 0.0146 0.0183
Schistosoma mansoni tsg101-related 0.0046 0.0776 0.1543
Brugia malayi CXXC zinc finger family protein 0.0028 0.0447 0.0576
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0048 0.0803 0.159
Loa Loa (eye worm) hypothetical protein 0.028 0.5025 0.6537
Treponema pallidum sodium- and chloride- dependent transporter 0.028 0.5025 1
Loa Loa (eye worm) hypothetical protein 0.0048 0.0803 0.1039
Loa Loa (eye worm) hypothetical protein 0.0048 0.0803 0.1039
Echinococcus multilocularis expressed protein 0.0008 0.009 0.0169
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0011 0.0146 0.0183
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0048 0.0803 0.1599
Entamoeba histolytica protein kinase, putative 0.0004 0.0011 0.0066
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0011 0.0146 0.0183
Schistosoma mansoni ferritin light chain 0.0008 0.009 0.0179
Onchocerca volvulus 0.0028 0.0447 0.0881
Loa Loa (eye worm) hypothetical protein 0.0218 0.3898 0.507
Loa Loa (eye worm) hypothetical protein 0.0068 0.1168 0.1515
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0048 0.0803 0.159
Brugia malayi all-trans-13,14-dihydroretinol saturase 0.0004 0.0012 0.0009
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0593 0.0766
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0055 0.0331
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0008 0.009 0.0078
Entamoeba histolytica tyrosine kinase, putative 0.0004 0.0011 0.0066
Onchocerca volvulus 0.0004 0.0012 0.0014
Schistosoma mansoni sodium/chloride dependent transporter 0.0048 0.0809 0.1609
Schistosoma mansoni tsg101-related 0.0056 0.0963 0.1916
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0092 0.1608 0.2088
Loa Loa (eye worm) hypothetical protein 0.0036 0.0593 0.0766
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0006 0.0055 0.0331
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0011 0.0146 0.0183
Plasmodium falciparum transporter, putative 0.0048 0.0803 1
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0011 0.0146 0.0183
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0055 0.0331
Echinococcus multilocularis cpg binding protein 0.003 0.0476 0.0938
Brugia malayi hypothetical protein 0.0068 0.1168 0.1515
Entamoeba histolytica tyrosine kinase, putative 0.0004 0.0011 0.0066
Schistosoma mansoni cpg binding protein 0.003 0.0476 0.0948
Entamoeba histolytica tyrosine kinase, putative 0.0004 0.0011 0.0066
Schistosoma mansoni kinase 0.0047 0.0788 0.1568
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0748 0.148
Toxoplasma gondii hypothetical protein 0.0048 0.0803 0.8901
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0036 0.0593 0.1171
Onchocerca volvulus 0.028 0.5025 1
Entamoeba histolytica tyrosine kinase, putative 0.0004 0.0005 0.0033
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0048 0.0803 0.8901
Entamoeba histolytica serine/threonine protein kinase, putative 0.0092 0.1608 1
Onchocerca volvulus 0.0004 0.0012 0.0014
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0048 0.0803 0.1599
Schistosoma mansoni sodium/chloride dependent transporter 0.028 0.5025 1
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0048 0.0803 0.1599
Entamoeba histolytica hypothetical protein 0.0011 0.0146 0.0905
Brugia malayi serine/threonine-protein kinase plk-2 0.0092 0.1608 0.2088
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0092 0.1608 0.3193
Schistosoma mansoni amine oxidase 0.0004 0.0012 0.0024
Entamoeba histolytica protein kinase, putative 0.0004 0.0011 0.0066
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.028 0.5025 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0055 0.0331
Leishmania major hypothetical protein, conserved 0.0022 0.0333 0.0427
Entamoeba histolytica tyrosine kinase, putative 0.0004 0.0005 0.0033
Trypanosoma cruzi hypothetical protein, conserved 0.0011 0.0146 0.0183
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0007 0.0066 0.0121
Entamoeba histolytica tyrosine kinase, putative 0.0004 0.0005 0.0033
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0427 0.7684 1
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0048 0.0803 0.1039
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0055 0.0331
Echinococcus granulosus expressed protein 0.0008 0.009 0.0169
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0146 0.0895
Loa Loa (eye worm) hypothetical protein 0.0048 0.0803 0.1039
Mycobacterium tuberculosis UDP-galactopyranose mutase Glf (UDP-GALP mutase) (NAD+-flavin adenine dinucleotide-requiring enzyme) 0.0554 1 1
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0092 0.1608 0.2088
Loa Loa (eye worm) hypothetical protein 0.0004 0.0012 0.0009
Entamoeba histolytica tyrosine kinase, putative 0.0004 0.0005 0.0033
Schistosoma mansoni tsg101-related 0.0056 0.0963 0.1916
Entamoeba histolytica tyrosine kinase, putative 0.0004 0.0011 0.0066
Trypanosoma brucei beta lactamase 0.0062 0.1065 0.122
Trichomonas vaginalis ferritin, putative 0.0008 0.009 0.0548
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0048 0.0803 0.159
Schistosoma mansoni apoferritin-2 0.0008 0.009 0.0179
Mycobacterium tuberculosis Probable conserved lipoprotein LpqF 0.0062 0.1065 0.1054
Echinococcus multilocularis kelch ECH associated protein 1 0.0092 0.1608 0.3193
Mycobacterium tuberculosis Class a beta-lactamase BlaC 0.0129 0.2284 0.2274
Brugia malayi Sodium:neurotransmitter symporter family protein 0.028 0.5025 0.6537
Loa Loa (eye worm) hypothetical protein 0.0048 0.0803 0.1039
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0048 0.0803 0.1599
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0036 0.0593 0.1181
Loa Loa (eye worm) hypothetical protein 0.0048 0.0803 0.1039
Trichomonas vaginalis CAMK family protein kinase 0.0045 0.0766 0.4756
Mycobacterium ulcerans class a beta-lactamase, BlaC 0.0129 0.2284 0.2274
Loa Loa (eye worm) hypothetical protein 0.0427 0.7684 1
Schistosoma mansoni ferritin 0.0008 0.009 0.0179
Trichomonas vaginalis conserved hypothetical protein 0.0004 0.0005 0.0021
Entamoeba histolytica tyrosine kinase, putative 0.0004 0.0011 0.0066
Trichomonas vaginalis Involucrin, putative 0.0004 0.0005 0.0021
Echinococcus granulosus tumor susceptibility gene 101 protein 0.0068 0.1168 0.2317
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0092 0.1608 0.3193
Entamoeba histolytica protein kinase, putative 0.0004 0.0011 0.0066
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.1608 1
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0004 0.0012 0.0152
Loa Loa (eye worm) lethal protein 721 0.0004 0.0012 0.0009
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0055 0.0331
Mycobacterium ulcerans bacterioferritin BfrB 0.0008 0.009 0.0078
Entamoeba histolytica cysteine surface protein, putative 0.0004 0.0005 0.0033
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0007 0.0066 0.0121
Entamoeba histolytica hypothetical protein 0.0004 0.0005 0.0033
Onchocerca volvulus 0.0048 0.0803 0.159
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0007 0.0066 0.0121
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0048 0.0803 0.159
Entamoeba histolytica cysteine surface protein, putative 0.0004 0.0005 0.0033
Entamoeba histolytica tyrosine kinase, putative 0.0004 0.0011 0.0066
Trypanosoma cruzi polo-like protein kinase, putative 0.0092 0.1608 0.2088
Entamoeba histolytica protein kinase domain containing protein 0.0004 0.0011 0.0066
Entamoeba histolytica protein kinase domain containing protein 0.0004 0.0011 0.0066
Brugia malayi hypothetical protein 0.0035 0.0576 0.0743
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0011 0.0146 0.0183
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0036 0.0593 0.0766
Trypanosoma cruzi Vps23 core domain containing protein, putative 0.0022 0.0333 0.0427
Schistosoma mansoni hypothetical protein 0.0165 0.2933 0.5836
Echinococcus granulosus ferritin 0.0008 0.009 0.0169
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0048 0.0803 0.1599
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0048 0.0803 0.1039
Echinococcus multilocularis geminin 0.0165 0.2933 0.5832
Entamoeba histolytica protein kinase, putative 0.0004 0.0011 0.0066
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0008 0.009 0.0078
Mycobacterium ulcerans lipoprotein LpqF 0.0062 0.1065 0.1054
Entamoeba histolytica tyrosine kinase, putative 0.0004 0.0005 0.0033
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0048 0.0803 0.1599
Loa Loa (eye worm) hypothetical protein 0.028 0.5025 0.6537
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.1608 1
Schistosoma mansoni hypothetical protein 0.0004 0.0012 0.0024
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.0593 0.3681
Trichomonas vaginalis DNA double-strand break repair Rad50 ATPase, putative 0.0004 0.0005 0.0021
Brugia malayi hypothetical protein 0.0048 0.0803 0.1039
Onchocerca volvulus Serine\/threonine kinase homolog 0.0092 0.1608 0.3193
Giardia lamblia Kinase, PLK 0.0092 0.1608 1
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0006 0.0043 0.0348
Leishmania major C-8 sterol isomerase-like protein 0.0427 0.7684 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0055 0.0331
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0427 0.7684 1
Entamoeba histolytica cysteine surface protein, putative 0.0004 0.0005 0.0033
Loa Loa (eye worm) serotonin transporter b 0.028 0.5025 0.6537
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0748 0.148
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0748 0.148
Mycobacterium ulcerans bacterioferritin BfrA 0.0008 0.009 0.0078
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0576 0.1145
Echinococcus multilocularis sodium and chloride dependent glycine 0.0048 0.0803 0.159
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0036 0.0593 0.1171
Echinococcus multilocularis ubiquitin specific protease 41 0.0036 0.0593 0.1171
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0055 0.0331
Echinococcus granulosus prenylcysteine oxidase 0.0004 0.0012 0.0014
Schistosoma mansoni notch 0.0004 0.0005 0.001
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0095 0.0117
Schistosoma mansoni ferritin 0.0008 0.009 0.0179
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0059 0.1016 0.2022
Echinococcus multilocularis Kelch repeat type 1 0.0092 0.1613 0.3202
Leishmania major electron transfer flavoprotein-ubiquinone oxidoreductase, putative 0.0004 0.0012 0.0009
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0593 0.3681
Schistosoma mansoni hypothetical protein 0.0092 0.1613 0.3209
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0036 0.0593 0.1181
Echinococcus multilocularis muscleblind protein 1 0.0145 0.2578 0.5126
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.1608 1
Entamoeba histolytica protein kinase, putative 0.0004 0.0011 0.0066
Echinococcus multilocularis prenylcysteine oxidase 0.0004 0.0012 0.0014
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0036 0.0593 0.3688
Echinococcus granulosus ubiquitin specific protease 41 0.0036 0.0593 0.1171
Mycobacterium leprae PROBABLE CONSERVED LIPOPROTEIN LPQF 0.0062 0.1065 0.1054
Entamoeba histolytica tyrosine kinase, putative 0.0004 0.0011 0.0066
Entamoeba histolytica tyrosine kinase, putative 0.0004 0.0011 0.0066
Loa Loa (eye worm) hypothetical protein 0.0145 0.2578 0.3351
Entamoeba histolytica tyrosine kinase, putative 0.0004 0.0011 0.0066
Entamoeba histolytica tyrosine kinase, putative 0.0004 0.0005 0.0033
Brugia malayi Muscleblind-like protein 0.0145 0.2578 0.3351
Toxoplasma gondii histone lysine methyltransferase SET1 0.0053 0.0901 1
Entamoeba histolytica hypothetical protein 0.0035 0.0576 0.3578
Echinococcus granulosus serotonin transporter 0.028 0.5025 1
Trypanosoma cruzi electron transfer flavoprotein-ubiquinone oxidoreductase, putative 0.0004 0.0012 0.0009
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0008 0.009 0.5
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0048 0.0803 0.1599
Entamoeba histolytica protein kinase domain containing protein 0.0004 0.0011 0.0066
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0447 0.0576
Onchocerca volvulus 0.0048 0.0803 0.159
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0146 0.0895
Plasmodium vivax hypothetical protein, conserved 0.0048 0.0803 1
Schistosoma mansoni ferritin 0.0008 0.009 0.0179
Entamoeba histolytica protein kinase, putative 0.0004 0.0011 0.0066
Entamoeba histolytica hypothetical protein 0.0035 0.0576 0.3578
Entamoeba histolytica protein kinase, putative 0.0004 0.0011 0.0066
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0748 0.1488
Entamoeba histolytica tyrosine kinase, putative 0.0004 0.0011 0.0066
Entamoeba histolytica hypothetical protein 0.0004 0.0011 0.0066
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0048 0.0803 0.1039
Trypanosoma cruzi UDP-galactopyranose mutase 0.0004 0.0012 0.0009
Entamoeba histolytica hypothetical protein 0.0004 0.0005 0.0033
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0055 0.0331
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0055 0.0331
Entamoeba histolytica hypothetical protein 0.0004 0.0011 0.0066
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0011 0.0146 0.0183
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0011 0.0146 0.0183
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0576 0.1136
Entamoeba histolytica tyrosine kinase, putative 0.0004 0.0011 0.0066
Echinococcus granulosus kelch ECH associated protein 1 0.0092 0.1608 0.3193
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0048 0.0803 0.1039
Entamoeba histolytica tyrosine kinase, putative 0.0004 0.0011 0.0066
Echinococcus granulosus protoporphyrinogen oxidase 0.0004 0.0012 0.0014
Trypanosoma brucei Vps23 core domain containing protein, putative 0.0022 0.0333 0.0248
Entamoeba histolytica tyrosine kinase, putative 0.0004 0.0005 0.0033
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0593 0.0766
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0048 0.0803 0.159
Trichomonas vaginalis helicase, putative 0.0006 0.0055 0.0331
Entamoeba histolytica hypothetical protein 0.0004 0.0005 0.0033
Entamoeba histolytica hypothetical protein, conserved 0.0004 0.0005 0.0033
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0048 0.0803 0.5
Entamoeba histolytica protein kinase domain containing protein 0.0004 0.0011 0.0066
Trypanosoma brucei polo-like protein kinase 0.0092 0.1608 0.194
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0048 0.0803 0.1039
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0097 0.0183
Entamoeba histolytica hypothetical protein 0.0004 0.0005 0.0033
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0048 0.0803 0.8901
Entamoeba histolytica tyrosine kinase, putative 0.0004 0.0011 0.0066
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0055 0.0331
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0048 0.0803 0.1039
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.1608 1
Echinococcus granulosus sodium and chloride dependent glycine 0.0048 0.0803 0.159
Plasmodium vivax amine transporter, putative 0.0048 0.0803 1
Echinococcus granulosus sodium and chloride dependent glycine 0.0048 0.0803 0.159
Schistosoma mansoni hypothetical protein 0.0165 0.2933 0.5836
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0748 0.1488
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.1608 1
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.1608 1
Loa Loa (eye worm) solute carrier family 6 member 4 0.028 0.5025 0.6537
Entamoeba histolytica tyrosine kinase, putative 0.0004 0.0005 0.0033
Trichomonas vaginalis CAMK family protein kinase 0.0045 0.0766 0.4756
Entamoeba histolytica protein kinase, putative 0.0004 0.0005 0.0033
Loa Loa (eye worm) hypothetical protein 0.0048 0.0803 0.1039
Onchocerca volvulus 0.0048 0.0803 0.159
Loa Loa (eye worm) hypothetical protein 0.0145 0.2578 0.3351
Schistosoma mansoni hypothetical protein 0.0035 0.0576 0.1145
Entamoeba histolytica protein kinase domain containing protein 0.0004 0.0011 0.0066
Schistosoma mansoni cpg binding protein 0.003 0.0476 0.0948
Schistosoma mansoni cpg binding protein 0.0028 0.0447 0.089
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0576 0.1136
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.0748 0.0967
Entamoeba histolytica protein kinase domain containing protein 0.0004 0.0011 0.0066
Loa Loa (eye worm) hypothetical protein 0.0048 0.0803 0.1039
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0097 0.012
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0048 0.0803 0.1599
Echinococcus multilocularis tumor susceptibility gene 101 protein 0.0068 0.1168 0.2317
Echinococcus multilocularis kelch ECH associated protein 1 0.0092 0.1608 0.3193
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0036 0.0593 0.1171
Entamoeba histolytica protein kinase, putative 0.0004 0.0011 0.0066
Echinococcus granulosus cpg binding protein 0.003 0.0476 0.0938
Entamoeba histolytica tyrosine kinase, putative 0.0004 0.0005 0.0033
Loa Loa (eye worm) norepinephrine transporter 0.028 0.5025 0.6537
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0036 0.0593 0.0766
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0055 0.0331
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0008 0.009 0.0078
Trypanosoma cruzi electron transfer flavoprotein-ubiquinone oxidoreductase, putative 0.0004 0.0012 0.0009
Schistosoma mansoni sodium-dependent amino acid transporter 0.0048 0.0803 0.1599
Entamoeba histolytica CXXC-rich protein 0.0004 0.0005 0.0033
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0011 0.0146 0.0183
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0048 0.0803 0.159
Trypanosoma brucei C-8 sterol isomerase, putative 0.0427 0.7684 1
Entamoeba histolytica hypothetical protein 0.0011 0.0146 0.0905
Trichomonas vaginalis hypothetical protein 0.0033 0.0538 0.334
Entamoeba histolytica hypothetical protein 0.0035 0.0576 0.3578
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0006 0.0055 0.0331
Echinococcus multilocularis muscleblind protein 0.0145 0.2578 0.5126

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.