Detailed information for compound 580537

Basic information

Technical information
  • TDR Targets ID: 580537
  • Name: 1,3-dichloro-5-(4-isopropylphenyl)benzene
  • MW: 265.178 | Formula: C15H14Cl2
  • H donors: 0 H acceptors: 0 LogP: 5.93 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(c1ccc(cc1)c1cc(Cl)cc(c1)Cl)C
  • InChi: 1S/C15H14Cl2/c1-10(2)11-3-5-12(6-4-11)13-7-14(16)9-15(17)8-13/h3-10H,1-2H3
  • InChiKey: AXXUAYWMQQEWQC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1,3-dichloro-5-(4-propan-2-ylphenyl)benzene
  • 1,3-dichloro-5-p-cumenyl-benzene
  • 3,5-dichloro-4'-isopropylbiphenyl
  • 74338-50-4
  • 1,1'-Biphenyl, 3,5-dichloro-4'-isopropyl
  • 1,1'-Biphenyl, 3,5-dichloro-4'-(1-methylethyl)-

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0023 0.0018 0.0021
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0052 0.0607 0.1022
Trichomonas vaginalis PIKK family atypical protein kinase 0.0104 0.1668 0.1652
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0321 0.6082 0.6075
Loa Loa (eye worm) hypothetical protein 0.004 0.0357 0.0389
Trichomonas vaginalis PIKK family atypical protein kinase 0.0132 0.223 0.2216
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0049 0.0548 0.0609
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0152 0.2643 0.4329
Trichomonas vaginalis PIKK family atypical protein kinase 0.0129 0.2178 0.2164
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0357 0.065
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0152 0.2643 0.4797
Trichomonas vaginalis PIKK family atypical protein kinase 0.0142 0.2436 0.2423
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0038 0.0328 0.0311
Trichomonas vaginalis PIKK family atypical protein kinase 0.0129 0.2178 0.2164
Brugia malayi beta-lactamase family protein 0.004 0.0357 0.0409
Trichomonas vaginalis esterase, putative 0.004 0.0357 0.034
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.014 0.014
Schistosoma mansoni jumonji/arid domain-containing protein 0.0073 0.1029 0.1875
Loa Loa (eye worm) hypothetical protein 0.004 0.0357 0.0389
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.006 0.0773 0.1407
Loa Loa (eye worm) intermediate filament protein 0.0029 0.014 0.014
Trichomonas vaginalis PIKK family atypical protein kinase 0.0139 0.2384 0.237
Trichomonas vaginalis PIKK family atypical protein kinase 0.0156 0.2722 0.2709
Leishmania major phosphatidylinositol 3-kinase, putative 0.0119 0.1971 0.7223
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.006 0.0772 0.1308
Loa Loa (eye worm) hypothetical protein 0.0103 0.1644 0.1866
Echinococcus multilocularis serine protein kinase ATM 0.0083 0.1246 0.2131
Loa Loa (eye worm) hypothetical protein 0.0067 0.0917 0.1031
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0607 0.059
Trypanosoma brucei hypothetical protein, conserved 0.004 0.0357 0.1254
Trichomonas vaginalis PIKK family atypical protein kinase 0.0152 0.2643 0.263
Trichomonas vaginalis PIKK family atypical protein kinase 0.0152 0.2643 0.263
Brugia malayi beta-lactamase family protein 0.004 0.0357 0.0409
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0083 0.1246 0.1427
Trichomonas vaginalis PIKK family atypical protein kinase 0.0087 0.133 0.1314
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.004 0.0357 0.0409
Trichomonas vaginalis PIKK family atypical protein kinase 0.0129 0.2177 0.2163
Echinococcus granulosus jumonji domain containing protein 0.0084 0.125 0.2138
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0152 0.2643 0.9709
Toxoplasma gondii ABC1 family protein 0.004 0.0357 0.1433
Schistosoma mansoni serine/threonine protein kinase 0.0185 0.3318 0.6044
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0041 0.0383 0.0439
Giardia lamblia Fructose-bisphosphate aldolase 0.0321 0.6082 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0548 0.092
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0067 0.0917 0.1559
Echinococcus granulosus serine protein kinase ATM 0.0083 0.1246 0.2131
Leishmania major phosphatidylinositol kinase related protein, putative 0.0039 0.0348 0.1218
Echinococcus multilocularis lamin dm0 0.0029 0.014 0.0211
Schistosoma mansoni hypothetical protein 0.0042 0.0407 0.0742
Mycobacterium leprae Probable lipase LipE 0.004 0.0357 0.1244
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0772 0.1739
Trichomonas vaginalis PIKK family atypical protein kinase 0.0119 0.1971 0.1957
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0292 0.549 1
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0041 0.0383 0.0633
Loa Loa (eye worm) hypothetical protein 0.0135 0.229 0.2607
Brugia malayi jmjC domain containing protein 0.0197 0.3548 0.4063
Trichomonas vaginalis PIKK family atypical protein kinase 0.0152 0.2643 0.263
Trichomonas vaginalis PIKK family atypical protein kinase 0.0087 0.133 0.1314
Echinococcus granulosus peregrin 0.006 0.0773 0.1309
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0083 0.1246 0.227
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.006 0.0781 0.1394
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0321 0.6082 0.6075
Loa Loa (eye worm) hypothetical protein 0.0065 0.0869 0.0977
Trichomonas vaginalis PIKK family atypical protein kinase 0.0142 0.2436 0.2423
Echinococcus granulosus histone lysine methyltransferase setb 0.0065 0.0869 0.1477
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0307 0.5781 1
Leishmania major hypothetical protein, conserved 0.004 0.0357 0.1254
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0548 0.0999
Loa Loa (eye worm) hypothetical protein 0.006 0.0781 0.0875
Onchocerca volvulus Alhambra homolog 0.006 0.0773 0.0756
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0065 0.0869 0.3598
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0023 0.0018 0.0021
Onchocerca volvulus Huntingtin homolog 0.0135 0.229 0.2276
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0023 0.0018 0.0021
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0039 0.0348 0.0602
Trichomonas vaginalis PIKK family atypical protein kinase 0.0139 0.2384 0.237
Trichomonas vaginalis PIKK family atypical protein kinase 0.0087 0.133 0.1314
Trypanosoma cruzi hypothetical protein, conserved 0.0101 0.1596 0.2883
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.004 0.0357 0.0389
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0023 0.0018 0.0033
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0083 0.1246 0.2244
Trichomonas vaginalis PIKK family atypical protein kinase 0.0139 0.2384 0.237
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0152 0.2643 0.4329
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0023 0.0018 0.0033
Mycobacterium tuberculosis Probable conserved lipoprotein 0.004 0.0357 0.0725
Plasmodium vivax hypothetical protein, conserved 0.004 0.0357 0.3982
Plasmodium falciparum phd finger protein, putative 0.006 0.0773 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0098 0.1538 0.1522
Loa Loa (eye worm) hypothetical protein 0.004 0.0357 0.0389
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0142 0.2437 0.8947
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0321 0.6082 0.6075
Plasmodium vivax SET domain protein, putative 0.0065 0.0869 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0067 0.0917 0.105
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0023 0.0018 0.0033
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0452 0.8732 1
Loa Loa (eye worm) hypothetical protein 0.006 0.0773 0.0866
Echinococcus granulosus lamin 0.0029 0.014 0.0211
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.006 0.0772 0.1613
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0152 0.2643 0.9709
Trichomonas vaginalis PIKK family atypical protein kinase 0.0142 0.2436 0.2423
Echinococcus multilocularis PHD finger protein rhinoceros 0.006 0.0773 0.1309
Echinococcus multilocularis lamin 0.0029 0.014 0.0211
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0321 0.6082 0.6075
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0023 0.0018 0.0021
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.006 0.0772 0.1308
Trichomonas vaginalis PIKK family atypical protein kinase 0.009 0.1382 0.1366
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0023 0.0018 0.0021
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0548 0.092
Trichomonas vaginalis PIKK family atypical protein kinase 0.0139 0.2384 0.237
Trichomonas vaginalis PIKK family atypical protein kinase 0.0129 0.2178 0.2164
Entamoeba histolytica hypothetical protein 0.0042 0.0407 0.0641
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0452 0.0434
Schistosoma mansoni hypothetical protein 0.0023 0.0018 0.0033
Echinococcus multilocularis peregrin 0.006 0.0773 0.1309
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0357 0.0619
Mycobacterium tuberculosis Conserved protein 0.004 0.0357 0.0725
Entamoeba histolytica hypothetical protein 0.0042 0.0407 0.0641
Echinococcus multilocularis jumonji domain containing protein 0.0084 0.125 0.2138
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0357 0.0619
Mycobacterium tuberculosis Probable esterase LipL 0.004 0.0357 0.0725
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0292 0.549 1
Schistosoma mansoni voltage-gated potassium channel 0.0045 0.0459 0.0836
Schistosoma mansoni lamin 0.0029 0.014 0.0255
Echinococcus multilocularis musashi 0.0029 0.014 0.0211
Loa Loa (eye worm) jmjC domain-containing protein 0.0124 0.2072 0.2356
Loa Loa (eye worm) CAMK/CAMKL/CHK1 protein kinase 0.0185 0.3318 0.3787
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0041 0.0383 0.0633
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0224 0.0206
Loa Loa (eye worm) hypothetical protein 0.0052 0.0607 0.0676
Echinococcus granulosus lysine specific demethylase 5A 0.0073 0.1029 0.1755
Giardia lamblia PHD finger protein 15 0.006 0.0773 0.1244
Echinococcus multilocularis lysine specific demethylase 5A 0.0073 0.1029 0.1755
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0023 0.0018 0.0033
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0321 0.6082 0.6075
Echinococcus multilocularis beta LACTamase domain containing family member 0.004 0.0357 0.0588
Treponema pallidum fructose-bisphosphate aldolase 0.0321 0.6082 0.5
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0357 0.034
Mycobacterium tuberculosis Conserved protein 0.004 0.0357 0.0725
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0292 0.549 0.6288
Brugia malayi FAT domain containing protein 0.0052 0.0607 0.0696
Trichomonas vaginalis PIKK family atypical protein kinase 0.01 0.1589 0.1574
Loa Loa (eye worm) hypothetical protein 0.0135 0.229 0.2607
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0321 0.6082 0.6075
Schistosoma mansoni hypothetical protein 0.006 0.0773 0.1407
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0065 0.0869 0.1584
Trichomonas vaginalis PIKK family atypical protein kinase 0.0119 0.1971 0.1957
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0065 0.0869 0.1584
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0152 0.2643 0.4555
Brugia malayi PHD-finger family protein 0.006 0.0773 0.0885
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0156 0.2722 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0152 0.2643 0.3013
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0065 0.0869 0.1477
Onchocerca volvulus 0.0029 0.014 0.0122
Schistosoma mansoni jumonji/arid domain-containing protein 0.0073 0.1029 0.1875
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0152 0.2643 0.4555
Echinococcus granulosus beta LACTamase domain containing family member 0.004 0.0357 0.0588
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0152 0.2643 0.4797
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0023 0.0018 0.0033
Toxoplasma gondii target of rapamycin (TOR), putative 0.0139 0.2384 1
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0772 0.1406
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0197 0.3548 0.6125
Onchocerca volvulus 0.004 0.0357 0.034
Schistosoma mansoni jumonji domain containing protein 0.0156 0.2727 0.4967
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0152 0.2643 0.9709
Schistosoma mansoni fkbp-rapamycin associated protein 0.0067 0.0917 0.167
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0307 0.5781 1
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0067 0.0917 0.1642
Trichomonas vaginalis conserved hypothetical protein 0.0075 0.1073 0.1056
Loa Loa (eye worm) hypothetical protein 0.0029 0.014 0.014
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0357 0.034
Mycobacterium tuberculosis Probable lipase LipE 0.004 0.0357 0.0725
Trichomonas vaginalis set domain proteins, putative 0.0514 1 1
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0062 0.0821 0.1393
Schistosoma mansoni lamin 0.0029 0.014 0.0255
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0292 0.549 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0023 0.0018 0.0021
Loa Loa (eye worm) hypothetical protein 0.004 0.0357 0.0389
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0043 0.0431 0.1527
Schistosoma mansoni intermediate filament proteins 0.0029 0.014 0.0255
Schistosoma mansoni transcription factor LCR-F1 0.0042 0.0407 0.0742
Onchocerca volvulus 0.0065 0.0869 0.0853
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.004 0.0357 0.0725
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0083 0.1246 0.4542
Trichomonas vaginalis PIKK family atypical protein kinase 0.0129 0.2177 0.2163
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0052 0.0607 0.1022
Leishmania major hypothetical protein, conserved 0.0123 0.2061 0.7556
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0292 0.549 0.9496
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0548 0.0999
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0142 0.2437 0.8947
Echinococcus granulosus intermediate filament protein 0.0029 0.014 0.0211
Trichomonas vaginalis PIKK family atypical protein kinase 0.0129 0.2177 0.2163
Brugia malayi hypothetical protein 0.0042 0.0407 0.0466
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0023 0.0018 0.0021
Trichomonas vaginalis PIKK family atypical protein kinase 0.0067 0.0917 0.09
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0152 0.2643 0.4815
Plasmodium vivax hypothetical protein, conserved 0.006 0.0773 0.8863
Toxoplasma gondii PHD-finger domain-containing protein 0.006 0.0773 0.3189
Brugia malayi hypothetical protein 0.0135 0.229 0.2622
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0065 0.0869 0.1584
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0321 0.6082 0.6075
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0772 0.1406
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0067 0.0917 0.1559
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0065 0.0869 0.1477
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0152 0.2643 0.9709
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0292 0.549 0.9496
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0357 0.065
Loa Loa (eye worm) hypothetical protein 0.0035 0.0273 0.0293
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0075 0.1073 0.4457
Loa Loa (eye worm) hypothetical protein 0.0028 0.0129 0.0127
Brugia malayi Pre-SET motif family protein 0.0452 0.8732 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0304 0.0328
Trichomonas vaginalis PIKK family atypical protein kinase 0.0142 0.2436 0.2423
Entamoeba histolytica protein kinase rad3, putative 0.0067 0.0917 0.1482
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0357 0.034
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0321 0.6082 0.6075
Echinococcus granulosus lamin dm0 0.0029 0.014 0.0211
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0357 0.034
Brugia malayi Bromodomain containing protein 0.006 0.0773 0.0885
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0772 0.1739
Onchocerca volvulus 0.004 0.0357 0.034
Loa Loa (eye worm) phosphatidylinositol 3 0.0156 0.2722 0.3103
Trichomonas vaginalis PIKK family atypical protein kinase 0.0142 0.2436 0.2423
Brugia malayi intermediate filament protein 0.0029 0.014 0.016
Loa Loa (eye worm) PHD-finger family protein 0.006 0.0773 0.0866
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0042 0.0407 0.0675
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0023 0.0018 0.0033
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.004 0.0357 0.0725
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0357 0.034
Echinococcus granulosus PHD finger protein rhinoceros 0.006 0.0773 0.1309
Toxoplasma gondii PHD-finger domain-containing protein 0.006 0.0773 0.3189
Loa Loa (eye worm) hypothetical protein 0.0037 0.0304 0.0328
Loa Loa (eye worm) hypothetical protein 0.004 0.0357 0.0389
Loa Loa (eye worm) hypothetical protein 0.0075 0.1073 0.121
Trichomonas vaginalis PIKK family atypical protein kinase 0.0139 0.2384 0.237
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0104 0.1668 0.272
Giardia lamblia GTOR 0.0152 0.2643 0.4329
Schistosoma mansoni hypothetical protein 0.0052 0.0607 0.1106
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0049 0.0548 0.0628
Mycobacterium tuberculosis Probable lipase LipD 0.004 0.0357 0.0725
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0152 0.2643 0.3027
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0253 0.4691 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0548 0.0999
Trichomonas vaginalis PIKK family atypical protein kinase 0.0129 0.2178 0.2164
Trypanosoma cruzi target of rapamycin kinase 3 0.0142 0.2437 0.4421
Trichomonas vaginalis PIKK family atypical protein kinase 0.0119 0.1971 0.1957
Brugia malayi Protein kinase domain containing protein 0.0185 0.3318 0.38
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0085 0.128 0.4665
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0065 0.0869 0.1584
Trichomonas vaginalis PIKK family atypical protein kinase 0.0132 0.223 0.2216
Loa Loa (eye worm) jmjC domain-containing protein 0.0073 0.1029 0.116
Mycobacterium tuberculosis Conserved protein 0.004 0.0357 0.0725
Brugia malayi jmjC domain containing protein 0.0073 0.1029 0.1179
Loa Loa (eye worm) hypothetical protein 0.004 0.0357 0.0389
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0119 0.1971 0.7223
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0041 0.0383 0.0419
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0156 0.2722 1
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0157 0.2742 1
Mycobacterium tuberculosis Probable hydrolase 0.004 0.0357 0.0725
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0042 0.0407 0.0675
Onchocerca volvulus 0.004 0.0357 0.034
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0321 0.6082 1
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0023 0.0018 0.0033
Trichomonas vaginalis PIKK family atypical protein kinase 0.0139 0.2384 0.237
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0452 0.0434
Trichomonas vaginalis PIKK family atypical protein kinase 0.0119 0.1971 0.1957
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.006 0.0772 0.2787
Toxoplasma gondii FATC domain-containing protein 0.0083 0.1246 0.519
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0548 0.092
Onchocerca volvulus Huntingtin homolog 0.0135 0.229 0.2276
Mycobacterium leprae conserved hypothetical protein 0.004 0.0357 0.1244
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0321 0.6082 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0139 0.2384 0.237
Onchocerca volvulus 0.0029 0.014 0.0122
Entamoeba histolytica hypothetical protein 0.0042 0.0407 0.0641
Entamoeba histolytica hypothetical protein 0.0083 0.1246 0.2025
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0038 0.0328 0.0311
Trichomonas vaginalis PIKK family atypical protein kinase 0.0083 0.1246 0.123
Brugia malayi beta-lactamase 0.004 0.0357 0.0409
Loa Loa (eye worm) beta-lactamase 0.004 0.0357 0.0389
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0772 0.1739
Brugia malayi Pre-SET motif family protein 0.0065 0.0869 0.0996
Schistosoma mansoni voltage-gated potassium channel 0.0045 0.0459 0.0836
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0197 0.3548 0.6125
Toxoplasma gondii aldehyde dehydrogenase 0.006 0.0772 0.3185
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0157 0.2742 0.5829
Entamoeba histolytica hypothetical protein 0.0042 0.0407 0.0641
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.014 0.016
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0548 0.092
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0157 0.2742 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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