Detailed information for compound 584511

Basic information

Technical information
  • TDR Targets ID: 584511
  • Name: 10b-methyl-3-(3-methylbut-2-enyl)-1,2,4,4a,5, 6-hexahydrobenzo[f]isoquinolin-9-ol
  • MW: 285.424 | Formula: C19H27NO
  • H donors: 1 H acceptors: 1 LogP: 4.48 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(=CCN1CCC2(C(C1)CCc1c2cc(O)cc1)C)C
  • InChi: 1S/C19H27NO/c1-14(2)8-10-20-11-9-19(3)16(13-20)6-4-15-5-7-17(21)12-18(15)19/h5,7-8,12,16,21H,4,6,9-11,13H2,1-3H3
  • InChiKey: UBKGPRKTCCVVBP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 9-hydroxy-10-methyl-3-(3-methyl-2-butenyl)-1,2,3,4,4a,5,6,10b-octahydrobenzo(f)isoquinoline
  • 81124-85-8
  • Hmmboi
  • Benz(f)isoquinolin-9-ol, 1,2,3,4,4a,5,6,10b-octahydro-10b-methyl-3-(3-methyl-2-butenyl)-
  • NSC360528
  • NSC 360528

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.004 0.0568 0.0568
Schistosoma mansoni thyroid hormone receptor 0.017 0.4809 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0761 0.0761
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0026 0.0103 0.0213
Brugia malayi beta-lactamase 0.004 0.0568 0.0568
Loa Loa (eye worm) hypothetical protein 0.0051 0.0924 0.0924
Onchocerca volvulus 0.004 0.0568 0.0568
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0046 0.0743 0.8051
Toxoplasma gondii kringle domain-containing protein 0.0046 0.0743 0.0525
Echinococcus granulosus zinc finger protein 0.0027 0.0116 0.0272
Onchocerca volvulus 0.0328 1 1
Loa Loa (eye worm) TK/ROR protein kinase 0.0046 0.0743 0.0743
Schistosoma mansoni hypothetical protein 0.0046 0.0743 0.1545
Loa Loa (eye worm) raf kinase 0.0047 0.0777 0.0777
Loa Loa (eye worm) hypothetical protein 0.0045 0.0707 0.0707
Loa Loa (eye worm) hypothetical protein 0.0052 0.0956 0.0956
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0226 0.665 0.665
Loa Loa (eye worm) beta-lactamase 0.004 0.0568 0.0568
Loa Loa (eye worm) hypothetical protein 0.0053 0.0997 0.0997
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0073 0.1648 0.3872
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0761 0.1583
Brugia malayi cytoplasmic intermediate filament protein 0.0033 0.0326 0.0326
Mycobacterium leprae conserved hypothetical protein 0.004 0.0568 0.5
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0304 0.0633
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0042 0.0614 0.1443
Echinococcus granulosus lamin dm0 0.0062 0.1265 0.2973
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0568 0.1182
Schistosoma mansoni hypothetical protein 0.0024 0.003 0.0062
Schistosoma mansoni lamin 0.0062 0.1265 0.2632
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0146 0.405 0.9515
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.004 0.0568 0.0568
Echinococcus multilocularis lamin 0.0062 0.1265 0.2632
Echinococcus multilocularis musashi 0.0062 0.1265 0.2632
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0042 0.0614 0.1277
Brugia malayi Pre-SET motif family protein 0.0226 0.665 0.665
Leishmania major hypothetical protein, conserved 0.0046 0.0743 1
Onchocerca volvulus 0.004 0.0568 0.0568
Loa Loa (eye worm) hypothetical protein 0.004 0.0568 0.0568
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0761 0.0761
Brugia malayi PHD-finger family protein 0.0033 0.0319 0.0319
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0304 0.0633
Echinococcus multilocularis thyroid hormone receptor alpha 0.017 0.4809 1
Brugia malayi acetyltransferase, GNAT family protein 0.016 0.4492 0.4492
Brugia malayi Protein kinase domain containing protein 0.0046 0.0743 0.0743
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0568 0.1182
Mycobacterium ulcerans esterase/lipase LipP 0.004 0.0568 0.5
Loa Loa (eye worm) hypothetical protein 0.004 0.0568 0.0568
Schistosoma mansoni hypothetical protein 0.0146 0.405 0.8423
Schistosoma mansoni thyroid hormone receptor 0.017 0.4809 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0761 0.1789
Schistosoma mansoni lamin 0.0062 0.1265 0.2632
Brugia malayi intermediate filament protein 0.0062 0.1265 0.1265
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0052 0.0956 0.1987
Echinococcus granulosus intermediate filament protein 0.0062 0.1265 0.2973
Loa Loa (eye worm) acetyltransferase 0.016 0.4492 0.4492
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0026 0.0103 0.0213
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0049 0.0849 0.0395
Echinococcus multilocularis zinc finger protein 0.0027 0.0116 0.0241
Mycobacterium ulcerans hypothetical protein 0.004 0.0568 0.5
Loa Loa (eye worm) hypothetical protein 0.0062 0.1265 0.1265
Loa Loa (eye worm) hypothetical protein 0.0046 0.0743 0.0743
Toxoplasma gondii PAN domain-containing protein 0.0287 0.867 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0761 0.1583
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0073 0.1648 0.3428
Echinococcus granulosus histone acetyltransferase KAT2B 0.0049 0.0849 0.1995
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0761 0.1583
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0049 0.0849 0.0652
Onchocerca volvulus 0.0032 0.0304 0.0304
Onchocerca volvulus 0.004 0.0568 0.0568
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0049 0.0849 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0568 0.0568
Brugia malayi Pre-SET motif family protein 0.0032 0.0304 0.0304
Loa Loa (eye worm) hypothetical protein 0.0328 1 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0761 0.1583
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0049 0.0849 0.0652
Trichomonas vaginalis bromodomain-containing protein, putative 0.0049 0.0849 0.0395
Echinococcus multilocularis raf serine:threonine protein kinase 0.0047 0.0777 0.1616
Onchocerca volvulus 0.0062 0.1265 0.1265
Echinococcus granulosus tissue type plasminogen activator 0.0046 0.0743 0.1746
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.003 0.0218 0.0454
Loa Loa (eye worm) hypothetical protein 0.003 0.0218 0.0218
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.016 0.4492 0.9341
Loa Loa (eye worm) hypothetical protein 0.0029 0.0181 0.0181
Loa Loa (eye worm) intermediate filament protein 0.0062 0.1265 0.1265
Echinococcus granulosus histone lysine methyltransferase setb 0.0052 0.0956 0.2245
Trypanosoma brucei hypothetical protein, conserved 0.004 0.0568 0.5
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.004 0.0568 0.0568
Echinococcus multilocularis beta LACTamase domain containing family member 0.004 0.0568 0.1182
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0062 0.1265 0.1265
Mycobacterium ulcerans lipase LipD 0.004 0.0568 0.5
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0146 0.405 0.8423
Plasmodium vivax hypothetical protein, conserved 0.004 0.0568 0.4846
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0761 0.1583
Mycobacterium leprae Probable lipase LipE 0.004 0.0568 0.5
Entamoeba histolytica acetyltransferase, GNAT family 0.0042 0.0632 0.5
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0031 0.0265 0.0623
Loa Loa (eye worm) hypothetical protein 0.0082 0.1943 0.1943
Giardia lamblia Histone acetyltransferase GCN5 0.0042 0.0632 0.5
Loa Loa (eye worm) hypothetical protein 0.0061 0.1228 0.1228
Brugia malayi beta-lactamase family protein 0.004 0.0568 0.0568
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.016 0.4492 0.9341
Loa Loa (eye worm) hypothetical protein 0.004 0.0568 0.0568
Echinococcus multilocularis lamin dm0 0.0062 0.1265 0.2632
Trypanosoma cruzi hypothetical protein, conserved 0.0046 0.0743 1
Brugia malayi Kringle domain containing protein 0.0046 0.0743 0.0743
Echinococcus granulosus beta LACTamase domain containing family member 0.004 0.0568 0.1335
Schistosoma mansoni intermediate filament proteins 0.0062 0.1265 0.2632
Echinococcus granulosus lamin 0.0062 0.1265 0.2973
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0258 0.7718 1
Echinococcus granulosus cytoplasmic intermediate filament protein 0.003 0.0218 0.0513
Loa Loa (eye worm) PHD-finger family protein 0.0024 0.003 0.003
Brugia malayi Raf kinase 0.0047 0.0777 0.0777
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0761 0.1789
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0052 0.0956 0.1987
Loa Loa (eye worm) hypothetical protein 0.0029 0.0181 0.0181
Brugia malayi Bromodomain containing protein 0.0091 0.2233 0.2233
Mycobacterium ulcerans beta-lactamase 0.004 0.0568 0.5
Onchocerca volvulus 0.0257 0.7674 0.7674
Loa Loa (eye worm) bromodomain containing protein 0.0024 0.0043 0.0043
Echinococcus granulosus fetal alzheimer antigen falz 0.0026 0.0103 0.0241
Echinococcus granulosus raf serine:threonine protein kinase 0.0047 0.0777 0.1825
Echinococcus granulosus histone acetyltransferase KAT2B 0.0153 0.4256 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0052 0.0956 0.1987
Schistosoma mansoni bromodomain containing protein 0.0077 0.1785 0.3712
Loa Loa (eye worm) hypothetical protein 0.004 0.0568 0.0568
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0033 0.0326 0.0326
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0032 0.0304 0.0633
Brugia malayi Bromodomain containing protein 0.0048 0.0831 0.0831
Onchocerca volvulus 0.0046 0.0743 0.0743
Trichomonas vaginalis set domain proteins, putative 0.0257 0.7674 1
Toxoplasma gondii PAN domain-containing protein 0.0287 0.867 1
Schistosoma mansoni zinc finger protein 0.0027 0.0116 0.0241
Plasmodium falciparum cysteine repeat modular protein 1 0.0046 0.0743 1
Brugia malayi Intermediate filament tail domain containing protein 0.0062 0.1265 0.1265
Echinococcus multilocularis tissue type plasminogen activator 0.0046 0.0743 0.1545
Toxoplasma gondii ABC1 family protein 0.004 0.0568 0.0316
Onchocerca volvulus 0.0062 0.1265 0.1265
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.004 0.0568 0.5
Schistosoma mansoni serine/threonine protein kinase 0.0047 0.0777 0.1616
Brugia malayi beta-lactamase family protein 0.004 0.0568 0.0568

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.