Detailed information for compound 585897

Basic information

Technical information
  • TDR Targets ID: 585897
  • Name: 2-(1-adamantylamino)-1-(4-bromophenyl)ethanon e
  • MW: 348.277 | Formula: C18H22BrNO
  • H donors: 1 H acceptors: 1 LogP: 4.57 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1ccc(cc1)Br)CNC12CC3CC(C2)CC(C1)C3
  • InChi: 1S/C18H22BrNO/c19-16-3-1-15(2-4-16)17(21)11-20-18-8-12-5-13(9-18)7-14(6-12)10-18/h1-4,12-14,20H,5-11H2
  • InChiKey: LRELHWKXXPNAKX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-bromobenzoyl-methyladamantylamine
  • 84269-98-7
  • 1-(4-Bromophenyl)-2-(tricyclo(3.3.1.13,7)dec-1-ylamino)ethanone
  • 1-N-(4-Bromobenzoyl)methyladamantylamine
  • 1-N-(para-Bromobenzoyl)methyladamantylamine
  • BBMAA
  • Ethanone, 1-(4-bromophenyl)-2-(tricyclo(3.3.1.13,7)dec-1-ylamino)-
  • N-((4-Bromobenzoyl)methyl)-1-adamantylamine

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0208 0.0568
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0527 0.2494
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0527 0.0697
Trypanosoma brucei unspecified product 0.0014 0.0319 0.1372
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0208 0.0256
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0208 0.0286
Schistosoma mansoni nuclear hormone receptor 0.0005 0.0023 0.0031
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0527 0.2494
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0527 0.0448
Loa Loa (eye worm) hypothetical protein 0.001 0.0208 0.0256
Trypanosoma cruzi DNA/RNA non-specific endonuclease protein-like, putative 0.0061 0.1917 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.1444 0.1965
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0527 0.2494
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0208 0.0256
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0147 0.4812 1
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0007 0.0105 0.0252
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.03 1 1
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0208 0.0256
Onchocerca volvulus GPI ethanolamine phosphate transferase 2 homolog 0.0016 0.0396 0.0517
Onchocerca volvulus GPI ethanolamine phosphate transferase 1 homolog 0.0016 0.0396 0.0517
Trypanosoma brucei endonuclease G, putative 0.0061 0.1917 1
Schistosoma mansoni ectonucleotide pyrophosphatase/phosphodiesterase 0.0101 0.3285 0.4527
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0208 0.0568
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0208 0.0256
Loa Loa (eye worm) hypothetical protein 0.001 0.0208 0.0256
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0527 0.2494
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0101 0.3285 1
Brugia malayi nuclear receptor NHR-88 0.001 0.0208 0.0256
Onchocerca volvulus Bile acid receptor homolog 0.001 0.0208 0.0256
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0208 0.0256
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0208 0.0286
Leishmania major DNA/RNA non-specific endonuclease-like protein 0.0061 0.1917 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0208 0.0256
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.1444 0.199
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0208 0.0568
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0319 0.1372
Loa Loa (eye worm) hypothetical protein 0.0016 0.0396 0.0517
Loa Loa (eye worm) type I phosphodiesterase/nucleotide pyrophosphatase 0.0016 0.0396 0.0517
Onchocerca volvulus 0.0101 0.3285 0.451
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0208 0.0286
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.03 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0319 0.1372
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0005 0.0023 0.0031
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.1444 0.4358
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0101 0.3285 1
Echinococcus granulosus Endonuclease G 0.0061 0.1917 0.5805
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0161 0.0192
Onchocerca volvulus Protein ultraspiracle homolog 0.001 0.0208 0.0256
Brugia malayi CXXC zinc finger family protein 0.0029 0.0854 0.1149
Echinococcus multilocularis ectonucleotide 0.0085 0.2746 0.8347
Trypanosoma brucei unspecified product 0.002 0.0527 0.2494
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0527 0.2494
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0208 0.0568
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0527 0.0697
Echinococcus multilocularis transferase 0.0016 0.0396 0.1146
Onchocerca volvulus GPI ethanolamine phosphate transferase 3 homolog 0.0016 0.0396 0.0517
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0208 0.0256
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0208 0.0256
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0208 0.0256
Echinococcus multilocularis gpi ethanolamine phosphate transferase 3 0.0016 0.0396 0.1146
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0007 0.0105 0.0252
Onchocerca volvulus 0.0029 0.0854 0.1149
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.1444 0.4358
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0007 0.0105 0.0252
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0208 0.0286
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0208 0.0256
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0101 0.3285 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0527 0.0697
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0527 0.2494
Schistosoma mansoni endonuclease related 0.0061 0.1917 0.2641
Echinococcus multilocularis cpg binding protein 0.0031 0.0911 0.2722
Brugia malayi hypothetical protein 0.0005 0.0042 0.0027
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0208 0.0256
Trypanosoma cruzi DNA/RNA non-specific endonuclease protein-like, putative 0.0061 0.1917 1
Echinococcus multilocularis dna polymerase kappa 0.002 0.0527 0.1546
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0005 0.0042 0.0027
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0854 0.1149
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0208 0.0568
Onchocerca volvulus Ectonucleotide pyrophosphatase\/phosphodiesterase family member 7 homolog 0.0016 0.0396 0.0517
Loa Loa (eye worm) hypothetical protein 0.001 0.0208 0.0256
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0208 0.0256
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0208 0.0256
Brugia malayi AEL166Cp 0.0016 0.0396 0.0517
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0208 0.0568
Schistosoma mansoni cpg binding protein 0.0031 0.0911 0.1255
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0208 0.0256
Loa Loa (eye worm) hypothetical protein 0.001 0.0208 0.0256
Toxoplasma gondii DNA/RNA non-specific endonuclease 0.0061 0.1917 1
Leishmania major DNA polymerase kappa, putative 0.002 0.0527 0.2494
Schistosoma mansoni coup transcription factor 0.001 0.0208 0.0286
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0208 0.0286
Leishmania major ethanolamine phosphotransferase, putative 0.0016 0.0396 0.1789
Brugia malayi hypothetical protein 0.0016 0.0396 0.0517
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0527 0.2494
Echinococcus granulosus dna polymerase kappa 0.002 0.0527 0.1546
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0165 0.0198
Echinococcus granulosus ectonucleotide 0.0085 0.2746 0.8347
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0208 0.0256
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0208 0.0568
Echinococcus multilocularis Alkaline phosphatase, core domain 0.0016 0.0396 0.1146
Loa Loa (eye worm) thrombospondin type 1 domain-containing protein 0.0219 0.7258 1
Onchocerca volvulus 0.001 0.0208 0.0256
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0527 0.0973
Brugia malayi steroid hormone receptor 0.001 0.0208 0.0256
Plasmodium falciparum GPI ethanolamine phosphate transferase 3, putative 0.0016 0.0396 1
Echinococcus multilocularis dna polymerase eta 0.002 0.0527 0.1546
Onchocerca volvulus 0.0101 0.3285 0.451
Echinococcus multilocularis gpi ethanolamine phosphate transferase 1 0.0016 0.0396 0.1146
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0319 0.1372
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0005 0.0042 0.0058
Schistosoma mansoni nuclear receptor 0.0005 0.0023 0.0031
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.03 1 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0396 0.0517
Brugia malayi ecdysteroid receptor 0.001 0.0208 0.0256
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0527 0.2494
Trypanosoma cruzi endonuclease G, putative 0.0061 0.1917 1
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0208 0.0286
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0208 0.0568
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0208 0.0568
Loa Loa (eye worm) hypothetical protein 0.0005 0.0042 0.0027
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0208 0.0256
Schistosoma mansoni DNA polymerase eta 0.002 0.0527 0.0726
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0005 0.0042 0.0061
Toxoplasma gondii histone lysine methyltransferase SET1 0.0056 0.1745 0.9075
Brugia malayi Thrombospondin type 1 domain containing protein 0.0219 0.7258 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0208 0.0256
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0208 0.0568
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0527 0.2494
Brugia malayi Type I phosphodiesterase / nucleotide pyrophosphatase family protein 0.0101 0.3285 0.451
Onchocerca volvulus 0.0219 0.7258 1
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0527 0.2494
Loa Loa (eye worm) hypothetical protein 0.0101 0.3285 0.451
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0527 0.0697
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0208 0.0568
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0147 0.4812 1
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0527 0.0726
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.03 1 1
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0005 0.0042 0.0061
Schistosoma mansoni nuclear hormone receptor 0.0005 0.0023 0.0031
Giardia lamblia Phosphatidylinositol-glycan biosynthesis, class O protein 0.0016 0.0396 0.0334
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0208 0.0286
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.1444 0.1965
Giardia lamblia Fructose-bisphosphate aldolase 0.03 1 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.03 1 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.03 1 1
Schistosoma mansoni nuclear receptor 0.0005 0.0023 0.0031
Loa Loa (eye worm) hypothetical protein 0.0085 0.2746 0.3764
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0101 0.3285 1
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0101 0.3285 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.03 1 1
Loa Loa (eye worm) hypothetical protein 0.0101 0.3285 0.451
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0208 0.0256
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0165 0.0438
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.0527 0.2494
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0101 0.3285 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0063 0.1971 0.2716
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.03 1 1
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0208 0.0256
Loa Loa (eye worm) hypothetical protein 0.0006 0.0065 0.0059
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0101 0.3285 1
Schistosoma mansoni zinc finger protein 0.0005 0.0023 0.0031
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0527 0.0448
Brugia malayi Nuclear hormone receptor-like 1 0.0005 0.0042 0.0027
Trypanosoma brucei unspecified product 0.0014 0.0319 0.1372
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0527 0.2494
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0208 0.0256
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0016 0.0396 0.1146
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0527 0.2494
Loa Loa (eye worm) hypothetical protein 0.001 0.0208 0.0256
Echinococcus granulosus mixed lineage leukemia protein mll 0.0007 0.0105 0.0252
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0208 0.0256
Schistosoma mansoni thyroid hormone receptor 0.001 0.0208 0.0286
Brugia malayi nuclear receptor RXR 0.0005 0.0042 0.0027
Loa Loa (eye worm) hypothetical protein 0.0005 0.0042 0.0027
Leishmania major endonuclease G, putative 0.0061 0.1917 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.1444 0.199
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.1444 0.199
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0016 0.0396 0.1146
Echinococcus granulosus gpi ethanolamine phosphate transferase 3 0.0016 0.0396 0.1146
Schistosoma mansoni nuclear receptor nhr-48 0.0005 0.0023 0.0031
Treponema pallidum fructose-bisphosphate aldolase 0.03 1 0.5
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0007 0.0105 0.0144
Schistosoma mansoni hypothetical protein 0.0016 0.0396 0.0546
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0085 0.2746 0.8347
Schistosoma mansoni ectonucleotide pyrophosphatase/phosphodiesterase 0.0101 0.3285 0.4527
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0208 0.0256
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.1444 0.4358
Schistosoma mansoni ectonucleotide pyrophosphatase/phosphodiesterase 0.0101 0.3285 0.4527
Trypanosoma brucei endonuclease G, putative 0.0061 0.1917 1
Brugia malayi hypothetical protein 0.0016 0.0396 0.0517
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0101 0.3285 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0208 0.0568
Brugia malayi endonuclease G, mitochondrial precursor 0.0061 0.1917 0.2618
Brugia malayi nuclear hormone receptor 0.001 0.0208 0.0256
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.1444 0.4358
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0208 0.0256
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0527 0.2494
Schistosoma mansoni nuclear hormone receptor 0.001 0.0208 0.0286
Loa Loa (eye worm) hypothetical protein 0.0101 0.3285 0.451
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0208 0.0568
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0005 0.0023 0.0031
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0101 0.3285 1
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0527 0.2494
Loa Loa (eye worm) hypothetical protein 0.0005 0.0042 0.0027
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0208 0.0568
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.001 0.0208 0.0256
Loa Loa (eye worm) hypothetical protein 0.0016 0.0396 0.0517
Schistosoma mansoni hypothetical protein 0.0219 0.7258 1
Schistosoma mansoni ectonucleotide pyrophosphatase/phosphodiesterase 0.0016 0.0396 0.0546
Schistosoma mansoni hypothetical protein 0.0016 0.0396 0.0546
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0208 0.0256
Brugia malayi hypothetical protein 0.0005 0.0042 0.0027
Loa Loa (eye worm) hypothetical protein 0.0016 0.0396 0.0517
Echinococcus granulosus cpg binding protein 0.0031 0.0911 0.2722
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0101 0.3285 1
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0527 0.2494
Trypanosoma brucei GPI ethanolamine phosphate transferase 3, putative 0.0016 0.0396 0.1789
Giardia lamblia DINP protein human, muc B family 0.002 0.0527 0.0465
Leishmania major DNA polymerase eta, putative 0.002 0.0527 0.2494
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0527 0.0973
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0085 0.2746 0.8347
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0005 0.0042 0.0058
Schistosoma mansoni DNA polymerase IV / kappa 0.0006 0.0065 0.0089
Trypanosoma brucei endonuclease G, putative 0.0061 0.1917 1
Schistosoma mansoni cpg binding protein 0.0031 0.0911 0.1255
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0527 0.0726
Brugia malayi Nuclear hormone receptor-like 1 0.0005 0.0042 0.0027
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0016 0.0396 0.1146
Brugia malayi polk-prov protein 0.0006 0.0065 0.0059
Schistosoma mansoni ectonucleotide pyrophosphatase/phosphodiesterase 0.0101 0.3285 0.4527
Echinococcus granulosus FTZ F1 alpha 0.001 0.0208 0.0568
Echinococcus multilocularis Endonuclease G 0.0061 0.1917 0.5805
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0208 0.0568
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0208 0.0568
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.03 1 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0208 0.0256
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0208 0.0256
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0147 0.4812 1
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0527 0.2494
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0165 0.0438
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0527 0.1546
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0101 0.3285 1
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.0527 0.2494
Schistosoma mansoni thyroid hormone receptor 0.001 0.0208 0.0286
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0527 0.2494
Trypanosoma cruzi endonuclease G, putative 0.0061 0.1917 1
Schistosoma mansoni hypothetical protein 0.0016 0.0396 0.0546
Brugia malayi Type I phosphodiesterase / nucleotide pyrophosphatase family protein 0.0016 0.0396 0.0517
Echinococcus granulosus transferase 0.0016 0.0396 0.1146
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0527 0.1546
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0208 0.0286
Onchocerca volvulus Ectonucleotide pyrophosphatase\/phosphodiesterase family member 6 homolog 0.0016 0.0396 0.0517
Schistosoma mansoni cpg binding protein 0.0029 0.0854 0.1176
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0208 0.0568
Plasmodium vivax DNA repair protein REV1, putative 0.0006 0.0065 0.5
Loa Loa (eye worm) hypothetical protein 0.0005 0.0042 0.0027
Loa Loa (eye worm) hypothetical protein 0.001 0.0208 0.0256
Schistosoma mansoni hypothetical protein 0.0016 0.0396 0.0546
Entamoeba histolytica deoxycytidyl transferase, putative 0.002 0.0527 0.0136
Echinococcus granulosus dna polymerase eta 0.002 0.0527 0.1546
Loa Loa (eye worm) hypothetical protein 0.0005 0.0042 0.0027
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0527 0.2494
Mycobacterium ulcerans hypothetical protein 0.0016 0.0396 0.0698
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0208 0.0286

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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