Detailed information for compound 594963

Basic information

Technical information
  • TDR Targets ID: 594963
  • Name: N-[4-(4-methyl-1,3-thiazol-2-yl)-1,2,5-oxadia zol-3-yl]-2-(2-propan-2-ylphenoxy)acetamide
  • MW: 358.415 | Formula: C17H18N4O3S
  • H donors: 1 H acceptors: 4 LogP: 3.21 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1nonc1c1scc(n1)C)COc1ccccc1C(C)C
  • InChi: 1S/C17H18N4O3S/c1-10(2)12-6-4-5-7-13(12)23-8-14(22)19-16-15(20-24-21-16)17-18-11(3)9-25-17/h4-7,9-10H,8H2,1-3H3,(H,19,21,22)
  • InChiKey: NSGAHJKQJUWCFV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-(2-isopropylphenoxy)-N-[4-(4-methylthiazol-2-yl)-1,2,5-oxadiazol-3-yl]acetamide
  • 2-(2-isopropylphenoxy)-N-[4-(4-methyl-2-thiazolyl)-1,2,5-oxadiazol-3-yl]acetamide
  • 2-(2-isopropylphenoxy)-N-[4-(4-methylthiazol-2-yl)furazan-3-yl]acetamide
  • N-[4-(4-methyl-1,3-thiazol-2-yl)-1,2,5-oxadiazol-3-yl]-2-(2-propan-2-ylphenoxy)ethanamide
  • ZINC08075438
  • T5540685

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0038 0.0267 0.0267
Schistosoma mansoni tar DNA-binding protein 0.0137 0.1705 0.3736
Mycobacterium ulcerans hypothetical protein 0.0111 0.133 0.4595
Mycobacterium tuberculosis Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH) 0.0076 0.0817 0.0817
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0097 0.1124 0.2463
Loa Loa (eye worm) mbt repeat family protein 0.0054 0.0509 0.1401
Loa Loa (eye worm) TAR-binding protein 0.0137 0.1705 0.4697
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0219 0.2895 1
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0104 0.1227 0.3379
Echinococcus multilocularis inositol monophosphatase 1 0.0042 0.0331 0.1144
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0041 0.0322 0.1111
Brugia malayi TAR-binding protein 0.0137 0.1705 0.4697
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0219 0.2895 1
Toxoplasma gondii glyceraldehyde-3-phosphate dehydrogenase GAPDH1 0.0219 0.2895 1
Brugia malayi RNA binding protein 0.0137 0.1705 0.4697
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0097 0.1124 0.3885
Toxoplasma gondii glyceraldehyde-3-phosphate dehydrogenase GAPDH2 0.0219 0.2895 1
Brugia malayi RNA recognition motif domain containing protein 0.0137 0.1705 0.4697
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0111 0.133 0.2914
Entamoeba histolytica hypothetical protein 0.0041 0.0322 0.1111
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0054 0.0509 0.3305
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.0219 0.2895 1
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0068 0.0704 0.2433
Schistosoma mansoni myelin transcription factor 1 myt1 0.0062 0.0618 0.1353
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0111 0.133 0.4595
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0054 0.0509 0.1115
Mycobacterium tuberculosis Probable esterase LipL 0.0111 0.133 0.133
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0097 0.1124 0.3097
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.0219 0.2895 1
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, cytosolic 0.0219 0.2895 1
Entamoeba histolytica serine/threonine protein kinase, putative 0.0104 0.1227 0.4238
Mycobacterium ulcerans esterase/lipase LipP 0.0111 0.133 0.4595
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0041 0.0322 0.1111
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0068 0.0704 0.2433
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0103 0.0285
Trichomonas vaginalis inositol monophosphatase, putative 0.0042 0.0331 0.1144
Brugia malayi mbt repeat family protein 0.0054 0.0509 0.1401
Schistosoma mansoni tar DNA-binding protein 0.0137 0.1705 0.3736
Plasmodium vivax hypothetical protein, conserved 0.0111 0.133 0.4595
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0042 0.0331 0.1144
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0097 0.1124 0.3885
Echinococcus multilocularis musashi 0.0026 0.0103 0.0357
Loa Loa (eye worm) hypothetical protein 0.0026 0.0096 0.0265
Chlamydia trachomatis glyceraldehyde-3-phosphate dehydrogenase 0.0219 0.2895 0.5
Trichomonas vaginalis CAMK family protein kinase 0.0051 0.0467 0.1612
Loa Loa (eye worm) hypothetical protein 0.0111 0.133 0.3664
Echinococcus multilocularis polycomb protein SCMH1 0.0054 0.0509 0.1758
Schistosoma mansoni inositol monophosphatase 0.0042 0.0331 0.0725
Echinococcus granulosus geminin 0.0193 0.2517 0.8695
Onchocerca volvulus 0.0111 0.133 1
Loa Loa (eye worm) hypothetical protein 0.0054 0.0509 0.1401
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0097 0.1124 0.2463
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0219 0.2895 1
Mycobacterium ulcerans beta-lactamase 0.0111 0.133 0.4595
Mycobacterium leprae Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH) 0.0076 0.0817 0.5176
Trypanosoma brucei glyceraldehyde-3-phosphate dehydrogenase, putative 0.0143 0.1799 0.6214
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0219 0.2895 1
Treponema pallidum glyceraldehyde 3-phosphate dehydrogenase (gap) 0.0219 0.2895 1
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0143 0.18 0.622
Echinococcus granulosus beta LACTamase domain containing family member 0.0111 0.133 0.4595
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0097 0.1124 0.3885
Giardia lamblia Glyceraldehyde 3-phosphate dehydrogenase 0.0143 0.1799 0.6214
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0104 0.1227 0.4238
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0111 0.133 0.133
Brugia malayi Glyceraldehyde 3-phosphate dehydrogenase 0.0075 0.0816 0.2247
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0042 0.0331 0.1144
Leishmania major glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0219 0.2895 1
Mycobacterium tuberculosis Conserved protein 0.0111 0.133 0.133
Brugia malayi beta-lactamase family protein 0.0111 0.133 0.3664
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0219 0.2895 0.6341
Trichomonas vaginalis CAMK family protein kinase 0.0104 0.1227 0.4238
Schistosoma mansoni hypothetical protein 0.0193 0.2517 0.5514
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.0219 0.2895 1
Echinococcus multilocularis lamin 0.0026 0.0103 0.0357
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0103 0.0285
Brugia malayi Glyceraldehyde 3-phosphate dehydrogenase 0.0219 0.2895 0.7974
Brugia malayi intermediate filament protein 0.0026 0.0103 0.0285
Loa Loa (eye worm) glyceraldehyde-3-phosphate dehydrogenase 0.0151 0.1912 0.5266
Loa Loa (eye worm) hypothetical protein 0.0026 0.0103 0.0285
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain, putative 0.0068 0.0704 0.2433
Schistosoma mansoni hypothetical protein 0.0334 0.4565 1
Loa Loa (eye worm) hypothetical protein 0.0111 0.133 0.3664
Trypanosoma brucei polo-like protein kinase 0.0104 0.1227 0.4238
Plasmodium vivax glyceraldehyde-3-phosphate dehydrogenase, putative 0.0219 0.2895 1
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0042 0.0331 0.1144
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0042 0.0331 0.1144
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0104 0.1227 0.4238
Trichomonas vaginalis CAMK family protein kinase 0.0104 0.1227 0.4238
Trichomonas vaginalis CAMK family protein kinase 0.0104 0.1227 0.4238
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.0219 0.2895 1
Plasmodium falciparum glyceraldehyde-3-phosphate dehydrogenase 0.0219 0.2895 1
Brugia malayi serine/threonine-protein kinase plk-2 0.0104 0.1227 0.3379
Brugia malayi glyceraldehyde 3-phosphate dehydrogenase 0.0068 0.0704 0.194
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0219 0.2895 1
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0218 0.2881 0.9952
Onchocerca volvulus 0.0054 0.0509 0.3305
Echinococcus multilocularis lamin dm0 0.0026 0.0103 0.0357
Loa Loa (eye worm) hypothetical protein 0.0111 0.133 0.3664
Schistosoma mansoni tar DNA-binding protein 0.0137 0.1705 0.3736
Onchocerca volvulus 0.0111 0.133 1
Mycobacterium leprae conserved hypothetical protein 0.0111 0.133 1
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0042 0.0331 0.1144
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0219 0.2895 0.6341
Brugia malayi hypothetical protein 0.0041 0.0322 0.0886
Schistosoma mansoni transcription factor LCR-F1 0.0041 0.0322 0.0705
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0042 0.0331 0.1144
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0104 0.1227 0.4238
Schistosoma mansoni sex comb on midleg homolog 0.0054 0.0509 0.1115
Mycobacterium tuberculosis Conserved protein 0.0111 0.133 0.133
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.0219 0.2895 1
Leishmania major glyceraldehyde-3-phosphate dehydrogenase-like protein 0.0143 0.1799 0.6214
Trichomonas vaginalis CAMK family protein kinase 0.0104 0.1227 0.4238
Leishmania major hypothetical protein, conserved 0.0111 0.133 0.4595
Schistosoma mansoni lamin 0.0026 0.0103 0.0226
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.0219 0.2895 1
Schistosoma mansoni serine/threonine protein kinase 0.0104 0.1227 0.2688
Loa Loa (eye worm) glyceraldehyde 3-phosphate dehydrogenase 0.0143 0.18 0.4959
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0219 0.2895 1
Leishmania major glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0219 0.2895 1
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0269 0.363 1
Entamoeba histolytica hypothetical protein 0.0041 0.0322 0.1111
Echinococcus granulosus lamin dm0 0.0026 0.0103 0.0357
Schistosoma mansoni hypothetical protein 0.0041 0.0322 0.0705
Loa Loa (eye worm) glyceraldehyde-3-phosphate dehydrogenase 0.0151 0.1912 0.5266
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0219 0.2895 1
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0042 0.0331 0.1144
Echinococcus granulosus lamin 0.0026 0.0103 0.0357
Mycobacterium ulcerans lipase LipD 0.0111 0.133 0.4595
Trichomonas vaginalis penicillin-binding protein, putative 0.0111 0.133 0.4595
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0103 0.0285
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.0219 0.2895 1
Entamoeba histolytica hypothetical protein 0.0041 0.0322 0.1111
Trichomonas vaginalis D-aminoacylase, putative 0.0111 0.133 0.4595
Brugia malayi mbt repeat family protein 0.0054 0.0509 0.1401
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0219 0.2895 1
Brugia malayi beta-lactamase family protein 0.0111 0.133 0.3664
Loa Loa (eye worm) hypothetical protein 0.0062 0.0618 0.1702
Loa Loa (eye worm) MBCTL1 0.0062 0.0618 0.1702
Echinococcus granulosus tar DNA binding protein 0.0137 0.1705 0.5891
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0075 0.0816 0.2817
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0062 0.0618 0.2134
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0062 0.0618 0.2134
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0219 0.2895 1
Entamoeba histolytica hypothetical protein 0.0041 0.0322 0.1111
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0042 0.0331 0.1144
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0111 0.133 0.3664
Trypanosoma brucei hypothetical protein, conserved 0.0111 0.133 0.4595
Trichomonas vaginalis CAMK family protein kinase 0.0104 0.1227 0.4238
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain, putative 0.0068 0.0704 0.2433
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0219 0.2895 1
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0219 0.2895 1
Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase, putative 0.0143 0.1799 0.6214
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0097 0.1124 0.2463
Echinococcus multilocularis geminin 0.0193 0.2517 0.8695
Schistosoma mansoni lamin 0.0026 0.0103 0.0226
Schistosoma mansoni tar DNA-binding protein 0.0137 0.1705 0.3736
Schistosoma mansoni tar DNA-binding protein 0.0137 0.1705 0.3736
Echinococcus multilocularis beta LACTamase domain containing family member 0.0111 0.133 0.4595
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0062 0.0618 0.1702
Onchocerca volvulus Serine\/threonine kinase homolog 0.0104 0.1227 0.9158
Trichomonas vaginalis D-aminoacylase, putative 0.0111 0.133 0.4595
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0097 0.1124 0.3097
Loa Loa (eye worm) hypothetical protein 0.0111 0.133 0.3664
Mycobacterium leprae Probable lipase LipE 0.0111 0.133 1
Echinococcus multilocularis SAM and MBT domain containing protein 0.0054 0.0509 0.1758
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0097 0.1124 0.3885
Schistosoma mansoni sex comb on midleg homolog 0.0054 0.0509 0.1115
Loa Loa (eye worm) beta-lactamase 0.0111 0.133 0.3664
Schistosoma mansoni intermediate filament proteins 0.0026 0.0103 0.0226
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0219 0.2895 1
Echinococcus granulosus polycomb protein SCMH1 0.0054 0.0509 0.1758
Mycobacterium tuberculosis Probable lipase LipE 0.0111 0.133 0.133
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.0143 0.18 0.622
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0111 0.133 0.2914
Loa Loa (eye worm) hypothetical protein 0.0111 0.133 0.3664
Echinococcus granulosus inositol monophosphatase 1 0.0042 0.0331 0.1144
Giardia lamblia Glyceraldehyde 3-phosphate dehydrogenase 0.0219 0.2895 1
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0111 0.133 0.3664
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0218 0.2881 0.9952
Trichomonas vaginalis esterase, putative 0.0111 0.133 0.4595
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.0143 0.18 0.622
Brugia malayi follicle stimulating hormone receptor 0.0269 0.363 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0111 0.133 0.4595
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0219 0.2895 0.6341
Trichomonas vaginalis CAMK family protein kinase 0.0104 0.1227 0.4238
Loa Loa (eye worm) RNA binding protein 0.0137 0.1705 0.4697
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0219 0.2895 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0137 0.1705 0.4697
Trypanosoma cruzi hypothetical protein, conserved 0.0111 0.133 0.4595
Schistosoma mansoni inositol monophosphatase 0.0042 0.0331 0.0725
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0111 0.133 0.133
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0042 0.0331 0.1144
Echinococcus granulosus intermediate filament protein 0.0026 0.0103 0.0357
Echinococcus multilocularis tar DNA binding protein 0.0137 0.1705 0.5891
Loa Loa (eye worm) hypothetical protein 0.0111 0.133 0.3664
Trichomonas vaginalis D-aminoacylase, putative 0.0111 0.133 0.4595
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0143 0.18 0.622
Wolbachia endosymbiont of Brugia malayi glyceraldehyde-3-phosphate dehydrogenase, GapA 0.0219 0.2895 1
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0219 0.2895 1
Trypanosoma cruzi polo-like protein kinase, putative 0.0104 0.1227 0.4238
Brugia malayi beta-lactamase 0.0111 0.133 0.3664
Echinococcus multilocularis histone acetyltransferase MYST2 0.0062 0.0618 0.2134
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0042 0.0331 0.1144
Loa Loa (eye worm) inositol-1 0.0042 0.0331 0.0912
Echinococcus granulosus histone acetyltransferase MYST2 0.0062 0.0618 0.2134
Onchocerca volvulus 0.0111 0.133 1
Echinococcus granulosus SAM and MBT domain containing protein 0.0054 0.0509 0.1758
Loa Loa (eye worm) hypothetical protein 0.0143 0.18 0.4959
Toxoplasma gondii ABC1 family protein 0.0111 0.133 0.4595
Trichomonas vaginalis CAMK family protein kinase 0.0104 0.1227 0.4238
Mycobacterium tuberculosis Probable hydrolase 0.0111 0.133 0.133
Trypanosoma cruzi polo-like protein kinase, putative 0.0104 0.1227 0.4238
Mycobacterium tuberculosis Conserved protein 0.0111 0.133 0.133
Mycobacterium tuberculosis Probable lipase LipD 0.0111 0.133 0.133
Schistosoma mansoni hypothetical protein 0.0193 0.2517 0.5514
Mycobacterium ulcerans glyceraldehyde 3-phosphate dehydrogenase Gap 0.0219 0.2895 1
Giardia lamblia Kinase, PLK 0.0104 0.1227 0.4238
Brugia malayi Inositol-1 0.0042 0.0331 0.0912
Loa Loa (eye worm) glyceraldehyde 3-phosphate dehydrogenase 0.0143 0.18 0.4959
Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase, putative 0.0143 0.1799 0.6214
Trichomonas vaginalis CAMK family protein kinase 0.0051 0.0467 0.1612
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0068 0.0704 0.2433
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0111 0.133 0.133
Trypanosoma cruzi hypothetical protein, conserved 0.0111 0.133 0.4595
Schistosoma mansoni kinase 0.0053 0.0486 0.1066
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0219 0.2895 0.6341

Activities

Activity type Activity value Assay description Source Reference
Inhibition (functional) = -1.84 % ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmPfHT that are glucose transport deficient and complemented with the Plasmodium falciparum hexose transporter. Activity is measured by by DNA content using SYBR green in vitro ChEMBL. No reference
Inhibition (functional) = 0 % GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 LDH activity, using an LDH reporter assay. Test compounds present at 2uM ChEMBL. 20485427
Inhibition (functional) = 2.07 % ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGLUT1 that are glucose transport deficient and complemented with the human glucose transporter GLUT1. Activity is measured by DNA content using SYBR green in vitro ChEMBL. No reference
Inhibition (functional) = 2.3 % ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGT2 that are glucose transport deficient and complemented with the L. Mexicana glucose transporter 2. Activity is measured by by DNA content using SYBR green in vitro ChEMBL. No reference
Inhibition (functional) = 14 % GSK_TCMDC: Percent inhibition of human HepG2 cell line. Test compounds present at 10uM. ChEMBL. 20485427
Inhibition (functional) = 85 % GSK_TCMDC: Inhibition of Plasmodium falciparum Dd2 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM ChEMBL. 20485427
Inhibition (functional) = 90 % GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM ChEMBL. 20485427
Inhibition frequency index (IFI) (functional) = 0 Inhibition Frequency Index (IFI) GSK. 20485427
Percent growth inhibition (functional) = -1 % Percent inhibition of P. falciparum lactate dehydrogenase activity (at 2 uM) GSK. 20485427
Percent growth inhibition (functional) = 14 % Percent inhibition of HepG2 growth (at 10 uM) GSK. 20485427
Percent growth inhibition (functional) = 85 % Percent inhibition of P. falciparum Dd2 growth (at 2 uM) GSK. 20485427
Percent growth inhibition (functional) = 90 % Percent inhibition of P. falciparum 3D7 growth (at 2 uM) GSK. 20485427
XC50 (functional) = 6.26 XC50 determination of P. falciparum 3D7 growth GSK. 20485427
XC50 (functional) = 0.55075 uM GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole erythrocytes, using parasite LDH activity as an index of growth. ChEMBL. 20485427

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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