Detailed information for compound 595553

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 465.975 | Formula: C25H28ClN5O2
  • H donors: 3 H acceptors: 3 LogP: 3.79 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1cc(C)nc2c1cccc2)NCCN1CCC(CC1)NC(=O)c1ccc(cc1)Cl
  • InChi: 1S/C25H28ClN5O2/c1-17-16-23(21-4-2-3-5-22(21)28-17)30-25(33)27-12-15-31-13-10-20(11-14-31)29-24(32)18-6-8-19(26)9-7-18/h2-9,16,20H,10-15H2,1H3,(H,29,32)(H2,27,28,30,33)
  • InChiKey: BZHBCKIMZUCEJE-UHFFFAOYSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium leprae Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase) (ThrRS) (Threonine-tRNA ligase) 0.0012 0.0011 0.0218
Schistosoma mansoni glucose transport protein 0.0207 0.1562 0.1561
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.02 0.1165
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0149 0.0723
Brugia malayi latrophilin 2 splice variant baaae 0.007 0.0475 0.257
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0083 0.1079
Loa Loa (eye worm) hypothetical protein 0.0035 0.02 0.1049
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0072 0.0493 0.6403
Chlamydia trachomatis pyruvate kinase 0.0072 0.0494 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0099 0.0703 0.0693
Loa Loa (eye worm) hypothetical protein 0.0035 0.02 0.1049
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0039 0.023 0.465
Echinococcus multilocularis General substrate transporter 0.0178 0.1331 0.1322
Trypanosoma brucei glucose transporter, putative 0.0064 0.0428 0.5558
Toxoplasma gondii lysine-tRNA ligase 0.0046 0.0285 0.0625
Leishmania major hypothetical protein, conserved 0.0029 0.0149 0.194
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0207 0.1562 0.1553
Trichomonas vaginalis CAMK family protein kinase 0.0107 0.077 0.3725
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0149 0.0723
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.02 0.0199
Plasmodium falciparum calcium-dependent protein kinase 2 0.0064 0.0425 0.0613
Trypanosoma brucei THT1 - hexose transporter, putative 0.0064 0.0428 0.5558
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.021 0.1018
Schistosoma mansoni cpg binding protein 0.0094 0.0667 0.0665
Loa Loa (eye worm) hypothetical protein 0.0046 0.0285 0.1518
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0067 0.0846
Trypanosoma brucei unspecified product 0.0021 0.0083 0.1079
Brugia malayi major facilitator superfamily protein 0.0029 0.0149 0.0767
Echinococcus multilocularis pyruvate kinase 0.0037 0.0214 0.0203
Trichomonas vaginalis conserved hypothetical protein 0.0064 0.0428 0.2071
Echinococcus granulosus pyruvate kinase 0.0037 0.0214 0.0203
Trichomonas vaginalis CAMK family protein kinase 0.0107 0.077 0.3725
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0107 0.077 1
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0149 0.0723
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0046 0.0285 0.1379
Leishmania major glucose transporter, lmgt2 0.0064 0.0428 0.5558
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.021 0.2732
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0021 0.0083 0.0072
Onchocerca volvulus 0.0035 0.02 0.0266
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0149 0.0723
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.02 0.0969
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0039 0.023 0.1336
Entamoeba histolytica hypothetical protein 0.0046 0.0285 0.3688
Leishmania major threonyl-tRNA synthetase, putative 0.0012 0.0011 0.014
Loa Loa (eye worm) hypothetical protein 0.0029 0.0149 0.0767
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0079 0.038
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0064 0.0424 0.0414
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0083 0.1079
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0203 0.0201
Onchocerca volvulus Pyruvate kinase homolog 0.0072 0.0494 0.1798
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0149 0.0723
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0029 0.0149 0.3023
Echinococcus multilocularis dna polymerase kappa 0.0021 0.0083 0.0072
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0032 0.0415
Trichomonas vaginalis CAMK family protein kinase 0.0064 0.0424 0.2052
Brugia malayi follicle stimulating hormone receptor 0.0239 0.1819 1
Brugia malayi major facilitator superfamily protein 0.0029 0.0149 0.0767
Schistosoma mansoni cpg binding protein 0.0094 0.0667 0.0665
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.02 0.1165
Schistosoma mansoni sugar transporter 0.0029 0.0149 0.0148
Echinococcus granulosus dna polymerase kappa 0.0021 0.0083 0.0072
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0023 0.0104 0.0102
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0062 0.0411 0.5332
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0083 0.1079
Mycobacterium ulcerans glycyl-tRNA synthetase 0.0012 0.0011 0.0218
Trichomonas vaginalis CAMK family protein kinase 0.0055 0.0356 0.1721
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0083 0.1079
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0062 0.0411 0.199
Brugia malayi Pyruvate kinase, muscle isozyme 0.0072 0.0494 0.2675
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0037 0.021 0.2715
Echinococcus granulosus inositol monophosphatase 1 0.0037 0.021 0.02
Trypanosoma brucei polo-like protein kinase 0.0107 0.077 1
Mycobacterium ulcerans beta-lactamase 0.0035 0.02 0.4053
Trypanosoma brucei glucose transporter 1E 0.0064 0.0428 0.5558
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0039 0.0226 0.0215
Trichomonas vaginalis sugar transporter, putative 0.0064 0.0428 0.2071
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.0385 0.0375
Mycobacterium ulcerans hypothetical protein 0.0035 0.02 0.4053
Echinococcus multilocularis dnaJ subfamily B 0.1267 1 1
Echinococcus granulosus geminin 0.0516 0.4021 0.4014
Trypanosoma cruzi polo-like protein kinase, putative 0.0107 0.077 1
Trichomonas vaginalis CAMK family protein kinase 0.0107 0.077 0.3725
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0149 0.0723
Toxoplasma gondii histone lysine methyltransferase SET1 0.017 0.1269 0.278
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.021 0.2732
Schistosoma mansoni hypothetical protein 0.0032 0.0176 0.0174
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.021 0.2732
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0062 0.0411 0.041
Schistosoma mansoni glucose transport protein 0.0207 0.1562 0.1561
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0079 0.038
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.0022 0.0093 0.0453
Mycobacterium tuberculosis Conserved protein 0.0035 0.02 0.1165
Plasmodium falciparum calcium-dependent protein kinase 4 0.0064 0.0425 0.0613
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0107 0.077 0.076
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0149 0.0723
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0072 0.0493 0.6403
Giardia lamblia Hexose transporter 0.0029 0.0149 0.1826
Trypanosoma brucei THT1 - hexose transporter, putative 0.0064 0.0428 0.5558
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0067 0.0056
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0029 0.0149 0.3023
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0083 0.1079
Brugia malayi Sugar transporter family protein 0.0029 0.0149 0.0767
Trypanosoma brucei glucose transporter, putative 0.0064 0.0428 0.5558
Trichomonas vaginalis DNA polymerase eta, putative 0.0021 0.0083 0.0402
Loa Loa (eye worm) hypothetical protein 0.0102 0.0733 0.3997
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0046 0.0285 0.3703
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0062 0.0411 0.8323
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0099 0.0703 0.3827
Mycobacterium tuberculosis Conserved hypothetical protein 0.0021 0.0083 0.0483
Echinococcus multilocularis pyruvate kinase 0.0057 0.0373 0.0363
Trypanosoma brucei DNA polymerase eta, putative 0.0021 0.0083 0.1079
Plasmodium vivax calcium-dependent protein kinase, putative 0.0064 0.0425 0.0601
Plasmodium falciparum lysine--tRNA ligase 0.0046 0.0285 0.0411
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0099 0.0703 0.0701
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0029 0.0149 0.6946
Schistosoma mansoni ap endonuclease 0.0019 0.0067 0.0065
Loa Loa (eye worm) hypothetical protein 0.0029 0.0149 0.0767
Plasmodium falciparum protein kinase 7 0.0584 0.4566 0.6618
Onchocerca volvulus 0.0171 0.1279 0.5891
Echinococcus granulosus GPCR family 2 0.0032 0.0176 0.0166
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0083 0.1079
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0176 0.0166
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0021 0.0083 0.0483
Entamoeba histolytica hypothetical protein 0.0039 0.0226 0.2912
Toxoplasma gondii pyruvate kinase PyKII 0.0037 0.0214 0.0469
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0064 0.0424 0.2288
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.004 0.024 0.1161
Echinococcus multilocularis solute carrier family 22 0.0029 0.0149 0.0139
Trypanosoma cruzi hexose transporter, putative 0.0035 0.0197 0.2557
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.02 0.1165
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0067 0.2805
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.02 0.0969
Mycobacterium ulcerans lipase LipD 0.0035 0.02 0.4053
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0064 0.0424 0.2288
Trichomonas vaginalis CAMK family protein kinase 0.0107 0.077 0.3725
Trichomonas vaginalis pyruvate kinase, putative 0.0072 0.0494 0.2391
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0099 0.0703 0.0701
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.02 0.2601
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0207 0.1562 0.1553
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0032 0.0415
Onchocerca volvulus Pyruvate kinase homolog 0.0072 0.0494 0.1798
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.02 0.0199
Plasmodium falciparum hexose transporter 0.0207 0.1562 0.2263
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0149 0.0723
Schistosoma mansoni protein kinase 0.0064 0.0424 0.0423
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0176 0.0915
Schistosoma mansoni lysyl-tRNA synthetase 0.0046 0.0285 0.0283
Leishmania major pyruvate kinase 0.0072 0.0494 0.6419
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0149 0.0723
Entamoeba histolytica threonyl-tRNA synthetase, putative 0.0012 0.0011 0.0117
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0107 0.077 0.076
Toxoplasma gondii facilitative glucose transporter GT1 0.0207 0.1562 0.3422
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0149 0.0723
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.02 0.2601
Echinococcus granulosus pyruvate kinase 0.0072 0.0494 0.0484
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0149 0.0723
Brugia malayi Pyruvate kinase, M2 isozyme 0.0072 0.0494 0.2675
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0067 0.1351
Echinococcus granulosus calcium dependent protein kinase 0.0059 0.0391 0.038
Echinococcus granulosus pyruvate kinase 0.0037 0.0214 0.0203
Loa Loa (eye worm) hypothetical protein 0.0029 0.0149 0.0767
Schistosoma mansoni hypothetical protein 0.0516 0.4021 0.402
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0072 0.0493 0.6403
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0025 0.0121 0.0608
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0079 0.038
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0067 0.0388
Loa Loa (eye worm) hypothetical protein 0.0029 0.0149 0.0767
Brugia malayi hypothetical protein 0.0029 0.0149 0.0767
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0207 0.1562 0.1553
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0385 0.7788
Loa Loa (eye worm) pyruvate kinase-PB 0.005 0.032 0.1711
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0083 0.1079
Giardia lamblia Lysyl-tRNA synthetase 0.0046 0.0285 0.3614
Loa Loa (eye worm) hypothetical protein 0.0029 0.0149 0.0767
Schistosoma mansoni serine/threonine protein kinase 0.0107 0.077 0.0769
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0149 0.0723
Plasmodium vivax proline--tRNA ligase, putative 0.0072 0.0493 0.07
Echinococcus granulosus cpg binding protein 0.0094 0.0667 0.0656
Echinococcus multilocularis solute carrier family 22 0.0029 0.0149 0.0139
Brugia malayi serine/threonine-protein kinase plk-2 0.0107 0.077 0.4201
Toxoplasma gondii exonuclease III APE 0.0019 0.0067 0.0146
Brugia malayi hypothetical protein 0.0039 0.0226 0.1188
Loa Loa (eye worm) hypothetical protein 0.0029 0.0149 0.0767
Entamoeba histolytica protein kinase, putative 0.0064 0.0424 0.5499
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.02 0.1165
Onchocerca volvulus 0.0035 0.02 0.0266
Leishmania major DNA polymerase kappa, putative 0.0021 0.0083 0.1079
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.02 0.4053
Leishmania major glucose transporter, lmgt1 0.0064 0.0428 0.5558
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0062 0.0411 0.2217
Echinococcus multilocularis solute carrier family 22 0.0029 0.0149 0.0139
Echinococcus multilocularis GPCR, family 2 0.0032 0.0176 0.0166
Plasmodium vivax hypothetical protein, conserved 0.0035 0.02 0.0275
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0149 0.0723
Schistosoma mansoni hypothetical protein 0.0032 0.0176 0.0174
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0021 0.0083 0.0072
Toxoplasma gondii protein kinase, putative 0.0584 0.4566 1
Schistosoma mansoni lysyl-tRNA synthetase 0.0046 0.0285 0.0283
Trichomonas vaginalis conserved hypothetical protein 0.0207 0.1562 0.7556
Plasmodium falciparum threonine--tRNA ligase 0.0012 0.0011 0.0013
Brugia malayi Pre-SET motif family protein 0.0036 0.0203 0.1061
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0072 0.0494 0.2873
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0062 0.0411 0.0401
Onchocerca volvulus 0.0089 0.0626 0.2485
Trichomonas vaginalis sugar transport protein, putative 0.0029 0.0149 0.0723
Entamoeba histolytica hypothetical protein 0.0039 0.0226 0.2912
Brugia malayi Sugar transporter family protein 0.0207 0.1562 0.8582
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0064 0.0424 0.0414
Toxoplasma gondii threonyl-tRNA synthetase family protein 0.0012 0.0011 0.0024
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0083 0.1079
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0014 0.003 0.0028
Toxoplasma gondii transporter, major facilitator family protein 0.0029 0.0149 0.0327
Trypanosoma cruzi pyruvate kinase 2, putative 0.0072 0.0494 0.6419
Plasmodium vivax pyruvate kinase, putative 0.0072 0.0494 0.0702
Giardia lamblia Pyruvate kinase 0.0072 0.0494 0.6368
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0072 0.0493 0.6403
Brugia malayi Major Facilitator Superfamily protein 0.0029 0.0149 0.0767
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.02 0.019
Loa Loa (eye worm) sugar transporter 0.0029 0.0149 0.0767
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.002 0.0079 0.038
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0062 0.0411 0.2217
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0149 0.0723
Schistosoma mansoni hypothetical protein 0.007 0.0475 0.0474
Brugia malayi hypothetical protein 0.0029 0.0149 0.0767
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.0083 0.1681
Trichomonas vaginalis CAMK family protein kinase 0.0107 0.077 0.3725
Echinococcus granulosus histone lysine methyltransferase setb 0.0036 0.0203 0.0192
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0079 0.038
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.02 0.2601
Trichomonas vaginalis CAMK family protein kinase 0.0107 0.077 0.3725
Giardia lamblia Sugar-proton symporter 0.0029 0.0149 0.1826
Loa Loa (eye worm) histone methyltransferase 0.0029 0.0147 0.0755
Loa Loa (eye worm) hypothetical protein 0.0032 0.0176 0.0915
Loa Loa (eye worm) hypothetical protein 0.0062 0.0411 0.2217
Onchocerca volvulus Pyruvate kinase homolog 0.0072 0.0494 0.1798
Mycobacterium leprae conserved hypothetical protein 0.0035 0.02 0.4053
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0099 0.0703 0.0693
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0207 0.1562 0.1553
Plasmodium vivax pyruvate kinase 2, putative 0.0037 0.0214 0.0295
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0083 0.1079
Trypanosoma brucei glucose transporter, putative 0.0064 0.0428 0.5558
Loa Loa (eye worm) hypothetical protein 0.0035 0.02 0.1049
Brugia malayi pyruvate kinase, muscle isozyme 0.0015 0.004 0.016
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0207 0.1562 0.1553
Brugia malayi Cam kinase protein 1 0.0064 0.0424 0.2288
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0079 0.038
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0149 0.0723
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0064 0.0424 0.0414
Loa Loa (eye worm) pyruvate kinase 0.0015 0.004 0.016
Schistosoma mansoni pyruvate kinase 0.0072 0.0494 0.0493
Echinococcus multilocularis solute carrier family 22 0.0029 0.0149 0.0139
Plasmodium falciparum calcium-dependent protein kinase 1 0.0064 0.0425 0.0613
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0226 0.172 1
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0149 0.0723
Loa Loa (eye worm) hypothetical protein 0.005 0.0319 0.1705
Echinococcus granulosus dna polymerase eta 0.0021 0.0083 0.0072
Leishmania major hypothetical protein, conserved 0.0035 0.02 0.2601
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0083 0.04
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0176 0.0166
Brugia malayi Inositol-1 0.0037 0.021 0.1104
Leishmania major glucose transporter, lmgt3 0.0064 0.0428 0.5558
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0079 0.038
Treponema pallidum prolyl-tRNA synthetase 0.0022 0.0092 1
Brugia malayi Major Facilitator Superfamily protein 0.0029 0.0149 0.0767
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0207 0.1562 0.1553
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0083 0.1079
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0067 0.0323
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0149 0.0723
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0039 0.023 0.1336
Loa Loa (eye worm) hypothetical protein 0.0062 0.0411 0.2217
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0877 0.6896 0.6893
Schistosoma mansoni inositol monophosphatase 0.0037 0.021 0.0209
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0239 0.1819 1
Schistosoma mansoni serine/threonine protein kinase 0.0064 0.0424 0.0423
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.02 0.019
Entamoeba histolytica pyruvate kinase, putative 0.005 0.032 0.4142
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0149 0.0723
Brugia malayi F/Y-rich N-terminus family protein 0.0028 0.0144 0.0739
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0067 0.0056
Toxoplasma gondii ABC1 family protein 0.0035 0.02 0.0439
Schistosoma mansoni mixed-lineage leukemia protein mll 0.019 0.143 0.1428
Brugia malayi CXXC zinc finger family protein 0.0089 0.0626 0.3404
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0385 0.0383
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0083 0.1079
Trichomonas vaginalis pyruvate kinase, putative 0.0072 0.0494 0.2391
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0029 0.0149 0.0869
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0021 0.0083 0.04
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0203 0.0201
Loa Loa (eye worm) hypothetical protein 0.0029 0.0149 0.0767
Schistosoma mansoni protein kinase 0.0064 0.0424 0.0423
Loa Loa (eye worm) beta-lactamase 0.0035 0.02 0.1049
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0023 0.0104 0.0093
Plasmodium vivax hexose transporter 0.0207 0.1562 0.2253
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0083 0.1079
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0203 0.0201
Trypanosoma brucei glucose transporter, putative 0.0064 0.0428 0.5558
Schistosoma mansoni DNA polymerase eta 0.0021 0.0083 0.0081
Schistosoma mansoni ap endonuclease 0.0019 0.0067 0.0065
Echinococcus granulosus pyruvate kinase 0.0037 0.0214 0.0203
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0046 0.0285 0.3703
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0029 0.0147 0.0137
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0037 0.021 0.4256
Loa Loa (eye worm) hypothetical protein 0.0036 0.0203 0.1061
Giardia lamblia Kinase, PLK 0.0107 0.077 1
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0062 0.0411 0.041
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0079 0.038
Loa Loa (eye worm) pyruvate kinase 0.0072 0.0494 0.2675
Giardia lamblia Prolyl-tRNA synthetase 0.0062 0.0411 0.5276
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0023 0.0104 0.0093
Plasmodium falciparum pyruvate kinase 2 0.0037 0.0214 0.0308
Loa Loa (eye worm) hypothetical protein 0.0029 0.0149 0.0767
Brugia malayi Sugar transporter family protein 0.0029 0.0149 0.0767
Trypanosoma brucei unspecified product 0.0014 0.0032 0.0415
Loa Loa (eye worm) hypothetical protein 0.0171 0.1279 0.7018
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0067 0.0867
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0064 0.0424 0.0414
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.02 0.0969
Trypanosoma brucei pyruvate kinase 1, putative 0.0072 0.0494 0.6419
Trichomonas vaginalis CAMK family protein kinase 0.0107 0.077 0.3725
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0385 0.0383
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0149 0.0723
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0064 0.0425 0.093
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0064 0.0425 0.093
Schistosoma mansoni hypothetical protein 0.0039 0.0226 0.0224
Trypanosoma brucei glucose transporter, putative 0.0064 0.0428 0.5558
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0023 0.0104 0.0093
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.021 0.1018
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0011 0.0004 0.0021
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0083 0.1079
Mycobacterium tuberculosis Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase)(ThrRS) (threonine-tRNA ligase) 0.0012 0.0011 0.0063
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0149 0.0723
Brugia malayi Major Facilitator Superfamily protein 0.0029 0.0149 0.0767
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.0385 0.4999
Onchocerca volvulus 0.0035 0.02 0.0266
Plasmodium vivax SET domain protein, putative 0.0036 0.0203 0.0279
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0064 0.0424 0.0414
Echinococcus multilocularis pyruvate kinase 0.0072 0.0494 0.0484
Echinococcus granulosus solute carrier family 22 0.0029 0.0149 0.0139
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0067 0.0867
Trichomonas vaginalis esterase, putative 0.0035 0.02 0.0969
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0149 0.0723
Leishmania major pyruvate kinase 0.0072 0.0494 0.6419
Trypanosoma brucei glucose transporter 2A 0.0064 0.0428 0.5558
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0149 0.0723
Toxoplasma gondii pyruvate kinase PyK1 0.0072 0.0494 0.1083
Echinococcus multilocularis synaptic vesicle 2 protein 0.0029 0.0149 0.0139
Loa Loa (eye worm) hypothetical protein 0.0029 0.0149 0.0767
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0067 0.0094
Loa Loa (eye worm) hypothetical protein 0.0072 0.0494 0.2675
Plasmodium falciparum calcium-dependent protein kinase 5 0.0064 0.0425 0.0613
Giardia lamblia DINP protein human, muc B family 0.0021 0.0083 0.0953
Echinococcus multilocularis lysyl tRNA synthetase 0.0046 0.0285 0.0275
Schistosoma mansoni terminal deoxycytidyl transferase 0.0021 0.0083 0.0081
Loa Loa (eye worm) CXXC zinc finger family protein 0.0089 0.0626 0.3404
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0067 0.6853
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0079 0.038
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0067 0.0737
Plasmodium falciparum proline--tRNA ligase 0.0072 0.0493 0.0713
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.02 0.1165
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0149 0.0723
Schistosoma mansoni sugar transporter 0.0029 0.0149 0.0148
Trichomonas vaginalis glucose transporter, putative 0.0064 0.0428 0.2071
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0046 0.0285 0.5769
Trypanosoma brucei THT1 - hexose transporter, putative 0.0064 0.0428 0.5558
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0064 0.0424 0.0414
Mycobacterium ulcerans threonyl-tRNA synthetase 0.0012 0.0011 0.0218
Trypanosoma brucei glycyl-tRNA synthetase, putative 0.0012 0.0011 0.014
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.0083 0.1681
Loa Loa (eye worm) hypothetical protein 0.0029 0.0149 0.0767
Echinococcus multilocularis dna polymerase eta 0.0021 0.0083 0.0072
Leishmania major myo-inositol/proton symporter (MIT) 0.0029 0.0149 0.194
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0021 0.0083 0.0402
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0149 0.0723
Echinococcus granulosus solute carrier family 22 0.0029 0.0149 0.0139
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.02 0.1165
Brugia malayi hypothetical protein 0.0171 0.1279 0.7018
Echinococcus multilocularis calcium dependent protein kinase 0.0059 0.0391 0.038
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0149 0.0723
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0149 0.0723
Loa Loa (eye worm) hypothetical protein 0.0035 0.02 0.1049
Brugia malayi beta-lactamase 0.0035 0.02 0.1049
Echinococcus granulosus General substrate transporter 0.0178 0.1331 0.1322
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0102 0.0733 0.3997
Mycobacterium tuberculosis Conserved protein 0.0035 0.02 0.1165
Schistosoma mansoni hypothetical protein 0.0516 0.4021 0.402
Brugia malayi Pre-SET motif family protein 0.0238 0.1809 0.9945
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0149 0.0723
Loa Loa (eye worm) hypothetical protein 0.0035 0.02 0.1049
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0083 0.1079
Loa Loa (eye worm) inositol-1 0.0037 0.021 0.1104
Trypanosoma cruzi hexose transporter, putative 0.0064 0.0428 0.5558
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0149 0.0723
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0149 0.0723
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0067 0.031
Echinococcus granulosus solute carrier family 22 0.0029 0.0149 0.0139
Schistosoma mansoni hypothetical protein 0.0207 0.1562 0.1561
Plasmodium vivax lysine--tRNA ligase, putative 0.0046 0.0285 0.0398
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0037 0.021 0.0461
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0029 0.0149 0.0869
Entamoeba histolytica hypothetical protein 0.0039 0.0226 0.2912
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0067 0.0323
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0176 0.0166
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0334 0.2577 0.3727
Entamoeba histolytica serine/threonine protein kinase, putative 0.0107 0.077 1
Trypanosoma brucei sugar transporter, putative 0.0029 0.0149 0.194
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0079 0.038
Echinococcus multilocularis pyruvate kinase 0.0072 0.0494 0.0484
Entamoeba histolytica deoxycytidyl transferase, putative 0.0021 0.0083 0.1058
Entamoeba histolytica hypothetical protein 0.0039 0.0226 0.2912
Echinococcus granulosus solute carrier family 22 0.0029 0.0149 0.0139
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0029 0.0149 0.194
Onchocerca volvulus 0.027 0.2068 1
Plasmodium falciparum calcium-dependent protein kinase 3 0.0064 0.0425 0.0613
Mycobacterium ulcerans sugar transporter 0.0029 0.0149 0.3023
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.0203 0.0444
Trypanosoma brucei glucose transporter, putative 0.0064 0.0428 0.5558
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0067 0.0867
Echinococcus granulosus synaptic vesicle 2 protein 0.0029 0.0149 0.0139
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0012 0.0011 0.014
Leishmania major lysyl-tRNA synthetase, putative 0.0046 0.0285 0.3703
Trypanosoma cruzi pyruvate kinase 2, putative 0.0072 0.0494 0.6419
Brugia malayi Calcitonin receptor-like protein seb-1 0.0102 0.0733 0.3997
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0334 0.2577 0.5645
Trichomonas vaginalis helicase, putative 0.002 0.0079 0.038
Mycobacterium tuberculosis Conserved protein 0.0035 0.02 0.1165
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.002 0.0079 0.038
Trypanosoma brucei pyruvate kinase 1 0.0072 0.0494 0.6419
Giardia lamblia Pyruvate kinase 0.0037 0.0214 0.2676
Loa Loa (eye worm) hypothetical protein 0.0029 0.0149 0.0767
Trichomonas vaginalis sugar transporter, putative 0.0064 0.0428 0.2071
Schistosoma mansoni inositol monophosphatase 0.0037 0.021 0.0209
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0079 0.038
Loa Loa (eye worm) pyruvate kinase 0.0072 0.0494 0.2675
Schistosoma mansoni pyruvate kinase 0.0072 0.0494 0.0493
Loa Loa (eye worm) major facilitator superfamily transporter 0.0029 0.0149 0.0767
Mycobacterium leprae Probable lipase LipE 0.0035 0.02 0.4053
Loa Loa (eye worm) major facilitator superfamily transporter 0.0029 0.0149 0.0767
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0238 0.1809 0.9945
Loa Loa (eye worm) sugar transporter 0.0207 0.1562 0.8582
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0036 0.0203 0.0201
Schistosoma mansoni sugar transporter 0.0029 0.0149 0.0148
Toxoplasma gondii sugar transporter ST3 0.0029 0.0149 0.0327
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0079 0.038
Loa Loa (eye worm) hypothetical protein 0.0029 0.0149 0.0767
Schistosoma mansoni glucose transporter 0.0029 0.0149 0.0148
Mycobacterium leprae Probable pyruvate kinase PykA 0.0072 0.0494 1
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.0203 0.0192
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.02 0.1049
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.0385 0.2238
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0022 0.0092 0.1871
Trypanosoma brucei glucose transporter, putative 0.0064 0.0428 0.5558
Echinococcus multilocularis cpg binding protein 0.0094 0.0667 0.0656
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0072 0.0493 0.108
Loa Loa (eye worm) hypothetical protein 0.0021 0.0083 0.04
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0072 0.0493 0.6403
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0021 0.0083 0.1079
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0039 0.0226 0.0215
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0176 0.0166
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0149 0.0723
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0037 0.021 1
Schistosoma mansoni transcription factor LCR-F1 0.0039 0.0226 0.0224
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0033 0.018 0.3636
Loa Loa (eye worm) hypothetical protein 0.007 0.0475 0.257
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0149 0.0723
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0012 0.0011 0.014
Toxoplasma gondii sugar transporter ST1 0.0029 0.0149 0.0327
Trypanosoma cruzi hexose transporter 0.0064 0.0428 0.5558
Schistosoma mansoni hypothetical protein 0.1267 1 1
Chlamydia trachomatis proline--tRNA ligase 0.0022 0.0092 0.169
Onchocerca volvulus 0.0036 0.0203 0.0277
Plasmodium vivax sugar transporter, putative 0.0029 0.0149 0.0201
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0046 0.0285 0.5769
Plasmodium falciparum mitogen-activated protein kinase 2 0.0334 0.2577 0.3735
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.0385 0.0375
Entamoeba histolytica glycyl-tRNA synthetase, putative 0.0012 0.0011 0.0117
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0207 0.1562 0.1553
Echinococcus multilocularis inositol monophosphatase 1 0.0037 0.021 0.02
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0176 0.0915
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0099 0.0703 0.0693
Leishmania major DNA polymerase eta, putative 0.0021 0.0083 0.1079
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0083 0.1079
Brugia malayi lysyl-tRNA synthetase 0.0046 0.0285 0.1518
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0064 0.0424 0.0414
Trichomonas vaginalis set domain proteins, putative 0.027 0.2068 1
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.02 0.4053
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.02 0.1049
Trichomonas vaginalis glucose transporter, putative 0.0064 0.0428 0.2071
Trypanosoma cruzi glucose transporter, putative 0.0029 0.0149 0.194
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0046 0.0285 0.5769
Loa Loa (eye worm) hypothetical protein 0.005 0.032 0.1711
Schistosoma mansoni hypothetical protein 0.0032 0.0176 0.0174
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0149 0.0723
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0064 0.0425 0.0601
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0149 0.0723
Trichomonas vaginalis CAMK family protein kinase 0.0055 0.0356 0.1721
Loa Loa (eye worm) hypothetical protein 0.0029 0.0149 0.0767
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0064 0.0424 0.0414
Leishmania major glucose transporter/membrane transporter D2, putative 0.0064 0.0428 0.5558
Echinococcus multilocularis pyruvate kinase 0.0037 0.0214 0.0203
Toxoplasma gondii sugar transporter ST2 0.0029 0.0149 0.0327
Loa Loa (eye worm) hypothetical protein 0.0029 0.0149 0.0767
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0149 0.0723
Trypanosoma brucei threonyl-tRNA synthetase, putative 0.0012 0.0011 0.014
Mycobacterium ulcerans pyruvate kinase 0.0072 0.0494 1
Schistosoma mansoni kinase 0.0056 0.0367 0.0365
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0067 0.0081
Entamoeba histolytica protein kinase, putative 0.0064 0.0424 0.5499
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0036 0.0203 0.0192
Trichomonas vaginalis threonyl-tRNA synthetase, putative 0.0012 0.0011 0.0052
Loa Loa (eye worm) pyruvate kinase 0.0072 0.0494 0.2675
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0149 0.0723
Chlamydia trachomatis lysine--tRNA ligase 0.0046 0.0285 0.5675
Loa Loa (eye worm) hypothetical protein 0.0064 0.0424 0.2288
Toxoplasma gondii glycyl-tRNA synthetase 0.0012 0.0011 0.0024
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0102 0.0733 0.3997
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0004 0.0021
Loa Loa (eye worm) hypothetical protein 0.0029 0.0149 0.0767
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0064 0.0424 0.2288
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0064 0.0425 0.0601
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0062 0.0411 0.0401
Trypanosoma cruzi polo-like protein kinase, putative 0.0107 0.077 1
Trypanosoma cruzi hexose transporter, putative 0.0064 0.0428 0.5558
Trypanosoma brucei glucose transporter, putative 0.0064 0.0428 0.5558
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0149 0.0723
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0029 0.0149 0.0139
Loa Loa (eye worm) hypothetical protein 0.0035 0.02 0.1049
Echinococcus granulosus lysyl tRNA synthetase 0.0046 0.0285 0.0275
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.02 0.0969
Plasmodium falciparum protein kinase 6 0.0877 0.6898 1
Echinococcus granulosus pyruvate kinase 0.0072 0.0494 0.0484
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0064 0.0425 0.093
Schistosoma mansoni glycyl-tRNA synthetase 0.0012 0.0011 0.0009
Trichomonas vaginalis sugar transporter, putative 0.0064 0.0428 0.2071
Echinococcus multilocularis geminin 0.0516 0.4021 0.4014
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0064 0.0424 0.5509
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.02 0.0969
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0385 0.7788
Schistosoma mansoni sugar transporter 0.0029 0.0149 0.0148
Trypanosoma cruzi hexose transporter, putative 0.0029 0.0149 0.194
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0083 0.1079
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0029 0.0149 0.0148
Brugia malayi pyruvate kinase 0.0015 0.004 0.016
Echinococcus granulosus Sugar transporter ERD6 protein 0.0029 0.0149 0.0139
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0385 0.7788
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.02 0.1165
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0079 0.038
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0029 0.0147 0.0137
Trypanosoma brucei unspecified product 0.0014 0.0032 0.0415
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0083 0.04
Trichomonas vaginalis hypothetical protein 0.0011 0.0004 0.0021
Trypanosoma cruzi sugar transporter, putative 0.0029 0.0149 0.194
Trichomonas vaginalis myo-inositol transporter, putative 0.0029 0.0149 0.0723
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0099 0.0703 0.0701
Brugia malayi beta-lactamase family protein 0.0035 0.02 0.1049
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0149 0.0723
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0149 0.0723
Schistosoma mansoni protein kinase 0.0064 0.0424 0.0423
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0021 0.0083 0.0081
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0067 0.031
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0033 0.018 0.1045
Schistosoma mansoni cpg binding protein 0.0089 0.0626 0.0624
Brugia malayi beta-lactamase family protein 0.0035 0.02 0.1049
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0149 0.0723
Schistosoma mansoni hypothetical protein 0.0032 0.0176 0.0174
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0079 0.038
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0033 0.0177 0.0167
Schistosoma mansoni pyruvate kinase 0.0037 0.0214 0.0212
Echinococcus granulosus mixed lineage leukemia protein mll 0.0023 0.0104 0.0093
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0149 0.0723
Echinococcus multilocularis pyruvate kinase 0.0037 0.0214 0.0203
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0099 0.0703 0.0693
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0064 0.0425 0.0601
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0079 0.038
Trichomonas vaginalis inositol monophosphatase, putative 0.0037 0.021 0.1018
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0029 0.0149 0.0214
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0099 0.0703 0.3827
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0083 0.1079
Trypanosoma cruzi hexose transporter, putative 0.0064 0.0428 0.5558
Plasmodium vivax CDK-related protein kinase 6, putative 0.0877 0.6898 1
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0107 0.077 0.4201
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0079 0.038
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.0385 0.0843
Brugia malayi hypothetical protein 0.0029 0.0149 0.0767
Trichomonas vaginalis conserved hypothetical protein 0.0064 0.0428 0.2071
Trichomonas vaginalis glucose transporter, putative 0.0029 0.0149 0.0723
Leishmania major protein kinase, putative 0.0064 0.0424 0.5509
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0176 0.0915
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0067 0.0867
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.021 0.2732
Schistosoma mansoni glucose transport protein 0.0207 0.1562 0.1561
Mycobacterium ulcerans integral membrane transport protein 0.0029 0.0149 0.3023
Plasmodium falciparum pyruvate kinase 0.0072 0.0494 0.0714
Trypanosoma cruzi DNA polymerase eta, putative 0.0021 0.0083 0.1079
Onchocerca volvulus Serine\/threonine kinase homolog 0.0107 0.077 0.3236
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0032 0.0415
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0207 0.1562 0.1553

Activities

Activity type Activity value Assay description Source Reference
Inhibition (functional) = 0 % GSK_TCMDC: Percent inhibition of human HepG2 cell line. Test compounds present at 10uM. ChEMBL. 20485427
Inhibition (functional) = 0 % GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 LDH activity, using an LDH reporter assay. Test compounds present at 2uM ChEMBL. 20485427
Inhibition (functional) = 1.7 % ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGLUT1 that are glucose transport deficient and complemented with the human glucose transporter GLUT1. Activity is measured by DNA content using SYBR green in vitro ChEMBL. No reference
Inhibition (functional) = 1.76 % ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmPfHT that are glucose transport deficient and complemented with the Plasmodium falciparum hexose transporter. Activity is measured by by DNA content using SYBR green in vitro ChEMBL. No reference
Inhibition (functional) = 2.94 % ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGT2 that are glucose transport deficient and complemented with the L. Mexicana glucose transporter 2. Activity is measured by by DNA content using SYBR green in vitro ChEMBL. No reference
Inhibition (functional) = 54 % GSK_TCMDC: Inhibition of Plasmodium falciparum Dd2 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM ChEMBL. 20485427
Inhibition (functional) = 90 % GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM ChEMBL. 20485427
Inhibition frequency index (IFI) (functional) = 0.85 Inhibition Frequency Index (IFI) GSK. 20485427
Percent growth inhibition (functional) = -4 % Percent inhibition of HepG2 growth (at 10 uM) GSK. 20485427
Percent growth inhibition (functional) = -2 % Percent inhibition of P. falciparum lactate dehydrogenase activity (at 2 uM) GSK. 20485427
Percent growth inhibition (functional) = 54 % Percent inhibition of P. falciparum Dd2 growth (at 2 uM) GSK. 20485427
Percent growth inhibition (functional) = 90 % Percent inhibition of P. falciparum 3D7 growth (at 2 uM) GSK. 20485427
XC50 (functional) = 6.42 XC50 determination of P. falciparum 3D7 growth GSK. 20485427
XC50 (functional) = 0.38092 uM GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole erythrocytes, using parasite LDH activity as an index of growth. ChEMBL. 20485427

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.