TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 478.489 | Formula: C25H17F3N4OS
H donors: 3 H acceptors: 2 LogP: 5.9 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: O=C(Nc1cscc1)Nc1cccc(c1)c1ccc(cc1)c1nc2c([nH]1)ccc(c2)C(F)(F)F
InChi: 1S/C25H17F3N4OS/c26-25(27,28)18-8-9-21-22(13-18)32-23(31-21)16-6-4-15(5-7-16)17-2-1-3-19(12-17)29-24(33)30-20-10-11-34-14-20/h1-14H,(H,31,32)(H2,29,30,33)
InChiKey: ZRZUPCZNRMPARA-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0031	0.0024	0.0024
Loa Loa (eye worm)	hypothetical protein	0.0227	0.0974	0.0974
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0081	0.0269	0.0269
Echinococcus multilocularis	receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type	0.0081	0.0269	0.0255
Echinococcus granulosus	receptor type tyrosine protein phosphatase zeta	0.0091	0.0314	0.03
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0081	0.0269	0.0269
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0269	0.0269
Echinococcus granulosus	receptor type tyrosine protein phosphatase zeta	0.0081	0.0269	0.0255
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0081	0.0269	0.0255
Schistosoma mansoni	ectonucleotide pyrophosphatase/phosphodiesterase	0.0067	0.02	0.0186
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0031	0.0024	0.001
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.2091	1	1
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0081	0.0269	0.0269
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0014	0.0014
Brugia malayi	hypothetical protein	0.0126	0.0484	0.0484
Loa Loa (eye worm)	hypothetical protein	0.0146	0.0581	0.0581
Schistosoma mansoni	hypothetical protein	0.0354	0.1588	0.1576
Loa Loa (eye worm)	protein-tyrosine phosphatase 1	0.0081	0.0269	0.0269
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0269	0.0269
Trypanosoma cruzi	DNA/RNA non-specific endonuclease protein-like, putative	0.004	0.007	0.1019
Trypanosoma cruzi	endonuclease G, putative	0.004	0.007	0.1019
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0081	0.0269	0.0269
Loa Loa (eye worm)	oxidoreductase	0.0031	0.0024	0.0024
Echinococcus granulosus	ectonucleotide pyrophosphatase:phosphodiesterase	0.0056	0.0149	0.0135
Brugia malayi	Thrombospondin type 1 domain containing protein	0.0145	0.0576	0.0576
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0091	0.0314	0.03
Echinococcus granulosus	Receptor type tyrosine protein phosphatase O	0.0081	0.0269	0.0255
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0269	0.0269
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0269	0.0269
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0031	0.0024	0.001
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0081	0.0269	0.0255
Giardia lamblia	Protein tyrosine phosphatase	0.0081	0.0269	0.098
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0081	0.0269	0.0255
Echinococcus granulosus	aldo keto reductase	0.0031	0.0024	0.001
Echinococcus granulosus	protein tyrosine phosphatase n9	0.0081	0.0269	0.0255
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0081	0.0269	0.0269
Echinococcus granulosus	aldo keto reductase	0.0031	0.0024	0.001
Mycobacterium ulcerans	oxidoreductase	0.0031	0.0024	0.0095
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0081	0.0269	0.0269
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.0081	0.0269	0.098
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0031	0.0024	0.0024
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0081	0.0269	0.0255
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0031	0.0024	0.001
Schistosoma mansoni	protein-tyrosine phosphatase non-receptor type nt5	0.0081	0.0269	0.0255
Schistosoma mansoni	ectonucleotide pyrophosphatase/phosphodiesterase	0.0067	0.02	0.0186
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0269	0.0269
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.0546	0.2521	1
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0081	0.0269	0.0255
Onchocerca volvulus		0.0067	0.02	0.0741
Onchocerca volvulus		0.0081	0.0269	0.1015
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0081	0.0269	0.0255
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0081	0.0269	0.0269
Trypanosoma brucei	low molecular weight protein tyrosine phosphatase, putative	0.0168	0.0691	1
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0081	0.0269	0.0269
Schistosoma mansoni	hypothetical protein	0.0354	0.1588	0.1576
Echinococcus granulosus	ectonucleotide pyrophosphatase:phosphodiesterase	0.0067	0.02	0.0186
Onchocerca volvulus		0.0081	0.0269	0.1015
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0269	0.0269
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0269	0.0269
Onchocerca volvulus		0.0031	0.0024	0.004
Schistosoma mansoni	hypothetical protein	0.0145	0.0576	0.0563
Leishmania major	DNA/RNA non-specific endonuclease-like protein	0.004	0.007	0.1019
Brugia malayi	Intermediate filament tail domain containing protein	0.0029	0.0014	0.0014
Echinococcus granulosus	Receptor type tyrosine protein phosphatase O	0.0081	0.0269	0.0255
Toxoplasma gondii	DNA/RNA non-specific endonuclease	0.004	0.007	1
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0031	0.0024	0.0024
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0081	0.0269	0.0269
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0031	0.0024	0.001
Onchocerca volvulus		0.0081	0.0269	0.1015
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0031	0.0024	0.001
Echinococcus granulosus	ectonucleotide pyrophosphatase:phosphodiesterase	0.0067	0.02	0.0186
Echinococcus multilocularis	ectonucleotide pyrophosphatase:phosphodiesterase	0.0067	0.02	0.0186
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0269	0.0269
Brugia malayi	intermediate filament protein	0.0029	0.0014	0.0014
Loa Loa (eye worm)	dual specificity protein phosphatase CDC14B	0.0081	0.0269	0.0269
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0031	0.0024	0.001
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0081	0.0269	0.0269
Echinococcus granulosus	hypothetical protein	0.0031	0.0024	0.001
Echinococcus granulosus	Endonuclease G	0.004	0.007	0.0056
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0081	0.0269	0.0269
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0031	0.0024	0.001
Schistosoma mansoni	endonuclease related	0.004	0.007	0.0056
Loa Loa (eye worm)	thrombospondin type 1 domain-containing protein	0.0145	0.0576	0.0576
Echinococcus multilocularis	Endonuclease G	0.004	0.007	0.0056
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0269	0.0269
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.0546	0.2521	1
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.0546	0.2521	1
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0081	0.0269	0.0255
Onchocerca volvulus		0.0081	0.0269	0.1015
Trypanosoma cruzi	tyrosine specific protein phosphatase, putative	0.0081	0.0269	0.3887
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0081	0.0269	0.0269
Schistosoma mansoni	hypothetical protein	0.0035	0.0045	0.0031
Echinococcus granulosus	ectonucleotide	0.0056	0.0149	0.0135
Onchocerca volvulus		0.0031	0.0024	0.004
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0269	0.0269
Trypanosoma brucei	aldo-keto reductase, putative	0.0031	0.0024	0.0347
Loa Loa (eye worm)	protein-tyrosine-phosphatase	0.0081	0.0269	0.0269
Onchocerca volvulus		0.0067	0.02	0.0741
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0081	0.0269	0.0255
Echinococcus multilocularis	ectonucleotide pyrophosphatase:phosphodiesterase	0.0067	0.02	0.0186
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0031	0.0024	0.001
Brugia malayi	hypothetical protein	0.0037	0.0054	0.0054
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0081	0.0269	0.0255
Brugia malayi	Type I phosphodiesterase / nucleotide pyrophosphatase family protein	0.0067	0.02	0.02
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0081	0.0269	0.0269
Trypanosoma brucei	prostaglandin f synthase	0.0031	0.0024	0.0347
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0031	0.0024	0.001
Onchocerca volvulus		0.0155	0.0627	0.2443
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0081	0.0269	0.0269
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0024	0.0024
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0081	0.0269	0.0269
Onchocerca volvulus		0.0081	0.0269	0.1015
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0031	0.0024	0.001
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0081	0.0269	0.0255
Echinococcus multilocularis	receptor type tyrosine protein phosphatase zeta	0.0081	0.0269	0.0255
Schistosoma mansoni	receptor protein tyrosine phosphatase	0.0091	0.0314	0.03
Onchocerca volvulus		0.0145	0.0576	0.2241
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0051	0.0123	0.0123
Leishmania major	tyrosine specific protein phosphatase, putative	0.0081	0.0269	0.3887
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0269	0.0269
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0081	0.0269	0.0255
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0269	0.0269
Echinococcus granulosus	geminin	0.0354	0.1588	0.1576
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.0546	0.2521	1
Echinococcus granulosus	ectonucleotide pyrophosphatase:phosphodiesterase	0.0067	0.02	0.0186
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0081	0.0269	0.0269
Loa Loa (eye worm)	phosphotyrosine protein phosphatase	0.0546	0.2521	0.2521
Loa Loa (eye worm)	oxidoreductase	0.0031	0.0024	0.0024
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0091	0.0314	0.03
Echinococcus granulosus	ectonucleotide pyrophosphatase:phosphodiesterase	0.0067	0.02	0.0186
Loa Loa (eye worm)	protein tyrosine phosphatase	0.0081	0.0269	0.0269
Onchocerca volvulus		0.0081	0.0269	0.1015
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0269	0.0269
Trypanosoma cruzi	hypothetical protein, conserved	0.0168	0.0691	1
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0081	0.0269	0.0269
Loa Loa (eye worm)	hypothetical protein	0.0067	0.02	0.02
Trypanosoma cruzi	DNA/RNA non-specific endonuclease protein-like, putative	0.004	0.007	0.1019
Brugia malayi	Protein-tyrosine phosphatase 1	0.0081	0.0269	0.0269
Schistosoma mansoni	ectonucleotide pyrophosphatase/phosphodiesterase	0.0067	0.02	0.0186
Leishmania major	hypothetical protein, conserved	0.0168	0.0691	1
Entamoeba histolytica	Pten 3-phosphoinositide phosphatase, putative	0.0081	0.0269	0.098
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0081	0.0269	0.0269
Entamoeba histolytica	hypothetical protein	0.0037	0.0054	0.0121
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0269	0.0269
Echinococcus multilocularis	receptor type tyrosine protein phosphatase zeta	0.0091	0.0314	0.03
Onchocerca volvulus		0.0081	0.0269	0.1015
Loa Loa (eye worm)	oxidoreductase	0.0031	0.0024	0.0024
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0091	0.0314	0.03
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0091	0.0314	0.03
Echinococcus multilocularis	receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type	0.0091	0.0314	0.03
Trypanosoma cruzi	tyrosine specific protein phosphatase, putative	0.0081	0.0269	0.3887
Brugia malayi	protein-tyrosine phosphatase Lar-like precursor, putative	0.0081	0.0269	0.0269
Brugia malayi	endonuclease G, mitochondrial precursor	0.004	0.007	0.007
Echinococcus multilocularis	aldo keto reductase	0.0031	0.0024	0.001
Schistosoma mansoni	receptor protein tyrosine phosphatase n (ia2)	0.0081	0.0269	0.0255
Trypanosoma brucei	protein tyrosine phosphatase 1	0.0081	0.0269	0.3887
Brugia malayi	Dual specificity protein phosphatase CDC14B	0.0081	0.0269	0.0269
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.0168	0.0691	0.2671
Brugia malayi	Protein-tyrosine phosphatase	0.0081	0.0269	0.0269
Brugia malayi	hypothetical protein	0.0081	0.0269	0.0269
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0269	0.0269
Loa Loa (eye worm)	hypothetical protein	0.0126	0.0484	0.0484
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0269	0.0269
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0149	0.0149
Schistosoma mansoni	receptor protein tyrosine phosphatase r (pcptp1)	0.0081	0.0269	0.0255
Echinococcus multilocularis	geminin	0.0354	0.1588	0.1576
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0031	0.0024	0.0024
Brugia malayi	hypothetical protein	0.0081	0.0269	0.0269
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0031	0.0024	0.001
Giardia lamblia	Low molecular weight protein-tyrosine-phosphatase	0.0546	0.2521	1
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0081	0.0269	0.0269
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0031	0.0024	0.001
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0091	0.0314	0.03
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0081	0.0269	0.0269
Loa Loa (eye worm)	intermediate filament protein	0.0029	0.0014	0.0014
Onchocerca volvulus		0.0081	0.0269	0.1015
Trypanosoma cruzi	aldo-keto reductase	0.0031	0.0024	0.0347
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0081	0.0269	0.0255
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.0546	0.2521	1
Brugia malayi	hypothetical protein	0.0081	0.0269	0.0269
Brugia malayi	Low molecular weight phosphotyrosine protein phosphatase containing protein	0.0546	0.2521	0.2521
Trypanosoma cruzi	endonuclease G, putative	0.004	0.007	0.1019
Leishmania major	prostaglandin f synthase, putative	0.0031	0.0024	0.0347
Echinococcus multilocularis	aldo keto reductase	0.0031	0.0024	0.001
Schistosoma mansoni	aldo-keto reductase	0.0031	0.0024	0.001
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0091	0.0314	0.03
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0081	0.0269	0.0255
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0269	0.0269
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0081	0.0269	0.0269
Leishmania major	protein-tyrosine phosphatase 1-like protein	0.0081	0.0269	0.3887
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0029	0.0014	0.0014
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0081	0.0269	0.0269
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0081	0.0269	0.0255
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.2091	1	1
Onchocerca volvulus		0.0081	0.0269	0.1015
Schistosoma mansoni	protein tyrosine phosphatase	0.0081	0.0269	0.0255
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0081	0.0269	0.0255
Loa Loa (eye worm)	oxidoreductase	0.0031	0.0024	0.0024
Onchocerca volvulus		0.0081	0.0269	0.1015
Echinococcus granulosus	ectonucleotide pyrophosphatase:phosphodiesterase	0.0067	0.02	0.0186
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0269	0.0269
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0031	0.0024	0.001
Schistosoma mansoni	protein tyrosine phosphatase	0.0081	0.0269	0.0255
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0081	0.0269	0.0269
Schistosoma mansoni	ectonucleotide pyrophosphatase/phosphodiesterase	0.0067	0.02	0.0186
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0081	0.0269	0.0255
Echinococcus multilocularis	receptor type tyrosine protein phosphatase F	0.0091	0.0314	0.03
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0081	0.0269	0.0269
Brugia malayi	Protein-tyrosine phosphatase	0.0236	0.102	0.102
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0123	0.0123
Brugia malayi	hypothetical protein	0.0081	0.0269	0.0269
Loa Loa (eye worm)	cytochrome P450 family protein	0.0054	0.0138	0.0138
Echinococcus multilocularis	receptor type tyrosine protein phosphatase H	0.0081	0.0269	0.0255
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0031	0.0024	0.001
Echinococcus multilocularis	protein tyrosine phosphatase n9	0.0081	0.0269	0.0255
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0081	0.0269	0.0255
Onchocerca volvulus		0.0081	0.0269	0.1015
Trypanosoma cruzi	hypothetical protein, conserved	0.0168	0.0691	1
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0081	0.0269	0.0255
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0081	0.0269	0.0255
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0081	0.0269	0.0269
Onchocerca volvulus		0.0081	0.0269	0.1015
Trypanosoma cruzi	tyrosine specific protein phosphatase, putative	0.0081	0.0269	0.3887
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0081	0.0269	0.0255
Trypanosoma cruzi	aldo/keto reductase, putative	0.0031	0.0024	0.0347
Leishmania major	aldehyde reductase, putative,oxidoreductase, putative	0.0031	0.0024	0.0347
Echinococcus multilocularis	ectonucleotide pyrophosphatase:phosphodiesterase	0.0056	0.0149	0.0135
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0081	0.0269	0.0269
Onchocerca volvulus		0.0031	0.0024	0.004
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0269	0.0269
Mycobacterium ulcerans	phosphotyrosine protein phosphatase PtpA	0.0546	0.2521	1
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0051	0.0123	0.0123
Onchocerca volvulus		0.0081	0.0269	0.1015
Schistosoma mansoni	protein tyrosine phosphatase non-receptor type nt1	0.2091	1	1
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0269	0.0269
Schistosoma mansoni	pcd6 interacting protein-related	0.0081	0.0269	0.0255
Onchocerca volvulus		0.0546	0.2521	1
Trichomonas vaginalis	low molecular weight protein-tyrosine-phosphatase, putative	0.0546	0.2521	1
Onchocerca volvulus		0.0081	0.0269	0.1015
Onchocerca volvulus		0.0081	0.0269	0.1015
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0081	0.0269	0.0269
Onchocerca volvulus		0.0081	0.0269	0.1015
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0081	0.0269	0.0269
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0081	0.0269	0.0269
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0037	0.0054	0.004
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0081	0.0269	0.0269
Onchocerca volvulus	4.1 G protein, putative homolog	0.0081	0.0269	0.1015
Leishmania major	prostaglandin f2-alpha synthase/D-arabinose dehydrogenase	0.0031	0.0024	0.0347
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0081	0.0269	0.0269
Schistosoma mansoni	transcription factor LCR-F1	0.0037	0.0054	0.004
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0037	0.0054	0.004
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0081	0.0269	0.0269
Trypanosoma brucei	endonuclease G, putative	0.004	0.007	0.1019
Schistosoma mansoni	hypothetical protein	0.0037	0.0054	0.004
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0269	0.0269
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0031	0.0024	0.001
Loa Loa (eye worm)	fibronectin type III domain-containing protein	0.0091	0.0314	0.0314
Leishmania major	endonuclease G, putative	0.004	0.007	0.1019
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0081	0.0269	0.0269
Onchocerca volvulus		0.0081	0.0269	0.1015
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0031	0.0024	0.001
Onchocerca volvulus		0.0031	0.0024	0.004
Mycobacterium tuberculosis	Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase)	0.0378	0.1706	1
Brugia malayi	Cytochrome P450 family protein	0.0054	0.0138	0.0138
Echinococcus multilocularis	aldo keto reductase	0.0031	0.0024	0.001
Schistosoma mansoni	pol-related	0.0031	0.0024	0.001
Loa Loa (eye worm)	oxidoreductase	0.0031	0.0024	0.0024
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0091	0.0314	0.03
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0081	0.0269	0.0269
Echinococcus multilocularis	aldo keto reductase	0.0031	0.0024	0.001
Entamoeba histolytica	hypothetical protein	0.0037	0.0054	0.0121
Echinococcus multilocularis	ectonucleotide pyrophosphatase:phosphodiesterase	0.0067	0.02	0.0186
Onchocerca volvulus		0.0081	0.0269	0.1015
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0091	0.0314	0.03
Schistosoma mansoni	receptor protein tyrosine phosphatase n (ia2)	0.0081	0.0269	0.0255
Echinococcus multilocularis	ectonucleotide pyrophosphatase:phosphodiesterase	0.0067	0.02	0.0186
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0081	0.0269	0.0255
Onchocerca volvulus		0.0031	0.0024	0.004
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0091	0.0314	0.03
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0269	0.0269
Schistosoma mansoni	rgs-gaip interacting protein gipc	0.0081	0.0269	0.0255
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0031	0.0024	0.001
Onchocerca volvulus		0.0031	0.0024	0.004
Onchocerca volvulus		0.0081	0.0269	0.1015
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0269	0.0269
Echinococcus multilocularis	ectonucleotide pyrophosphatase:phosphodiesterase	0.0067	0.02	0.0186
Brugia malayi	hypothetical protein	0.0081	0.0269	0.0269
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0091	0.0314	0.03
Echinococcus multilocularis	ectonucleotide	0.0056	0.0149	0.0135
Entamoeba histolytica	hypothetical protein	0.0037	0.0054	0.0121
Mycobacterium leprae	PROBABLE OXIDOREDUCTASE	0.0031	0.0024	0.5
Schistosoma mansoni	aldo-keto reductase	0.0031	0.0024	0.001
Onchocerca volvulus		0.0081	0.0269	0.1015
Schistosoma mansoni	non-receptor protein-tyrosine phosphatase	0.0081	0.0269	0.0255
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.0168	0.0691	0.2671
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0081	0.0269	0.0269
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0045	0.0045
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0031	0.0024	0.001
Brugia malayi	latrophilin 2 splice variant baaae	0.0035	0.0045	0.0045
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0051	0.0123	0.0123
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0081	0.0269	0.0255
Onchocerca volvulus		0.0081	0.0269	0.1015
Trypanosoma brucei	endonuclease G, putative	0.004	0.007	0.1019
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0031	0.0024	0.001
Echinococcus multilocularis	hypothetical protein	0.0081	0.0269	0.0255
Loa Loa (eye worm)	hypothetical protein	0.0067	0.02	0.02
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0269	0.0269
Trichomonas vaginalis	pten, drome, putative	0.0081	0.0269	0.098
Leishmania major	aldo-keto reductase-like protein	0.0031	0.0024	0.0347
Loa Loa (eye worm)	hypothetical protein	0.0126	0.0484	0.0484
Onchocerca volvulus	Huntingtin homolog	0.0126	0.0484	0.1876
Echinococcus multilocularis		0.0081	0.0269	0.0255
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.2091	1	1
Onchocerca volvulus		0.0081	0.0269	0.1015
Entamoeba histolytica	hypothetical protein	0.0037	0.0054	0.0121
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0081	0.0269	0.0269
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0012	0.0012
Echinococcus multilocularis	ectonucleotide pyrophosphatase:phosphodiesterase	0.0067	0.02	0.0186
Onchocerca volvulus		0.0081	0.0269	0.1015
Loa Loa (eye worm)	hypothetical protein	0.0067	0.02	0.02
Echinococcus granulosus	aldo keto reductase	0.0031	0.0024	0.001
Loa Loa (eye worm)	hypothetical protein	0.0146	0.0581	0.0581
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0081	0.0269	0.0255
Trichomonas vaginalis	low molecular weight protein-tyrosine-phosphatase, putative	0.0546	0.2521	1
Loa Loa (eye worm)	hypothetical protein	0.0146	0.0581	0.0581
Onchocerca volvulus	Huntingtin homolog	0.0126	0.0484	0.1876
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0031	0.0024	0.001
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0269	0.0269
Schistosoma mansoni	protein-tyrosine phosphatase n9	0.0081	0.0269	0.0255
Trypanosoma brucei	endonuclease G, putative	0.004	0.007	0.1019
Schistosoma mansoni	protein tyrosine phosphatase	0.0091	0.0314	0.03
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.0081	0.0269	0.098
Trichomonas vaginalis	low molecular weight protein-tyrosine-phosphatase, putative	0.0546	0.2521	1

Activities

Activity type	Activity value	Assay description	Source	Reference
Inhibition (functional)	= 0 %	GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 LDH activity, using an LDH reporter assay. Test compounds present at 2uM	ChEMBL.	20485427
Inhibition (functional)	= 6.27 %	ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmPfHT that are glucose transport deficient and complemented with the Plasmodium falciparum hexose transporter. Activity is measured by by DNA content using SYBR green in vitro	ChEMBL.	No reference
Inhibition (functional)	= 6.66 %	ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGLUT1 that are glucose transport deficient and complemented with the human glucose transporter GLUT1. Activity is measured by DNA content using SYBR green in vitro	ChEMBL.	No reference
Inhibition (functional)	= 7.95 %	ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGT2 that are glucose transport deficient and complemented with the L. Mexicana glucose transporter 2. Activity is measured by by DNA content using SYBR green in vitro	ChEMBL.	No reference
Inhibition (functional)	= 36 %	GSK_TCMDC: Inhibition of Plasmodium falciparum Dd2 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM	ChEMBL.	20485427
Inhibition (functional)	= 45 %	GSK_TCMDC: Percent inhibition of human HepG2 cell line. Test compounds present at 10uM.	ChEMBL.	20485427
Inhibition (functional)	= 99 %	GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM	ChEMBL.	20485427
Inhibition frequency index (IFI) (functional)	= 5.88	Inhibition Frequency Index (IFI)	GSK.	20485427
Percent growth inhibition (functional)	= -2 %	Percent inhibition of P. falciparum lactate dehydrogenase activity (at 2 uM)	GSK.	20485427
Percent growth inhibition (functional)	= 36 %	Percent inhibition of P. falciparum Dd2 growth (at 2 uM)	GSK.	20485427
Percent growth inhibition (functional)	= 45 %	Percent inhibition of HepG2 growth (at 10 uM)	GSK.	20485427
Percent growth inhibition (functional)	= 99 %	Percent inhibition of P. falciparum 3D7 growth (at 2 uM)	GSK.	20485427
XC50 (functional)	= 6.46	XC50 determination of P. falciparum 3D7 growth	GSK.	20485427
XC50 (functional)	= 0.35056 uM	GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole erythrocytes, using parasite LDH activity as an index of growth.	ChEMBL.	20485427

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL548801
Search by GSK

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 598538