Detailed information for compound 618848

Basic information

Technical information
  • TDR Targets ID: 618848
  • Name: 4-[5-(2,4-dichlorophenyl)-3-(4-methoxyphenyl) -4,5-dihydropyrazol-1-yl]-4-oxobutanoic acid
  • MW: 421.274 | Formula: C20H18Cl2N2O4
  • H donors: 1 H acceptors: 3 LogP: 3.36 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)C1=NN(C(C1)c1ccc(cc1Cl)Cl)C(=O)CCC(=O)O
  • InChi: 1S/C20H18Cl2N2O4/c1-28-14-5-2-12(3-6-14)17-11-18(15-7-4-13(21)10-16(15)22)24(23-17)19(25)8-9-20(26)27/h2-7,10,18H,8-9,11H2,1H3,(H,26,27)
  • InChiKey: LLRALJXJPWATKY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-[5-(2,4-dichlorophenyl)-3-(4-methoxyphenyl)-4,5-dihydropyrazol-1-yl]-4-oxo-butanoic acid
  • 4-[5-(2,4-dichlorophenyl)-3-(4-methoxyphenyl)-4,5-dihydropyrazol-1-yl]-4-keto-butyric acid
  • ChemDiv1_007201

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi metacaspase, putative 0.0027 0.0036 0.1996
Mycobacterium ulcerans beta-lactamase 0.0037 0.0094 0.002
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0036 0.0086 0.107
Onchocerca volvulus 0.0037 0.0094 0.103
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0122 0.0596 0.1395
Leishmania major hypothetical protein, conserved 0.0037 0.0094 0.1522
Loa Loa (eye worm) hypothetical protein 0.0091 0.0414 0.1112
Echinococcus granulosus sentrin specific protease 7 0.0153 0.0775 0.1967
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0094 0.5545
Mycobacterium tuberculosis Probable lipase LipE 0.0037 0.0094 0.0096
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0036 0.0086 0.5076
Mycobacterium ulcerans acyl-CoA synthetase 0.0122 0.0596 0.1328
Trypanosoma brucei metacaspase MCA2 0.0027 0.0036 0.1406
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0091 0.0414 0.0923
Plasmodium vivax hypothetical protein, conserved 0.0027 0.0036 0.0791
Mycobacterium tuberculosis Probable hydrolase 0.0037 0.0094 0.0096
Mycobacterium tuberculosis Probable esterase LipL 0.0037 0.0094 0.0096
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0091 0.0414 0.5
Plasmodium vivax acetyl-CoA synthetase, putative 0.0036 0.0086 0.2013
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.0153 0.1672
Brugia malayi AMP-binding enzyme family protein 0.0036 0.0086 0.0923
Trypanosoma brucei metacaspase 5, putative 0.0027 0.0036 0.1406
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0037 0.0094 0.002
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0094 0.5545
Echinococcus granulosus fetal alzheimer antigen falz 0.0023 0.0012 0.0021
Onchocerca volvulus 0.0036 0.0086 0.0894
Loa Loa (eye worm) hypothetical protein 0.0037 0.0092 0.0247
Plasmodium falciparum importin beta, putative 0.0061 0.0234 0.5627
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0027 0.0036 0.1996
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0036 0.0086 0.3578
Entamoeba histolytica acyl-coA synthetase, putative 0.0122 0.0596 0.768
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0036 0.1996
Loa Loa (eye worm) hypothetical protein 0.0091 0.0414 0.1112
Echinococcus multilocularis importin subunit beta 1 0.0061 0.0234 0.0231
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0037 0.0093 0.0229
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0122 0.0596 0.1328
Loa Loa (eye worm) hypothetical protein 0.0037 0.0094 0.0252
Echinococcus granulosus caspase 0.0103 0.0479 0.1214
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0036 0.0086 0.0076
Brugia malayi latrophilin 2 splice variant baaae 0.0037 0.0092 0.0987
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0153 0.0412
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0036 0.0086 0.5076
Schistosoma mansoni caspase-7 (C14 family) 0.0027 0.0036 0.0097
Mycobacterium leprae conserved hypothetical protein 0.0037 0.0094 0.0082
Toxoplasma gondii ABC1 family protein 0.0037 0.0094 0.3908
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.0153 0.0412
Trypanosoma cruzi metacaspase 5, putative 0.0027 0.0036 0.1996
Plasmodium vivax metacaspase 1, putative 0.0027 0.0036 0.0791
Leishmania major importin beta-1 subunit, putative 0.005 0.0166 0.2744
Entamoeba histolytica hypothetical protein 0.005 0.0166 0.2108
Loa Loa (eye worm) hypothetical protein 0.0037 0.0094 0.0252
Mycobacterium ulcerans hypothetical protein 0.0037 0.0094 0.002
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0153 0.0381
Trichomonas vaginalis antibiotic synthetase, putative 0.0036 0.0086 0.5076
Loa Loa (eye worm) hypothetical protein 0.0036 0.0086 0.0232
Trypanosoma brucei importin beta-1 subunit, putative 0.0061 0.0234 1
Echinococcus granulosus geminin 0.0175 0.0907 0.2305
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0027 0.0036 0.0097
Loa Loa (eye worm) hypothetical protein 0.0122 0.0596 0.1603
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0122 0.0596 0.1395
Toxoplasma gondii HEAT repeat-containing protein 0.0061 0.0234 1
Leishmania major metacaspase, putative 0.0027 0.0036 0.0548
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0036 0.1996
Schistosoma mansoni caspase-7 (C14 family) 0.0103 0.0479 0.129
Schistosoma mansoni caspase-3 (C14 family) 0.0103 0.0479 0.129
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0094 0.5545
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0027 0.0036 0.1996
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0103 0.0479 0.1214
Loa Loa (eye worm) hypothetical protein 0.0042 0.0123 0.033
Mycobacterium tuberculosis Probable thymidine phosphorylase DeoA (tdrpase) (pyrimidine phosphorylase) 0.0687 0.3924 1
Loa Loa (eye worm) oxidoreductase 0.0036 0.0086 0.0232
Echinococcus multilocularis thymidine phosphorylase 0.0687 0.3924 0.3922
Schistosoma mansoni ran 0.0022 0.0004 0.001
Plasmodium falciparum metacaspase 1 0.0027 0.0036 0.0791
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.0094 0.1008
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0087 0.0384 0.0847
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0153 0.0412
Leishmania major acetyl-CoA synthetase, putative 0.0036 0.0086 0.1393
Brugia malayi AMP-binding enzyme family protein 0.0036 0.0086 0.0923
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.0094 0.009
Onchocerca volvulus 0.0036 0.0086 0.0894
Schistosoma mansoni acetyl-CoA synthetase 0.0036 0.0086 0.0232
Plasmodium vivax hypothetical protein, conserved 0.0037 0.0094 0.2199
Loa Loa (eye worm) hypothetical protein 0.0122 0.0596 0.1603
Leishmania major 4-coumarate:coa ligase-like protein 0.0122 0.0596 1
Brugia malayi Bromodomain containing protein 0.0078 0.0332 0.3666
Trypanosoma cruzi metacaspase, putative 0.0027 0.0036 0.1996
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0036 0.0086 0.0076
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0036 0.0086 0.3578
Plasmodium falciparum metacaspase-like protein 0.0027 0.0036 0.0791
Brugia malayi beta-lactamase family protein 0.0037 0.0094 0.1008
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0036 0.0086 0.0076
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0122 0.0596 0.1328
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0004 0.001
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0153 0.0381
Schistosoma mansoni ran 0.0022 0.0004 0.001
Loa Loa (eye worm) hypothetical protein 0.0122 0.0596 0.1603
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0036 0.0086 0.0083
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0027 0.0036 0.1406
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0027 0.0036 0.1406
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0094 0.0252
Trypanosoma brucei metacaspase MCA3 0.0027 0.0036 0.1406
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0094 0.0252
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.0094 0.3908
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0094 0.5545
Mycobacterium ulcerans lipase LipD 0.0037 0.0094 0.002
Loa Loa (eye worm) hypothetical protein 0.0037 0.0094 0.0252
Trichomonas vaginalis esterase, putative 0.0037 0.0094 0.5545
Mycobacterium ulcerans anthranilate phosphoribosyltransferase 0.0194 0.1017 0.2426
Toxoplasma gondii propionate-CoA ligase 0.0036 0.0086 0.3578
Echinococcus granulosus importin subunit beta 1 0.0061 0.0234 0.0588
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0153 0.015
Mycobacterium tuberculosis Probable lipase LipD 0.0037 0.0094 0.0096
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0027 0.0036 0.0363
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0122 0.0596 0.1328
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0036 0.1996
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0036 0.0086 0.1393
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0027 0.0036 0.1996
Mycobacterium ulcerans acyl-CoA synthetase 0.0122 0.0596 0.1328
Mycobacterium ulcerans thymidine phosphorylase 0.0687 0.3924 1
Echinococcus granulosus caspase 3 0.0075 0.0318 0.0801
Loa Loa (eye worm) hypothetical protein 0.0061 0.0234 0.063
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0122 0.0596 0.5475
Trypanosoma brucei importin beta-1 subunit, putative 0.0061 0.0234 1
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0036 0.0086 0.0076
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0027 0.0036 0.1996
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0036 0.1996
Trypanosoma cruzi metacaspase, putative 0.0027 0.0036 0.1996
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0027 0.0036 0.1996
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0122 0.0596 0.1328
Leishmania major acetyl-CoA synthetase, putative 0.0036 0.0086 0.1393
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0036 0.0086 0.5076
Loa Loa (eye worm) hypothetical protein 0.0091 0.0414 0.1112
Schistosoma mansoni hypothetical protein 0.0037 0.0092 0.0247
Onchocerca volvulus 0.0036 0.0086 0.0894
Echinococcus granulosus caspase 2 0.0027 0.0036 0.0083
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0036 0.0086 0.021
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0036 0.1996
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0087 0.0384 0.0847
Loa Loa (eye worm) hypothetical protein 0.0027 0.0036 0.0097
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0062 0.0238 0.0598
Brugia malayi Calcitonin receptor-like protein seb-1 0.0054 0.0193 0.2114
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0037 0.0093 0.009
Mycobacterium tuberculosis Probable anthranilate phosphoribosyltransferase TrpD 0.0194 0.1017 0.2484
Echinococcus multilocularis geminin 0.0175 0.0907 0.0904
Loa Loa (eye worm) hypothetical protein 0.0091 0.0414 0.1112
Trypanosoma brucei metacaspase 0.0027 0.0036 0.1406
Schistosoma mansoni hypothetical protein 0.0652 0.3718 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0094 0.0252
Loa Loa (eye worm) hypothetical protein 0.0037 0.0094 0.0252
Entamoeba histolytica acyl-CoA synthetase, putative 0.0122 0.0596 0.768
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0087 0.0384 0.0847
Echinococcus multilocularis sentrin specific protease 7 0.0153 0.0775 0.0772
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0036 0.0086 0.5076
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0094 0.5545
Trypanosoma cruzi importin beta-1 subunit, putative 0.005 0.0166 1
Trypanosoma cruzi metacaspase 5, putative 0.0027 0.0036 0.1996
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0036 0.0086 0.0923
Loa Loa (eye worm) beta-lactamase 0.0037 0.0094 0.0252
Echinococcus multilocularis caspase 2 0.0027 0.0036 0.0032
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0037 0.0094 0.0096
Trichomonas vaginalis importin beta-1, putative 0.005 0.0166 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0108 0.0291
Loa Loa (eye worm) hypothetical protein 0.0037 0.0094 0.0252
Brugia malayi beta-lactamase family protein 0.0037 0.0094 0.1008
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0036 0.0086 0.0232
Echinococcus multilocularis caspase 8 0.0027 0.0036 0.0032
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0036 0.0086 0.3578
Onchocerca volvulus 0.0037 0.0094 0.103
Mycobacterium leprae Probable anthranilate phosphoribosyltransferase TrpD 0.0194 0.1017 1
Trichomonas vaginalis antibiotic synthetase, putative 0.0036 0.0086 0.5076
Trichomonas vaginalis Importin beta-1 subunit, putative 0.005 0.0166 1
Echinococcus multilocularis caspase 3 0.0075 0.0318 0.0314
Echinococcus multilocularis expressed conserved protein 0.0139 0.0696 0.0693
Brugia malayi AMP-binding enzyme family protein 0.0122 0.0596 0.6623
Brugia malayi RNA, U transporter 1 0.0174 0.0898 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0036 0.0086 0.0076
Brugia malayi AMP-binding enzyme family protein 0.0036 0.0086 0.0923
Brugia malayi Bromodomain containing protein 0.004 0.0108 0.1164
Loa Loa (eye worm) hypothetical protein 0.0091 0.0414 0.1112
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0027 0.0036 0.1996
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0094 0.5545
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0153 0.0775 1
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0022 0.0004 0.5
Trypanosoma cruzi metacaspase, putative 0.0027 0.0036 0.1996
Echinococcus granulosus caspase 8 0.0027 0.0036 0.0083
Brugia malayi beta-lactamase 0.0037 0.0094 0.1008
Mycobacterium leprae Probable lipase LipE 0.0037 0.0094 0.0082
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0087 0.0384 0.0847
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0023 0.0012 0.0008
Echinococcus granulosus snurportin 1 0.0652 0.3718 0.9474
Brugia malayi PHD-finger family protein 0.0026 0.0026 0.0251
Loa Loa (eye worm) hypothetical protein 0.0044 0.0134 0.0361
Loa Loa (eye worm) hypothetical protein 0.0036 0.0086 0.0232
Onchocerca volvulus 0.0037 0.0094 0.103
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0036 0.0086 0.0923
Schistosoma mansoni hypothetical protein 0.0175 0.0907 0.2441
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0094 0.5545
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0054 0.0193 0.2114
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.0094 0.0252
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0036 0.0086 0.0232
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0037 0.0094 0.0096
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0062 0.0238 0.0235
Schistosoma mansoni bromodomain containing protein 0.0065 0.026 0.0699
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0054 0.0193 0.0518
Trichomonas vaginalis Importin beta-1 subunit, putative 0.005 0.0166 1
Echinococcus granulosus thymidine phosphorylase 0.0687 0.3924 1
Schistosoma mansoni hypothetical protein 0.0175 0.0907 0.2441
Plasmodium falciparum acyl-CoA synthetase 0.0091 0.0414 1
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0122 0.0596 0.5475
Plasmodium vivax importin-beta 2, putative 0.0061 0.0234 0.5627
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0036 0.1996
Echinococcus granulosus expressed conserved protein 0.0139 0.0696 0.1767
Brugia malayi Importin beta-1 subunit 0.0061 0.0234 0.2579
Onchocerca volvulus 0.0036 0.0086 0.0894
Mycobacterium ulcerans acyl-CoA synthetase 0.0122 0.0596 0.1328
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0037 0.0094 0.0096
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0036 0.0086 0.0076
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0652 0.3718 1
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0027 0.0036 0.1996
Trypanosoma brucei Metacaspase-4 0.0027 0.0036 0.1406
Entamoeba histolytica acyl-CoA synthetase, putative 0.0122 0.0596 0.768
Brugia malayi Cell death protein 3 precursor 0.0027 0.0036 0.0363
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0036 0.0086 0.0076
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0036 0.0086 0.3578
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0153 0.015
Schistosoma mansoni family C48 unassigned peptidase (C48 family) 0.0153 0.0775 0.2084
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0238 0.1277 0.3155
Leishmania major 4-coumarate:coa ligase-like protein 0.0122 0.0596 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0036 0.0097
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0153 0.0412
Brugia malayi AMP-binding enzyme family protein 0.0122 0.0596 0.6623
Brugia malayi AMP-binding enzyme family protein 0.0036 0.0086 0.0923
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0027 0.0036 0.1996
Schistosoma mansoni importin beta-1 0.0061 0.0234 0.063
Mycobacterium tuberculosis Conserved protein 0.0037 0.0094 0.0096
Echinococcus multilocularis caspase 0.0103 0.0479 0.0476
Plasmodium vivax acyl-CoA synthetase, putative 0.0091 0.0414 1
Mycobacterium tuberculosis Conserved protein 0.0037 0.0094 0.0096
Mycobacterium ulcerans hypothetical protein 0.0122 0.0596 0.1328
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0023 0.0012 0.0031
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0027 0.0036 0.1406
Loa Loa (eye worm) hypothetical protein 0.0054 0.0193 0.0518
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0036 0.0086 0.2013
Onchocerca volvulus 0.0122 0.0596 1
Brugia malayi AMP-binding enzyme family protein 0.0122 0.0596 0.6623
Mycobacterium ulcerans esterase/lipase LipP 0.0037 0.0094 0.002
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0036 0.0086 0.0076
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0027 0.0036 0.1996
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0036 0.0086 0.0076
Echinococcus multilocularis snurportin 1 0.0652 0.3718 0.3716
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0091 0.0414 0.0853
Leishmania major 4-coumarate:coa ligase-like protein 0.0122 0.0596 1
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0036 0.0086 0.0076
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.0094 0.023
Loa Loa (eye worm) hypothetical protein 0.0073 0.0305 0.0821
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0103 0.0479 0.0476
Mycobacterium tuberculosis Conserved protein 0.0037 0.0094 0.0096
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0036 0.0086 0.0076

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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