Detailed information for compound 628767

Basic information

Technical information
  • TDR Targets ID: 628767
  • Name: ethyl 2-(4-chlorophenyl)-7-(furan-2-carbonyla mino)-1-oxothieno[4,3-d]pyridazine-4-carboxyl ate
  • MW: 443.86 | Formula: C20H14ClN3O5S
  • H donors: 1 H acceptors: 3 LogP: 4.51 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)c1nn(c2ccc(cc2)Cl)c(=O)c2c1csc2NC(=O)c1ccco1
  • InChi: 1S/C20H14ClN3O5S/c1-2-28-20(27)16-13-10-30-18(22-17(25)14-4-3-9-29-14)15(13)19(26)24(23-16)12-7-5-11(21)6-8-12/h3-10H,2H2,1H3,(H,22,25)
  • InChiKey: YJSXATTVYRKCLC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • ethyl 2-(4-chlorophenyl)-7-(furan-2-carbonylamino)-1-oxo-thieno[4,3-d]pyridazine-4-carboxylate
  • 2-(4-chlorophenyl)-7-[(2-furyl-oxomethyl)amino]-1-oxo-4-thieno[4,3-d]pyridazinecarboxylic acid ethyl ester
  • 2-(4-chlorophenyl)-7-(furan-2-carbonylamino)-1-keto-thieno[4,3-d]pyridazine-4-carboxylic acid ethyl ester
  • ethyl 2-(4-chlorophenyl)-7-(furan-2-ylcarbonylamino)-1-oxo-thieno[4,3-d]pyridazine-4-carboxylate

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0007 0.0048 0.0531
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0251 0.0224
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0395 0.5767
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0007 0.0048 0.0041
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0395 0.5767
Loa Loa (eye worm) calpain family protein 1 0.0044 0.0815 0.1325
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0282 0.0455
Echinococcus granulosus calpain A 0.0066 0.1267 0.1468
Trypanosoma cruzi kinesin, putative 0.0019 0.0289 0.195
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0512 0.0585
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0066 0.1267 0.1468
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0007 0.0048 0.0322
Loa Loa (eye worm) hypothetical protein 0.0024 0.0395 0.0632
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.0271 0.0436
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0077 0.1484 0.146
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0007 0.0048 0.0058
Loa Loa (eye worm) hypothetical protein 0.0024 0.0395 0.0632
Loa Loa (eye worm) hypothetical protein 0.0077 0.1484 0.2431
Loa Loa (eye worm) calpain 0.0019 0.0289 0.0457
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.0819 0.1988
Mycobacterium tuberculosis Conserved protein 0.0077 0.1484 0.146
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0038 0.0676 0.4555
Brugia malayi Pre-SET motif family protein 0.003 0.0512 0.1232
Trichomonas vaginalis antibiotic synthetase, putative 0.0007 0.0048 0.0076
Loa Loa (eye worm) histone methyltransferase 0.001 0.0113 0.0166
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0819 0.0944
Leishmania major hypothetical protein, conserved 0.0005 0.0013 0.0085
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0819 0.0944
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0019 0.0289 0.1881
Trypanosoma brucei calpain-like protein, putative 0.0019 0.0289 0.1881
Loa Loa (eye worm) hypothetical protein 0.0077 0.1484 0.2431
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0019 0.0289 0.195
Loa Loa (eye worm) hypothetical protein 0.0063 0.12 0.1962
Echinococcus granulosus calpain 5 0.0019 0.0289 0.0324
Trypanosoma brucei kinesin, putative 0.0019 0.0289 0.1881
Brugia malayi Importin beta-1 subunit 0.0028 0.0481 0.1154
Plasmodium vivax SET domain protein, putative 0.003 0.0512 0.0843
Schistosoma mansoni calpain-7 (C02 family) 0.0022 0.0352 0.0397
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0066 0.1267 0.1468
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0395 0.5767
Schistosoma mansoni importin beta-1 0.0028 0.0481 0.0548
Loa Loa (eye worm) hypothetical protein 0.0018 0.0271 0.0427
Loa Loa (eye worm) hypothetical protein 0.0018 0.0271 0.0427
Schistosoma mansoni cpg binding protein 0.0031 0.0546 0.0624
Mycobacterium leprae PROBABLE NICOTINATE-NUCLEOTIDE ADENYLYLTRANSFERASE NADD (DEAMIDO-NAD(+) PYROPHOSPHORYLASE) (DEAMIDO-NAD(+) DIPHOSPHORYLASE) (NIC 0.0293 0.594 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0372 0.0775
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0038 0.0676 0.4555
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0512 0.0585
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0007 0.0048 0.002
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0395 0.0589
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0077 0.1484 0.3627
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0676 0.1432
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0038 0.0676 0.0776
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0007 0.0048 0.002
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0041 0.0062
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0676 0.1432
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0077 0.1484 0.1722
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0395 0.2663
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0395 0.0589
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0041 0.0062
Schistosoma mansoni cpg binding protein 0.0031 0.0546 0.0624
Plasmodium vivax nicotinate-nucleotide adenylyltransferase, putative 0.0293 0.594 1
Leishmania major importin beta-1 subunit, putative 0.0023 0.0372 0.2504
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0041 0.0062
Loa Loa (eye worm) hypothetical protein 0.0044 0.0815 0.1325
Loa Loa (eye worm) hypothetical protein 0.0077 0.1484 0.2431
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0007 0.0048 0.002
Echinococcus multilocularis calpain family protein 1, d 0.0044 0.0815 0.0939
Trichomonas vaginalis set domain proteins, putative 0.023 0.4643 1
Trichomonas vaginalis D-aminoacylase, putative 0.0077 0.1484 0.3177
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0038 0.0676 0.1635
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0007 0.0048 0.0322
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0018 0.0271 0.5
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0007 0.0048 0.0058
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0077 0.1484 0.2431
Plasmodium falciparum nicotinamide/nicotinic acid mononucleotide adenylyltransferase 0.0293 0.594 1
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0019 0.0289 0.195
Onchocerca volvulus 0.0024 0.0395 0.0756
Plasmodium vivax acetyl-CoA synthetase, putative 0.0007 0.0048 0.0059
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0372 0.2504
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0038 0.0676 0.0776
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0007 0.0048 0.0087
Mycobacterium tuberculosis Conserved protein 0.0077 0.1484 0.146
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.0048 0.002
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0395 0.0589
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0395 0.0943
Trypanosoma brucei antigen, putative 0.0019 0.0289 0.1881
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0282 0.0582
Onchocerca volvulus 0.0077 0.1484 0.3125
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0819 0.0944
Entamoeba histolytica hypothetical protein 0.0023 0.0372 0.5411
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0282 0.0582
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.1188 0.1935
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0062 0.1188 0.8006
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0395 0.0589
Mycobacterium ulcerans esterase/lipase LipP 0.0077 0.1484 0.2437
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0038 0.0676 0.0776
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0481 0.3181
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0019 0.0289 0.195
Loa Loa (eye worm) hypothetical protein 0.0024 0.0395 0.0632
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0041 0.0062
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.0048 0.002
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0007 0.0048 0.002
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0007 0.0048 0.0041
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0019 0.0289 0.195
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0008 0.0076 0.0075
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0038 0.0676 1
Toxoplasma gondii histone lysine methyltransferase SET1 0.0057 0.1076 0.7231
Echinococcus granulosus mixed lineage leukemia protein mll 0.0008 0.0076 0.0075
Brugia malayi beta-lactamase family protein 0.0077 0.1484 0.3627
Schistosoma mansoni calpain-7 (C02 family) 0.0022 0.0352 0.0397
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0041 0.0062
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0395 0.0589
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0395 0.0589
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0019 0.0289 0.195
Mycobacterium ulcerans beta-lactamase 0.0077 0.1484 0.2437
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0395 0.0943
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0019 0.0289 0.195
Entamoeba histolytica protein kinase, putative 0.0019 0.0289 0.4173
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0512 0.0585
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0041 0.0062
Mycobacterium ulcerans lipase LipD 0.0077 0.1484 0.2437
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0041 0.0062
Echinococcus granulosus geminin 0.0185 0.3715 0.4333
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0008 0.0076 0.0075
Schistosoma mansoni hypothetical protein 0.0185 0.3715 0.4333
Treponema pallidum hypothetical protein 0.0293 0.594 1
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0282 0.1832
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0019 0.0289 0.195
Onchocerca volvulus 0.003 0.0512 0.1011
Loa Loa (eye worm) hypothetical protein 0.0077 0.1484 0.2431
Leishmania major hypothetical protein, conserved 0.0077 0.1484 1
Mycobacterium leprae Probable lipase LipE 0.0077 0.1484 0.2437
Trichomonas vaginalis helicase, putative 0.0007 0.0041 0.0062
Schistosoma mansoni calpain C (C02 family) 0.0019 0.0289 0.0324
Leishmania major acetyl-CoA synthetase, putative 0.0007 0.0048 0.0322
Brugia malayi RNA, U transporter 1 0.008 0.1545 0.3777
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0113 0.0118
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0019 0.0289 0.195
Schistosoma mansoni hypothetical protein 0.0421 0.8556 1
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0477 0.0544
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0282 0.1901
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0007 0.0048 0.0087
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0007 0.0048 0.002
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0395 0.0943
Echinococcus granulosus importin subunit beta 1 0.0028 0.0481 0.0548
Echinococcus granulosus ubiquitin specific protease 41 0.0038 0.0676 0.0776
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0512 0.0585
Brugia malayi calpain 7 0.0019 0.0289 0.0682
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0041 0.0062
Mycobacterium tuberculosis Probable lipase LipD 0.0077 0.1484 0.146
Echinococcus granulosus cpg binding protein 0.0031 0.0546 0.0624
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0019 0.0289 0.195
Schistosoma mansoni calpain (C02 family) 0.0019 0.0289 0.0324
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0481 0.0548
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0038 0.0676 0.0776
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0282 0.0445
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0064 0.1214 0.1406
Echinococcus multilocularis beta LACTamase domain containing family member 0.0077 0.1484 0.1722
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0282 0.0255
Loa Loa (eye worm) hypothetical protein 0.0038 0.0676 0.1096
Leishmania major acetyl-CoA synthetase, putative 0.0007 0.0048 0.0322
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0063 0.12 0.139
Echinococcus multilocularis ubiquitin specific protease 41 0.0038 0.0676 0.0776
Echinococcus multilocularis calpain 7 (C02 family) 0.0019 0.0289 0.0324
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0038 0.0676 0.0776
Schistosoma mansoni Mername-AA248 (C02 family) 0.0019 0.0289 0.0324
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0066 0.1267 0.1468
Brugia malayi AMP-binding enzyme family protein 0.0007 0.0048 0.0087
Brugia malayi beta-lactamase 0.0077 0.1484 0.3627
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0007 0.0048 0.002
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0007 0.0048 0.0322
Toxoplasma gondii ABC1 family protein 0.0077 0.1484 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0041 0.0062
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0062 0.1188 0.1163
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0372 0.0775
Onchocerca volvulus 0.003 0.0511 0.1008
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0282 0.1901
Echinococcus multilocularis cpg binding protein 0.0031 0.0546 0.0624
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0077 0.1484 0.146
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0007 0.0048 0.0239
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0511 0.0823
Echinococcus multilocularis calpain 0.0019 0.0289 0.0324
Brugia malayi CXXC zinc finger family protein 0.003 0.0511 0.1229
Onchocerca volvulus 0.023 0.4643 1
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0007 0.0048 0.002
Echinococcus granulosus calpain A 0.0019 0.0289 0.0324
Mycobacterium ulcerans hypothetical protein 0.0077 0.1484 0.2437
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0395 0.0368
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0019 0.0289 0.195
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0299 0.6065 1
Leishmania major kinesin, putative 0.0019 0.0289 0.195
Trypanosoma cruzi kinesin, putative 0.0019 0.0289 0.195
Brugia malayi Pre-SET motif family protein 0.0202 0.4069 1
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0282 0.1901
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0041 0.0062
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0077 0.1484 0.146
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0066 0.1267 0.1468
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0819 0.0944
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0251 0.0224
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0512 0.0585
Loa Loa (eye worm) hypothetical protein 0.0077 0.1484 0.2431
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0018 0.0271 0.0378
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.0048 0.002
Trichomonas vaginalis penicillin-binding protein, putative 0.0077 0.1484 0.3177
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0251 0.0224
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0481 0.3181
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0062 0.1188 0.1376
Onchocerca volvulus 0.0044 0.0815 0.1669
Brugia malayi calpain family protein 1 0.0063 0.12 0.2928
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0041 0.0062
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0038 0.0676 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0819 0.0944
Brugia malayi AMP-binding enzyme family protein 0.0007 0.0048 0.0087
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0019 0.0289 0.1881
Trypanosoma cruzi hypothetical protein, conserved 0.0077 0.1484 1
Loa Loa (eye worm) hypothetical protein 0.0063 0.12 0.1962
Mycobacterium tuberculosis Probable lipase LipE 0.0077 0.1484 0.146
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.1188 0.1376
Entamoeba histolytica calpain large subunit domain III containing protein 0.0019 0.0289 0.4173
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0512 0.3397
Loa Loa (eye worm) hypothetical protein 0.0028 0.0481 0.0773
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.1188 0.1376
Loa Loa (eye worm) hypothetical protein 0.0044 0.0815 0.1325
Trypanosoma brucei calpain-like protein, putative 0.0019 0.0289 0.1881
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0038 0.0676 0.0776
Plasmodium vivax calpain, putative 0.0019 0.0289 0.0467
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0007 0.0048 0.0239
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0062 0.1188 0.1376
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.0282 0.0398
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.1188 0.1935
Loa Loa (eye worm) hypothetical protein 0.0007 0.0048 0.0058
Brugia malayi calpain family protein 1 0.0063 0.12 0.2928
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0041 0.0062
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0395 0.0368
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0282 0.0315
Loa Loa (eye worm) hypothetical protein 0.0018 0.0271 0.0427
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0019 0.0289 0.195
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0512 0.0585
Plasmodium vivax importin-beta 2, putative 0.0028 0.0481 0.079
Echinococcus multilocularis calpain A 0.0066 0.1267 0.1468
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0041 0.0062
Echinococcus multilocularis calpain 5 0.0019 0.0289 0.0324
Toxoplasma gondii aldehyde dehydrogenase 0.0062 0.1188 0.7989
Mycobacterium leprae conserved hypothetical protein 0.0077 0.1484 0.2437
Echinococcus multilocularis snurportin 1 0.0299 0.6065 0.7084
Brugia malayi beta-lactamase family protein 0.0077 0.1484 0.3627
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0041 0.0062
Echinococcus granulosus beta LACTamase domain containing family member 0.0077 0.1484 0.1722
Trichomonas vaginalis D-aminoacylase, putative 0.0077 0.1484 0.3177
Trichomonas vaginalis penicillin-binding protein, putative 0.0077 0.1484 0.3177
Echinococcus multilocularis dnaJ subfamily B 0.0421 0.8556 1
Trichomonas vaginalis esterase, putative 0.0077 0.1484 0.3177
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0395 0.0589
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0008 0.0076 0.0075
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0041 0.0062
Loa Loa (eye worm) calpain 5 0.0019 0.0289 0.0457
Schistosoma mansoni hypothetical protein 0.0299 0.6065 0.7084
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0113 0.0118
Onchocerca volvulus 0.0077 0.1484 0.3125
Echinococcus granulosus dnaJ subfamily B 0.0421 0.8556 1
Mycobacterium tuberculosis Probable nicotinate-nucleotide adenylyltransferase NadD (deamido-NAD(+) pyrophosphorylase) (deamido-NAD(+) diphosphorylase) (nic 0.0293 0.594 0.5929
Schistosoma mansoni ap endonuclease 0.0018 0.0282 0.0316
Mycobacterium ulcerans hypothetical protein 0.0024 0.0395 0.0589
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0202 0.4069 0.6702
Mycobacterium ulcerans bifunctional nicotinate-nucleotide adenylyltransferase NadD/hypothetical protein 0.0293 0.594 1
Toxoplasma gondii exonuclease III APE 0.0018 0.0282 0.1832
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0819 0.0944
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.0271 0.0436
Schistosoma mansoni cpg binding protein 0.003 0.0511 0.0583
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.0048 0.002
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0007 0.0048 0.0239
Brugia malayi calpain 5 0.0019 0.0289 0.0682
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.0282 0.4063
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.0019 0.0289 0.195
Trypanosoma brucei calpain-like protein, putative 0.0019 0.0289 0.1881
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0271 0.0244
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0007 0.0048 0.0322
Schistosoma mansoni acetyl-CoA synthetase 0.0007 0.0048 0.0041
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0007 0.0048 0.0322
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0019 0.0289 0.195
Brugia malayi AMP-binding enzyme family protein 0.0007 0.0048 0.0087
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0038 0.0676 0.4508
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0395 0.2663
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0038 0.0676 0.4555
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0008 0.0076 0.0075
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0007 0.0048 0.0059
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0251 0.0224
Loa Loa (eye worm) calpain family protein 1 0.0063 0.12 0.1962
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0282 0.0315
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.1188 0.1935
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0481 0.3181
Loa Loa (eye worm) oxidoreductase 0.0007 0.0048 0.0058
Loa Loa (eye worm) hypothetical protein 0.0018 0.0271 0.0427
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0395 0.0589
Loa Loa (eye worm) beta-lactamase 0.0077 0.1484 0.2431
Schistosoma mansoni ap endonuclease 0.0018 0.0282 0.0316
Plasmodium falciparum importin beta, putative 0.0028 0.0481 0.079
Echinococcus granulosus calpain 7 C02 family 0.0019 0.0289 0.0324
Echinococcus multilocularis geminin 0.0185 0.3715 0.4333
Trypanosoma cruzi hypothetical protein, conserved 0.0077 0.1484 1
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0111 0.0242
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0395 0.0589
Mycobacterium tuberculosis Probable hydrolase 0.0077 0.1484 0.146
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0512 0.0585
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0077 0.1484 0.1722
Schistosoma mansoni hypothetical protein 0.0185 0.3715 0.4333
Echinococcus granulosus calpain 0.0019 0.0289 0.0324
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0077 0.1484 0.2437
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0041 0.0062
Plasmodium vivax hypothetical protein, conserved 0.0077 0.1484 0.2482
Mycobacterium tuberculosis Conserved protein 0.0077 0.1484 0.146
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0007 0.0048 0.0239
Loa Loa (eye worm) hypothetical protein 0.003 0.0512 0.0826
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0282 0.0455
Echinococcus granulosus snurportin 1 0.0299 0.6065 0.7084
Loa Loa (eye worm) hypothetical protein 0.0018 0.0271 0.0427
Toxoplasma gondii propionate-CoA ligase 0.0007 0.0048 0.0239
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0041 0.0062
Trypanosoma brucei hypothetical protein, conserved 0.0077 0.1484 1
Onchocerca volvulus 0.0077 0.1484 0.3125
Mycobacterium tuberculosis Probable esterase LipL 0.0077 0.1484 0.146
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0676 0.1432
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0282 0.5
Trypanosoma brucei calpain-like protein, putative 0.0019 0.0289 0.1881
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0282 0.0664
Trichomonas vaginalis D-aminoacylase, putative 0.0077 0.1484 0.3177
Brugia malayi AMP-binding enzyme family protein 0.0007 0.0048 0.0087
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0819 0.0944
Loa Loa (eye worm) hypothetical protein 0.0007 0.0048 0.0058
Loa Loa (eye worm) hypothetical protein 0.0077 0.1484 0.2431
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0395 0.2663
Echinococcus multilocularis hypothetical protein 0.0019 0.0289 0.0324
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0372 0.0775
Trichomonas vaginalis antibiotic synthetase, putative 0.0007 0.0048 0.0076
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.0819 0.1332

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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