TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 740.974 | Formula: C34H56N6O8S2
H donors: 4 H acceptors: 4 LogP: 4.58 Rotable bonds: 31
Rule of 5 violations (Lipinski): 2
SMILES: COc1cc(CNCCCCCCNCCSSCCNCCCCCCNCc2cc(OC)c(cc2[N+](=O)[O-])OC)c(cc1OC)[N+](=O)[O-]
InChi: 1S/C34H56N6O8S2/c1-45-31-21-27(29(39(41)42)23-33(31)47-3)25-37-15-11-7-5-9-13-35-17-19-49-50-20-18-36-14-10-6-8-12-16-38-26-28-22-32(46-2)34(48-4)24-30(28)40(43)44/h21-24,35-38H,5-20,25-26H2,1-4H3
InChiKey: MUCCOXOWANDBKD-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0012	0.0015	0.0036
Trypanosoma brucei	hypothetical protein, conserved	0.0072	0.065	0.0835
Brugia malayi	Ser/Thr protein phosphatase family protein	0.0206	0.2058	0.4833
Leishmania major	serine/threonine-protein phosphatase PP1, putative	0.0046	0.0373	0.0479
Trichomonas vaginalis	bsu-protein phosphatase, putative	0.005	0.0418	0.2032
Loa Loa (eye worm)	hypothetical protein	0.0281	0.2838	0.6663
Schistosoma mansoni	protein phosphatase type 1	0.0046	0.0373	0.0876
Trichomonas vaginalis	protein phosphatase 2A, caeel, putative	0.0011	0.0001	0.0005
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0044	0.035	0.1699
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0012	0.0015	0.0036
Trichomonas vaginalis	serine/threonine protein phosphatase, putative	0.0046	0.0373	0.1812
Echinococcus granulosus	serine:threonine protein phosphatase PP1 beta	0.005	0.0418	0.0982
Echinococcus multilocularis	survival motor neuron protein 1	0.0281	0.2838	0.2838
Brugia malayi	nuclear receptor NHR-88	0.0012	0.0015	0.0036
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0044	0.035	0.0449
Leishmania major	hypothetical protein, conserved	0.0072	0.065	0.0835
Brugia malayi	Serine/threonine protein phosphatase PP1-beta catalytic subunit	0.005	0.0418	0.0982
Brugia malayi	Serine/threonine protein phosphatase PP1 isozyme 1, putative	0.0046	0.0373	0.0876
Brugia malayi	Steroid receptor seven-up type 2	0.0012	0.0015	0.0036
Plasmodium vivax	serine/threonine protein phosphatase PP1, putative	0.005	0.0418	1
Trichomonas vaginalis	protein phosphatase, caeel, putative	0.0206	0.2058	1
Echinococcus granulosus	protein phosphatase pp2a regulatory subunit b	0.0072	0.065	0.1526
Schistosoma mansoni	RAR-like nuclear receptor	0.0012	0.0015	0.0036
Schistosoma mansoni	inositol monophosphatase	0.0044	0.035	0.0821
Entamoeba histolytica	protein phosphatase regulatory subunit, putative	0.0072	0.065	1
Trichomonas vaginalis	phosphoserine/threonine phosphatase, putative	0.0206	0.2058	1
Schistosoma mansoni	nuclear hormone receptor	0.0012	0.0015	0.0036
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0012	0.0015	0.0036
Loa Loa (eye worm)	serine/threonine protein phosphatase PP1-alpha catalytic subunit	0.0046	0.0373	0.0876
Leishmania major	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0044	0.035	0.0449
Schistosoma mansoni	ap endonuclease	0.0022	0.0124	0.029
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0012	0.0015	0.0015
Schistosoma mansoni	protein kinase	0.0142	0.1382	0.3246
Echinococcus granulosus	protein phosphatase 1 catalytic subunit	0.0011	0.0001	0.0002
Brugia malayi	Dual specificity mitogen-activated protein kinase kinase 7. -TRUNCATED-	0.0142	0.1382	0.3246
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0012	0.0015	0.0036
Brugia malayi	hypothetical protein	0.0281	0.2838	0.6663
Trichomonas vaginalis	protein phosphatase-7, putative	0.0206	0.2058	1
Leishmania major	protein phosphatase 2A regulatory subunit, putative	0.0072	0.065	0.0835
Trichomonas vaginalis	protein phosphatase 2A, caeel, putative	0.0206	0.2058	1
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0012	0.0015	0.0036
Trichomonas vaginalis	bsu-protein phosphatase, putative	0.0206	0.2058	1
Echinococcus granulosus	survival motor neuron protein 1	0.0281	0.2838	0.6663
Trichomonas vaginalis	serine/threonine protein phosphatase, putative	0.0046	0.0373	0.1812
Brugia malayi	Inositol-1	0.0044	0.035	0.0821
Trichomonas vaginalis	protein phosphatase-1, putative	0.0206	0.2058	1
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0012	0.0015	0.0036
Trichomonas vaginalis	bsu-protein phosphatase, putative	0.0046	0.0373	0.1812
Trichomonas vaginalis	protein phosphatase, caeel, putative	0.0206	0.2058	1
Brugia malayi	exodeoxyribonuclease III family protein	0.0022	0.0124	0.029
Trichomonas vaginalis	protein phosphatase, caeel, putative	0.0206	0.2058	1
Loa Loa (eye worm)	serine/threonine protein phosphatase PP1-alpha catalytic subunit	0.0046	0.0373	0.0876
Loa Loa (eye worm)	serine/threonine-protein phosphatase PP1-beta	0.0011	0.0001	0.0002
Trypanosoma cruzi	protein phosphatase 2A regulatory subunit, putative	0.0072	0.065	0.0835
Schistosoma mansoni	protein phosphatase pp2a regulatory subunit B	0.0072	0.065	0.1526
Trichomonas vaginalis	protein phsophatase-2A, putative	0.0206	0.2058	1
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0373	0.0876
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0012	0.0015	0.0036
Trichomonas vaginalis	protein phosphatase-5, putative	0.0046	0.0373	0.1812
Trichomonas vaginalis	protein phsophatase-2A, putative	0.0206	0.2058	1
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0012	0.0015	0.0036
Trypanosoma cruzi	hypothetical protein, conserved	0.0072	0.065	0.0835
Loa Loa (eye worm)	hypothetical protein	0.002	0.0099	0.0232
Schistosoma mansoni	protein phosphatase-1	0.005	0.0418	0.0982
Toxoplasma gondii	serine/threonine phosophatase PP1	0.005	0.0418	1
Trichomonas vaginalis	serine/threonine protein phosphatase, putative	0.0206	0.2058	1
Toxoplasma gondii	inositol(myo)-1(or 4)-monophosphatase 2, putative	0.0044	0.035	0.7854
Brugia malayi	Serine/threonine protein phosphatase PP1-gamma catalytic subunit	0.0046	0.0373	0.0876
Echinococcus granulosus	serine:threonine protein phosphatase PP1 gamma	0.005	0.0418	0.0982
Trichomonas vaginalis	protein phosphatase pp2a regulatory subunit B, putative	0.0072	0.065	0.3157
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0015	0.0036
Brugia malayi	delta isoform of regulatory subunit B56, protein phosphatase 2A	0.002	0.0099	0.0232
Brugia malayi	serine/threonine protein phosphatase 2A	0.0072	0.065	0.1526
Schistosoma mansoni	ap endonuclease	0.0022	0.0124	0.029
Mycobacterium tuberculosis	Inositol-1-monophosphatase SuhB	0.0039	0.0301	1
Trichomonas vaginalis	protein phosphatase-7, caeel, putative	0.0206	0.2058	1
Echinococcus multilocularis	protein phosphatase 1 catalytic subunit	0.005	0.0418	0.0418
Schistosoma mansoni	protein phosphatase 2a regulatory subunit	0.002	0.0099	0.0232
Schistosoma mansoni	protein phosphatase 2a regulatory subunit	0.002	0.0099	0.0232
Loa Loa (eye worm)	hypothetical protein	0.02	0.1992	0.4677
Schistosoma mansoni	retinoic acid receptor RXR	0.0012	0.0015	0.0036
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0012	0.0015	0.0036
Entamoeba histolytica	serine/threonine protein phosphatase PP1, putative	0.0046	0.0373	0.5739
Trichomonas vaginalis	protein phosphatase, caeel, putative	0.0046	0.0373	0.1812
Schistosoma mansoni	protein phosphatase type 1	0.005	0.0418	0.0982
Trypanosoma cruzi	serine/threonine protein phosphatase catalytic subunit, putative	0.005	0.0418	0.0537
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0022	0.0124	0.0159
Echinococcus multilocularis	Serine threonine specific protein phosphatase bis(5 nucleosyl) tetraphosphatase	0.0011	0.0001	0.0001
Trichomonas vaginalis	protein phosphatase, caeel, putative	0.0206	0.2058	1
Brugia malayi	Ser/Thr protein phosphatase family protein	0.0206	0.2058	0.4833
Onchocerca volvulus		0.0206	0.2058	0.2666
Trichomonas vaginalis	protein phosphatase-1, putative	0.0206	0.2058	1
Echinococcus granulosus	FTZ F1 alpha	0.0012	0.0015	0.0036
Trichomonas vaginalis	protein phosphatase 2A, regulatory subunit, putative	0.002	0.0099	0.0479
Trichomonas vaginalis	protein phsophatase-2A, putative	0.0206	0.2058	1
Echinococcus multilocularis	Serine threonine specific protein phosphatase bis(5 nucleosyl) tetraphosphatase	0.0011	0.0001	0.0001
Echinococcus granulosus	serine:threonine protein phosphatase 2A 56 kDa	0.002	0.0099	0.0232
Schistosoma mansoni	thyroid hormone receptor	0.0012	0.0015	0.0036
Brugia malayi	putative serine/threonine phosphatase	0.0046	0.0373	0.0876
Leishmania major	serine/threonine-protein phosphatase PP1, putative	0.0751	0.7787	1
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0012	0.0015	0.0015
Loa Loa (eye worm)	hypothetical protein	0.02	0.1992	0.4677
Giardia lamblia	Protein phosphatase PP2A regulatory subunit B	0.0072	0.065	1
Echinococcus granulosus	serine:threonine protein phosphatase 2A 56 kDa	0.002	0.0099	0.0232
Trichomonas vaginalis	protein phosphatase PP2A regulatory subunit B, putative	0.0072	0.065	0.3157
Trichomonas vaginalis	protein phosphatase-7, putative	0.0206	0.2058	1
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0012	0.0015	0.0036
Echinococcus multilocularis	inositol monophosphatase 1	0.0044	0.035	0.035
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0015	0.0036
Trichomonas vaginalis	protein phosphatase-1, putative	0.0206	0.2058	1
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0022	0.0124	0.029
Trichomonas vaginalis	protein phosphatase 2A, regulatory subunit, putative	0.002	0.0099	0.0479
Echinococcus granulosus	protein phosphatase 1, catalytic subunit, beta isozyme	0.005	0.0418	0.0982
Echinococcus multilocularis	serine:threonine protein phosphatase PP1 gamma	0.005	0.0418	0.0418
Schistosoma mansoni	protein phosphatase-1	0.0046	0.0373	0.0876
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0012	0.0015	0.0036
Trypanosoma cruzi	serine/threonine-protein phosphatase PP1 alpha	0.0206	0.2058	0.2644
Trichomonas vaginalis	protein phsophatase-2A, putative	0.0206	0.2058	1
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0015	0.0036
Onchocerca volvulus		0.0057	0.0491	0.0635
Echinococcus granulosus	ecdysone induced protein 78C	0.0012	0.0015	0.0036
Trichomonas vaginalis	protein phosphatase-1, putative	0.0046	0.0373	0.1812
Trypanosoma brucei	protein phosphatase 2A regulatory subunit, putative	0.0072	0.065	0.0835
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0012	0.0015	0.0036
Entamoeba histolytica	serine/threonine protein phosphatase PP1-2, putative	0.0011	0.0001	0.0016
Toxoplasma gondii	exonuclease III APE	0.0022	0.0124	0.0784
Leishmania major	serine/threonine-protein phosphatase PP1, putative	0.0046	0.0373	0.0479
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0012	0.0015	0.0036
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0012	0.0015	0.0036
Echinococcus multilocularis	protein phosphatase 2a regulatory subunit	0.002	0.0099	0.0099
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0012	0.0015	0.0036
Schistosoma mansoni	survival motor neuron protein	0.0057	0.0491	0.1152
Trypanosoma cruzi	protein phosphatase 2A regulatory subunit, putative	0.0072	0.065	0.0835
Trichomonas vaginalis	protein phosphatase, caeel, putative	0.0206	0.2058	1
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0044	0.035	0.0449
Brugia malayi	ecdysteroid receptor	0.0012	0.0015	0.0036
Loa Loa (eye worm)	hypothetical protein	0.0145	0.1417	0.3326
Schistosoma mansoni	protein phosphatase-1	0.0046	0.0373	0.0876
Trypanosoma cruzi	serine/threonine-protein phosphatase PP1, putative	0.0164	0.1615	0.2074
Trichomonas vaginalis	bsu-protein phosphatase, putative	0.0206	0.2058	1
Trichomonas vaginalis	protein phosphatase-1, putative	0.0206	0.2058	1
Echinococcus granulosus	serine:threonine protein phosphatase PP1 gamma	0.005	0.0418	0.0982
Schistosoma mansoni	coup transcription factor	0.0012	0.0015	0.0036
Trypanosoma brucei	serine threonine-protein phosphatase PP1, putative	0.0246	0.2476	0.318
Trypanosoma cruzi	serine/threonine-protein phosphatase PP1, putative	0.0246	0.2476	0.318
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0416	0.4259	1
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0012	0.0015	0.0015
Loa Loa (eye worm)	hypothetical protein	0.005	0.0418	0.0982
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0022	0.0124	0.029
Echinococcus granulosus	dual specificity mitogen activated protein	0.0142	0.1382	0.3246
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0015	0.0036
Schistosoma mansoni	inositol monophosphatase	0.0044	0.035	0.0821
Trichomonas vaginalis	protein phosphatase, caeel, putative	0.0206	0.2058	1
Trichomonas vaginalis	protein phosphatase-1, putative	0.0206	0.2058	1
Echinococcus multilocularis	serine:threonine protein phosphatase 2A 56 kDa	0.002	0.0099	0.0099
Trypanosoma brucei	serine threonine-protein phosphatase PP1, putative	0.0046	0.0373	0.0479
Loa Loa (eye worm)	serine/threonine protein phosphatase PP1-gamma catalytic subunit	0.0046	0.0373	0.0876
Trypanosoma brucei	inositol-1(or 4)-monophosphatase 1, putative	0.0044	0.035	0.0449
Mycobacterium leprae	possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ).	0.0039	0.0301	0.5
Trichomonas vaginalis	ap endonuclease, putative	0.0022	0.0124	0.0601
Trypanosoma brucei	protein phosphatase 1	0.0164	0.1615	0.2074
Loa Loa (eye worm)	STE/STE7/MEK7 protein kinase	0.0142	0.1382	0.3246
Echinococcus multilocularis	ecdysone induced protein 78C	0.0012	0.0015	0.0015
Schistosoma mansoni	hypothetical protein	0.0057	0.0491	0.1152
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0012	0.0015	0.0036
Onchocerca volvulus	Protein phosphatase PP2A 55 kDa regulatory subunit homolog	0.0072	0.065	0.0842
Echinococcus granulosus	inositol monophosphatase 1	0.0044	0.035	0.0821
Trichomonas vaginalis	protein phosphatase-7, putative	0.0206	0.2058	1
Trichomonas vaginalis	protein phosphatase-7, putative	0.0206	0.2058	1
Trypanosoma brucei	protein phosphatase 1	0.0164	0.1615	0.2074
Trichomonas vaginalis	protein phosphatase-5, putative	0.0206	0.2058	1
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0022	0.0124	0.0159
Trichomonas vaginalis	bsu-protein phosphatase, putative	0.005	0.0418	0.2032
Trichomonas vaginalis	protein phosphatase-1, putative	0.005	0.0418	0.2032
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0015	0.0036
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0012	0.0015	0.0036
Trichomonas vaginalis	inositol monophosphatase, putative	0.0044	0.035	0.1699
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0022	0.0124	0.5
Echinococcus multilocularis	serine:threonine protein phosphatase PP1 isozyme	0.005	0.0418	0.0418
Echinococcus granulosus	protein phosphatase 1 catalytic subunit	0.005	0.0418	0.0982
Giardia lamblia	Phosphatase	0.0011	0.0001	0.0016
Trichomonas vaginalis	protein phosphatase-1, putative	0.0206	0.2058	1
Trypanosoma brucei	protein phosphatase 1, putative	0.005	0.0418	0.0537
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0022	0.0124	0.1904
Loa Loa (eye worm)	hypothetical protein	0.0145	0.1417	0.3326
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0012	0.0015	0.0036
Loa Loa (eye worm)	STE/STE7/MEK7 protein kinase	0.0142	0.1382	0.3246
Trichomonas vaginalis	bsu-protein phosphatase, putative	0.02	0.1992	0.9677
Echinococcus multilocularis	protein phosphatase 1 catalytic subunit	0.0011	0.0001	0.0001
Trichomonas vaginalis	bsu-protein phosphatase, putative	0.005	0.0418	0.2032
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0044	0.035	0.1699
Trypanosoma cruzi	serine/threonine-protein phosphatase PP1 alpha	0.0246	0.2476	0.318
Loa Loa (eye worm)	serine/threonine protein phosphatase PP1-beta catalytic subunit	0.005	0.0418	0.0982
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0012	0.0015	0.0036
Trichomonas vaginalis	protein phosphatase, caeel, putative	0.0206	0.2058	1
Onchocerca volvulus	Huntingtin homolog	0.0145	0.1417	0.1835
Schistosoma mansoni	protein phosphatase-1	0.005	0.0418	0.0982
Wolbachia endosymbiont of Brugia malayi	fructose-1,6-bisphosphatase	0.0044	0.035	1
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0012	0.0015	0.002
Giardia lamblia	Ser/Thr protein phosphatase PP1-alpha 2 catalytic subunit	0.005	0.0418	0.6438
Trichomonas vaginalis	protein phosphatase-7, putative	0.0206	0.2058	1
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0015	0.0036
Trichomonas vaginalis	serine/threonine protein phosphatase, putative	0.0206	0.2058	1
Onchocerca volvulus	Bile acid receptor homolog	0.0012	0.0015	0.002
Brugia malayi	hypothetical protein	0.0145	0.1417	0.3326
Echinococcus multilocularis	serine:threonine protein phosphatase PP1 gamma	0.005	0.0418	0.0418
Loa Loa (eye worm)	serine/threonine protein phosphatase 2A	0.0072	0.065	0.1526
Loa Loa (eye worm)	hypothetical protein	0.02	0.1992	0.4677
Trichomonas vaginalis	serine/threonine protein phosphatase, putative	0.0011	0.0001	0.0005
Trichomonas vaginalis	protein phosphatase-7, putative	0.0206	0.2058	1
Entamoeba histolytica	myo-inositol monophosphatase, putative	0.0044	0.035	0.5382
Echinococcus granulosus	protein phosphatase 2a regulatory subunit	0.002	0.0099	0.0232
Brugia malayi	Serine/threonine protein phosphatase 2A, 56 kDa regulatory subunit,epsilon isoform	0.002	0.0099	0.0232
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0022	0.0124	0.0159
Schistosoma mansoni	protein tyrosine phosphatase non-receptor type nt1	0.0416	0.4259	1
Leishmania major	serine/threonine-protein phosphatase PP1, putative	0.0246	0.2476	0.318
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0022	0.0124	0.0124
Brugia malayi	steroid hormone receptor	0.0012	0.0015	0.0036
Trichomonas vaginalis	protein phosphatase-2B, putative	0.0206	0.2058	1
Trichomonas vaginalis	protein phosphatase-7, caeel, putative	0.0206	0.2058	1
Trichomonas vaginalis	serine/threonine protein phosphatase, putative	0.005	0.0418	0.2032
Brugia malayi	nuclear hormone receptor	0.0012	0.0015	0.0036
Echinococcus multilocularis	protein phosphatase pp2a regulatory subunit b	0.0072	0.065	0.065
Trichomonas vaginalis	protein phsophatase-2A, putative	0.0206	0.2058	1
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0015	0.0036
Trichomonas vaginalis	protein phosphatase, caeel, putative	0.005	0.0418	0.2032
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0012	0.0015	0.0036
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0012	0.0015	0.0015
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0416	0.4259	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0012	0.0015	0.0036
Trichomonas vaginalis	bsu-protein phosphatase, putative	0.0206	0.2058	1
Trichomonas vaginalis	protein phsophatase-2A, putative	0.0206	0.2058	1
Trichomonas vaginalis	protein phosphatase-5, putative	0.0206	0.2058	1
Leishmania major	serine/threonine protein phosphatase catalytic subunit, putative	0.005	0.0418	0.0537
Leishmania major	serine/threonine-protein phosphatase PP1, putative	0.0046	0.0373	0.0479
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0012	0.0015	0.0036
Loa Loa (eye worm)	hypothetical protein	0.0206	0.2058	0.4833
Echinococcus multilocularis	serine:threonine protein phosphatase 2A 56 kDa	0.002	0.0099	0.0099
Echinococcus multilocularis	serine:threonine protein phosphatase PP1 beta	0.005	0.0418	0.0418
Trypanosoma cruzi	serine/threonine-protein phosphatase PP1, putative	0.0246	0.2476	0.318
Trichomonas vaginalis	protein phosphatase-1, putative	0.0206	0.2058	1
Loa Loa (eye worm)	hypothetical protein	0.0206	0.2058	0.4833
Loa Loa (eye worm)	hypothetical protein	0.0206	0.2058	0.4833
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0022	0.0124	0.0159
Schistosoma mansoni	protein phosphatase type 1	0.005	0.0418	0.0982
Trichomonas vaginalis	protein phsophatase-2A, putative	0.0206	0.2058	1
Entamoeba histolytica	serine/threonine protein phosphatase PP1-2, putative	0.0011	0.0001	0.0016
Trichomonas vaginalis	protein phosphatase 2A, caeel, putative	0.0206	0.2058	1
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0012	0.0015	0.0036
Onchocerca volvulus		0.0206	0.2058	0.2666
Trichomonas vaginalis	protein phosphatase, caeel, putative	0.0206	0.2058	1
Trichomonas vaginalis	protein phosphatase-1, putative	0.0046	0.0373	0.1812
Loa Loa (eye worm)	protein phosphatase 2A regulatory subunit B' delta isoform	0.002	0.0099	0.0232
Loa Loa (eye worm)	inositol-1	0.0044	0.035	0.0821
Echinococcus multilocularis	dual specificity mitogen activated protein	0.0142	0.1382	0.1382
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0012	0.0015	0.0036
Giardia lamblia	Protein phosphatase 2A B regulatory subunit Wdb1	0.002	0.0099	0.1518
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0012	0.0015	0.0015
Trichomonas vaginalis	serine/threonine protein phosphatase, putative	0.0206	0.2058	1
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0012	0.0015	0.0036
Trichomonas vaginalis	serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform, putative	0.0072	0.065	0.3157
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0012	0.0015	0.0036
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0022	0.0124	0.1904
Trypanosoma cruzi	serine/threonine-protein phosphatase PP1 beta	0.0751	0.7787	1
Trichomonas vaginalis	protein phosphatase, caeel, putative	0.0206	0.2058	1
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0012	0.0015	0.0036
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0416	0.4259	0.4259
Onchocerca volvulus		0.0012	0.0015	0.002
Trypanosoma brucei	protein phoshatase 1, putative	0.0751	0.7787	1
Brugia malayi	Serine/threonine protein phosphatase PP1 isozyme 1, putative	0.0046	0.0373	0.0876
Trypanosoma cruzi	serine/threonine-protein phosphatase PP1, putative	0.0246	0.2476	0.318
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0012	0.0015	0.0036
Echinococcus multilocularis	FTZ F1 alpha	0.0012	0.0015	0.0015
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0416	0.4259	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0072	0.065	0.0835
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0012	0.0015	0.0036
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0012	0.0015	0.0036
Brugia malayi	Serine/threonine protein phosphatase F56C9.1 in chromosomeIII	0.005	0.0418	0.0982
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0012	0.0015	0.0036
Leishmania major	serine/threonine protein phosphatase pp1(5.9), putative	0.0164	0.1615	0.2074
Trichomonas vaginalis	phosphoserine/threonine phosphatase, putative	0.0206	0.2058	1
Onchocerca volvulus		0.0745	0.772	1
Trichomonas vaginalis	protein phosphatase-1, putative	0.0206	0.2058	1
Trichomonas vaginalis	protein phosphatase 2A, caeel, putative	0.0206	0.2058	1
Trypanosoma cruzi	serine/threonine-protein phosphatase PP1, putative	0.0751	0.7787	1
Schistosoma mansoni	protein phosphatase-1	0.0206	0.2058	0.4833
Trichomonas vaginalis	protein phsophatase-2A, putative	0.0206	0.2058	1
Trichomonas vaginalis	phosphoserine/threonine phosphatase, putative	0.0206	0.2058	1
Loa Loa (eye worm)	serine/threonine protein phosphatase PP1 isozyme 1	0.0046	0.0373	0.0876
Trichomonas vaginalis	protein phosphatase, caeel, putative	0.0206	0.2058	1
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0012	0.0015	0.0015
Onchocerca volvulus	Huntingtin homolog	0.0145	0.1417	0.1835
Trypanosoma brucei	serine threonine-protein phosphatase PP1, putative	0.0046	0.0373	0.0479
Brugia malayi	Nuclear hormone receptor-like 1	0.0012	0.0015	0.0036
Brugia malayi	Serine/threonine protein phosphatase PP1-alpha catalytic subunit	0.0046	0.0373	0.0876
Trichomonas vaginalis	serine/threonine protein phosphatase, putative	0.0206	0.2058	1
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0012	0.0015	0.0015
Brugia malayi	photoreceptor-specific nuclear receptor	0.0012	0.0015	0.0036
Mycobacterium ulcerans	extragenic suppressor protein SuhB	0.0044	0.035	1
Trichomonas vaginalis	ap endonuclease, putative	0.0022	0.0124	0.0601
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0012	0.0015	0.0036
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0012	0.0015	0.0036
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0012	0.0015	0.0036
Schistosoma mansoni	thyroid hormone receptor	0.0012	0.0015	0.0036
Schistosoma mansoni	protein phosphatase 2a regulatory subunit	0.002	0.0099	0.0232
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0057	0.0491	0.1152
Loa Loa (eye worm)	serine/threonine protein phosphatase PP1 isozyme 1	0.0046	0.0373	0.0876
Plasmodium falciparum	serine/threonine protein phosphatase PP1	0.005	0.0418	1
Loa Loa (eye worm)	steroid hormone receptor	0.0012	0.0015	0.0036
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0015	0.0036
Onchocerca volvulus	Protein ultraspiracle homolog	0.0012	0.0015	0.002

Activities

Activity type	Activity value	Assay description	Source	Reference
Activity (functional)	= 47 %	Antagonistic blocking activity at alpha adrenergic receptor by NE induced contractions of the epididymal portion of isolated rat vas deferens at the dose of 20 microM	ChEMBL.	2999398
Activity (functional)	= 47 %	Antagonistic blocking activity at alpha adrenergic receptor by NE induced contractions of the epididymal portion of isolated rat vas deferens at the dose of 20 microM	ChEMBL.	2999398

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 63324