TDR Targets

Basic information

Technical information

TDR Targets ID: 647410
Name: N'-(2-chlorophenyl)-N-(phenylmethyl)oxamide
MW: 288.729 | Formula: C15H13ClN2O2
H donors: 2 H acceptors: 2 LogP: 2.93 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: O=C(C(=O)NCc1ccccc1)Nc1ccccc1Cl
InChi: 1S/C15H13ClN2O2/c16-12-8-4-5-9-13(12)18-15(20)14(19)17-10-11-6-2-1-3-7-11/h1-9H,10H2,(H,17,19)(H,18,20)
InChiKey: UDLORWBWKUVQJW-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-(benzyl)-N'-(2-chlorophenyl)oxamide
N'-(2-chlorophenyl)-N-(phenylmethyl)ethanediamide
STK169002
ZINC02860380

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Oryctolagus cuniculus	Glycogen phosphorylase, muscle form	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus multilocularis	glycogen phosphorylase	Get druggable targets OG5_126999	All targets in OG5_126999
Cryptosporidium parvum	glycogen phosphorylase	Get druggable targets OG5_126999	All targets in OG5_126999
Schistosoma japonicum	ko:K00688 starch phosphorylase [EC2.4.1.1], putative	Get druggable targets OG5_126999	All targets in OG5_126999
Entamoeba histolytica	glycogen phosphorylase, putative	Get druggable targets OG5_126999	All targets in OG5_126999
Cryptosporidium hominis	glycogen phosphorylase 1	Get druggable targets OG5_126999	All targets in OG5_126999
Echinococcus granulosus	glycogen phosphorylase	Get druggable targets OG5_126999	All targets in OG5_126999
Echinococcus granulosus	glycogen phosphorylase	Get druggable targets OG5_126999	All targets in OG5_126999
Entamoeba histolytica	glycogen phosphorylase, putative	Get druggable targets OG5_126999	All targets in OG5_126999
Candida albicans	hypothetical protein	Get druggable targets OG5_126999	All targets in OG5_126999
Chlamydia trachomatis	glycogen phosphorylase	Get druggable targets OG5_126999	All targets in OG5_126999
Candida albicans	glycogen phosphorylase	Get druggable targets OG5_126999	All targets in OG5_126999
Schistosoma japonicum	Glycogen phosphorylase, brain form, putative	Get druggable targets OG5_126999	All targets in OG5_126999
Schistosoma japonicum	ko:K00688 starch phosphorylase [EC2.4.1.1], putative	Get druggable targets OG5_126999	All targets in OG5_126999
Echinococcus granulosus	Glycosyl transferase family 35	Get druggable targets OG5_126999	All targets in OG5_126999
Trichomonas vaginalis	glycogen phosphorylase, putative	Get druggable targets OG5_126999	All targets in OG5_126999
Echinococcus multilocularis	glycogen phosphorylase	Get druggable targets OG5_126999	All targets in OG5_126999
Brugia malayi	carbohydrate phosphorylase	Get druggable targets OG5_126999	All targets in OG5_126999
Loa Loa (eye worm)	glycogen phosphorylase	Get druggable targets OG5_126999	All targets in OG5_126999
Schistosoma mansoni	glycogen phosphorylase	Get druggable targets OG5_126999	All targets in OG5_126999
Onchocerca volvulus	Glycogen phosphorylase homolog	Get druggable targets OG5_126999	All targets in OG5_126999
Schistosoma mansoni	glycogen phosphorylase	Get druggable targets OG5_126999	All targets in OG5_126999
Neospora caninum	hypothetical protein	Get druggable targets OG5_126999	All targets in OG5_126999
Trichomonas vaginalis	glycogen phosphorylase, putative	Get druggable targets OG5_126999	All targets in OG5_126999
Giardia lamblia	Glycogen phosphorylase	Get druggable targets OG5_126999	All targets in OG5_126999
Echinococcus multilocularis	Glycosyl transferase, family 35	Get druggable targets OG5_126999	All targets in OG5_126999

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Onchocerca volvulus		Glycogen phosphorylase, muscle form	843 aa	840 aa	70.2 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	Cathepsin L-like precursor	0.0017	0.0242	0.0665
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0028	0.0537	0.1616
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0036	0.0718	0.2209
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0103	0.0195
Loa Loa (eye worm)	CYP4Cod1	0.0014	0.0177	0.0437
Echinococcus granulosus	cathepsin L cysteine protease	0.0009	0.0039	0.0039
Plasmodium vivax	vivapain-2	0.0017	0.0242	0.2991
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0017	0.0242	0.0665
Onchocerca volvulus	Glycogen phosphorylase homolog	0.013	0.3098	1
Schistosoma mansoni	cpg binding protein	0.0028	0.0537	0.0537
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0017	0.0242	0.0665
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0011	0.0103	0.0211
Trypanosoma brucei	cytochrome P450, putative	0.0014	0.0177	0.1002
Mycobacterium ulcerans	lipase LipD	0.0036	0.0718	0.5098
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0242	0.0665
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.0718	0.4919
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0019	0.0294	0.0217
Entamoeba histolytica	glycogenphosphorylase, putative	0.0056	0.1239	0.3923
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0017	0.0242	0.0242
Toxoplasma gondii	cathepsin CPL	0.0017	0.0242	0.0649
Loa Loa (eye worm)	fibroinase	0.0017	0.0242	0.0649
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0242	0.0665
Trichomonas vaginalis	ap endonuclease, putative	0.0019	0.0294	0.0834
Mycobacterium tuberculosis	Conserved protein	0.0036	0.0718	0.1008
Entamoeba histolytica	glycogen phosphorylase, putative	0.013	0.3098	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0017	0.0242	0.0242
Leishmania major	cathepsin L-like protease	0.0017	0.0242	0.0521
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0017	0.0242	0.0665
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0017	0.0242	0.0665
Trichomonas vaginalis	glycogen phosphorylase, putative	0.013	0.3098	1
Trypanosoma cruzi	cytochrome P450, putative	0.0014	0.0177	0.1002
Mycobacterium tuberculosis	Probable lipase LipE	0.0036	0.0718	0.1008
Leishmania major	cathepsin L-like protease	0.0064	0.142	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0064	0.142	1
Onchocerca volvulus		0.0017	0.0242	0.0463
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0017	0.0242	0.0242
Entamoeba histolytica	glycogen phosphorylase, putative	0.013	0.3098	1
Trichomonas vaginalis	penicillin-binding protein, putative	0.0036	0.0718	0.2222
Schistosoma mansoni	cathepsin F (C01 family)	0.0011	0.0103	0.0103
Mycobacterium tuberculosis	Conserved protein	0.0036	0.0718	0.1008
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0242	0.0665
Entamoeba histolytica	glycogen phosphorylase, putative	0.0056	0.1239	0.3923
Brugia malayi	beta-lactamase	0.0036	0.0718	0.2222
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0036	0.0718	0.0718
Echinococcus multilocularis	cpg binding protein	0.003	0.0578	0.0578
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0242	0.0665
Trichomonas vaginalis	esterase, putative	0.0036	0.0718	0.2222
Trypanosoma brucei	Lanosterol 14-alpha demethylase	0.0014	0.0177	0.1002
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0019	0.0294	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0009	0.0039	0.0039
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0064	0.142	1
Schistosoma mansoni	ap endonuclease	0.0019	0.0294	0.0294
Echinococcus granulosus	glycogen phosphorylase	0.013	0.3098	0.3098
Leishmania major	hypothetical protein, conserved	0.0036	0.0718	0.4353
Trichomonas vaginalis	ap endonuclease, putative	0.0019	0.0294	0.0834
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0054	0.1176	1
Onchocerca volvulus		0.0017	0.0242	0.0463
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0064	0.142	1
Schistosoma mansoni	ap endonuclease	0.0019	0.0294	0.0294
Trichomonas vaginalis	D-aminoacylase, putative	0.0036	0.0718	0.2222
Giardia lamblia	Glycogen phosphorylase	0.013	0.3098	1
Onchocerca volvulus	Cathepsin F homolog	0.0017	0.0242	0.0463
Brugia malayi	carbohydrate phosphorylase	0.013	0.3098	1
Brugia malayi	Cytochrome P450 family protein	0.0014	0.0177	0.0453
Trypanosoma cruzi	Lanosterol 14-alpha demethylase	0.0014	0.0177	0.1002
Onchocerca volvulus	Cathepsin L homolog	0.0017	0.0242	0.0463
Schistosoma mansoni	glycogen phosphorylase	0.013	0.3098	0.3098
Onchocerca volvulus		0.0017	0.0242	0.0463
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0036	0.0718	0.1008
Schistosoma mansoni	hypothetical protein	0.0168	0.4039	0.4039
Echinococcus multilocularis	cathepsin L cysteine protease	0.0017	0.0242	0.0242
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0036	0.0718	0.5098
Brugia malayi	cathepsin L-like precursor	0.0011	0.0103	0.0211
Loa Loa (eye worm)	ctsf protein	0.0017	0.0242	0.0649
Mycobacterium tuberculosis	Conserved protein	0.0036	0.0718	0.1008
Echinococcus granulosus	cysteine protease	0.0009	0.0039	0.0039
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0242	0.0665
Leishmania major	cathepsin L-like protease	0.0017	0.0242	0.0521
Plasmodium vivax	vivapain-2	0.0017	0.0242	0.2991
Loa Loa (eye worm)	glycogen phosphorylase	0.013	0.3098	1
Entamoeba histolytica	cysteine proteinase, putative	0.0011	0.0103	0.0211
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0019	0.0294	0.5
Echinococcus granulosus	cathepsin l1	0.0011	0.0103	0.0103
Leishmania major	cathepsin L-like protease	0.0064	0.142	1
Schistosoma mansoni	glycogen phosphorylase	0.013	0.3098	0.3098
Echinococcus multilocularis	cathepsin L cysteine protease	0.0017	0.0242	0.0242
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0009	0.0044	0.0044
Plasmodium vivax	hypothetical protein, conserved	0.0036	0.0718	1
Loa Loa (eye worm)	cysteine protease	0.0017	0.0242	0.0649
Toxoplasma gondii	ABC1 family protein	0.0036	0.0718	0.5417
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0242	0.0665
Echinococcus multilocularis	geminin	0.0168	0.4039	0.4039
Schistosoma mansoni	cathepsin F (C01 family)	0.0017	0.0242	0.0242
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0011	0.0103	0.0211
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0242	0.0665
Onchocerca volvulus		0.0017	0.0242	0.0463
Trypanosoma cruzi	cruzipain precursor, putative	0.0064	0.142	1
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0036	0.0718	0.1008
Trypanosoma cruzi	cytochrome p450-like protein, putative	0.0014	0.0177	0.1002
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0242	0.0665
Trichomonas vaginalis	D-aminoacylase, putative	0.0036	0.0718	0.2222
Schistosoma mansoni	cpg binding protein	0.003	0.0578	0.0578
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0718	0.2209
Schistosoma mansoni	hypothetical protein	0.0168	0.4039	0.4039
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0718	0.2209
Brugia malayi	CXXC zinc finger family protein	0.0028	0.0537	0.1629
Echinococcus granulosus	beta LACTamase domain containing family member	0.0036	0.0718	0.0718
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0242	0.0649
Brugia malayi	Cathepsin L-like precursor	0.0011	0.0103	0.0211
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0019	0.0294	0.0834
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0242	0.0665
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0103	0.0195
Leishmania major	cathepsin L-like protease	0.0017	0.0242	0.0521
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0017	0.0242	0.0665
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.006	0.1338	0.1338
Trichomonas vaginalis	glycogen phosphorylase, putative	0.013	0.3098	1
Brugia malayi	Cytochrome P450 family protein	0.0014	0.0177	0.0453
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0009	0.0039	0.0039
Schistosoma mansoni	glycogen phosphorylase	0.0056	0.1239	0.1239
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0718	0.2209
Mycobacterium leprae	Probable lipase LipE	0.0036	0.0718	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0242	0.0665
Leishmania major	cathepsin L-like protease	0.0017	0.0242	0.0521
Entamoeba histolytica	glycogen phosphorylase, putative	0.0056	0.1239	0.3923
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0036	0.0718	0.1008
Loa Loa (eye worm)	beta-lactamase	0.0036	0.0718	0.2209
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0019	0.0294	0.0294
Trypanosoma cruzi	Lanosterol 14-alpha demethylase	0.0014	0.0177	0.1002
Entamoeba histolytica	cysteine proteinase, putative	0.0017	0.0242	0.0665
Mycobacterium ulcerans	beta-lactamase	0.0036	0.0718	0.5098
Brugia malayi	beta-lactamase family protein	0.0036	0.0718	0.2222
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.0718	0.4919
Mycobacterium ulcerans	esterase/lipase LipP	0.0036	0.0718	0.5098
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0058	0.1282	0.8997
Onchocerca volvulus		0.0017	0.0242	0.0463
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0017	0.0242	0.7974
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0064	0.142	1
Loa Loa (eye worm)	cytochrome P450 family protein	0.0052	0.1133	0.3566
Leishmania major	cathepsin L-like protease	0.0064	0.142	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0017	0.0242	0.0665
Mycobacterium tuberculosis	Probable esterase LipL	0.0036	0.0718	0.1008
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0064	0.142	1
Brugia malayi	Cathepsin L-like precursor	0.0017	0.0242	0.0665
Brugia malayi	Papain family cysteine protease containing protein	0.0017	0.0242	0.0665
Schistosoma mansoni	cytochrome P450	0.0014	0.0177	0.0177
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0064	0.142	1
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0019	0.0294	0.1097
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0718	0.2209
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0036	0.0718	0.0718
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0009	0.0039	0.0039
Brugia malayi	Cathepsin L-like precursor	0.0011	0.0103	0.0211
Brugia malayi	F/Y-rich N-terminus family protein	0.0009	0.0041	0.0007
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0036	0.0718	0.2222
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0064	0.142	1
Loa Loa (eye worm)	cytochrome P450 family protein	0.0014	0.0177	0.0437
Echinococcus granulosus	cathepsin L	0.0009	0.0039	0.0039
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0019	0.0294	0.1845
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0019	0.0294	0.5
Onchocerca volvulus		0.0036	0.0718	0.2054
Echinococcus granulosus	Glycosyl transferase family 35	0.013	0.3098	0.3098
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0064	0.142	1
Trypanosoma cruzi	major cysteine proteinase, putative	0.005	0.1078	0.7525
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0718	0.2209
Schistosoma mansoni	cpg binding protein	0.003	0.0578	0.0578
Trypanosoma cruzi	cysteine peptidase, putative	0.0064	0.142	1
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0718	0.2209
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0019	0.0294	0.1845
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0064	0.142	1
Trichomonas vaginalis	D-aminoacylase, putative	0.0036	0.0718	0.2222
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0017	0.0242	0.7974
Trypanosoma cruzi	cysteine peptidase, putative	0.0017	0.0242	0.1472
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0011	0.0103	0.0211
Echinococcus multilocularis	cysteine protease	0.0017	0.0242	0.0242
Brugia malayi	exodeoxyribonuclease III family protein	0.0019	0.0294	0.0834
Schistosoma mansoni	hypothetical protein	0.0014	0.0177	0.0177
Brugia malayi	Cathepsin L-like precursor	0.0017	0.0242	0.0665
Brugia malayi	Cytochrome P450 family protein	0.0014	0.0177	0.0453
Echinococcus multilocularis		0.0014	0.0177	0.0177
Echinococcus multilocularis	glycogen phosphorylase	0.013	0.3098	0.3098
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0017	0.0242	0.0665
Brugia malayi	Cytochrome P450 family protein	0.0052	0.1133	0.3577
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0019	0.0294	0.0818
Echinococcus granulosus	cytochrome P450 2K1	0.0014	0.0177	0.0177
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0017	0.0242	0.0242
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0242	0.0665
Leishmania major	cysteine peptidase A (CPA)	0.0017	0.0242	0.0521
Onchocerca volvulus		0.0017	0.0242	0.0463
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0017	0.0242	0.7974
Brugia malayi	beta-lactamase family protein	0.0036	0.0718	0.2222
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0242	0.0665
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0228	0.5546	1
Echinococcus granulosus	geminin	0.0168	0.4039	0.4039
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0017	0.0242	0.0665
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0019	0.0294	0.0937
Brugia malayi	Cathepsin L-like precursor	0.0017	0.0242	0.0665
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0019	0.0294	0.1845
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0064	0.142	1
Onchocerca volvulus		0.0036	0.0718	0.2054
Echinococcus multilocularis	cysteine protease	0.0017	0.0242	0.0242
Trypanosoma cruzi	cysteine peptidase, putative	0.0064	0.142	1
Mycobacterium tuberculosis	Probable glycogen phosphorylase GlgP	0.0056	0.1239	0.1977
Echinococcus granulosus	cathepsin l1	0.0017	0.0242	0.0242
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0017	0.0242	0.0649
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0009	0.0044	0.0044
Echinococcus granulosus	cpg binding protein	0.003	0.0578	0.0578
Echinococcus multilocularis	glycogen phosphorylase	0.013	0.3098	0.3098
Echinococcus granulosus	glycogen phosphorylase	0.013	0.3098	0.3098
Echinococcus multilocularis	cathepsin L	0.0009	0.0039	0.0039
Brugia malayi	Cathepsin L-like precursor	0.0017	0.0242	0.0665
Entamoeba histolytica	cysteine proteinase, putative	0.0017	0.0242	0.0665
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0019	0.0294	0.0294
Trypanosoma cruzi	cytochrome P450, putative	0.0014	0.0177	0.1002
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0242	0.0665
Echinococcus multilocularis	dnaJ subfamily B	0.0405	1	1
Trypanosoma brucei	hypothetical protein, conserved	0.0036	0.0718	0.4919
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0017	0.0242	0.0665
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0036	0.0718	0.0718
Loa Loa (eye worm)	cytochrome P450 family protein	0.0014	0.0177	0.0437
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0103	0.0195
Schistosoma mansoni	hypothetical protein	0.0405	1	1
Brugia malayi	cytochrome P450	0.0014	0.0177	0.0453
Chlamydia trachomatis	glycogen phosphorylase	0.013	0.3098	0.5
Trichomonas vaginalis	penicillin-binding protein, putative	0.0036	0.0718	0.2222
Onchocerca volvulus		0.0028	0.0537	0.1449
Mycobacterium leprae	conserved hypothetical protein	0.0036	0.0718	1
Mycobacterium tuberculosis	Probable lipase LipD	0.0036	0.0718	0.1008
Loa Loa (eye worm)	cytochrome P450	0.0014	0.0177	0.0437
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0017	0.0242	0.0242
Trypanosoma cruzi	cysteine peptidase, putative	0.0064	0.142	1
Onchocerca volvulus	Cathepsin L homolog	0.0017	0.0242	0.0463
Brugia malayi	Cathepsin L-like precursor	0.0017	0.0242	0.0665
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0017	0.0242	0.0665
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0064	0.142	1
Mycobacterium ulcerans	glycogen phosphorylase GlgP	0.0056	0.1239	1
Onchocerca volvulus		0.0036	0.0718	0.2054
Toxoplasma gondii	exonuclease III APE	0.0019	0.0294	0.1166
Entamoeba histolytica	cysteine protease, putative	0.0017	0.0242	0.0665
Leishmania major	cathepsin L-like protease	0.0017	0.0242	0.0521
Mycobacterium ulcerans	hypothetical protein	0.0036	0.0718	0.5098
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0017	0.0242	0.0649
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0242	0.0665
Onchocerca volvulus		0.0017	0.0242	0.0463
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0017	0.0242	0.0665
Mycobacterium tuberculosis	Probable hydrolase	0.0036	0.0718	0.1008
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0019	0.0294	0.3751
Echinococcus multilocularis	Glycosyl transferase, family 35	0.013	0.3098	0.3098

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 3 uM	Inhibition of rabbit muscle glycogen phosphorylase 1a assessed as release of phosphate from glucose-1- phosphate after 20 mins	ChEMBL.	21788139
Inhibition (binding)	= 64 %	Inhibition of rabbit muscle glycogen phosphorylase 1a assessed as release of phosphate from glucose-1- phosphate at 10 uM after 20 mins	ChEMBL.	21788139

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1814684
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Bibliographic References

No literature references available for this target.

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Detailed information for compound 647410