Detailed information for compound 648317

Basic information

Technical information
  • TDR Targets ID: 648317
  • Name: 5-(4-bromophenyl)-N-(3-nitrophenyl)furan-2-ca rboxamide
  • MW: 387.184 | Formula: C17H11BrN2O4
  • H donors: 1 H acceptors: 3 LogP: 4.34 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Brc1ccc(cc1)c1ccc(o1)C(=O)Nc1cccc(c1)[N+](=O)[O-]
  • InChi: 1S/C17H11BrN2O4/c18-12-6-4-11(5-7-12)15-8-9-16(24-15)17(21)19-13-2-1-3-14(10-13)20(22)23/h1-10H,(H,19,21)
  • InChiKey: JYQRTDXQKIJUDT-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 5-(4-bromophenyl)-N-(3-nitrophenyl)-2-furancarboxamide
  • 5-(4-bromophenyl)-N-(3-nitrophenyl)-2-furamide
  • ZINC01185899
  • STK255765

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0199 0.0428
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0199 0.0165
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0199 0.0165
Brugia malayi hypothetical protein 0.0009 0.0067 0.007
Brugia malayi hypothetical protein 0.0009 0.0067 0.007
Schistosoma mansoni hypothetical protein 0.0011 0.0089 0.0104
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.003 0.0000000024489
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0011 0.0091 0.0834
Loa Loa (eye worm) nuclear hormone receptor 0.0009 0.0067 0.0137
Loa Loa (eye worm) hypothetical protein 0.0009 0.0067 0.0137
Loa Loa (eye worm) hypothetical protein 0.0023 0.0242 0.0524
Loa Loa (eye worm) hypothetical protein 0.0009 0.0067 0.0137
Echinococcus multilocularis bloom syndrome protein 0.0021 0.0215 0.0181
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0288 0.0625
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0199 0.0364
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0007 0.0035 0.0431
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0081 0.0094
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0199 0.0364
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0009 0.0059 0.0024
Echinococcus granulosus thyroid hormone receptor alpha 0.0009 0.0067 0.0037
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.001 0.0081 0.0094
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0199 0.0364
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0242 0.3091
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0199 0.0165
Loa Loa (eye worm) DR-78 0.0009 0.0067 0.0137
Onchocerca volvulus 0.0009 0.0067 0.1167
Echinococcus granulosus bloom syndrome protein 0.0021 0.0215 0.0211
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0007 0.0035 0.0175
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0746 0.0871
Echinococcus granulosus muscleblind protein 0.0148 0.1829 0.2104
Echinococcus granulosus GPCR family 2 0.0031 0.0341 0.0359
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0288 0.0625
Trichomonas vaginalis antibiotic synthetase, putative 0.0007 0.0035 0.0274
Echinococcus multilocularis lamin dm0 0.0027 0.0288 0.0254
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0242 1
Schistosoma mansoni lamin 0.0027 0.0288 0.0336
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0746 0.0871
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0242 1
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0112 0.0091
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0059 0.0768
Brugia malayi Bloom's syndrome protein homolog 0.0021 0.0215 0.04
Loa Loa (eye worm) hypothetical protein 0.0067 0.0796 0.1746
Brugia malayi intermediate filament protein 0.0027 0.0288 0.0562
Echinococcus granulosus lamin 0.0027 0.0288 0.0297
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0706 1
Echinococcus granulosus intermediate filament protein 0.0027 0.0288 0.0297
Brugia malayi nuclear hormone receptor family member nhr-6 0.0009 0.0067 0.007
Brugia malayi Nuclear hormone receptor E75 0.0009 0.0067 0.007
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0059 0.0053
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0089 0.0063
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0242 0.0461
Loa Loa (eye worm) hypothetical protein 0.0009 0.0059 0.0119
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0199 0.0232
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.003 0.0000000024489
Loa Loa (eye worm) hypothetical protein 0.0009 0.0067 0.0137
Loa Loa (eye worm) hypothetical protein 0.0009 0.0067 0.0137
Onchocerca volvulus 0.0023 0.0242 0.7627
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0341 0.0359
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0059 0.0768
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0199 0.0192
Schistosoma mansoni lamin 0.0027 0.0288 0.0336
Loa Loa (eye worm) hypothetical protein 0.001 0.0081 0.0168
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0199 0.0364
Loa Loa (eye worm) hypothetical protein 0.0009 0.0067 0.0137
Schistosoma mansoni acetyl-CoA synthetase 0.0007 0.0035 0.0041
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0199 0.0232
Echinococcus multilocularis GPCR, family 2 0.0031 0.0341 0.0307
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0242 0.3091
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0341 0.0307
Loa Loa (eye worm) hypothetical protein 0.002 0.0199 0.0428
Loa Loa (eye worm) RecQ helicase 0.0021 0.0215 0.0464
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0199 0.0428
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0007 0.0035 0.118
Loa Loa (eye worm) hypothetical protein 0.0025 0.0261 0.0565
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0199 0.0428
Loa Loa (eye worm) hypothetical protein 0.0009 0.0067 0.0137
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.003 0.0000000024489
Echinococcus granulosus tar DNA binding protein 0.0063 0.0746 0.0834
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0199 0.0165
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0199 0.0364
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0009 0.0059 0.0028
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0199 0.0192
Trichomonas vaginalis DNA helicase recq, putative 0.0011 0.0091 0.3299
Schistosoma mansoni nuclear hormone receptor 0.002 0.0199 0.0232
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0199 0.0165
Loa Loa (eye worm) RNA binding protein 0.0063 0.0746 0.1635
Echinococcus granulosus dnaJ subfamily B 0.0403 0.5054 0.5886
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0288 0.0562
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0007 0.0035 0.0175
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0199 0.0165
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.0035 0.0175
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0009 0.0067 0.0032
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0059 0.0025
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0242 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0199 0.0364
Loa Loa (eye worm) hypothetical protein 0.001 0.0081 0.0168
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0007 0.0035 0.118
Plasmodium vivax acyl-CoA synthetase, putative 0.0017 0.0168 0.6408
Onchocerca volvulus Bile acid receptor homolog 0.002 0.0199 0.6023
Echinococcus multilocularis muscleblind protein 0.0148 0.1829 0.18
Brugia malayi conserved hypotetical protein 0.0009 0.0067 0.007
Brugia malayi Calcitonin receptor-like protein seb-1 0.0098 0.1189 0.2561
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0059 0.0053
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0242 0.3091
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0081 0.0102
Plasmodium vivax acetyl-CoA synthetase, putative 0.0007 0.0035 0.1252
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0341 0.0359
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0017 0.0168 0.5
Loa Loa (eye worm) TAR-binding protein 0.0063 0.0746 0.1635
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0199 0.0428
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0199 0.0364
Echinococcus multilocularis cpg binding protein 0.003 0.0327 0.0294
Loa Loa (eye worm) hypothetical protein 0.0017 0.0168 0.0361
Schistosoma mansoni DNA helicase recq5 0.0009 0.0059 0.0068
Loa Loa (eye worm) hypothetical protein 0.0023 0.0242 0.0524
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0242 0.3091
Brugia malayi latrophilin 2 splice variant baaae 0.0067 0.0796 0.169
Schistosoma mansoni nuclear receptor 0.0009 0.0067 0.0078
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.0035 0.0175
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0199 0.0364
Loa Loa (eye worm) hypothetical protein 0.002 0.0199 0.0428
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0007 0.0035 0.0175
Onchocerca volvulus 0.0009 0.0067 0.1167
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0007 0.0038 0.0044
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0059 0.0029
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0007 0.0035 0.0067
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0706 0.0825
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0009 0.0067 0.0037
Trichomonas vaginalis DNA helicase recq1, putative 0.0021 0.0215 1
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0007 0.0035 0.0175
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0199 0.0192
Trichomonas vaginalis antibiotic synthetase, putative 0.0007 0.0035 0.0274
Schistosoma mansoni beta-12-n-acetylglucosaminyltransferase II 0.0362 0.4539 0.5302
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.013 0.0212
Schistosoma mansoni hypothetical protein 0.0403 0.5054 0.5903
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0007 0.0035 0.0067
Echinococcus multilocularis dnaJ subfamily B 0.0403 0.5054 0.5036
Brugia malayi nuclear hormone receptor 0.0009 0.0067 0.007
Loa Loa (eye worm) hypothetical protein 0.0013 0.0112 0.0238
Brugia malayi TAR-binding protein 0.0063 0.0746 0.1578
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0009 0.0067 0.0078
Onchocerca volvulus 0.002 0.0199 0.6023
Schistosoma mansoni hypothetical protein 0.0031 0.0341 0.0398
Toxoplasma gondii propionate-CoA ligase 0.0007 0.0035 0.0431
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0242 0.3212
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0007 0.0035 0.118
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0341 0.068
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0009 0.0067 0.0032
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0199 0.0232
Loa Loa (eye worm) hypothetical protein 0.0031 0.0341 0.0742
Schistosoma mansoni blooms syndrome DNA helicase 0.0004 0.0005 0.0005
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0009 0.0067 0.0032
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0706 1
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0009 0.0059 0.1046
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0063 0.0746 0.1635
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0199 0.0428
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0112 0.0078
Loa Loa (eye worm) hypothetical protein 0.002 0.0199 0.0428
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0009 0.0059 0.0024
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0007 0.0035 0.0431
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0007 0.0035 0.0175
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0307 0.0667
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0199 0.0232
Brugia malayi hypothetical protein 0.0016 0.015 0.0256
Loa Loa (eye worm) hypothetical protein 0.0009 0.0067 0.0137
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0199 0.0364
Loa Loa (eye worm) hypothetical protein 0.0017 0.0168 0.0361
Loa Loa (eye worm) hypothetical protein 0.002 0.0199 0.0428
Loa Loa (eye worm) hypothetical protein 0.0026 0.0282 0.0611
Onchocerca volvulus 0.0027 0.0288 0.9301
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0199 0.0428
Loa Loa (eye worm) hypothetical protein 0.0148 0.1829 0.4023
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0081 0.0102
Loa Loa (eye worm) hypothetical protein 0.0017 0.0168 0.0361
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0746 0.0871
Echinococcus granulosus Nuclear hormone receptor HR96 0.0009 0.0067 0.0037
Schistosoma mansoni DNA helicase recq1 0.0009 0.0059 0.0068
Onchocerca volvulus 0.0028 0.0307 1
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0746 0.0871
Loa Loa (eye worm) hypothetical protein 0.001 0.0081 0.0168
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0009 0.0067 0.0137
Schistosoma mansoni coup transcription factor 0.002 0.0199 0.0232
Loa Loa (eye worm) hypothetical protein 0.002 0.0199 0.0428
Echinococcus granulosus cpg binding protein 0.003 0.0327 0.0343
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0242 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0098 0.1189 0.2611
Mycobacterium ulcerans hypothetical protein 0.0023 0.0242 0.3091
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0006 0.003 0.0000000024489
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0009 0.0067 0.0032
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0341 0.0307
Schistosoma mansoni hypothetical protein 0.0031 0.0341 0.0398
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0199 0.0232
Loa Loa (eye worm) hypothetical protein 0.0009 0.0067 0.0137
Echinococcus multilocularis muscleblind protein 1 0.0148 0.1829 0.18
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0199 0.0192
Echinococcus multilocularis nuclear receptor nhr 48 0.0009 0.0067 0.0032
Toxoplasma gondii aldehyde dehydrogenase 0.006 0.0706 1
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0242 0.3091
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0199 0.0428
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0242 0.0461
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0242 0.3091
Brugia malayi ecdysone receptor 0.0009 0.0067 0.007
Loa Loa (eye worm) hypothetical protein 0.0009 0.0067 0.0137
Brugia malayi steroid hormone receptor 0.002 0.0199 0.0364
Schistosoma mansoni hypothetical protein 0.0031 0.0341 0.0398
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.0035 0.0175
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0006 0.003 0.0000000024489
Loa Loa (eye worm) hypothetical protein 0.0009 0.0067 0.0137
Brugia malayi nuclear receptor NHR-67 0.0009 0.0067 0.007
Brugia malayi nuclear receptor NHR-88 0.0009 0.0067 0.007
Schistosoma mansoni cpg binding protein 0.0028 0.0307 0.0359
Echinococcus granulosus lamin dm0 0.0027 0.0288 0.0297
Brugia malayi ecdysteroid receptor 0.002 0.0199 0.0364
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0199 0.0165
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0341 0.0742
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.003 0.0000000024489
Echinococcus multilocularis microtubule associated protein 2 0.0679 0.8562 0.8557
Loa Loa (eye worm) hypothetical protein 0.0007 0.0035 0.0067
Loa Loa (eye worm) hypothetical protein 0.0362 0.4539 1
Brugia malayi Nuclear hormone receptor E75 0.0009 0.0067 0.007
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0011 0.0091 0.3364
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0261 1
Brugia malayi orphan nuclear receptor NR2E1 0.0009 0.0067 0.007
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.013 0.0277
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0199 0.0364
Echinococcus granulosus mixed lineage leukemia protein mll 0.0007 0.0038 0.0003
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0199 0.0364
Echinococcus granulosus nuclear receptor nhr 48 0.0009 0.0067 0.0037
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0089 0.0054
Brugia malayi Muscleblind-like protein 0.0148 0.1829 0.3982
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0261 0.3653
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.002 0.0199 0.6023
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0242 0.3091
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0261 1
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.0215 1
Schistosoma mansoni cpg binding protein 0.003 0.0327 0.0382
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0156 0.195
Brugia malayi UDP-GlcNAc:a-6-D-mannoside b1,2-N-acetylglucosaminyltransferase II 0.0362 0.4539 1
Echinococcus multilocularis tar DNA binding protein 0.0063 0.0746 0.0714
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.0035 0.0175
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0709 0.0828
Echinococcus granulosus Nuclear hormone receptor HR96 0.0009 0.0067 0.0037
Treponema pallidum ATP-dependent DNA helicase 0.0004 0.0005 0.5
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0261 1
Plasmodium falciparum acyl-CoA synthetase 0.0017 0.0168 0.5894
Schistosoma mansoni cpg binding protein 0.003 0.0327 0.0382
Loa Loa (eye worm) hypothetical protein 0.0007 0.0035 0.0067
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0261 1
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0014 0.0127 0.1737
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0007 0.0035 0.1349
Loa Loa (eye worm) hypothetical protein 0.0009 0.0067 0.0137
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.0168 0.2125
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0014 0.0129 0.488
Leishmania major hypothetical protein, conserved 0.0025 0.0261 0.3368
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0009 0.0059 0.0028
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0009 0.0059 0.0119
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0009 0.0067 0.0078
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0746 0.0871
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.0628 0.8878
Loa Loa (eye worm) hypothetical protein 0.0012 0.0106 0.0224
Brugia malayi nuclear receptor RXR 0.0009 0.0067 0.007
Schistosoma mansoni nuclear receptor 0.0009 0.0067 0.0078
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0007 0.0038 0.0003
Loa Loa (eye worm) hypothetical protein 0.0017 0.0161 0.0345
Schistosoma mansoni microtubule-associated protein tau 0.0679 0.8562 1
Brugia malayi RNA recognition motif domain containing protein 0.0063 0.0746 0.1578
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0007 0.0035 0.0175
Schistosoma mansoni hypothetical protein 0.0031 0.0341 0.0398
Schistosoma mansoni zinc finger protein 0.0009 0.0067 0.0078
Schistosoma mansoni nuclear receptor nhr-48 0.0009 0.0067 0.0078
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0156 0.195
Loa Loa (eye worm) oxidoreductase 0.0007 0.0035 0.0067
Echinococcus granulosus FTZ F1 alpha 0.002 0.0199 0.0192
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0242 0.3091
Brugia malayi nuclear hormone receptor family member odr-7 0.0009 0.0067 0.007
Schistosoma mansoni thyroid hormone receptor 0.002 0.0199 0.0232
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0058 0.0051
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0059 0.0121
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.001 0.0081 0.0168
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0199 0.0232
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0009 0.0067 0.1167
Loa Loa (eye worm) hypothetical protein 0.0009 0.0067 0.0137
Echinococcus granulosus alpha 16 mannosyl glycoprotein 0.0362 0.4539 0.5283
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.006 0.0706 1
Echinococcus multilocularis lamin 0.0027 0.0288 0.0254
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0007 0.0038 0.0003
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0156 0.195
Brugia malayi RNA binding protein 0.0063 0.0746 0.1578
Brugia malayi tailless protein 0.0009 0.0067 0.007
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0199 0.0192
Loa Loa (eye worm) hypothetical protein 0.0009 0.0067 0.0137
Loa Loa (eye worm) hypothetical protein 0.0027 0.0288 0.0625
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0199 0.0192
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0199 0.0232
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0199 0.0165
Loa Loa (eye worm) hypothetical protein 0.0023 0.0242 0.0524
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0706 1
Echinococcus granulosus microtubule associated protein 2 0.0679 0.8562 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0156 0.195
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0199 0.0428
Schistosoma mansoni blooms syndrome DNA helicase 0.0017 0.0159 0.0186
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.006 0.0706 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.003 0.0000000024489
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0242 0.3212
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0009 0.0067 0.1167
Schistosoma mansoni hypothetical protein 0.0067 0.0796 0.093
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0199 0.0192
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.001 0.0081 0.0046
Schistosoma mansoni nuclear hormone receptor 0.0009 0.0067 0.0078
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0242 0.3091
Loa Loa (eye worm) nuclear receptor NHR-67 0.0009 0.0067 0.0137
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0018 0.0183 0.6531
Onchocerca volvulus Protein ultraspiracle homolog 0.002 0.0199 0.6023
Brugia malayi nuclear receptor RXR 0.001 0.0081 0.0102
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0009 0.0067 0.0032
Loa Loa (eye worm) hypothetical protein 0.0012 0.0106 0.0224
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0199 0.0192
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0261 1
Schistosoma mansoni intermediate filament proteins 0.0027 0.0288 0.0336
Echinococcus multilocularis alpha 1,6 mannosyl glycoprotein 0.0362 0.4539 0.452
Loa Loa (eye worm) hypothetical protein 0.0148 0.1829 0.4023
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0261 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0199 0.0364
Schistosoma mansoni thyroid hormone receptor 0.002 0.0199 0.0232
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0199 0.0364
Onchocerca volvulus 0.0027 0.0288 0.9301
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0706 0.0825
Entamoeba histolytica recQ family helicase, putative 0.0011 0.0091 0.3683
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0009 0.0067 0.007
Loa Loa (eye worm) hypothetical protein 0.0017 0.0168 0.0361
Giardia lamblia Sgs1 DNA helicase, putative 0.0009 0.0059 0.5
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0199 0.0364
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0009 0.0067 0.0037
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0242 0.0461
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0199 0.0364
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0199 0.0232
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0007 0.0035 0.118
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.006 0.0706 0.0674
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0242 0.3091
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0098 0.1189 0.2561
Entamoeba histolytica recQ family DNA helicase 0.0004 0.0005 0.0089
Loa Loa (eye worm) hypothetical protein 0.002 0.0199 0.0428
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0007 0.0038 0.0003
Brugia malayi nuclear receptor NHR-88 0.002 0.0199 0.0364
Brugia malayi nuclear hormone receptor 0.002 0.0199 0.0364
Loa Loa (eye worm) hypothetical protein 0.001 0.0081 0.0168
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0011 0.0091 0.2476
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0242 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0199 0.0364
Echinococcus multilocularis musashi 0.0027 0.0288 0.0254
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.001 0.0081 0.0054
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.006 0.0706 0.0788
Loa Loa (eye worm) hypothetical protein 0.002 0.0199 0.0428
Brugia malayi CXXC zinc finger family protein 0.0028 0.0307 0.0604
Loa Loa (eye worm) hypothetical protein 0.0098 0.1189 0.2611
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0341 0.068
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.003 0.0000000024489
Echinococcus multilocularis thyroid hormone receptor alpha 0.002 0.0199 0.0165
Loa Loa (eye worm) hypothetical protein 0.0017 0.0168 0.0361
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0199 0.0232
Loa Loa (eye worm) hypothetical protein 0.001 0.0081 0.0168
Brugia malayi hypothetical protein 0.001 0.0081 0.0102
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0007 0.0035 0.0175
Brugia malayi hypothetical protein 0.001 0.0081 0.0102
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0017 0.0168 0.1985
Loa Loa (eye worm) hypothetical protein 0.002 0.0199 0.0428
Schistosoma mansoni nuclear hormone receptor 0.0009 0.0067 0.0078
Brugia malayi hypothetical protein 0.0025 0.0261 0.0502

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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