Detailed information for compound 648666

Basic information

Technical information
  • TDR Targets ID: 648666
  • Name: 1-(2,4-dimethylphenoxy)-3-(4-pyridin-2-ylpipe razin-1-yl)propan-2-ol
  • MW: 341.447 | Formula: C20H27N3O2
  • H donors: 1 H acceptors: 2 LogP: 2.9 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(CN1CCN(CC1)c1ccccn1)COc1ccc(cc1C)C
  • InChi: 1S/C20H27N3O2/c1-16-6-7-19(17(2)13-16)25-15-18(24)14-22-9-11-23(12-10-22)20-5-3-4-8-21-20/h3-8,13,18,24H,9-12,14-15H2,1-2H3
  • InChiKey: MQRIKYUXHJMNBI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 1-(2,4-dimethylphenoxy)-3-[4-(2-pyridyl)piperazin-1-yl]propan-2-ol
  • 1-(2,4-dimethylphenoxy)-3-[4-(2-pyridyl)-1-piperazinyl]propan-2-ol
  • Oprea1_418095
  • Oprea1_514291

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0097 0.0065 0.0111
Brugia malayi serine/threonine-protein kinase plk-2 0.0097 0.0065 0.0111
Schistosoma mansoni lamin 0.0225 0.0236 0.0429
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0225 0.0236 0.0233
Onchocerca volvulus Serine\/threonine kinase homolog 0.0097 0.0065 0.0266
Schistosoma mansoni alpha-glucosidase 0.015 0.0135 0.0245
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0072 0.003 0.0049
Loa Loa (eye worm) hypothetical protein 0.0072 0.003 0.0053
Loa Loa (eye worm) hypothetical protein 0.0221 0.023 0.0418
Loa Loa (eye worm) hypothetical protein 0.0886 0.1126 0.2048
Trypanosoma brucei hypothetical protein, conserved 0.0073 0.0032 0.0051
Trichomonas vaginalis penicillin-binding protein, putative 0.0073 0.0032 0.0933
Onchocerca volvulus 0.0449 0.0537 0.2244
Brugia malayi cytoplasmic intermediate filament protein 0.012 0.0096 0.0168
Echinococcus multilocularis inosine 5' monophosphate dehydrogenase 2 0.4132 0.5491 0.5489
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0097 0.0065 0.0116
Loa Loa (eye worm) GMP reductase 0.1826 0.2389 0.435
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.0032 0.0933
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0072 0.003 0.0054
Echinococcus granulosus ecdysone induced protein 78C 0.0072 0.003 0.0049
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0144 0.0128 0.0227
Onchocerca volvulus 0.0073 0.0032 0.0128
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0305 0.0344 0.0621
Echinococcus granulosus lamin 0.0225 0.0236 0.0423
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0073 0.0032 0.0057
Trypanosoma cruzi polo-like protein kinase, putative 0.0097 0.0065 0.0111
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0144 0.0128 0.0227
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0072 0.003 0.0049
Loa Loa (eye worm) hypothetical protein 0.0073 0.0032 0.0056
Brugia malayi GMP reductase 0.1826 0.2389 0.4347
Echinococcus multilocularis musashi 0.0225 0.0236 0.0232
Loa Loa (eye worm) hypothetical protein 0.0072 0.003 0.0053
Loa Loa (eye worm) hypothetical protein 0.0072 0.003 0.0053
Schistosoma mansoni retinoic acid receptor RXR 0.0072 0.003 0.0054
Schistosoma mansoni RAR-like nuclear receptor 0.0072 0.003 0.0054
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0305 0.0344 0.0621
Schistosoma mansoni transcription factor LCR-F1 0.0225 0.0236 0.0429
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0072 0.003 0.0049
Schistosoma mansoni survival motor neuron protein 0.0449 0.0537 0.0977
Echinococcus granulosus lysosomal alpha glucosidase 0.0174 0.0168 0.0299
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0072 0.003 0.0053
Trypanosoma cruzi GMP reductase 0.4132 0.5491 1
Schistosoma mansoni inosine-5-monophosphate dehydrogenase 0.4132 0.5491 1
Brugia malayi steroid hormone receptor 0.0072 0.003 0.0049
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0072 0.003 0.0049
Echinococcus multilocularis lysosomal alpha glucosidase 0.0174 0.0168 0.0164
Echinococcus granulosus tumor protein p63 0.0342 0.0394 0.0712
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0072 0.003 0.0049
Brugia malayi latrophilin 2 splice variant baaae 0.0076 0.0035 0.0058
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0072 0.003 0.0053
Loa Loa (eye worm) hypothetical protein 0.0072 0.003 0.0053
Onchocerca volvulus 0.0073 0.0032 0.0128
Loa Loa (eye worm) hypothetical protein 0.022 0.0229 0.0416
Leishmania major hypothetical protein, conserved 0.0073 0.0032 0.0051
Brugia malayi hypothetical protein 0.0225 0.0236 0.0424
Mycobacterium tuberculosis Conserved hypothetical protein 0.0161 0.015 0.0217
Loa Loa (eye worm) hypothetical protein 0.0886 0.1126 0.2048
Onchocerca volvulus 0.0225 0.0236 0.0983
Onchocerca volvulus Bile acid receptor homolog 0.0072 0.003 0.0122
Trypanosoma cruzi polo-like protein kinase, putative 0.0097 0.0065 0.0111
Onchocerca volvulus 0.0101 0.0069 0.0284
Brugia malayi hypothetical protein 0.0886 0.1126 0.2045
Schistosoma mansoni hypothetical protein 0.0076 0.0035 0.0063
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0144 0.0128 0.0227
Onchocerca volvulus 0.0073 0.0032 0.0128
Trypanosoma cruzi hypothetical protein, conserved 0.0073 0.0032 0.0051
Schistosoma mansoni hypothetical protein 0.0225 0.0236 0.0429
Brugia malayi hypothetical protein 0.2199 0.2891 0.5262
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0073 0.0032 0.0051
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0072 0.003 0.0053
Brugia malayi Intermediate filament tail domain containing protein 0.0225 0.0236 0.0423
Leishmania major mitochondrial DNA polymerase beta 0.0305 0.0344 0.0621
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0072 0.003 0.0027
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0072 0.003 0.0122
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.012 0.0096 0.0172
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0072 0.003 0.0053
Loa Loa (eye worm) hypothetical protein 0.0073 0.0032 0.0056
Loa Loa (eye worm) hypothetical protein 0.0108 0.008 0.0143
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0065 0.2022
Leishmania major inosine-5-monophosphate dehydrogenase 0.4132 0.5491 1
Schistosoma mansoni alpha-glucosidase 0.015 0.0135 0.0245
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0065 0.2022
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.4132 0.5491 1
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0072 0.003 0.0049
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0072 0.003 0.0049
Echinococcus multilocularis FTZ F1 alpha 0.0072 0.003 0.0027
Echinococcus granulosus geminin 0.0184 0.0181 0.0323
Schistosoma mansoni microtubule-associated protein tau 0.0707 0.0885 0.1611
Trichomonas vaginalis esterase, putative 0.0073 0.0032 0.0933
Entamoeba histolytica hypothetical protein 0.0225 0.0236 1
Brugia malayi MH2 domain containing protein 0.0127 0.0105 0.0185
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0052 0.0004 0.0001
Entamoeba histolytica hypothetical protein 0.0225 0.0236 1
Loa Loa (eye worm) nuclear hormone receptor 0.0216 0.0224 0.0406
Toxoplasma gondii IMP dehydrogenas 0.4132 0.5491 1
Echinococcus multilocularis ecdysone induced protein 78C 0.0072 0.003 0.0027
Entamoeba histolytica hypothetical protein 0.0225 0.0236 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0072 0.003 0.0049
Loa Loa (eye worm) glutaminase 0.0276 0.0305 0.0554
Brugia malayi nuclear receptor NHR-88 0.0072 0.003 0.0049
Loa Loa (eye worm) MH2 domain-containing protein 0.0127 0.0105 0.0189
Brugia malayi inosine-5'-monophosphate dehydrogenase 0.1826 0.2389 0.4347
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0174 0.0168 0.0303
Schistosoma mansoni serine/threonine protein kinase 0.0097 0.0065 0.0117
Schistosoma mansoni hypothetical protein 0.0184 0.0181 0.0328
Echinococcus granulosus inosine 5' monophosphate dehydrogenase 2 0.4132 0.5491 1
Echinococcus granulosus survival motor neuron protein 1 0.2199 0.2891 0.5262
Loa Loa (eye worm) hypothetical protein 0.0225 0.0236 0.0428
Schistosoma mansoni cellular tumor antigen P53 0.005 0.0001 0.0001
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0305 0.0344 0.0621
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0072 0.003 0.0054
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0072 0.003 0.0027
Echinococcus multilocularis thyroid hormone receptor alpha 0.0072 0.003 0.0027
Loa Loa (eye worm) hypothetical protein 0.0073 0.0032 0.0056
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0072 0.003 0.0049
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0072 0.003 0.0027
Loa Loa (eye worm) transcription factor SMAD2 0.0127 0.0105 0.0189
Loa Loa (eye worm) hypothetical protein 0.0076 0.0035 0.0062
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0072 0.003 0.0053
Brugia malayi nuclear hormone receptor 0.0072 0.003 0.0049
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.0032 0.0933
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.1826 0.2389 0.4318
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0225 0.0236 0.0424
Brugia malayi beta-lactamase family protein 0.0073 0.0032 0.0051
Schistosoma mansoni glutaminase 0.0276 0.0305 0.0555
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0693 0.0865 0.1574
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) 0.4132 0.5491 1
Loa Loa (eye worm) intermediate filament protein 0.0225 0.0236 0.0428
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB3 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.2307 0.3036 0.5503
Onchocerca volvulus Putative GMP reductase 0.1826 0.2389 1
Onchocerca volvulus 0.0225 0.0236 0.0983
Onchocerca volvulus Huntingtin homolog 0.0886 0.1126 0.4709
Brugia malayi follicle stimulating hormone receptor 0.0693 0.0865 0.157
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.4132 0.5491 1
Brugia malayi Glycosyl hydrolases family 31 protein 0.0174 0.0168 0.0299
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0072 0.003 0.0049
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0254 0.0275 0.0271
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0072 0.003 0.0027
Schistosoma mansoni serine/threonine protein kinase 0.0052 0.0004 0.0006
Echinococcus multilocularis lysosomal alpha glucosidase 0.0174 0.0168 0.0164
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.4132 0.5491 1
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0052 0.0004 0.0007
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0065 0.2022
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0108 0.008 0.0076
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0073 0.0032 0.0056
Trypanosoma brucei inosine-5'-monophosphate dehydrogenase 0.4132 0.5491 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0072 0.003 0.0053
Mycobacterium ulcerans glutaminase 0.0276 0.0305 0.0501
Trichomonas vaginalis penicillin-binding protein, putative 0.0073 0.0032 0.0933
Wolbachia endosymbiont of Brugia malayi IMP dehydrogenase 0.4132 0.5491 0.5
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0072 0.003 0.0049
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.4132 0.5491 1
Leishmania major guanosine monophosphate reductase 0.4132 0.5491 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0111 0.0082 0.0148
Loa Loa (eye worm) hypothetical protein 0.0073 0.0032 0.0056
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0072 0.003 0.0049
Schistosoma mansoni coup transcription factor 0.0072 0.003 0.0054
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0072 0.003 0.0054
Loa Loa (eye worm) hypothetical protein 0.0072 0.003 0.0053
Brugia malayi photoreceptor-specific nuclear receptor 0.0072 0.003 0.0049
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0111 0.0082 0.0144
Echinococcus granulosus beta LACTamase domain containing family member 0.0073 0.0032 0.0051
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0065 0.2022
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0072 0.003 0.0049
Echinococcus multilocularis survival motor neuron protein 1 0.2199 0.2891 0.2888
Schistosoma mansoni nuclear hormone receptor 0.0072 0.003 0.0054
Echinococcus multilocularis tumor protein p63 0.0342 0.0394 0.0391
Echinococcus multilocularis beta LACTamase domain containing family member 0.0073 0.0032 0.0028
Toxoplasma gondii ABC1 family protein 0.0073 0.0032 0.0058
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0072 0.003 0.0049
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0072 0.003 0.0054
Loa Loa (eye worm) hypothetical protein 0.0072 0.003 0.0053
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0052 0.0004 0.0004
Schistosoma mansoni hypothetical protein 0.0184 0.0181 0.0328
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0072 0.003 0.0049
Loa Loa (eye worm) hypothetical protein 0.2199 0.2891 0.5264
Brugia malayi inosine-5'-monophosphate dehydrogenase family protein 0.4132 0.5491 1
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0065 0.2022
Schistosoma mansoni thyroid hormone receptor 0.0072 0.003 0.0054
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0072 0.003 0.0049
Loa Loa (eye worm) beta-lactamase 0.0073 0.0032 0.0056
Loa Loa (eye worm) IMP dehydrogenase 1 0.4132 0.5491 1
Brugia malayi beta-lactamase 0.0073 0.0032 0.0051
Echinococcus multilocularis lamin 0.0225 0.0236 0.0232
Plasmodium vivax inosine-5'-monophosphate dehydrogenase, putative 0.4132 0.5491 1
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0449 0.0537 0.0972
Echinococcus granulosus intermediate filament protein 0.0225 0.0236 0.0423
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0097 0.0065 0.0061
Brugia malayi beta-lactamase family protein 0.0073 0.0032 0.0051
Plasmodium falciparum inosine-5'-monophosphate dehydrogenase 0.4132 0.5491 0.5
Trichomonas vaginalis glutaminase, putative 0.0276 0.0305 1
Loa Loa (eye worm) hypothetical protein 0.0072 0.003 0.0053
Echinococcus multilocularis microtubule associated protein 2 0.0707 0.0885 0.0882
Trypanosoma cruzi GMP reductase 0.4132 0.5491 1
Mycobacterium ulcerans inosine 5'-monophosphate dehydrogenase 0.4132 0.5491 1
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0097 0.0065 0.0111
Onchocerca volvulus Huntingtin homolog 0.0886 0.1126 0.4709
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0072 0.003 0.0054
Schistosoma mansoni intermediate filament proteins 0.0225 0.0236 0.0429
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0254 0.0275 0.0495
Echinococcus granulosus FTZ F1 alpha 0.0072 0.003 0.0049
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0466 0.056 0.0967
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.0032 0.0933
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0073 0.0032 0.0057
Trypanosoma brucei GMP reductase 0.4132 0.5491 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.0072 0.003 0.0054
Schistosoma mansoni hypothetical protein 0.0449 0.0537 0.0977
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena 0.2307 0.3036 0.5503
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0225 0.0236 0.0428
Echinococcus granulosus lamin dm0 0.0225 0.0236 0.0423
Loa Loa (eye worm) hypothetical protein 0.0104 0.0074 0.0133
Loa Loa (eye worm) glutaminase 2 0.0276 0.0305 0.0554
Brugia malayi Steroid receptor seven-up type 2 0.0254 0.0275 0.0495
Brugia malayi glutaminase DH11.1 0.0276 0.0305 0.055
Schistosoma mansoni thyroid hormone receptor 0.0072 0.003 0.0054
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0072 0.003 0.0049
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.4132 0.5491 1
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0065 0.2022
Giardia lamblia Kinase, PLK 0.0097 0.0065 1
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0072 0.003 0.0054
Trypanosoma brucei polo-like protein kinase 0.0097 0.0065 0.0111
Loa Loa (eye worm) hypothetical protein 0.0073 0.0032 0.0056
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0072 0.003 0.0049
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0108 0.008 0.0138
Mycobacterium ulcerans hypothetical protein 0.0161 0.015 0.0217
Mycobacterium leprae PROBABLE INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE GUAB1(IMP DEHYDROGENASE) (IMPDH) (IMPD) 0.1826 0.2389 0.4318
Loa Loa (eye worm) hypothetical protein 0.0104 0.0074 0.0133
Trypanosoma cruzi hypothetical protein, conserved 0.0073 0.0032 0.0051
Echinococcus multilocularis lamin dm0 0.0225 0.0236 0.0232
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0072 0.003 0.0053
Brugia malayi Nuclear hormone receptor-like 1 0.0072 0.003 0.0049
Entamoeba histolytica hypothetical protein 0.0225 0.0236 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0072 0.003 0.0049
Onchocerca volvulus 0.0072 0.003 0.0122
Brugia malayi ecdysteroid receptor 0.0072 0.003 0.0049
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0065 0.2022
Echinococcus granulosus microtubule associated protein 2 0.0707 0.0885 0.1606
Schistosoma mansoni lamin 0.0225 0.0236 0.0429
Onchocerca volvulus Protein ultraspiracle homolog 0.0072 0.003 0.0122
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0072 0.003 0.0027
Echinococcus multilocularis geminin 0.0184 0.0181 0.0177
Loa Loa (eye worm) hypothetical protein 0.0072 0.003 0.0053
Loa Loa (eye worm) steroid hormone receptor 0.0072 0.003 0.0053
Brugia malayi Calcitonin receptor-like protein seb-1 0.0111 0.0082 0.0144
Brugia malayi intermediate filament protein 0.0225 0.0236 0.0423
Loa Loa (eye worm) hypothetical protein 0.0073 0.0032 0.0056
Brugia malayi inosine-5'-monophosphate dehydrogenase 0.1826 0.2389 0.4347
Loa Loa (eye worm) hypothetical protein 0.0111 0.0082 0.0148

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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