Detailed information for compound 650828

Basic information

Technical information
  • TDR Targets ID: 650828
  • Name: ethyl 3-amino-1-(3-hydroxyphenyl)-1H-benzo[f] chromene-2-carboxylate
  • MW: 361.391 | Formula: C22H19NO4
  • H donors: 2 H acceptors: 2 LogP: 4.69 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)C1=C(N)Oc2c(C1c1cccc(c1)O)c1ccccc1cc2
  • InChi: 1S/C22H19NO4/c1-2-26-22(25)20-18(14-7-5-8-15(24)12-14)19-16-9-4-3-6-13(16)10-11-17(19)27-21(20)23/h3-12,18,24H,2,23H2,1H3
  • InChiKey: QASYRDUOQQQSAO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 3-amino-1-(3-hydroxyphenyl)-1H-benzo[f]chromene-2-carboxylic acid ethyl ester
  • ChemDiv1_021909
  • Oprea1_752234
  • 3-Amino-1-(3-hydroxy-phenyl)-1H-benzo[f]chromene-2-carboxylic acid ethyl ester
  • BAS 01842361
  • Oprea1_233901
  • STOCK1S-75942

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0049 0.0704 0.1474
Schistosoma mansoni serine/threonine protein kinase 0.0049 0.0702 0.0941
Trypanosoma cruzi DNA polymerase eta, putative 0.0022 0.0145 0.1937
Loa Loa (eye worm) hypothetical protein 0.002 0.0107 0.0225
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0025 0.0217 0.0245
Schistosoma mansoni loxhd1 0.002 0.0107 0.0087
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0027 0.0247 0.0888
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0036 0.0433 0.0555
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0022 0.0145 0.0181
Loa Loa (eye worm) hypothetical protein 0.0036 0.0433 0.0906
Brugia malayi beta-lactamase family protein 0.0036 0.0439 0.0919
Mycobacterium leprae Probable lipase LipE 0.0036 0.0439 0.9773
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0458 0.0756
Schistosoma mansoni intermediate filament proteins 0.0027 0.0255 0.0299
Leishmania major lysyl-tRNA synthetase, putative 0.0027 0.0247 0.0888
Onchocerca volvulus 0.0286 0.548 1
Trichomonas vaginalis glucose transporter, putative 0.0037 0.0458 0.0756
Schistosoma mansoni phd/f-box containing protein 0.0025 0.0217 0.0245
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0156 0.2849 0.4023
Trichomonas vaginalis conserved hypothetical protein 0.012 0.213 0.3834
Schistosoma mansoni rab6-interacting 0.002 0.0107 0.0087
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0037 0.0446 0.0918
Brugia malayi Calcitonin receptor-like protein seb-1 0.0156 0.2862 0.5988
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0025 0.0217 0.0245
Trichomonas vaginalis sugar transporter, putative 0.0037 0.0458 0.0756
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0041 0.0532 0.6954
Plasmodium vivax CDK-related protein kinase 6, putative 0.051 1 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0047 0.0097
Brugia malayi Major Facilitator Superfamily protein 0.0017 0.0047 0.0097
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.0433 0.0555
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0145 0.1965
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0036 0.0433 0.0906
Brugia malayi Pre-SET motif family protein 0.0251 0.4779 1
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0439 0.0904
Leishmania major hypothetical protein, conserved 0.0036 0.0439 0.1741
Loa Loa (eye worm) hypothetical protein 0.0017 0.0047 0.0097
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0346 0.0431
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0041 0.0532 1
Plasmodium falciparum mitogen-activated protein kinase 2 0.0194 0.3628 0.3598
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0032 0.0346 0.0301
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0996 0.1363
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0439 0.0904
Schistosoma mansoni jumonji/arid domain-containing protein 0.0095 0.1623 0.2263
Onchocerca volvulus 0.0027 0.0255 0.0384
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.012 0.213 0.299
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0036 0.0433 0.955
Schistosoma mansoni protein phosphatase 2C 0.0025 0.0217 0.0245
Brugia malayi lysyl-tRNA synthetase 0.0027 0.0247 0.0516
Schistosoma mansoni inositol monophosphatase 0.0041 0.0532 0.0697
Echinococcus multilocularis General substrate transporter 0.0103 0.1789 0.2501
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0032 0.0346 0.0431
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0439 0.0564
Echinococcus multilocularis Polycystic kidney disease protein 0.002 0.0107 0.0087
Trichomonas vaginalis DNA polymerase eta, putative 0.0022 0.0145 0.0181
Plasmodium falciparum calcium-dependent protein kinase 4 0.0049 0.0703 0.0659
Mycobacterium ulcerans DNA polymerase IV 0.0022 0.0145 0.0435
Loa Loa (eye worm) hypothetical protein 0.0027 0.0245 0.0513
Trypanosoma brucei THT1 - hexose transporter, putative 0.0037 0.0458 0.6475
Toxoplasma gondii protein kinase, putative 0.034 0.656 1
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0032 0.0346 0.069
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0042 0.0553 0.2248
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0042 0.0553 0.0778
Schistosoma mansoni ap endonuclease 0.0039 0.0493 0.0641
Trypanosoma brucei unspecified product 0.0022 0.0145 0.1965
Trypanosoma cruzi hexose transporter, putative 0.0037 0.0458 0.8107
Echinococcus granulosus phd:f box containing protein 0.0025 0.0217 0.0245
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0458 0.0756
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0255 0.0534
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.03 0.0363
Chlamydia trachomatis lysine--tRNA ligase 0.0027 0.0247 0.5
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0156 0.2862 0.5988
Echinococcus multilocularis dna polymerase kappa 0.0022 0.0145 0.0141
Onchocerca volvulus 0.0049 0.0704 0.121
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0145 0.1965
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0145 0.1965
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0156 0.2849 0.4023
Trichomonas vaginalis sugar transporter, putative 0.0037 0.0458 0.0756
Toxoplasma gondii ABC1 family protein 0.0036 0.0439 0.0603
Entamoeba histolytica hypothetical protein 0.0027 0.0247 0.1831
Loa Loa (eye worm) RNA binding protein 0.0064 0.0996 0.2085
Toxoplasma gondii exonuclease III APE 0.0039 0.0493 0.0685
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0039 0.0493 0.0641
Leishmania major DNA polymerase kappa, putative 0.0022 0.0145 0.0435
Echinococcus granulosus lysine specific demethylase 5A 0.0095 0.1623 0.2263
Echinococcus multilocularis jumonji domain containing protein 0.0041 0.0532 0.0697
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0439 0.6212
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0439 0.0723
Loa Loa (eye worm) inositol-1 0.0041 0.0532 0.1114
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0439 0.0904
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0025 0.0217 0.3361
Schistosoma mansoni hypothetical protein 0.0049 0.0704 0.0944
Echinococcus granulosus tar DNA binding protein 0.0064 0.0996 0.1363
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0996 0.1363
Trypanosoma brucei sugar transporter, putative 0.0017 0.0047 0.0549
Trypanosoma brucei THT1 - hexose transporter, putative 0.0037 0.0458 0.6475
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0996 0.1363
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0023 0.0165 0.0273
Trypanosoma brucei glucose transporter, putative 0.0037 0.0458 0.6475
Onchocerca volvulus 0.002 0.0107 0.0112
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0039 0.0493 0.6247
Brugia malayi Inositol-1 0.0041 0.0532 0.1114
Echinococcus granulosus dna polymerase eta 0.0022 0.0145 0.0141
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0049 0.0702 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0145 0.1965
Schistosoma mansoni glucose transport protein 0.012 0.213 0.299
Brugia malayi TAR-binding protein 0.0064 0.0996 0.2085
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0049 0.0703 0.1007
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0025 0.0217 0.0245
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0439 0.0564
Schistosoma mansoni jumonji domain containing protein 0.0025 0.0217 0.0245
Brugia malayi ImpB/MucB/SamB family protein 0.0022 0.0145 0.0303
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0049 0.0702 0.0941
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0145 0.1937
Plasmodium falciparum lysine--tRNA ligase 0.0027 0.0247 0.0201
Echinococcus granulosus lamin dm0 0.0027 0.0255 0.0299
Toxoplasma gondii isocitrate dehydrogenase 0.0032 0.0346 0.0461
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.0493 0.0448
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0049 0.0703 0.1007
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0036 0.0433 0.0906
Plasmodium vivax lysine--tRNA ligase, putative 0.0027 0.0247 0.0201
Schistosoma mansoni lamin 0.0027 0.0255 0.0299
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0039 0.0493 0.1027
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.012 0.213 0.299
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0049 0.0704 0.1474
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0039 0.0493 0.1031
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0439 0.0564
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0041 0.0532 0.2154
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0129 0.2302 0.3237
Echinococcus granulosus histone lysine methyltransferase setb 0.0036 0.0433 0.0555
Mycobacterium ulcerans aldehyde dehydrogenase 0.0129 0.2302 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0047 0.0097
Echinococcus multilocularis calcium dependent protein kinase 0.0047 0.0651 0.0868
Schistosoma mansoni inositol monophosphatase 0.0041 0.0532 0.0697
Brugia malayi Isocitrate dehydrogenase 0.0032 0.0346 0.0725
Brugia malayi jmjC domain containing protein 0.0156 0.2849 0.5962
Trichomonas vaginalis set domain proteins, putative 0.0286 0.548 1
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0039 0.0493 0.1979
Echinococcus multilocularis geminin 0.0362 0.7013 1
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0119 0.2109 0.296
Onchocerca volvulus 0.0036 0.0439 0.0723
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0156 0.2862 0.5988
Brugia malayi RNA recognition motif domain containing protein 0.0064 0.0996 0.2085
Treponema pallidum exodeoxyribonuclease (exoA) 0.0039 0.0493 0.5
Brugia malayi beta-lactamase 0.0036 0.0439 0.0919
Plasmodium falciparum calcium-dependent protein kinase 5 0.0049 0.0703 0.0659
Echinococcus granulosus intermediate filament protein 0.0027 0.0255 0.0299
Echinococcus granulosus lysyl tRNA synthetase 0.0027 0.0247 0.0287
Echinococcus multilocularis muscleblind protein 1 0.0166 0.3049 0.4309
Schistosoma mansoni lysyl-tRNA synthetase 0.0027 0.0247 0.0287
Trypanosoma brucei glucose transporter 2A 0.0037 0.0458 0.6475
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0036 0.0433 0.0555
Schistosoma mansoni lysyl-tRNA synthetase 0.0027 0.0247 0.0287
Trypanosoma brucei glucose transporter, putative 0.0037 0.0458 0.6475
Leishmania major hypothetical protein, conserved 0.0025 0.0217 0.0756
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0049 0.0704 0.0944
Schistosoma mansoni polycystin 1-related 0.002 0.0107 0.0087
Plasmodium vivax proline--tRNA ligase, putative 0.0042 0.0553 0.0509
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0439 0.0904
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0037 0.0446 1
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0049 0.0702 0.0941
Echinococcus multilocularis dna polymerase eta 0.0022 0.0145 0.0141
Echinococcus multilocularis jumonji domain containing 1A 0.0025 0.0217 0.0245
Brugia malayi jmjC domain containing protein 0.0025 0.0217 0.0454
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0041 0.0532 0.0894
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0036 0.0433 0.0711
Echinococcus granulosus RUN 0.002 0.0107 0.0087
Schistosoma mansoni hypothetical protein 0.0107 0.1863 0.2608
Plasmodium falciparum phd finger protein, putative 0.0029 0.03 0.0254
Loa Loa (eye worm) hypothetical protein 0.0017 0.0047 0.0097
Toxoplasma gondii isocitrate dehydrogenase 0.0032 0.0346 0.0461
Brugia malayi Sugar transporter family protein 0.0017 0.0047 0.0097
Loa Loa (eye worm) hypothetical protein 0.0027 0.0255 0.0534
Schistosoma mansoni hypothetical protein 0.0362 0.7013 1
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0027 0.0247 0.0888
Schistosoma mansoni jumonji/arid domain-containing protein 0.0095 0.1623 0.2263
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.03 0.0363
Onchocerca volvulus 0.002 0.0107 0.0112
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0145 0.1965
Giardia lamblia DINP protein human, muc B family 0.0022 0.0145 0.22
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0144 0.2616 0.5475
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0022 0.0145 0.0303
Entamoeba histolytica protein kinase, putative 0.0049 0.0702 1
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0036 0.0433 0.0555
Brugia malayi hypothetical protein 0.002 0.0107 0.0225
Brugia malayi major facilitator superfamily protein 0.0017 0.0047 0.0097
Schistosoma mansoni ap endonuclease 0.0039 0.0493 0.0641
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0439 0.0904
Brugia malayi hypothetical protein 0.002 0.0107 0.0225
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0433 0.0555
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.03 0.0389
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0145 0.1965
Trypanosoma cruzi hexose transporter 0.0037 0.0458 0.8107
Brugia malayi Doublecortin family protein 0.002 0.0107 0.0225
Brugia malayi latrophilin 2 splice variant baaae 0.0107 0.1863 0.3899
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0107 0.0087
Onchocerca volvulus 0.0036 0.0433 0.0712
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0027 0.0247 0.3437
Echinococcus granulosus muscleblind protein 0.0166 0.3049 0.4309
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0255 0.0534
Plasmodium falciparum calcium-dependent protein kinase 2 0.0049 0.0703 0.0659
Giardia lamblia PHD finger protein 15 0.0029 0.03 0.5672
Echinococcus granulosus geminin 0.0362 0.7013 1
Echinococcus multilocularis lysine specific demethylase 5A 0.0095 0.1623 0.2263
Mycobacterium ulcerans aldehyde dehydrogenase 0.0129 0.2302 1
Brugia malayi MH2 domain containing protein 0.0144 0.2616 0.5474
Trypanosoma brucei glucose transporter, putative 0.0037 0.0458 0.6475
Loa Loa (eye worm) hypothetical protein 0.0049 0.0704 0.1473
Trichomonas vaginalis esterase, putative 0.0036 0.0439 0.0723
Echinococcus multilocularis lysine specific demethylase 6a 0.0025 0.0217 0.0245
Schistosoma mansoni lipoxygenase 0.0119 0.2109 0.296
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0532 0.958
Loa Loa (eye worm) hypothetical protein 0.0017 0.0047 0.0097
Loa Loa (eye worm) hypothetical protein 0.0027 0.0247 0.0516
Brugia malayi RNA binding protein 0.0064 0.0996 0.2085
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0025 0.0217 0.3006
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0439 0.0723
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0144 0.2616 0.3689
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0439 0.0904
Trypanosoma brucei glucose transporter, putative 0.0037 0.0458 0.6475
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0027 0.0247 0.0369
Echinococcus multilocularis inositol monophosphatase 1 0.0041 0.0532 0.0697
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0145 0.1937
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0042 0.0553 1
Loa Loa (eye worm) doublecortin family protein 0.002 0.0107 0.0225
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0144 0.2616 0.3689
Loa Loa (eye worm) sugar transporter 0.012 0.213 0.4457
Brugia malayi Major Facilitator Superfamily protein 0.0017 0.0047 0.0097
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0439 0.0395
Echinococcus multilocularis GPCR, family 2 0.0049 0.0704 0.0944
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0144 0.2616 0.3689
Giardia lamblia Lysyl-tRNA synthetase 0.0027 0.0247 0.4487
Trypanosoma brucei DNA polymerase eta, putative 0.0022 0.0145 0.1965
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0049 0.0704 0.0944
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0049 0.0702 0.0941
Loa Loa (eye worm) hypothetical protein 0.0017 0.0047 0.0097
Loa Loa (eye worm) hypothetical protein 0.0029 0.03 0.0627
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0346 0.133
Brugia malayi intermediate filament protein 0.0027 0.0255 0.0534
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0145 0.1965
Loa Loa (eye worm) hypothetical protein 0.0017 0.0047 0.0097
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0049 0.0702 0.0941
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0439 0.0723
Onchocerca volvulus 0.0036 0.0439 0.0723
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0049 0.0702 0.1469
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.03 0.0363
Loa Loa (eye worm) major facilitator superfamily transporter 0.0017 0.0047 0.0097
Giardia lamblia Prolyl-tRNA synthetase 0.0036 0.0433 0.8659
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.2616 0.5474
Trypanosoma brucei glucose transporter, putative 0.0037 0.0458 0.6475
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.03 0.0389
Brugia malayi beta-lactamase family protein 0.0036 0.0439 0.0919
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0049 0.0703 0.0659
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0144 0.2616 0.3689
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.0493 0.0448
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0039 0.0493 0.8803
Brugia malayi major facilitator superfamily protein 0.0017 0.0047 0.0097
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0036 0.0433 0.0555
Onchocerca volvulus 0.0036 0.0439 0.0723
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0145 0.1965
Plasmodium vivax JmjC domain containing protein 0.0025 0.0217 0.0171
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0049 0.0703 0.1007
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.012 0.213 0.299
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.012 0.213 0.299
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0039 0.0493 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0145 0.1965
Trypanosoma brucei glucose transporter, putative 0.0037 0.0458 0.6475
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0532 0.958
Echinococcus granulosus peregrin 0.0029 0.03 0.0363
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0532 0.2154
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0107 0.0087
Loa Loa (eye worm) hypothetical protein 0.0036 0.0433 0.0906
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0049 0.0702 0.0941
Loa Loa (eye worm) hypothetical protein 0.0049 0.0702 0.1469
Trypanosoma cruzi hexose transporter, putative 0.0037 0.0458 0.8107
Brugia malayi jmjC domain containing protein 0.0095 0.1623 0.3396
Schistosoma mansoni jumonji domain containing protein 0.0136 0.245 0.3449
Toxoplasma gondii lysine-tRNA ligase 0.0027 0.0247 0.0307
Loa Loa (eye worm) hypothetical protein 0.0156 0.2862 0.5988
Brugia malayi exodeoxyribonuclease III family protein 0.0039 0.0493 0.1031
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0129 0.2302 0.3237
Schistosoma mansoni protein kinase 0.0049 0.0702 0.0941
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0032 0.0346 0.5917
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.012 0.213 0.299
Brugia malayi ImpB/MucB/SamB family protein 0.0022 0.0145 0.0303
Echinococcus granulosus inositol monophosphatase 1 0.0041 0.0532 0.0697
Brugia malayi Sugar transporter family protein 0.012 0.213 0.4457
Mycobacterium ulcerans beta-lactamase 0.0036 0.0439 0.1741
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0015 0.0004 0.0009
Plasmodium vivax multidomain scavenger receptor, putative 0.002 0.0107 0.0061
Brugia malayi Pre-SET motif family protein 0.0036 0.0433 0.0907
Loa Loa (eye worm) hypothetical protein 0.0025 0.0217 0.0454
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0433 0.0555
Brugia malayi hypothetical protein 0.0017 0.0047 0.0097
Trypanosoma brucei glucose transporter, putative 0.0037 0.0458 0.6475
Loa Loa (eye worm) beta-lactamase 0.0036 0.0439 0.0919
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0439 0.1741
Leishmania major protein kinase, putative 0.0049 0.0702 0.2906
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0041 0.0532 0.0894
Plasmodium falciparum LCCL domain-containing protein 0.002 0.0107 0.0061
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0439 0.7746
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0107 0.0087
Loa Loa (eye worm) hypothetical protein 0.0036 0.0439 0.0919
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0129 0.2302 0.5189
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0439 0.7746
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0025 0.0217 0.0262
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0346 0.4875
Schistosoma mansoni DNA polymerase eta 0.0022 0.0145 0.0141
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0255 0.0534
Schistosoma mansoni protein kinase 0.0049 0.0702 0.0941
Loa Loa (eye worm) latrophilin receptor protein 2 0.0049 0.0704 0.1474
Mycobacterium tuberculosis Conserved hypothetical protein 0.0022 0.0145 0.0226
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0049 0.0702 0.1469
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0346 0.5917
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0407 0.0517
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0022 0.0145 0.0226
Mycobacterium ulcerans lipase LipD 0.0036 0.0439 0.1741
Echinococcus granulosus GPCR family 2 0.0049 0.0704 0.0944
Leishmania major glucose transporter, lmgt1 0.0037 0.0458 0.1822
Schistosoma mansoni protein kinase 0.0049 0.0702 0.0941
Brugia malayi Latrophilin receptor protein 2 0.0049 0.0704 0.1474
Brugia malayi jmjC domain containing protein 0.0025 0.0217 0.0454
Loa Loa (eye worm) hypothetical protein 0.0017 0.0047 0.0097
Brugia malayi Major Facilitator Superfamily protein 0.0017 0.0047 0.0097
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0996 0.1363
Trichomonas vaginalis inositol monophosphatase, putative 0.0041 0.0532 0.0894
Loa Loa (eye worm) jmjC domain-containing protein 0.0025 0.0217 0.0454
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0439 0.0919
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0145 0.1937
Brugia malayi Cam kinase protein 1 0.0049 0.0702 0.1469
Loa Loa (eye worm) jmjC domain-containing protein 0.0025 0.0217 0.0454
Loa Loa (eye worm) hypothetical protein 0.0017 0.0047 0.0097
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0049 0.0702 0.0941
Mycobacterium tuberculosis Conserved protein 0.0036 0.0439 0.0904
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0039 0.0493 0.6985
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0145 0.1965
Leishmania major DNA polymerase eta, putative 0.0022 0.0145 0.0435
Plasmodium falciparum calcium-dependent protein kinase 3 0.0049 0.0703 0.0659
Loa Loa (eye worm) hypothetical protein 0.002 0.0107 0.0225
Trypanosoma cruzi hexose transporter, putative 0.0037 0.0458 0.8107
Plasmodium falciparum calcium-dependent protein kinase 1 0.0049 0.0703 0.0659
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0039 0.0493 0.1979
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0439 0.1741
Loa Loa (eye worm) hypothetical protein 0.0017 0.0047 0.0097
Plasmodium falciparum proline--tRNA ligase 0.0042 0.0553 0.0509
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0194 0.3628 0.5499
Schistosoma mansoni hypothetical protein 0.002 0.0107 0.0087
Schistosoma mansoni lipoxygenase 0.0083 0.1386 0.1922
Loa Loa (eye worm) jmjC domain-containing protein 0.0095 0.1623 0.3396
Echinococcus granulosus JmjC domain containing protein 4 0.0025 0.0217 0.0245
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0433 0.0555
Loa Loa (eye worm) hypothetical protein 0.0036 0.0439 0.0919
Loa Loa (eye worm) hypothetical protein 0.0025 0.0217 0.0454
Schistosoma mansoni hypothetical protein 0.012 0.213 0.299
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0032 0.0346 0.0431
Onchocerca volvulus Alhambra homolog 0.0029 0.03 0.0466
Trichomonas vaginalis CAMK family protein kinase 0.0049 0.0702 0.1206
Loa Loa (eye worm) hypothetical protein 0.0036 0.0439 0.0919
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0532 0.7553
Mycobacterium ulcerans aldehyde dehydrogenase 0.0129 0.2302 1
Brugia malayi Sugar transporter family protein 0.0017 0.0047 0.0097
Leishmania major glucose transporter, lmgt3 0.0037 0.0458 0.1822
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.0493 0.0821
Loa Loa (eye worm) major facilitator superfamily transporter 0.0017 0.0047 0.0097
Echinococcus granulosus jumonji domain containing 1A 0.0025 0.0217 0.0245
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0049 0.0703 0.0659
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0145 0.1965
Loa Loa (eye worm) hypothetical protein 0.0017 0.0047 0.0097
Echinococcus granulosus dna polymerase kappa 0.0022 0.0145 0.0141
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0439 0.0919
Loa Loa (eye worm) hypothetical protein 0.0036 0.0439 0.0919
Plasmodium vivax hypothetical protein, conserved 0.0029 0.03 0.0254
Echinococcus multilocularis lamin dm0 0.0027 0.0255 0.0299
Brugia malayi isocitrate dehydrogenase 0.0032 0.0346 0.0725
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.2616 0.5474
Schistosoma mansoni glucose transport protein 0.012 0.213 0.299
Echinococcus granulosus tumor protein p63 0.0338 0.6527 0.9301
Brugia malayi Muscleblind-like protein 0.0166 0.3049 0.6379
Trypanosoma cruzi hexose transporter, putative 0.002 0.0117 0.1383
Loa Loa (eye worm) isocitrate dehydrogenase 0.0032 0.0346 0.0725
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0144 0.2616 0.3689
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0039 0.0493 0.0641
Loa Loa (eye worm) hypothetical protein 0.0036 0.0439 0.0919
Trichomonas vaginalis glucose transporter, putative 0.0037 0.0458 0.0756
Trichomonas vaginalis sugar transporter, putative 0.0037 0.0458 0.0756
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.03 0.0627
Echinococcus multilocularis tumor protein p63 0.0338 0.6527 0.9301
Schistosoma mansoni hypothetical protein 0.0362 0.7013 1
Toxoplasma gondii aldehyde dehydrogenase 0.0129 0.2302 0.3462
Mycobacterium ulcerans DNA polymerase IV 0.0022 0.0145 0.0435
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0145 0.1965
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.012 0.213 0.299
Schistosoma mansoni hypothetical protein 0.0029 0.03 0.0363
Schistosoma mansoni aldehyde dehydrogenase 0.0129 0.2302 0.3237
Echinococcus granulosus Polycystic kidney disease protein 0.002 0.0107 0.0087
Echinococcus granulosus lysine specific demethylase 6a 0.0025 0.0217 0.0245
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0036 0.0433 0.0555
Echinococcus multilocularis lysyl tRNA synthetase 0.0027 0.0247 0.0287
Plasmodium vivax hexose transporter 0.012 0.213 0.2093
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0049 0.0702 0.1469
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0251 0.4779 1
Schistosoma mansoni rab6-interacting 0.002 0.0107 0.0087
Loa Loa (eye worm) sugar transporter 0.0017 0.0047 0.0097
Brugia malayi hypothetical protein 0.0017 0.0047 0.0097
Loa Loa (eye worm) hypothetical protein 0.0036 0.0433 0.0907
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0346 0.0431
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.0493 0.0821
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0145 0.1965
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0049 0.0702 0.0941
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0107 0.0087
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0144 0.2616 0.3689
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0027 0.0247 0.2909
Leishmania major glucose transporter, lmgt2 0.0037 0.0458 0.1822
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0439 0.0564
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0194 0.3628 0.3598
Loa Loa (eye worm) hypothetical protein 0.0017 0.0047 0.0097
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0145 0.1937
Schistosoma mansoni hypothetical protein 0.0049 0.0704 0.0944
Echinococcus multilocularis RUN 0.002 0.0107 0.0087
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0025 0.0217 0.0262
Loa Loa (eye worm) hypothetical protein 0.0017 0.0047 0.0097
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0049 0.0704 0.0944
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0039 0.0493 0.9189
Leishmania major glucose transporter/membrane transporter D2, putative 0.0037 0.0458 0.1822
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.012 0.213 0.299
Toxoplasma gondii facilitative glucose transporter GT1 0.012 0.213 0.3199
Brugia malayi jmjC domain containing protein 0.0025 0.0217 0.0454
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0996 0.1363
Schistosoma mansoni terminal deoxycytidyl transferase 0.0022 0.0145 0.0141
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0439 0.0723
Schistosoma mansoni phosphatidylserine receptor 0.0025 0.0217 0.0245
Echinococcus multilocularis phd:f box containing protein 0.0025 0.0217 0.0245
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0042 0.0553 0.2248
Plasmodium falciparum hexose transporter 0.012 0.213 0.2093
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0119 0.2109 0.296
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0232 0.4392 1
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0022 0.0145 0.0435
Loa Loa (eye worm) hypothetical protein 0.0029 0.0297 0.0621
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0023 0.0165 0.0273
Plasmodium vivax SET domain protein, putative 0.0036 0.0433 0.0389
Loa Loa (eye worm) hypothetical protein 0.0107 0.1863 0.3899
Loa Loa (eye worm) hypothetical protein 0.0017 0.0047 0.0097
Echinococcus granulosus calcium dependent protein kinase 0.0047 0.0651 0.0868
Trypanosoma brucei glucose transporter 1E 0.0037 0.0458 0.6475
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0025 0.0217 0.3361
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0042 0.0553 0.7859
Mycobacterium ulcerans hypothetical protein 0.0036 0.0439 0.1741
Trypanosoma brucei THT1 - hexose transporter, putative 0.0037 0.0458 0.6475
Plasmodium vivax calcium-dependent protein kinase, putative 0.0049 0.0703 0.0659
Loa Loa (eye worm) jmjC domain-containing protein 0.0025 0.0217 0.0454
Echinococcus granulosus jumonji domain containing protein 0.0041 0.0532 0.0697
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0439 0.9773
Mycobacterium tuberculosis Conserved protein 0.0036 0.0439 0.0904
Plasmodium falciparum protein kinase 7 0.034 0.656 0.6544
Schistosoma mansoni aldehyde dehydrogenase 0.0129 0.2302 0.3237
Onchocerca volvulus 0.0027 0.0255 0.0384
Brugia malayi hypothetical protein 0.0017 0.0047 0.0097
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0049 0.0703 0.0659
Echinococcus multilocularis musashi 0.0027 0.0255 0.0299
Loa Loa (eye worm) hypothetical protein 0.0036 0.0439 0.0919
Loa Loa (eye worm) hypothetical protein 0.0017 0.0047 0.0097
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0032 0.0346 0.4875
Loa Loa (eye worm) hypothetical protein 0.0166 0.3049 0.6379
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0032 0.0346 0.0301
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0439 0.0904
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.0433 0.0594
Echinococcus multilocularis muscleblind protein 0.0166 0.3049 0.4309
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0346 0.0431
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0129 0.2302 1
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0042 0.0553 1
Schistosoma mansoni hypothetical protein 0.0049 0.0704 0.0944
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0049 0.0702 0.0941
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0049 0.0704 0.0944
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0439 0.0723
Echinococcus multilocularis JmjC domain containing protein 4 0.0025 0.0217 0.0245
Schistosoma mansoni lamin 0.0027 0.0255 0.0299
Echinococcus multilocularis peregrin 0.0029 0.03 0.0363
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0041 0.0532 0.0746
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0022 0.0145 0.0141
Mycobacterium tuberculosis Conserved protein 0.0036 0.0439 0.0904
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0036 0.0433 0.0555
Brugia malayi PHD-finger family protein 0.0029 0.03 0.0627
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0144 0.2616 0.5475
Trypanosoma brucei glucose transporter, putative 0.0037 0.0458 0.6475
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0017 0.0047 0.0549
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0022 0.0145 0.0141
Echinococcus multilocularis lamin 0.0027 0.0255 0.0299
Entamoeba histolytica protein kinase, putative 0.0049 0.0702 1
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0036 0.0433 0.5173
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0039 0.0493 0.8803
Schistosoma mansoni glucose transport protein 0.012 0.213 0.299
Echinococcus multilocularis isocitrate dehydrogenase 0.0032 0.0346 0.0431
Loa Loa (eye worm) hypothetical protein 0.0166 0.3049 0.6379
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0027 0.0247 0.395
Brugia malayi jmjC domain containing protein 0.0025 0.0217 0.0454
Loa Loa (eye worm) hypothetical protein 0.0066 0.1044 0.2184
Plasmodium falciparum JmjC domain-containing protein, putative 0.0025 0.0217 0.0171
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0024 0.018 0.0246
Echinococcus multilocularis tar DNA binding protein 0.0064 0.0996 0.1363
Brugia malayi Bromodomain containing protein 0.0029 0.03 0.0627
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.0704 0.0944
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0064 0.0996 0.2085
Echinococcus granulosus lamin 0.0027 0.0255 0.0299
Loa Loa (eye worm) TAR-binding protein 0.0064 0.0996 0.2085
Loa Loa (eye worm) hypothetical protein 0.0022 0.0145 0.0303
Schistosoma mansoni hypothetical protein 0.0049 0.0704 0.0944
Echinococcus granulosus General substrate transporter 0.0103 0.1789 0.2501
Loa Loa (eye worm) jmjC domain-containing protein 0.0061 0.0932 0.1951
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.012 0.213 0.299
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0144 0.2616 0.3689
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0022 0.0145 0.0141
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0032 0.0346 0.0431

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 3.6626 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 8.1995 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.2202 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 19.9526 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.1189 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 42.2841 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 50.1187 um PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 125.8925 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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