Detailed information for compound 651497

Basic information

Technical information
  • TDR Targets ID: 651497
  • Name: ethyl 4-[[2-methyl-5-[(2-methylphenyl)carbamo yl]phenyl]sulfonylamino]benzoate
  • MW: 452.523 | Formula: C24H24N2O5S
  • H donors: 2 H acceptors: 4 LogP: 4.23 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)c1ccc(cc1)NS(=O)(=O)c1cc(ccc1C)C(=O)Nc1ccccc1C
  • InChi: 1S/C24H24N2O5S/c1-4-31-24(28)18-11-13-20(14-12-18)26-32(29,30)22-15-19(10-9-17(22)3)23(27)25-21-8-6-5-7-16(21)2/h5-15,26H,4H2,1-3H3,(H,25,27)
  • InChiKey: PHTYZHKUWWSLFR-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-[[2-methyl-5-[[(2-methylphenyl)amino]-oxomethyl]phenyl]sulfonylamino]benzoic acid ethyl ester
  • 4-[[2-methyl-5-[(2-methylphenyl)carbamoyl]phenyl]sulfonylamino]benzoic acid ethyl ester
  • 4-(2-Methyl-5-o-tolylcarbamoyl-benzenesulfonylamino)-benzoic acid ethyl ester
  • BAS 00255559
  • ZINC00888064

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium falciparum lysine--tRNA ligase 0.0023 0.0242 0.0201
Schistosoma mansoni smad1 5 8 and 0.0017 0.0115 0.0044
Schistosoma mansoni protein kinase 0.0034 0.0442 0.0373
Echinococcus multilocularis muscleblind protein 1 0.0149 0.2708 0.2655
Echinococcus multilocularis dna polymerase eta 0.0045 0.0659 0.0592
Mycobacterium ulcerans sugar transporter 0.0015 0.0071 0.2954
Schistosoma mansoni serine/threonine protein kinase 0.0521 1 1
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0023 0.0242 0.2899
Toxoplasma gondii protein kinase, putative 0.0299 0.5634 1
Echinococcus granulosus muscleblind protein 0.0149 0.2708 0.2655
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0032 0.04 0.0331
Giardia lamblia Prolyl-tRNA synthetase 0.0032 0.04 1
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0421 0.1973
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.019 0.067
Loa Loa (eye worm) hypothetical protein 0.0015 0.0071 0.0036
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0405 0.0336
Trypanosoma brucei glucose transporter, putative 0.0033 0.0421 0.614
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0021 0.019 0.2022
Loa Loa (eye worm) hypothetical protein 0.0015 0.0071 0.0036
Brugia malayi hypothetical protein 0.0236 0.4414 0.4374
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.019 0.014
Trypanosoma brucei THT1 - hexose transporter, putative 0.0033 0.0421 0.614
Trypanosoma cruzi DNA polymerase eta, putative 0.0045 0.0659 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.0405 0.037
Schistosoma mansoni smad 0.0017 0.0115 0.0044
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0242 0.0171
Trypanosoma brucei glucose transporter, putative 0.0033 0.0421 0.614
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.016 0.1904
Plasmodium falciparum hexose transporter 0.0105 0.1843 0.2087
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0037 0.0502 0.7464
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0521 1 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.04 0.0366
Echinococcus granulosus TGF beta signal transducer SmadC 0.0017 0.0115 0.0044
Echinococcus multilocularis survival motor neuron protein 1 0.0236 0.4414 0.4374
Loa Loa (eye worm) hypothetical protein 0.0045 0.0659 0.0625
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.002 0.0172 0.8497
Loa Loa (eye worm) MH2 domain-containing protein 0.0017 0.0115 0.008
Schistosoma mansoni smad1 5 8 and 0.0017 0.0115 0.0044
Schistosoma mansoni hypothetical protein 0.0032 0.0405 0.0336
Trypanosoma brucei DNA polymerase eta, putative 0.0045 0.0659 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.016 0.1904
Trypanosoma cruzi hexose transporter, putative 0.0033 0.0421 0.5949
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0105 0.1843 0.1784
Brugia malayi Calcitonin receptor-like protein seb-1 0.01 0.175 0.1691
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0037 0.0502 0.7338
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.019 0.014
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0521 1 1
Echinococcus multilocularis GPCR, family 2 0.0032 0.0405 0.0336
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0032 0.04 1
Schistosoma mansoni ap endonuclease 0.0021 0.019 0.012
Plasmodium vivax hexose transporter 0.0105 0.1843 0.2087
Loa Loa (eye worm) hypothetical protein 0.0015 0.0071 0.0036
Brugia malayi MH1 domain containing protein 0.0017 0.0115 0.0044
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0034 0.0442 0.0373
Leishmania major glucose transporter/membrane transporter D2, putative 0.0033 0.0421 0.5949
Leishmania major glucose transporter, lmgt2 0.0033 0.0421 0.5949
Trypanosoma brucei glucose transporter 1E 0.0033 0.0421 0.614
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0105 0.1843 0.1784
Loa Loa (eye worm) major facilitator superfamily transporter 0.0015 0.0071 0.0036
Toxoplasma gondii facilitative glucose transporter GT1 0.0105 0.1843 0.3184
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.01 0.1747 0.1688
Plasmodium falciparum protein kinase 7 0.0299 0.5634 0.6554
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0021 0.019 0.2022
Giardia lamblia DINP protein human, muc B family 0.0019 0.016 0.2687
Brugia malayi MH2 domain containing protein 0.0017 0.0115 0.0044
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.016 0.6608
Echinococcus multilocularis mothers against decapentaplegic 5 0.0017 0.0115 0.0044
Plasmodium vivax calcium-dependent protein kinase, putative 0.0034 0.0442 0.0437
Trypanosoma brucei glucose transporter, putative 0.0033 0.0421 0.614
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.016 0.1503
Brugia malayi Pax transcription factor protein 2 0.0252 0.4712 0.4674
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.016 0.0089
Loa Loa (eye worm) hypothetical protein 0.0015 0.0071 0.0036
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0032 0.04 0.0331
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0521 1 1
Loa Loa (eye worm) hypothetical protein 0.0149 0.2708 0.2682
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0021 0.019 0.1078
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0021 0.019 1
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0021 0.019 0.012
Brugia malayi Muscleblind-like protein 0.0149 0.2708 0.2655
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.01 0.175 0.1691
Loa Loa (eye worm) hypothetical protein 0.0015 0.0071 0.0036
Echinococcus granulosus dna polymerase eta 0.0045 0.0659 0.0592
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0405 0.0336
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.016 0.1904
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.01 0.1747 0.1718
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0034 0.0442 0.6487
Echinococcus multilocularis Smad4 0.0017 0.0115 0.0044
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0037 0.0502 0.7338
Loa Loa (eye worm) transcription factor SMAD2 0.025 0.4682 0.4663
Loa Loa (eye worm) hypothetical protein 0.0026 0.0284 0.0249
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.016 0.1503
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.019 0.067
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.016 0.1904
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0021 0.019 0.2398
Schistosoma mansoni hypothetical protein 0.0032 0.0405 0.0336
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0032 0.04 0.0331
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.016 0.1904
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0521 1 1
Trypanosoma cruzi hexose transporter 0.0033 0.0421 0.5949
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0017 0.0115 0.0044
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.016 0.0089
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0032 0.04 0.0331
Plasmodium falciparum proline--tRNA ligase 0.0037 0.0502 0.0508
Brugia malayi lysyl-tRNA synthetase 0.0023 0.0242 0.0171
Loa Loa (eye worm) hypothetical protein 0.0023 0.0242 0.0207
Entamoeba histolytica protein kinase, putative 0.0034 0.0442 1
Brugia malayi exodeoxyribonuclease III family protein 0.0021 0.019 0.012
Echinococcus multilocularis muscleblind protein 0.0149 0.2708 0.2655
Loa Loa (eye worm) hypothetical protein 0.0015 0.0071 0.0036
Trypanosoma cruzi hexose transporter, putative 0.0033 0.0421 0.5949
Loa Loa (eye worm) hypothetical protein 0.0149 0.2708 0.2682
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0021 0.019 0.012
Schistosoma mansoni protein kinase 0.0034 0.0442 0.0373
Leishmania major protein kinase, putative 0.0034 0.0442 0.6313
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0034 0.0442 0.0437
Brugia malayi Cam kinase protein 1 0.0034 0.0442 0.0373
Echinococcus granulosus calcium dependent protein kinase 0.003 0.0374 0.0304
Loa Loa (eye worm) hypothetical protein 0.0015 0.0071 0.0036
Loa Loa (eye worm) hypothetical protein 0.0015 0.0071 0.0036
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0034 0.0442 0.0437
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0034 0.0442 0.0667
Onchocerca volvulus 0.0048 0.0726 0.066
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0421 0.1973
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.016 0.1904
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0405 0.0336
Echinococcus multilocularis lysyl tRNA synthetase 0.0023 0.0242 0.0171
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.01 0.1747 0.1688
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0032 0.04 0.0331
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0105 0.1843 0.1784
Loa Loa (eye worm) hypothetical protein 0.0015 0.0071 0.0036
Trypanosoma brucei sugar transporter, putative 0.0015 0.0071 0.0472
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0242 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.01 0.1747 0.1688
Leishmania major lysyl-tRNA synthetase, putative 0.0023 0.0242 0.2899
Trypanosoma brucei glucose transporter, putative 0.0033 0.0421 0.614
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0034 0.0442 0.0373
Entamoeba histolytica hypothetical protein 0.0023 0.0242 0.2902
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.016 0.1904
Leishmania major glucose transporter, lmgt1 0.0033 0.0421 0.5949
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.01 0.1747 0.1688
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0105 0.1843 0.1784
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0521 1 1
Plasmodium vivax CDK-related protein kinase 6, putative 0.0448 0.8558 1
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0105 0.1843 0.1784
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0021 0.019 0.7869
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0021 0.0185 0.0641
Echinococcus granulosus lysyl tRNA synthetase 0.0023 0.0242 0.0171
Brugia malayi Sugar transporter family protein 0.0105 0.1843 0.1784
Schistosoma mansoni Smad4 0.0017 0.0115 0.0044
Schistosoma mansoni hypothetical protein 0.0069 0.1127 0.1064
Schistosoma mansoni glucose transport protein 0.0105 0.1843 0.1784
Plasmodium falciparum protein kinase 6 0.0448 0.8558 1
Echinococcus granulosus survival motor neuron protein 1 0.0236 0.4414 0.4374
Echinococcus multilocularis smad 0.0017 0.0115 0.0044
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.016 0.1904
Schistosoma mansoni smad1 5 8 and 0.0017 0.0115 0.0044
Trypanosoma brucei glucose transporter, putative 0.0033 0.0421 0.614
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0105 0.1843 0.1784
Echinococcus granulosus Smad4 0.0017 0.0115 0.0044
Chlamydia trachomatis lysine--tRNA ligase 0.0023 0.0242 1
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0034 0.0442 0.0373
Onchocerca volvulus 0.0252 0.4712 0.4674
Loa Loa (eye worm) hypothetical protein 0.0069 0.1127 0.1096
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.016 0.1904
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0405 0.0336
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.016 0.1904
Schistosoma mansoni protein kinase 0.0034 0.0442 0.0373
Echinococcus multilocularis General substrate transporter 0.009 0.1553 0.1492
Trypanosoma brucei glucose transporter, putative 0.0033 0.0421 0.614
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0242 0.0171
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0726 0.066
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.016 0.7434
Leishmania major glucose transporter, lmgt3 0.0033 0.0421 0.5949
Brugia malayi MH2 domain containing protein 0.025 0.4682 0.4644
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0034 0.0442 0.0373
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0032 0.04 0.1855
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.016 0.0089
Leishmania major DNA polymerase kappa, putative 0.0019 0.016 0.1503
Echinococcus granulosus GPCR family 2 0.0032 0.0405 0.0336
Schistosoma mansoni ap endonuclease 0.0021 0.019 0.012
Loa Loa (eye worm) major facilitator superfamily transporter 0.0015 0.0071 0.0036
Brugia malayi ImpB/MucB/SamB family protein 0.0045 0.0659 0.0592
Leishmania major DNA polymerase eta, putative 0.0045 0.0659 1
Loa Loa (eye worm) pax transcription factor protein 2 0.0252 0.4712 0.4693
Schistosoma mansoni survival motor neuron protein 0.0048 0.0726 0.066
Trypanosoma cruzi hexose transporter, putative 0.0018 0.0131 0.1015
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0034 0.0442 0.0408
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0521 1 1
Loa Loa (eye worm) sugar transporter 0.0105 0.1843 0.1814
Loa Loa (eye worm) hypothetical protein 0.0015 0.0071 0.0036
Trypanosoma cruzi DNA polymerase eta, putative 0.0031 0.0398 0.5561
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.016 0.0498
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.016 0.6608
Brugia malayi Smad1 0.0017 0.0115 0.0044
Giardia lamblia Lysyl-tRNA synthetase 0.0023 0.0242 0.5182
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0421 0.1973
Plasmodium falciparum calcium-dependent protein kinase 2 0.0034 0.0442 0.0437
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0032 0.04 0.0331
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.01 0.1747 0.1688
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0034 0.0442 0.0667
Plasmodium falciparum mitogen-activated protein kinase 2 0.0171 0.3141 0.3617
Loa Loa (eye worm) sugar transporter 0.0015 0.0071 0.0036
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0015 0.0071 0.2954
Loa Loa (eye worm) hypothetical protein 0.0236 0.4414 0.4394
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0034 0.0442 0.0373
Plasmodium falciparum calcium-dependent protein kinase 1 0.0034 0.0442 0.0437
Schistosoma mansoni hypothetical protein 0.0048 0.0726 0.066
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0171 0.3141 0.5519
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.016 0.7434
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0023 0.0242 0.3046
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0421 0.1973
Loa Loa (eye worm) hypothetical protein 0.0015 0.0071 0.0036
Schistosoma mansoni glucose transport protein 0.0105 0.1843 0.1784
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0021 0.019 0.2022
Echinococcus granulosus General substrate transporter 0.009 0.1553 0.1492
Trichomonas vaginalis conserved hypothetical protein 0.0105 0.1843 1
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0034 0.0442 0.0373
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0037 0.0502 0.0775
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0034 0.0442 0.0373
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0034 0.0442 0.0408
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0034 0.0442 0.0373
Trichomonas vaginalis CAMK family protein kinase 0.0034 0.0442 0.2093
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.002 0.0172 0.8497
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0105 0.1843 0.1784
Brugia malayi MH1 domain containing protein 0.0017 0.0115 0.0044
Loa Loa (eye worm) hypothetical protein 0.0015 0.0071 0.0036
Trypanosoma brucei THT1 - hexose transporter, putative 0.0033 0.0421 0.614
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0017 0.0115 0.0044
Trypanosoma brucei glucose transporter 2A 0.0033 0.0421 0.614
Toxoplasma gondii lysine-tRNA ligase 0.0023 0.0242 0.0306
Schistosoma mansoni DNA polymerase eta 0.0045 0.0659 0.0592
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.01 0.1747 0.1688
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0034 0.0442 0.0667
Echinococcus multilocularis dna polymerase kappa 0.0019 0.016 0.0089
Loa Loa (eye worm) Smad1 0.0017 0.0115 0.008
Schistosoma mansoni glucose transport protein 0.0105 0.1843 0.1784
Plasmodium falciparum calcium-dependent protein kinase 4 0.0034 0.0442 0.0437
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0021 0.019 1
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0242 1
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.016 0.0089
Plasmodium falciparum calcium-dependent protein kinase 5 0.0034 0.0442 0.0437
Loa Loa (eye worm) hypothetical protein 0.01 0.175 0.1721
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0023 0.0242 0.0961
Loa Loa (eye worm) pigment dispersing factor receptor c 0.01 0.175 0.1721
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0171 0.3141 0.3617
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0105 0.1843 0.1784
Trypanosoma brucei glucose transporter, putative 0.0033 0.0421 0.614
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0032 0.04 0.8505
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.016 0.1503
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0037 0.0502 0.7338
Schistosoma mansoni hypothetical protein 0.0032 0.0405 0.0336
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0405 0.0336
Loa Loa (eye worm) MH1 domain-containing protein 0.0017 0.0115 0.008
Toxoplasma gondii exonuclease III APE 0.0021 0.019 0.0213
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.01 0.1747 0.1688
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.016 0.1904
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.016 0.1904
Echinococcus granulosus smad 0.0017 0.0115 0.0044
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0031 0.0398 0.0587
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.016 0.1904
Trypanosoma brucei glucose transporter, putative 0.0033 0.0421 0.614
Mycobacterium ulcerans integral membrane transport protein 0.0015 0.0071 0.2954
Treponema pallidum exodeoxyribonuclease (exoA) 0.0021 0.019 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0071 0.0036
Echinococcus granulosus mothers against decapentaplegic 5 0.0017 0.0115 0.0044
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.016 0.0089
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.01 0.1747 0.1688
Leishmania major DNA polymerase eta, putative 0.0031 0.0398 0.5561
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0034 0.0442 0.0437
Echinococcus granulosus dna polymerase kappa 0.0019 0.016 0.0089
Trypanosoma brucei unspecified product 0.0019 0.016 0.1904
Loa Loa (eye worm) hypothetical protein 0.0015 0.0071 0.0036
Trichomonas vaginalis glucose transporter, putative 0.0033 0.0421 0.1973
Trypanosoma brucei THT1 - hexose transporter, putative 0.0033 0.0421 0.614
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0421 0.1973
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0015 0.0071 0.0472
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0034 0.0442 0.0373
Echinococcus multilocularis calcium dependent protein kinase 0.003 0.0374 0.0304
Entamoeba histolytica protein kinase, putative 0.0034 0.0442 1
Plasmodium falciparum calcium-dependent protein kinase 3 0.0034 0.0442 0.0437
Trypanosoma cruzi hexose transporter, putative 0.0033 0.0421 0.5949
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0015 0.0071 0.2954
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0037 0.0502 0.7338
Plasmodium vivax proline--tRNA ligase, putative 0.0037 0.0502 0.0508
Loa Loa (eye worm) MH2 domain-containing protein 0.025 0.4682 0.4663
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.016 0.1503
Schistosoma mansoni hypothetical protein 0.0032 0.0405 0.0336
Loa Loa (eye worm) hypothetical protein 0.0032 0.04 0.0366
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.016 0.1503
Trichomonas vaginalis glucose transporter, putative 0.0033 0.0421 0.1973
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0021 0.019 0.0155
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0023 0.0242 0.3233
Loa Loa (eye worm) hypothetical protein 0.0034 0.0442 0.0408
Loa Loa (eye worm) hypothetical protein 0.0015 0.0071 0.0036
Brugia malayi MH2 domain containing protein 0.0017 0.0115 0.0044
Schistosoma mansoni serine/threonine protein kinase 0.0034 0.0442 0.0373
Plasmodium vivax lysine--tRNA ligase, putative 0.0023 0.0242 0.0201
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0021 0.019 0.3614
Schistosoma mansoni hypothetical protein 0.0105 0.1843 0.1784
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0405 0.0336
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.016 0.0498
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0405 0.037
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.016 0.0125
Brugia malayi latrophilin 2 splice variant baaae 0.0069 0.1127 0.1064

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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