Detailed information for compound 652262

Basic information

Technical information
  • TDR Targets ID: 652262
  • Name: ethyl 5-[10-(5-ethoxy-5-oxopentanoyl)-1,7-dio xa-4,10-diazacyclododec-4-yl]-5-oxopentanoate
  • MW: 458.546 | Formula: C22H38N2O8
  • H donors: 0 H acceptors: 4 LogP: -0.34 Rotable bonds: 14
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)CCCC(=O)N1CCOCCN(CCOCC1)C(=O)CCCC(=O)OCC
  • InChi: 1S/C22H38N2O8/c1-3-31-21(27)9-5-7-19(25)23-11-15-29-17-13-24(14-18-30-16-12-23)20(26)8-6-10-22(28)32-4-2/h3-18H2,1-2H3
  • InChiKey: JHXFARNONSKPTO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • ethyl 5-[10-(5-ethoxy-5-oxo-pentanoyl)-1,7-dioxa-4,10-diazacyclododec-4-yl]-5-oxo-pentanoate
  • 5-[10-(5-ethoxy-1,5-dioxopentyl)-1,7-dioxa-4,10-diazacyclododec-4-yl]-5-oxopentanoic acid ethyl ester
  • 5-[10-(5-ethoxy-5-keto-pentanoyl)-1,7-dioxa-4,10-diazacyclododec-4-yl]-5-keto-valeric acid ethyl ester
  • BAS 00227968
  • STOCK3S-15425

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus single minded 2 0.004 0.0485 0.0485
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0075 0.0075
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0693 0.0693
Onchocerca volvulus 0.002 0.0191 0.028
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0052 0.0644 0.1539
Schistosoma mansoni hypothetical protein 0.0016 0.0146 0.0146
Brugia malayi Cytochrome P450 family protein 0.004 0.0485 0.1159
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0693 0.0693
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0011 0.0075 0.0075
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0075 0.018
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0011 0.0075 0.018
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0045 0.0045
Echinococcus granulosus cpg binding protein 0.0032 0.0359 0.0359
Schistosoma mansoni cpg binding protein 0.0032 0.0359 0.0359
Mycobacterium leprae putative cytochrome p450 0.0022 0.0224 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0011 0.0000000045567
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0116 0.0252
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0191 0.0191
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0146 0.0146
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0014 0.0116 0.0252
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0015 0.0122 0.0017
Loa Loa (eye worm) hypothetical protein 0.0011 0.0075 0.018
Loa Loa (eye worm) cytochrome P450 family protein 0.004 0.0485 0.1159
Echinococcus granulosus aryl hydrocarbon receptor 0.0014 0.0116 0.0116
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0693 0.0693
Loa Loa (eye worm) hypothetical protein 0.002 0.0191 0.0456
Loa Loa (eye worm) hypothetical protein 0.002 0.0191 0.0456
Schistosoma mansoni hypothetical protein 0.0016 0.0146 0.0146
Leishmania major eukaryotic initiation factor 4a, putative 0.0303 0.4186 1
Plasmodium vivax RNA helicase-1, putative 0.0303 0.4186 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0023 0.0235 0.0294
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0014 0.0116 0.0252
Schistosoma mansoni RAR-like nuclear receptor 0.0011 0.0075 0.0075
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.0303 0.4186 0.4186
Schistosoma mansoni aryl hydrocarbon receptor 0.0055 0.0686 0.0686
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0023 0.0235 0.0294
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0075 0.018
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.0303 0.4186 0.4186
Schistosoma mansoni steroid hormone receptor ad4bp 0.0011 0.0075 0.0075
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0011 0.0075 0.018
Trypanosoma brucei Eukaryotic initiation factor 4A-1 0.0303 0.4186 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0011 0.0075 0.0075
Leishmania major cytochrome p450-like protein 0.0022 0.0224 0.0267
Schistosoma mansoni microtubule-associated protein tau 0.0716 1 1
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0303 0.4186 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0063 0.0806 0.0806
Echinococcus granulosus mitogen activated protein kinase 3 0.0053 0.0668 0.0668
Schistosoma mansoni nuclear hormone receptor 0.0011 0.0075 0.0075
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0011 0.0075 0.018
Trichomonas vaginalis adenylate cyclase, putative 0.0014 0.0116 0.0252
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0053 0.0668 0.1357
Schistosoma mansoni cytochrome P450 0.0022 0.0224 0.0224
Loa Loa (eye worm) hypothetical protein 0.0019 0.0176 0.0422
Brugia malayi nuclear hormone receptor 0.0011 0.0075 0.018
Loa Loa (eye worm) hypothetical protein 0.0011 0.0075 0.018
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0023 0.0235 0.0028
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0023 0.0235 0.0425
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0011 0.0075 0.018
Onchocerca volvulus 0.003 0.0335 0.0632
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0014 0.0116 0.0116
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0075 0.0075
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0023 0.0235 0.0235
Schistosoma mansoni serine/threonine protein kinase 0.0053 0.0668 0.0668
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0053 0.0668 0.1357
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0011 0.0075 0.0075
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0011 0.0075 0.0075
Schistosoma mansoni cpg binding protein 0.003 0.0335 0.0335
Brugia malayi Doublecortin family protein 0.002 0.0191 0.0456
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0053 0.0668 0.112
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0007 0.002 0.002
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0015 0.0122 0.0017
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0007 0.002 0.002
Loa Loa (eye worm) hypoxia-induced factor 1 0.0169 0.2299 0.5492
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0413 0.0988
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0053 0.0668 0.1357
Schistosoma mansoni cpg binding protein 0.0032 0.0359 0.0359
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0011 0.0075 0.018
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0014 0.0116 0.0252
Echinococcus granulosus mitogen activated protein kinase 0.0053 0.0668 0.0668
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0011 0.0075 0.0075
Schistosoma mansoni hypothetical protein 0.0037 0.0441 0.0441
Brugia malayi exodeoxyribonuclease III family protein 0.0023 0.0235 0.0562
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0011 0.0075 0.018
Brugia malayi hypothetical protein 0.002 0.0191 0.0456
Onchocerca volvulus 0.002 0.0191 0.028
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0441 0.0441
Echinococcus multilocularis aryl hydrocarbon receptor 0.0014 0.0116 0.0116
Schistosoma mansoni lipoxygenase 0.002 0.0191 0.0191
Plasmodium falciparum eukaryotic initiation factor 4A 0.0303 0.4186 1
Schistosoma mansoni single-minded 0.0055 0.0686 0.0686
Loa Loa (eye worm) hypothetical protein 0.0035 0.0413 0.0988
Echinococcus granulosus RUN 0.002 0.0191 0.0191
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0011 0.0075 0.0075
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0053 0.0668 0.112
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0693 0.0693
Toxoplasma gondii histone lysine methyltransferase SET1 0.0056 0.0711 0.1228
Leishmania major protein kinase, putative 0.0015 0.0122 0.0017
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0014 0.0116 0.0276
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0022 0.0224 0.0267
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0116 0.0252
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0053 0.0668 0.1595
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0075 0.018
Schistosoma mansoni hypothetical protein 0.0022 0.0224 0.0224
Echinococcus multilocularis ecdysone induced protein 78C 0.0011 0.0075 0.0075
Loa Loa (eye worm) CYP4Cod1 0.004 0.0485 0.1159
Leishmania major cytochrome p450-like protein 0.004 0.0485 0.0908
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0075 0.018
Schistosoma mansoni loxhd1 0.002 0.0191 0.0191
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0235 0.0112
Brugia malayi MAP kinase sur-1 0.0053 0.0668 0.1595
Schistosoma mansoni hypothetical protein 0.0016 0.0146 0.0146
Leishmania major cytochrome p450-like protein 0.0022 0.0224 0.0267
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0007 0.002 0.002
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0191 0.0191
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0023 0.0235 0.0235
Brugia malayi hypothetical protein 0.0183 0.2499 0.597
Entamoeba histolytica hypothetical protein 0.0037 0.0441 0.0521
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0023 0.0235 0.0562
Echinococcus multilocularis eukaryotic initiation factor 4A 0.0303 0.4186 0.4186
Loa Loa (eye worm) hypothetical protein 0.0011 0.0075 0.018
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0011 0.0075 0.0075
Mycobacterium leprae Conserved hypothetical protein 0.0022 0.0224 1
Schistosoma mansoni hypothetical protein 0.0035 0.0413 0.0413
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0146 0.0349
Echinococcus granulosus Polycystic kidney disease protein 0.002 0.0191 0.0191
Echinococcus multilocularis geminin 0.0176 0.2392 0.2392
Schistosoma mansoni hypothetical protein 0.0016 0.0146 0.0146
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0235 0.0538
Giardia lamblia Translation initiation factor eIF-4A, putative 0.0303 0.4186 1
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0191 0.0191
Entamoeba histolytica hypothetical protein 0.0037 0.0441 0.0521
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0011 0.0075 0.018
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0693 0.0693
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0011 0.0075 0.018
Schistosoma mansoni rab6-interacting 0.002 0.0191 0.0191
Leishmania major protein kinase, putative 0.0015 0.0122 0.0017
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.0303 0.4186 1
Onchocerca volvulus 0.004 0.0485 0.0997
Toxoplasma gondii eukaryotic initiation factor-4A, putative 0.0303 0.4186 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0011 0.0000000045567
Loa Loa (eye worm) hypothetical protein 0.0303 0.4186 1
Trypanosoma brucei cytochrome P450, putative 0.004 0.0485 0.0659
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0303 0.4186 1
Entamoeba histolytica hypothetical protein 0.0037 0.0441 0.0521
Loa Loa (eye worm) doublecortin family protein 0.002 0.0191 0.0456
Loa Loa (eye worm) hypothetical protein 0.0014 0.0116 0.0276
Loa Loa (eye worm) hypothetical protein 0.0016 0.0146 0.0349
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0011 0.0000000045567
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0693 0.0693
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0045 0.0045
Echinococcus multilocularis thyroid hormone receptor alpha 0.0011 0.0075 0.0075
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0011 0.0000000045567
Brugia malayi hypothetical protein 0.0037 0.0441 0.1054
Echinococcus multilocularis GPCR, family 2 0.0016 0.0146 0.0146
Echinococcus multilocularis neuropeptide receptor A26 0.048 0.6673 0.6673
Loa Loa (eye worm) pax transcription factor protein 2 0.0253 0.3478 0.831
Onchocerca volvulus Eukaryotic initiation factor 4A homolog 0.0303 0.4186 1
Brugia malayi hypoxia-induced factor 1 0.0169 0.2299 0.5492
Echinococcus multilocularis Polycystic kidney disease protein 0.002 0.0191 0.0191
Leishmania major eukaryotic initiation factor 4a, putative 0.0303 0.4186 1
Brugia malayi Steroid receptor seven-up type 2 0.0011 0.0075 0.018
Echinococcus multilocularis neuropeptide s receptor 0.048 0.6673 0.6673
Onchocerca volvulus 0.0253 0.3478 0.8279
Loa Loa (eye worm) cytochrome P450 family protein 0.0081 0.1054 0.2518
Brugia malayi Calcitonin receptor-like protein seb-1 0.0052 0.0644 0.1539
Echinococcus granulosus eukaryotic initiation factor 4A III 0.0303 0.4186 0.4186
Echinococcus multilocularis RUN 0.002 0.0191 0.0191
Echinococcus granulosus mixed lineage leukemia protein mll 0.0007 0.002 0.002
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0011 0.0000000045567
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0023 0.0235 0.0294
Echinococcus granulosus FTZ F1 alpha 0.0011 0.0075 0.0075
Schistosoma mansoni hypothetical protein 0.0424 0.5893 0.5893
Mycobacterium ulcerans putative regulatory protein 0.004 0.0485 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0075 0.0075
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0014 0.0116 0.0116
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0075 0.018
Echinococcus granulosus dnaJ subfamily B 0.0424 0.5893 0.5893
Echinococcus multilocularis FTZ F1 alpha 0.0011 0.0075 0.0075
Echinococcus multilocularis microtubule associated protein 2 0.0716 1 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0693 0.1657
Echinococcus granulosus neuropeptide receptor A26 0.048 0.6673 0.6673
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0075 0.018
Schistosoma mansoni hypothetical protein 0.002 0.0191 0.0191
Echinococcus multilocularis cpg binding protein 0.0032 0.0359 0.0359
Schistosoma mansoni ap endonuclease 0.0023 0.0235 0.0235
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0007 0.002 0.002
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0011 0.0000000045567
Trichomonas vaginalis guanylate cyclase, putative 0.0014 0.0116 0.0252
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0075 0.018
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0011 0.0075 0.018
Loa Loa (eye worm) hypothetical protein 0.0011 0.0075 0.018
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0011 0.0075 0.0075
Echinococcus granulosus GPCR family 2 0.0016 0.0146 0.0146
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0015 0.0122 0.0017
Loa Loa (eye worm) hypothetical protein 0.0011 0.0075 0.018
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0075 0.0075
Schistosoma mansoni retinoic acid receptor RXR 0.0011 0.0075 0.0075
Brugia malayi hypothetical protein 0.002 0.0191 0.0456
Loa Loa (eye worm) hypothetical protein 0.0011 0.0075 0.018
Mycobacterium tuberculosis Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) 0.0303 0.4186 1
Brugia malayi nuclear receptor NHR-88 0.0011 0.0075 0.018
Echinococcus multilocularis mitogen activated protein kinase 0.0053 0.0668 0.0668
Loa Loa (eye worm) cytochrome P450 family protein 0.004 0.0485 0.1159
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0191 0.0191
Schistosoma mansoni hypothetical protein 0.0176 0.2392 0.2392
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0011 0.0000000045567
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0668 0.1574
Echinococcus granulosus geminin 0.0176 0.2392 0.2392
Echinococcus multilocularis eukaryotic initiation factor 4A III 0.0303 0.4186 0.4186
Echinococcus granulosus cytochrome P450 2K1 0.0022 0.0224 0.0224
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0014 0.0116 0.0252
Brugia malayi steroid hormone receptor 0.0011 0.0075 0.018
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0693 0.1657
Loa Loa (eye worm) hypothetical protein 0.0011 0.0075 0.018
Brugia malayi Cytochrome P450 family protein 0.0081 0.1054 0.2518
Schistosoma mansoni rab6-interacting 0.002 0.0191 0.0191
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0022 0.0224 0.0267
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0011 0.0075 0.018
Entamoeba histolytica DEAD/DEAH box helicase, putative 0.0303 0.4186 1
Trypanosoma brucei protein kinase, putative 0.0053 0.0668 0.112
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0053 0.0668 0.1357
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0055 0.0686 0.0686
Schistosoma mansoni lipoxygenase 0.0055 0.0686 0.0686
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0335 0.0801
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0075 0.0075
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0235 0.0112
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0044 0.0104
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0075 0.0075
Echinococcus granulosus neuropeptide s receptor 0.048 0.6673 0.6673
Brugia malayi Pax transcription factor protein 2 0.0253 0.3478 0.831
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0011 0.0075 0.018
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.004 0.0485 0.9993
Brugia malayi photoreceptor-specific nuclear receptor 0.0011 0.0075 0.018
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0011 0.0075 0.0075
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0075 0.0075
Brugia malayi Cytochrome P450 family protein 0.004 0.0485 0.1159
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0146 0.0349
Schistosoma mansoni polycystin 1-related 0.002 0.0191 0.0191
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0303 0.4186 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0011 0.0075 0.0075
Echinococcus granulosus ecdysone induced protein 78C 0.0011 0.0075 0.0075
Toxoplasma gondii exonuclease III APE 0.0023 0.0235 0.0028
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0146 0.0146
Giardia lamblia Kinase, CMGC MAPK 0.0053 0.0668 0.1095
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0023 0.0235 0.5
Loa Loa (eye worm) hypothetical protein 0.0183 0.2499 0.597
Trypanosoma cruzi cytochrome P450, putative 0.004 0.0485 0.0908
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0146 0.0146
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0011 0.0075 0.018
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.0303 0.4186 1
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0023 0.0235 0.0028
Loa Loa (eye worm) cytochrome P450 0.0022 0.0224 0.0536
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0668 0.1574
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0055 0.0686 0.0686
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0011 0.0075 0.0075
Brugia malayi eukaryotic initiation factor 4A 0.0303 0.4186 1
Schistosoma mansoni coup transcription factor 0.0011 0.0075 0.0075
Schistosoma mansoni ap endonuclease 0.0023 0.0235 0.0235
Loa Loa (eye worm) steroid hormone receptor 0.0011 0.0075 0.018
Entamoeba histolytica hypothetical protein 0.0037 0.0441 0.0521
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0011 0.0075 0.018
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0146 0.0349
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0693 0.0693
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0011 0.0075 0.0075
Echinococcus granulosus eukaryotic initiation factor 4A 0.0303 0.4186 0.4186
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0014 0.0116 0.5
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0014 0.0116 0.0252
Echinococcus multilocularis dnaJ subfamily B 0.0424 0.5893 0.5893
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0441 0.0441
Echinococcus multilocularis mitogen activated protein kinase 3 0.0053 0.0668 0.0668
Trypanosoma cruzi cytochrome P450, putative 0.004 0.0485 0.0908
Echinococcus multilocularis 0.0022 0.0224 0.0224
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0045 0.0108
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0011 0.0075 0.018
Schistosoma mansoni hypothetical protein 0.0176 0.2392 0.2392
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0052 0.0644 0.1539
Trichomonas vaginalis guanylate cyclase, putative 0.0014 0.0116 0.0252
Brugia malayi PAS domain containing protein 0.0055 0.0686 0.1638
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0668 0.1574
Treponema pallidum ATP-dependent RNA helicase 0.0303 0.4186 1
Brugia malayi Cytochrome P450 family protein 0.0022 0.0224 0.0536
Brugia malayi cytochrome P450 0.0022 0.0224 0.0536
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0011 0.0000000045567
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0441 0.0441
Brugia malayi CXXC zinc finger family protein 0.003 0.0335 0.0801
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0015 0.0122 0.0017
Brugia malayi bHLH-PAS transcription factor 0.004 0.0485 0.116
Brugia malayi ecdysteroid receptor 0.0011 0.0075 0.018
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0053 0.0668 0.1357
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0668 0.1574
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0011 0.0075 0.0075
Loa Loa (eye worm) hypothetical protein 0.0052 0.0644 0.1539
Echinococcus multilocularis transfer RNA-Lys 0.004 0.0485 0.0485
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0235 0.0538
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0116 0.0252
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0022 0.0224 0.0267
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0053 0.0668 0.1357
Loa Loa (eye worm) hypothetical protein 0.0011 0.0075 0.018
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0011 0.0075 0.0075
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0146 0.0146
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0022 0.0224 0.0267
Onchocerca volvulus 0.0014 0.0116 0.0098

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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