TDR Targets

Basic information

Technical information

TDR Targets ID: 652897
Name: N-(4-methoxyphenyl)-2-(3-methylphenyl)-1,3-di oxoisoindole-5-carboxamide
MW: 386.4 | Formula: C23H18N2O4
H donors: 1 H acceptors: 3 LogP: 3.63 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccc(cc1)NC(=O)c1ccc2c(c1)C(=O)N(C2=O)c1cccc(c1)C
InChi: 1S/C23H18N2O4/c1-14-4-3-5-17(12-14)25-22(27)19-11-6-15(13-20(19)23(25)28)21(26)24-16-7-9-18(29-2)10-8-16/h3-13H,1-2H3,(H,24,26)
InChiKey: IQUPRGHBMJRRCM-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-(4-methoxyphenyl)-2-(3-methylphenyl)-1,3-dioxo-isoindoline-5-carboxamide
N-(4-methoxyphenyl)-2-(3-methylphenyl)-1,3-dioxo-5-isoindolinecarboxamide
1,3-diketo-N-(4-methoxyphenyl)-2-(3-methylphenyl)isoindoline-5-carboxamide
N-(4-methoxyphenyl)-2-(3-methylphenyl)-1,3-dioxo-isoindole-5-carboxamide
Oprea1_135023
ZINC01213439
BIM-0000174.P001
CBMicro_000023

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0022	0.0063
Brugia malayi	Patched family protein	0.0006	0.0041	0.0117
Loa Loa (eye worm)	hypothetical protein	0.0012	0.019	0.0545
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0041	0.0117
Trichomonas vaginalis	conserved hypothetical protein	0.0043	0.0937	0.2456
Mycobacterium leprae	PROBABLE ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE BIOA	0.0155	0.3649	1
Echinococcus granulosus	Protein patched homolog 1	0.0043	0.0937	0.0917
Brugia malayi	Patched related family protein 4	0.0006	0.0041	0.0117
Onchocerca volvulus		0.0029	0.0603	1
Brugia malayi	Patched family protein	0.0006	0.0041	0.0117
Plasmodium vivax	histone acetyltransferase GCN5, putative	0.0044	0.0952	1
Brugia malayi	Intermediate filament tail domain containing protein	0.0026	0.0533	0.1527
Brugia malayi	intermediate filament protein	0.0026	0.0533	0.1527
Echinococcus multilocularis	dnaJ subfamily B	0.0417	1	1
Brugia malayi	Bromodomain containing protein	0.0005	0.0022	0.0063
Echinococcus granulosus	Aminotransferase class III	0.0022	0.0427	0.0406
Brugia malayi	MH1 domain containing protein	0.0008	0.0086	0.0247
Schistosoma mansoni	hypothetical protein	0.0042	0.09	0.088
Schistosoma mansoni	TGF-beta signal transducer Smad2	0.0008	0.0086	0.0065
Echinococcus multilocularis	Niemann Pick C1 protein	0.01	0.2326	0.2309
Echinococcus multilocularis	ornithine aminotransferase	0.0022	0.0427	0.0406
Brugia malayi	PHD-finger family protein	0.0005	0.0022	0.0063
Echinococcus granulosus	lamin dm0	0.0026	0.0533	0.0513
Echinococcus multilocularis	protein patched	0.0043	0.0937	0.0917
Echinococcus multilocularis	expressed conserved protein	0.0094	0.2178	0.2161
Brugia malayi	Patched family protein	0.0006	0.0041	0.0117
Schistosoma mansoni	smad1 5 8 and	0.0008	0.0086	0.0065
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0041	0.0117
Loa Loa (eye worm)	hypothetical protein	0.01	0.2326	0.6657
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0202	0.0579
Echinococcus granulosus	TGF beta signal transducer SmadC	0.0008	0.0086	0.0065
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0041	0.0117
Schistosoma mansoni	intermediate filament proteins	0.0026	0.0533	0.0513
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0041	0.0117
Brugia malayi	protein C24B5.3	0.0006	0.0041	0.0117
Loa Loa (eye worm)	MH1 domain-containing protein	0.0008	0.0086	0.0247
Mycobacterium tuberculosis	Probable aminotransferase	0.0155	0.3649	1
Brugia malayi	Patched family protein	0.0006	0.0041	0.0117
Schistosoma mansoni	hypothetical protein	0.0042	0.09	0.088
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0029	0.0603	0.1725
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0041	0.0117
Loa Loa (eye worm)	MH2 domain-containing protein	0.0008	0.0086	0.0247
Loa Loa (eye worm)	MH2 domain-containing protein	0.0117	0.2728	0.7807
Mycobacterium ulcerans	hypothetical protein	0.0155	0.3649	1
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.01	0.2326	1
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0041	0.0117
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	0.0044	0.0952	0.7092
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	0.0044	0.0952	0.7092
Brugia malayi	F/Y-rich N-terminus family protein	0.0009	0.011	0.0315
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0043	0.0937	0.2682
Loa Loa (eye worm)	patched family protein	0.0006	0.0041	0.0117
Brugia malayi	MH2 domain containing protein	0.0117	0.2728	0.7807
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.0149	0.3494	0.348
Schistosoma mansoni	lamin	0.0026	0.0533	0.0513
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0062	0.1398	0.138
Schistosoma mansoni	cpg binding protein	0.0031	0.0643	0.0623
Echinococcus multilocularis	Aminotransferase class III	0.0022	0.0427	0.0406
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0041	0.0117
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0041	0.0117
Brugia malayi	Myosin head containing protein	0.0006	0.0041	0.0117
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0059	0.1326	1
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0041	0.0117
Brugia malayi	hypothetical protein	0.0006	0.0041	0.0117
Echinococcus granulosus	geminin	0.0173	0.408	0.4067
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0041	0.0117
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0041	0.0117
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0009	0.0113	0.0091
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0041	0.0117
Echinococcus multilocularis	TGF beta signal transducer SmadC	0.0008	0.0086	0.0065
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0041	0.0117
Brugia malayi	Patched family protein	0.0006	0.0041	0.0117
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0041	0.0117
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0044	0.0952	0.2498
Echinococcus granulosus	sterol regulatory element binding protein	0.0043	0.0937	0.0917
Brugia malayi	Patched family protein	0.0006	0.0041	0.0117
Brugia malayi	Patched family protein	0.0006	0.0041	0.0117
Onchocerca volvulus		0.0026	0.0533	0.8766
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0026	0.0533	0.1527
Plasmodium falciparum	ornithine aminotransferase	0.0022	0.0427	0.4695
Toxoplasma gondii	ornithine aminotransferase, mitochondrial precursor, putative	0.0022	0.0427	0.3007
Loa Loa (eye worm)	intermediate filament protein	0.0026	0.0533	0.1527
Schistosoma mansoni	hypothetical protein	0.0417	1	1
Echinococcus multilocularis	smad	0.0008	0.0086	0.0065
Brugia malayi	hypothetical protein	0.0006	0.0041	0.0117
Schistosoma mansoni	hypothetical protein	0.0042	0.09	0.088
Brugia malayi	Patched protein homolog 1	0.0006	0.0041	0.0117
Schistosoma mansoni	hypothetical protein	0.0173	0.408	0.4067
Schistosoma mansoni	hypothetical protein	0.0173	0.408	0.4067
Echinococcus multilocularis	lamin	0.0026	0.0533	0.0513
Mycobacterium ulcerans	adenosylmethionine-8-amino-7-oxononanoate aminotransferase	0.0155	0.3649	1
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0041	0.0117
Schistosoma mansoni	smad1 5 8 and	0.0008	0.0086	0.0065
Brugia malayi	hypothetical protein	0.0006	0.0041	0.0117
Brugia malayi	acetyltransferase, GNAT family protein	0.0149	0.3494	1
Echinococcus granulosus	mixed lineage leukemia protein mll	0.0007	0.0069	0.0048
Loa Loa (eye worm)	Smad1	0.0008	0.0086	0.0247
Wolbachia endosymbiont of Brugia malayi	acetylornithine transaminase protein	0.0022	0.0427	0.5
Brugia malayi	Patched family protein	0.0006	0.0041	0.0117
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0533	0.1527
Brugia malayi	CXXC zinc finger family protein	0.0029	0.0603	0.1725
Echinococcus multilocularis	protein dispatched 1	0.0049	0.1085	0.1065
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.0149	0.3494	0.348
Brugia malayi	CHE-14 protein	0.0043	0.0937	0.2682
Echinococcus multilocularis	lamin dm0	0.0026	0.0533	0.0513
Echinococcus multilocularis	sterol regulatory element binding protein	0.0043	0.0937	0.0917
Giardia lamblia	Histone acetyltransferase GCN5	0.004	0.0864	0.5
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0041	0.0117
Echinococcus granulosus	Niemann Pick C1 protein	0.0144	0.337	0.3355
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0041	0.0117
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0007	0.0069	0.0048
Echinococcus granulosus	intermediate filament protein	0.0026	0.0533	0.0513
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0013	0.0202	0.0181
Plasmodium vivax	ornithine aminotransferase, putative	0.0022	0.0427	0.4241
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0102	0.2364	0.2347
Echinococcus multilocularis	mixed lineage leukemia protein mll	0.0007	0.0069	0.0048
Echinococcus multilocularis	ornithine aminotransferase	0.0022	0.0427	0.0406
Echinococcus granulosus	expressed conserved protein	0.0094	0.2178	0.2161
Loa Loa (eye worm)	hypothetical protein	0.0012	0.019	0.0545
Brugia malayi	Patched family protein	0.0006	0.0041	0.0117
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0144	0.3393	0.3378
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0041	0.0117
Chlamydia trachomatis	glutamate-1-semialdehyde-2,1-aminomutase	0.0022	0.0427	0.5
Echinococcus multilocularis	mothers against decapentaplegic 5	0.0008	0.0086	0.0065
Echinococcus granulosus	smad	0.0008	0.0086	0.0065
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0014	0.0236	0.0676
Echinococcus multilocularis	Smad4	0.0008	0.0086	0.0065
Brugia malayi	Patched family protein	0.0006	0.0041	0.0117
Brugia malayi	MH1 domain containing protein	0.0008	0.0086	0.0247
Brugia malayi	Patched family protein	0.0006	0.0041	0.0117
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0041	0.0117
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0041	0.0117
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0041	0.0117
Mycobacterium tuberculosis	Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA	0.0155	0.3649	1
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0013	0.0202	0.0181
Echinococcus granulosus	mothers against decapentaplegic 5	0.0008	0.0086	0.0065
Brugia malayi	cytoplasmic intermediate filament protein	0.0014	0.0236	0.0676
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0041	0.0117
Echinococcus multilocularis	cpg binding protein	0.0031	0.0643	0.0623
Brugia malayi	4-aminobutyrate aminotransferase, mitochondrial precursor	0.0022	0.0427	0.1223
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0041	0.0117
Loa Loa (eye worm)	hypothetical protein	0.0053	0.1172	0.3355
Brugia malayi	Smad1	0.0008	0.0086	0.0247
Brugia malayi	MH2 domain containing protein	0.0008	0.0086	0.0247
Schistosoma mansoni	hypothetical protein	0.0042	0.09	0.088
Loa Loa (eye worm)	histone methyltransferase	0.0009	0.0113	0.0323
Loa Loa (eye worm)	patched family protein	0.0006	0.0041	0.0117
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0041	0.0117
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0022	0.0063
Schistosoma mansoni	smad	0.0008	0.0086	0.0065
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0041	0.0117
Schistosoma mansoni	Smad4	0.0008	0.0086	0.0065
Brugia malayi	Patched family protein	0.0006	0.0041	0.0117
Schistosoma mansoni	lamin	0.0026	0.0533	0.0513
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0044	0.0952	0.0932
Echinococcus multilocularis	musashi	0.0026	0.0533	0.0513
Brugia malayi	Patched related family protein 10	0.0006	0.0041	0.0117
Loa Loa (eye worm)	transcription factor SMAD2	0.0117	0.2728	0.7807
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0937	0.2682
Schistosoma mansoni	smad1 5 8 and	0.0008	0.0086	0.0065
Brugia malayi	Patched family protein	0.0006	0.0041	0.0117
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0041	0.0117
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0009	0.0113	0.0091
Loa Loa (eye worm)	patched family protein	0.0006	0.0041	0.0117
Schistosoma mansoni	ornithine--oxo-acid transaminase	0.0022	0.0427	0.0406
Brugia malayi	Patched related family protein 12	0.0006	0.0041	0.0117
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0522	0.1493
Trichomonas vaginalis	acetylornithine aminotransferase, putative	0.0155	0.3649	1
Brugia malayi	hypothetical protein	0.0006	0.0041	0.0117
Plasmodium falciparum	histone acetyltransferase GCN5	0.004	0.0864	1
Loa Loa (eye worm)	acetyltransferase	0.0149	0.3494	1
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0041	0.0117
Echinococcus multilocularis	geminin	0.0173	0.408	0.4067
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0007	0.0069	0.0048
Echinococcus granulosus	Smad4	0.0008	0.0086	0.0065
Echinococcus multilocularis	Niemann Pick C1 protein	0.0144	0.337	0.3355
Onchocerca volvulus		0.0026	0.0533	0.8766
Trichomonas vaginalis	cat eye syndrome critical region protein 2, cscr2, putative	0.0044	0.0952	0.2498
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0041	0.0117
Schistosoma mansoni	cpg binding protein	0.0031	0.0643	0.0623
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0041	0.0117
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0041	0.0117
Echinococcus granulosus	Niemann Pick C1 protein	0.01	0.2326	0.2309
Loa Loa (eye worm)	patched family protein	0.0006	0.0041	0.0117
Schistosoma mansoni	cpg binding protein	0.0029	0.0603	0.0582
Loa Loa (eye worm)	patched family protein	0.0006	0.0041	0.0117
Brugia malayi	Patched family protein	0.0006	0.0041	0.0117
Echinococcus granulosus	cpg binding protein	0.0031	0.0643	0.0623
Brugia malayi	protein C24B5.3	0.0006	0.0041	0.0117
Brugia malayi	MH2 domain containing protein	0.0008	0.0086	0.0247
Echinococcus granulosus	lamin	0.0026	0.0533	0.0513
Echinococcus granulosus	ornithine aminotransferase	0.0022	0.0427	0.0406
Brugia malayi	Niemann-Pick C1 protein precursor	0.01	0.2326	0.6657
Brugia malayi	Patched family protein	0.0006	0.0041	0.0117
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0041	0.0117
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0041	0.0117
Schistosoma mansoni	patched 1	0.0043	0.0937	0.0917
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0007	0.0069	0.0048

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 652897