Detailed information for compound 658388

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 347.195 | Formula: C17H12Cl2N2O2
  • H donors: 1 H acceptors: 2 LogP: 5.23 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(cc1)c1oc(c(n1)C=Nc1cc(Cl)ccc1C)O
  • InChi: 1S/C17H12Cl2N2O2/c1-10-2-5-13(19)8-14(10)20-9-15-17(22)23-16(21-15)11-3-6-12(18)7-4-11/h2-9,22H,1H3
  • InChiKey: JIWICQZKBJIMFL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0111 0.0209
Loa Loa (eye worm) hypothetical protein 0.0025 0.0192 0.0326
Schistosoma mansoni glutaminase 0.0267 0.4404 0.8304
Toxoplasma gondii carbamoylphosphate synthetase 0.0032 0.0313 0.0522
Trypanosoma brucei 6-phosphofructo-2-kinase 2 0.0057 0.0752 0.1419
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0318 0.5299 1
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0097 0.0147
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0058 0.077 0.1421
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0318 0.5299 1
Entamoeba histolytica acyl-coA synthetase, putative 0.0025 0.0192 0.0096
Plasmodium vivax enoyl-acyl carrier protein reductase 0.0183 0.2937 0.5474
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0063 0.0048
Mycobacterium ulcerans aldehyde dehydrogenase 0.0122 0.1883 0.3506
Mycobacterium ulcerans aldehyde dehydrogenase 0.0122 0.1883 0.3506
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0033 0.0326 0.0581
Mycobacterium ulcerans hypothetical protein 0.0025 0.0192 0.0292
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.0318 0.5299 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0141 0.2202 0.4134
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0058 0.077 0.1391
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.0593 0.1086
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0111 0.0013
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0192 0.0292
Loa Loa (eye worm) hypothetical protein 0.0128 0.1989 0.373
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0287 0.4759 0.8943
Brugia malayi glutaminase DH11.1 0.0267 0.4404 0.8304
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0019 0.0081 0.0082
Wolbachia endosymbiont of Brugia malayi enoyl-ACP reductase 0.0183 0.2937 0.7182
Entamoeba histolytica hypothetical protein 0.007 0.0972 0.0883
Mycobacterium leprae Probable bifunctional purine biosynthesis protein PurH : phosphoribosylaminoimidazolecarboxamide formyltransferase (aicar transf 0.0247 0.4052 0.7558
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0589 1 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.0326 0.0581
Loa Loa (eye worm) hypothetical protein 0.0019 0.0081 0.0117
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.007 0.0972 0.1803
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0192 0.0326
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0589 1 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0097 0.0147
Echinococcus granulosus dna polymerase eta 0.002 0.0111 0.0172
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0111 0.0209
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0033 0.0326 0.0548
Mycobacterium tuberculosis Probable bifunctional purine biosynthesis protein PurH: phosphoribosylaminoimidazolecarboxamide formyltransferase (AICAR transfo 0.0247 0.4052 0.7629
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.0593 0.1086
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0025 0.0192 0.0292
Loa Loa (eye worm) hypothetical protein 0.0019 0.0081 0.0117
Echinococcus multilocularis geminin 0.0186 0.3001 0.5647
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.002 0.0097 0.0112
Schistosoma mansoni DNA polymerase eta 0.002 0.0111 0.0172
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0111 0.0013
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0097 0.0147
Brugia malayi hypothetical protein 0.007 0.0972 0.1803
Onchocerca volvulus 0.0058 0.0769 0.139
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0229 0.3742 0.7051
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0033 0.0326 0.0581
Entamoeba histolytica hypothetical protein 0.007 0.0972 0.0883
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0058 0.077 0.1391
Brugia malayi Pre-SET motif family protein 0.0033 0.0326 0.0581
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0097 0.0031
Loa Loa (eye worm) thymidylate synthase 0.0318 0.5299 1
Trypanosoma cruzi 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.0058 0.0769 0.139
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0141 0.2202 0.4134
Mycobacterium ulcerans enoyl-(acyl carrier protein) reductase 0.0183 0.2937 0.5511
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0192 0.0096
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0058 0.077 0.1421
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0033 0.0326 0.0581
Mycobacterium leprae NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) 0.0183 0.2937 0.5376
Wolbachia endosymbiont of Brugia malayi AICAR transformylase/IMP cyclohydrolase PurH 0.0247 0.4052 1
Mycobacterium ulcerans fructose-2,6-bisphosphatase GpmB 0.0034 0.0353 0.0599
Schistosoma mansoni aldehyde dehydrogenase 0.0122 0.1883 0.3529
Giardia lamblia DINP protein human, muc B family 0.002 0.0111 0.0013
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0287 0.4759 0.8974
Giardia lamblia Hypothetical protein 0.0034 0.0353 0.0259
Leishmania major 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.0058 0.0769 0.139
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0122 0.1883 0.3506
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0141 0.2202 0.4134
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0192 0.0326
Entamoeba histolytica hypothetical protein 0.007 0.0972 0.0883
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0318 0.5299 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0063 0.0048
Plasmodium vivax carbamoyl phosphate synthetase, putative 0.0032 0.0313 0.0444
Echinococcus granulosus 6 phosphofructo 2 kinase:fructose 2 0.0058 0.0769 0.142
Toxoplasma gondii enoyl-acyl carrier reductase ENR 0.0183 0.2937 0.5511
Schistosoma mansoni ap endonuclease 0.002 0.0097 0.0147
Plasmodium vivax SET domain protein, putative 0.0033 0.0326 0.0469
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0111 0.0209
Loa Loa (eye worm) hypothetical protein 0.0128 0.1989 0.373
Echinococcus multilocularis dna polymerase eta 0.002 0.0111 0.0172
Trichomonas vaginalis set domain proteins, putative 0.0261 0.4293 0.4237
Echinococcus granulosus thymidylate synthase 0.0318 0.5299 1
Giardia lamblia Hypothetical protein 0.0034 0.0353 0.0259
Brugia malayi hypothetical protein 0.0128 0.1989 0.373
Trypanosoma brucei 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.0025 0.0187 0.0354
Loa Loa (eye worm) glutaminase 2 0.0267 0.4404 0.8304
Onchocerca volvulus Huntingtin homolog 0.0128 0.1989 0.3707
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0122 0.1883 0.3506
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0025 0.0192 0.0292
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0589 1 1
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0025 0.0192 0.0292
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0097 0.0112
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0111 0.0209
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0192 0.0292
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0111 0.0137
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0111 0.0209
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0589 1 1
Plasmodium falciparum enoyl-acyl carrier reductase 0.0183 0.2937 0.5474
Schistosoma mansoni hypothetical protein 0.0186 0.3001 0.5647
Loa Loa (eye worm) hypothetical protein 0.0019 0.0081 0.0117
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0111 0.0209
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0192 0.0292
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0141 0.2202 0.4134
Onchocerca volvulus 0.0261 0.4293 0.8088
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0111 0.0209
Giardia lamblia Fructose-bisphosphate aldolase 0.0589 1 1
Plasmodium falciparum carbamoyl phosphate synthetase 0.0032 0.0313 0.0444
Schistosoma mansoni 6-phosphofructokinase 0.0058 0.0769 0.142
Loa Loa (eye worm) hypothetical protein 0.0033 0.0336 0.06
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0192 0.0292
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0141 0.2202 0.4134
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.0111 0.0137
Brugia malayi hypothetical protein 0.0152 0.2392 0.4494
Wolbachia endosymbiont of Brugia malayi carbamoyl phosphate synthase large subunit 0.0032 0.0313 0.0545
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0032 0.0305 0.0541
Brugia malayi Pre-SET motif family protein 0.0229 0.3742 0.7051
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0097 0.0112
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0111 0.0209
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0058 0.077 0.1391
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0097 0.0184
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0318 0.5299 1
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0287 0.4759 0.8974
Onchocerca volvulus 0.0318 0.5299 1
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0111 0.0172
Schistosoma mansoni aspartate carbamoyltransferase 0.0032 0.0313 0.0556
Leishmania major 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase-1-like protein 0.0025 0.0187 0.0284
Entamoeba histolytica deoxycytidyl transferase, putative 0.002 0.0111 0.0013
Trichomonas vaginalis hypothetical protein 0.0183 0.2937 0.2868
Schistosoma mansoni ap endonuclease 0.002 0.0097 0.0147
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0111 0.0137
Toxoplasma gondii exonuclease III APE 0.002 0.0097 0.0112
Mycobacterium ulcerans thymidylate synthase 0.0318 0.5299 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0326 0.0581
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0111 0.0209
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0111 0.0137
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0097 0.0031
Echinococcus granulosus histone lysine methyltransferase setb 0.0033 0.0326 0.0581
Trypanosoma brucei 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.0058 0.0769 0.1452
Loa Loa (eye worm) hypothetical protein 0.0058 0.0769 0.142
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0025 0.0192 0.0292
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0111 0.0137
Trypanosoma cruzi 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.0025 0.0187 0.0284
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0589 1 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0141 0.2202 0.4134
Echinococcus multilocularis dna polymerase kappa 0.002 0.0111 0.0172
Schistosoma mansoni transcription factor LCR-F1 0.007 0.0972 0.1803
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0058 0.077 0.1421
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0063 0.0048
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.007 0.0972 0.1803
Mycobacterium ulcerans carbamoyl phosphate synthase large subunit 0.0032 0.0313 0.0522
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.0318 0.5299 1
Onchocerca volvulus 0.0025 0.0192 0.0292
Entamoeba histolytica phosphoglycerate mutase family protein, putative 0.0034 0.0353 0.0259
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0097 0.0112
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0326 0.0581
Loa Loa (eye worm) hypothetical protein 0.0048 0.0593 0.1086
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0589 1 1
Chlamydia trachomatis enoyl-acyl-carrier protein reductase 0.0183 0.2937 1
Brugia malayi Cytochrome P450 family protein 0.0069 0.0953 0.1769
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0111 0.0209
Echinococcus multilocularis 6 phosphofructo 2 kinase:fructose 2 0.0058 0.0769 0.142
Trypanosoma cruzi 6-phosphofructo-2-kinase 1 0.0057 0.0752 0.1357
Leishmania major DNA polymerase kappa, putative 0.002 0.0111 0.0137
Treponema pallidum fructose-bisphosphate aldolase 0.0589 1 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0025 0.0192 0.0292
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0111 0.0172
Onchocerca volvulus 0.0033 0.0326 0.0548
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0111 0.0209
Trichomonas vaginalis conserved hypothetical protein 0.0152 0.2392 0.2317
Loa Loa (eye worm) hypothetical protein 0.0019 0.0081 0.0117
Loa Loa (eye worm) hypothetical protein 0.0033 0.0327 0.0583
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0058 0.077 0.1391
Brugia malayi thymidylate synthase 0.0318 0.5299 1
Mycobacterium ulcerans bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase 0.0247 0.4052 0.7629
Entamoeba histolytica hypothetical protein 0.007 0.0972 0.0883
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0589 1 1
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0318 0.5299 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0111 0.0137
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0327 0.0583
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.0111 0.0209
Trypanosoma cruzi 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.0025 0.0187 0.0284
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0141 0.2202 0.4134
Schistosoma mansoni hypothetical protein 0.007 0.0972 0.1803
Echinococcus multilocularis thymidylate synthase 0.0318 0.5299 1
Mycobacterium tuberculosis NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) 0.0183 0.2937 0.5511
Toxoplasma gondii aldehyde dehydrogenase 0.0122 0.1883 0.3506
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0111 0.0172
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0111 0.0209
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.0593 0.1086
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0111 0.0172
Echinococcus granulosus geminin 0.0186 0.3001 0.5647
Loa Loa (eye worm) hypothetical protein 0.0057 0.0752 0.1388
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0589 1 1
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0025 0.0192 0.0292
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0019 0.0081 0.0082
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0111 0.0172
Trypanosoma cruzi 6-phosphofructo-2-kinase 1 0.0057 0.0752 0.1357
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0192 0.0096
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0111 0.0172
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0097 0.0112
Loa Loa (eye worm) glutaminase 0.0267 0.4404 0.8304
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0067 0.0917 0.17
Loa Loa (eye worm) hypothetical protein 0.0025 0.0192 0.0326
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0063 0.0048
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0111 0.0137
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0111 0.0209
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0111 0.0137
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0192 0.0326
Schistosoma mansoni hypothetical protein 0.0033 0.0327 0.0583
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0192 0.0292
Schistosoma mansoni aldehyde dehydrogenase 0.0122 0.1883 0.3529
Trichomonas vaginalis glutaminase, putative 0.0267 0.4404 0.4349
Mycobacterium tuberculosis Hypothetical protein 0.0152 0.2392 0.4474
Loa Loa (eye worm) hypothetical protein 0.0019 0.0081 0.0117
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0058 0.077 0.1421
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0122 0.1883 0.3529
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0122 0.1883 0.3529
Leishmania major 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.0057 0.0752 0.1357
Leishmania major carbamoyl-phosphate synthase, putative 0.0032 0.0313 0.0522
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0326 0.0581
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.0152 0.2392 0.4474
Mycobacterium ulcerans aldehyde dehydrogenase 0.0122 0.1883 0.3506
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0318 0.5299 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0111 0.0137
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0192 0.0292
Loa Loa (eye worm) hypothetical protein 0.002 0.0111 0.0172
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0097 0.0147
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0111 0.0172
Trypanosoma brucei oxidoreductase-like protein 0.0016 0.0038 0.0072
Echinococcus granulosus dna polymerase kappa 0.002 0.0111 0.0172
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0589 1 1
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.0318 0.5299 1
Trypanosoma brucei unspecified product 0.002 0.0111 0.0209
Leishmania major DNA polymerase eta, putative 0.002 0.0111 0.0137
Onchocerca volvulus Huntingtin homolog 0.0128 0.1989 0.3707
Loa Loa (eye worm) cytochrome P450 family protein 0.0069 0.0953 0.1769
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0141 0.2202 0.4134
Trypanosoma cruzi 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.0058 0.0769 0.139
Mycobacterium ulcerans glutaminase 0.0267 0.4404 0.8298
Mycobacterium ulcerans hypothetical protein 0.0034 0.0353 0.0599
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0111 0.0137
Loa Loa (eye worm) hypothetical protein 0.0025 0.0192 0.0326
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0141 0.2202 0.4134
Schistosoma mansoni hypothetical protein 0.0186 0.3001 0.5647

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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