Detailed information for compound 658388

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 347.195 | Formula: C17H12Cl2N2O2
  • H donors: 1 H acceptors: 2 LogP: 5.23 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(cc1)c1oc(c(n1)C=Nc1cc(Cl)ccc1C)O
  • InChi: 1S/C17H12Cl2N2O2/c1-10-2-5-13(19)8-14(10)20-9-15-17(22)23-16(21-15)11-3-6-12(18)7-4-11/h2-9,22H,1H3
  • InChiKey: JIWICQZKBJIMFL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii exonuclease III APE 0.002 0.0097 0.0112
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0111 0.0137
Loa Loa (eye worm) hypothetical protein 0.0019 0.0081 0.0117
Plasmodium falciparum enoyl-acyl carrier reductase 0.0183 0.2937 0.5474
Onchocerca volvulus 0.0261 0.4293 0.8088
Echinococcus multilocularis thymidylate synthase 0.0318 0.5299 1
Mycobacterium tuberculosis Hypothetical protein 0.0152 0.2392 0.4474
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0033 0.0326 0.0548
Mycobacterium ulcerans glutaminase 0.0267 0.4404 0.8298
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0111 0.0209
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0589 1 1
Loa Loa (eye worm) glutaminase 0.0267 0.4404 0.8304
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0192 0.0292
Trypanosoma cruzi 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.0025 0.0187 0.0284
Loa Loa (eye worm) cytochrome P450 family protein 0.0069 0.0953 0.1769
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0111 0.0209
Entamoeba histolytica hypothetical protein 0.007 0.0972 0.0883
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.0111 0.0209
Echinococcus granulosus dna polymerase eta 0.002 0.0111 0.0172
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0111 0.0209
Trypanosoma cruzi 6-phosphofructo-2-kinase 1 0.0057 0.0752 0.1357
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0192 0.0096
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0122 0.1883 0.3529
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0589 1 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0097 0.0147
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0111 0.0137
Echinococcus multilocularis 6 phosphofructo 2 kinase:fructose 2 0.0058 0.0769 0.142
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0111 0.0172
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0067 0.0917 0.17
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0192 0.0326
Mycobacterium ulcerans hypothetical protein 0.0034 0.0353 0.0599
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0192 0.0326
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0192 0.0292
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0192 0.0292
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0141 0.2202 0.4134
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0287 0.4759 0.8974
Giardia lamblia Hypothetical protein 0.0034 0.0353 0.0259
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0025 0.0192 0.0292
Onchocerca volvulus 0.0058 0.0769 0.139
Schistosoma mansoni transcription factor LCR-F1 0.007 0.0972 0.1803
Plasmodium falciparum carbamoyl phosphate synthetase 0.0032 0.0313 0.0444
Entamoeba histolytica hypothetical protein 0.007 0.0972 0.0883
Trichomonas vaginalis hypothetical protein 0.0183 0.2937 0.2868
Mycobacterium ulcerans carbamoyl phosphate synthase large subunit 0.0032 0.0313 0.0522
Echinococcus multilocularis geminin 0.0186 0.3001 0.5647
Loa Loa (eye worm) glutaminase 2 0.0267 0.4404 0.8304
Giardia lamblia Fructose-bisphosphate aldolase 0.0589 1 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0141 0.2202 0.4134
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0058 0.077 0.1421
Entamoeba histolytica deoxycytidyl transferase, putative 0.002 0.0111 0.0013
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0141 0.2202 0.4134
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0097 0.0147
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.0593 0.1086
Entamoeba histolytica hypothetical protein 0.007 0.0972 0.0883
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0111 0.0172
Leishmania major DNA polymerase kappa, putative 0.002 0.0111 0.0137
Toxoplasma gondii aldehyde dehydrogenase 0.0122 0.1883 0.3506
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0589 1 1
Schistosoma mansoni aldehyde dehydrogenase 0.0122 0.1883 0.3529
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0229 0.3742 0.7051
Onchocerca volvulus 0.0025 0.0192 0.0292
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0318 0.5299 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0097 0.0112
Trypanosoma brucei 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.0025 0.0187 0.0354
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0063 0.0048
Echinococcus granulosus dna polymerase kappa 0.002 0.0111 0.0172
Schistosoma mansoni aspartate carbamoyltransferase 0.0032 0.0313 0.0556
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.007 0.0972 0.1803
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0097 0.0112
Mycobacterium tuberculosis NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) 0.0183 0.2937 0.5511
Loa Loa (eye worm) hypothetical protein 0.0048 0.0593 0.1086
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0122 0.1883 0.3506
Onchocerca volvulus Huntingtin homolog 0.0128 0.1989 0.3707
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0122 0.1883 0.3529
Trichomonas vaginalis glutaminase, putative 0.0267 0.4404 0.4349
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0318 0.5299 1
Mycobacterium ulcerans enoyl-(acyl carrier protein) reductase 0.0183 0.2937 0.5511
Giardia lamblia Hypothetical protein 0.0034 0.0353 0.0259
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0589 1 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0122 0.1883 0.3506
Echinococcus granulosus thymidylate synthase 0.0318 0.5299 1
Entamoeba histolytica phosphoglycerate mutase family protein, putative 0.0034 0.0353 0.0259
Toxoplasma gondii enoyl-acyl carrier reductase ENR 0.0183 0.2937 0.5511
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0111 0.0209
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0111 0.0137
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.0111 0.0137
Trypanosoma brucei 6-phosphofructo-2-kinase 2 0.0057 0.0752 0.1419
Brugia malayi hypothetical protein 0.0128 0.1989 0.373
Trichomonas vaginalis set domain proteins, putative 0.0261 0.4293 0.4237
Trypanosoma cruzi 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.0058 0.0769 0.139
Onchocerca volvulus Huntingtin homolog 0.0128 0.1989 0.3707
Onchocerca volvulus 0.0033 0.0326 0.0548
Trypanosoma brucei 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.0058 0.0769 0.1452
Trypanosoma cruzi 6-phosphofructo-2-kinase 1 0.0057 0.0752 0.1357
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.0593 0.1086
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0033 0.0326 0.0581
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0111 0.0137
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0058 0.077 0.1391
Trypanosoma cruzi 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.0025 0.0187 0.0284
Loa Loa (eye worm) hypothetical protein 0.0019 0.0081 0.0117
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0111 0.0209
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0141 0.2202 0.4134
Loa Loa (eye worm) hypothetical protein 0.0025 0.0192 0.0326
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0063 0.0048
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0122 0.1883 0.3506
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0192 0.0096
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0111 0.0209
Brugia malayi hypothetical protein 0.0152 0.2392 0.4494
Plasmodium vivax enoyl-acyl carrier protein reductase 0.0183 0.2937 0.5474
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0058 0.077 0.1421
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0318 0.5299 1
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0111 0.0209
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0097 0.0031
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0025 0.0192 0.0292
Leishmania major 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.0057 0.0752 0.1357
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0058 0.077 0.1421
Echinococcus granulosus geminin 0.0186 0.3001 0.5647
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0111 0.0137
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0111 0.0172
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0033 0.0326 0.0581
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0318 0.5299 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0081 0.0117
Echinococcus granulosus histone lysine methyltransferase setb 0.0033 0.0326 0.0581
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0287 0.4759 0.8943
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0141 0.2202 0.4134
Wolbachia endosymbiont of Brugia malayi AICAR transformylase/IMP cyclohydrolase PurH 0.0247 0.4052 1
Loa Loa (eye worm) hypothetical protein 0.0128 0.1989 0.373
Loa Loa (eye worm) hypothetical protein 0.0019 0.0081 0.0117
Loa Loa (eye worm) hypothetical protein 0.0128 0.1989 0.373
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.0318 0.5299 1
Brugia malayi Cytochrome P450 family protein 0.0069 0.0953 0.1769
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0025 0.0192 0.0292
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0111 0.0137
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0097 0.0031
Loa Loa (eye worm) hypothetical protein 0.0019 0.0081 0.0117
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0141 0.2202 0.4134
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0063 0.0048
Leishmania major DNA polymerase eta, putative 0.002 0.0111 0.0137
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0111 0.0209
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0032 0.0305 0.0541
Mycobacterium ulcerans hypothetical protein 0.0025 0.0192 0.0292
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0141 0.2202 0.4134
Mycobacterium ulcerans thymidylate synthase 0.0318 0.5299 1
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0033 0.0326 0.0581
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0019 0.0081 0.0082
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0192 0.0292
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0025 0.0192 0.0292
Mycobacterium ulcerans aldehyde dehydrogenase 0.0122 0.1883 0.3506
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0025 0.0192 0.0292
Trypanosoma brucei unspecified product 0.002 0.0111 0.0209
Trypanosoma brucei oxidoreductase-like protein 0.0016 0.0038 0.0072
Echinococcus granulosus 6 phosphofructo 2 kinase:fructose 2 0.0058 0.0769 0.142
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0111 0.0172
Loa Loa (eye worm) hypothetical protein 0.0025 0.0192 0.0326
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0318 0.5299 1
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0097 0.0112
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0111 0.0209
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0111 0.0137
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0111 0.0172
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.0593 0.1086
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0141 0.2202 0.4134
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.002 0.0097 0.0112
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0111 0.0137
Toxoplasma gondii carbamoylphosphate synthetase 0.0032 0.0313 0.0522
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0111 0.0013
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0097 0.0147
Mycobacterium leprae Probable bifunctional purine biosynthesis protein PurH : phosphoribosylaminoimidazolecarboxamide formyltransferase (aicar transf 0.0247 0.4052 0.7558
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0326 0.0581
Entamoeba histolytica hypothetical protein 0.007 0.0972 0.0883
Brugia malayi thymidylate synthase 0.0318 0.5299 1
Wolbachia endosymbiont of Brugia malayi carbamoyl phosphate synthase large subunit 0.0032 0.0313 0.0545
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0058 0.077 0.1391
Mycobacterium ulcerans bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase 0.0247 0.4052 0.7629
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0111 0.0209
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0192 0.0292
Brugia malayi glutaminase DH11.1 0.0267 0.4404 0.8304
Loa Loa (eye worm) hypothetical protein 0.0033 0.0327 0.0583
Schistosoma mansoni hypothetical protein 0.0186 0.3001 0.5647
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0111 0.0209
Entamoeba histolytica acyl-coA synthetase, putative 0.0025 0.0192 0.0096
Loa Loa (eye worm) hypothetical protein 0.0058 0.0769 0.142
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.0318 0.5299 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0589 1 1
Schistosoma mansoni hypothetical protein 0.007 0.0972 0.1803
Chlamydia trachomatis enoyl-acyl-carrier protein reductase 0.0183 0.2937 1
Leishmania major carbamoyl-phosphate synthase, putative 0.0032 0.0313 0.0522
Brugia malayi hypothetical protein 0.007 0.0972 0.1803
Wolbachia endosymbiont of Brugia malayi enoyl-ACP reductase 0.0183 0.2937 0.7182
Schistosoma mansoni aldehyde dehydrogenase 0.0122 0.1883 0.3529
Leishmania major 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase-1-like protein 0.0025 0.0187 0.0284
Trypanosoma cruzi 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.0058 0.0769 0.139
Schistosoma mansoni glutaminase 0.0267 0.4404 0.8304
Loa Loa (eye worm) thymidylate synthase 0.0318 0.5299 1
Brugia malayi Pre-SET motif family protein 0.0033 0.0326 0.0581
Leishmania major 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.0058 0.0769 0.139
Loa Loa (eye worm) hypothetical protein 0.0057 0.0752 0.1388
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0326 0.0581
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0097 0.0112
Loa Loa (eye worm) hypothetical protein 0.002 0.0111 0.0172
Plasmodium vivax carbamoyl phosphate synthetase, putative 0.0032 0.0313 0.0444
Trichomonas vaginalis conserved hypothetical protein 0.0152 0.2392 0.2317
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0097 0.0184
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0192 0.0326
Loa Loa (eye worm) hypothetical protein 0.0025 0.0192 0.0326
Schistosoma mansoni DNA polymerase eta 0.002 0.0111 0.0172
Treponema pallidum fructose-bisphosphate aldolase 0.0589 1 1
Mycobacterium leprae NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) 0.0183 0.2937 0.5376
Mycobacterium ulcerans fructose-2,6-bisphosphatase GpmB 0.0034 0.0353 0.0599
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0111 0.0209
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0589 1 1
Echinococcus multilocularis dna polymerase eta 0.002 0.0111 0.0172
Loa Loa (eye worm) hypothetical protein 0.0033 0.0336 0.06
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0326 0.0581
Mycobacterium ulcerans aldehyde dehydrogenase 0.0122 0.1883 0.3506
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0327 0.0583
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0589 1 1
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0111 0.0172
Schistosoma mansoni hypothetical protein 0.0186 0.3001 0.5647
Giardia lamblia DINP protein human, muc B family 0.002 0.0111 0.0013
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0589 1 1
Schistosoma mansoni ap endonuclease 0.002 0.0097 0.0147
Schistosoma mansoni ap endonuclease 0.002 0.0097 0.0147
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.007 0.0972 0.1803
Brugia malayi Pre-SET motif family protein 0.0229 0.3742 0.7051
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0192 0.0292
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0589 1 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0111 0.0137
Schistosoma mansoni hypothetical protein 0.0033 0.0327 0.0583
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0287 0.4759 0.8974
Mycobacterium tuberculosis Probable bifunctional purine biosynthesis protein PurH: phosphoribosylaminoimidazolecarboxamide formyltransferase (AICAR transfo 0.0247 0.4052 0.7629
Loa Loa (eye worm) hypothetical protein 0.0033 0.0326 0.0581
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.0152 0.2392 0.4474
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0063 0.0048
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0111 0.0013
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0318 0.5299 1
Schistosoma mansoni 6-phosphofructokinase 0.0058 0.0769 0.142
Echinococcus multilocularis dna polymerase kappa 0.002 0.0111 0.0172
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0019 0.0081 0.0082
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0058 0.077 0.1391
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0058 0.077 0.1391
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.0318 0.5299 1
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0111 0.0172
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0141 0.2202 0.4134
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0025 0.0192 0.0292
Plasmodium vivax SET domain protein, putative 0.0033 0.0326 0.0469
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0111 0.0209
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0058 0.077 0.1421
Onchocerca volvulus 0.0318 0.5299 1
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0097 0.0147

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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