Detailed information for compound 658809

Basic information

Technical information
  • TDR Targets ID: 658809
  • Name: (4Z)-2-(4-chloro-3-nitrophenyl)-4-(furan-2-yl methylidene)-1,3-oxazol-5-one
  • MW: 318.669 | Formula: C14H7ClN2O5
  • H donors: 0 H acceptors: 3 LogP: 3.12 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1OC(=NC1=Cc1ccco1)c1ccc(c(c1)[N+](=O)[O-])Cl
  • InChi: 1S/C14H7ClN2O5/c15-10-4-3-8(6-12(10)17(19)20)13-16-11(14(18)22-13)7-9-2-1-5-21-9/h1-7H/b11-7-
  • InChiKey: RKVLTVCHYJZUNE-XFFZJAGNSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-(4-chloro-3-nitrophenyl)-4-(furan-2-ylmethylidene)-1,3-oxazol-5-one
  • 2-(4-chloro-3-nitro-phenyl)-4-(2-furylmethylene)oxazol-5-one
  • (4Z)-2-(4-chloro-3-nitro-phenyl)-4-(2-furylmethylene)oxazol-5-one
  • 2-(4-chloro-3-nitrophenyl)-4-(2-furylmethylene)-5-oxazolone
  • (4Z)-2-(4-chloro-3-nitrophenyl)-4-(2-furylmethylene)-5-oxazolone
  • 2-(4-chloro-3-nitro-phenyl)-4-(furan-2-ylmethylidene)-1,3-oxazol-5-one
  • (4Z)-2-(4-chloro-3-nitro-phenyl)-4-(furan-2-ylmethylidene)-1,3-oxazol-5-one
  • ST000439
  • 2-(4-Chloro-3-nitro-phenyl)-4-furan-2-ylmethylene-4H-oxazol-5-one
  • BAS 00367684
  • ZINC00027686

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus geminin 0.0166 0.1796 0.4978
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0049 0.0383 0.1142
Echinococcus granulosus GPCR family 2 0.0033 0.0183 0.0506
Trichomonas vaginalis ran, putative 0.0022 0.0052 0.0087
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0033 0.0183 0.051
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.008 0.0759 1
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0023 0.0068 0.0189
Brugia malayi Bromodomain containing protein 0.0039 0.0264 0.0766
Schistosoma mansoni hypothetical protein 0.0033 0.0183 0.0506
Loa Loa (eye worm) MH2 domain-containing protein 0.0242 0.2721 0.7541
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0586 0.1624
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0103 0.1035 0.2868
Brugia malayi latrophilin 2 splice variant baaae 0.007 0.064 0.1958
Schistosoma mansoni hypothetical protein 0.0021 0.0044 0.0123
Echinococcus multilocularis geminin 0.0166 0.1796 0.1796
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0023 0.0068 0.0068
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.0052 0.0407
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0066 0.0586 0.1624
Brugia malayi PHD-finger family protein 0.0026 0.0098 0.024
Plasmodium falciparum ornithine aminotransferase 0.0043 0.0311 0.3919
Schistosoma mansoni hypothetical protein 0.007 0.064 0.1775
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0052 0.5279
Brugia malayi RNA recognition motif domain containing protein 0.0066 0.0586 0.1786
Schistosoma mansoni ap endonuclease 0.0019 0.0022 0.006
Mycobacterium ulcerans 4-aminobutyrate aminotransferase 0.0043 0.0311 0.084
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0061 0.0529 0.0529
Plasmodium falciparum importin beta, putative 0.003 0.0146 0.1688
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.033 0.0916
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0022 0.006
Mycobacterium ulcerans adenosylmethionine-8-amino-7-oxononanoate aminotransferase 0.0303 0.3462 1
Brugia malayi Importin beta-1 subunit 0.003 0.0146 0.0394
Trichomonas vaginalis glutaminase, putative 0.028 0.3181 0.9182
Brugia malayi Bromodomain containing protein 0.0077 0.0719 0.2207
Schistosoma mansoni hypothetical protein 0.0033 0.0183 0.0506
Mycobacterium ulcerans hypothetical protein 0.0303 0.3462 1
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0022 0.0052 1
Mycobacterium tuberculosis Probable ornithine aminotransferase (N-terminus part) RocD1 (ornithine--oxo-acid aminotransferase) 0.0043 0.0311 0.084
Entamoeba histolytica hypothetical protein 0.0024 0.0079 1
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0037 0.0234 0.0649
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0053 0.0425 0.1171
Brugia malayi RNA binding protein 0.0066 0.0586 0.1786
Schistosoma mansoni peptidase Clp (S14 family) 0.008 0.0759 0.2103
Loa Loa (eye worm) bromodomain containing protein 0.0018 0.0008 0.0021
Brugia malayi hypothetical protein 0.024 0.2701 0.8482
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0052 0.0143
Brugia malayi Latrophilin receptor protein 2 0.0033 0.0183 0.051
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.008 0.0759 1
Loa Loa (eye worm) hypothetical protein 0.0044 0.0318 0.088
Loa Loa (eye worm) hypothetical protein 0.007 0.064 0.1775
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0022 0.0022
Schistosoma mansoni hypothetical protein 0.0049 0.0383 0.106
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0079 0.0165
Brugia malayi Muscleblind-like protein 0.0153 0.1642 0.5129
Echinococcus granulosus Aminotransferase class III 0.0043 0.0311 0.0861
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0037 0.0234 0.0234
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.008 0.0759 0.2142
Mycobacterium ulcerans 4-aminobutyrate aminotransferase 0.0043 0.0311 0.084
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0146 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.0294 0.0815
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.033 0.0977
Toxoplasma gondii ornithine aminotransferase, mitochondrial precursor, putative 0.0043 0.0311 0.3919
Echinococcus multilocularis ornithine aminotransferase 0.0043 0.0311 0.0311
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.0146 0.1688
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0052 0.0095
Schistosoma mansoni importin beta-1 0.003 0.0146 0.0405
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0033 0.0183 0.0183
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0022 0.006
Echinococcus multilocularis Aminotransferase class III 0.0043 0.0311 0.0311
Mycobacterium tuberculosis Probable glutamate-1-semialdehyde 2,1-aminomutase HemL (GSA) (glutamate-1-semialdehyde aminotransferase) (GSA-at) 0.0043 0.0311 0.084
Mycobacterium ulcerans glutaminase 0.028 0.3181 0.9182
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.033 0.0916
Mycobacterium ulcerans ornithine aminotransferase RocD1 and RocD2 0.0043 0.0311 0.084
Brugia malayi TAR-binding protein 0.0066 0.0586 0.1786
Echinococcus granulosus survival motor neuron protein 1 0.024 0.2701 0.7486
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.033 0.0916
Loa Loa (eye worm) hypothetical protein 0.0033 0.0183 0.0506
Echinococcus granulosus importin subunit beta 1 0.003 0.0146 0.0405
Mycobacterium ulcerans L-lysine aminotransferase 0.0043 0.0311 0.084
Echinococcus multilocularis muscleblind protein 0.0153 0.1642 0.1642
Brugia malayi MH2 domain containing protein 0.0242 0.2721 0.8545
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.0052 0.0407
Schistosoma mansoni survival motor neuron protein 0.0049 0.0383 0.106
Mycobacterium leprae PROBABLE GLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE HEML (GSA) (GLUTAMATE-1-SEMIALDEHYDE AMINOTRANSFERASE) (GSA-AT) 0.0043 0.0311 0.0563
Echinococcus granulosus tar DNA binding protein 0.0066 0.0586 0.1624
Schistosoma mansoni glutaminase 0.028 0.3181 0.8815
Brugia malayi Calcitonin receptor-like protein seb-1 0.0103 0.1035 0.3207
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.008 0.0759 1
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0053 0.0425 0.1171
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.008 0.0759 0.1905
Schistosoma mansoni hypothetical protein 0.0033 0.0183 0.0506
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.008 0.0759 1
Loa Loa (eye worm) transcription factor SMAD2 0.0242 0.2721 0.7541
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0033 0.0183 0.0183
Echinococcus multilocularis importin subunit beta 1 0.003 0.0146 0.0146
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0146 1
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.008 0.0759 0.2142
Plasmodium vivax ornithine aminotransferase, putative 0.0043 0.0311 0.3919
Echinococcus granulosus snurportin 1 0.0315 0.3609 1
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0052 0.0052
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0586 0.1624
Schistosoma mansoni hypothetical protein 0.0315 0.3609 1
Mycobacterium tuberculosis Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA 0.0303 0.3462 1
Brugia malayi 4-aminobutyrate aminotransferase, mitochondrial precursor 0.0043 0.0311 0.0915
Schistosoma mansoni ran 0.0022 0.0052 0.0143
Echinococcus granulosus ornithine aminotransferase 0.0043 0.0311 0.0861
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0033 0.0183 0.0506
Loa Loa (eye worm) glutaminase 0.028 0.3181 0.8815
Echinococcus multilocularis tar DNA binding protein 0.0066 0.0586 0.0586
Loa Loa (eye worm) hypothetical protein 0.003 0.0146 0.0405
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.033 0.0916
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0028 0.0123 0.137
Schistosoma mansoni ran 0.0022 0.0052 0.0143
Mycobacterium leprae Probable Acetylornithine aminotransferase ArgD 0.0043 0.0311 0.0563
Mycobacterium tuberculosis Probable L-lysine-epsilon aminotransferase Lat (L-lysine aminotransferase) (lysine 6-aminotransferase) 0.0043 0.0311 0.084
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.0044 0.0123
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0028 0.0123 0.137
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.0052 0.2408
Echinococcus multilocularis zinc finger protein 0.002 0.0031 0.0031
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0061 0.0529 0.1467
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0033 0.0183 0.0506
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.008 0.0759 0.2103
Brugia malayi RNA, U transporter 1 0.0084 0.0806 0.2482
Schistosoma mansoni bromodomain containing protein 0.0065 0.0574 0.159
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.033 0.0916
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.033 0.033
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0315 0.3609 1
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0586 0.1624
Loa Loa (eye worm) glutaminase 2 0.028 0.3181 0.8815
Loa Loa (eye worm) hypothetical protein 0.0153 0.1642 0.4551
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0053 0.0425 0.0904
Loa Loa (eye worm) hypothetical protein 0.0072 0.0666 0.1846
Echinococcus multilocularis survival motor neuron protein 1 0.024 0.2701 0.2701
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0052 0.5279
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.033 0.033
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0052 0.0143
Echinococcus multilocularis muscleblind protein 1 0.0153 0.1642 0.1642
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0028 0.0123 0.137
Plasmodium vivax importin-beta 2, putative 0.003 0.0146 0.1688
Trichomonas vaginalis acetylornithine aminotransferase, putative 0.0303 0.3462 1
Leishmania major GTP-binding protein, putative 0.0022 0.0052 0.5279
Loa Loa (eye worm) hypothetical protein 0.0103 0.1035 0.2868
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.008 0.0759 1
Wolbachia endosymbiont of Brugia malayi acetylornithine transaminase protein 0.0043 0.0311 0.3919
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.008 0.0759 1
Entamoeba histolytica Ran family GTPase 0.0022 0.0052 0.5279
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.0052 0.0407
Mycobacterium ulcerans acetylornithine aminotransferase 0.0043 0.0311 0.084
Loa Loa (eye worm) hypothetical protein 0.024 0.2701 0.7486
Echinococcus granulosus muscleblind protein 0.0153 0.1642 0.4551
Mycobacterium tuberculosis Probable aminotransferase 0.0303 0.3462 1
Echinococcus granulosus fetal alzheimer antigen falz 0.0023 0.0068 0.0189
Echinococcus multilocularis GPCR, family 2 0.0033 0.0183 0.0183
Loa Loa (eye worm) latrophilin receptor protein 2 0.0033 0.0183 0.0506
Toxoplasma gondii hypothetical protein 0.0028 0.0123 0.137
Mycobacterium ulcerans glutamate-1-semialdehyde aminotransferase 0.0043 0.0311 0.084
Schistosoma mansoni hypothetical protein 0.0166 0.1796 0.4978
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0079 0.0165
Echinococcus granulosus peptidase Clp S14 family 0.0053 0.0425 0.1176
Echinococcus granulosus zinc finger protein 0.002 0.0031 0.0087
Loa Loa (eye worm) hypothetical protein 0.0039 0.0265 0.0733
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0079 0.0165
Schistosoma mansoni ornithine--oxo-acid transaminase 0.0043 0.0311 0.0861
Brugia malayi glutaminase DH11.1 0.028 0.3181 1
Brugia malayi Probable ClpP-like protease 0.008 0.0759 0.2333
Schistosoma mansoni ap endonuclease 0.0019 0.0022 0.006
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0586 0.1624
Echinococcus multilocularis ornithine aminotransferase 0.0043 0.0311 0.0311
Schistosoma mansoni hypothetical protein 0.0166 0.1796 0.4978
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.033 0.0916
Echinococcus multilocularis peptidase Clp (S14 family) 0.0053 0.0425 0.0425
Loa Loa (eye worm) hypothetical protein 0.0153 0.1642 0.4551
Loa Loa (eye worm) hypothetical protein 0.008 0.0759 0.2103
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0079 1
Schistosoma mansoni hypothetical protein 0.0033 0.0183 0.0506
Mycobacterium leprae Probable 4-aminobutyrate aminotransferase GabT (GAMMA-AMINO-N-BUTYRATE TRANSAMINASE) (GABA TRANSAMINASE) (GLUTAMATE:SUCCINIC SEM 0.0043 0.0311 0.0563
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.008 0.0759 0.0759
Mycobacterium leprae PROBABLE ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE BIOA 0.0303 0.3462 1
Schistosoma mansoni zinc finger protein 0.002 0.0031 0.0087
Loa Loa (eye worm) TAR-binding protein 0.0066 0.0586 0.1624
Leishmania major importin beta-1 subunit, putative 0.0024 0.0079 1
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.008 0.0759 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0103 0.1035 0.3207
Echinococcus multilocularis snurportin 1 0.0315 0.3609 0.3609
Loa Loa (eye worm) RNA binding protein 0.0066 0.0586 0.1624
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0586 0.1624
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.008 0.0759 1
Mycobacterium tuberculosis Probable acetylornithine aminotransferase ArgD 0.0043 0.0311 0.084
Onchocerca volvulus 0.0049 0.0383 0.5

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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