TDR Targets

Basic information

Technical information

TDR Targets ID: 661181
Name: N-[1-(4-iodophenyl)ethyl]cyclohexanecarboxami de
MW: 357.23 | Formula: C15H20INO
H donors: 1 H acceptors: 1 LogP: 4.17 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: CC(c1ccc(cc1)I)NC(=O)C1CCCCC1
InChi: 1S/C15H20INO/c1-11(12-7-9-14(16)10-8-12)17-15(18)13-5-3-2-4-6-13/h7-11,13H,2-6H2,1H3,(H,17,18)
InChiKey: VUZWBJVQMZTFKZ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	carboxylesterase 5A	0.013	0.3788	0.3788
Echinococcus granulosus	calpain A	0.0019	0.0309	0.0309
Echinococcus granulosus	methyl CpG binding domain protein 2	0.0017	0.0246	0.0246
Loa Loa (eye worm)	hypothetical protein	0.0063	0.1685	0.4447
Echinococcus multilocularis	calpain 7 (C02 family)	0.0019	0.0309	0.0309
Entamoeba histolytica	hypothetical protein	0.0035	0.0825	1
Schistosoma mansoni	hypothetical protein	0.0015	0.0192	0.0353
Schistosoma mansoni	neuroligin 3 (S09 family)	0.0022	0.0412	0.0758
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0019	0.0309	0.3098
Echinococcus granulosus	family C2 unassigned peptidase C02 family	0.0066	0.1785	0.1785
Plasmodium falciparum	ataxin-2 like protein, putative	0.0027	0.0568	0.5
Brugia malayi	PHD-finger family protein	0.0026	0.0535	0.1413
Loa Loa (eye worm)	hypothetical protein	0.0044	0.1102	0.2908
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0022	0.0412	0.0758
Loa Loa (eye worm)	hypothetical protein	0.0044	0.1102	0.2908
Loa Loa (eye worm)	calpain	0.0019	0.0309	0.0815
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0019	0.0309	0.3098
Loa Loa (eye worm)	transcription factor SMAD2	0.0129	0.375	0.99
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0412	0.1088
Schistosoma mansoni	calpain-7 (C02 family)	0.0019	0.0309	0.0568
Loa Loa (eye worm)	hypothetical protein	0.0086	0.2418	0.6382
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0022	0.0412	0.5
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0019	0.0309	0.3098
Schistosoma mansoni	cpg binding protein	0.0031	0.0709	0.1305
Echinococcus multilocularis	acetylcholinesterase	0.013	0.3788	0.3788
Brugia malayi	hypothetical protein	0.0035	0.0825	0.2177
Echinococcus granulosus	cpg binding protein	0.0031	0.0709	0.0709
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0412	0.1088
Schistosoma mansoni	cellular tumor antigen P53	0.0048	0.123	0.2261
Mycobacterium ulcerans	carboxylesterase, LipT	0.0022	0.0412	0.5
Loa Loa (eye worm)	hypothetical protein	0.0043	0.1076	0.284
Schistosoma mansoni	acetylcholinesterase	0.0022	0.0412	0.0758
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0412	0.1088
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.0024	0.0463	0.0463
Onchocerca volvulus		0.0028	0.0601	0.2314
Entamoeba histolytica	hypothetical protein	0.0035	0.0825	1
Loa Loa (eye worm)	hypothetical protein	0.0048	0.123	0.3246
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0022	0.0412	0.0758
Echinococcus multilocularis	calpain	0.0019	0.0309	0.0309
Brugia malayi	F/Y-rich N-terminus family protein	0.001	0.0051	0.0136
Loa Loa (eye worm)	hypothetical protein	0.0069	0.1882	0.4967
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0412	0.1088
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0019	0.0309	0.3098
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0094	0.2665	0.7035
Schistosoma mansoni	transcription factor LCR-F1	0.0035	0.0825	0.1517
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0022	0.0412	0.0758
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0066	0.1785	0.3282
Loa Loa (eye worm)	calpain 5	0.0019	0.0309	0.0815
Plasmodium vivax	ataxin-2 like protein, putative	0.0027	0.0568	1
Trypanosoma cruzi	PAB1-binding protein , putative	0.0027	0.0568	1
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0022	0.0412	0.5
Brugia malayi	Carboxylesterase family protein	0.0022	0.0412	0.1088
Leishmania major	kinesin, putative	0.0019	0.0309	0.3098
Echinococcus granulosus	fetal alzheimer antigen falz	0.0024	0.0463	0.0463
Brugia malayi	Carboxylesterase family protein	0.0022	0.0412	0.1088
Brugia malayi	Bromodomain containing protein	0.0075	0.2062	0.5443
Schistosoma mansoni	hypothetical protein	0.002	0.0355	0.0652
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0094	0.2665	0.2665
Entamoeba histolytica	hypothetical protein	0.0035	0.0825	1
Echinococcus granulosus	acetylcholinesterase	0.013	0.3788	0.3788
Echinococcus granulosus	geminin	0.0183	0.5438	0.5438
Echinococcus multilocularis	family C2 unassigned peptidase (C02 family)	0.0066	0.1785	0.1785
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0019	0.0309	0.3098
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0019	0.0309	0.3098
Echinococcus multilocularis	BC026374 protein (S09 family)	0.0022	0.0412	0.0412
Trichomonas vaginalis	spcc417.12 protein, putative	0.0022	0.0412	0.5
Schistosoma mansoni	BC026374 protein (S09 family)	0.0022	0.0412	0.0758
Brugia malayi	calpain family protein 1	0.0063	0.1685	0.4447
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0265	0.0699
Schistosoma mansoni	cpg binding protein	0.0031	0.0709	0.1305
Echinococcus multilocularis	hypothetical protein	0.0019	0.0309	0.0309
Schistosoma mansoni	eyes absent homolog	0.0086	0.2418	0.4446
Plasmodium falciparum	ataxin-2 like protein, putative	0.0027	0.0568	0.5
Echinococcus granulosus	family S9 non peptidase ue S09 family	0.0022	0.0412	0.0412
Trypanosoma brucei	calpain-like protein, putative	0.0019	0.0309	0.3098
Schistosoma mansoni	zinc finger protein	0.0015	0.0192	0.0353
Echinococcus granulosus	histone lysine methyltransferase setb	0.0017	0.0265	0.0265
Schistosoma mansoni	Mername-AA248 (C02 family)	0.0019	0.0309	0.0568
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0017	0.0265	0.0265
Trypanosoma brucei	cysteine peptidase, Clan CA, family C2, putative	0.0019	0.0309	0.3098
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0017	0.0265	0.0487
Echinococcus multilocularis	cpg binding protein	0.0031	0.0709	0.0709
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.0012	0.0104	0.0104
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0094	0.2665	0.4901
Trypanosoma cruzi	PAB1-binding protein , putative	0.0027	0.0568	1
Echinococcus granulosus	acetylcholinesterase	0.013	0.3788	0.3788
Brugia malayi	Carboxylesterase family protein	0.013	0.3788	1
Brugia malayi	calpain family protein 1	0.0063	0.1685	0.4447
Echinococcus multilocularis	calpain A	0.0066	0.1785	0.1785
Brugia malayi	hypothetical protein	0.0027	0.0568	0.1499
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.006	0.1596	0.1596
Brugia malayi	hypothetical protein	0.0022	0.0412	0.1088
Loa Loa (eye worm)	carboxylesterase	0.0022	0.0412	0.1088
Echinococcus granulosus	calpain 5	0.0019	0.0309	0.0309
Echinococcus multilocularis	family S9 non peptidase ue (S09 family)	0.0022	0.0412	0.0412
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0094	0.2665	0.2665
Schistosoma mansoni	calpain-7 (C02 family)	0.0019	0.0309	0.0568
Schistosoma mansoni	hypothetical protein	0.0183	0.5438	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0094	0.2665	0.4901
Brugia malayi	Carboxylesterase family protein	0.0022	0.0412	0.1088
Loa Loa (eye worm)	carboxylesterase	0.013	0.3788	1
Loa Loa (eye worm)	MH2 domain-containing protein	0.0129	0.375	0.99
Loa Loa (eye worm)	hypothetical protein	0.004	0.0968	0.2554
Schistosoma mansoni	gliotactin	0.0022	0.0412	0.0758
Loa Loa (eye worm)	hypothetical protein	0.0063	0.1685	0.4447
Echinococcus granulosus	neuroligin	0.0022	0.0412	0.0412
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0035	0.0821	0.0821
Loa Loa (eye worm)	acetylcholinesterase 1	0.013	0.3788	1
Trypanosoma brucei	calpain-like protein, putative	0.0019	0.0309	0.3098
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0035	0.0825	0.0825
Echinococcus multilocularis	acetylcholinesterase	0.013	0.3788	0.3788
Trypanosoma brucei	calpain-like cysteine peptidase, putative	0.0019	0.0309	0.3098
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0019	0.0309	0.3098
Echinococcus granulosus	calpain	0.0019	0.0309	0.0309
Leishmania major	hypothetical protein, conserved	0.0027	0.0568	1
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0094	0.2665	0.7035
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0568	0.1499
Brugia malayi	MH2 domain containing protein	0.0129	0.375	0.99
Echinococcus granulosus	zinc finger protein	0.0021	0.0373	0.0373
Entamoeba histolytica	hypothetical protein	0.0035	0.0825	1
Trichomonas vaginalis	carboxylesterase domain containing protein, putative	0.0022	0.0412	0.5
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.0012	0.0104	0.0104
Schistosoma mansoni	cpg binding protein	0.0028	0.0601	0.1106
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0017	0.0246	0.0452
Schistosoma mansoni	zinc finger protein	0.0021	0.0373	0.0685
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.006	0.1596	0.1596
Trypanosoma cruzi	kinesin, putative	0.0019	0.0309	0.3098
Brugia malayi	CXXC zinc finger family protein	0.0028	0.0601	0.1587
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0035	0.0821	0.0821
Echinococcus granulosus	calpain 7 C02 family	0.0019	0.0309	0.0309
Echinococcus multilocularis	tumor protein p63	0.0329	1	1
Trypanosoma cruzi	kinesin, putative	0.0019	0.0309	0.3098
Echinococcus multilocularis	neuroligin	0.0022	0.0412	0.0412
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0017	0.0246	0.0452
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0019	0.0309	0.3098
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.013	0.3788	0.6966
Mycobacterium tuberculosis	Carboxylesterase LipT	0.0022	0.0412	0.5
Onchocerca volvulus		0.0048	0.123	1
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0066	0.1785	0.3282
Leishmania major	calpain, putative,cysteine peptidase, Clan CA, family C2, putative	0.0019	0.0309	0.3098
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0094	0.2665	0.4901
Echinococcus multilocularis	calpain 5	0.0019	0.0309	0.0309
Brugia malayi	Bromodomain containing protein	0.0037	0.0893	0.2358
Brugia malayi	Carboxylesterase family protein	0.0022	0.0412	0.1088
Echinococcus multilocularis	zinc finger protein	0.0021	0.0373	0.0373
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0059	0.1583	0.2911
Loa Loa (eye worm)	hypothetical protein	0.0086	0.2418	0.6382
Brugia malayi	calpain 7	0.0019	0.0309	0.0815
Trypanosoma brucei	antigen, putative	0.0019	0.0309	0.3098
Brugia malayi	Carboxylesterase family protein	0.013	0.3788	1
Schistosoma mansoni	hypothetical protein	0.0012	0.0104	0.019
Echinococcus multilocularis	para nitrobenzyl esterase	0.0022	0.0412	0.0412
Trypanosoma brucei	PAB1-binding protein , putative	0.0027	0.0568	1
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0412	0.1088
Trypanosoma cruzi	calpain cysteine peptidase, putative	0.0019	0.0309	0.3098
Echinococcus granulosus	para nitrobenzyl esterase	0.0022	0.0412	0.0412
Schistosoma mansoni	bromodomain containing protein	0.0063	0.1705	0.3135
Schistosoma mansoni	calpain C (C02 family)	0.0019	0.0309	0.0568
Trypanosoma brucei	calpain-like protein, putative	0.0019	0.0309	0.3098
Echinococcus multilocularis	calpain family protein 1, d	0.0044	0.1102	0.1102
Schistosoma mansoni	hypothetical protein	0.0183	0.5438	1
Brugia malayi	hypothetical protein	0.0086	0.2418	0.6382
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0094	0.2665	0.2665
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0035	0.0825	0.0825
Trypanosoma brucei	calpain-like protein, putative	0.0019	0.0309	0.3098
Echinococcus granulosus	calpain A	0.0066	0.1785	0.1785
Echinococcus multilocularis	geminin	0.0183	0.5438	0.5438
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0063	0.1685	0.3098
Loa Loa (eye worm)	hypothetical protein	0.013	0.3788	1
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0055	0.1457	1
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0019	0.0309	0.3098
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0412	0.1088
Loa Loa (eye worm)	bromodomain containing protein	0.0017	0.0264	0.0698
Schistosoma mansoni	calpain (C02 family)	0.0019	0.0309	0.0568
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0017	0.0265	0.0487
Brugia malayi	hypothetical protein	0.0017	0.027	0.0711
Echinococcus multilocularis	carboxylesterase 5A	0.013	0.3788	0.3788
Loa Loa (eye worm)	calpain family protein 1	0.0044	0.1102	0.2908
Loa Loa (eye worm)	carboxylesterase	0.0022	0.0412	0.1088
Loa Loa (eye worm)	hypothetical protein	0.013	0.3788	1
Brugia malayi	calpain 5	0.0019	0.0309	0.0815
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0028	0.0601	0.1587
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0412	0.1088
Trypanosoma brucei	kinesin, putative	0.0019	0.0309	0.3098
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0094	0.2665	0.2665
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0019	0.0309	0.3098
Echinococcus granulosus	BC026374 protein S09 family	0.0022	0.0412	0.0412
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0019	0.0309	0.3098
Loa Loa (eye worm)	PHD-finger family protein	0.002	0.0355	0.0937
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0024	0.0463	0.0851
Schistosoma mansoni	hypothetical protein	0.0035	0.0825	0.1517
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0896	0.2364
Onchocerca volvulus		0.0044	0.1102	0.8435
Loa Loa (eye worm)	calpain family protein 1	0.0063	0.1685	0.4447
Echinococcus multilocularis	methyl CpG binding domain protein 2	0.0017	0.0246	0.0246

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 661181