TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 410.413 | Formula: C18H17F3N4O2S
H donors: 2 H acceptors: 3 LogP: 3.42 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: CNc1ccc(cc1)n1nc(cc1c1ccc(cc1)NS(=O)(=O)C)C(F)(F)F
InChi: 1S/C18H17F3N4O2S/c1-22-13-7-9-15(10-8-13)25-16(11-17(23-25)18(19,20)21)12-3-5-14(6-4-12)24-28(2,26)27/h3-11,22,24H,1-2H3
InChiKey: HHZIDVRKOSETDY-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	GPCR, family 2	0.0047	0.0451	0.0451
Loa Loa (eye worm)	carboxylesterase	0.0017	0.0085	0.0091
Echinococcus multilocularis	carbonic anhydrase II	0.0268	0.313	0.313
Echinococcus multilocularis	Ankyrin	0.0113	0.1253	0.1253
Schistosoma mansoni	hypothetical protein	0.0112	0.1241	0.1231
Onchocerca volvulus	Neurogenic locus notch homolog	0.0011	0.0012	0.0083
Loa Loa (eye worm)	hypothetical protein	0.0121	0.1348	0.1444
Loa Loa (eye worm)	glutaminase	0.0273	0.3191	0.3417
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0015	0.0052	0.004
Brugia malayi	Carboxylesterase family protein	0.0017	0.0085	0.0266
Echinococcus granulosus	Ankyrin	0.0113	0.1253	0.1253
Echinococcus multilocularis	tar DNA binding protein	0.0061	0.0619	0.0619
Echinococcus multilocularis	dnaJ subfamily B	0.0833	1	1
Schistosoma mansoni	glutaminase	0.0273	0.3191	0.3183
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.015	0.1695	0.1815
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0047	0.0451	0.0451
Echinococcus multilocularis	nuclear factor of activated T cells 5	0.0576	0.6872	0.6872
Echinococcus multilocularis	neuroligin	0.0017	0.0085	0.0085
Mycobacterium leprae	CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE)	0.0234	0.272	1
Loa Loa (eye worm)	hypothetical protein	0.0121	0.1348	0.1444
Schistosoma mansoni	carbonic anhydrase-related	0.0171	0.1956	0.1947
Loa Loa (eye worm)	hypothetical protein	0.0778	0.9337	1
Echinococcus multilocularis	carbonic anhydrase	0.0171	0.1956	0.1956
Echinococcus granulosus	tar DNA binding protein	0.0061	0.0619	0.0619
Leishmania major	lanosterol 14-alpha-demethylase, putative	0.0152	0.1722	0.4974
Loa Loa (eye worm)	animal heme peroxidase	0.0121	0.1348	0.1444
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0171	0.1956	0.613
Brugia malayi	Latrophilin receptor protein 2	0.0047	0.0451	0.1414
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0037	0.0329	0.0927
Brugia malayi	Calcitonin receptor-like protein seb-1	0.015	0.1695	0.5312
Onchocerca volvulus		0.0121	0.1348	0.9601
Echinococcus multilocularis	acetylcholinesterase	0.0017	0.0085	0.0085
Echinococcus granulosus	nuclear factor of activated T cells 5	0.0576	0.6872	0.6872
Echinococcus granulosus	carbonic anhydrase	0.0171	0.1956	0.1956
Echinococcus multilocularis	carbonic anhydrase	0.0171	0.1956	0.1956
Loa Loa (eye worm)	animal heme peroxidase	0.0121	0.1348	0.1444
Schistosoma mansoni	carbonic anhydrase II (carbonate dehydratase II)	0.0268	0.313	0.3122
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0085	0.0091
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0047	0.0451	0.0451
Echinococcus granulosus	carboxylesterase 5A	0.0017	0.0085	0.0085
Loa Loa (eye worm)	hypothetical protein	0.0102	0.1119	0.1199
Schistosoma mansoni	carbonic anhydrase	0.0234	0.272	0.2712
Trichomonas vaginalis	glutaminase, putative	0.0273	0.3191	1
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0085	0.0091
Brugia malayi	Protein kinase domain containing protein	0.0112	0.1241	0.389
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0171	0.1956	0.613
Loa Loa (eye worm)	hypothetical protein	0.0121	0.1348	0.1444
Echinococcus granulosus	carbonic anhydrase II	0.0268	0.313	0.313
Loa Loa (eye worm)	TAR-binding protein	0.0061	0.0619	0.0663
Loa Loa (eye worm)	blistered cuticle protein 3	0.0121	0.1348	0.1444
Echinococcus granulosus	ankyrin repeat and death domain containing protein	0.0112	0.1241	0.1241
Schistosoma mansoni	retinoblastoma-binding protein 4 (rbbp4)	0.0113	0.1253	0.1243
Schistosoma mansoni	hypothetical protein	0.0047	0.0451	0.044
Loa Loa (eye worm)	acetylcholinesterase 1	0.0017	0.0085	0.0091
Brugia malayi	Inositol-1	0.0037	0.0329	0.103
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0085	0.0091
Echinococcus granulosus	BC026374 protein S09 family	0.0017	0.0085	0.0085
Loa Loa (eye worm)	animal heme peroxidase	0.0121	0.1348	0.1444
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0015	0.0052	0.0052
Echinococcus granulosus	acetylcholinesterase	0.0017	0.0085	0.0085
Onchocerca volvulus		0.0017	0.0085	0.0604
Echinococcus multilocularis	family S9 non peptidase ue (S09 family)	0.0017	0.0085	0.0085
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0058	0.0586	0.0628
Onchocerca volvulus		0.0058	0.0586	0.4175
Schistosoma mansoni	hypothetical protein	0.0164	0.1865	0.1856
Trichomonas vaginalis	spcc417.12 protein, putative	0.0017	0.0085	0.0154
Leishmania major	carbonic anhydrase family protein, putative	0.0234	0.272	0.8536
Brugia malayi	F/Y-rich N-terminus family protein	0.0018	0.0092	0.029
Echinococcus multilocularis	acetylcholinesterase	0.0017	0.0085	0.0085
Mycobacterium ulcerans	carboxylesterase, LipT	0.0151	0.1714	0.484
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.015	0.1695	0.5312
Mycobacterium tuberculosis	Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM)	0.0152	0.1722	1
Schistosoma mansoni	netrin receptor unc5	0.0112	0.1241	0.1231
Mycobacterium tuberculosis	Beta-carbonic anhydrase CanB	0.0133	0.149	0.8582
Echinococcus multilocularis	mixed lineage leukemia protein mll	0.0015	0.0052	0.0052
Schistosoma mansoni	tar DNA-binding protein	0.0061	0.0619	0.0608
Schistosoma mansoni	inositol monophosphatase	0.0037	0.0329	0.0317
Mycobacterium tuberculosis	Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase)	0.0101	0.1106	0.6234
Onchocerca volvulus	Netrin receptor homolog	0.0112	0.1241	0.884
Echinococcus granulosus	netrin receptor unc 5	0.0112	0.1241	0.1241
Brugia malayi	glutaminase DH11.1	0.0273	0.3191	1
Brugia malayi	Carboxylesterase family protein	0.0017	0.0085	0.0266
Onchocerca volvulus	Huntingtin homolog	0.0126	0.1404	1
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0017	0.0085	0.0073
Loa Loa (eye worm)	eukaryotic-type carbonic anhydrase	0.0171	0.1956	0.2095
Brugia malayi	Putative carbonic anhydrase 5 precursor	0.0268	0.313	0.9811
Trichomonas vaginalis	conserved hypothetical protein	0.0101	0.1106	0.339
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0085	0.0091
Plasmodium falciparum	carbonic anhydrase	0.0171	0.1956	0.5
Leishmania major	carbonic anhydrase-like protein	0.0268	0.313	1
Mycobacterium ulcerans	cytochrome P450 51B1 Cyp51B1	0.0152	0.1722	0.4869
Schistosoma mansoni	hypothetical protein	0.0833	1	1
Brugia malayi	RNA recognition motif domain containing protein	0.0061	0.0619	0.1941
Brugia malayi	hypothetical protein	0.0126	0.1404	0.4401
Trypanosoma cruzi	carbonic anhydrase-like protein, putative	0.0268	0.313	1
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0171	0.1956	0.613
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0085	0.0091
Trypanosoma brucei	carbonic anhydrase-like protein	0.0268	0.313	1
Schistosoma mansoni	tar DNA-binding protein	0.0061	0.0619	0.0608
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0451	0.0483
Brugia malayi	Carbonic anhydrase like protein 2 precursor	0.0171	0.1956	0.613
Trichomonas vaginalis	carboxylesterase domain containing protein, putative	0.0017	0.0085	0.0154
Loa Loa (eye worm)	hypothetical protein	0.015	0.1695	0.1815
Loa Loa (eye worm)	animal heme peroxidase	0.0121	0.1348	0.1444
Loa Loa (eye worm)	inositol-1	0.0037	0.0329	0.0352
Echinococcus granulosus	neuroligin	0.0017	0.0085	0.0085
Loa Loa (eye worm)	hypothetical protein	0.0121	0.1348	0.1444
Brugia malayi	Carbonic anhydrase like protein 2 precursor	0.0171	0.1956	0.613
Schistosoma mansoni	hypothetical protein	0.0047	0.0451	0.044
Loa Loa (eye worm)	MH2 domain-containing protein	0.0115	0.1277	0.1368
Echinococcus granulosus	carbonic anhydrase	0.0171	0.1956	0.1956
Brugia malayi	Animal haem peroxidase family protein	0.0121	0.1348	0.4225
Loa Loa (eye worm)	hypothetical protein	0.0113	0.1253	0.1342
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0017	0.0085	0.0073
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0017	0.0085	0.0073
Schistosoma mansoni	carbonic anhydrase	0.0171	0.1956	0.1947
Onchocerca volvulus		0.0121	0.1348	0.9601
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0112	0.1241	0.1329
Echinococcus multilocularis	netrin receptor unc 5	0.0112	0.1241	0.1241
Onchocerca volvulus		0.0017	0.0085	0.0604
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0085	0.0091
Brugia malayi	Carboxylesterase family protein	0.0017	0.0085	0.0266
Echinococcus granulosus	para nitrobenzyl esterase	0.0017	0.0085	0.0085
Schistosoma mansoni	acetylcholinesterase	0.0017	0.0085	0.0073
Loa Loa (eye worm)	hypothetical protein	0.0126	0.1404	0.1504
Onchocerca volvulus	Peroxidasin homolog	0.0121	0.1348	0.9601
Loa Loa (eye worm)	RNA binding protein	0.0061	0.0619	0.0663
Loa Loa (eye worm)	hypothetical protein	0.0112	0.1241	0.1329
Brugia malayi	Animal haem peroxidase family protein	0.0121	0.1348	0.4225
Loa Loa (eye worm)	histone methyltransferase	0.0018	0.0095	0.0102
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0047	0.0451	0.0483
Loa Loa (eye worm)	hypothetical protein	0.0171	0.1956	0.2095
Onchocerca volvulus		0.0017	0.0085	0.0604
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0111	0.1222	0.5491
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0268	0.313	0.9811
Echinococcus granulosus	geminin	0.0164	0.1865	0.1865
Loa Loa (eye worm)	transcription factor SMAD2	0.0115	0.1277	0.1368
Schistosoma mansoni	hypothetical protein	0.0047	0.0451	0.044
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0124	0.1383	0.1373
Echinococcus granulosus	cpg binding protein	0.0062	0.0627	0.0627
Trypanosoma cruzi	Lanosterol 14-alpha demethylase	0.0152	0.1722	0.4974
Loa Loa (eye worm)	carboxylesterase	0.0017	0.0085	0.0091
Trichomonas vaginalis	conserved hypothetical protein	0.0101	0.1106	0.339
Trichomonas vaginalis	inositol monophosphatase, putative	0.0037	0.0329	0.0927
Brugia malayi	Peroxidasin	0.0121	0.1348	0.4225
Onchocerca volvulus	Peroxidase homolog	0.0121	0.1348	0.9601
Onchocerca volvulus	Huntingtin homolog	0.0126	0.1404	1
Echinococcus granulosus	death domain containing protein	0.0112	0.1241	0.1241
Brugia malayi	latrophilin 2 splice variant baaae	0.0102	0.1119	0.3507
Schistosoma mansoni	hypothetical protein	0.0047	0.0451	0.044
Schistosoma mansoni	cpg binding protein	0.0058	0.0586	0.0575
Loa Loa (eye worm)	hypothetical protein	0.0171	0.1956	0.2095
Loa Loa (eye worm)	hypothetical protein	0.0121	0.1348	0.1444
Schistosoma mansoni	peroxidasin	0.0121	0.1348	0.1338
Loa Loa (eye worm)	hypothetical protein	0.0121	0.1348	0.1444
Schistosoma mansoni	tar DNA-binding protein	0.0061	0.0619	0.0608
Brugia malayi	CXXC zinc finger family protein	0.0058	0.0586	0.1837
Onchocerca volvulus	Peroxidase homolog	0.0121	0.1348	0.9601
Mycobacterium ulcerans	carbonic anhydrase	0.0101	0.1106	0.2714
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0018	0.0095	0.0095
Echinococcus multilocularis	peroxidasin	0.0121	0.1348	0.1348
Schistosoma mansoni	hypothetical protein	0.0171	0.1956	0.1947
Echinococcus multilocularis	carbonic anhydrase	0.0171	0.1956	0.1956
Brugia malayi	hypothetical protein	0.0017	0.0085	0.0266
Trypanosoma cruzi	Lanosterol 14-alpha demethylase	0.0152	0.1722	0.4974
Loa Loa (eye worm)	hypothetical protein	0.0126	0.1404	0.1504
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0017	0.0085	0.0073
Brugia malayi	Carboxylesterase family protein	0.0017	0.0085	0.0266
Echinococcus granulosus	peroxidasin	0.0121	0.1348	0.1348
Schistosoma mansoni	gliotactin	0.0017	0.0085	0.0073
Loa Loa (eye worm)	carboxylesterase	0.0017	0.0085	0.0091
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0085	0.0091
Echinococcus granulosus	carbonic anhydrase	0.0171	0.1956	0.1956
Schistosoma mansoni	tar DNA-binding protein	0.0061	0.0619	0.0608
Brugia malayi	Animal haem peroxidase family protein	0.0121	0.1348	0.4225
Schistosoma mansoni	hypothetical protein	0.0102	0.1119	0.1109
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0085	0.0091
Schistosoma mansoni	BC026374 protein (S09 family)	0.0017	0.0085	0.0073
Echinococcus multilocularis	cpg binding protein	0.0062	0.0627	0.0627
Schistosoma mansoni	hypothetical protein	0.0164	0.1865	0.1856
Wolbachia endosymbiont of Brugia malayi	fructose-1,6-bisphosphatase	0.0037	0.0329	0.5
Echinococcus multilocularis	carboxylesterase 5A	0.0017	0.0085	0.0085
Onchocerca volvulus		0.0017	0.0085	0.0604
Loa Loa (eye worm)	hypothetical protein	0.0121	0.1348	0.1444
Loa Loa (eye worm)	eukaryotic-type carbonic anhydrase	0.0268	0.313	0.3352
Loa Loa (eye worm)	glutaminase 2	0.0273	0.3191	0.3417
Onchocerca volvulus	Dual oxidase homolog	0.0121	0.1348	0.9601
Onchocerca volvulus		0.0017	0.0085	0.0604
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0047	0.0451	0.1414
Schistosoma mansoni	carbonic anhydrase-related	0.0171	0.1956	0.1947
Loa Loa (eye worm)	hypothetical protein	0.0121	0.1348	0.1444
Mycobacterium tuberculosis	Inositol-1-monophosphatase SuhB	0.0033	0.0281	0.1199
Echinococcus multilocularis	para nitrobenzyl esterase	0.0017	0.0085	0.0085
Echinococcus granulosus	GPCR family 2	0.0047	0.0451	0.0451
Echinococcus multilocularis	ankyrin repeat and death domain containing protein	0.0112	0.1241	0.1241
Schistosoma mansoni	carbonic anhydrase II (carbonate dehydratase II)	0.0268	0.313	0.3122
Brugia malayi	hypothetical protein	0.0121	0.1348	0.4225
Loa Loa (eye worm)	hypothetical protein	0.0121	0.1348	0.1444
Schistosoma mansoni	neuroligin 3 (S09 family)	0.0017	0.0085	0.0073
Loa Loa (eye worm)	hypothetical protein	0.0121	0.1348	0.1444
Echinococcus multilocularis	geminin	0.0164	0.1865	0.1865
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0047	0.0451	0.0451
Mycobacterium ulcerans	carbonic anhydrase	0.0234	0.272	0.8356
Brugia malayi	TAR-binding protein	0.0061	0.0619	0.1941
Loa Loa (eye worm)	hypothetical protein	0.0121	0.1348	0.1444
Brugia malayi	RNA binding protein	0.0061	0.0619	0.1941
Schistosoma mansoni	peroxidasin	0.0121	0.1348	0.1338
Toxoplasma gondii	hypothetical protein	0.0171	0.1956	1
Schistosoma mansoni	cpg binding protein	0.0062	0.0627	0.0616
Schistosoma mansoni	ankyrin 23/unc44	0.0112	0.1241	0.1231
Brugia malayi	Blistered cuticle protein 3	0.0121	0.1348	0.4225
Brugia malayi	Uncoordinated protein 44	0.0112	0.1241	0.389
Mycobacterium ulcerans	glutaminase	0.0273	0.3191	1
Brugia malayi	Death domain containing protein	0.0112	0.1241	0.389
Schistosoma mansoni	tar DNA-binding protein	0.0061	0.0619	0.0608
Echinococcus granulosus	mixed lineage leukemia protein mll	0.0015	0.0052	0.0052
Brugia malayi	MH2 domain containing protein	0.0115	0.1277	0.4004
Echinococcus multilocularis	BC026374 protein (S09 family)	0.0017	0.0085	0.0085
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0037	0.0329	0.0927
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0061	0.0619	0.0663
Brugia malayi	Carboxylesterase family protein	0.0017	0.0085	0.0266
Schistosoma mansoni	inositol monophosphatase	0.0037	0.0329	0.0317
Echinococcus multilocularis	inositol monophosphatase 1	0.0037	0.0329	0.0329
Trypanosoma brucei	Lanosterol 14-alpha demethylase	0.0152	0.1722	0.4974
Loa Loa (eye worm)	hypothetical protein	0.0121	0.1348	0.1444
Echinococcus granulosus	inositol monophosphatase 1	0.0037	0.0329	0.0329
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0085	0.0091
Schistosoma mansoni	cpg binding protein	0.0062	0.0627	0.0616
Brugia malayi	Animal haem peroxidase family protein	0.0121	0.1348	0.4225
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0018	0.0095	0.0095
Brugia malayi	Carboxylesterase family protein	0.0017	0.0085	0.0266
Mycobacterium tuberculosis	Carboxylesterase LipT	0.0151	0.1714	0.995
Echinococcus granulosus	acetylcholinesterase	0.0017	0.0085	0.0085
Loa Loa (eye worm)	hypothetical protein	0.0121	0.1348	0.1444
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0047	0.0451	0.0451
Onchocerca volvulus	Peroxidasin homolog	0.0121	0.1348	0.9601
Trypanosoma cruzi	carbonic anhydrase-like protein, putative	0.0268	0.313	1
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0015	0.0052	0.0052
Onchocerca volvulus	Chorion peroxidase homolog	0.0121	0.1348	0.9601
Entamoeba histolytica	carbonic anhydrase, putative	0.0234	0.272	1
Loa Loa (eye worm)	carbonic anhydrase 3	0.0268	0.313	0.3352
Loa Loa (eye worm)	hypothetical protein	0.0121	0.1348	0.1444
Onchocerca volvulus		0.0121	0.1348	0.9601
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0112	0.1241	0.389
Schistosoma mansoni	carbonic anhydrase-related	0.0171	0.1956	0.1947
Brugia malayi	Animal haem peroxidase family protein	0.0121	0.1348	0.4225
Echinococcus granulosus	family S9 non peptidase ue S09 family	0.0017	0.0085	0.0085

Activities

Activity type	Activity value	Assay description	Source	Reference
Inhibition (binding)	= 14 %	In vitro inhibitory activity against prostaglandin G/H synthase 1 (COX-1) from the microsomal fraction of ram seminal vesicles at 10 microM concentration	ChEMBL.	15026050
Inhibition (binding)	= 14 %	In vitro inhibitory activity against prostaglandin G/H synthase 1 (COX-1) from the microsomal fraction of ram seminal vesicles at 10 microM concentration	ChEMBL.	15026050
Inhibition (binding)	= 42 %	In vitro inhibitory activity against human recombinant prostaglandin G/H synthase 2 (COX-2) at 10 uM expressed in sf-9 cells infected with baculovirus	ChEMBL.	15026050
Inhibition (binding)	= 42 %	In vitro inhibitory activity against human recombinant prostaglandin G/H synthase 2 (COX-2) at 10 uM expressed in sf-9 cells infected with baculovirus	ChEMBL.	15026050

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL297449

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 66247