Detailed information for compound 672554

Basic information

Technical information
  • TDR Targets ID: 672554
  • Name: N-(2,6-diethylphenyl)-2-oxochromene-3-carboxa mide
  • MW: 321.37 | Formula: C20H19NO3
  • H donors: 1 H acceptors: 2 LogP: 4.55 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCc1cccc(c1NC(=O)c1cc2ccccc2oc1=O)CC
  • InChi: 1S/C20H19NO3/c1-3-13-9-7-10-14(4-2)18(13)21-19(22)16-12-15-8-5-6-11-17(15)24-20(16)23/h5-12H,3-4H2,1-2H3,(H,21,22)
  • InChiKey: XQEBHACDPMFKSR-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(2,6-diethylphenyl)-2-oxo-chromene-3-carboxamide
  • N-(2,6-diethylphenyl)-2-oxo-3-chromenecarboxamide
  • N-(2,6-diethylphenyl)-2-keto-chromene-3-carboxamide
  • Oprea1_622814
  • Oprea1_373558
  • 2-Oxo-2H-chromene-3-carboxylic acid (2,6-diethyl-phenyl)-amide
  • BAS 04805332
  • ST5020108
  • ZINC00145169

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) CYL-1 protein 0.0062 0.0204 0.0536
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0124 0.0124
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0064 0.0212 0.0874
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0059 0.0275
Echinococcus multilocularis peptidase Clp (S14 family) 0.005 0.0146 0.0146
Brugia malayi beta-NAC-like protein 0.0034 0.0075 0.0184
Trichomonas vaginalis cyclin A, putative 0.0062 0.0204 0.0949
Brugia malayi Niemann-Pick C1 protein precursor 0.0192 0.0793 0.2119
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0019 0.0019
Schistosoma mansoni smad1 5 8 and 0.0042 0.0113 0.0113
Loa Loa (eye worm) hypothetical protein 0.0019 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0022 0.0019 0.0038
Echinococcus granulosus cdk5 and abl1 enzyme substrate 1 0.0062 0.0204 0.0204
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0022 0.0019 0.0033
Loa Loa (eye worm) cyclin domain-containing protein 0.0062 0.0204 0.0536
Mycobacterium tuberculosis Conserved protein 0.007 0.0241 0.1226
Onchocerca volvulus 0.007 0.0241 0.1095
Plasmodium vivax hypothetical protein, conserved 0.0062 0.0204 0.236
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0022 0.0019 0.0033
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.003 0.0059 0.0059
Plasmodium falciparum basic transcription factor 3b, putative 0.0034 0.0075 0.0338
Brugia malayi hypothetical protein 0.0062 0.0204 0.0531
Brugia malayi photoreceptor-specific nuclear receptor 0.0022 0.0019 0.0033
Loa Loa (eye worm) hypothetical protein 0.0022 0.0019 0.0038
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0064 0.0212 0.0212
Loa Loa (eye worm) cyclin domain-containing protein 0.0062 0.0204 0.0536
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0022 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0097 0.0362 0.0962
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0072 0.0249 0.091
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0019 0.0019
Leishmania major basic transcription factor 3a, putative 0.0034 0.0075 0.0229
Brugia malayi nuclear hormone receptor 0.0022 0.0019 0.0033
Brugia malayi beta-lactamase 0.007 0.0241 0.0632
Schistosoma mansoni hypothetical protein 0.0062 0.0204 0.0204
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0091 0.0333 0.1312
Loa Loa (eye worm) hypothetical protein 0.0019 0.0007 0.0005
Trichomonas vaginalis PIKK family atypical protein kinase 0.0091 0.0333 0.1551
Loa Loa (eye worm) hypothetical protein 0.0022 0.0019 0.0038
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0019 0.0033
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0128 0.0502 0.0502
Echinococcus multilocularis FTZ F1 alpha 0.0022 0.0019 0.0019
Schistosoma mansoni hypothetical protein 0.0493 0.2167 0.2167
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0022 0.0021 0.0021
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.0212 0.0731
Loa Loa (eye worm) steroid hormone receptor 0.0022 0.0019 0.0038
Schistosoma mansoni cyclin k 0.0062 0.0204 0.0204
Plasmodium vivax protein kinase Crk2 0.0179 0.0736 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0067 0.0227 0.1059
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0022 0.0019 0.0019
Trichomonas vaginalis cyclins, putative 0.0489 0.2148 1
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0192 0.0793 0.3613
Brugia malayi Cyclin, N-terminal domain containing protein 0.0489 0.2148 0.5771
Trichomonas vaginalis PIKK family atypical protein kinase 0.0054 0.0165 0.0767
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1668 0.7515 0.7515
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0124 0.0124
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0013 0.0059
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0022 0.0019 0.0019
Brugia malayi beta-lactamase family protein 0.007 0.0241 0.0632
Loa Loa (eye worm) phosphatidylinositol 3 0.0091 0.0333 0.0885
Schistosoma mansoni tar DNA-binding protein 0.0132 0.0523 0.0523
Schistosoma mansoni peptidase Clp (S14 family) 0.0076 0.0265 0.0265
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0013 0.0059
Brugia malayi Cyclin, N-terminal domain containing protein 0.0062 0.0204 0.0531
Loa Loa (eye worm) MH1 domain-containing protein 0.0042 0.0113 0.0291
Schistosoma mansoni smad 0.0019 0.0007 0.0007
Loa Loa (eye worm) latrophilin receptor protein 2 0.0128 0.0502 0.134
Toxoplasma gondii cyclin domain protein, cyclin H family protein 0.0062 0.0204 0.2442
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0022 0.0019 0.0038
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0022 0.0019 0.0033
Echinococcus granulosus Smad4 0.0042 0.0113 0.0113
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.003 0.0059 0.0141
Schistosoma mansoni hypothetical protein 0.007 0.0239 0.0239
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0179 0.0736 0.0736
Toxoplasma gondii NAC domain-containing protein 0.0034 0.0075 0.0837
Brugia malayi cell division control protein 2 homolog 0.0179 0.0736 0.1966
Loa Loa (eye worm) RNA binding protein 0.0132 0.0523 0.1396
Echinococcus multilocularis transcription factor btf3 0.0034 0.0075 0.0075
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0091 0.0333 0.1446
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0022 0.0019 0.0019
Leishmania major phosphatidylinositol 3-related kinase, putative 0.003 0.0059 0.0155
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0028 0.0046 0.0046
Trichomonas vaginalis cyclin B, putative 0.0489 0.2148 1
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.007 0.0241 0.1226
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0195 0.0806 0.0806
Schistosoma mansoni cyclin G2 0.0062 0.0204 0.0204
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0076 0.0265 0.5
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0179 0.0736 0.3345
Schistosoma mansoni smad1 5 8 and 0.0042 0.0113 0.0113
Schistosoma mansoni thyroid hormone receptor 0.0168 0.0686 0.0686
Schistosoma mansoni g1/s-specific cyclin C 0.0062 0.0204 0.0204
Echinococcus granulosus mothers against decapentaplegic 5 0.0042 0.0113 0.0113
Echinococcus multilocularis Smad4 0.0042 0.0113 0.0113
Schistosoma mansoni cpg binding protein 0.0089 0.0326 0.0326
Trichomonas vaginalis penicillin-binding protein, putative 0.007 0.0241 0.1122
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0143 0.0666
Loa Loa (eye worm) nuclear factor I 0.0023 0.0027 0.006
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0091 0.0333 0.0333
Entamoeba histolytica transcription factor BTF3, putative 0.0034 0.0075 0.0229
Onchocerca volvulus Protein CNPPD1 homolog 0.0062 0.0204 0.0921
Schistosoma mansoni proteasome subunit alpha 1 (T01 family) 0.0062 0.0204 0.0204
Schistosoma mansoni steroid hormone receptor ad4bp 0.0022 0.0019 0.0019
Schistosoma mansoni hypothetical protein 0.0128 0.0502 0.0502
Trichomonas vaginalis cyclin B3, putative 0.0062 0.0204 0.0949
Loa Loa (eye worm) TAR-binding protein 0.0132 0.0523 0.1396
Onchocerca volvulus 0.0097 0.0362 0.166
Trichomonas vaginalis cyclin B3, putative 0.0258 0.1093 0.509
Loa Loa (eye worm) hypothetical protein 0.0022 0.0019 0.0038
Echinococcus multilocularis cyclin t1 0.0062 0.0204 0.0204
Loa Loa (eye worm) hypothetical protein 0.0062 0.0204 0.0536
Trichomonas vaginalis conserved hypothetical protein 0.0062 0.0204 0.0949
Echinococcus multilocularis cyclin G2 0.0062 0.0204 0.0204
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0019 0.0033
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0022 0.0021 0.0021
Echinococcus granulosus FTZ F1 alpha 0.0022 0.0019 0.0019
Echinococcus multilocularis cyclin y 0.0062 0.0204 0.0204
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0146 0.0588 0.0588
Trypanosoma brucei cyclin dependent kinase-binding protein, putative 0.0062 0.0204 0.0692
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0076 0.0265 0.0265
Brugia malayi Cyclin, N-terminal domain containing protein 0.0062 0.0204 0.0531
Leishmania major cyclin 0.0489 0.2148 1
Trichomonas vaginalis cyclins, putative 0.0062 0.0204 0.0949
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0179 0.0736 0.9074
Trichomonas vaginalis cyclin B, putative 0.0489 0.2148 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0013 0.0059
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0019 0.0033
Onchocerca volvulus 0.007 0.0241 0.1095
Entamoeba histolytica hypothetical protein 0.007 0.0239 0.1003
Entamoeba histolytica cell division protein kinase 2, putative 0.0179 0.0736 0.3345
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0124 0.0124
Echinococcus granulosus cyclin b3 0.0258 0.1093 0.1093
Echinococcus multilocularis G2:mitotic specific cyclin B3 0.0834 0.3717 0.3717
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0022 0.0019 0.0019
Brugia malayi Cyclin, N-terminal domain containing protein 0.0062 0.0204 0.0531
Brugia malayi cyclin fold protein 1 variant b 0.0062 0.0204 0.0531
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.005 0.0146 0.0744
Brugia malayi RNA binding protein 0.0132 0.0523 0.1392
Echinococcus granulosus mothers against decapentaplegic 6 0.0019 0.0007 0.0007
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0019 0.0033
Trichomonas vaginalis PIKK family atypical protein kinase 0.0054 0.0167 0.0779
Loa Loa (eye worm) cyclin domain-containing protein 0.0062 0.0204 0.0536
Mycobacterium ulcerans hypothetical protein 0.0023 0.0026 0.0994
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0124 0.0124
Echinococcus granulosus cyclin B 0.0489 0.2148 0.2148
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0013 0.0059
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0026 0.0994
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0026 0.0039 0.1484
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0022 0.0019 0.0038
Echinococcus multilocularis Cyclin L1 0.0062 0.0204 0.0204
Loa Loa (eye worm) Smad1 0.0042 0.0113 0.0291
Loa Loa (eye worm) beta-lactamase 0.007 0.0241 0.0636
Loa Loa (eye worm) hypothetical protein 0.0082 0.0295 0.0782
Trichomonas vaginalis cyclin D, putative 0.0062 0.0204 0.0949
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0064 0.0212 0.0553
Loa Loa (eye worm) hypothetical protein 0.007 0.0241 0.0636
Mycobacterium ulcerans hypothetical protein 0.007 0.0241 0.9104
Loa Loa (eye worm) ICD-1 protein 0.0034 0.0075 0.0189
Trypanosoma brucei mitotic cyclin 6 0.0489 0.2148 1
Mycobacterium leprae conserved hypothetical protein 0.007 0.0241 0.9104
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0062 0.0204 0.156
Mycobacterium leprae Probable lipase LipE 0.007 0.0241 0.9104
Loa Loa (eye worm) hypothetical protein 0.007 0.0241 0.0636
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0022 0.0019 0.0019
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0179 0.0736 0.3345
Trichomonas vaginalis cyclins, putative 0.0489 0.2148 1
Entamoeba histolytica hypothetical protein 0.007 0.0239 0.1003
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0091 0.0333 0.1446
Trichomonas vaginalis cyclins, putative 0.0489 0.2148 1
Echinococcus granulosus Niemann Pick C1 protein 0.0192 0.0793 0.0793
Giardia lamblia Cyclin A 0.0258 0.1093 0.4575
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0013 0.0059
Trichomonas vaginalis CMGC family protein kinase 0.0179 0.0736 0.3427
Echinococcus multilocularis cyclins 0.0258 0.1093 0.1093
Onchocerca volvulus 0.0022 0.0019 0.0057
Echinococcus granulosus cyclin A3 4 0.0062 0.0204 0.0204
Schistosoma mansoni serine/threonine protein kinase 0.0179 0.0736 0.0736
Trypanosoma cruzi transcription factor btf3, putative 0.0034 0.0075 0.0076
Trichomonas vaginalis PIKK family atypical protein kinase 0.0067 0.0227 0.1059
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0031 0.0146
Entamoeba histolytica cyclin family protein 0.0258 0.1093 0.5029
Loa Loa (eye worm) cyclin domain-containing protein 0.0062 0.0204 0.0536
Mycobacterium tuberculosis Probable lipase LipE 0.007 0.0241 0.1226
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0022 0.0019 0.0019
Plasmodium vivax cyclin 4, putative 0.0062 0.0204 0.236
Trichomonas vaginalis esterase, putative 0.007 0.0241 0.1122
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0076 0.0265 0.0265
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0022 0.0019 0.0019
Entamoeba histolytica cell division protein kinase 2, putative 0.0179 0.0736 0.3345
Trichomonas vaginalis CMGC family protein kinase 0.0179 0.0736 0.3427
Onchocerca volvulus Cyclin L homolog 0.0062 0.0204 0.0921
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0076 0.0265 1
Toxoplasma gondii hypothetical protein 0.0062 0.0204 0.2442
Trichomonas vaginalis D-aminoacylase, putative 0.007 0.0241 0.1122
Loa Loa (eye worm) hypothetical protein 0.0022 0.0019 0.0038
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0124 0.0124
Echinococcus granulosus cyclin dependent kinase 5 0.0179 0.0736 0.0736
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0026 0.0994
Echinococcus granulosus tumor protein p63 0.0662 0.2935 0.2935
Schistosoma mansoni cyclin B 0.0489 0.2148 0.2148
Trypanosoma brucei transcription factor BTF3, putative 0.0034 0.0075 0.0076
Echinococcus granulosus GPCR family 2 0.0128 0.0502 0.0502
Toxoplasma gondii hypothetical protein 0.0195 0.081 1
Trichomonas vaginalis D-aminoacylase, putative 0.007 0.0241 0.1122
Loa Loa (eye worm) hypothetical protein 0.0022 0.0019 0.0038
Loa Loa (eye worm) hypothetical protein 0.0076 0.0265 0.07
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0076 0.0265 0.3236
Schistosoma mansoni tar DNA-binding protein 0.0132 0.0523 0.0523
Mycobacterium ulcerans beta-lactamase 0.007 0.0241 0.9104
Plasmodium falciparum cyclin dependent kinase binding protein, putative 0.0062 0.0204 0.156
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0075 0.0349
Mycobacterium ulcerans lipase LipD 0.007 0.0241 0.9104
Echinococcus multilocularis thyroid hormone receptor alpha 0.0168 0.0686 0.0686
Loa Loa (eye worm) cyclin domain-containing protein 0.0062 0.0204 0.0536
Schistosoma mansoni microtubule-associated protein tau 0.2214 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0062 0.0204 0.0949
Brugia malayi ecdysteroid receptor 0.0022 0.0019 0.0033
Leishmania major hypothetical protein, conserved 0.007 0.0241 0.1012
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0026 0.0134
Echinococcus multilocularis microtubule associated protein 2 0.2214 1 1
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0076 0.0265 0.5
Brugia malayi Steroid receptor seven-up type 2 0.0022 0.0019 0.0033
Schistosoma mansoni cellular tumor antigen P53 0.0097 0.0362 0.0362
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.005 0.0146 0.0744
Echinococcus multilocularis beta LACTamase domain containing family member 0.007 0.0241 0.0241
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0022 0.0019 0.0019
Brugia malayi Cyclin C 0.0062 0.0204 0.0531
Schistosoma mansoni transcription factor btf3 0.0034 0.0075 0.0075
Trypanosoma cruzi cyclin 6, putative 0.0489 0.2148 1
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0076 0.0265 1
Echinococcus granulosus geminin 0.0493 0.2167 0.2167
Loa Loa (eye worm) hypothetical protein 0.0022 0.0019 0.0038
Schistosoma mansoni tar DNA-binding protein 0.0132 0.0523 0.0523
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0179 0.0736 0.197
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0026 0.0039 0.1484
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0022 0.0019 0.0033
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0143 0.0666
Schistosoma mansoni hypothetical protein 0.0079 0.0282 0.0282
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0026 0.0994
Echinococcus granulosus beta LACTamase domain containing family member 0.007 0.0241 0.0241
Loa Loa (eye worm) cyclin C 0.0062 0.0204 0.0536
Mycobacterium tuberculosis Conserved protein 0.007 0.0241 0.1226
Trichomonas vaginalis CMGC family protein kinase 0.0179 0.0736 0.3427
Echinococcus multilocularis protein dispatched 1 0.0094 0.0348 0.0348
Leishmania major mitotic cyclin, putative 0.0062 0.0204 0.0836
Trypanosoma brucei cdc2-related kinase 1 0.0179 0.0736 0.3241
Trichomonas vaginalis PIKK family atypical protein kinase 0.0072 0.0249 0.1158
Brugia malayi MH2 domain containing protein 0.0042 0.0113 0.0286
Brugia malayi beta-lactamase family protein 0.007 0.0241 0.0632
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0019 0.0019
Schistosoma mansoni hypothetical protein 0.0493 0.2167 0.2167
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0128 0.0502 0.0502
Mycobacterium ulcerans esterase/lipase LipP 0.007 0.0241 0.9104
Echinococcus multilocularis cpg binding protein 0.0094 0.0349 0.0349
Trypanosoma cruzi transcription factor btf3, putative 0.0034 0.0075 0.0076
Brugia malayi Cyclin, N-terminal domain containing protein 0.0062 0.0204 0.0531
Trichomonas vaginalis PIKK family atypical protein kinase 0.0072 0.0249 0.1158
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0022 0.0019 0.0019
Entamoeba histolytica hypothetical protein 0.007 0.0239 0.1003
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0026 0.0053
Trichomonas vaginalis cyclins, putative 0.0489 0.2148 1
Loa Loa (eye worm) phosphatidylinositol 3 0.003 0.0059 0.0146
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0022 0.0019 0.0057
Brugia malayi RNA recognition motif domain containing protein 0.0132 0.0523 0.1392
Loa Loa (eye worm) hypothetical protein 0.007 0.0241 0.0636
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.007 0.0241 0.0241
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0179 0.0736 0.197
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0075 0.0349
Brugia malayi Cyclin, N-terminal domain containing protein 0.0062 0.0204 0.0531
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0128 0.0502 0.0502
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0091 0.0333 0.0333
Schistosoma mansoni cpg binding protein 0.0094 0.0349 0.0349
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0076 0.0265 1
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0072 0.0249 0.105
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0013 0.0059
Loa Loa (eye worm) cyclin domain-containing protein 0.0062 0.0204 0.0536
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.0212 0.0731
Schistosoma mansoni Cyclin fold protein 0.0062 0.0204 0.0204
Brugia malayi steroid hormone receptor 0.0022 0.0019 0.0033
Brugia malayi Latrophilin receptor protein 2 0.0128 0.0502 0.1336
Schistosoma mansoni cyclin B3 0.0834 0.3717 0.3717
Echinococcus granulosus cyclin y 0.0062 0.0204 0.0204
Onchocerca volvulus Protein ultraspiracle homolog 0.0022 0.0019 0.0057
Loa Loa (eye worm) hypothetical protein 0.0022 0.0019 0.0038
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0076 0.0265 1
Echinococcus granulosus neuropeptide receptor A26 0.0908 0.4055 0.4055
Trypanosoma cruzi cdc2-related kinase 1 0.0179 0.0736 0.3241
Schistosoma mansoni hypothetical protein 0.0146 0.0588 0.0588
Echinococcus granulosus cyclin y 0.0062 0.0204 0.0204
Giardia lamblia Hypothetical protein 0.0258 0.1093 0.4575
Toxoplasma gondii ABC1 family protein 0.007 0.0241 0.2907
Giardia lamblia Kinase, CMGC CDK 0.0179 0.0736 0.2738
Echinococcus multilocularis mothers against decapentaplegic 6 0.0019 0.0007 0.0007
Schistosoma mansoni hypothetical protein 0.0062 0.0204 0.0204
Trichomonas vaginalis helicase, putative 0.002 0.0013 0.0059
Entamoeba histolytica cyclin family protein 0.0258 0.1093 0.5029
Entamoeba histolytica hypothetical protein 0.0062 0.0204 0.0836
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0013 0.0059
Trichomonas vaginalis cyclin B3, putative 0.0062 0.0204 0.0949
Echinococcus multilocularis neuropeptide receptor A26 0.0908 0.4055 0.4055
Schistosoma mansoni transcription factor LCR-F1 0.007 0.0239 0.0239
Toxoplasma gondii cyclin, N-terminal domain-containing protein 0.0062 0.0204 0.2442
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0022 0.0019 0.0033
Trichomonas vaginalis conserved hypothetical protein 0.0062 0.0204 0.0949
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0022 0.0021 0.0021
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0124 0.0124
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0013 0.0059
Schistosoma mansoni coup transcription factor 0.0022 0.0019 0.0019
Trypanosoma cruzi mitotic cyclin, putative 0.0062 0.0204 0.0692
Schistosoma mansoni Smad4 0.0019 0.0007 0.0007
Echinococcus granulosus tar DNA binding protein 0.0132 0.0523 0.0523
Trypanosoma cruzi CYC2-like cyclin, putative 0.0489 0.2148 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0042 0.0113 0.0291
Trichomonas vaginalis cyclin B, putative 0.0062 0.0204 0.0949
Brugia malayi Calcitonin receptor-like protein seb-1 0.0404 0.1759 0.4723
Onchocerca volvulus 0.007 0.0241 0.1095
Trypanosoma cruzi hypothetical protein, conserved 0.0062 0.0204 0.0692
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0013 0.0059
Echinococcus multilocularis cyclins 0.0258 0.1093 0.1093
Toxoplasma gondii cyclin 4, putative 0.0062 0.0204 0.2442
Trichomonas vaginalis PIKK family atypical protein kinase 0.0072 0.0249 0.1158
Entamoeba histolytica hypothetical protein 0.007 0.0239 0.1003
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0059 0.0275
Entamoeba histolytica cyclin, domain containing protein 0.0062 0.0204 0.0836
Schistosoma mansoni hypothetical protein 0.0128 0.0502 0.0502
Brugia malayi Protein kinase domain containing protein 0.0179 0.0736 0.1966
Echinococcus multilocularis sterol regulatory element binding protein 0.0082 0.0295 0.0295
Trypanosoma cruzi target of rapamycin kinase 3 0.0072 0.0249 0.091
Echinococcus multilocularis G1:S specific cyclin D1 0.0062 0.0204 0.0204
Echinococcus granulosus cyclins 0.0062 0.0204 0.0204
Trypanosoma cruzi cyclin, putative 0.0489 0.2148 1
Entamoeba histolytica cyclin, putative 0.0489 0.2148 1
Echinococcus multilocularis cyclin dependent kinase 0.0179 0.0736 0.0736
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0042 0.0113 0.0113
Brugia malayi CHE-14 protein 0.0082 0.0295 0.0777
Echinococcus multilocularis mothers against decapentaplegic 5 0.0042 0.0113 0.0113
Schistosoma mansoni cyclin d 0.0062 0.0204 0.0204
Echinococcus multilocularis mothers against decapentaplegic 2 0.0019 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0276 0.1177 0.3159
Trichomonas vaginalis PIKK family atypical protein kinase 0.0067 0.0227 0.1059
Trichomonas vaginalis conserved hypothetical protein 0.0258 0.1093 0.509
Trypanosoma cruzi cyclin, putative 0.0489 0.2148 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0143 0.0668
Plasmodium falciparum cyclin 0.0258 0.1093 1
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0013 0.0059
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0075 0.0349
Schistosoma mansoni smad 0.0042 0.0113 0.0113
Echinococcus multilocularis oligomeric golgi complex subunit 3 0.0062 0.0204 0.0204
Leishmania major phosphatidylinositol 3-kinase, putative 0.003 0.0059 0.0155
Mycobacterium tuberculosis Probable hydrolase 0.007 0.0241 0.1226
Brugia malayi hypothetical protein 0.0062 0.0204 0.0531
Echinococcus granulosus cyclin t1 0.0062 0.0204 0.0204
Trichomonas vaginalis PIKK family atypical protein kinase 0.0091 0.0333 0.1551
Loa Loa (eye worm) hypothetical protein 0.0404 0.1759 0.4725
Brugia malayi Probable ClpP-like protease 0.0076 0.0265 0.0696
Schistosoma mansoni Smad4 0.0019 0.0007 0.0007
Trypanosoma cruzi cdc2-related kinase 1 0.0179 0.0736 0.3241
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.002 0.0013 0.0059
Schistosoma mansoni cyclin G 0.0062 0.0204 0.0204
Echinococcus granulosus TGF beta signal transducer SmadC 0.0042 0.0113 0.0113
Echinococcus multilocularis geminin 0.0493 0.2167 0.2167
Giardia lamblia GTOR 0.0091 0.0333 0.0666
Schistosoma mansoni serine/threonine protein kinase 0.0179 0.0736 0.0736
Loa Loa (eye worm) hypothetical protein 0.0489 0.2148 0.5773
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.007 0.0239 0.0239
Echinococcus granulosus ecdysone induced protein 78C 0.0022 0.0019 0.0019
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0022 0.0019 0.0033
Echinococcus granulosus neuropeptide s receptor 0.0908 0.4055 0.4055
Echinococcus multilocularis cyclin G2 0.0062 0.0204 0.0204
Trichomonas vaginalis PIKK family atypical protein kinase 0.0054 0.0165 0.0767
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.007 0.0241 0.0636
Toxoplasma gondii histone lysine methyltransferase SET1 0.0169 0.0688 0.8477
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0082 0.0295 0.0782
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0124 0.0322
Trichomonas vaginalis cyclin A, putative 0.0489 0.2148 1
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0076 0.0265 0.2139
Echinococcus multilocularis cyclin dependent kinase 5 0.0179 0.0736 0.0736
Loa Loa (eye worm) transcription factor SMAD2 0.0619 0.2738 0.7364
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0064 0.0212 0.0212
Echinococcus multilocularis transcription factor Dp 1 0.0037 0.0089 0.0089
Trichomonas vaginalis penicillin-binding protein, putative 0.007 0.0241 0.1122
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0022 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0489 0.2148 0.5773
Onchocerca volvulus 0.0023 0.0026 0.0092
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0128 0.0502 0.0502
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0143 0.0668
Echinococcus multilocularis GPCR, family 2 0.0128 0.0502 0.0502
Echinococcus granulosus cyclins 0.0258 0.1093 0.1093
Loa Loa (eye worm) hypothetical protein 0.007 0.0241 0.0636
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0124 0.0124
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0013 0.0059
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.003 0.0059 0.0059
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.0212 0.0731
Echinococcus multilocularis cyclin y 0.0062 0.0204 0.0204
Echinococcus granulosus cyclins 0.0258 0.1093 0.1093
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0091 0.0333 0.0333
Echinococcus granulosus Niemann Pick C1 protein 0.0274 0.1167 0.1167
Brugia malayi MH2 domain containing protein 0.0042 0.0113 0.0286
Giardia lamblia Kinase, CMGC CDK 0.0179 0.0736 0.2738
Echinococcus granulosus cyclin B3 1 0.0258 0.1093 0.1093
Echinococcus multilocularis tumor protein p63 0.0662 0.2935 0.2935
Loa Loa (eye worm) cyclin fold protein 1 variant b 0.0062 0.0204 0.0536
Schistosoma mansoni cpg binding protein 0.0094 0.0349 0.0349
Trypanosoma brucei cyclin 3 0.0062 0.0204 0.0692
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0022 0.0019 0.0019
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.005 0.0146 0.5524
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0143 0.0666
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.003 0.0059 0.0059
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0091 0.0333 0.1312
Echinococcus granulosus transcription factor btf3 0.0034 0.0075 0.0075
Trypanosoma cruzi cdc2-related kinase 3 0.0179 0.0736 0.3241
Mycobacterium tuberculosis Probable conserved lipoprotein 0.007 0.0241 0.1226
Trichomonas vaginalis cyclins, putative 0.0062 0.0204 0.0949
Trichomonas vaginalis conserved hypothetical protein 0.0082 0.0295 0.1374
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0019 0.0019
Schistosoma mansoni cyclins 0.0258 0.1093 0.1093
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0132 0.0523 0.1396
Plasmodium falciparum cyclin 1 0.0062 0.0204 0.156
Echinococcus multilocularis ecdysone induced protein 78C 0.0022 0.0019 0.0019
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0124 0.0317
Echinococcus multilocularis tar DNA binding protein 0.0132 0.0523 0.0523
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.007 0.0241 0.9104
Brugia malayi Cyclin, N-terminal domain containing protein 0.0062 0.0204 0.0531
Trypanosoma cruzi cyclin 9, putative 0.0062 0.0204 0.0692
Entamoeba histolytica cyclin, domain containing protein 0.0062 0.0204 0.0836
Trichomonas vaginalis PIKK family atypical protein kinase 0.0067 0.0227 0.1059
Toxoplasma gondii cyclin dependent kinase binding protein 0.0062 0.0204 0.2442
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0404 0.1759 0.4723
Brugia malayi nuclear receptor NHR-88 0.0022 0.0019 0.0033
Brugia malayi Cyclin, N-terminal domain containing protein 0.0489 0.2148 0.5771
Trypanosoma cruzi mitotic cyclin, putative 0.0062 0.0204 0.0692
Trypanosoma brucei mitotic cyclin 0.0062 0.0204 0.0692
Echinococcus multilocularis expressed conserved protein 0.018 0.074 0.074
Echinococcus granulosus Cyclin L1 0.0062 0.0204 0.0204
Plasmodium vivax cyclin dependent kinase binding protein, putative 0.0062 0.0204 0.236
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0008 0.0036
Loa Loa (eye worm) hypothetical protein 0.0023 0.0026 0.0058
Leishmania major cyclin 9, putative 0.0062 0.0204 0.0836
Echinococcus multilocularis neuropeptide s receptor 0.0908 0.4055 0.4055
Entamoeba histolytica cyclin C, putative 0.0062 0.0204 0.0836
Loa Loa (eye worm) hypothetical protein 0.0023 0.0026 0.0058
Loa Loa (eye worm) hypothetical protein 0.007 0.0241 0.0636
Loa Loa (eye worm) hypothetical protein 0.0023 0.0026 0.0058
Trichomonas vaginalis conserved hypothetical protein 0.0062 0.0204 0.0949
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0059 0.0275
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0013 0.0059
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0091 0.0333 0.1312
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0026 0.0053
Loa Loa (eye worm) CXXC zinc finger family protein 0.0089 0.0326 0.0865
Trypanosoma cruzi hypothetical protein, conserved 0.007 0.0241 0.0871
Echinococcus granulosus transcription factor Dp 1 0.0037 0.0089 0.0089
Trichomonas vaginalis PIKK family atypical protein kinase 0.0067 0.0227 0.1059
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0022 0.0019 0.0019
Schistosoma mansoni thyroid hormone receptor 0.0168 0.0686 0.0686
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.0489 0.2148 1
Echinococcus multilocularis cyclin A3 4 0.0062 0.0204 0.0204
Echinococcus granulosus cyclin G2 0.0062 0.0204 0.0204
Trichomonas vaginalis PIKK family atypical protein kinase 0.0067 0.0227 0.1059
Echinococcus multilocularis cyclin dependent kinase 1 0.0179 0.0736 0.0736
Trichomonas vaginalis PIKK family atypical protein kinase 0.0059 0.0188 0.0878
Onchocerca volvulus 0.0062 0.0204 0.0921
Trichomonas vaginalis cyclin D, putative 0.0258 0.1093 0.509
Brugia malayi CXXC zinc finger family protein 0.0089 0.0326 0.086
Echinococcus granulosus Protein patched homolog 1 0.0082 0.0295 0.0295
Loa Loa (eye worm) hypothetical protein 0.0232 0.0975 0.2615
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0022 0.0019 0.0033
Echinococcus granulosus dnaJ subfamily B 0.0403 0.1756 0.1756
Onchocerca volvulus Bile acid receptor homolog 0.0022 0.0019 0.0057
Trichomonas vaginalis cyclin B, putative 0.0489 0.2148 1
Echinococcus multilocularis cyclin b3 0.0258 0.1093 0.1093
Schistosoma mansoni hypothetical protein 0.0079 0.0282 0.0282
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.007 0.0241 0.1226
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0076 0.0265 1
Onchocerca volvulus Cyclin L homolog 0.0062 0.0204 0.0921
Trichomonas vaginalis PIKK family atypical protein kinase 0.0054 0.0167 0.0779
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0022 0.0019 0.0038
Echinococcus multilocularis cyclin dependent kinase 1 0.0179 0.0736 0.0736
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.007 0.0241 0.0632
Entamoeba histolytica cyclin, putative 0.0258 0.1093 0.5029
Trichomonas vaginalis PIKK family atypical protein kinase 0.0072 0.0249 0.1158
Echinococcus granulosus expressed conserved protein 0.018 0.074 0.074
Plasmodium vivax cyclin homologue, putative 0.0062 0.0204 0.236
Mycobacterium tuberculosis Probable lipase LipD 0.007 0.0241 0.1226
Mycobacterium tuberculosis Conserved protein 0.007 0.0241 0.1226
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0026 0.0053
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0091 0.0333 0.1446
Giardia lamblia G2/mitotic-specific cyclin B 0.0489 0.2148 1
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0064 0.0212 0.0874
Echinococcus granulosus smad 0.0042 0.0113 0.0113
Loa Loa (eye worm) hypothetical protein 0.0023 0.0027 0.006
Trypanosoma cruzi hypothetical protein, conserved 0.007 0.0241 0.0871
Loa Loa (eye worm) histone methyltransferase 0.0028 0.0046 0.0111
Trichomonas vaginalis PIKK family atypical protein kinase 0.0091 0.0333 0.1551
Plasmodium falciparum protein kinase 5 0.0179 0.0736 0.661
Onchocerca volvulus 0.0489 0.2148 1
Onchocerca volvulus 0.0089 0.0326 0.1491
Echinococcus granulosus cyclin G2 0.0062 0.0204 0.0204
Brugia malayi Smad1 0.0042 0.0113 0.0286
Trichomonas vaginalis cyclins, putative 0.0258 0.1093 0.509
Brugia malayi F/Y-rich N-terminus family protein 0.0027 0.0045 0.0102
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.0019 0.0033
Echinococcus multilocularis dnaJ subfamily B 0.0403 0.1756 0.1756
Loa Loa (eye worm) hypothetical protein 0.0128 0.0502 0.134
Loa Loa (eye worm) hypothetical protein 0.0062 0.0204 0.0536
Entamoeba histolytica hypothetical protein 0.0034 0.0075 0.0229
Echinococcus multilocularis cdk5 and abl1 enzyme substrate 1 0.0062 0.0204 0.0204
Schistosoma mansoni nuclear hormone receptor 0.0022 0.0019 0.0019
Brugia malayi MH1 domain containing protein 0.0042 0.0113 0.0286
Plasmodium vivax basic transcription factor 3b, putative 0.0034 0.0075 0.0511
Schistosoma mansoni cyclin l 0.0062 0.0204 0.0204
Schistosoma mansoni hypothetical protein 0.0128 0.0502 0.0502
Plasmodium vivax hypothetical protein, conserved 0.007 0.0241 0.2895
Brugia malayi hypothetical protein 0.007 0.0239 0.0627
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.0019 0.0033
Echinococcus granulosus cyclin 0.0062 0.0204 0.0204
Echinococcus granulosus cyclin dependent kinase 1 0.0179 0.0736 0.0736
Schistosoma mansoni tar DNA-binding protein 0.0132 0.0523 0.0523
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0028 0.0046 0.0046
Echinococcus multilocularis smad 0.0042 0.0113 0.0113
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.002 0.0013 0.0059
Echinococcus granulosus cyclin k 0.0062 0.0204 0.0204
Loa Loa (eye worm) MH1 domain-containing protein 0.0019 0.0007 0.0005
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0022 0.0019 0.0038
Echinococcus multilocularis cyclin B3 1 0.0258 0.1093 0.1093
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0019 0.0033
Echinococcus multilocularis cyclins 0.0258 0.1093 0.1093
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0091 0.0333 0.088
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0038 0.0092 0.0158
Schistosoma mansoni patched 1 0.0082 0.0295 0.0295
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0064 0.0212 0.0557
Trypanosoma brucei cyclin 9 0.0062 0.0204 0.0692
Trichomonas vaginalis cyclins, putative 0.0294 0.1258 0.5859
Echinococcus granulosus peptidase Clp S14 family 0.005 0.0146 0.0146
Brugia malayi MH1 domain containing protein 0.0023 0.0027 0.0055
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0022 0.0019 0.0038
Echinococcus multilocularis cyclins 0.0258 0.1093 0.1093
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0013 0.0059
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0091 0.0333 0.1312
Schistosoma mansoni tar DNA-binding protein 0.0132 0.0523 0.0523
Trichomonas vaginalis PIKK family atypical protein kinase 0.0061 0.0197 0.0919
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0042 0.0113 0.0113
Echinococcus multilocularis cyclins 0.0258 0.1093 0.1093
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0013 0.0059
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0179 0.0736 0.197
Toxoplasma gondii hypothetical protein 0.0026 0.0039 0.0393
Schistosoma mansoni Smad4 0.0042 0.0113 0.0113
Echinococcus granulosus oligomeric golgi complex subunit 3 0.0062 0.0204 0.0204
Trichomonas vaginalis D-aminoacylase, putative 0.007 0.0241 0.1122
Trichomonas vaginalis PIKK family atypical protein kinase 0.0067 0.0227 0.1059
Echinococcus multilocularis cyclin k 0.0062 0.0204 0.0204
Loa Loa (eye worm) MH2 domain-containing protein 0.0019 0.0007 0.0005
Trichomonas vaginalis cyclin B, putative 0.0258 0.1093 0.509
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0076 0.0265 0.3202
Schistosoma mansoni hypothetical protein 0.0079 0.0282 0.0282
Echinococcus granulosus cyclins 0.0258 0.1093 0.1093
Echinococcus granulosus cyclins 0.0258 0.1093 0.1093
Echinococcus granulosus G2:mitotic specific cyclin B3 0.0834 0.3717 0.3717
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0404 0.1759 0.4725
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0026 0.0134
Echinococcus granulosus cyclin dependent kinase 0.0179 0.0736 0.0736
Echinococcus granulosus sterol regulatory element binding protein 0.0082 0.0295 0.0295
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0059 0.0275
Echinococcus multilocularis Niemann Pick C1 protein 0.0192 0.0793 0.0793
Loa Loa (eye worm) hypothetical protein 0.0101 0.0379 0.1009
Loa Loa (eye worm) hypothetical protein 0.007 0.0241 0.0636
Echinococcus multilocularis Niemann Pick C1 protein 0.0274 0.1167 0.1167
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0143 0.0668
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0449 0.1966 1
Echinococcus multilocularis cyclins 0.0258 0.1093 0.1093
Trichomonas vaginalis cyclin B, putative 0.0062 0.0204 0.0949
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0143 0.0668
Loa Loa (eye worm) cyclin domain-containing protein 0.0834 0.3717 1
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0026 0.0994
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.007 0.0241 0.0241
Echinococcus multilocularis cyclin B 0.0489 0.2148 0.2148
Schistosoma mansoni hypothetical protein 0.0079 0.0282 0.0282
Echinococcus granulosus G1:S specific cyclin D1 0.0062 0.0204 0.0204
Trichomonas vaginalis cyclin D, putative 0.0258 0.1093 0.509
Trypanosoma cruzi cdc2-related kinase 3 0.0179 0.0736 0.3241
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0026 0.0994
Brugia malayi MH2 domain containing protein 0.0619 0.2738 0.7363
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0128 0.0502 0.1336
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0026 0.0994
Leishmania major mitotic cyclin, putative 0.0062 0.0204 0.0836
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0026 0.0994
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.007 0.0239 0.0239
Brugia malayi Cyclin, N-terminal domain containing protein 0.0834 0.3717 1
Schistosoma mansoni RAR-like nuclear receptor 0.0022 0.0019 0.0019
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0059 0.0275
Brugia malayi latrophilin 2 splice variant baaae 0.0276 0.1177 0.3155
Echinococcus granulosus mixed lineage leukemia protein mll 0.0022 0.0021 0.0021
Trypanosoma brucei hypothetical protein, conserved 0.007 0.0241 0.0871
Loa Loa (eye worm) hypothetical protein 0.0177 0.0727 0.1946
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0189 0.078 0.078
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0064 0.0212 0.0212
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0022 0.0021 0.0021
Brugia malayi MH1 domain containing protein 0.0023 0.0027 0.0055
Echinococcus granulosus mothers against decapentaplegic 2 0.0019 0.0007 0.0007
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0026 0.0994
Echinococcus granulosus cpg binding protein 0.0094 0.0349 0.0349
Brugia malayi TAR-binding protein 0.0132 0.0523 0.1392
Schistosoma mansoni hypothetical protein 0.0276 0.1177 0.1177
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0026 0.0994
Trichomonas vaginalis cyclin B, putative 0.0489 0.2148 1
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0013 0.0059
Mycobacterium tuberculosis Probable esterase LipL 0.007 0.0241 0.1226
Trichomonas vaginalis PIKK family atypical protein kinase 0.0072 0.0249 0.1158
Trypanosoma brucei cdc2-related kinase 3 0.0179 0.0736 0.3241
Brugia malayi MH1 domain containing protein 0.0042 0.0113 0.0286
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0043 0.0116 0.0272
Schistosoma mansoni smad1 5 8 and 0.0042 0.0113 0.0113
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0022 0.0019 0.0038
Echinococcus multilocularis cyclin 0.0062 0.0204 0.0204
Schistosoma mansoni hypothetical protein 0.0403 0.1756 0.1756
Loa Loa (eye worm) hypothetical protein 0.0192 0.0793 0.2123
Brugia malayi Cyclin, N-terminal domain containing protein 0.0062 0.0204 0.0531
Schistosoma mansoni retinoic acid receptor RXR 0.0022 0.0019 0.0019
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0022 0.0019 0.0038
Trichomonas vaginalis PIKK family atypical protein kinase 0.0077 0.0273 0.1271
Schistosoma mansoni hypothetical protein 0.0128 0.0502 0.0502
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0022 0.0019 0.0019
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0022 0.0019 0.0019
Echinococcus multilocularis cyclins 0.0258 0.1093 0.1093
Echinococcus granulosus cyclins 0.0258 0.1093 0.1093
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0076 0.0265 0.3202
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0091 0.0333 0.1446
Trichomonas vaginalis PIKK family atypical protein kinase 0.0054 0.0167 0.0779
Loa Loa (eye worm) MH2 domain-containing protein 0.0619 0.2738 0.7364
Echinococcus multilocularis protein patched 0.0082 0.0295 0.0295
Toxoplasma gondii target of rapamycin (TOR), putative 0.0067 0.0227 0.2739
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0146 0.0588 0.0588

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.