Detailed information for compound 68036

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 478.966 | Formula: C24H31ClN2O6
  • H donors: 1 H acceptors: 2 LogP: 2.56 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCO/C(=C/1\C(=NC(=C(C1c1ccccc1Cl)C(=O)OC)C)COCCN1CCOCC1)/O
  • InChi: 1S/C24H31ClN2O6/c1-4-33-24(29)22-19(15-32-14-11-27-9-12-31-13-10-27)26-16(2)20(23(28)30-3)21(22)17-7-5-6-8-18(17)25/h5-8,21,29H,4,9-15H2,1-3H3/b24-22+
  • InChiKey: BLMJXHPYSCWCJY-ZNTNEXAZSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii pyruvate kinase PyK1 0.0036 0.0211 0.1061
Echinococcus granulosus phd:f box containing protein 0.0032 0.0168 0.0315
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0308 0.0858
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0067 0.0578 0.1542
Mycobacterium leprae Probable lipase LipE 0.0035 0.0203 0.0113
Echinococcus granulosus carbonic anhydrase 0.0165 0.1739 0.3383
Trypanosoma brucei DNA polymerase IV, putative 0.0044 0.0308 0.0858
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.0509 0.1723
Trichomonas vaginalis pyruvate kinase, putative 0.0036 0.0211 0.0336
Echinococcus multilocularis carbonic anhydrase 0.0165 0.1739 0.1733
Schistosoma mansoni caspase-3 (C14 family) 0.0114 0.1129 0.3855
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0312 0.3471 0.6311
Giardia lamblia Flap structure-specific endonuclease 0.0028 0.0119 0.0324
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0308 0.0858
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0034 0.019 0.0298
Entamoeba histolytica phosphofructokinase, putative 0.0116 0.116 0.3287
Schistosoma mansoni caspase-7 (C14 family) 0.0114 0.1129 0.3855
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.0362 0.0625
Trypanosoma brucei DNA polymerase kappa, putative 0.0033 0.0183 0.0508
Schistosoma mansoni family M1 non-peptidase homologue (M01 family) 0.0022 0.005 0.0149
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0214 0.1074
Loa Loa (eye worm) hypothetical protein 0.0061 0.0509 0.09
Plasmodium vivax 6-phosphofructokinase, putative 0.0031 0.0161 0.08
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0308 0.0858
Mycobacterium ulcerans glutaminase 0.0265 0.2919 1
Schistosoma mansoni phosphatidylserine receptor 0.0032 0.0168 0.0554
Schistosoma mansoni 6-phosphofructokinase 0.0116 0.116 0.3959
Entamoeba histolytica pyruvate kinase, putative 0.0025 0.0084 0.0163
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0315 0.1057
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0051 0.0391 0.0751
Loa Loa (eye worm) hypothetical protein 0.0032 0.0168 0.0262
Schistosoma mansoni tyrosine kinase 0.0159 0.1669 0.5708
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.0509 0.1723
Trypanosoma brucei RNA helicase, putative 0.01 0.0975 0.2713
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0116 0.116 0.3174
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0043 0.0297 0.1508
Schistosoma mansoni tyrosine kinase 0.0085 0.0789 0.2688
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.002 0.0033 0.005
Trypanosoma brucei unspecified product 0.0037 0.0225 0.0627
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0059 0.0482 0.0929
Echinococcus granulosus 6 phosphofructokinase 0.0116 0.116 0.2252
Entamoeba histolytica hypothetical protein 0.002 0.0033 0.0013
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0043 0.0297 0.0494
Echinococcus multilocularis caspase 8 0.0043 0.0297 0.0291
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0039 0.0033
Toxoplasma gondii exonuclease III APE 0.002 0.0028 0.011
Loa Loa (eye worm) hypothetical protein 0.0035 0.0203 0.0328
Trichomonas vaginalis flap endonuclease-1, putative 0.0028 0.0119 0.0167
Echinococcus granulosus neuropeptide receptor A26 0.0453 0.5125 1
Echinococcus multilocularis neuropeptide s receptor 0.0453 0.5125 0.5122
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0061 0.0509 0.2604
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0134 0.1376 0.137
Schistosoma mansoni inositol monophosphatase 0.0036 0.0214 0.0711
Mycobacterium leprae Probable phosphoglycerate kinase Pgk 0.0182 0.1934 0.5919
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.012 0.1205 0.234
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.002 0.0033 0.0009
Echinococcus multilocularis Regulator of G protein signaling 20 0.002 0.0033 0.0026
Trypanosoma cruzi metacaspase 5, putative 0.0043 0.0297 0.0755
Brugia malayi hypothetical protein 0.002 0.0033 0.0009
Plasmodium falciparum metacaspase-like protein 0.0043 0.0297 0.1508
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0153 0.1591 0.4427
Mycobacterium ulcerans DNA polymerase IV 0.0044 0.0308 0.0969
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0036 0.0211 0.0765
Brugia malayi hypothetical protein 0.0473 0.5367 1
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.002 0.0033 0.0009
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0043 0.0297 0.1508
Echinococcus granulosus Regulator of G protein signaling 20 0.002 0.0033 0.005
Echinococcus granulosus carbonic anhydrase II 0.0165 0.1739 0.3383
Echinococcus granulosus pyruvate kinase 0.0036 0.0211 0.0399
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.002 0.0028 0.0061
Echinococcus granulosus regulator of G protein signaling 7 0.002 0.0033 0.005
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0203 0.0491
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0023 0.0057 0.008
Trypanosoma cruzi metacaspase, putative 0.0043 0.0297 0.0755
Giardia lamblia Fructose-bisphosphate aldolase 0.0312 0.3471 1
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0116 0.116 0.4725
Brugia malayi PXA domain containing protein 0.002 0.0033 0.0009
Toxoplasma gondii LsmAD domain-containing protein 0.0024 0.008 0.0378
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0203 0.0731
Toxoplasma gondii phosphoglycerate kinase PGKI 0.0182 0.1934 1
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0214 0.0521
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0034 0.019 0.0456
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0203 0.0321
Schistosoma mansoni hypothetical protein 0.0052 0.0398 0.1345
Entamoeba histolytica hypothetical protein 0.002 0.0033 0.0013
Echinococcus granulosus JmjC domain containing protein 4 0.0032 0.0168 0.0315
Echinococcus multilocularis 0.0049 0.0372 0.0366
Onchocerca volvulus 0.0061 0.0509 0.0862
Leishmania major pyruvate kinase 0.0036 0.0211 0.0514
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0182 0.1934 0.3494
Loa Loa (eye worm) hypothetical protein 0.0083 0.0769 0.1387
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0045 0.0326 0.0835
Brugia malayi glutaminase DH11.1 0.0265 0.2919 0.5414
Loa Loa (eye worm) hypothetical protein 0.002 0.0033 0.0009
Loa Loa (eye worm) carbonic anhydrase 3 0.0165 0.1739 0.3204
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0223 0.2423 1
Echinococcus granulosus beta-adrenergic receptor kinase 0.002 0.0033 0.005
Schistosoma mansoni d-amino acid oxidase 0.0179 0.19 0.65
Mycobacterium tuberculosis Probable phosphoglycerate kinase Pgk 0.0182 0.1934 0.7958
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0165 0.1739 0.3204
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0203 0.0328
Echinococcus granulosus muscleblind protein 0.0145 0.15 0.2918
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0057 0.0157
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0034 0.019 0.0184
Loa Loa (eye worm) inositol-1 0.0036 0.0214 0.0348
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0032 0.0168 0.0393
Trypanosoma brucei phosphoglycerate kinase 0.0182 0.1934 0.5382
Trypanosoma cruzi metacaspase, putative 0.0043 0.0297 0.0755
Brugia malayi Flap endonuclease-1 0.0028 0.0119 0.0171
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0315 0.0601
Plasmodium falciparum pyruvate kinase 0.0036 0.0211 0.1061
Schistosoma mansoni aldehyde dehydrogenase 0.0065 0.0556 0.1885
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.008 0.0145
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0308 0.0858
Brugia malayi A-kinase anchor protein 10, precursor 0.002 0.0033 0.0009
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.0556 0.1825
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0203 0.0321
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0134 0.1376 0.2675
Echinococcus multilocularis thyroid hormone receptor alpha 0.0145 0.1503 0.1498
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0045 0.0326 0.0907
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0214 0.0404
Loa Loa (eye worm) hypothetical protein 0.0032 0.0168 0.0262
Echinococcus granulosus carbonic anhydrase 0.0165 0.1739 0.3383
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0034 0.019 0.0184
Loa Loa (eye worm) CYP4Cod1 0.0021 0.0035 0.0013
Loa Loa (eye worm) hypothetical protein 0.0033 0.0183 0.0289
Treponema pallidum methylgalactoside ABC transporter, periplasmic galactose-binding protein (mglB-1) 0.0285 0.315 0.9069
Echinococcus granulosus expressed protein 0.0399 0.449 0.876
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0165 0.1739 0.3204
Brugia malayi phosphofructokinase 0.0116 0.116 0.2119
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0039 0.0064
Trypanosoma cruzi DNA polymerase kappa, putative 0.0044 0.0308 0.0786
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0033 0.0008
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0065 0.0556 0.2203
Toxoplasma gondii aldehyde dehydrogenase 0.0065 0.0556 0.2848
Schistosoma mansoni survival motor neuron protein 0.0052 0.0398 0.1345
Schistosoma mansoni jumonji domain containing protein 0.012 0.1205 0.4113
Loa Loa (eye worm) hypothetical protein 0.002 0.0033 0.0009
Brugia malayi jmjC domain containing protein 0.0032 0.0168 0.0262
Mycobacterium ulcerans lipase LipD 0.0035 0.0203 0.0606
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.012 0.1205 0.1199
Loa Loa (eye worm) hypothetical protein 0.0048 0.0362 0.0625
Schistosoma mansoni hypothetical protein 0.004 0.0263 0.0878
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0032 0.0168 0.0393
Loa Loa (eye worm) cytochrome P450 family protein 0.0021 0.0035 0.0013
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0308 0.0858
Onchocerca volvulus 0.004 0.0263 0.041
Onchocerca volvulus 0.0483 0.5483 1
Plasmodium vivax multidomain scavenger receptor, putative 0.0021 0.0039 0.017
Schistosoma mansoni aldehyde dehydrogenase 0.0065 0.0556 0.1885
Trichomonas vaginalis set domain proteins, putative 0.0483 0.5483 1
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0203 0.0565
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0033 0.0088
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0114 0.1129 0.1123
Trypanosoma brucei PAB1-binding protein , putative 0.0024 0.008 0.0222
Brugia malayi regulator of G-protein signaling rgs-7 0.002 0.0033 0.0009
Loa Loa (eye worm) runx1 0.0059 0.0491 0.0867
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0032 0.0168 0.0837
Echinococcus granulosus apoptotic protease activating factor 1 0.004 0.0263 0.05
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0312 0.3471 1
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0065 0.0556 0.148
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0312 0.3471 0.6311
Schistosoma mansoni ap endonuclease 0.002 0.0028 0.0073
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0028 0.011
Brugia malayi jmjC domain containing protein 0.012 0.1205 0.2203
Schistosoma mansoni hypothetical protein 0.0021 0.0039 0.0112
Echinococcus multilocularis regulator of G protein signaling 0.002 0.0033 0.0026
Echinococcus multilocularis jumonji domain containing 1A 0.0032 0.0168 0.0161
Loa Loa (eye worm) hypothetical protein 0.0145 0.15 0.2757
Brugia malayi Cytochrome P450 family protein 0.0021 0.0035 0.0013
Trypanosoma brucei Aminopeptidase M1, putative 0.0034 0.019 0.053
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.0509 0.1723
Schistosoma mansoni thyroid hormone receptor 0.0145 0.1503 0.5139
Schistosoma mansoni jumonji/arid domain-containing protein 0.012 0.1205 0.4113
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0043 0.0297 0.0494
Entamoeba histolytica aminopeptidase, putative 0.0034 0.019 0.0472
Brugia malayi Peptidase family M1 containing protein 0.0034 0.019 0.0304
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0203 0.0674
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0315 0.0601
Echinococcus multilocularis caspase 3 0.0071 0.0623 0.0617
Mycobacterium ulcerans hypothetical protein 0.0035 0.0203 0.0606
Onchocerca volvulus Pyruvate kinase homolog 0.0036 0.0211 0.0315
Loa Loa (eye worm) jmjC domain-containing protein 0.0032 0.0168 0.0262
Echinococcus multilocularis epidermal growth factor receptor 0.0086 0.08 0.0794
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0031 0.0161 0.0386
Loa Loa (eye worm) 6-phosphofructokinase 0.0116 0.116 0.2119
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0028 0.0119 0.0255
Entamoeba histolytica phosphofructokinase, putative 0.0116 0.116 0.3287
Trichomonas vaginalis phosphofructokinase, putative 0.0116 0.116 0.2074
Loa Loa (eye worm) hypothetical protein 0.0043 0.0297 0.0504
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0022 0.005 0.0062
Plasmodium falciparum phosphoglycerate kinase 0.0182 0.1934 1
Brugia malayi Pyruvate kinase, M2 isozyme 0.0036 0.0211 0.0343
Schistosoma mansoni loxhd1 0.0021 0.0039 0.0112
Loa Loa (eye worm) pyruvate kinase-PB 0.0025 0.0084 0.0105
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0203 0.0606
Loa Loa (eye worm) pyruvate kinase 0.0036 0.0211 0.0343
Brugia malayi hypothetical protein 0.004 0.0263 0.0439
Echinococcus multilocularis lysine specific demethylase 5A 0.012 0.1205 0.1199
Trypanosoma brucei pyruvate kinase 1 0.0036 0.0211 0.0588
Plasmodium vivax flap endonuclease 1, putative 0.0028 0.0119 0.0583
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0036 0.0214 0.0975
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0065 0.0556 0.1072
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0297 0.1508
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0312 0.3471 0.6311
Trichomonas vaginalis pyruvate kinase, putative 0.0036 0.0211 0.0336
Echinococcus multilocularis survival motor neuron protein 1 0.0253 0.2768 0.2763
Brugia malayi Doublecortin family protein 0.0021 0.0039 0.0021
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0033 0.0008
Echinococcus granulosus epidermal growth factor receptor 0.0159 0.1669 0.3247
Loa Loa (eye worm) hypothetical protein 0.0165 0.1739 0.3204
Brugia malayi Pre-SET motif family protein 0.0424 0.4792 0.8923
Trypanosoma cruzi Aminopeptidase M1, putative 0.0034 0.019 0.0456
Echinococcus multilocularis muscleblind protein 1 0.0145 0.15 0.1494
Trypanosoma cruzi DNA polymerase kappa, putative 0.0044 0.0308 0.0786
Onchocerca volvulus 0.0052 0.0398 0.0659
Loa Loa (eye worm) hypothetical protein 0.004 0.0263 0.0439
Leishmania major DNA polymerase kappa, putative 0.0023 0.0057 0.008
Brugia malayi 6-phosphofructokinase 0.0116 0.116 0.2119
Schistosoma mansoni regulator of G protein signaling 0.002 0.0033 0.0088
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0203 0.0384
Plasmodium vivax metacaspase 1, putative 0.0043 0.0297 0.1508
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0203 0.0731
Brugia malayi Inositol-1 0.0036 0.0214 0.0348
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0028 0.0021
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0161 0.0244
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0033 0.0008
Loa Loa (eye worm) glutaminase 2 0.0265 0.2919 0.5414
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0203 0.0731
Loa Loa (eye worm) hypothetical protein 0.0021 0.0039 0.0021
Plasmodium vivax JmjC domain containing protein 0.0032 0.0168 0.0837
Echinococcus multilocularis lysine specific demethylase 6a 0.0032 0.0168 0.0161
Schistosoma mansoni tyrosine kinase 0.0051 0.0391 0.132
Echinococcus multilocularis pyruvate kinase 0.0036 0.0211 0.0205
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0034 0.019 0.0456
Mycobacterium ulcerans beta-lactamase 0.0035 0.0203 0.0606
Schistosoma mansoni regulator of G protein signaling 0.002 0.0033 0.0088
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.007 0.0613 0.0606
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0315 0.1057
Trypanosoma brucei metacaspase MCA3 0.0043 0.0297 0.0828
Echinococcus multilocularis regulator of G protein signaling 3 0.002 0.0033 0.0026
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.0362 0.0625
Onchocerca volvulus 0.0034 0.019 0.0277
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0051 0.0391 0.0385
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0308 0.0858
Loa Loa (eye worm) hypothetical protein 0.0035 0.0203 0.0328
Loa Loa (eye worm) hypothetical protein 0.0182 0.1934 0.3569
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0315 0.0308
Schistosoma mansoni axis inhibition protein axin 0.002 0.0033 0.0088
Leishmania major hypothetical protein, conserved 0.0024 0.008 0.0145
Mycobacterium tuberculosis Probable D-amino acid oxidase Aao 0.0164 0.1724 0.7081
Brugia malayi hypothetical protein 0.002 0.0033 0.0009
Brugia malayi Pyruvate kinase, muscle isozyme 0.0036 0.0211 0.0343
Schistosoma mansoni hypothetical protein 0.0033 0.0181 0.0599
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0203 0.0328
Brugia malayi jmjC domain containing protein 0.0032 0.0168 0.0262
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0043 0.0297 0.0494
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0034 0.019 0.0184
Giardia lamblia DINP protein human, muc B family 0.0023 0.0057 0.0144
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0165 0.1739 0.3204
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0214 0.0521
Loa Loa (eye worm) RGS-3 protein 0.002 0.0033 0.0009
Trypanosoma cruzi aminopeptidase, putative 0.0034 0.019 0.0456
Mycobacterium ulcerans DNA polymerase IV 0.0044 0.0308 0.0969
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0214 0.0341
Echinococcus multilocularis Polycystic kidney disease protein 0.0021 0.0039 0.0033
Mycobacterium tuberculosis Conserved protein 0.0035 0.0203 0.0731
Leishmania major cytochrome p450-like protein 0.0021 0.0035 0.002
Trypanosoma cruzi cytochrome P450, putative 0.0021 0.0035 0.002
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0043 0.0297 0.1508
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0052 0.0398 0.0694
Trypanosoma brucei DNA polymerase kappa, putative 0.0033 0.0183 0.0508
Plasmodium falciparum JmjC domain-containing protein, putative 0.0032 0.0168 0.0837
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0297 0.0494
Brugia malayi Cytochrome P450 family protein 0.0021 0.0035 0.0013
Trypanosoma brucei pyruvate kinase 1, putative 0.0036 0.0211 0.0588
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0039 0.0033
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.008 0.0145
Loa Loa (eye worm) PXA domain-containing protein 0.002 0.0033 0.0009
Giardia lamblia Pyruvate kinase 0.0036 0.0211 0.059
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0061 0.0509 0.0502
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0114 0.1129 0.2193
Echinococcus multilocularis pyruvate kinase 0.0028 0.0123 0.0116
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0181 0.0287
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0043 0.0297 0.0998
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0045 0.0326 0.0835
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0039 0.0064
Schistosoma mansoni axis inhibition protein axin 0.002 0.0033 0.0088
Onchocerca volvulus Cell death protein 3 homolog 0.0083 0.0769 0.134
Echinococcus granulosus RUN 0.0021 0.0039 0.0064
Schistosoma mansoni caspase-7 (C14 family) 0.0083 0.0769 0.2616
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.008 0.0378
Loa Loa (eye worm) hypothetical protein 0.0021 0.0039 0.0021
Leishmania major ATP-dependent phosphofructokinase 0.0116 0.116 0.3174
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0297 0.0494
Entamoeba histolytica Flap nuclease, putative 0.0028 0.0119 0.0265
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0323 0.3593 1
Loa Loa (eye worm) doublecortin family protein 0.0021 0.0039 0.0021
Schistosoma mansoni z-protein (S1r protein) 0.002 0.0033 0.0088
Leishmania major carbonic anhydrase-like protein 0.0165 0.1739 0.4798
Leishmania major pyruvate kinase 0.0036 0.0211 0.0514
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.002 0.0033 0.0088
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0312 0.3471 0.6311
Plasmodium vivax phosphoglycerate kinase, putative 0.0182 0.1934 1
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0165 0.1739 0.5947
Echinococcus multilocularis RUN 0.0021 0.0039 0.0033
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0043 0.0297 0.0494
Mycobacterium tuberculosis Conserved protein 0.0035 0.0203 0.0731
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0203 0.1019
Onchocerca volvulus 0.0473 0.5367 0.9787
Plasmodium falciparum flap endonuclease 1 0.0028 0.0119 0.0583
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.002 0.0033 0.0008
Echinococcus granulosus histone lysine methyltransferase setb 0.0061 0.0509 0.098
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0033 0.0008
Echinococcus granulosus lysine specific demethylase 5A 0.012 0.1205 0.234
Brugia malayi Cell death protein 3 precursor 0.0083 0.0769 0.1387
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.0315 0.0537
Mycobacterium ulcerans pyruvate kinase 0.0036 0.0211 0.0634
Echinococcus granulosus axis inhibition protein axin 0.002 0.0033 0.005
Loa Loa (eye worm) aminopeptidase N 0.0034 0.019 0.0304
Schistosoma mansoni regulator of G protein signaling 0.002 0.0033 0.0088
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0214 0.0595
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0116 0.116 0.3287
Brugia malayi hypothetical protein 0.0021 0.0039 0.0021
Echinococcus granulosus Polycystic kidney disease protein 0.0021 0.0039 0.0064
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0308 0.0858
Leishmania major hypothetical protein, conserved 0.0032 0.0168 0.0393
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0034 0.019 0.0359
Echinococcus multilocularis phd:f box containing protein 0.0032 0.0168 0.0161
Echinococcus multilocularis axis inhibition protein axin 0.002 0.0033 0.0026
Loa Loa (eye worm) hypothetical protein 0.0165 0.1739 0.3204
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0153 0.1589 0.6517
Loa Loa (eye worm) hypothetical protein 0.002 0.0033 0.0009
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0116 0.116 0.3322
Schistosoma mansoni tyrosine kinase 0.0086 0.08 0.2724
Brugia malayi polk-prov protein 0.0033 0.0183 0.0289
Trypanosoma cruzi metacaspase, putative 0.0043 0.0297 0.0755
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.0315 0.0537
Plasmodium falciparum carbonic anhydrase 0.0165 0.1739 0.8986
Echinococcus granulosus jumonji domain containing 1A 0.0032 0.0168 0.0315
Mycobacterium ulcerans phosphoglycerate kinase 0.0182 0.1934 0.6593
Brugia malayi jmjC domain containing protein 0.0032 0.0168 0.0262
Echinococcus multilocularis flap endonuclease 1 0.0028 0.0119 0.0112
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0028 0.011
Mycobacterium ulcerans D-amino acid oxidase Aao 0.0179 0.19 0.6475
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0203 0.0606
Echinococcus multilocularis aminopeptidase N 0.0034 0.019 0.0184
Schistosoma mansoni jumonji domain containing protein 0.0032 0.0168 0.0554
Schistosoma mansoni hypothetical protein 0.0134 0.1376 0.4702
Plasmodium falciparum metacaspase 1 0.0043 0.0297 0.1508
Schistosoma mansoni lozenge 0.0059 0.0491 0.1662
Echinococcus multilocularis regulator of G protein signaling 7 0.002 0.0033 0.0026
Plasmodium vivax SET domain protein, putative 0.0061 0.0509 0.2604
Echinococcus granulosus phosphoglycerate kinase 1 0.0182 0.1934 0.3765
Trypanosoma brucei metacaspase 5, putative 0.0043 0.0297 0.0828
Brugia malayi Regulator of G protein signaling domain containing protein 0.002 0.0033 0.0009
Schistosoma mansoni carbonic anhydrase 0.0165 0.1739 0.5947
Brugia malayi Phosphoglycerate kinase 0.0067 0.0578 0.103
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0424 0.4792 0.8923
Brugia malayi regulator of G-protein signaling egl-10 0.002 0.0033 0.0009
Loa Loa (eye worm) hypothetical protein 0.0165 0.1739 0.3204
Plasmodium vivax 6-phosphofructokinase, putative 0.0031 0.0161 0.08
Toxoplasma gondii phosphoglycerate kinase PGKII 0.0182 0.1934 1
Trypanosoma brucei phosphoglycerate kinase 0.0067 0.0578 0.1608
Loa Loa (eye worm) jmjC domain-containing protein 0.0032 0.0168 0.0262
Echinococcus multilocularis carbonic anhydrase II 0.0165 0.1739 0.1733
Schistosoma mansoni carbonic anhydrase-related 0.0165 0.1739 0.5947
Echinococcus multilocularis phosphoglycerate kinase 1 0.0182 0.1934 0.1928
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0203 0.0113
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0165 0.1739 0.3204
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0045 0.0326 0.0835
Echinococcus multilocularis 6 phosphofructokinase 0.0116 0.116 0.1154
Entamoeba histolytica phosphoglycerate kinase, putative 0.0182 0.1934 0.5536
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0031 0.0161 0.08
Brugia malayi beta-lactamase family protein 0.0035 0.0203 0.0328
Echinococcus multilocularis neuropeptide receptor A26 0.0453 0.5125 0.5122
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0203 0.0321
Trichomonas vaginalis glutaminase, putative 0.0265 0.2919 0.5299
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0315 0.0308
Trypanosoma cruzi 3-phosphoglycerate kinase, glycosomal 0.0067 0.0578 0.1542
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0323 0.3593 1
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0032 0.0168 0.0161
Loa Loa (eye worm) hypothetical protein 0.0145 0.15 0.2757
Treponema pallidum phosphoglycerate kinase 0.0182 0.1934 0.5536
Schistosoma mansoni inositol monophosphatase 0.0036 0.0214 0.0711
Loa Loa (eye worm) hypothetical protein 0.0032 0.0168 0.0262
Loa Loa (eye worm) phosphofructokinase 0.0116 0.116 0.2119
Schistosoma mansoni protein phosphatase 2C 0.0032 0.0168 0.0554
Echinococcus granulosus neuropeptide s receptor 0.0453 0.5125 1
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0028 0.0119 0.0255
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0055 0.0443 0.1163
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0161 0.0244
Echinococcus granulosus pyruvate kinase 0.0036 0.0211 0.0399
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.008 0.0378
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0182 0.1934 0.5345
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0308 0.0858
Trypanosoma brucei Metacaspase-4 0.0043 0.0297 0.0828
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0165 0.1739 0.3204
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0126 0.1276 0.248
Echinococcus multilocularis caspase 0.0114 0.1129 0.1123
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0031 0.0161 0.0386
Echinococcus multilocularis axis inhibition protein axin 0.002 0.0033 0.0026
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0031 0.0161 0.08
Plasmodium falciparum LCCL domain-containing protein 0.0021 0.0039 0.017
Leishmania major phosphoglycerate kinase C, glycosomal 0.0182 0.1934 0.5345
Entamoeba histolytica phosphofructokinase, putative 0.0116 0.116 0.3287
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0033 0.0008
Toxoplasma gondii hypothetical protein 0.0052 0.0405 0.2064
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0312 0.3471 0.6311
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0031 0.0161 0.08
Brugia malayi Pre-SET motif family protein 0.0061 0.0509 0.09
Brugia malayi Peptidase family M1 containing protein 0.0034 0.019 0.0304
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0034 0.019 0.0184
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0034 0.019 0.0631
Trypanosoma brucei carbonic anhydrase-like protein 0.0165 0.1739 0.4838
Schistosoma mansoni phosphoglycerate kinase 0.0182 0.1934 0.6618
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0043 0.0297 0.0504
Schistosoma mansoni polycystin 1-related 0.0021 0.0039 0.0112
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0067 0.0578 0.1542
Loa Loa (eye worm) hypothetical protein 0.0022 0.005 0.0041
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0023 0.0057 0.0119
Trypanosoma brucei DNA polymerase IV, putative 0.0037 0.0225 0.0627
Toxoplasma gondii hypothetical protein 0.0165 0.1739 0.8986
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.002 0.0033 0.0088
Plasmodium vivax ataxin-2 like protein, putative 0.0024 0.008 0.0378
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0028 0.0119 0.0332
Echinococcus multilocularis regulator of G protein signaling 3 0.002 0.0033 0.0026
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0116 0.116 0.3227
Schistosoma mansoni carbonic anhydrase-related 0.0165 0.1739 0.5947
Loa Loa (eye worm) hypothetical protein 0.0179 0.19 0.3505
Trypanosoma brucei phosphoglycerate kinase, putative 0.0067 0.0578 0.1608
Leishmania major mitochondrial DNA polymerase beta 0.0323 0.3593 1
Schistosoma mansoni tyrosine kinase 0.0085 0.0789 0.2688
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0203 0.0731
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0061 0.0509 0.1723
Loa Loa (eye worm) jmjC domain-containing protein 0.012 0.1205 0.2203
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0043 0.0297 0.0494
Schistosoma mansoni regulator of G protein signaling 0.002 0.0033 0.0088
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0165 0.1739 0.3204
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.007 0.0613 0.208
Loa Loa (eye worm) hypothetical protein 0.0253 0.2768 0.5132
Loa Loa (eye worm) flap endonuclease-1 0.0028 0.0119 0.0171
Chlamydia trachomatis phosphoglycerate kinase 0.0182 0.1934 1
Schistosoma mansoni rab6-interacting 0.0021 0.0039 0.0112
Trypanosoma cruzi DNA polymerase kappa, putative 0.0044 0.0308 0.0786
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0067 0.0578 0.1542
Mycobacterium ulcerans hypothetical protein 0.017 0.1794 0.6109
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0153 0.1589 0.4761
Loa Loa (eye worm) hypothetical protein 0.0022 0.005 0.0041
Trichomonas vaginalis DNA polymerase eta, putative 0.0044 0.0308 0.0514
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0203 0.0491
Onchocerca volvulus Pyruvate kinase homolog 0.0036 0.0211 0.0315
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.0556 0.1825
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0057 0.0465 0.0818
Plasmodium vivax pyruvate kinase, putative 0.0036 0.0211 0.1061
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0165 0.1739 0.3204
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0061 0.0509 0.0502
Schistosoma mansoni carbonic anhydrase-related 0.0165 0.1739 0.5947
Loa Loa (eye worm) hypothetical protein 0.002 0.0033 0.0009
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0161 0.0244
Echinococcus granulosus insulin receptor 0.0051 0.0391 0.0751
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0034 0.019 0.0298
Leishmania major metacaspase, putative 0.0043 0.0297 0.0755
Schistosoma mansoni lipoxygenase 0.0088 0.0829 0.2824
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0312 0.3471 0.6311
Echinococcus granulosus epidermal growth factor receptor 0.0086 0.08 0.155
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0032 0.0168 0.0315
Echinococcus multilocularis dna polymerase kappa 0.0044 0.0308 0.0302
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0161 0.0244
Onchocerca volvulus 0.0035 0.0203 0.0301
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.007 0.0613 0.1095
Echinococcus multilocularis epidermal growth factor receptor 0.0159 0.1669 0.1663
Echinococcus granulosus survival motor neuron protein 1 0.0253 0.2768 0.5395
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0034 0.019 0.0359
Giardia lamblia Phosphoglycerate kinase 0.0182 0.1934 0.5563
Trypanosoma brucei cytochrome P450, putative 0.0021 0.0035 0.0098
Wolbachia endosymbiont of Brugia malayi phosphoglycerate kinase 0.0182 0.1934 1
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0032 0.017 0.0591
Brugia malayi jmjC domain containing protein 0.0032 0.0168 0.0262
Echinococcus multilocularis apoptotic protease activating factor 1 0.004 0.0263 0.0256
Trichomonas vaginalis phosphofructokinase, putative 0.0116 0.116 0.2074
Schistosoma mansoni pyruvate kinase 0.0036 0.0211 0.0702
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0034 0.019 0.0359
Brugia malayi hypothetical protein 0.0021 0.0039 0.0021
Trypanosoma brucei DNA polymerase IV, putative 0.0044 0.0308 0.0858
Schistosoma mansoni 6-phosphofructokinase 0.0116 0.116 0.3959
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.0214 0.0643
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0032 0.0168 0.0837
Brugia malayi jmjC domain containing protein 0.012 0.1205 0.2203
Schistosoma mansoni thyroid hormone receptor 0.0145 0.1503 0.5139
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0022 0.005 0.0043
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0203 0.0731
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0308 0.0858
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0034 0.019 0.0631
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0032 0.0168 0.0468
Echinococcus granulosus regulator of G protein signaling 3 0.002 0.0033 0.005
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0033 0.0008
Loa Loa (eye worm) pyruvate kinase 0.0036 0.0211 0.0343
Trypanosoma cruzi cytochrome P450, putative 0.0021 0.0035 0.002
Mycobacterium tuberculosis Conserved hypothetical protein 0.017 0.1794 0.7374
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0165 0.1739 0.4798
Loa Loa (eye worm) cytochrome P450 family protein 0.0021 0.0035 0.0013
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.0034 0.019 0.053
Schistosoma mansoni hypothetical protein 0.01 0.0975 0.3325
Loa Loa (eye worm) hypothetical protein 0.002 0.0033 0.0009
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.007 0.0613 0.2022
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0297 0.0494
Echinococcus multilocularis pyruvate kinase 0.0036 0.0211 0.0205
Echinococcus multilocularis carbonic anhydrase 0.0165 0.1739 0.1733
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0161 0.0244
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0028 0.0119 0.0583
Onchocerca volvulus 0.0035 0.0203 0.0301
Brugia malayi Phosphoglycerate kinase 0.0182 0.1934 0.3569
Echinococcus granulosus regulator of G protein signaling 7 0.002 0.0033 0.005
Schistosoma mansoni jumonji/arid domain-containing protein 0.012 0.1205 0.4113
Echinococcus multilocularis caspase 2 0.0083 0.0769 0.0762
Brugia malayi hypothetical protein 0.0034 0.019 0.0304
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0203 0.0321
Loa Loa (eye worm) TK/EGFR protein kinase 0.0159 0.1669 0.3073
Echinococcus granulosus carbonic anhydrase 0.0165 0.1739 0.3383
Echinococcus multilocularis expressed protein 0.0399 0.449 0.4487
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.0214 0.0341
Echinococcus granulosus caspase 0.0114 0.1129 0.2193
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0203 0.0674
Echinococcus multilocularis JmjC domain containing protein 4 0.0032 0.0168 0.0161
Mycobacterium tuberculosis Conserved protein 0.0035 0.0203 0.0731
Schistosoma mansoni pyruvate kinase 0.0036 0.0211 0.0702
Brugia malayi hypothetical protein 0.0024 0.008 0.0097
Schistosoma mansoni tyrosine kinase 0.0085 0.0789 0.2688
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0032 0.0168 0.0554
Schistosoma mansoni ap endonuclease 0.002 0.0028 0.0073
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0153 0.1591 0.4383
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0044 0.0308 0.0514
Schistosoma mansoni flap endonuclease-1 0.0025 0.0088 0.0277
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0067 0.0578 0.1542
Loa Loa (eye worm) hypothetical protein 0.0035 0.0203 0.0328
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0165 0.1739 0.5947
Echinococcus multilocularis regulator of G protein signaling 7 0.002 0.0033 0.0026
Trypanosoma cruzi pyruvate kinase 2, putative 0.0036 0.0211 0.0514
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0021 0.0035 0.0025
Trichomonas vaginalis phosphofructokinase, putative 0.0116 0.116 0.2074
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.0362 0.0625
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.0214 0.054
Loa Loa (eye worm) 6-phosphofructokinase 0.0116 0.116 0.2119
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.002 0.0033 0.0026
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0203 0.0731
Mycobacterium leprae Probable pyruvate kinase PykA 0.0036 0.0211 0.014
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0203 0.0731
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0043 0.0297 0.0494
Loa Loa (eye worm) beta-lactamase 0.0035 0.0203 0.0328
Schistosoma mansoni rab6-interacting 0.0021 0.0039 0.0112
Leishmania major phosphoglycerate kinase B, cytosolic 0.0182 0.1934 0.5345
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0214 0.0521
Loa Loa (eye worm) hypothetical protein 0.0035 0.0203 0.0328
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0312 0.3471 0.6311
Echinococcus multilocularis carbonic anhydrase 0.0165 0.1739 0.1733
Loa Loa (eye worm) hypothetical protein 0.0035 0.0203 0.0328
Toxoplasma gondii phosphofructokinase PFKII 0.0031 0.0161 0.08
Echinococcus granulosus axis inhibition protein axin 0.002 0.0033 0.005
Trypanosoma cruzi metacaspase, putative 0.0043 0.0297 0.0755
Loa Loa (eye worm) hypothetical protein 0.0473 0.5367 1
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.002 0.0033 0.0009
Loa Loa (eye worm) pyruvate kinase 0.0036 0.0211 0.0343
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0214 0.0207
Brugia malayi Protein kinase domain containing protein 0.0051 0.0391 0.068
Toxoplasma gondii 6-phosphofructokinase 0.0031 0.0161 0.08
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0031 0.0161 0.0445
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0297 0.0494
Loa Loa (eye worm) jmjC domain-containing protein 0.0032 0.0168 0.0262
Echinococcus granulosus regulator of G protein signaling 3 0.002 0.0033 0.005
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0031 0.0161 0.0244
Echinococcus granulosus caspase 3 0.0071 0.0623 0.1204
Trypanosoma brucei Aminopeptidase M1, putative 0.0034 0.019 0.053
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0315 0.1057
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.007 0.0613 0.1183
Loa Loa (eye worm) hypothetical protein 0.0025 0.0084 0.0105
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0297 0.0494
Trypanosoma cruzi metacaspase 5, putative 0.0043 0.0297 0.0755
Brugia malayi hypothetical protein 0.0253 0.2768 0.5132
Schistosoma mansoni regulator of G protein signaling 0.002 0.0033 0.0088
Schistosoma mansoni lipoxygenase 0.0126 0.1276 0.4359
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.007 0.0613 0.2441
Loa Loa (eye worm) hypothetical protein 0.0035 0.0203 0.0328
Mycobacterium leprae PROBABLE D-AMINO ACID OXIDASE AAO 0.0179 0.19 0.5804
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.002 0.0033 0.0009
Trichomonas vaginalis esterase, putative 0.0035 0.0203 0.0321
Schistosoma mansoni hypothetical protein 0.0165 0.1739 0.5947
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0297 0.0494
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0214 0.0341
Onchocerca volvulus 0.0035 0.0203 0.0301
Trichomonas vaginalis phosphofructokinase, putative 0.0116 0.116 0.2074
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.007 0.0613 0.2022
Echinococcus multilocularis muscleblind protein 0.0145 0.15 0.1494
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0203 0.0197
Echinococcus multilocularis Protein lozenge 0.0059 0.0491 0.0484
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0033 0.0088
Treponema pallidum methylgalactoside ABC transporter, periplasmic galactose-binding protein (mglB-2) 0.0285 0.315 0.9069
Trypanosoma cruzi pyruvate kinase 2, putative 0.0036 0.0211 0.0514
Brugia malayi Muscleblind-like protein 0.0145 0.15 0.2757
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0312 0.3471 0.6311
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.007 0.0613 0.1639
Onchocerca volvulus 0.0034 0.019 0.0277
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0203 0.0321
Entamoeba histolytica hypothetical protein 0.002 0.0033 0.0013
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0034 0.019 0.0456
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0043 0.0297 0.0494
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0182 0.1934 0.5345
Mycobacterium leprae Possible D-ribose-binding protein 0.0285 0.315 1
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0182 0.1934 0.3494
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0165 0.1739 0.3204
Brugia malayi beta-lactamase 0.0035 0.0203 0.0328
Loa Loa (eye worm) hypothetical protein 0.0036 0.0211 0.0343
Echinococcus granulosus aminopeptidase N 0.0034 0.019 0.0359
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0028 0.0078
Loa Loa (eye worm) hypothetical protein 0.0033 0.0181 0.0287
Onchocerca volvulus Pyruvate kinase homolog 0.0036 0.0211 0.0315
Chlamydia trachomatis pyruvate kinase 0.0036 0.0211 0.0284
Echinococcus multilocularis insulin receptor 0.0051 0.0391 0.0385
Echinococcus granulosus lysine specific demethylase 6a 0.0032 0.0168 0.0315
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.0556 0.1825
Loa Loa (eye worm) hypothetical protein 0.002 0.0033 0.0009
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0153 0.1589 0.5399
Schistosoma mansoni phosphoglycerate kinase 0.0182 0.1934 0.6618
Echinococcus granulosus caspase 2 0.0083 0.0769 0.1488
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0028 0.0041
Treponema pallidum fructose-bisphosphate aldolase 0.0312 0.3471 1
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0034 0.019 0.0184
Trypanosoma brucei metacaspase MCA2 0.0043 0.0297 0.0828
Echinococcus granulosus dna polymerase kappa 0.0044 0.0308 0.0589
Loa Loa (eye worm) glutaminase 0.0265 0.2919 0.5414
Brugia malayi PXA domain containing protein 0.002 0.0033 0.0009
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0086 0.08 0.155
Brugia malayi Furin-like cysteine rich region family protein 0.0159 0.1669 0.3073
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0043 0.0297 0.0494
Loa Loa (eye worm) hypothetical protein 0.0473 0.5367 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.005 0.0041
Echinococcus granulosus flap endonuclease 1 0.0028 0.0119 0.0219
Loa Loa (eye worm) TK/INSR protein kinase 0.0051 0.0391 0.068
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0126 0.1276 0.127
Toxoplasma gondii ABC1 family protein 0.0035 0.0203 0.1019
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0312 0.3471 1
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.002 0.0033 0.0088
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0034 0.019 0.0359
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0067 0.0578 0.1542
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0065 0.0556 0.0549
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0153 0.1591 0.4383
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0323 0.3593 1
Schistosoma mansoni glutaminase 0.0265 0.2919 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.008 0.0097
Trypanosoma cruzi DNA polymerase kappa, putative 0.0044 0.0308 0.0786
Mycobacterium ulcerans aminopeptidase N PepN 0.0034 0.019 0.0562
Trypanosoma brucei metacaspase 0.0043 0.0297 0.0828
Brugia malayi beta-lactamase family protein 0.0035 0.0203 0.0328
Mycobacterium ulcerans 6-phosphofructokinase 0.0116 0.116 0.3915
Brugia malayi 6-phosphofructokinase 0.0116 0.116 0.2119
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0161 0.0244
Leishmania major hypothetical protein, conserved 0.0035 0.0203 0.0491
Schistosoma mansoni tyrosine kinase 0.0051 0.0391 0.132
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0165 0.1739 0.3204
Echinococcus multilocularis beta adrenergic receptor kinase 0.002 0.0033 0.0026
Echinococcus granulosus caspase 8 0.0043 0.0297 0.0568
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0043 0.0297 0.0494
Brugia malayi Regulator of G protein signaling domain containing protein 0.002 0.0033 0.0009
Schistosoma mansoni phd/f-box containing protein 0.0032 0.0168 0.0554
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0033 0.0088
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0165 0.1739 0.4798
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0034 0.019 0.0184
Trypanosoma brucei phosphoglycerate kinase 0.0182 0.1934 0.5382
Schistosoma mansoni tyrosine kinase 0.0086 0.08 0.2724

Activities

Activity type Activity value Assay description Source Reference
-Log IC25 (functional) = 7.5 Negative inotropy measured as the concentration required to depress contraction in the isolated Langendorff-perfused guinea pig heart by 25% ChEMBL. 2943898
-Log IC50 (functional) = 7.8 In vitro calcium antagonist activity was assessed against calcium induced constriction of potassium-depolarized rat aorta ChEMBL. 2943898

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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