Detailed information for compound 693435

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 444.526 | Formula: C26H28N4O3
  • H donors: 2 H acceptors: 3 LogP: 3.17 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOc1ccccc1NC(=O)C(=O)NCC(N1CCc2c(C1)cccc2)c1cccnc1
  • InChi: 1S/C26H28N4O3/c1-2-33-24-12-6-5-11-22(24)29-26(32)25(31)28-17-23(20-10-7-14-27-16-20)30-15-13-19-8-3-4-9-21(19)18-30/h3-12,14,16,23H,2,13,15,17-18H2,1H3,(H,28,31)(H,29,32)
  • InChiKey: QXYPYEQGYIGHKG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0116 0.0116
Plasmodium vivax hypothetical protein, conserved 0.0036 0.064 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.064 0.064
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0277 0.0553
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.0277 0.0729
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0277 0.0729
Loa Loa (eye worm) hypothetical protein 0.0012 0.0116 0.0116
Schistosoma mansoni serine/threonine protein kinase 0.0186 0.3795 1
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0056 0.1054 0.0675
Schistosoma mansoni hypothetical protein 0.0048 0.0885 0.2331
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.002 0.0286 0.0286
Echinococcus multilocularis survival motor neuron protein 1 0.0236 0.4843 0.6943
Schistosoma mansoni hypothetical protein 0.0034 0.0582 0.1533
Loa Loa (eye worm) RGS-3 protein 0.0019 0.0277 0.0277
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0012 0.0116 0.0116
Mycobacterium tuberculosis Conserved hypothetical protein 0.0173 0.3509 0.692
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0277 0.0396
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.064 0.0917
Echinococcus granulosus ecdysone induced protein 78C 0.0012 0.0116 0.0166
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0277 0.0396
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0019 0.0277 0.0553
Brugia malayi hypothetical protein 0.0236 0.4843 0.4843
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.02 0.0286
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0012 0.0116 0.0116
Brugia malayi nuclear receptor NHR-88 0.0012 0.0116 0.0116
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.02 0.02
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0277 0.0553
Echinococcus granulosus Regulator of G protein signaling 20 0.0019 0.0277 0.0396
Schistosoma mansoni hypothetical protein 0.0016 0.02 0.0526
Schistosoma mansoni z-protein (S1r protein) 0.0019 0.0277 0.0729
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0082 0.0082
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0012 0.0116 0.0166
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0012 0.0116 0.0166
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0116 0.0116
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0084 0.0121
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.091 0.2399
Toxoplasma gondii hypothetical protein 0.0053 0.0984 0.8588
Schistosoma mansoni axis inhibition protein axin 0.0019 0.0277 0.0729
Brugia malayi nuclear hormone receptor 0.0012 0.0116 0.0116
Onchocerca volvulus 0.0036 0.064 0.053
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.002 0.0286 0.0286
Schistosoma mansoni cpg binding protein 0.0029 0.0488 0.1285
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0507 0.1336
Brugia malayi regulator of G-protein signaling egl-10 0.0019 0.0277 0.0277
Echinococcus granulosus tumor protein p63 0.0337 0.6976 1
Loa Loa (eye worm) histone methyltransferase 0.001 0.0084 0.0084
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0145 0.2925 0.4193
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0012 0.0116 0.0116
Echinococcus multilocularis GPCR, family 2 0.0016 0.02 0.0286
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0046 0.0842 0.0329
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0155 0.3139 0.4072
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.064 0.0917
Loa Loa (eye worm) hypothetical protein 0.0034 0.0582 0.0582
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0116 0.0116
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0012 0.0116 0.0116
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0012 0.0116 0.0116
Brugia malayi regulator of G-protein signaling rgs-7 0.0019 0.0277 0.0277
Entamoeba histolytica hypothetical protein 0.0019 0.0277 0.5
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0012 0.0116 0.0305
Onchocerca volvulus 0.0048 0.0885 0.0778
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0012 0.0116 0.0166
Brugia malayi Pre-SET motif family protein 0.0207 0.4229 0.4229
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.0277 0.0729
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0507 0.0727
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0116 0.0116
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0019 0.0277 0.0277
Loa Loa (eye worm) hypothetical protein 0.0012 0.0116 0.0116
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0155 0.3139 0.4072
Loa Loa (eye worm) hypothetical protein 0.0012 0.0116 0.0116
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0277 0.0553
Echinococcus multilocularis G protein coupled receptor kinase 1 0.0167 0.3389 0.4858
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0012 0.0116 0.0116
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0063 0.1203 0.3169
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0277 0.0396
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0277 0.0277
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0277 0.0396
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0008 0.0047 0.0067
Loa Loa (eye worm) beta-lactamase 0.0036 0.064 0.064
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0286 0.0754
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0277 0.0396
Trichomonas vaginalis esterase, putative 0.0036 0.064 0.1306
Brugia malayi PXA domain containing protein 0.0019 0.0277 0.0277
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0012 0.0116 0.0116
Loa Loa (eye worm) hypothetical protein 0.0036 0.064 0.064
Schistosoma mansoni hypothetical protein 0.0016 0.02 0.0526
Echinococcus multilocularis cpg binding protein 0.0031 0.0523 0.075
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0911 0.0911
Echinococcus multilocularis beta adrenergic receptor kinase 0.0186 0.3795 0.544
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0488 0.0488
Onchocerca volvulus 0.003 0.0507 0.0396
Echinococcus granulosus G protein coupled receptor kinase 1 0.0167 0.3389 0.4858
Loa Loa (eye worm) hypothetical protein 0.0049 0.091 0.091
Loa Loa (eye worm) runx1 0.006 0.1141 0.1141
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0277 0.0396
Schistosoma mansoni hypothetical protein 0.0016 0.02 0.0526
Echinococcus multilocularis tumor protein p63 0.0337 0.6976 1
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0019 0.0277 0.0396
Loa Loa (eye worm) hypothetical protein 0.0481 1 1
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0008 0.0047 0.0067
Mycobacterium ulcerans hypothetical protein 0.0173 0.3509 1
Brugia malayi steroid hormone receptor 0.0012 0.0116 0.0116
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0012 0.0116 0.0166
Brugia malayi ecdysteroid receptor 0.0012 0.0116 0.0116
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0277 0.0396
Entamoeba histolytica hypothetical protein 0.0019 0.0277 0.5
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0012 0.0116 0.0166
Trichomonas vaginalis set domain proteins, putative 0.0235 0.4829 1
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0012 0.0116 0.0116
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0507 0.0727
Brugia malayi beta-lactamase family protein 0.0036 0.064 0.064
Onchocerca volvulus 0.0049 0.091 0.0804
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.064 0.1686
Loa Loa (eye worm) hypothetical protein 0.0012 0.0116 0.0116
Brugia malayi A-kinase anchor protein 10, precursor 0.0019 0.0277 0.0277
Schistosoma mansoni cpg binding protein 0.0031 0.0523 0.1378
Leishmania major mitochondrial DNA polymerase beta 0.0328 0.6777 1
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0145 0.2925 0.4193
Schistosoma mansoni hypothetical protein 0.0145 0.2925 0.7707
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0116 0.0166
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0019 0.0277 0.0729
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0233 0.4785 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.064 0.064
Loa Loa (eye worm) hypothetical protein 0.0019 0.0277 0.0277
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0084 0.0121
Schistosoma mansoni axis inhibition protein axin 0.0019 0.0277 0.0729
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0277 0.0553
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0012 0.0116 0.0116
Onchocerca volvulus 0.0036 0.064 0.053
Onchocerca volvulus 0.0029 0.0488 0.0376
Loa Loa (eye worm) hypothetical protein 0.0019 0.0277 0.0277
Schistosoma mansoni steroid hormone receptor ad4bp 0.0012 0.0116 0.0305
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0012 0.0116 0.0166
Loa Loa (eye worm) hypothetical protein 0.0036 0.064 0.064
Schistosoma mansoni retinoic acid receptor RXR 0.0012 0.0116 0.0305
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0471 0.0675
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.02 0.0286
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0116 0.0116
Mycobacterium leprae conserved hypothetical protein 0.0036 0.064 0.5
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0186 0.3795 0.3795
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0019 0.0277 0.0396
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0582 0.0582
Loa Loa (eye worm) hypothetical protein 0.0236 0.4843 0.4843
Brugia malayi Latrophilin receptor protein 2 0.0016 0.02 0.02
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0911 0.0911
Echinococcus granulosus mixed lineage leukemia protein mll 0.0008 0.0047 0.0067
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0328 0.6777 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0507 0.1336
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.064 0.1306
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0046 0.0842 0.0329
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0116 0.0166
Brugia malayi Pre-SET motif family protein 0.003 0.0507 0.0507
Schistosoma mansoni thyroid hormone receptor 0.0157 0.317 0.8353
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0277 0.0729
Loa Loa (eye worm) hypothetical protein 0.0049 0.0911 0.0911
Brugia malayi PXA domain containing protein 0.0019 0.0277 0.0277
Toxoplasma gondii ABC1 family protein 0.0036 0.064 0.2386
Brugia malayi beta-lactamase 0.0036 0.064 0.064
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0012 0.0116 0.0305
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0116 0.0166
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0207 0.4229 0.4229
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0116 0.0116
Echinococcus granulosus FTZ F1 alpha 0.0012 0.0116 0.0166
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0008 0.0047 0.0123
Schistosoma mansoni nuclear hormone receptor 0.0012 0.0116 0.0305
Echinococcus multilocularis regulator of G protein signaling 0.0019 0.0277 0.0396
Loa Loa (eye worm) hypothetical protein 0.0036 0.064 0.064
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0012 0.0116 0.0166
Echinococcus granulosus survival motor neuron protein 1 0.0236 0.4843 0.6943
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.02 0.02
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0277 0.0396
Echinococcus multilocularis ecdysone induced protein 78C 0.0012 0.0116 0.0166
Schistosoma mansoni RAR-like nuclear receptor 0.0012 0.0116 0.0305
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0046 0.0842 0.0329
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0012 0.0116 0.0116
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0277 0.0729
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0507 0.0727
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0277 0.0396
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0328 0.6777 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0116 0.0166
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.02 0.0286
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0328 0.6777 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0277 0.0277
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.064 0.064
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0277 0.0277
Loa Loa (eye worm) hypothetical protein 0.0036 0.064 0.064
Loa Loa (eye worm) hypothetical protein 0.0012 0.0116 0.0116
Loa Loa (eye worm) hypothetical protein 0.0019 0.0277 0.0277
Schistosoma mansoni serine/threonine protein kinase 0.0186 0.3795 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0012 0.0116 0.0166
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0277 0.0553
Schistosoma mansoni coup transcription factor 0.0012 0.0116 0.0305
Echinococcus granulosus GPCR family 2 0.0016 0.02 0.0286
Loa Loa (eye worm) hypothetical protein 0.0019 0.0277 0.0277
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0277 0.0396
Brugia malayi photoreceptor-specific nuclear receptor 0.0012 0.0116 0.0116
Toxoplasma gondii histone lysine methyltransferase SET1 0.0057 0.1063 1
Echinococcus multilocularis Regulator of G protein signaling 20 0.0019 0.0277 0.0396
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.064 0.1306
Brugia malayi CXXC zinc finger family protein 0.0029 0.0488 0.0488
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0885 0.0885
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0155 0.3139 0.4072
Onchocerca volvulus 0.0235 0.4829 0.4769
Schistosoma mansoni cpg binding protein 0.0031 0.0523 0.1378
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0277 0.0396
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0277 0.0729
Loa Loa (eye worm) hypothetical protein 0.0012 0.0116 0.0116
Loa Loa (eye worm) steroid hormone receptor 0.0012 0.0116 0.0116
Echinococcus granulosus cpg binding protein 0.0031 0.0523 0.075
Echinococcus multilocularis FTZ F1 alpha 0.0012 0.0116 0.0166
Echinococcus multilocularis Protein lozenge 0.006 0.1141 0.1636
Schistosoma mansoni survival motor neuron protein 0.0048 0.0885 0.2331
Schistosoma mansoni lozenge 0.006 0.1141 0.3007
Brugia malayi Steroid receptor seven-up type 2 0.0012 0.0116 0.0116
Brugia malayi beta-lactamase family protein 0.0036 0.064 0.064
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0507 0.1336
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0911 0.0911
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.064 0.1686
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0012 0.0116 0.0166
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.064 0.1306
Loa Loa (eye worm) hypothetical protein 0.003 0.0507 0.0507
Entamoeba histolytica hypothetical protein 0.0019 0.0277 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0277 0.0553
Loa Loa (eye worm) hypothetical protein 0.0012 0.0116 0.0116
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0507 0.1336
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0012 0.0116 0.0305
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.064 0.1306
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0012 0.0116 0.0116
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0012 0.0116 0.0305
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.064 0.1306
Loa Loa (eye worm) hypothetical protein 0.0012 0.0116 0.0116
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.02 0.0286
Schistosoma mansoni thyroid hormone receptor 0.0157 0.317 0.8353
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0012 0.0116 0.0116
Echinococcus multilocularis thyroid hormone receptor alpha 0.0157 0.317 0.4544
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0012 0.0116 0.0116
Mycobacterium leprae Probable lipase LipE 0.0036 0.064 0.5
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0046 0.0842 0.0329
Echinococcus granulosus beta-adrenergic receptor kinase 0.0186 0.3795 0.544
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0277 0.0729
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0277 0.0396
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0116 0.0116
Loa Loa (eye worm) PXA domain-containing protein 0.0019 0.0277 0.0277
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0012 0.0116 0.0116
Echinococcus granulosus expressed protein 0.0019 0.0277 0.0396
Brugia malayi hypothetical protein 0.0019 0.0277 0.0277
Brugia malayi hypothetical protein 0.0019 0.0277 0.0277
Loa Loa (eye worm) hypothetical protein 0.0019 0.0277 0.0277
Echinococcus multilocularis expressed protein 0.0019 0.0277 0.0396
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0008 0.0047 0.0067
Loa Loa (eye worm) hypothetical protein 0.0481 1 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0012 0.0116 0.0305
Onchocerca volvulus 0.0036 0.064 0.053
Loa Loa (eye worm) hypothetical protein 0.0036 0.064 0.064
Onchocerca volvulus 0.0481 1 1
Schistosoma mansoni hypothetical protein 0.0016 0.02 0.0526
Loa Loa (eye worm) hypothetical protein 0.0016 0.02 0.02
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.0116 0.0305

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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