Detailed information for compound 702685

Basic information

Technical information
  • TDR Targets ID: 702685
  • Name: N-[4-(4-cyanophenyl)-1,3-thiazol-2-yl]-2-(4-m ethylsulfanylphenyl)acetamide
  • MW: 365.472 | Formula: C19H15N3OS2
  • H donors: 1 H acceptors: 3 LogP: 3.95 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CSc1ccc(cc1)CC(=O)Nc1scc(n1)c1ccc(cc1)C#N
  • InChi: 1S/C19H15N3OS2/c1-24-16-8-4-13(5-9-16)10-18(23)22-19-21-17(12-25-19)15-6-2-14(11-20)3-7-15/h2-9,12H,10H2,1H3,(H,21,22,23)
  • InChiKey: FXUMNAIELZCXDY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[4-(4-cyanophenyl)thiazol-2-yl]-2-(4-methylsulfanylphenyl)acetamide
  • N-[4-(4-cyanophenyl)-2-thiazolyl]-2-[4-(methylthio)phenyl]acetamide
  • N-[4-(4-cyanophenyl)thiazol-2-yl]-2-[4-(methylthio)phenyl]acetamide
  • N-[4-(4-cyanophenyl)-1,3-thiazol-2-yl]-2-(4-methylsulfanylphenyl)ethanamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni hypothetical protein 0.0018 0.0095 0.0226
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.006 0.0557 0.1326
Loa Loa (eye worm) hypothetical protein 0.0049 0.0441 0.1182
Brugia malayi Calcitonin receptor-like protein seb-1 0.0056 0.052 0.1573
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0031 0.0236 0.3582
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.0111 0.0298
Brugia malayi AF-10 protein 0.002 0.0114 0.0345
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0188 0.1964 0.4673
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0069 0.0658 0.1564
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0139 0.143 0.3983
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0038 0.0038
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0022 0.0136 0.0073
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0022 0.0142 0.5
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0285 0.3034 0.9145
Trypanosoma brucei importin beta-1 subunit, putative 0.0033 0.0258 0.4441
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.002 0.0114 0.0081
Onchocerca volvulus Fatty acid synthase homolog 0.0048 0.0423 0.652
Leishmania major GTP-binding protein, putative 0.0024 0.0163 0.1567
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0026 0.018 0.0478
Echinococcus multilocularis muscleblind protein 1 0.0151 0.1563 0.1563
Echinococcus granulosus GTP binding nuclear protein Ran 0.0024 0.0163 0.0388
Mycobacterium ulcerans glutaminase 0.0309 0.3304 0.9556
Loa Loa (eye worm) hypothetical protein 0.0026 0.0188 0.0503
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0025 0.017 0.0456
Schistosoma mansoni hypothetical protein 0.0348 0.3733 0.8883
Echinococcus granulosus intermediate filament protein 0.0026 0.0188 0.0447
Echinococcus granulosus lysine specific demethylase 6a 0.0019 0.0111 0.0265
Mycobacterium ulcerans bifunctional nicotinate-nucleotide adenylyltransferase NadD/hypothetical protein 0.0323 0.3453 1
Plasmodium vivax importin-beta 2, putative 0.0033 0.0258 0.0438
Loa Loa (eye worm) flap endonuclease-1 0.0031 0.0236 0.0631
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0021 0.0133 0.0124
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0026 0.0189 0.0504
Loa Loa (eye worm) CXXC zinc finger family protein 0.0032 0.0256 0.0687
Echinococcus multilocularis lysine specific demethylase 5A 0.0072 0.0696 0.0696
Echinococcus multilocularis cpg binding protein 0.0034 0.0277 0.0277
Brugia malayi jmjC domain containing protein 0.0196 0.2056 0.6224
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0056 0.052 0.1392
Echinococcus granulosus flap endonuclease 1 0.0031 0.0236 0.0561
Loa Loa (eye worm) hypothetical protein 0.0018 0.0095 0.0255
Echinococcus multilocularis peregrin 0.006 0.0557 0.0557
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0022 0.0142 0.0338
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.002 0.0114 0.1289
Mycobacterium ulcerans Type I modular polyketide synthase 0.0026 0.0189 0.0293
Loa Loa (eye worm) hypothetical protein 0.0013 0.0038 0.0103
Onchocerca volvulus 0.0032 0.0256 0.2224
Brugia malayi intermediate filament protein 0.0026 0.0188 0.0569
Onchocerca volvulus Alhambra homolog 0.006 0.0557 1
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.0015 0.0064 0.0139
Echinococcus granulosus PHD finger protein rhinoceros 0.006 0.0557 0.1326
Mycobacterium tuberculosis Probable thioesterase TesA 0.0022 0.0141 0.0363
Schistosoma mansoni cellular tumor antigen P53 0.0052 0.0476 0.1133
Schistosoma mansoni cpg binding protein 0.0034 0.0277 0.0659
Brugia malayi AMP-binding enzyme family protein 0.0025 0.017 0.0515
Onchocerca volvulus 0.0052 0.0476 0.7902
Schistosoma mansoni ap endonuclease 0.0022 0.0142 0.0338
Schistosoma mansoni hypothetical protein 0.006 0.0557 0.1326
Schistosoma mansoni ran 0.0024 0.0163 0.0388
Echinococcus granulosus muscleblind protein 0.0151 0.1563 0.372
Brugia malayi Bromodomain containing protein 0.006 0.0557 0.1687
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0285 0.3034 0.9145
Loa Loa (eye worm) PHD-finger family protein 0.006 0.0557 0.1493
Plasmodium vivax flap endonuclease 1, putative 0.0031 0.0236 0.0372
Brugia malayi CXXC zinc finger family protein 0.0032 0.0256 0.0776
Echinococcus multilocularis GPCR, family 2 0.0018 0.0095 0.0095
Plasmodium vivax ataxin-2 like protein, putative 0.0049 0.0441 0.0987
Brugia malayi hypothetical protein 0.0035 0.0285 0.0861
Loa Loa (eye worm) fatty acid synthase 0.0026 0.0186 0.0497
Mycobacterium ulcerans polyketide synthase 0.0028 0.0207 0.0347
Schistosoma mansoni hypothetical protein 0.0022 0.0142 0.0338
Loa Loa (eye worm) hypothetical protein 0.0012 0.0033 0.0088
Schistosoma mansoni hypothetical protein 0.002 0.0114 0.0271
Giardia lamblia Fructose-bisphosphate aldolase 0.0285 0.3034 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0134 0.036
Echinococcus multilocularis PHD finger protein rhinoceros 0.006 0.0557 0.0557
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0056 0.052 0.1573
Trichomonas vaginalis flap endonuclease-1, putative 0.0031 0.0236 0.0296
Schistosoma mansoni hypothetical protein 0.0035 0.0285 0.0677
Trichomonas vaginalis importin beta-1, putative 0.0026 0.019 0.0151
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0285 0.0677
Echinococcus granulosus phd:f box containing protein 0.0019 0.0111 0.0265
Schistosoma mansoni hypothetical protein 0.0018 0.0095 0.0226
Loa Loa (eye worm) hypothetical protein 0.0012 0.0033 0.0088
Entamoeba histolytica Ran family GTPase 0.0024 0.0163 0.0072
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.002 0.0114 0.0081
Toxoplasma gondii type I fatty acid synthase, putative 0.0019 0.0106 0.1131
Schistosoma mansoni protein phosphatase 2C 0.0019 0.0111 0.0265
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0022 0.0136 0.035
Brugia malayi PHD-finger family protein 0.0021 0.0134 0.0407
Echinococcus multilocularis lamin dm0 0.0026 0.0188 0.0188
Echinococcus granulosus lamin dm0 0.0026 0.0188 0.0447
Plasmodium vivax hypothetical protein, conserved 0.0022 0.0136 0.0073
Mycobacterium tuberculosis Probable nicotinate-nucleotide adenylyltransferase NadD (deamido-NAD(+) pyrophosphorylase) (deamido-NAD(+) diphosphorylase) (nic 0.0323 0.3453 1
Mycobacterium leprae Probable polyketide synthase Pks1 0.0028 0.0207 0.0347
Schistosoma mansoni hypothetical protein 0.0018 0.0095 0.0226
Schistosoma mansoni hypothetical protein 0.0018 0.0095 0.0226
Schistosoma mansoni importin beta-1 0.0033 0.0258 0.0614
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0022 0.0142 0.0092
Plasmodium falciparum ataxin-2 like protein, putative 0.0049 0.0441 0.0987
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0022 0.0142 0.0366
Echinococcus multilocularis snurportin 1 0.0348 0.3733 0.3733
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0026 0.0189 0.0573
Echinococcus multilocularis jumonji domain containing 1A 0.0019 0.0111 0.0111
Loa Loa (eye worm) histone methyltransferase 0.001 0.0009 0.0025
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0348 0.3733 1
Schistosoma mansoni ap endonuclease 0.0022 0.0142 0.0338
Echinococcus granulosus geminin 0.0391 0.4203 1
Brugia malayi RNA, U transporter 1 0.0093 0.092 0.2785
Echinococcus multilocularis lysine specific demethylase 6a 0.0019 0.0111 0.0111
Echinococcus multilocularis geminin 0.0391 0.4203 0.4203
Schistosoma mansoni hypothetical protein 0.0391 0.4203 1
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0196 0.2056 0.2056
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0285 0.3034 0.9145
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0188 0.1964 0.1964
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0028 0.0207 0.0347
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0285 0.3034 1
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0022 0.0142 0.0142
Echinococcus multilocularis tumor protein p63 0.0358 0.3845 0.3845
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0196 0.2056 0.4893
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0188 0.1964 0.5944
Brugia malayi PHD-finger family protein 0.006 0.0557 0.1687
Trypanosoma brucei PAB1-binding protein , putative 0.0049 0.0441 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.019 0.0151
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0285 0.3034 1
Echinococcus granulosus lamin 0.0026 0.0188 0.0447
Loa Loa (eye worm) acyl carrier protein 0.0012 0.0032 0.0087
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0024 0.0163 0.1567
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0285 0.3034 0.9145
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.0021 0.0133 0.0124
Toxoplasma gondii LsmAD domain-containing protein 0.0049 0.0441 0.7454
Schistosoma mansoni jumonji domain containing protein 0.0019 0.0111 0.0265
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0022 0.0142 0.0381
Trichomonas vaginalis ran, putative 0.0024 0.0163 0.0066
Loa Loa (eye worm) hypothetical protein 0.0103 0.1028 0.2754
Echinococcus multilocularis jumonji domain containing protein 0.0083 0.0816 0.0816
Loa Loa (eye worm) MH2 domain-containing protein 0.0135 0.1386 0.3712
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0285 0.0677
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0022 0.0142 0.0933
Toxoplasma gondii HEAT repeat-containing protein 0.0033 0.0258 0.3999
Loa Loa (eye worm) hypothetical protein 0.0019 0.0111 0.0298
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0022 0.0142 0.0933
Echinococcus granulosus tumor protein p63 0.0358 0.3845 0.9148
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0188 0.1964 0.1964
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0018 0.0095 0.0095
Brugia malayi jmjC domain containing protein 0.0074 0.0717 0.2169
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0024 0.0163 0.0437
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0188 0.1964 0.4673
Brugia malayi hypothetical protein 0.0032 0.0249 0.0754
Loa Loa (eye worm) glutaminase 0.0309 0.3304 0.885
Echinococcus granulosus JmjC domain containing protein 4 0.0019 0.0111 0.0265
Brugia malayi MH2 domain containing protein 0.0135 0.1386 0.4195
Brugia malayi jmjC domain containing protein 0.0019 0.0111 0.0337
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0028 0.0207 0.0347
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0188 0.1964 0.4673
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0024 0.0163 0.0155
Plasmodium falciparum flap endonuclease 1 0.0031 0.0236 0.0372
Loa Loa (eye worm) glutaminase 2 0.0309 0.3304 0.885
Schistosoma mansoni jumonji/arid domain-containing protein 0.0074 0.0717 0.1705
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0028 0.0203 0.0483
Schistosoma mansoni cpg binding protein 0.0032 0.0256 0.061
Echinococcus granulosus peregrin 0.006 0.0557 0.1326
Leishmania major importin beta-1 subunit, putative 0.0026 0.019 0.2382
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0188 0.0503
Echinococcus multilocularis muscleblind protein 0.0151 0.1563 0.1563
Echinococcus multilocularis musashi 0.0026 0.0188 0.0188
Brugia malayi Flap endonuclease-1 0.0031 0.0236 0.0714
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0024 0.0163 0.0072
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0024 0.0163 0.1567
Loa Loa (eye worm) hypothetical protein 0.006 0.0557 0.1493
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0031 0.0236 0.3771
Leishmania major hypothetical protein, conserved 0.0049 0.0441 1
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0022 0.0142 0.0142
Brugia malayi hypothetical protein 0.0049 0.0441 0.1336
Loa Loa (eye worm) hypothetical protein 0.0019 0.0111 0.0298
Onchocerca volvulus 0.0046 0.0405 0.6054
Mycobacterium ulcerans Type I modular polyketide synthase 0.0026 0.0189 0.0293
Loa Loa (eye worm) hypothetical protein 0.0015 0.0062 0.0165
Entamoeba histolytica hypothetical protein 0.0026 0.019 0.0165
Treponema pallidum fructose-bisphosphate aldolase 0.0285 0.3034 0.8733
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0039 0.0333 0.0922
Brugia malayi Muscleblind-like protein 0.0151 0.1563 0.4732
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0022 0.0142 0.0933
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0026 0.0189 0.0504
Toxoplasma gondii histone lysine methyltransferase SET1 0.0062 0.0576 1
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0139 0.143 0.4114
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0024 0.0163 0.2212
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0022 0.0142 0.0933
Toxoplasma gondii PHD-finger domain-containing protein 0.006 0.0557 0.9643
Trypanosoma cruzi PAB1-binding protein , putative 0.0049 0.0441 1
Plasmodium falciparum importin beta, putative 0.0033 0.0258 0.0438
Echinococcus multilocularis phd:f box containing protein 0.0019 0.0111 0.0111
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0026 0.0189 0.0293
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0028 0.0207 0.0556
Loa Loa (eye worm) hypothetical protein 0.0026 0.0183 0.0489
Onchocerca volvulus 0.0026 0.0188 0.0455
Trypanosoma cruzi importin beta-1 subunit, putative 0.0026 0.019 0.2382
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0018 0.0095 0.0226
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0139 0.143 0.3983
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.0111 0.0298
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0022 0.0142 0.0338
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0018 0.0095 0.0288
Loa Loa (eye worm) hypothetical protein 0.0039 0.0323 0.0866
Schistosoma mansoni lamin 0.0026 0.0188 0.0447
Loa Loa (eye worm) jmjC domain-containing protein 0.0124 0.1259 0.3372
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0021 0.0133 0.0124
Schistosoma mansoni intermediate filament proteins 0.0026 0.0188 0.0447
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0188 0.0503
Mycobacterium leprae PROBABLE NICOTINATE-NUCLEOTIDE ADENYLYLTRANSFERASE NADD (DEAMIDO-NAD(+) PYROPHOSPHORYLASE) (DEAMIDO-NAD(+) DIPHOSPHORYLASE) (NIC 0.0323 0.3453 1
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.005 0.045 0.1361
Treponema pallidum hypothetical protein 0.0323 0.3453 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0018 0.0095 0.0226
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0285 0.3034 0.9145
Trypanosoma cruzi PAB1-binding protein , putative 0.0049 0.0441 1
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0054 0.0144
Schistosoma mansoni hypothetical protein 0.0039 0.0323 0.0769
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0285 0.3034 0.9145
Toxoplasma gondii type I fatty acid synthase, putative 0.0028 0.0207 0.3049
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0188 0.1964 0.4673
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0026 0.0189 0.0504
Schistosoma mansoni cpg binding protein 0.0034 0.0277 0.0659
Plasmodium falciparum nicotinamide/nicotinic acid mononucleotide adenylyltransferase 0.0323 0.3453 1
Mycobacterium ulcerans Type I modular polyketide synthase 0.0026 0.0189 0.0293
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0018 0.0095 0.0095
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0039 0.0333 0.0922
Brugia malayi jmjC domain containing protein 0.0019 0.0111 0.0337
Giardia lamblia Flap structure-specific endonuclease 0.0031 0.0236 0.0324
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0028 0.0207 0.0556
Echinococcus granulosus GPCR family 2 0.0018 0.0095 0.0226
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0285 0.0285
Loa Loa (eye worm) hypothetical protein 0.0044 0.0387 0.1037
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0188 0.1964 0.5261
Echinococcus granulosus importin subunit beta 1 0.0033 0.0258 0.0614
Plasmodium vivax nicotinate-nucleotide adenylyltransferase, putative 0.0323 0.3453 1
Toxoplasma gondii PHD-finger domain-containing protein 0.002 0.0114 0.1289
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0022 0.0142 0.0092
Echinococcus multilocularis flap endonuclease 1 0.0031 0.0236 0.0236
Mycobacterium ulcerans polyketide synthase Pks13 0.0039 0.0333 0.0721
Onchocerca volvulus 0.0026 0.0188 0.0455
Schistosoma mansoni glutaminase 0.0309 0.3304 0.7861
Brugia malayi Importin beta-1 subunit 0.0033 0.0258 0.078
Echinococcus multilocularis lamin 0.0026 0.0188 0.0188
Echinococcus granulosus snurportin 1 0.0348 0.3733 0.8883
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0022 0.0141 0.0149
Loa Loa (eye worm) hypothetical protein 0.0151 0.1563 0.4188
Trypanosoma brucei importin beta-1 subunit, putative 0.0033 0.0258 0.4441
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0009 0.0022
Brugia malayi jmjC domain containing protein 0.0019 0.0111 0.0337
Trichomonas vaginalis glutaminase, putative 0.0309 0.3304 1
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0026 0.018 0.0478
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0024 0.0163 0.0155
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0026 0.0189 0.0293
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0019 0.0111 0.1238
Loa Loa (eye worm) hypothetical protein 0.0052 0.0476 0.1276
Loa Loa (eye worm) hypothetical protein 0.0151 0.1563 0.4188
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0024 0.0163 0.1567
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0028 0.0207 0.0556
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0028 0.0207 0.0347
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0285 0.3034 0.9145
Schistosoma mansoni lamin 0.0026 0.0188 0.0447
Brugia malayi jmjC domain containing protein 0.0019 0.0111 0.0337
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0024 0.0163 0.0163
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0019 0.0111 0.1238
Echinococcus multilocularis JmjC domain containing protein 4 0.0019 0.0111 0.0111
Entamoeba histolytica hypothetical protein 0.0035 0.0285 0.0493
Entamoeba histolytica Flap nuclease, putative 0.0031 0.0236 0.0324
Entamoeba histolytica hypothetical protein 0.0035 0.0285 0.0493
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0019 0.0111 0.0265
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0025 0.017 0.0448
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0028 0.0207 0.0347
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0017 0.0087 0.0785
Loa Loa (eye worm) hypothetical protein 0.0056 0.052 0.1392
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0021 0.0132 0.0132
Loa Loa (eye worm) transcription factor SMAD2 0.0135 0.1386 0.3712
Schistosoma mansoni flap endonuclease-1 0.0028 0.0203 0.0484
Giardia lamblia PHD finger protein 15 0.006 0.0557 0.1437
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.019 0.0151
Plasmodium falciparum ataxin-2 like protein, putative 0.0049 0.0441 0.0987
Echinococcus granulosus jumonji domain containing protein 0.0083 0.0816 0.194
Loa Loa (eye worm) latrophilin receptor protein 2 0.0018 0.0095 0.0255
Plasmodium vivax hypothetical protein, conserved 0.006 0.0557 0.1335
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0188 0.0569
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0009 0.0009
Brugia malayi Latrophilin receptor protein 2 0.0018 0.0095 0.0288
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0188 0.1964 0.4673
Mycobacterium leprae Polyketide synthase Pks13 0.0039 0.0333 0.0721
Plasmodium falciparum phd finger protein, putative 0.006 0.0557 0.1335
Brugia malayi latrophilin 2 splice variant baaae 0.0039 0.0323 0.0978
Mycobacterium ulcerans thioesterase TesA 0.0022 0.0141 0.0149
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.0111 0.0298
Entamoeba histolytica hypothetical protein 0.0035 0.0285 0.0493
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0026 0.0189 0.0293
Mycobacterium ulcerans thioesterase 0.0022 0.0141 0.0149
Loa Loa (eye worm) hypothetical protein 0.0033 0.0258 0.0691
Loa Loa (eye worm) jmjC domain-containing protein 0.0074 0.0717 0.1919
Toxoplasma gondii PHD-finger domain-containing protein 0.006 0.0557 0.9643
Toxoplasma gondii exonuclease III APE 0.0022 0.0142 0.1818
Brugia malayi exodeoxyribonuclease III family protein 0.0022 0.0142 0.043
Entamoeba histolytica hypothetical protein 0.0035 0.0285 0.0493
Brugia malayi F/Y-rich N-terminus family protein 0.0029 0.0223 0.0676
Schistosoma mansoni ran 0.0024 0.0163 0.0388
Schistosoma mansoni jumonji/arid domain-containing protein 0.0074 0.0717 0.1705
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0054 0.0162
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0031 0.0236 0.3771
Schistosoma mansoni phosphatidylserine receptor 0.0019 0.0111 0.0265
Mycobacterium ulcerans polyketide synthase 0.0026 0.0189 0.0293
Schistosoma mansoni phd/f-box containing protein 0.0019 0.0111 0.0265
Echinococcus multilocularis importin subunit beta 1 0.0033 0.0258 0.0258
Echinococcus granulosus cpg binding protein 0.0034 0.0277 0.0659
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0024 0.0163 0.0493
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0019 0.0108 0.0266
Brugia malayi glutaminase DH11.1 0.0309 0.3304 1
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0038 0.0091
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0021 0.0132 0.0313
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0031 0.0236 0.3771
Schistosoma mansoni hypothetical protein 0.0391 0.4203 1
Schistosoma mansoni jumonji domain containing protein 0.0156 0.1613 0.3838
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0285 0.3034 0.9145
Echinococcus granulosus lysine specific demethylase 5A 0.0074 0.0717 0.1705
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0022 0.0142 0.0152
Echinococcus granulosus jumonji domain containing 1A 0.0019 0.0111 0.0265

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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