Detailed information for compound 702930

Basic information

Technical information
  • TDR Targets ID: 702930
  • Name: 2-ethyl-5-[[4-(2-hydroxyethyl)piperazin-1-yl] -thiophen-2-ylmethyl]-[1,3]thiazolo[2,3-e][1, 2,4]triazol-6-ol
  • MW: 393.527 | Formula: C17H23N5O2S2
  • H donors: 2 H acceptors: 4 LogP: 2.07 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCCN1CCN(CC1)C(c1sc2n(c1O)nc(n2)CC)c1cccs1
  • InChi: 1S/C17H23N5O2S2/c1-2-13-18-17-22(19-13)16(24)15(26-17)14(12-4-3-11-25-12)21-7-5-20(6-8-21)9-10-23/h3-4,11,14,23-24H,2,5-10H2,1H3
  • InChiKey: YZICCIIVGVJFMR-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-ethyl-5-[[4-(2-hydroxyethyl)piperazin-1-yl]-(2-thienyl)methyl]thiazolo[2,3-e][1,2,4]triazol-6-ol
  • 2-ethyl-5-[[4-(2-hydroxyethyl)-1-piperazinyl]-(2-thienyl)methyl]-6-thiazolo[2,3-e][1,2,4]triazolol
  • 2-ethyl-5-[[4-(2-hydroxyethyl)piperazin-1-yl]-thiophen-2-yl-methyl]-[1,3]thiazolo[2,3-e][1,2,4]triazol-6-ol

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Probable lipase LipE 0.0063 0.0949 0.1229
Schistosoma mansoni lamin 0.0027 0.0325 0.0478
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0032 0.042 1
Plasmodium falciparum mitogen-activated protein kinase 2 0.0178 0.2939 0.3602
Loa Loa (eye worm) hypothetical protein 0.0015 0.0126 0.0121
Mycobacterium tuberculosis Conserved protein 0.0063 0.0949 0.1229
Echinococcus granulosus solute carrier family 22 0.0015 0.0126 0.0409
Trypanosoma brucei glucose transporter, putative 0.0034 0.0448 0.178
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0042 0.0585 0.0588
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0083 0.0272
Plasmodium vivax lysine--tRNA ligase, putative 0.0025 0.0283 0.0201
Mycobacterium ulcerans lipase LipD 0.0063 0.0949 0.2657
Leishmania major glucose transporter, lmgt1 0.0034 0.0448 0.178
Schistosoma mansoni smad1 5 8 and 0.0008 0.0005 0.0007
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0369 0.0543
Schistosoma mansoni hypothetical protein 0.0164 0.2694 0.3967
Plasmodium falciparum hexose transporter 0.011 0.1759 0.2092
Loa Loa (eye worm) glutaminase 2 0.0205 0.3405 0.3402
Schistosoma mansoni protein kinase 0.0034 0.0449 0.0661
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0061 0.0908 0.1168
Echinococcus granulosus cpg binding protein 0.003 0.0383 0.1249
Brugia malayi major facilitator superfamily protein 0.0015 0.0126 0.0121
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0183 0.0074
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0038 0.0523 0.2195
Echinococcus granulosus geminin 0.0164 0.2694 0.8783
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0108 0.0103
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0183 0.0659
Onchocerca volvulus 0.0044 0.0623 0.1341
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0034 0.0449 0.1464
Toxoplasma gondii exonuclease III APE 0.0019 0.0183 0.0113
Brugia malayi Calcitonin receptor-like protein seb-1 0.0587 1 1
Schistosoma mansoni sugar transporter 0.0015 0.0126 0.0185
Schistosoma mansoni smad1 5 8 and 0.0008 0.0005 0.0007
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.042 0.0793
Echinococcus multilocularis cpg binding protein 0.003 0.0383 0.1249
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0034 0.0449 0.0444
Trichomonas vaginalis CMGC family protein kinase 0.0057 0.084 0.1927
Loa Loa (eye worm) sugar transporter 0.0015 0.0126 0.0121
Trypanosoma brucei protein kinase, putative 0.0057 0.084 0.3946
Schistosoma mansoni ap endonuclease 0.0019 0.0183 0.027
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0019 0.0187 0.0165
Onchocerca volvulus 0.0063 0.0949 0.222
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0202 0.3353 0.335
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0908 0.2536
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0038 0.0523 0.2195
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0025 0.0283 0.0867
Trichomonas vaginalis conserved hypothetical protein 0.011 0.1759 0.4405
Echinococcus granulosus GPCR family 2 0.0186 0.3067 1
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0034 0.0449 0.0444
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0186 0.3067 0.3064
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.042 0.0793
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0908 0.1337
Brugia malayi hypothetical protein 0.0015 0.0126 0.0121
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.0743 0.2422
Echinococcus multilocularis mothers against decapentaplegic 5 0.0008 0.0005 0.0016
Trypanosoma brucei glucose transporter, putative 0.0034 0.0448 0.178
Schistosoma mansoni 6-phosphofructokinase 0.012 0.1936 0.2851
Schistosoma mansoni 6-phosphofructokinase 0.012 0.1936 0.2851
Schistosoma mansoni protein kinase 0.0034 0.0449 0.0661
Echinococcus multilocularis lamin dm0 0.0027 0.0325 0.1058
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0355 0.035
Plasmodium vivax hypothetical protein, conserved 0.0019 0.0187 0.0078
Brugia malayi Pre-SET motif family protein 0.003 0.0369 0.0364
Mycobacterium tuberculosis Probable lipase LipD 0.0063 0.0949 0.1229
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0042 0.0585 0.0686
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0063 0.0949 0.0944
Loa Loa (eye worm) hypothetical protein 0.0063 0.0949 0.0944
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0034 0.0449 0.1464
Giardia lamblia Lysyl-tRNA synthetase 0.0025 0.0283 0.2197
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0008 0.0005 0.0016
Entamoeba histolytica hypothetical protein 0.0042 0.0581 0.2269
Trypanosoma cruzi metacaspase, putative 0.0019 0.0187 0.0337
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0108 0.0103
Echinococcus granulosus caspase 8 0.0019 0.0187 0.0608
Onchocerca volvulus Cell death protein 3 homolog 0.0063 0.0951 0.2226
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0019 0.0187 0.0165
Loa Loa (eye worm) hypothetical protein 0.0015 0.0126 0.0121
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0019 0.0187 0.0119
Echinococcus multilocularis General substrate transporter 0.0094 0.1492 0.4864
Onchocerca volvulus 0.0063 0.0949 0.222
Loa Loa (eye worm) hypothetical protein 0.0063 0.0949 0.0944
Brugia malayi isocitrate dehydrogenase 0.0042 0.0585 0.0581
Leishmania major glucose transporter, lmgt3 0.0034 0.0448 0.178
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0186 0.3067 1
Leishmania major glucose transporter, lmgt2 0.0034 0.0448 0.178
Plasmodium falciparum metacaspase 1 0.0019 0.0187 0.0078
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.011 0.1759 0.5736
Trypanosoma cruzi hypothetical protein, conserved 0.0063 0.0949 0.4546
Echinococcus multilocularis GPCR, family 2 0.0186 0.3067 1
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0042 0.0585 0.2538
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0057 0.084 0.3946
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0369 0.0476
Loa Loa (eye worm) hypothetical protein 0.0027 0.0322 0.0317
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0019 0.0187 0.0182
Plasmodium falciparum proline--tRNA ligase 0.0038 0.0523 0.0509
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0403 0.6825 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.0083 0.0079
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0325 0.032
Leishmania major metacaspase, putative 0.0019 0.0187 0.0337
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0019 0.0187 0.0119
Plasmodium falciparum lysine--tRNA ligase 0.0025 0.0283 0.0201
Leishmania major glucose transporter/membrane transporter D2, putative 0.0034 0.0448 0.178
Loa Loa (eye worm) 6-phosphofructokinase 0.012 0.1936 0.1932
Toxoplasma gondii facilitative glucose transporter GT1 0.011 0.1759 0.3196
Loa Loa (eye worm) hypothetical protein 0.0063 0.0949 0.0944
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0033 0.0429 0.1398
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0033 0.0429 0.0631
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0057 0.084 0.3946
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.003 0.0099
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0032 0.042 0.0793
Entamoeba histolytica hypothetical protein 0.0042 0.0581 0.2269
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0186 0.3067 1
Schistosoma mansoni transcription factor LCR-F1 0.0042 0.0581 0.0856
Trichomonas vaginalis sugar transporter, putative 0.0034 0.0448 0.0869
Schistosoma mansoni sugar transporter 0.0015 0.0126 0.0185
Trichomonas vaginalis phosphofructokinase, putative 0.012 0.1936 0.4883
Brugia malayi lysyl-tRNA synthetase 0.0025 0.0283 0.0278
Echinococcus granulosus solute carrier family 22 0.0015 0.0126 0.0409
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0448 0.0869
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0042 0.0581 0.1895
Toxoplasma gondii protein kinase, putative 0.0311 0.5238 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0316 0.0311
Echinococcus multilocularis synaptic vesicle 2 protein 0.0015 0.0126 0.0409
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0063 0.0949 0.0944
Schistosoma mansoni lysyl-tRNA synthetase 0.0025 0.0283 0.0416
Echinococcus multilocularis solute carrier family 22 0.0015 0.0126 0.0409
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0186 0.3067 1
Entamoeba histolytica phosphofructokinase, putative 0.012 0.1936 1
Trypanosoma brucei metacaspase MCA3 0.0019 0.0187 0.0337
Echinococcus multilocularis beta LACTamase domain containing family member 0.0063 0.0949 0.3093
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0033 0.0429 0.0631
Trypanosoma brucei metacaspase 5, putative 0.0019 0.0187 0.0337
Schistosoma mansoni caspase-7 (C14 family) 0.0063 0.0951 0.1401
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0025 0.0283 0.0666
Loa Loa (eye worm) hypothetical protein 0.0063 0.0949 0.0944
Loa Loa (eye worm) hypothetical protein 0.0186 0.3067 0.3064
Echinococcus granulosus calcium dependent protein kinase 0.0032 0.0404 0.1318
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.011 0.1759 0.5736
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0369 0.0543
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.011 0.1759 0.5736
Loa Loa (eye worm) latrophilin receptor protein 2 0.0186 0.3067 0.3064
Trypanosoma cruzi PAB1-binding protein , putative 0.0037 0.0489 0.201
Schistosoma mansoni lamin 0.0027 0.0325 0.0478
Trypanosoma brucei metacaspase 0.0019 0.0187 0.0337
Trichomonas vaginalis D-aminoacylase, putative 0.0063 0.0949 0.222
Trichomonas vaginalis glucose transporter, putative 0.0034 0.0448 0.0869
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0187 0.0165
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.0743 0.2422
Trypanosoma cruzi hexose transporter 0.0034 0.0448 0.178
Trypanosoma cruzi hexose transporter, putative 0.0034 0.0448 0.178
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0033 0.0429 0.1397
Echinococcus multilocularis calcium dependent protein kinase 0.0032 0.0404 0.1318
Echinococcus granulosus beta LACTamase domain containing family member 0.0063 0.0949 0.3093
Brugia malayi MAP kinase sur-1 0.0057 0.084 0.0836
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.012 0.1936 1
Plasmodium vivax 6-phosphofructokinase, putative 0.0032 0.042 0.0377
Schistosoma mansoni cpg binding protein 0.0029 0.0355 0.0523
Loa Loa (eye worm) hypothetical protein 0.0015 0.0126 0.0121
Brugia malayi CXXC zinc finger family protein 0.0029 0.0355 0.035
Loa Loa (eye worm) transcription factor SMAD2 0.0124 0.201 0.2006
Loa Loa (eye worm) hypothetical protein 0.0401 0.6791 0.679
Echinococcus multilocularis solute carrier family 22 0.0015 0.0126 0.0409
Plasmodium falciparum calcium-dependent protein kinase 5 0.0034 0.0449 0.0414
Mycobacterium ulcerans integral membrane transport protein 0.0015 0.0126 0.0197
Toxoplasma gondii isocitrate dehydrogenase 0.0042 0.0585 0.0899
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0126 0.0121
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.011 0.1759 0.5736
Leishmania major protein kinase, putative 0.0034 0.0449 0.1786
Trichomonas vaginalis CMGC family protein kinase 0.0057 0.084 0.1927
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.011 0.1759 0.5736
Echinococcus multilocularis caspase 8 0.0019 0.0187 0.0608
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0183 0.0074
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0183 0.0179
Echinococcus granulosus mitogen activated protein kinase 3 0.0057 0.084 0.2739
Echinococcus multilocularis solute carrier family 22 0.0015 0.0126 0.0409
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0187 0.0165
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0015 0.0126 0.0197
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.012 0.1936 1
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0042 0.0585 0.2538
Trypanosoma brucei PAB1-binding protein , putative 0.0037 0.0489 0.201
Loa Loa (eye worm) hypothetical protein 0.0015 0.0126 0.0121
Mycobacterium tuberculosis Conserved protein 0.0063 0.0949 0.1229
Plasmodium vivax 6-phosphofructokinase, putative 0.0032 0.042 0.0377
Loa Loa (eye worm) hypothetical protein 0.0015 0.0126 0.0121
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0008 0.0005 0.0007
Brugia malayi beta-lactamase 0.0063 0.0949 0.0944
Echinococcus multilocularis solute carrier family 22 0.0015 0.0126 0.0409
Loa Loa (eye worm) hypothetical protein 0.0063 0.0949 0.0944
Entamoeba histolytica phosphofructokinase, putative 0.012 0.1936 1
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0042 0.0585 0.2538
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.042 0.0793
Leishmania major ATP-dependent phosphofructokinase 0.012 0.1936 1
Schistosoma mansoni caspase-3 (C14 family) 0.0019 0.0187 0.0275
Brugia malayi 6-phosphofructokinase 0.012 0.1936 0.1932
Trichomonas vaginalis phosphofructokinase, putative 0.012 0.1936 0.4883
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0587 1 1
Schistosoma mansoni hypothetical protein 0.0401 0.6791 1
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0369 0.1202
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0034 0.0449 0.0444
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0178 0.2939 0.5503
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0042 0.0585 0.1908
Plasmodium falciparum calcium-dependent protein kinase 4 0.0034 0.0449 0.0414
Entamoeba histolytica hypothetical protein 0.0042 0.0581 0.2269
Loa Loa (eye worm) hypothetical protein 0.0013 0.0075 0.007
Loa Loa (eye worm) isocitrate dehydrogenase 0.0042 0.0585 0.0581
Brugia malayi Sugar transporter family protein 0.0015 0.0126 0.0121
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0034 0.0449 0.1464
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0063 0.0949 0.2657
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0061 0.0908 0.4322
Toxoplasma gondii phosphofructokinase PFKII 0.0032 0.042 0.0575
Echinococcus granulosus 6 phosphofructokinase 0.012 0.1936 0.6313
Trypanosoma brucei glucose transporter, putative 0.0034 0.0448 0.178
Trichomonas vaginalis CMGC family protein kinase 0.0057 0.084 0.1927
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0034 0.0449 0.1464
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.011 0.1759 0.5736
Echinococcus granulosus Sugar transporter ERD6 protein 0.0015 0.0126 0.0409
Trichomonas vaginalis glutaminase, putative 0.0205 0.3405 0.8844
Giardia lamblia Kinase, CMGC MAPK 0.0057 0.084 1
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0033 0.0429 0.0817
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0019 0.0187 0.0119
Loa Loa (eye worm) major facilitator superfamily transporter 0.0015 0.0126 0.0121
Entamoeba histolytica hypothetical protein 0.0042 0.0581 0.2269
Brugia malayi Sugar transporter family protein 0.0015 0.0126 0.0121
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0126 0.0121
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0743 0.1094
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0019 0.0187 0.0165
Loa Loa (eye worm) beta-lactamase 0.0063 0.0949 0.0944
Trypanosoma brucei glucose transporter, putative 0.0034 0.0448 0.178
Loa Loa (eye worm) hypothetical protein 0.0015 0.0126 0.0121
Trypanosoma cruzi metacaspase, putative 0.0019 0.0187 0.0337
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0183 0.0156
Loa Loa (eye worm) hypothetical protein 0.0033 0.0429 0.0424
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.042 0.0793
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0038 0.0523 0.2195
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0034 0.0449 0.1786
Echinococcus granulosus intermediate filament protein 0.0027 0.0325 0.1058
Schistosoma mansoni smad 0.0008 0.0005 0.0007
Echinococcus granulosus solute carrier family 22 0.0015 0.0126 0.0409
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0743 0.1094
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0034 0.0449 0.0414
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0126 0.0121
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0034 0.0449 0.1464
Brugia malayi phosphofructokinase 0.012 0.1936 0.1932
Brugia malayi 6-phosphofructokinase 0.012 0.1936 0.1932
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.0817 0.1354
Plasmodium falciparum ataxin-2 like protein, putative 0.0037 0.0489 0.0466
Echinococcus granulosus caspase 0.0019 0.0187 0.0608
Loa Loa (eye worm) hypothetical protein 0.0015 0.0126 0.0121
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0034 0.0449 0.0633
Schistosoma mansoni hypothetical protein 0.0186 0.3067 0.4516
Schistosoma mansoni intermediate filament proteins 0.0027 0.0325 0.0478
Mycobacterium ulcerans 6-phosphofructokinase 0.012 0.1936 0.5609
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0019 0.0187 0.0165
Loa Loa (eye worm) sugar transporter 0.011 0.1759 0.1755
Leishmania major hypothetical protein, conserved 0.0037 0.0489 0.201
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0034 0.0449 0.1464
Echinococcus granulosus mitogen activated protein kinase 0.0057 0.084 0.2739
Echinococcus multilocularis mitogen activated protein kinase 3 0.0057 0.084 0.2739
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.042 0.0793
Leishmania major hypothetical protein, conserved 0.0063 0.0949 0.4546
Schistosoma mansoni hypothetical protein 0.011 0.1759 0.259
Echinococcus multilocularis apoptotic protease activating factor 1 0.0044 0.0623 0.203
Echinococcus multilocularis geminin 0.0164 0.2694 0.8783
Plasmodium falciparum calcium-dependent protein kinase 1 0.0034 0.0449 0.0414
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0032 0.042 0.1348
Trichomonas vaginalis glucose transporter, putative 0.0034 0.0448 0.0869
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0186 0.3067 1
Onchocerca volvulus 0.0063 0.0949 0.222
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0015 0.0126 0.0197
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0183 0.0598
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0033 0.0429 0.1222
Mycobacterium tuberculosis Probable hydrolase 0.0063 0.0949 0.1229
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0032 0.042 0.0575
Trichomonas vaginalis D-aminoacylase, putative 0.0063 0.0949 0.222
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0187 0.0165
Loa Loa (eye worm) hypothetical protein 0.0015 0.0126 0.0121
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.012 0.1936 0.2703
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0178 0.2939 0.3602
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0183 0.032
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0057 0.084 0.3946
Chlamydia trachomatis lysine--tRNA ligase 0.0025 0.0283 0.6191
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0057 0.084 0.3946
Echinococcus multilocularis lamin 0.0027 0.0325 0.1058
Schistosoma mansoni hypothetical protein 0.0186 0.3067 0.4516
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0034 0.0449 0.1464
Trypanosoma brucei glucose transporter, putative 0.0034 0.0448 0.178
Trichomonas vaginalis esterase, putative 0.0063 0.0949 0.222
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0057 0.084 0.3946
Loa Loa (eye worm) hypothetical protein 0.0015 0.0126 0.0121
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0025 0.0283 0.0666
Brugia malayi Sugar transporter family protein 0.011 0.1759 0.1755
Plasmodium falciparum protein kinase 6 0.0467 0.7935 1
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0042 0.0585 0.2538
Schistosoma mansoni smad1 5 8 and 0.0008 0.0005 0.0007
Loa Loa (eye worm) 6-phosphofructokinase 0.012 0.1936 0.1932
Brugia malayi intermediate filament protein 0.0027 0.0325 0.032
Onchocerca volvulus 0.003 0.0369 0.0656
Schistosoma mansoni caspase-7 (C14 family) 0.0019 0.0187 0.0275
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0034 0.0449 0.0414
Trichomonas vaginalis sugar transporter, putative 0.0034 0.0448 0.0869
Echinococcus granulosus solute carrier family 22 0.0015 0.0126 0.0409
Schistosoma mansoni glucose transport protein 0.011 0.1759 0.259
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0183 0.0086
Brugia malayi hypothetical protein 0.0015 0.0126 0.0121
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0908 0.2536
Brugia malayi major facilitator superfamily protein 0.0015 0.0126 0.0121
Plasmodium vivax SET domain protein, putative 0.003 0.0369 0.0311
Schistosoma mansoni glucose transport protein 0.011 0.1759 0.259
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0369 0.1202
Echinococcus granulosus synaptic vesicle 2 protein 0.0015 0.0126 0.0409
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.003 0.0099
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0025 0.0283 0.0372
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0369 0.0543
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.011 0.1759 0.5736
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0019 0.0187 0.0165
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0063 0.0949 0.1229
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0022 0.023 0.0282
Schistosoma mansoni hypothetical protein 0.0042 0.0581 0.0856
Loa Loa (eye worm) hypothetical protein 0.0033 0.0429 0.0424
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0042 0.0585 0.1908
Echinococcus granulosus lamin dm0 0.0027 0.0325 0.1058
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0014 0.0092 0.0088
Onchocerca volvulus 0.0027 0.0325 0.0537
Loa Loa (eye worm) hypothetical protein 0.0027 0.0325 0.032
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0187 0.0165
Echinococcus granulosus Smad4 0.0008 0.0005 0.0016
Schistosoma mansoni protein kinase 0.0034 0.0449 0.0661
Loa Loa (eye worm) hypothetical protein 0.0063 0.0951 0.0947
Plasmodium vivax CDK-related protein kinase 6, putative 0.0467 0.7935 1
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0034 0.0449 0.1464
Echinococcus granulosus apoptotic protease activating factor 1 0.0044 0.0623 0.203
Echinococcus multilocularis mitogen activated protein kinase 0.0057 0.084 0.2739
Plasmodium falciparum protein kinase 7 0.0311 0.5238 0.6546
Echinococcus multilocularis isocitrate dehydrogenase 0.0042 0.0585 0.1908
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0908 0.1337
Loa Loa (eye worm) hypothetical protein 0.0044 0.0623 0.0618
Loa Loa (eye worm) hypothetical protein 0.0025 0.0283 0.0278
Trichomonas vaginalis phosphofructokinase, putative 0.012 0.1936 0.4883
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0057 0.084 0.3946
Trypanosoma cruzi metacaspase 5, putative 0.0019 0.0187 0.0337
Loa Loa (eye worm) hypothetical protein 0.0019 0.0187 0.0182
Mycobacterium tuberculosis Conserved protein 0.0063 0.0949 0.1229
Toxoplasma gondii LsmAD domain-containing protein 0.0037 0.0489 0.0712
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.042 0.0793
Trichomonas vaginalis CMGC family protein kinase 0.0057 0.084 0.1927
Plasmodium vivax proline--tRNA ligase, putative 0.0038 0.0523 0.0509
Schistosoma mansoni hypothetical protein 0.0016 0.0141 0.0208
Entamoeba histolytica phosphofructokinase, putative 0.012 0.1936 1
Plasmodium vivax hypothetical protein, conserved 0.0063 0.0949 0.1054
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0042 0.0585 0.0588
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0448 0.0869
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.0743 0.2422
Echinococcus granulosus General substrate transporter 0.0094 0.1492 0.4864
Echinococcus granulosus lamin 0.0027 0.0325 0.1058
Toxoplasma gondii isocitrate dehydrogenase 0.0042 0.0585 0.0899
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0034 0.0449 0.0414
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0051 0.0743 0.0738
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0057 0.084 0.3946
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0019 0.0187 0.0608
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0019 0.0187 0.0275
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0187 0.0165
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0183 0.032
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0057 0.084 0.0836
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0032 0.042 0.4116
Echinococcus multilocularis musashi 0.0027 0.0325 0.1058
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0042 0.0585 0.1908
Plasmodium vivax ataxin-2 like protein, putative 0.0037 0.0489 0.0466
Plasmodium falciparum metacaspase-like protein 0.0019 0.0187 0.0078
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.093 0.1369
Brugia malayi hypothetical protein 0.0015 0.0126 0.0121
Schistosoma mansoni cpg binding protein 0.003 0.0383 0.0564
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0034 0.0449 0.0633
Schistosoma mansoni glucose transport protein 0.011 0.1759 0.259
Brugia malayi hypothetical protein 0.0037 0.0489 0.0485
Mycobacterium ulcerans sugar transporter 0.0015 0.0126 0.0197
Loa Loa (eye worm) histone methyltransferase 0.001 0.003 0.0025
Toxoplasma gondii 6-phosphofructokinase 0.0032 0.042 0.0575
Schistosoma mansoni glutaminase 0.0205 0.3405 0.5015
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.0743 0.2422
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0015 0.0126 0.0185
Loa Loa (eye worm) hypothetical protein 0.0587 1 1
Schistosoma mansoni serine/threonine protein kinase 0.0057 0.084 0.1237
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0021 0.0219 0.0139
Onchocerca volvulus 0.023 0.3834 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0489 0.0485
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0019 0.0187 0.0165
Trypanosoma brucei glucose transporter, putative 0.0034 0.0448 0.178
Schistosoma mansoni hypothetical protein 0.0186 0.3067 0.4516
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0042 0.0585 0.2538
Trichomonas vaginalis CAMK family protein kinase 0.0034 0.0449 0.0872
Brugia malayi Cam kinase protein 1 0.0034 0.0449 0.0444
Plasmodium vivax metacaspase 1, putative 0.0019 0.0187 0.0078
Entamoeba histolytica protein kinase, putative 0.0034 0.0449 0.1514
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.034 0.1107
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0369 0.1202
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0183 0.0156
Mycobacterium tuberculosis Probable esterase LipL 0.0063 0.0949 0.1229
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0083 0.0272
Brugia malayi beta-lactamase family protein 0.0063 0.0949 0.0944
Plasmodium vivax hexose transporter 0.011 0.1759 0.2092
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0028 0.0023
Mycobacterium ulcerans beta-lactamase 0.0063 0.0949 0.2657
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0187 0.0165
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0325 0.032
Loa Loa (eye worm) hypothetical protein 0.0063 0.0949 0.0944
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0183 0.032
Echinococcus granulosus smad 0.0008 0.0005 0.0016
Schistosoma mansoni lysyl-tRNA synthetase 0.0025 0.0283 0.0416
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0042 0.0585 0.1908
Schistosoma mansoni cpg binding protein 0.003 0.0383 0.0564
Trypanosoma brucei glucose transporter 1E 0.0034 0.0448 0.178
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0743 0.1094
Schistosoma mansoni glucose transporter 0.0015 0.0126 0.0185
Trichomonas vaginalis D-aminoacylase, putative 0.0063 0.0949 0.222
Mycobacterium ulcerans hypothetical protein 0.0063 0.0949 0.2657
Loa Loa (eye worm) hypothetical protein 0.003 0.0369 0.0364
Echinococcus multilocularis lysyl tRNA synthetase 0.0025 0.0283 0.0921
Leishmania major lysyl-tRNA synthetase, putative 0.0025 0.0283 0.0867
Trypanosoma brucei THT1 - hexose transporter, putative 0.0034 0.0448 0.178
Schistosoma mansoni hypothetical protein 0.0186 0.3067 0.4516
Loa Loa (eye worm) glutaminase 0.0205 0.3405 0.3402
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0063 0.0949 0.1397
Echinococcus multilocularis smad 0.0008 0.0005 0.0016
Trypanosoma brucei THT1 - hexose transporter, putative 0.0034 0.0448 0.178
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0057 0.084 0.1398
Echinococcus multilocularis caspase 0.0019 0.0187 0.0608
Trypanosoma brucei glucose transporter 2A 0.0034 0.0448 0.178
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0183 0.032
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0061 0.0908 0.2961
Trypanosoma brucei glucose transporter, putative 0.0034 0.0448 0.178
Trichomonas vaginalis penicillin-binding protein, putative 0.0063 0.0949 0.222
Plasmodium falciparum ataxin-2 like protein, putative 0.0037 0.0489 0.0466
Brugia malayi glutaminase DH11.1 0.0205 0.3405 0.3402
Trichomonas vaginalis phosphofructokinase, putative 0.012 0.1936 0.4883
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0032 0.042 0.1918
Echinococcus granulosus TGF beta signal transducer SmadC 0.0008 0.0005 0.0016
Schistosoma mansoni Smad4 0.0008 0.0005 0.0007
Brugia malayi Cell death protein 3 precursor 0.0063 0.0951 0.0947
Loa Loa (eye worm) phosphofructokinase 0.012 0.1936 0.1932
Echinococcus granulosus mothers against decapentaplegic 5 0.0008 0.0005 0.0016
Echinococcus granulosus lysyl tRNA synthetase 0.0025 0.0283 0.0921
Trypanosoma cruzi hexose transporter, putative 0.0019 0.0181 0.0304
Entamoeba histolytica protein kinase, putative 0.0034 0.0449 0.1514
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0025 0.0283 0.0423
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0063 0.0949 0.1397
Mycobacterium ulcerans glutaminase 0.0205 0.3405 1
Brugia malayi hypothetical protein 0.0024 0.0266 0.0261
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0051 0.0743 0.0738
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0183 0.0179
Loa Loa (eye worm) hypothetical protein 0.0034 0.0449 0.0444
Loa Loa (eye worm) major facilitator superfamily transporter 0.0015 0.0126 0.0121
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0034 0.0449 0.0633
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0038 0.0523 0.0778
Onchocerca volvulus 0.0027 0.0325 0.0537
Brugia malayi Latrophilin receptor protein 2 0.0186 0.3067 0.3064
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0019 0.0187 0.0165
Plasmodium falciparum calcium-dependent protein kinase 3 0.0034 0.0449 0.0414
Trypanosoma brucei metacaspase MCA2 0.0019 0.0187 0.0337
Trichomonas vaginalis set domain proteins, putative 0.023 0.3834 1
Onchocerca volvulus 0.0029 0.0355 0.0618
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0042 0.0585 0.0862
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0032 0.042 0.0377
Trypanosoma cruzi metacaspase, putative 0.0019 0.0187 0.0337
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0019 0.0187 0.0165
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0369 0.0543
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0016 0.0141 0.0461
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0033 0.0429 0.0424
Brugia malayi Pre-SET motif family protein 0.0202 0.3353 0.335
Brugia malayi latrophilin 2 splice variant baaae 0.0401 0.6791 0.679
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.012 0.1936 1
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0033 0.0429 0.0424
Schistosoma mansoni hypothetical protein 0.0164 0.2694 0.3967
Schistosoma mansoni sugar transporter 0.0015 0.0126 0.0185
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0025 0.0283 0.0867
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0183 0.0598
Loa Loa (eye worm) hypothetical protein 0.0013 0.0075 0.007
Schistosoma mansoni ap endonuclease 0.0019 0.0183 0.027
Schistosoma mansoni sugar transporter 0.0015 0.0126 0.0185
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0032 0.042 1
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0019 0.0187 0.0165
Loa Loa (eye worm) MH2 domain-containing protein 0.0124 0.201 0.2006
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.011 0.1759 0.5736
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0015 0.0126 0.0409
Trypanosoma cruzi PAB1-binding protein , putative 0.0037 0.0489 0.201
Echinococcus multilocularis Smad4 0.0008 0.0005 0.0016
Mycobacterium ulcerans esterase/lipase LipP 0.0063 0.0949 0.2657
Trypanosoma cruzi hexose transporter, putative 0.0034 0.0448 0.178
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0908 0.2536
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0038 0.0523 0.2195
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0061 0.0908 0.2961
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0019 0.0187 0.0608
Brugia malayi hypothetical protein 0.0044 0.0623 0.0618
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0183 0.081
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0183 0.037
Mycobacterium leprae Probable lipase LipE 0.0063 0.0949 0.425
Toxoplasma gondii lysine-tRNA ligase 0.0025 0.0283 0.0307
Brugia malayi beta-lactamase family protein 0.0063 0.0949 0.0944
Toxoplasma gondii ABC1 family protein 0.0063 0.0949 0.161
Loa Loa (eye worm) hypothetical protein 0.0015 0.0126 0.0121
Echinococcus multilocularis caspase 2 0.0063 0.0951 0.3101
Mycobacterium leprae conserved hypothetical protein 0.0063 0.0949 0.425
Trypanosoma cruzi metacaspase 5, putative 0.0019 0.0187 0.0337
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0032 0.042 0.0377
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0021 0.0219 0.0139
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0183 1
Trypanosoma cruzi hypothetical protein, conserved 0.0063 0.0949 0.4546
Trypanosoma brucei hypothetical protein, conserved 0.0063 0.0949 0.4546
Loa Loa (eye worm) hypothetical protein 0.0015 0.0126 0.0121
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0063 0.0949 0.1229
Trypanosoma brucei THT1 - hexose transporter, putative 0.0034 0.0448 0.178
Plasmodium falciparum calcium-dependent protein kinase 2 0.0034 0.0449 0.0414
Loa Loa (eye worm) hypothetical protein 0.0015 0.0126 0.0121
Trypanosoma brucei glucose transporter, putative 0.0034 0.0448 0.178
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0042 0.0585 0.1908
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0033 0.0429 0.1397
Trypanosoma cruzi metacaspase, putative 0.0019 0.0187 0.0337
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0016 0.0141 0.0461
Brugia malayi MH2 domain containing protein 0.0124 0.201 0.2006
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.012 0.1936 1
Giardia lamblia Prolyl-tRNA synthetase 0.0033 0.0429 0.424
Echinococcus granulosus caspase 2 0.0063 0.0951 0.3101
Schistosoma mansoni hypothetical protein 0.0044 0.0623 0.0917
Brugia malayi Isocitrate dehydrogenase 0.0042 0.0585 0.0581
Trichomonas vaginalis penicillin-binding protein, putative 0.0063 0.0949 0.222
Toxoplasma gondii aldehyde dehydrogenase 0.0061 0.0908 0.1531
Loa Loa (eye worm) hypothetical protein 0.0015 0.0126 0.0121
Brugia malayi hypothetical protein 0.0042 0.0581 0.0577
Echinococcus multilocularis 6 phosphofructokinase 0.012 0.1936 0.6313
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0042 0.0581 0.1895
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0063 0.0949 0.1229
Entamoeba histolytica hypothetical protein 0.0025 0.0283 0.0565
Trypanosoma brucei Metacaspase-4 0.0019 0.0187 0.0337
Schistosoma mansoni serine/threonine protein kinase 0.0034 0.0449 0.0661
Loa Loa (eye worm) hypothetical protein 0.0015 0.0126 0.0121
Loa Loa (eye worm) hypothetical protein 0.0015 0.0126 0.0121
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0038 0.0523 0.2195
Trichomonas vaginalis sugar transporter, putative 0.0034 0.0448 0.0869
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0325 0.032
Trypanosoma cruzi hexose transporter, putative 0.0034 0.0448 0.178
Plasmodium vivax calcium-dependent protein kinase, putative 0.0034 0.0449 0.0414

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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