Detailed information for compound 71432

Basic information

Technical information
  • TDR Targets ID: 71432
  • Name: N-phenylacridin-9-amine
  • MW: 270.328 | Formula: C19H14N2
  • H donors: 1 H acceptors: 1 LogP: 5.07 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: c1ccc(cc1)Nc1c2ccccc2nc2c1cccc2
  • InChi: 1S/C19H14N2/c1-2-8-14(9-3-1)20-19-15-10-4-6-12-17(15)21-18-13-7-5-11-16(18)19/h1-13H,(H,20,21)
  • InChiKey: LNVQBBHYPGFSMX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-phenyl-9-acridinamine
  • acridin-9-yl(phenyl)amine
  • 9-anilinoacridine
  • acridin-9-yl-phenyl-amine
  • 3340-22-5
  • 9-Acridinamine, N-phenyl-
  • ZINC03899979
  • 5-22-11-00011 (Beilstein Handbook Reference)
  • 9-(Phenylamino)acridine
  • 9-Acridinamine, N-phenyl- (9CI)
  • ACRIDINE, 9-ANILINO-
  • BRN 0210868

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Leishmania major DNA topoisomerase ii Curated by TDR Targets References
Leishmania major mitochondrial DNA topoisomerase II Curated by TDR Targets References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium falciparum DNA topoisomerase 2 Get druggable targets OG5_127113 All targets in OG5_127113
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein Get druggable targets OG5_128755 All targets in OG5_128755
Trypanosoma brucei gambiense DNA topoisomerase II, putative Get druggable targets OG5_127113 All targets in OG5_127113
Onchocerca volvulus DNA topoisomerase 2 homolog Get druggable targets OG5_127113 All targets in OG5_127113
Leishmania infantum DNA topoisomerase ii Get druggable targets OG5_127113 All targets in OG5_127113
Plasmodium berghei DNA topoisomerase 2, putative Get druggable targets OG5_127113 All targets in OG5_127113
Leishmania mexicana mitochondrial DNA topoisomerase II Get druggable targets OG5_128755 All targets in OG5_128755
Neospora caninum hypothetical protein Get druggable targets OG5_127113 All targets in OG5_127113
Plasmodium knowlesi DNA gyrase subunit B, putative Get druggable targets OG5_128755 All targets in OG5_128755
Chlamydia trachomatis DNA gyrase subunit B Get druggable targets OG5_127113 All targets in OG5_127113
Leishmania major DNA topoisomerase ii Get druggable targets OG5_127113 All targets in OG5_127113
Giardia lamblia DNA topoisomerase II Get druggable targets OG5_127113 All targets in OG5_127113
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127113 All targets in OG5_127113
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127113 All targets in OG5_127113
Plasmodium berghei DNA gyrase subunit B, putative Get druggable targets OG5_128755 All targets in OG5_128755
Echinococcus granulosus DNA topoisomerase 2 alpha Get druggable targets OG5_127113 All targets in OG5_127113
Schistosoma mansoni DNA topoisomerase II Get druggable targets OG5_127113 All targets in OG5_127113
Trypanosoma brucei DNA topoisomerase II alpha, putative Get druggable targets OG5_127113 All targets in OG5_127113
Trypanosoma brucei gambiense DNA topoisomerase II, putative Get druggable targets OG5_128755 All targets in OG5_128755
Brugia malayi DNA topoisomerase II, alpha isozyme Get druggable targets OG5_127113 All targets in OG5_127113
Leishmania mexicana DNA topoisomerase ii Get druggable targets OG5_127113 All targets in OG5_127113
Schistosoma japonicum expressed protein Get druggable targets OG5_127113 All targets in OG5_127113
Schistosoma japonicum ko:K03164 DNA topoisomerase II, putative Get druggable targets OG5_127113 All targets in OG5_127113
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative Get druggable targets OG5_128755 All targets in OG5_128755
Trypanosoma brucei DNA topoisomerase ii Get druggable targets OG5_128755 All targets in OG5_128755
Babesia bovis DNA gyrase subunit B, putative Get druggable targets OG5_128755 All targets in OG5_128755
Trypanosoma congolense DNA topoisomerase II, putative Get druggable targets OG5_128755 All targets in OG5_128755
Plasmodium vivax DNA gyrase subunit B, putative Get druggable targets OG5_128755 All targets in OG5_128755
Babesia bovis DNA topoisomerase II, putative Get druggable targets OG5_127113 All targets in OG5_127113
Leishmania braziliensis mitochondrial DNA topoisomerase II Get druggable targets OG5_128755 All targets in OG5_128755
Plasmodium yoelii DNA topoisomerase II, putative Get druggable targets OG5_128755 All targets in OG5_128755
Theileria parva DNA gyrase subunit B, putative Get druggable targets OG5_128755 All targets in OG5_128755
Neospora caninum hypothetical protein Get druggable targets OG5_128755 All targets in OG5_128755
Trypanosoma brucei DNA topoisomerase II beta, putative Get druggable targets OG5_127113 All targets in OG5_127113
Wolbachia endosymbiont of Brugia malayi DNA gyrase, topoisomerase II, B subunit, GyrB Get druggable targets OG5_128755 All targets in OG5_128755
Candida albicans DNA topoisomerase II similar to S. cerevisiae TOP2 (YNL088W) Get druggable targets OG5_127113 All targets in OG5_127113
Theileria parva DNA topoisomerase II, putative Get druggable targets OG5_127113 All targets in OG5_127113
Leishmania donovani DNA topoisomerase ii Get druggable targets OG5_127113 All targets in OG5_127113
Cryptosporidium parvum DNA topoisomerase II Get druggable targets OG5_127113 All targets in OG5_127113
Trypanosoma congolense DNA topoisomerase II, putative Get druggable targets OG5_127113 All targets in OG5_127113
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein Get druggable targets OG5_127113 All targets in OG5_127113
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127113 All targets in OG5_127113
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127113 All targets in OG5_127113
Mycobacterium ulcerans DNA gyrase subunit B Get druggable targets OG5_128755 All targets in OG5_128755
Trypanosoma brucei gambiense DNA topoisomerase II, putative Get druggable targets OG5_127113 All targets in OG5_127113
Onchocerca volvulus DNA topoisomerase 2 homolog Get druggable targets OG5_127113 All targets in OG5_127113
Plasmodium knowlesi DNA topoisomerase 2, putative Get druggable targets OG5_127113 All targets in OG5_127113
Trichomonas vaginalis DNA topoisomerase II, putative Get druggable targets OG5_127113 All targets in OG5_127113
Entamoeba histolytica DNA topoisomerase II, putative Get druggable targets OG5_127113 All targets in OG5_127113
Plasmodium yoelii DNA topoisomerase II, putative Get druggable targets OG5_127113 All targets in OG5_127113
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127113 All targets in OG5_127113
Trypanosoma cruzi DNA topoisomerase II, putative Get druggable targets OG5_127113 All targets in OG5_127113
Mycobacterium tuberculosis DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) Get druggable targets OG5_128755 All targets in OG5_128755
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial Get druggable targets OG5_127113 All targets in OG5_127113
Loa Loa (eye worm) TOPoisomerase family member Get druggable targets OG5_127113 All targets in OG5_127113
Brugia malayi Probable DNA topoisomerase II Get druggable targets OG5_127113 All targets in OG5_127113
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127113 All targets in OG5_127113
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative Get druggable targets OG5_128755 All targets in OG5_128755
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127113 All targets in OG5_127113
Mycobacterium leprae Probable DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) Get druggable targets OG5_128755 All targets in OG5_128755
Leishmania infantum mitochondrial DNA topoisomerase II Get druggable targets OG5_128755 All targets in OG5_128755
Plasmodium falciparum DNA gyrase subunit B Get druggable targets OG5_128755 All targets in OG5_128755
Leishmania donovani mitochondrial DNA topoisomerase II Get druggable targets OG5_128755 All targets in OG5_128755
Treponema pallidum DNA gyrase, subunit B (gyrB) Get druggable targets OG5_128755 All targets in OG5_128755
Leishmania braziliensis DNA topoisomerase ii Get druggable targets OG5_127113 All targets in OG5_127113
Trypanosoma cruzi DNA topoisomerase II, putative Get druggable targets OG5_127113 All targets in OG5_127113
Candida albicans DNA topoisomerase II similar to S. cerevisiae TOP2 (YNL088W) Get druggable targets OG5_127113 All targets in OG5_127113
Chlamydia trachomatis DNA gyrase subunit B Get druggable targets OG5_128755 All targets in OG5_128755
Trypanosoma congolense DNA topoisomerase II, putative Get druggable targets OG5_127113 All targets in OG5_127113
Toxoplasma gondii DNA topoisomerase 2, putative Get druggable targets OG5_127113 All targets in OG5_127113
Cryptosporidium hominis DNA topoisomerase II Get druggable targets OG5_127113 All targets in OG5_127113
Echinococcus multilocularis DNA topoisomerase 2 alpha Get druggable targets OG5_127113 All targets in OG5_127113
Plasmodium vivax DNA topoisomerase II, putative Get druggable targets OG5_127113 All targets in OG5_127113
Leishmania major mitochondrial DNA topoisomerase II Get druggable targets OG5_128755 All targets in OG5_128755
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei DNA topoisomerase II beta, putative mitochondrial DNA topoisomerase II 1236 aa 1047 aa 35.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis conserved hypothetical protein 0.0119 0.0062 0.0377
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.2755 0.3941 0.3935
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0234 0.0232 0.2807
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0516 0.0647 0.8765
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0203 0.0185 0.0407
Echinococcus multilocularis somatostatin receptor 0.0283 0.0303 0.0294
Onchocerca volvulus 0.0283 0.0303 0.267
Leishmania major heat shock protein 83-1 0.0148 0.0105 0.0161
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0283 0.0303 0.0294
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0127 0.0074 0.0652
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0283 0.0303 0.0294
Schistosoma mansoni hypothetical protein 0.0283 0.0303 0.0845
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0348 0.0399 0.2425
Loa Loa (eye worm) hypothetical protein 0.0283 0.0303 0.0841
Echinococcus multilocularis sodium channel protein 0.0205 0.0189 0.0179
Entamoeba histolytica hypothetical protein 0.0117 0.0059 0.0332
Schistosoma mansoni hypothetical protein 0.0231 0.0226 0.0602
Entamoeba histolytica heat shock protein 90, putative 0.0148 0.0105 0.0991
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0169 0.0136 0.1279
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0334 0.0378 0.0369
Echinococcus multilocularis orexin receptor type 2 0.0283 0.0303 0.0294
Loa Loa (eye worm) hypothetical protein 0.0283 0.0303 0.0841
Echinococcus granulosus g protein coupled receptor 0.0283 0.0303 0.0294
Echinococcus granulosus heat shock protein 90 0.0148 0.0105 0.0095
Echinococcus granulosus neuropeptide receptor A26 0.2985 0.428 0.4274
Onchocerca volvulus 0.0257 0.0265 0.2333
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0169 0.0136 0.026
Brugia malayi Trypsin family protein 0.0319 0.0357 0.0989
Loa Loa (eye worm) hypothetical protein 0.0493 0.0613 0.1699
Schistosoma mansoni tubulin subunit beta 0.011 0.0048 0.0039
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0283 0.0303 0.0294
Trichomonas vaginalis PIKK family atypical protein kinase 0.0575 0.0733 1
Trypanosoma cruzi DNA topoisomerase II, putative 0.0173 0.0141 0.0276
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0101 0.0036 0.01
Entamoeba histolytica heat shock protein 90, putative 0.0148 0.0105 0.0991
Trypanosoma cruzi heat shock protein 90, putative 0.0122 0.0066 0.0053
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0113 0.0054 0.0016
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.0226 0.0219 0.0578
Loa Loa (eye worm) G-protein coupled receptor 0.0283 0.0303 0.0841
Trichomonas vaginalis heat shock protein, putative 0.0126 0.0073 0.0527
Leishmania major mitochondrial DNA topoisomerase II 0.0203 0.0185 0.0387
Onchocerca volvulus 0.0283 0.0303 0.267
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.0538 0.0678 0.0669
Echinococcus multilocularis Tubulin beta 2C chain 0.011 0.0048 0.0038
Toxoplasma gondii PAN domain-containing protein 0.1194 0.1644 1
Trichomonas vaginalis conserved hypothetical protein 0.0185 0.0159 0.1761
Schistosoma mansoni neuropeptide f receptor 76f 0.0283 0.0303 0.0845
Trypanosoma brucei C-8 sterol isomerase, putative 0.0362 0.0419 0.5417
Schistosoma mansoni amine GPCR 0.0283 0.0303 0.0845
Brugia malayi DNA topoisomerase II, alpha isozyme 0.0182 0.0155 0.0429
Trichomonas vaginalis glucosylceramidase, putative 0.0254 0.026 0.3216
Loa Loa (eye worm) hypothetical protein 0.0082 0.0007 0.002
Schistosoma mansoni amine GPCR 0.0283 0.0303 0.0845
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0094 0.0025 0.0015
Echinococcus multilocularis 3 phosphoinositide dependent protein kinase 1 0.0101 0.0036 0.0026
Schistosoma mansoni growth hormone secretagogue receptor 0.0283 0.0303 0.0845
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0283 0.0303 0.267
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.1255 0.1734 0.1726
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0314 0.0349 0.0339
Trichomonas vaginalis PIKK family atypical protein kinase 0.0314 0.0349 0.4486
Brugia malayi phosphoinositide-dependent protein kinase I 0.0101 0.0036 0.01
Trichomonas vaginalis PIKK family atypical protein kinase 0.0544 0.0688 0.9359
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0169 0.0136 0.0827
Loa Loa (eye worm) hypothetical protein 0.0163 0.0126 0.035
Schistosoma mansoni endoplasmin 0.0148 0.0105 0.0218
Trypanosoma brucei variant surface glycoprotein (VSG), putative 0.0113 0.0054 0.0077
Trichomonas vaginalis PIKK family atypical protein kinase 0.0332 0.0376 0.488
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0113 0.0054 0.0016
Echinococcus multilocularis endoplasmin 0.0126 0.0073 0.0063
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0169 0.0136 0.0316
Echinococcus granulosus rhodopsin orphan GPCR 0.0283 0.0303 0.0294
Schistosoma mansoni myosin xvIII 0.0283 0.0303 0.0845
Onchocerca volvulus 0.0283 0.0303 0.267
Onchocerca volvulus 0.0283 0.0303 0.267
Echinococcus granulosus jun protein 0.0094 0.0025 0.0015
Echinococcus multilocularis heat shock protein 0.0148 0.0105 0.0095
Echinococcus multilocularis neuropeptide receptor 0.0283 0.0303 0.0294
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.0145 0.1563
Brugia malayi brahma associated protein 60 kDa 0.0119 0.0062 0.0173
Loa Loa (eye worm) hypothetical protein 0.0283 0.0303 0.0841
Echinococcus granulosus sex peptide receptor 0.0283 0.0303 0.0294
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.6872 1 1
Trichomonas vaginalis glucosylceramidase, putative 0.0254 0.026 0.3216
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0126 0.0073 0.0063
Echinococcus granulosus tm gpcr rhodopsin 0.0283 0.0303 0.0294
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0117 0.0059 0.0332
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0283 0.0303 0.0841
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0127 0.0074 0.0652
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.0538 0.0678 0.0669
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0269 0.0283 0.0273
Loa Loa (eye worm) hypothetical protein 0.0283 0.0303 0.0841
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0169 0.0136 0.0377
Echinococcus granulosus tm gpcr rhodopsin 0.1808 0.2548 0.2541
Brugia malayi Endoplasmin precursor 0.0148 0.0105 0.0291
Echinococcus multilocularis tubulin subunit beta 0.011 0.0048 0.0038
Schistosoma mansoni serine/threonine protein kinase 0.019 0.0167 0.0413
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0692 0.0905 0.0895
Brugia malayi brahma associated protein 60 kDa 0.0119 0.0062 0.0173
Echinococcus multilocularis heat shock protein 90 0.0126 0.0073 0.0063
Echinococcus granulosus tachykinin peptides receptor 99D 0.0283 0.0303 0.0294
Schistosoma mansoni tubulin subunit beta 0.011 0.0048 0.0039
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0117 0.0059 0.0032
Trichomonas vaginalis PIKK family atypical protein kinase 0.0544 0.0688 0.9359
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0126 0.0073 1
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0234 0.0232 0.0618
Trichomonas vaginalis PIKK family atypical protein kinase 0.0554 0.0702 0.9556
Brugia malayi SWIB/MDM2 domain containing protein 0.0119 0.0062 0.0173
Trypanosoma cruzi hypothetical protein, conserved 0.2395 0.3411 1
Loa Loa (eye worm) hypothetical protein 0.0283 0.0303 0.0841
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0117 0.0059 0.0332
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0113 0.0054 0.0015
Echinococcus granulosus allatostatin A receptor 0.0849 0.1137 0.1127
Toxoplasma gondii DNA topoisomerase 2, putative 0.0182 0.0155 0.0941
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0169 0.0136 0.8233
Trichomonas vaginalis PIKK family atypical protein kinase 0.0197 0.0176 0.2012
Brugia malayi hypothetical protein 0.0283 0.0303 0.0841
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.0182 0.0155 0.0145
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0283 0.0303 0.0294
Echinococcus granulosus rhodopsin orphan GPCR 0.0283 0.0303 0.0294
Trichomonas vaginalis conserved hypothetical protein 0.0185 0.0159 0.1761
Brugia malayi map kinase activated protein kinase protein 2 0.019 0.0167 0.0462
Echinococcus granulosus rhodopsin orphan GPCR 0.0283 0.0303 0.0294
Loa Loa (eye worm) hypothetical protein 0.0231 0.0226 0.0627
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0169 0.0136 0.0377
Brugia malayi G-protein coupled receptor 0.0283 0.0303 0.0841
Echinococcus multilocularis fmrfamide receptor 0.0283 0.0303 0.0294
Echinococcus multilocularis beta tubulin 0.011 0.0048 0.0038
Loa Loa (eye worm) bone morphogenic protein 6 0.0125 0.0071 0.0198
Schistosoma mansoni opsin-like receptor 0.0283 0.0303 0.0845
Leishmania major heat shock protein 83-1 0.0148 0.0105 0.0161
Trichomonas vaginalis PIKK family atypical protein kinase 0.0556 0.0705 0.9606
Schistosoma mansoni hypothetical protein 0.0119 0.0062 0.0083
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0319 0.0357 0.1015
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0117 0.0059 0.0073
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0226 0.0219 0.2624
Echinococcus multilocularis neuropeptide receptor 0.0283 0.0303 0.0294
Trichomonas vaginalis heat shock protein, putative 0.0126 0.0073 0.0527
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0283 0.0303 0.0841
Brugia malayi Melatonin receptor type 1A 0.0283 0.0303 0.0841
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0117 0.0059 0.1025
Echinococcus granulosus neuropeptides capa receptor 0.0283 0.0303 0.0294
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.0173 0.0141 0.1358
Loa Loa (eye worm) hypothetical protein 0.0283 0.0303 0.0841
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.0132 0.1374
Trichomonas vaginalis PIKK family atypical protein kinase 0.0563 0.0715 0.9753
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0595 0.0763 0.2116
Trypanosoma cruzi heat shock protein 85, putative 0.0148 0.0105 0.0169
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0283 0.0303 0.0845
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0283 0.0303 0.0845
Echinococcus multilocularis 0.0117 0.0059 0.0049
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0623 0.0803 0.0794
Echinococcus granulosus 7tm_1 domain containing protein 0.0283 0.0303 0.0294
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0283 0.0303 0.0841
Mycobacterium ulcerans DNA gyrase subunit B 0.0112 0.0051 0.6692
Schistosoma mansoni hypothetical protein 0.0623 0.0803 0.2426
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0234 0.0232 0.2807
Echinococcus multilocularis neuropeptide Y receptor 0.0283 0.0303 0.0294
Schistosoma mansoni glutamate receptor NMDA 0.0269 0.0283 0.0781
Loa Loa (eye worm) endoplasmin 0.0148 0.0105 0.0291
Trichomonas vaginalis PIKK family atypical protein kinase 0.0554 0.0702 0.9555
Schistosoma mansoni hypothetical protein 0.0117 0.0059 0.0073
Onchocerca volvulus 0.0849 0.1137 1
Trypanosoma brucei RNA helicase, putative 0.0114 0.0055 0.0092
Trypanosoma cruzi heat shock protein 90, putative 0.0148 0.0105 0.0169
Echinococcus multilocularis g-protein coupled receptor 0.0283 0.0303 0.0294
Loa Loa (eye worm) proprotein convertase 2 0.0226 0.0219 0.0607
Leishmania major heat shock protein 83-1 0.0148 0.0105 0.0161
Schistosoma mansoni neuropeptide F-like receptor 0.0283 0.0303 0.0845
Leishmania major heat shock protein 83-1 0.0148 0.0105 0.0161
Loa Loa (eye worm) hypothetical protein 0.0283 0.0303 0.0841
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0283 0.0303 0.0294
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0205 0.0189 0.0179
Echinococcus granulosus biogenic amine 5HT receptor 0.0283 0.0303 0.0294
Trichomonas vaginalis PIKK family atypical protein kinase 0.0126 0.0073 0.0529
Schistosoma mansoni tyrosine kinase 0.0135 0.0086 0.0158
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0575 0.0733 0.2035
Echinococcus multilocularis Tubulin beta 2C chain 0.011 0.0048 0.0038
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0283 0.0303 0.0845
Toxoplasma gondii beta tubulin 0.011 0.0048 0.0294
Loa Loa (eye worm) hypothetical protein 0.0283 0.0303 0.0841
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0094 0.0025 0.0015
Loa Loa (eye worm) hypothetical protein 0.0283 0.0303 0.0841
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0113 0.0054 0.0016
Loa Loa (eye worm) hypothetical protein 0.0117 0.0059 0.0164
Trypanosoma brucei heat shock protein, putative 0.0148 0.0105 0.083
Trichomonas vaginalis tubulin epsilon chain, putative 0.011 0.0048 0.0176
Leishmania major heat shock protein 83-1 0.0148 0.0105 0.0161
Echinococcus granulosus sodium channel protein 0.0205 0.0189 0.0179
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0117 0.0059 0.036
Trichomonas vaginalis PIKK family atypical protein kinase 0.0329 0.037 0.48
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0283 0.0303 0.0294
Echinococcus granulosus orexin receptor type 2 0.0283 0.0303 0.0294
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0575 0.0733 1
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0117 0.0059 0.0032
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0283 0.0303 0.0845
Brugia malayi hypothetical protein 0.0283 0.0303 0.0841
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.0119 0.0062 0.1319
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0283 0.0303 0.0294
Brugia malayi G protein-coupled receptor F59B2.13 0.0283 0.0303 0.0841
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0283 0.0303 0.0294
Loa Loa (eye worm) hypothetical protein 0.0283 0.0303 0.0841
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.022 0.0211 0.0584
Trichomonas vaginalis tubulin gamma chain, putative 0.011 0.0048 0.0176
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0538 0.0678 0.9219
Leishmania major heat shock protein 83-1 0.0148 0.0105 0.0161
Echinococcus multilocularis neuropeptides capa receptor 0.0283 0.0303 0.0294
Schistosoma mansoni hypothetical protein 0.0185 0.0159 0.0388
Loa Loa (eye worm) phosphatidylinositol 3 0.0575 0.0733 0.2031
Trichomonas vaginalis PIKK family atypical protein kinase 0.0554 0.0702 0.9555
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0623 0.0803 0.0794
Brugia malayi neuroendocrine convertase 1 precursor 0.0555 0.0704 0.1951
Brugia malayi endoprotease bli-4 precursor 0.0867 0.1163 0.3224
Giardia lamblia GTOR 0.0575 0.0733 1
Echinococcus multilocularis Upstream activation factor subunit UAF30 0.0119 0.0062 0.0052
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0117 0.0059 0.0032
Trichomonas vaginalis PIKK family atypical protein kinase 0.0344 0.0393 0.5127
Brugia malayi hypothetical protein 0.0283 0.0303 0.0841
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.1255 0.1734 0.1726
Echinococcus granulosus rhodopsin orphan GPCR 0.0283 0.0303 0.0294
Entamoeba histolytica tubulin family protein 0.011 0.0048 0.0176
Loa Loa (eye worm) hypothetical protein 0.0283 0.0303 0.0841
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0117 0.0059 0.0049
Brugia malayi AKH receptor 0.0283 0.0303 0.0841
Trypanosoma brucei heat shock protein 90, putative 0.0148 0.0105 0.083
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0352 0.0404 0.52
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.1808 0.2548 0.2541
Giardia lamblia Furin precursor putative serine protease 0.0185 0.0159 0.1614
Plasmodium vivax DNA topoisomerase II, putative 0.0182 0.0155 1
Trypanosoma brucei DNA topoisomerase ii 0.0203 0.0185 0.1998
Schistosoma mansoni amine GPCR 0.0283 0.0303 0.0845
Schistosoma mansoni furin-1 (S08 family) 0.037 0.0432 0.1252
Toxoplasma gondii FATC domain-containing protein 0.0329 0.037 0.2253
Echinococcus multilocularis anti dorsalizing morphogenetic protein 1a 0.0125 0.0071 0.0061
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0283 0.0303 0.0845
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0117 0.0059 0.0049
Leishmania major phosphatidylinositol 3-kinase, putative 0.0544 0.0688 0.181
Schistosoma mansoni hypothetical protein 0.0114 0.0055 0.0059
Loa Loa (eye worm) hypothetical protein 0.0082 0.0007 0.002
Trichomonas vaginalis PIKK family atypical protein kinase 0.0332 0.0376 0.488
Echinococcus granulosus DNA topoisomerase 2 alpha 0.0182 0.0155 0.0145
Trichomonas vaginalis PIKK family atypical protein kinase 0.0544 0.0688 0.9359
Loa Loa (eye worm) melatonin receptor type 1A 0.0283 0.0303 0.0841
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0169 0.0136 0.0827
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0169 0.0136 0.0126
Loa Loa (eye worm) phosphatidylinositol 3 0.0627 0.0809 0.2242
Loa Loa (eye worm) hypothetical protein 0.0283 0.0303 0.0841
Loa Loa (eye worm) hypothetical protein 0.0319 0.0357 0.0989
Brugia malayi sulfakinin receptor protein 0.0493 0.0613 0.1699
Loa Loa (eye worm) phosphatidylinositol 3 0.0117 0.0059 0.0164
Entamoeba histolytica DNA topoisomerase II, putative 0.0182 0.0155 0.1703
Brugia malayi putative neuropeptide receptor NPR1 0.0283 0.0303 0.0841
Brugia malayi G protein-coupled receptor 0.0283 0.0303 0.0841
Loa Loa (eye worm) phosphatidylinositol 3 0.0555 0.0704 0.1952
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0113 0.0054 0.0077
Brugia malayi celfurPC protein 0.0683 0.0891 0.2471
Echinococcus multilocularis tubulin, beta 4A class IVa 0.011 0.0048 0.0038
Schistosoma mansoni hypothetical protein 0.0283 0.0303 0.0845
Onchocerca volvulus Neuropeptide F receptor homolog 0.0283 0.0303 0.267
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0117 0.0059 0.0049
Echinococcus multilocularis rhodopsin orphan GPCR 0.0283 0.0303 0.0294
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0226 0.0219 0.2624
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0314 0.0349 0.0966
Loa Loa (eye worm) hypothetical protein 0.0283 0.0303 0.0841
Echinococcus granulosus g protein coupled receptor 0.0283 0.0303 0.0294
Echinococcus multilocularis neuropeptide Y receptor 0.0283 0.0303 0.0294
Loa Loa (eye worm) pigment dispersing factor receptor c 0.1896 0.2677 0.7419
Brugia malayi beta-tubulin, identical 0.011 0.0048 0.0134
Brugia malayi Dopamine receptor protein 1 0.0283 0.0303 0.0841
Trichomonas vaginalis PIKK family atypical protein kinase 0.0554 0.0702 0.9556
Echinococcus granulosus Upstream activation factor subunit UAF30 0.0119 0.0062 0.0052
Trichomonas vaginalis PIKK family atypical protein kinase 0.0563 0.0715 0.9753
Echinococcus granulosus Tubulin beta 2C chain 0.011 0.0048 0.0038
Toxoplasma gondii beta-tubulin, putative 0.011 0.0048 0.0294
Trichomonas vaginalis PIKK family atypical protein kinase 0.0565 0.0719 0.9803
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0595 0.0763 0.0754
Trypanosoma brucei heat shock protein 90, putative 0.0148 0.0105 0.083
Trichomonas vaginalis PIKK family atypical protein kinase 0.0565 0.0719 0.9803
Brugia malayi Serotonin receptor 0.0283 0.0303 0.0841
Schistosoma mansoni tubulin subunit beta 0.011 0.0048 0.0039
Plasmodium falciparum heat shock protein 90 0.0148 0.0105 0.5342
Echinococcus multilocularis neuropeptide receptor A26 0.2985 0.428 0.4274
Echinococcus granulosus hypothetical protein 0.0283 0.0303 0.0294
Schistosoma mansoni biogenic amine receptor 0.0283 0.0303 0.0845
Echinococcus granulosus Tubulin beta 2C chain 0.011 0.0048 0.0038
Echinococcus multilocularis g protein coupled receptor 0.0283 0.0303 0.0294
Entamoeba histolytica protein kinase rad3, putative 0.0314 0.0349 0.4486
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0575 0.0733 0.1936
Giardia lamblia Heat shock protein HSP 90-alpha 0.0126 0.0073 0.0358
Trichomonas vaginalis proprotein convertase subtilisin/kexin type, putative 0.0185 0.0159 0.1761
Loa Loa (eye worm) hypothetical protein 0.0182 0.0155 0.043
Brugia malayi putative neuropeptide receptor 0.0283 0.0303 0.0841
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0283 0.0303 0.0841
Loa Loa (eye worm) hypothetical protein 0.0283 0.0303 0.0841
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0516 0.0647 0.1779
Plasmodium vivax SWIB/MDM2 domain-containing protein, putative 0.0119 0.0062 0.1319
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0329 0.037 0.1057
Loa Loa (eye worm) SWIB/MDM2 domain-containing protein 0.0119 0.0062 0.0173
Echinococcus multilocularis rhodopsin orphan GPCR 0.0283 0.0303 0.0294
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0211 0.0198 0.0445
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0283 0.0303 0.0294
Echinococcus granulosus neuropeptides capa receptor 0.0283 0.0303 0.0294
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0575 0.0733 1
Trypanosoma brucei calpain-like protein, putative 0.0113 0.0054 0.0077
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0169 0.0136 0.0126
Schistosoma mansoni biogenic amine (5HT) receptor 0.0283 0.0303 0.0845
Loa Loa (eye worm) hypothetical protein 0.0283 0.0303 0.0841
Trichomonas vaginalis tubulin beta chain, putative 0.011 0.0048 0.0176
Trypanosoma brucei hypothetical protein 0.0113 0.0054 0.0077
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.022 0.0211 0.0201
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0555 0.0704 0.1855
Brugia malayi Dopamine receptor 0.0283 0.0303 0.0841
Loa Loa (eye worm) TOPoisomerase family member 0.0182 0.0155 0.0429
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0575 0.0733 0.0723
Schistosoma mansoni protein kinase 0.0142 0.0096 0.0189
Echinococcus granulosus MAP kinase activated protein kinase 2 0.019 0.0167 0.0157
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0283 0.0303 0.0845
Brugia malayi neuropeptide F receptor 0.0283 0.0303 0.0841
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0283 0.0303 0.0294
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.0132 0.1374
Loa Loa (eye worm) BEN-1 protein 0.011 0.0048 0.0134
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0283 0.0303 0.0845
Loa Loa (eye worm) latrophilin receptor protein 2 0.0623 0.0803 0.2226
Echinococcus multilocularis SWI:SNF matrix associated 0.0119 0.0062 0.0052
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0692 0.0905 0.2747
Leishmania major phosphatidylinositol 3-kinase, putative 0.0169 0.0136 0.0248
Schistosoma mansoni brg-1 associated factor 0.0119 0.0062 0.0083
Entamoeba histolytica hypothetical protein 0.0451 0.0551 0.7391
Schistosoma mansoni hypothetical protein 0.0623 0.0803 0.2426
Chlamydia trachomatis DNA gyrase subunit B 0.0112 0.0051 0.6404
Schistosoma mansoni hypothetical protein 0.022 0.0211 0.0552
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0117 0.0059 0.0049
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0101 0.0036 0.01
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0136 0.0087 0.056
Schistosoma mansoni DNA topoisomerase II 0.0182 0.0155 0.0375
Loa Loa (eye worm) hypothetical protein 0.0867 0.1163 0.3224
Schistosoma mansoni alpha-1 adrenergic receptor 0.0283 0.0303 0.0845
Echinococcus granulosus endoplasmin 0.0126 0.0073 0.0063
Onchocerca volvulus 0.0283 0.0303 0.267
Onchocerca volvulus 0.0283 0.0303 0.267
Onchocerca volvulus Adenylate cyclase type 3 homolog 0.0165 0.013 0.1145
Chlamydia trachomatis SWIB complex protein 0.0119 0.0062 0.8044
Echinococcus granulosus rhodopsin orphan GPCR 0.0283 0.0303 0.0294
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.0182 0.0155 0.0429
Trichomonas vaginalis conserved hypothetical protein 0.0231 0.0226 0.2732
Schistosoma mansoni neuropeptide F-like receptor 0.0283 0.0303 0.0845
Loa Loa (eye worm) hypothetical protein 0.0283 0.0303 0.0841
Trichomonas vaginalis PIKK family atypical protein kinase 0.0117 0.0059 0.0332
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0113 0.0054 0.0077
Loa Loa (eye worm) hypothetical protein 0.0283 0.0303 0.0841
Loa Loa (eye worm) hypothetical protein 0.0283 0.0303 0.0841
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0283 0.0303 0.0841
Schistosoma mansoni serine-type protease inhibitor 0.225 0.3198 1
Loa Loa (eye worm) hypothetical protein 0.0185 0.0159 0.044
Echinococcus multilocularis Furin 1 0.0226 0.0219 0.0209
Entamoeba histolytica tubulin family protein 0.011 0.0048 0.0176
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0231 0.0226 0.0216
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0226 0.0219 0.2624
Onchocerca volvulus 0.0283 0.0303 0.267
Loa Loa (eye worm) phosphatidylinositol 3 0.0117 0.0059 0.0164
Schistosoma mansoni neuropeptide receptor 0.0283 0.0303 0.0845
Trichomonas vaginalis conserved hypothetical protein 0.0185 0.0159 0.1761
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0126 0.0073 0.0069
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0114 0.0054 0.0044
Loa Loa (eye worm) hypothetical protein 0.0283 0.0303 0.0841
Schistosoma mansoni opsin-like receptor 0.0283 0.0303 0.0845
Brugia malayi follicle stimulating hormone receptor 0.0283 0.0303 0.0841
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0169 0.0136 0.1433
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0283 0.0303 0.0845
Echinococcus multilocularis G protein coupled receptor 139 0.0283 0.0303 0.0294
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0329 0.037 0.0958
Echinococcus granulosus Furin 1 0.0226 0.0219 0.0209
Loa Loa (eye worm) hypothetical protein 0.2528 0.3608 1
Trichomonas vaginalis tubulin alpha chain, putative 0.011 0.0048 0.0176
Echinococcus granulosus g protein coupled receptor 0.0283 0.0303 0.0294
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0142 0.0096 0.0086
Brugia malayi larval opioid receptor 0.0283 0.0303 0.0841
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0113 0.0054 0.0077
Loa Loa (eye worm) hypothetical protein 0.0283 0.0303 0.0841
Schistosoma mansoni protein kinase 0.0142 0.0096 0.0189
Schistosoma mansoni amine GPCR 0.0283 0.0303 0.0845
Echinococcus granulosus alpha 1A adrenergic receptor 0.0283 0.0303 0.0294
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0234 0.0232 0.0545
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.0132 0.1374
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0113 0.0054 0.0077
Onchocerca volvulus 0.0117 0.0059 0.0521
Schistosoma mansoni protein kinase 0.0142 0.0096 0.0189
Echinococcus multilocularis MAP kinase activated protein kinase 2 0.019 0.0167 0.0157
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0283 0.0303 0.0845
Schistosoma mansoni amine GPCR 0.0283 0.0303 0.0845
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0417 0.05 0.6658
Trypanosoma brucei heat shock protein, putative 0.0148 0.0105 0.083
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0575 0.0733 1
Schistosoma mansoni serine-type protease inhibitor 0.225 0.3198 1
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0555 0.0704 0.9582
Trichomonas vaginalis conserved hypothetical protein 0.0197 0.0176 0.2012
Plasmodium vivax hypothetical protein, conserved 0.0119 0.0062 0.1319
Loa Loa (eye worm) hypothetical protein 0.0283 0.0303 0.0841
Leishmania major heat shock protein 83-1 0.0148 0.0105 0.0161
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0283 0.0303 0.0845
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0283 0.0303 0.0841
Onchocerca volvulus 0.0283 0.0303 0.267
Echinococcus granulosus Tubulin beta 2C chain 0.011 0.0048 0.0038
Brugia malayi Latrophilin receptor protein 2 0.0623 0.0803 0.2226
Trypanosoma brucei calpain, putative 0.0113 0.0054 0.0077
Echinococcus multilocularis SWI:SNF matrix associated 0.0119 0.0062 0.0052
Schistosoma mansoni apoptosis regulator bax 0.022 0.0211 0.0552
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0234 0.0232 0.2807
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0117 0.0059 0.0332
Brugia malayi hypothetical protein 0.0493 0.0613 0.1699
Brugia malayi heat shock protein 90 0.0148 0.0105 0.0291
Loa Loa (eye worm) tubulin beta-1 chain 0.011 0.0048 0.0134
Echinococcus granulosus neuropeptide receptor 0.0283 0.0303 0.0294
Echinococcus multilocularis rhodopsin orphan GPCR 0.0283 0.0303 0.0294
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0113 0.0054 0.0015
Echinococcus granulosus heat shock protein 90 0.0126 0.0073 0.0063
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0595 0.0763 0.0754
Loa Loa (eye worm) apoptosis regulator protein 0.022 0.0211 0.0584
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0283 0.0303 0.0845
Echinococcus multilocularis Tubulin beta 2C chain 0.011 0.0048 0.0038
Loa Loa (eye worm) hypothetical protein 0.0283 0.0303 0.0841
Plasmodium vivax hypothetical protein, conserved 0.0117 0.0059 0.1025
Loa Loa (eye worm) heat shock protein 90 0.0148 0.0105 0.0291
Echinococcus multilocularis neuropeptide s receptor 0.2985 0.428 0.4274
Schistosoma mansoni tubulin subunit beta 0.011 0.0048 0.0039
Onchocerca volvulus 0.0117 0.0059 0.0521
Brugia malayi Dopamine receptor protein 2 0.0283 0.0303 0.0841
Trichomonas vaginalis conserved hypothetical protein 0.0185 0.0159 0.1761
Loa Loa (eye worm) tubulin beta-2A chain 0.011 0.0048 0.0134
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.022 0.0211 0.0201
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0113 0.0054 0.0077
Trichomonas vaginalis conserved hypothetical protein 0.0185 0.0159 0.1761
Echinococcus multilocularis g protein coupled receptor 0.0283 0.0303 0.0294
Trichomonas vaginalis PIKK family atypical protein kinase 0.0575 0.0733 1
Echinococcus multilocularis serine protein kinase ATM 0.0329 0.037 0.0361
Echinococcus multilocularis jun protein 0.0094 0.0025 0.0015
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0692 0.0905 0.0895
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0362 0.0419 0.1102
Echinococcus granulosus neuropeptide FF receptor 2 0.0509 0.0636 0.0626
Echinococcus granulosus serine protein kinase ATM 0.0329 0.037 0.0361
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0283 0.0303 0.0294
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0169 0.0136 0.8233
Loa Loa (eye worm) hypothetical protein 0.033 0.0372 0.1031
Trichomonas vaginalis PIKK family atypical protein kinase 0.0565 0.0719 0.9803
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0113 0.0054 0.0015
Echinococcus multilocularis GPCR, family 2 0.0623 0.0803 0.0794
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0113 0.0054 0.0077
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0565 0.0719 0.98
Echinococcus granulosus tm gpcr rhodopsin 0.0283 0.0303 0.0294
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0283 0.0303 0.0294
Echinococcus granulosus somatostatin receptor 0.0283 0.0303 0.0294
Leishmania major heat shock protein 83-1 0.0148 0.0105 0.0161
Trichomonas vaginalis glucosylceramidase, putative 0.0254 0.026 0.3216
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0123 0.0069 0.019
Echinococcus multilocularis rhodopsin orphan GPCR 0.0283 0.0303 0.0294
Loa Loa (eye worm) tubulin beta chain 0.011 0.0048 0.0134
Schistosoma mansoni hypothetical protein 0.0623 0.0803 0.2426
Echinococcus multilocularis neuropeptides capa receptor 0.0283 0.0303 0.0294
Echinococcus multilocularis rhodopsin orphan GPCR 0.0283 0.0303 0.0294
Onchocerca volvulus Glucosylceramidase homolog 0.0166 0.0132 0.116
Mycobacterium ulcerans heat shock protein 90 0.0126 0.0073 1
Schistosoma mansoni hypothetical protein 0.1273 0.176 0.5453
Plasmodium falciparum DNA topoisomerase 2 0.0182 0.0155 1
Brugia malayi Protein kinase domain containing protein 0.0101 0.0036 0.01
Brugia malayi neuropeptide F receptor 0.0283 0.0303 0.0841
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0357 0.0412 0.5321
Toxoplasma gondii target of rapamycin (TOR), putative 0.0563 0.0715 0.4352
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0565 0.0719 0.1897
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0283 0.0303 0.0841
Loa Loa (eye worm) brahma associated protein 0.0119 0.0062 0.0173
Echinococcus granulosus 3-phosphoinositide-dependent protein kinase 1 0.0101 0.0036 0.0026
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0362 0.0419 0.1162
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0169 0.0136 0.1433
Echinococcus multilocularis g protein coupled receptor 0.0283 0.0303 0.0294
Echinococcus granulosus SWI:SNF matrix associated 0.0119 0.0062 0.0052
Onchocerca volvulus 0.0283 0.0303 0.267
Trichomonas vaginalis conserved hypothetical protein 0.0185 0.0159 0.1761
Trypanosoma brucei heat shock protein, putative 0.0148 0.0105 0.083
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.0127 0.0074 0.0652
Loa Loa (eye worm) endoprotease bli-4 0.0867 0.1163 0.3224
Trypanosoma brucei heat shock protein, putative 0.0148 0.0105 0.083
Giardia lamblia Hypothetical protein 0.0117 0.0059 0.0159
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0575 0.0733 0.2031
Trichomonas vaginalis conserved hypothetical protein 0.0185 0.0159 0.1761
Leishmania major heat shock protein 83-1 0.0148 0.0105 0.0161
Echinococcus granulosus GPCR family 2 0.0623 0.0803 0.0794
Leishmania major C-8 sterol isomerase-like protein 0.0362 0.0419 0.1049
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0595 0.0763 0.2126
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0516 0.0647 0.8765
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0175 0.0145 0.0402
Echinococcus multilocularis serotonin receptor 0.0283 0.0303 0.0294
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0283 0.0303 0.0845
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0117 0.0059 0.0073
Loa Loa (eye worm) phosphatidylinositol 3 0.0117 0.0059 0.0164
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0231 0.0226 0.0216
Schistosoma mansoni hypothetical protein 0.0119 0.0062 0.0083
Echinococcus granulosus heat shock protein 0.0148 0.0105 0.0095
Loa Loa (eye worm) hypothetical protein 0.0283 0.0303 0.0841
Echinococcus multilocularis neuropeptide FF receptor 2 0.0509 0.0636 0.0626
Loa Loa (eye worm) hypothetical protein 0.0509 0.0636 0.1763
Echinococcus multilocularis Tubulin beta 2C chain 0.011 0.0048 0.0038
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.0145 0.1563
Trypanosoma cruzi heat shock protein 85, putative 0.0148 0.0105 0.0169
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0595 0.0763 0.2126
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0283 0.0303 0.0841
Schistosoma mansoni histamine h1 receptor 0.0283 0.0303 0.0845
Echinococcus granulosus g-protein coupled receptor 0.0283 0.0303 0.0294
Onchocerca volvulus 0.0283 0.0303 0.267
Loa Loa (eye worm) hypothetical protein 0.0283 0.0303 0.0841
Echinococcus granulosus fmrfamide receptor 0.0283 0.0303 0.0294
Onchocerca volvulus 0.0283 0.0303 0.267
Leishmania major calcium channel protein, putative,ion transporter, putative 0.0205 0.0189 0.0398
Trichomonas vaginalis conserved hypothetical protein 0.0185 0.0159 0.1761
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0112 0.0051 0.0311
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0575 0.0733 0.1936
Trypanosoma cruzi heat shock protein 85, putative 0.0148 0.0105 0.0169
Loa Loa (eye worm) hypothetical protein 0.0283 0.0303 0.0841
Echinococcus granulosus tubulin beta 1 chain 0.011 0.0048 0.0038
Loa Loa (eye worm) hypothetical protein 0.0283 0.0303 0.0841
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0117 0.0059 0.036
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0117 0.0059 0.0159
Echinococcus granulosus nmda type glutamate receptor 0.0114 0.0054 0.0044
Toxoplasma gondii SWIB/MDM2 domain-containing protein 0.0119 0.0062 0.0379
Schistosoma mansoni biogenic amine (5HT) receptor 0.0283 0.0303 0.0845
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0169 0.0136 0.0316
Loa Loa (eye worm) hypothetical protein 0.0314 0.0349 0.0966
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0283 0.0303 0.0841
Onchocerca volvulus 0.0283 0.0303 0.267
Leishmania major hypothetical protein, unknown function 0.0117 0.0059 0.0031
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0117 0.0059 0.1025
Echinococcus multilocularis allatostatin A receptor 0.0849 0.1137 0.1127
Echinococcus granulosus furin 0.0867 0.1163 0.1154
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0329 0.037 0.1027
Leishmania major heat shock protein 83-1 0.0148 0.0105 0.0161
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0226 0.0219 0.2624
Loa Loa (eye worm) G-protein coupled receptor 0.0283 0.0303 0.0841
Loa Loa (eye worm) hypothetical protein 0.0334 0.0378 0.1049
Loa Loa (eye worm) hypothetical protein 0.0362 0.0419 0.1162
Trichomonas vaginalis leucine-rich repeat protein, BspA family 0.0185 0.0159 0.1761
Schistosoma mansoni hypothetical protein 0.022 0.0211 0.0552
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0234 0.0232 0.2807
Loa Loa (eye worm) hypothetical protein 0.0283 0.0303 0.0841
Echinococcus granulosus neuropeptide receptor 0.0283 0.0303 0.0294
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0849 0.1137 0.348
Loa Loa (eye worm) hypothetical protein 0.0849 0.1137 0.315
Loa Loa (eye worm) beta-tubulin 0.011 0.0048 0.0134
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0575 0.0733 1
Trichomonas vaginalis DNA topoisomerase II, putative 0.0182 0.0155 0.1703
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0117 0.0059 0.0159
Trichomonas vaginalis PIKK family atypical protein kinase 0.0544 0.0688 0.9359
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0314 0.0349 0.0339
Leishmania major DNA topoisomerase ii 0.0173 0.0141 0.0263
Trichomonas vaginalis PIKK family atypical protein kinase 0.0563 0.0715 0.9753
Loa Loa (eye worm) hypothetical protein 0.0283 0.0303 0.0841
Echinococcus granulosus dro:myosuppressin receptor 0.0283 0.0303 0.0294
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0575 0.0733 0.2035
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0169 0.0136 0.026
Schistosoma mansoni tubulin subunit beta 0.011 0.0048 0.0039
Plasmodium falciparum DNA gyrase subunit B 0.0112 0.0051 0.0263
Leishmania major hypothetical protein, conserved 0.2512 0.3583 1
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0117 0.0059 0.1025
Leishmania major phosphatidylinositol kinase related protein, putative 0.0132 0.0081 0.0093
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0234 0.0232 0.2807
Echinococcus multilocularis heat shock protein 90 0.0148 0.0105 0.0095
Loa Loa (eye worm) TYRA-2 protein 0.0283 0.0303 0.0841
Treponema pallidum DNA gyrase, subunit B (gyrB) 0.0112 0.0051 0.6692
Toxoplasma gondii beta-1 tubulin, putative 0.011 0.0048 0.0294
Toxoplasma gondii PAN domain-containing protein 0.1194 0.1644 1
Echinococcus multilocularis SWI:SNF matrix associated 0.0119 0.0062 0.0052
Plasmodium vivax heat shock protein 86, putative 0.0148 0.0105 0.5342
Loa Loa (eye worm) hypothetical protein 0.0283 0.0303 0.0841
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0203 0.0185 0.0407
Plasmodium vivax hypothetical protein 0.0117 0.0059 0.1025
Trichomonas vaginalis glucosylceramidase, putative 0.0254 0.026 0.3216
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0314 0.0349 0.0893
Brugia malayi hypothetical protein 0.0283 0.0303 0.0841
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0516 0.0647 0.8765
Echinococcus multilocularis sex peptide receptor 0.0283 0.0303 0.0294
Schistosoma mansoni heat shock protein 0.0148 0.0105 0.0218
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0516 0.0647 0.1779
Loa Loa (eye worm) hypothetical protein 0.0283 0.0303 0.0841
Trypanosoma cruzi target of rapamycin kinase 3 0.0565 0.0719 0.1994
Trichomonas vaginalis PIKK family atypical protein kinase 0.0369 0.043 0.5649
Loa Loa (eye worm) phosphatidylinositol 3 0.0117 0.0059 0.0164
Echinococcus multilocularis epidermal growth factor receptor 0.0135 0.0086 0.0076
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0283 0.0303 0.0845
Loa Loa (eye worm) hypothetical protein 0.0283 0.0303 0.0841
Trichomonas vaginalis PIKK family atypical protein kinase 0.0563 0.0715 0.9753
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0117 0.0059 0.036
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0329 0.037 0.4707
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0169 0.0136 0.1433
Leishmania major phosphatidylinositol kinase, putative 0.0117 0.0059 0.0031
Schistosoma mansoni hypothetical protein 0.022 0.0211 0.0552
Echinococcus multilocularis Zinc finger, PHD finger 0.0169 0.0136 0.0126
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.0132 0.1374
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0254 0.026 0.0721
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0126 0.0073 1
Loa Loa (eye worm) neuropeptide F receptor 0.0283 0.0303 0.0841
Trichomonas vaginalis heat shock protein, putative 0.0148 0.0105 0.0991
Schistosoma mansoni endoplasmin 0.0148 0.0105 0.0218
Schistosoma mansoni neuropeptide receptor 0.0283 0.0303 0.0845
Echinococcus granulosus tubulin subunit beta 0.011 0.0048 0.0038
Loa Loa (eye worm) hypothetical protein 0.0283 0.0303 0.0841
Brugia malayi proprotein convertase 2 0.0555 0.0704 0.1951
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0538 0.0678 0.9219
Entamoeba histolytica hypothetical protein 0.0117 0.0059 0.0332
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0234 0.0232 0.2678
Brugia malayi ORL1-like opioid receptor 0.0283 0.0303 0.0841
Onchocerca volvulus 0.0283 0.0303 0.267
Loa Loa (eye worm) adenylyl cyclase 3 0.0141 0.0094 0.0261
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0142 0.0096 0.0086
Loa Loa (eye worm) hypothetical protein 0.0283 0.0303 0.0841
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0169 0.0136 0.0126
Trypanosoma cruzi Heat shock protein 83, putative 0.0148 0.0105 0.0169
Trichomonas vaginalis conserved hypothetical protein 0.0185 0.0159 0.1761
Brugia malayi FAT domain containing protein 0.0231 0.0226 0.0627
Echinococcus granulosus tubulin beta 4A class IVa 0.011 0.0048 0.0038
Loa Loa (eye worm) hypothetical protein 0.0283 0.0303 0.0841
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0126 0.0073 1
Echinococcus multilocularis fmrfamide receptor 0.0283 0.0303 0.0294
Schistosoma mansoni biogenic amine receptor 0.0283 0.0303 0.0845
Giardia lamblia Heat shock protein HSP 90-alpha 0.0148 0.0105 0.083
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0451 0.0551 0.7391
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0117 0.0059 0.1025
Brugia malayi hypothetical protein 0.0283 0.0303 0.0841
Schistosoma mansoni tubulin subunit beta 0.011 0.0048 0.0039
Echinococcus granulosus Tubulin beta 2C chain 0.011 0.0048 0.0038
Loa Loa (eye worm) tubulin beta-4 chain 0.011 0.0048 0.0134
Schistosoma mansoni neuropeptide receptor 0.0283 0.0303 0.0845
Echinococcus multilocularis 0.0683 0.0891 0.0882
Trypanosoma brucei heat shock protein, putative 0.0148 0.0105 0.083
Brugia malayi G-protein coupled receptor 0.0283 0.0303 0.0841
Onchocerca volvulus 0.0119 0.0062 0.0549
Echinococcus granulosus G protein coupled receptor 139 0.0283 0.0303 0.0294
Brugia malayi hypothetical protein 0.0283 0.0303 0.0841
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0575 0.0733 0.0723
Trypanosoma cruzi DNA topoisomerase II, putative 0.0173 0.0141 0.0276
Schistosoma mansoni hypothetical protein 0.0283 0.0303 0.0845
Echinococcus multilocularis G-protein coupled receptor, putative 0.0283 0.0303 0.0294
Leishmania major heat shock protein 83-1 0.0148 0.0105 0.0161
Echinococcus granulosus neuroendocrine convertase 2 0.0555 0.0704 0.0694
Leishmania major heat shock protein 83-1 0.0148 0.0105 0.0161
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0254 0.026 0.0721
Brugia malayi Transforming growth factor beta like domain containing protein 0.0125 0.0071 0.0198
Brugia malayi hypothetical protein 0.0283 0.0303 0.0841
Echinococcus granulosus Tubulin beta 2C chain 0.011 0.0048 0.0038
Leishmania major heat shock protein 83-1 0.0148 0.0105 0.0161
Loa Loa (eye worm) hypothetical protein 0.0283 0.0303 0.0841
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0117 0.0059 0.1025
Trichomonas vaginalis PIKK family atypical protein kinase 0.0563 0.0715 0.9753
Brugia malayi hypothetical protein 0.0283 0.0303 0.0841
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0169 0.0136 0.0248
Brugia malayi GnHR receptor homolog 0.0283 0.0303 0.0841
Toxoplasma gondii subtilisin SUB12 0.0118 0.006 0.0365
Giardia lamblia Grp94/Hsp90 0.0126 0.0073 0.0358
Echinococcus granulosus serotonin receptor 0.0283 0.0303 0.0294
Loa Loa (eye worm) phosphatidylinositol kinase 0.0117 0.0059 0.0164
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0334 0.0378 0.0369
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0283 0.0303 0.0294
Echinococcus granulosus epidermal growth factor receptor 0.0135 0.0086 0.0076
Chlamydia trachomatis DNA topoisomerase I 0.0128 0.0076 1
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0595 0.0763 0.23
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0399 0.0474 0.6291
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.2755 0.3941 0.3935
Trypanosoma cruzi heat shock protein 85, putative 0.0126 0.0073 0.0073
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0169 0.0136 0.1433
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0283 0.0303 0.0845
Loa Loa (eye worm) hypothetical protein 0.0114 0.0055 0.0152
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0117 0.0059 0.0073
Trichomonas vaginalis PIKK family atypical protein kinase 0.0554 0.0702 0.9555
Schistosoma mansoni hypothetical protein 0.0623 0.0803 0.2426
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0283 0.0303 0.0845
Brugia malayi Probable DNA topoisomerase II 0.0182 0.0155 0.0429
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0544 0.0688 0.9347
Loa Loa (eye worm) hypothetical protein 0.0114 0.0055 0.0152
Treponema pallidum heat shock protein 90 0.0126 0.0073 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0283 0.0303 0.0294
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0334 0.0378 0.1049
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0117 0.0059 0.0033
Loa Loa (eye worm) hypothetical protein 0.0283 0.0303 0.0841
Trichomonas vaginalis PIKK family atypical protein kinase 0.0556 0.0705 0.9606
Onchocerca volvulus 0.0283 0.0303 0.267
Trichomonas vaginalis glucosylceramidase, putative 0.0254 0.026 0.3216
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0283 0.0303 0.0294
Echinococcus granulosus peptide allatostatin:somatostatin 0.0283 0.0303 0.0294
Brugia malayi Tachykinin-like peptides receptor 99D 0.0509 0.0636 0.1763
Trichomonas vaginalis PIKK family atypical protein kinase 0.0554 0.0702 0.9556
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase 0.019 0.0167 0.0462
Echinococcus granulosus anti dorsalizing morphogenetic protein 1a 0.0125 0.0071 0.0061
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0867 0.1163 0.3565
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0623 0.0803 0.2226
Trichomonas vaginalis PIKK family atypical protein kinase 0.0117 0.0059 0.0332
Trichomonas vaginalis tubulin, putative 0.011 0.0048 0.0176
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0283 0.0303 0.0845
Schistosoma mansoni heat shock protein 0.0148 0.0105 0.0218
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0117 0.0059 0.0032
Trichomonas vaginalis neuroendocrine convertase 2 precursor, putative 0.0185 0.0159 0.1761
Giardia lamblia High cysteine membrane protein Group 2 0.0312 0.0346 0.4354
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase subunit type II alpha 0.0123 0.0069 0.019
Schistosoma mansoni adenoreceptor 0.0283 0.0303 0.0845
Trichomonas vaginalis heat shock protein, putative 0.0126 0.0073 0.0527
Plasmodium vivax DNA gyrase subunit B, putative 0.0112 0.0051 0.0263
Loa Loa (eye worm) hypothetical protein 0.0211 0.0198 0.0549
Loa Loa (eye worm) TK/EGFR protein kinase 0.0135 0.0086 0.0238
Schistosoma mansoni neuropeptide receptor 0.0283 0.0303 0.0845
Brugia malayi Furin-like cysteine rich region family protein 0.0135 0.0086 0.0238
Trichomonas vaginalis PIKK family atypical protein kinase 0.0555 0.0704 0.9589
Echinococcus multilocularis beta tubulin 0.011 0.0048 0.0038
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.0119 0.0062 0.1319
Trypanosoma brucei DNA topoisomerase II beta, putative 0.0173 0.0141 0.1358
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0113 0.0054 0.0016
Mycobacterium tuberculosis DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0112 0.0051 0.6692
Leishmania major heat shock protein 83-1 0.0148 0.0105 0.0161
Onchocerca volvulus 0.0283 0.0303 0.267
Loa Loa (eye worm) neuropeptide F receptor 0.0283 0.0303 0.0841
Toxoplasma gondii heat shock protein HSP90 0.0148 0.0105 0.064
Onchocerca volvulus 0.0283 0.0303 0.267
Trichomonas vaginalis PIKK family atypical protein kinase 0.0565 0.0719 0.9803
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.0132 0.1374
Echinococcus multilocularis nmda type glutamate receptor 0.0114 0.0054 0.0044
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0117 0.0059 0.0164
Loa Loa (eye worm) hypothetical protein 0.0623 0.0803 0.2226
Toxoplasma gondii DNA topoisomerase domain-containing protein 0.0119 0.0062 0.0379
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0269 0.0283 0.354
Echinococcus multilocularis rhodopsin orphan GPCR 0.0283 0.0303 0.0294
Onchocerca volvulus 0.0319 0.0357 0.3141
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.022 0.0211 0.0552
Brugia malayi latrophilin 2 splice variant baaae 0.1273 0.176 0.4879
Chlamydia trachomatis DNA gyrase subunit B 0.0091 0.0021 0.1966
Echinococcus multilocularis dro:myosuppressin receptor 0.0283 0.0303 0.0294
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.0132 0.1374
Plasmodium vivax endoplasmin, putative 0.0148 0.0105 0.5342
Brugia malayi Serotonin receptor 0.0283 0.0303 0.0841
Entamoeba histolytica hypothetical protein 0.0329 0.037 0.48
Trichomonas vaginalis conserved hypothetical protein 0.0185 0.0159 0.1761
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0117 0.0059 0.0164
Trichomonas vaginalis PIKK family atypical protein kinase 0.0563 0.0715 0.9753
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.0132 0.1374
Brugia malayi Calcitonin receptor-like protein seb-1 0.1896 0.2677 0.7419
Trichomonas vaginalis PIKK family atypical protein kinase 0.0325 0.0365 0.4716
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0182 0.0155 0.1558
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0417 0.05 0.6658
Loa Loa (eye worm) hypothetical protein 0.0283 0.0303 0.0841
Loa Loa (eye worm) hypothetical protein 0.0283 0.0303 0.0841
Loa Loa (eye worm) phosphatidylinositol 3 0.0117 0.0059 0.0164
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0113 0.0054 0.0016
Echinococcus granulosus 7TM GPCR rhodopsin 0.0283 0.0303 0.0294
Brugia malayi hypothetical protein 0.0283 0.0303 0.0841
Schistosoma mansoni biogenic amine receptor 0.0283 0.0303 0.0845
Trypanosoma brucei heat shock protein, putative 0.0148 0.0105 0.083
Echinococcus granulosus beta tubulin 0.011 0.0048 0.0038
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0283 0.0303 0.0845
Brugia malayi RE15519p 0.0283 0.0303 0.0841
Trichomonas vaginalis glucosylceramidase, putative 0.0254 0.026 0.3216
Trichomonas vaginalis PIKK family atypical protein kinase 0.0563 0.0715 0.9753
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0132 0.0081 0.0098
Loa Loa (eye worm) hypothetical protein 0.0283 0.0303 0.0841
Loa Loa (eye worm) hypothetical protein 0.1273 0.176 0.4879
Entamoeba histolytica hypothetical protein 0.0117 0.0059 0.0332
Trichomonas vaginalis conserved hypothetical protein 0.0185 0.0159 0.1761
Trichomonas vaginalis tubulin epsilon chain, putative 0.011 0.0048 0.0176
Echinococcus multilocularis serotonin receptor 0.0283 0.0303 0.0294
Giardia lamblia DNA topoisomerase II 0.016 0.0122 0.1082
Echinococcus multilocularis Tubulin beta 2C chain 0.011 0.0048 0.0038
Trypanosoma brucei Heat shock protein 83, putative 0.0148 0.0105 0.083
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.2528 0.3608 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0283 0.0303 0.0294
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0117 0.0059 0.0049
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0516 0.0647 0.1792
Trichomonas vaginalis PIKK family atypical protein kinase 0.0332 0.0376 0.488
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0516 0.0647 0.8765
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0283 0.0303 0.0294
Loa Loa (eye worm) hypothetical protein 0.0319 0.0357 0.0989
Toxoplasma gondii heat shock protein 90, putative 0.0148 0.0105 0.064
Loa Loa (eye worm) hypothetical protein 0.0283 0.0303 0.0841
Trichomonas vaginalis PIKK family atypical protein kinase 0.0565 0.0719 0.9803
Mycobacterium tuberculosis Conserved hypothetical protein 0.0117 0.0059 0.7928
Loa Loa (eye worm) hypothetical protein 0.0283 0.0303 0.0841
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0234 0.0232 0.0642
Schistosoma mansoni fkbp-rapamycin associated protein 0.0314 0.0349 0.0988
Trichomonas vaginalis PIKK family atypical protein kinase 0.0575 0.0733 1
Giardia lamblia Phosphatidylinositol 4-kinase 0.0117 0.0059 0.0159
Echinococcus multilocularis neuroendocrine convertase 2 0.0555 0.0704 0.0694
Echinococcus granulosus neuropeptide Y receptor 0.0283 0.0303 0.0294
Trypanosoma brucei heat shock protein, putative 0.0148 0.0105 0.083
Schistosoma mansoni opsin-like receptor 0.0283 0.0303 0.0845
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0226 0.0219 0.2624
Trichomonas vaginalis PIKK family atypical protein kinase 0.0554 0.0702 0.9556
Loa Loa (eye worm) hypothetical protein 0.0283 0.0303 0.0841
Schistosoma mansoni hypothetical protein 0.0119 0.0062 0.0083
Echinococcus multilocularis tubulin beta 1 chain 0.011 0.0048 0.0038
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0117 0.0059 0.0164
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0283 0.0303 0.0845
Brugia malayi Tubulin beta-1 chain 0.011 0.0048 0.0134
Leishmania major heat shock protein 83-1 0.0148 0.0105 0.0161
Brugia malayi bZIP transcription factor family protein 0.0094 0.0025 0.007
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0169 0.0136 0.1433
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0283 0.0303 0.0845
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0226 0.0219 0.2624
Loa Loa (eye worm) hypothetical protein 0.0091 0.0022 0.006
Echinococcus granulosus biogenic amine 5HT receptor 0.0283 0.0303 0.0294
Trichomonas vaginalis conserved hypothetical protein 0.0348 0.0399 0.5206
Trypanosoma cruzi heat shock protein 90, putative 0.0126 0.0073 0.0073
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0283 0.0303 0.0294
Echinococcus granulosus neuropeptide Y receptor 0.0283 0.0303 0.0294
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0283 0.0303 0.0845
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0283 0.0303 0.0845
Leishmania major phosphatidylinositol 4-kinase, putative 0.0117 0.0059 0.0031
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0325 0.0365 0.4716
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0283 0.0303 0.0841
Echinococcus granulosus glutamate NMDA receptor subunit 0.0269 0.0283 0.0273
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0283 0.0303 0.0294
Echinococcus granulosus rhodopsin orphan GPCR 0.0283 0.0303 0.0294
Loa Loa (eye worm) hypothetical protein 0.022 0.0211 0.0584
Schistosoma mansoni hypothetical protein 0.0283 0.0303 0.0845
Echinococcus granulosus beta tubulin 0.011 0.0048 0.0038
Trichomonas vaginalis hypothetical protein 0.0185 0.0159 0.1761
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0575 0.0733 0.2203
Loa Loa (eye worm) BEN-1 protein 0.011 0.0048 0.0134
Loa Loa (eye worm) hypothetical protein 0.0348 0.0399 0.1105
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0319 0.0357 0.1015
Leishmania major heat shock protein 83-1 0.0148 0.0105 0.0161
Trichomonas vaginalis PIKK family atypical protein kinase 0.0335 0.0379 0.4929
Leishmania major heat shock protein 83-1 0.0148 0.0105 0.0161
Echinococcus multilocularis rhodopsin orphan GPCR 0.0283 0.0303 0.0294
Echinococcus granulosus neuropeptide s receptor 0.2985 0.428 0.4274
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0283 0.0303 0.0294
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0283 0.0303 0.0294
Trypanosoma brucei heat shock protein, putative 0.0148 0.0105 0.083

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) > 500 mg/kg/day Antitumor activity against mouse L1210 cells allografted in ip dosed C3H/DBA2 F1 mouse assessed as optimum dose required to increase in maximum life span administered as qd for 5 days ChEMBL. 950644
C50 (functional) = 16 uM Inhibitory concentration against ethidium binding to DNA ChEMBL. 7205885
IC50 (functional) = 0 nM Inhibitory concentration of the compound to reduce the growth of L1210 cells by 50% after 70 h; No data ChEMBL. 3820217
IC50 (functional) = 2.7 uM Concentration required to reduce the growth of human Jurkat cells to 50% of control cultures ChEMBL. 9258370
IC50 (functional) = 2.7 uM Concentration required to reduce incorporation of [3H]-TdR in drug-treated cultures of intracellular Leishmania major to 50% of controls ChEMBL. 9258370
IC50 (functional) = 2.7 uM Concentration required to reduce the growth of human Jurkat cells to 50% of control cultures ChEMBL. 9258370
IC50 (functional) = 2.7 uM Concentration required to reduce incorporation of [3H]-TdR in drug-treated cultures of intracellular Leishmania major to 50% of controls ChEMBL. 9258370
ILS (functional) NA 0 % Maximum percent increase in life span of mice ChEMBL. 7205885
ILSmax (functional) = 25 % Tumor cell selectivity determined as maximal percent increase in life span (ILSmax) at LD10 dosage level in L1210 cells ChEMBL. 7120279
ILSmax (functional) = 25 % Tumor cell selectivity determined as maximal percent increase in life span (ILSmax) at LD10 dosage level in L1210 cells ChEMBL. 7120279
Index = 0 Lipophilicity index (substitution method) ChEMBL. 9258370
LD10 (ADMET) = 200 mg kg-1 Drug dose that is lethal to 10% of animals was measured ChEMBL. 7205885
LD10 (ADMET) = 200 mg kg-1 Drug dose that is lethal to 10% of animals was measured ChEMBL. 7205885
Log 1/D50 (functional) = 0 Dose of the drug (mol /kg) providing a 50% life extension in L1210 assays when given at qd 1-5 schedule; No data ChEMBL. 3820217
Log 1/D50 (functional) < 3.19 Drug concentration in mole/kg/day providing 50% extension of life in intraperitoneally implanted leukemia L1210 mice. ChEMBL. 7069706
Log 1/LD10 (ADMET) = 3.19 Compound concentration in mole/kg/day lethal to 10% of mice ChEMBL. 7069706
Log K (binding) = 5.85 Association constant for binding to poly [d(G-C)] ChEMBL. 7205885
Log K (binding) = 5.86 Association constant for binding to poly [d(A-T)] ChEMBL. 7205885
MTD (ADMET) = 105 mg/kg/day Toxicity in ip dosed BDF1 mouse allografted with mouse P388 cells administered qd for 5 days ChEMBL. 671464
pKa = 7.46 Ionisation constant (pKa) ChEMBL. 7205885
Therapeutic index (ADMET) = 1 In vitro therapeutic index calculated as the IC50 ratio of Jurkat cells to that of Leishmania major. ChEMBL. 9258370
Therapeutic index (ADMET) = 1 In vitro therapeutic index calculated as the IC50 ratio of Jurkat cells to that of Leishmania major. ChEMBL. 9258370

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Leishmania major ChEMBL23 9258370
Homo sapiens ChEMBL23 9258370

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

Affected Entity Phenotypic quality Occurs in Occurs at Evidence Observed in Targets
cytolysis (GO:0019835) increased (PATO:0000470) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania chagasi 22297  
Annotator: aaronjr@u.washington.edu Comment: Drug: 13365-36-1; Drug: 61421-82-7; Drug: 61421-83-8; Drug: 139501-99-8. chemical inhibition with topoisomerase inhibitors leads to lysis and reduced motility; unclear as to which topoisomerase II gene/enzyme was studied References: 1318684
cytolysis (GO:0019835) increased (PATO:0000470) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania chagasi 22658  
Annotator: aaronjr@u.washington.edu Comment: Drug: 13365-36-1; Drug: 61421-82-7; Drug: 61421-83-8; Drug: 139501-99-8. chemical inhibition with topoisomerase inhibitors leads to lysis and reduced motility; unclear as to which topoisomerase II gene/enzyme was studied References: 1318684
cytolysis (GO:0019835) increased (PATO:0000470) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania donovani 22297  
Annotator: aaronjr@u.washington.edu Comment: Drug: 13365-36-1; Drug: 61421-82-7; Drug: 61421-83-8; Drug: 139501-99-8. chemical inhibition with topoisomerase inhibitors leads to lysis and reduced motility; unclear as to which topoisomerase II gene/enzyme was studied References: 1318684
cytolysis (GO:0019835) increased (PATO:0000470) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania donovani 22658  
Annotator: aaronjr@u.washington.edu Comment: Drug: 13365-36-1; Drug: 61421-82-7; Drug: 61421-83-8; Drug: 139501-99-8. chemical inhibition with topoisomerase inhibitors leads to lysis and reduced motility; unclear as to which topoisomerase II gene/enzyme was studied References: 1318684
cell motility (GO:0006928) decreased (PATO:0000468) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania chagasi 22297  
Annotator: aaronjr@u.washington.edu Comment: Drug: 13365-36-1; Drug: 61421-82-7; Drug: 61421-83-8; Drug: 139501-99-8. chemical inhibition with topoisomerase inhibitors leads to lysis and reduced motility; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 1318684
cell motility (GO:0006928) decreased (PATO:0000468) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania chagasi 22658  
Annotator: aaronjr@u.washington.edu Comment: Drug: 13365-36-1; Drug: 61421-82-7; Drug: 61421-83-8; Drug: 139501-99-8. chemical inhibition with topoisomerase inhibitors leads to lysis and reduced motility; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 1318684
cell motility (GO:0006928) decreased (PATO:0000468) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania donovani 22297  
Annotator: aaronjr@u.washington.edu Comment: Drug: 13365-36-1; Drug: 61421-82-7; Drug: 61421-83-8; Drug: 139501-99-8. chemical inhibition with topoisomerase inhibitors leads to lysis and reduced motility; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 1318684
cell motility (GO:0006928) decreased (PATO:0000468) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania donovani 22658  
Annotator: aaronjr@u.washington.edu Comment: Drug: 13365-36-1; Drug: 61421-82-7; Drug: 61421-83-8; Drug: 139501-99-8. chemical inhibition with topoisomerase inhibitors leads to lysis and reduced motility; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 1318684
chromosomal_structural_element (SO:0000628) biosynthetic process (GO:0009058) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania chagasi 22297  
Annotator: crowther@u.washington.edu Comment: Drug: 13365-36-1; Drug: 13365-38-3; Drug: 61421-82-7; Drug: 61462-75-7; Drug: 62382-99-4; Drug: 75775-90-5; Drug: 136633-55-1. chemical inhibition with topoisomerase inhibitors leads to generation of cleavable complex and growth inhibition; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 7935616
chromosomal_structural_element (SO:0000628) biosynthetic process (GO:0009058) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania chagasi 22658  
Annotator: crowther@u.washington.edu Comment: Drug: 13365-36-1; Drug: 13365-38-3; Drug: 61421-82-7; Drug: 61462-75-7; Drug: 62382-99-4; Drug: 75775-90-5; Drug: 136633-55-1. chemical inhibition with topoisomerase inhibitors leads to generation of cleavable complex and growth inhibition; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 7935616
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania chagasi 22297  
Annotator: crowther@u.washington.edu Comment: Drug: 13365-36-1; Drug: 13365-38-3; Drug: 61421-82-7; Drug: 61462-75-7; Drug: 62382-99-4; Drug: 75775-90-5; Drug: 136633-55-1. chemical inhibition with topoisomerase inhibitors leads to generation of cleavable complex and growth inhibition; unclear as to which topoisomerase II gene/enzyme was studied References: 7935616
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania chagasi 22658  
Annotator: crowther@u.washington.edu Comment: Drug: 13365-36-1; Drug: 13365-38-3; Drug: 61421-82-7; Drug: 61462-75-7; Drug: 62382-99-4; Drug: 75775-90-5; Drug: 136633-55-1. chemical inhibition with topoisomerase inhibitors leads to generation of cleavable complex and growth inhibition; unclear as to which topoisomerase II gene/enzyme was studied References: 7935616
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) amastigote (BTO:0000062) inferred from bioassay (ECO:0000094) Leishmania major 22297  
Annotator: crowther@u.washington.edu Comment: Drug: 143771-93-1; Drug: 148462-27-5; Drug: 148462-28-6; Drug: 157615-54-8; Drug: 192934-58-0; Drug: 192934-59-1; Drug: 192934-60-4; Drug: 192934-61-5; Drug: 192934-62-6; Drug: 192934-63-7; Drug: 192934-64-8; Drug: 192934-65-9; Drug: 192934-66-0; Drug: 192934-67-1; Drug: 192934-68-2; Drug: 192934-69-3; Drug: 192934-70-6; Drug: 192934-71-7; Drug: 192934-72-8; Drug: 192934-73-9; Drug: 192934-74-0; Drug: 192934-75-1; Drug: 192934-77-3; Drug: 192934-78-4; Drug: 192934-79-5; Drug: 13365-38-3; Drug: 58658-17-6; Drug: 75775-91-6; Drug: 75776-00-0; Drug: 76015-34-4; Drug: 110022-12-3; Drug: 110022-16-7; Drug: 110022-28-1; Drug: 123404-10-4; Drug: 129619-92-7; Drug: 147152-70-3; Drug: 155457-31-1; Drug: 155457-44-6; Drug: 155457-46-8; Drug: 192934-57-9; Drug: 192934-76-2. chemical inhibition with topoisomerase inhibitors leads to growth inhibition; unclear as to which topoisomerase II gene/enzyme was studied References: 9258370
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) amastigote (BTO:0000062) inferred from bioassay (ECO:0000094) Leishmania major 22658  
Annotator: crowther@u.washington.edu Comment: Drug: 143771-93-1; Drug: 148462-27-5; Drug: 148462-28-6; Drug: 157615-54-8; Drug: 192934-58-0; Drug: 192934-59-1; Drug: 192934-60-4; Drug: 192934-61-5; Drug: 192934-62-6; Drug: 192934-63-7; Drug: 192934-64-8; Drug: 192934-65-9; Drug: 192934-66-0; Drug: 192934-67-1; Drug: 192934-68-2; Drug: 192934-69-3; Drug: 192934-70-6; Drug: 192934-71-7; Drug: 192934-72-8; Drug: 192934-73-9; Drug: 192934-74-0; Drug: 192934-75-1; Drug: 192934-77-3; Drug: 192934-78-4; Drug: 192934-79-5; Drug: 13365-38-3; Drug: 58658-17-6; Drug: 75775-91-6; Drug: 75776-00-0; Drug: 76015-34-4; Drug: 110022-12-3; Drug: 110022-16-7; Drug: 110022-28-1; Drug: 123404-10-4; Drug: 129619-92-7; Drug: 147152-70-3; Drug: 155457-31-1; Drug: 155457-44-6; Drug: 155457-46-8; Drug: 192934-57-9; Drug: 192934-76-2. chemical inhibition with topoisomerase inhibitors leads to growth inhibition; unclear as to which topoisomerase II gene/enzyme was studied References: 9258370
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) amastigote (BTO:0000062) inferred from bioassay (ECO:0000094) Leishmania donovani 22297  
Annotator: crowther@u.washington.edu Comment: Drug: 143771-93-1; Drug: 148462-27-5; Drug: 148462-28-6; Drug: 157615-54-8; Drug: 192934-58-0; Drug: 192934-59-1; Drug: 192934-60-4; Drug: 192934-61-5; Drug: 192934-62-6; Drug: 192934-63-7; Drug: 192934-64-8; Drug: 192934-65-9; Drug: 192934-66-0; Drug: 192934-67-1; Drug: 192934-68-2; Drug: 192934-69-3; Drug: 192934-70-6; Drug: 192934-71-7; Drug: 192934-72-8; Drug: 192934-73-9; Drug: 192934-74-0; Drug: 192934-75-1; Drug: 192934-77-3; Drug: 192934-78-4; Drug: 192934-79-5; Drug: 13365-38-3; Drug: 58658-17-6; Drug: 75775-91-6; Drug: 75776-00-0; Drug: 76015-34-4; Drug: 110022-12-3; Drug: 110022-16-7; Drug: 110022-28-1; Drug: 123404-10-4; Drug: 129619-92-7; Drug: 147152-70-3; Drug: 155457-31-1; Drug: 155457-44-6; Drug: 155457-46-8; Drug: 192934-57-9; Drug: 192934-76-2. chemical inhibition with topoisomerase inhibitors leads to growth inhibition; unclear as to which topoisomerase II gene/enzyme was studied References: 9258370
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) amastigote (BTO:0000062) inferred from bioassay (ECO:0000094) Leishmania donovani 22658  
Annotator: crowther@u.washington.edu Comment: Drug: 143771-93-1; Drug: 148462-27-5; Drug: 148462-28-6; Drug: 157615-54-8; Drug: 192934-58-0; Drug: 192934-59-1; Drug: 192934-60-4; Drug: 192934-61-5; Drug: 192934-62-6; Drug: 192934-63-7; Drug: 192934-64-8; Drug: 192934-65-9; Drug: 192934-66-0; Drug: 192934-67-1; Drug: 192934-68-2; Drug: 192934-69-3; Drug: 192934-70-6; Drug: 192934-71-7; Drug: 192934-72-8; Drug: 192934-73-9; Drug: 192934-74-0; Drug: 192934-75-1; Drug: 192934-77-3; Drug: 192934-78-4; Drug: 192934-79-5; Drug: 13365-38-3; Drug: 58658-17-6; Drug: 75775-91-6; Drug: 75776-00-0; Drug: 76015-34-4; Drug: 110022-12-3; Drug: 110022-16-7; Drug: 110022-28-1; Drug: 123404-10-4; Drug: 129619-92-7; Drug: 147152-70-3; Drug: 155457-31-1; Drug: 155457-44-6; Drug: 155457-46-8; Drug: 192934-57-9; Drug: 192934-76-2. chemical inhibition with topoisomerase inhibitors leads to growth inhibition; unclear as to which topoisomerase II gene/enzyme was studied References: 9258370

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

11 literature references were collected for this gene.

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