Detailed information for compound 714404

Basic information

Technical information
  • TDR Targets ID: 714404
  • Name: N,N-diethyl-2-(4-methylpiperazin-1-yl)quinazo lin-4-amine
  • MW: 299.414 | Formula: C17H25N5
  • H donors: 0 H acceptors: 2 LogP: 3 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCN(c1nc(nc2c1cccc2)N1CCN(CC1)C)CC
  • InChi: 1S/C17H25N5/c1-4-21(5-2)16-14-8-6-7-9-15(14)18-17(19-16)22-12-10-20(3)11-13-22/h6-9H,4-5,10-13H2,1-3H3
  • InChiKey: OQJDEQRNNWINFZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N,N-diethyl-2-(4-methyl-1-piperazinyl)-4-quinazolinamine
  • diethyl-[2-(4-methylpiperazin-1-yl)quinazolin-4-yl]amine
  • BAS 12344803

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis jumonji domain containing protein 0.0041 0.0617 0.0987
Trypanosoma brucei glucose transporter 1E 0.0032 0.0438 0.2867
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0376 0.0587
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0031 0.0416 0.0472
Toxoplasma gondii Erv1 / Alr family protein 0.0034 0.0485 0.0712
Brugia malayi Bromodomain containing protein 0.0032 0.0426 0.0484
Loa Loa (eye worm) hypothetical protein 0.0013 0.0025 0.0026
Loa Loa (eye worm) hypothetical protein 0.0023 0.0248 0.0281
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0076 0.1358 1
Schistosoma mansoni zinc finger protein 0.002 0.0174 0.0263
Echinococcus granulosus inositol monophosphatase 1 0.0076 0.1358 0.2171
Mycobacterium ulcerans glutaminase 0.0273 0.5527 1
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0076 0.1358 0.1299
Brugia malayi F/Y-rich N-terminus family protein 0.0014 0.005 0.0054
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0438 0.2867
Plasmodium falciparum importin beta, putative 0.0029 0.0369 0.0337
Brugia malayi hypothetical protein 0.0015 0.0068 0.0075
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.006 0.1021 0.1632
Loa Loa (eye worm) hypothetical protein 0.0015 0.0068 0.0075
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0078 0.1411 0.2244
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0036 0.0519 0.083
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0076 0.1358 0.1299
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0429 0.0686
Echinococcus granulosus calcium dependent protein kinase 0.003 0.0388 0.062
Brugia malayi major facilitator superfamily protein 0.0015 0.0068 0.0075
Toxoplasma gondii Erv1 / Alr family protein 0.0034 0.0485 0.0712
Loa Loa (eye worm) glutaminase 0.0273 0.5527 0.6311
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0031 0.0416 0.065
Toxoplasma gondii lysine-tRNA ligase 0.0023 0.0248 0.0308
Plasmodium falciparum FAD-linked sulfhydryl oxidase ERV1, putative 0.0034 0.0485 0.0466
Trypanosoma cruzi ISWI complex protein 0.0015 0.0084 0.0124
Loa Loa (eye worm) hypothetical protein 0.0125 0.2396 0.2734
Echinococcus multilocularis zinc finger protein 0.002 0.0174 0.0278
Brugia malayi intermediate filament protein 0.0027 0.033 0.0374
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0032 0.0429 0.2801
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0726 0.0826
Trichomonas vaginalis glutaminase, putative 0.0273 0.5527 0.5497
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0076 0.1358 0.2362
Echinococcus granulosus solute carrier family 22 0.0015 0.0068 0.0109
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0376 0.0601
Loa Loa (eye worm) sugar transporter 0.0015 0.0068 0.0075
Brugia malayi jmjC domain containing protein 0.0095 0.1775 0.2025
Loa Loa (eye worm) sugar transporter 0.0103 0.1943 0.2216
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0121 0.0178
Plasmodium falciparum protein kinase 6 0.0439 0.9019 1
Echinococcus multilocularis snurportin 1 0.0308 0.6254 1
Brugia malayi Sugar transporter family protein 0.0103 0.1943 0.2216
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0121 0.0193
Leishmania major glucose transporter, lmgt3 0.0032 0.0438 0.2867
Trypanosoma brucei glucose transporter, putative 0.0032 0.0438 0.2867
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0209 0.0236
Onchocerca volvulus 0.0027 0.033 0.0264
Schistosoma mansoni hypothetical protein 0.0103 0.1943 0.3095
Plasmodium falciparum calcium-dependent protein kinase 5 0.0032 0.043 0.0404
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0076 0.1358 1
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0103 0.1943 0.3106
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0209 0.0157
Schistosoma mansoni transient receptor potential channel 0.0199 0.3957 0.6321
Echinococcus granulosus snurportin 1 0.0308 0.6254 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0094 0.0104
Schistosoma mansoni lamin 0.0027 0.033 0.0513
Brugia malayi hypothetical protein 0.0015 0.0068 0.0075
Leishmania major GTP-binding protein, putative 0.0021 0.0209 0.1093
Echinococcus granulosus histone lysine methyltransferase setb 0.0078 0.1411 0.2256
Schistosoma mansoni transient receptor potential channel 0.0132 0.2536 0.4046
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0726 0.1161
Schistosoma mansoni inositol monophosphatase 0.0076 0.1358 0.2159
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.006 0.1021 0.1632
Loa Loa (eye worm) jmjC domain-containing protein 0.006 0.1031 0.1175
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0068 0.0075
Brugia malayi Pre-SET motif family protein 0.0061 0.1052 0.1198
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0726 0.1161
Schistosoma mansoni bromodomain containing protein 0.0063 0.1096 0.174
Schistosoma mansoni hypothetical protein 0.0016 0.0094 0.0135
Brugia malayi Sugar transporter family protein 0.0015 0.0068 0.0075
Loa Loa (eye worm) hypothetical protein 0.0071 0.1253 0.1428
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0066 0.0072
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.002 0.0175 0.0951
Loa Loa (eye worm) inositol-1 0.0076 0.1358 0.1548
Loa Loa (eye worm) hypothetical protein 0.0015 0.0068 0.0075
Echinococcus granulosus transient receptor potential ion channel A 0.0192 0.3817 0.6103
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0376 0.0601
Plasmodium falciparum calcium-dependent protein kinase 4 0.0032 0.043 0.0404
Echinococcus granulosus solute carrier family 22 0.0015 0.0068 0.0109
Loa Loa (eye worm) hepatopoietin HPO2 0.0034 0.0485 0.0551
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0023 0.0237 0.0364
Echinococcus granulosus short transient receptor potential channel 6 0.0132 0.2536 0.4055
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0032 0.0429 0.0487
Echinococcus multilocularis GPCR, family 2 0.0016 0.0094 0.015
Brugia malayi Importin beta-1 subunit 0.0029 0.0369 0.0419
Echinococcus granulosus intermediate filament protein 0.0027 0.033 0.0528
Loa Loa (eye worm) hypothetical protein 0.0015 0.0068 0.0075
Echinococcus granulosus GPCR family 2 0.0016 0.0094 0.015
Loa Loa (eye worm) hypothetical protein 0.0015 0.0068 0.0075
Schistosoma mansoni protein kinase 0.0032 0.0429 0.0672
Brugia malayi Bromodomain containing protein 0.0038 0.0569 0.0647
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0726 0.1161
Plasmodium falciparum calcium-dependent protein kinase 2 0.0032 0.043 0.0404
Trichomonas vaginalis conserved hypothetical protein 0.0103 0.1943 0.1887
Loa Loa (eye worm) hypothetical protein 0.0041 0.0621 0.0706
Schistosoma mansoni ran 0.0021 0.0209 0.0319
Schistosoma mansoni hypothetical protein 0.0021 0.0196 0.0299
Schistosoma mansoni transient receptor potential channel 4 0.0199 0.3957 0.6321
Plasmodium falciparum lysine--tRNA ligase 0.0023 0.0248 0.0201
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0248 0.0382
Echinococcus granulosus zinc finger protein 0.002 0.0174 0.0278
Loa Loa (eye worm) hypothetical protein 0.0199 0.3957 0.4517
Loa Loa (eye worm) intermediate filament protein 0.0027 0.033 0.0374
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0068 0.0075
Echinococcus granulosus solute carrier family 22 0.0015 0.0068 0.0109
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0059 0.1004 0.1605
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0308 0.6254 0.7141
Toxoplasma gondii facilitative glucose transporter GT1 0.0103 0.1943 0.3201
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0248 0.033
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.0429 0.0686
Loa Loa (eye worm) hypothetical protein 0.0029 0.0369 0.0419
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0095 0.1775 0.2839
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0376 0.0526
Loa Loa (eye worm) hypothetical protein 0.0027 0.033 0.0374
Loa Loa (eye worm) hypothetical protein 0.0025 0.0293 0.0332
Trypanosoma brucei glucose transporter, putative 0.0032 0.0438 0.2867
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0369 0.0515
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0036 0.0524 0.3537
Echinococcus granulosus fetal alzheimer antigen falz 0.0023 0.0237 0.0379
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0438 0.0372
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0023 0.0248 0.0723
Brugia malayi PHD-finger family protein 0.0025 0.0287 0.0325
Echinococcus granulosus General substrate transporter 0.0089 0.1636 0.2616
Giardia lamblia PHD finger protein 15 0.0029 0.0376 0.8865
Entamoeba histolytica protein kinase, putative 0.0032 0.0429 0.1918
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0209 0.0236
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0726 0.1161
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0095 0.1775 0.2839
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0032 0.043 0.0404
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0103 0.1943 0.3106
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0068 0.0075
Echinococcus multilocularis transient receptor potential ion channel A 0.0192 0.3817 0.6103
Plasmodium falciparum hexose transporter 0.0103 0.1943 0.2094
Plasmodium vivax proline--tRNA ligase, putative 0.0036 0.0524 0.051
Echinococcus granulosus FAD linked sulfhydryl oxidase ALR 0.0034 0.0485 0.0775
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0031 0.0416 0.065
Brugia malayi Bromodomain containing protein 0.0075 0.1343 0.1531
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0438 0.0372
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.0429 0.0686
Schistosoma mansoni hypothetical protein 0.0016 0.0094 0.0135
Echinococcus granulosus lamin 0.0027 0.033 0.0528
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0438 0.0372
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0429 0.0686
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0076 0.1358 0.2202
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0078 0.1411 0.2256
Loa Loa (eye worm) hypothetical protein 0.0043 0.0661 0.0752
Echinococcus multilocularis solute carrier family 22 0.0015 0.0068 0.0109
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0369 0.2338
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0023 0.0237 0.0379
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0103 0.1943 0.3106
Echinococcus granulosus jumonji domain containing protein 0.0041 0.0617 0.0987
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0438 0.2867
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0438 0.2867
Trypanosoma cruzi hexose transporter, putative 0.0018 0.0131 0.0489
Plasmodium falciparum phd finger protein, putative 0.0029 0.0376 0.0344
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0031 0.0416 0.0472
Schistosoma mansoni glucose transport protein 0.0103 0.1943 0.3095
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.033 0.0374
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0121 0.0193
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0254 0.0188
Echinococcus granulosus lysine specific demethylase 5A 0.0037 0.0546 0.0873
Echinococcus multilocularis musashi 0.0027 0.033 0.0528
Brugia malayi jmjC domain containing protein 0.0037 0.0546 0.0621
Schistosoma mansoni glucose transporter 0.0015 0.0068 0.0093
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.0196 0.0222
Echinococcus granulosus lamin dm0 0.0027 0.033 0.0528
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0813 0.0926
Schistosoma mansoni sugar transporter 0.0015 0.0068 0.0093
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0032 0.043 0.0617
Leishmania major protein kinase, putative 0.0032 0.0429 0.2801
Schistosoma mansoni glucose transport protein 0.0103 0.1943 0.3095
Trichomonas vaginalis glucose transporter, putative 0.0032 0.0438 0.0372
Echinococcus granulosus importin subunit beta 1 0.0029 0.0369 0.0591
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0209 0.1093
Loa Loa (eye worm) bromodomain containing protein 0.0018 0.0134 0.015
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.048 0.0545
Schistosoma mansoni lamin 0.0027 0.033 0.0513
Brugia malayi Inositol-1 0.0076 0.1358 0.1548
Giardia lamblia Lysyl-tRNA synthetase 0.0023 0.0248 0.5182
Brugia malayi Sugar transporter family protein 0.0015 0.0068 0.0075
Schistosoma mansoni glutaminase 0.0273 0.5527 0.8836
Loa Loa (eye worm) hypothetical protein 0.0074 0.1322 0.1507
Echinococcus multilocularis inositol monophosphatase 1 0.0076 0.1358 0.2171
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0376 0.0344
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0438 0.2867
Trypanosoma cruzi ERV/ALR sulfhydryl oxidase domain-containing protein 0.0034 0.0485 0.3232
Plasmodium vivax FAD-linked sulfhydryl oxidase ERV1, putative 0.0034 0.0485 0.0466
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0031 0.0416 0.2372
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0032 0.0429 0.0487
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0032 0.043 0.0404
Loa Loa (eye worm) hypothetical protein 0.005 0.0813 0.0926
Entamoeba histolytica hypothetical protein 0.0023 0.0248 0.0342
Loa Loa (eye worm) hypothetical protein 0.0015 0.0068 0.0075
Echinococcus granulosus lysyl tRNA synthetase 0.0023 0.0248 0.0397
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0813 0.0926
Loa Loa (eye worm) hypothetical protein 0.0013 0.0036 0.0038
Onchocerca volvulus 0.0061 0.1052 0.099
Trypanosoma brucei glucose transporter, putative 0.0032 0.0438 0.2867
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0036 0.0057
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0726 0.1147
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0034 0.0485 0.3232
Loa Loa (eye worm) hypothetical protein 0.005 0.0816 0.0929
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0031 0.0416 0.18
Brugia malayi PHD-finger family protein 0.0029 0.0376 0.0427
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0209 0.0334
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0209 0.0241
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0036 0.0524 0.3537
Loa Loa (eye worm) jmjC domain-containing protein 0.0037 0.0546 0.0621
Plasmodium falciparum proline--tRNA ligase 0.0036 0.0524 0.051
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0015 0.0068 0.0093
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.002 0.0188 0.0121
Loa Loa (eye worm) hypothetical protein 0.0015 0.0068 0.0075
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0429 0.0686
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0369 0.2338
Loa Loa (eye worm) hypothetical protein 0.0034 0.048 0.0545
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0103 0.1943 0.3106
Echinococcus granulosus TRP transient receptor potential channel 0.0074 0.1322 0.2113
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0094 0.0104
Plasmodium vivax CDK-related protein kinase 6, putative 0.0439 0.9019 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0094 0.015
Trypanosoma brucei ISWI complex protein 0.0015 0.0084 0.0124
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0209 0.0157
Schistosoma mansoni jumonji domain containing protein 0.0076 0.1361 0.2165
Loa Loa (eye worm) hypothetical protein 0.0016 0.0094 0.0104
Echinococcus multilocularis lamin dm0 0.0027 0.033 0.0528
Trypanosoma cruzi hexose transporter 0.0032 0.0438 0.2867
Loa Loa (eye worm) hypothetical protein 0.0015 0.0068 0.0075
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0438 0.0372
Schistosoma mansoni jumonji/arid domain-containing protein 0.0037 0.0546 0.0859
Leishmania major hypothetical protein, conserved 0.0015 0.0084 0.0124
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0254 0.0188
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0438 0.0372
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0036 0.0519 0.083
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0031 0.0416 0.0665
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0013 0.003 0.0031
Brugia malayi lysyl-tRNA synthetase 0.0023 0.0248 0.0281
Loa Loa (eye worm) hypothetical protein 0.0015 0.0068 0.0075
Schistosoma mansoni sugar transporter 0.0015 0.0068 0.0093
Loa Loa (eye worm) hypothetical protein 0.0032 0.0429 0.0487
Echinococcus granulosus transient receptor potential gamma protein 0.0199 0.3957 0.6326
Loa Loa (eye worm) hypothetical protein 0.0015 0.0068 0.0075
Leishmania major hypothetical protein, conserved 0.0034 0.0485 0.3232
Loa Loa (eye worm) hypothetical protein 0.0015 0.0068 0.0075
Brugia malayi Cam kinase protein 1 0.0032 0.0429 0.0487
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.033 0.0374
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0061 0.1052 0.1681
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0426 0.8757 1
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0076 0.1358 1
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0254 0.0188
Echinococcus multilocularis short transient receptor potential channel 6 0.0132 0.2536 0.4055
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0032 0.043 0.0617
Toxoplasma gondii protein kinase, putative 0.0292 0.5924 1
Plasmodium falciparum mitogen-activated protein kinase 2 0.0167 0.3286 0.3595
Schistosoma mansoni ran 0.0021 0.0209 0.0319
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0032 0.0429 0.0686
Brugia malayi Augmenter of liver regeneration 0.0034 0.0485 0.0551
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0121 0.0178
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.0524 0.3537
Loa Loa (eye worm) hypothetical protein 0.0038 0.0571 0.0649
Brugia malayi hypothetical protein 0.0015 0.0068 0.0075
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.0524 0.3537
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0103 0.1943 0.3106
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0023 0.0248 0.0181
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0103 0.1943 0.3106
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0078 0.1411 0.2244
Entamoeba histolytica protein kinase, putative 0.0032 0.0429 0.1918
Loa Loa (eye worm) hypothetical protein 0.0015 0.0068 0.0075
Trichomonas vaginalis CAMK family protein kinase 0.0032 0.0429 0.0364
Schistosoma mansoni protein kinase 0.0032 0.0429 0.0672
Echinococcus multilocularis short transient receptor potential channel 6 0.0132 0.2536 0.4055
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0248 0.033
Echinococcus multilocularis lamin 0.0027 0.033 0.0528
Schistosoma mansoni sugar transporter 0.0015 0.0068 0.0093
Echinococcus multilocularis solute carrier family 22 0.0015 0.0068 0.0109
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0061 0.1052 0.168
Trypanosoma brucei glucose transporter, putative 0.0032 0.0438 0.2867
Loa Loa (eye worm) hypothetical protein 0.0015 0.0068 0.0075
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0076 0.1358 1
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0376 0.0526
Echinococcus multilocularis lysine specific demethylase 5A 0.0035 0.0506 0.0808
Brugia malayi Transient-receptor-potential like protein 0.0074 0.1322 0.1507
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0103 0.1943 0.3106
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0103 0.1943 0.3106
Leishmania major glucose transporter/membrane transporter D2, putative 0.0032 0.0438 0.2867
Brugia malayi Pre-SET motif family protein 0.0426 0.8757 1
Schistosoma mansoni hypothetical protein 0.0016 0.0094 0.0135
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0094 0.015
Schistosoma mansoni hypothetical protein 0.0034 0.048 0.0753
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0248 0.0382
Trypanosoma cruzi ISWI complex protein 0.0015 0.0084 0.0124
Echinococcus multilocularis transient receptor potential gamma protein 0.0199 0.3957 0.6326
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0076 0.1358 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0416 0.0472
Leishmania major lysyl-tRNA synthetase, putative 0.0023 0.0248 0.1397
Entamoeba histolytica hypothetical protein 0.0023 0.0254 0.0396
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0094 0.015
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0438 0.2867
Echinococcus granulosus solute carrier family 22 0.0015 0.0068 0.0109
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0094 0.0104
Echinococcus multilocularis synaptic vesicle 2 protein 0.0015 0.0068 0.0109
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0031 0.0416 0.0665
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0066 0.0072
Echinococcus multilocularis peregrin 0.0032 0.0426 0.0681
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0209 0.1093
Trichomonas vaginalis glucose transporter, putative 0.0032 0.0438 0.0372
Trypanosoma brucei glucose transporter 2A 0.0032 0.0438 0.2867
Schistosoma mansoni hypothetical protein 0.0308 0.6254 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0416 0.0472
Echinococcus granulosus Sugar transporter ERD6 protein 0.0015 0.0068 0.0109
Echinococcus multilocularis FAD linked sulfhydryl oxidase ALR 0.0034 0.0485 0.0775
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0209 0.1093
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0076 0.1358 1
Trichomonas vaginalis ran, putative 0.0021 0.0209 0.0142
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0032 0.0429 0.0487
Schistosoma mansoni hypothetical protein 0.0029 0.0376 0.0587
Brugia malayi RNA, U transporter 1 0.0082 0.1491 0.17
Loa Loa (eye worm) major facilitator superfamily transporter 0.0015 0.0068 0.0075
Loa Loa (eye worm) hypothetical protein 0.0013 0.0025 0.0026
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0023 0.0248 0.1397
Plasmodium vivax SET domain protein, putative 0.0061 0.1052 0.1099
Brugia malayi major facilitator superfamily protein 0.0015 0.0068 0.0075
Schistosoma mansoni inositol monophosphatase 0.0076 0.1358 0.2159
Loa Loa (eye worm) glutaminase 2 0.0273 0.5527 0.6311
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0209 0.4053
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0438 0.2867
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0209 0.0334
Plasmodium vivax importin-beta 2, putative 0.0029 0.0369 0.0337
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0369 0.0591
Brugia malayi glutaminase DH11.1 0.0273 0.5527 0.6311
Loa Loa (eye worm) hypothetical protein 0.0029 0.0376 0.0427
Plasmodium vivax lysine--tRNA ligase, putative 0.0023 0.0248 0.0201
Echinococcus granulosus peregrin 0.0032 0.0426 0.0681
Trichomonas vaginalis set domain proteins, putative 0.0485 1 1
Schistosoma mansoni protein kinase 0.0032 0.0429 0.0672
Schistosoma mansoni zinc finger protein 0.0015 0.0084 0.0119
Schistosoma mansoni transient receptor potential channel 0.0132 0.2536 0.4046
Giardia lamblia Prolyl-tRNA synthetase 0.0031 0.0416 1
Leishmania major glucose transporter, lmgt2 0.0032 0.0438 0.2867
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0015 0.0068 0.0109
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0167 0.3286 0.5495
Echinococcus multilocularis General substrate transporter 0.0089 0.1636 0.2616
Plasmodium falciparum protein kinase 7 0.0292 0.5924 0.6542
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0094 0.015
Loa Loa (eye worm) hypothetical protein 0.0015 0.0068 0.0075
Schistosoma mansoni importin beta-1 0.0029 0.0369 0.0576
Leishmania major glucose transporter, lmgt1 0.0032 0.0438 0.2867
Schistosoma mansoni intermediate filament proteins 0.0027 0.033 0.0513
Echinococcus multilocularis solute carrier family 22 0.0015 0.0068 0.0109
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0376 0.0427
Onchocerca volvulus 0.0027 0.033 0.0264
Schistosoma mansoni sugar transporter 0.0015 0.0068 0.0093
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0813 0.0926
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0036 0.0524 0.0779
Plasmodium vivax hexose transporter 0.0103 0.1943 0.2094
Schistosoma mansoni glucose transport protein 0.0103 0.1943 0.3095
Trypanosoma brucei glucose transporter, putative 0.0032 0.0438 0.2867
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0023 0.0248 0.1397
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0032 0.043 0.0617
Leishmania major importin beta-1 subunit, putative 0.0023 0.0254 0.1446
Loa Loa (eye worm) hypothetical protein 0.0015 0.0068 0.0075
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0032 0.043 0.0404
Trypanosoma brucei ERV/ALR sulfhydryl oxidase domain-containing protein 0.0034 0.0485 0.3232
Loa Loa (eye worm) hypothetical protein 0.0078 0.1411 0.1609
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0726 0.1147
Plasmodium falciparum calcium-dependent protein kinase 3 0.0032 0.043 0.0404
Schistosoma mansoni hypothetical protein 0.0016 0.0094 0.0135
Echinococcus multilocularis calcium dependent protein kinase 0.003 0.0388 0.062
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.002 0.0175 0.0951
Echinococcus multilocularis solute carrier family 22 0.0015 0.0068 0.0109
Loa Loa (eye worm) major facilitator superfamily transporter 0.0015 0.0068 0.0075
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0034 0.0485 0.3232
Loa Loa (eye worm) hypothetical protein 0.0015 0.0068 0.0075
Chlamydia trachomatis lysine--tRNA ligase 0.0023 0.0248 0.5
Schistosoma mansoni hypothetical protein 0.0015 0.0084 0.0119
Loa Loa (eye worm) hypothetical protein 0.0067 0.1182 0.1347
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0726 0.1147
Trichomonas vaginalis inositol monophosphatase, putative 0.0076 0.1358 0.1299
Schistosoma mansoni jumonji/arid domain-containing protein 0.0037 0.0546 0.0859
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0031 0.0416 0.035
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0429 0.0686
Trypanosoma brucei glucose transporter, putative 0.0032 0.0438 0.2867
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0061 0.1052 0.1668
Schistosoma mansoni serine/threonine protein kinase 0.0032 0.0429 0.0672
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0068 0.119 1
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0068 0.119 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0726 0.0826
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0036 0.0057
Trypanosoma brucei glucose transporter, putative 0.0032 0.0438 0.2867
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0254 0.1446
Loa Loa (eye worm) hypothetical protein 0.0026 0.032 0.0362
Onchocerca volvulus Alhambra homolog 0.0029 0.0376 0.031
Plasmodium vivax calcium-dependent protein kinase, putative 0.0032 0.043 0.0404
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.0429 0.0686
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0074 0.1322 0.2113
Echinococcus granulosus synaptic vesicle 2 protein 0.0015 0.0068 0.0109
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.1052 0.1668
Plasmodium falciparum calcium-dependent protein kinase 1 0.0032 0.043 0.0404
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0167 0.3286 0.3595
Trypanosoma brucei glucose transporter, putative 0.0032 0.0438 0.2867
Echinococcus multilocularis lysyl tRNA synthetase 0.0023 0.0248 0.0397
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.0524 0.3537
Echinococcus granulosus short transient receptor potential channel 6 0.0132 0.2536 0.4055

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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