Detailed information for compound 714992

Basic information

Technical information
  • TDR Targets ID: 714992
  • Name: dimethyl 4-(3-bromo-4-methoxyphenyl)-1-[(4-fl uorophenyl)methyl]-4H-pyridine-3,5-dicarboxyl ate
  • MW: 490.319 | Formula: C23H21BrFNO5
  • H donors: 0 H acceptors: 2 LogP: 4.2 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC(=O)C1=CN(Cc2ccc(cc2)F)C=C(C1c1ccc(c(c1)Br)OC)C(=O)OC
  • InChi: 1S/C23H21BrFNO5/c1-29-20-9-6-15(10-19(20)24)21-17(22(27)30-2)12-26(13-18(21)23(28)31-3)11-14-4-7-16(25)8-5-14/h4-10,12-13,21H,11H2,1-3H3
  • InChiKey: PWGMSIDIQTXDRO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • dimethyl 4-(3-bromo-4-methoxy-phenyl)-1-[(4-fluorophenyl)methyl]-4H-pyridine-3,5-dicarboxylate
  • 4-(3-bromo-4-methoxyphenyl)-1-[(4-fluorophenyl)methyl]-4H-pyridine-3,5-dicarboxylic acid dimethyl ester
  • 4-(3-bromo-4-methoxy-phenyl)-1-(4-fluorobenzyl)-4H-pyridine-3,5-dicarboxylic acid dimethyl ester
  • IVK/2007414
  • EU-0065656
  • ZINC02853663

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis Mastin 0.0015 0.0031 0.0031
Brugia malayi Trypsin-like protease protein 5 0.0015 0.0031 0.02
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0022 0.0124 0.1545
Loa Loa (eye worm) bone morphogenetic protein 1b 0.0014 0.0026 0.0168
Echinococcus multilocularis 1 phosphatidylinositol 4,5 bisphosphate 0.0019 0.009 0.009
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0295 0.1084
Onchocerca volvulus 0.0035 0.0296 0.3696
Loa Loa (eye worm) hypothetical protein 0.0015 0.0031 0.02
Loa Loa (eye worm) Plcb4 protein 0.0018 0.0077 0.0497
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0024 0.0111
Loa Loa (eye worm) hypothetical protein 0.0014 0.0026 0.0168
Loa Loa (eye worm) casein kinase II 0.0022 0.0124 0.0803
Loa Loa (eye worm) hypothetical protein 0.0036 0.0301 0.1951
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0014 0.0024 0.0111
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0054 0.0542 0.2533
Plasmodium vivax acetyl-CoA synthetase, putative 0.0014 0.0024 0.0111
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0048 0.0455 0.2124
Brugia malayi Low-density lipoprotein receptor repeat class B containing protein 0.0014 0.0026 0.0168
Leishmania major hypothetical protein, conserved 0.0035 0.0295 0.3689
Trichomonas vaginalis casein kinase II beta chain, putative 0.0075 0.08 0.3667
Schistosoma mansoni cercarial elastase (S01 family) 0.0015 0.0031 0.0374
Mycobacterium ulcerans hypothetical protein 0.0035 0.0295 0.1379
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0276 0.1012
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0015 0.0031 0.0374
Toxoplasma gondii PAN domain-containing protein 0.0035 0.0296 0.0731
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0076 0.0823 0.0823
Trichomonas vaginalis casein kinase II beta chain, putative 0.0075 0.08 0.3667
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0014 0.0024 0.0296
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.005 0.0486 0.1785
Loa Loa (eye worm) hypothetical protein 0.0015 0.0031 0.02
Onchocerca volvulus Casein kinase II subunit beta homolog 0.0075 0.08 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0048 0.0455 0.2124
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0076 0.0823 1
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0014 0.0024 0.0296
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0048 0.0455 0.167
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0014 0.0024 0.0087
Loa Loa (eye worm) hypothetical protein 0.0035 0.0295 0.1916
Loa Loa (eye worm) TK/ROR protein kinase 0.0054 0.0542 0.352
Loa Loa (eye worm) PAN domain-containing protein 0.0035 0.0296 0.1919
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0026 0.0182 0.0849
Loa Loa (eye worm) beta-lactamase 0.0035 0.0295 0.1916
Brugia malayi Fibulin-1 precursor 0.0014 0.0026 0.0168
Toxoplasma gondii phosphoinositide phospholipase PIPLC 0.0019 0.009 0.0224
Loa Loa (eye worm) hypothetical protein 0.0048 0.0455 0.2952
Echinococcus multilocularis Tolloid protein 1 0.0014 0.0026 0.0026
Trichomonas vaginalis casein kinase II beta chain, putative 0.0075 0.08 0.3667
Trichomonas vaginalis casein kinase II beta chain, putative 0.0075 0.08 0.3667
Brugia malayi PAN domain containing protein 0.0035 0.0296 0.1919
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0276 0.1012
Loa Loa (eye worm) multiple epidermal growth factor-like domains 6 0.0014 0.0026 0.0168
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0014 0.0024 0.0111
Toxoplasma gondii microneme protein MIC17A 0.0035 0.0296 0.0731
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0024 0.0087
Trichomonas vaginalis casein kinase II beta chain, putative 0.0022 0.0124 0.0472
Onchocerca volvulus 0.0014 0.0024 0.0296
Plasmodium vivax enoyl-acyl carrier protein reductase 0.0179 0.2141 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0024 0.0111
Echinococcus granulosus tissue type plasminogen activator 0.0054 0.0542 0.6586
Loa Loa (eye worm) hypothetical protein 0.0015 0.0031 0.02
Onchocerca volvulus 0.0015 0.0031 0.0385
Onchocerca volvulus 0.0035 0.0296 0.3696
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0455 0.2124
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0048 0.0455 0.2124
Onchocerca volvulus 0.0035 0.0296 0.3696
Brugia malayi PAN domain containing protein 0.0035 0.0296 0.1919
Brugia malayi Kringle domain containing protein 0.0054 0.0542 0.352
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0024 0.0111
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0014 0.0024 0.0111
Trichomonas vaginalis casein kinase II beta chain, putative 0.0022 0.0124 0.0472
Mycobacterium ulcerans enoyl-(acyl carrier protein) reductase 0.0179 0.2141 1
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0014 0.0024 0.0111
Loa Loa (eye worm) hypothetical protein 0.0054 0.0542 0.352
Loa Loa (eye worm) hypothetical protein 0.0015 0.0031 0.02
Mycobacterium ulcerans lipase LipD 0.0035 0.0295 0.1379
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0455 0.2952
Brugia malayi 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 4 0.0018 0.0077 0.0497
Trypanosoma cruzi phosphoinositide-specific phospholipase C, putative 0.0019 0.009 0.1131
Loa Loa (eye worm) hypothetical protein 0.0036 0.0301 0.1951
Onchocerca volvulus 0.0035 0.0296 0.3696
Trichomonas vaginalis casein kinase II beta chain, putative 0.0022 0.0124 0.0472
Loa Loa (eye worm) hypothetical protein 0.0035 0.0296 0.1919
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0295 0.1084
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0024 0.0087
Schistosoma mansoni cercarial elastase (S01 family) 0.0015 0.0031 0.0374
Toxoplasma gondii microneme protein MIC17C 0.0035 0.0296 0.0731
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0014 0.0024 0.0111
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0295 0.0295
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0076 0.0823 0.3846
Trichomonas vaginalis casein kinase II beta chain, putative 0.0075 0.08 0.3667
Schistosoma mansoni cercarial elastase (S01 family) 0.0015 0.0031 0.0374
Brugia malayi beta-lactamase family protein 0.0035 0.0295 0.1916
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0295 0.1084
Trichomonas vaginalis casein kinase II beta chain, putative 0.0075 0.08 0.3667
Leishmania major phosphatidylinositol-specific phospholipase-like protein 0.0018 0.0077 0.0956
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0295 0.1282
Loa Loa (eye worm) hypothetical protein 0.0035 0.0295 0.1916
Trypanosoma brucei Casein kinase II subunit beta, putative 0.0075 0.08 1
Trichomonas vaginalis casein kinase II beta chain, putative 0.0022 0.0124 0.0472
Trichomonas vaginalis casein kinase II beta chain, putative 0.0075 0.08 0.3667
Loa Loa (eye worm) hypothetical protein 0.0015 0.0031 0.02
Onchocerca volvulus Casein kinase II subunit beta homolog 0.0075 0.08 1
Brugia malayi PAN domain containing protein 0.0035 0.0296 0.1919
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0076 0.0823 0.3846
Toxoplasma gondii microneme protein, putative 0.0035 0.0296 0.0731
Trichomonas vaginalis casein kinase II beta chain, putative 0.0075 0.08 0.3667
Plasmodium vivax casein kinase II beta chain, putative 0.0075 0.08 0.3737
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0014 0.0024 0.0296
Loa Loa (eye worm) hypothetical protein 0.0035 0.0296 0.1919
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0014 0.0024 0.0154
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0014 0.0024 0.0059
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0295 0.1379
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0076 0.0823 0.3846
Loa Loa (eye worm) hypothetical protein 0.0036 0.0301 0.1951
Loa Loa (eye worm) hypothetical protein 0.0014 0.0024 0.0154
Echinococcus granulosus enteropeptidase 0.0015 0.0031 0.0374
Schistosoma mansoni cercarial elastase (S01 family) 0.0015 0.0031 0.0374
Trichomonas vaginalis casein kinase II beta chain, putative 0.0022 0.0124 0.0472
Toxoplasma gondii PAN/Apple domain-containing protein 0.0035 0.0296 0.0731
Loa Loa (eye worm) hypothetical protein 0.0015 0.0031 0.02
Toxoplasma gondii PAN domain-containing protein 0.0328 0.4044 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0296 0.1919
Plasmodium falciparum phosphoinositide-specific phospholipase C 0.0018 0.0077 0.0357
Leishmania major acetyl-CoA synthetase, putative 0.0014 0.0024 0.0296
Loa Loa (eye worm) hypothetical protein 0.0076 0.0823 0.5345
Loa Loa (eye worm) hypothetical protein 0.0014 0.0026 0.0168
Loa Loa (eye worm) trypsin family protein 0.0015 0.0031 0.02
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0276 0.1012
Toxoplasma gondii PAN domain-containing protein 0.0035 0.0296 0.0731
Loa Loa (eye worm) hypothetical protein 0.0015 0.0031 0.02
Echinococcus multilocularis transmembrane protease serine 3 0.0015 0.0031 0.0031
Onchocerca volvulus 0.0035 0.0295 0.3689
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0295 0.1282
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0036 0.0301 0.1404
Trichomonas vaginalis protein kinase ck2-beta, putative 0.0022 0.0124 0.0472
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.005 0.0486 0.2271
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0295 0.1084
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0455 0.2124
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0076 0.0823 0.3846
Brugia malayi PAN domain containing protein 0.0035 0.0296 0.1919
Onchocerca volvulus 0.0015 0.0031 0.0385
Leishmania major protein kinase ck2 regulatory subunit, putative 0.0075 0.08 1
Echinococcus multilocularis peptidase Clp (S14 family) 0.005 0.0486 0.0486
Toxoplasma gondii microneme protein MIC17B 0.0035 0.0296 0.0731
Onchocerca volvulus 0.0015 0.0031 0.0385
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0295 0.3585
Brugia malayi Csnk2b protein 0.0075 0.08 0.5194
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0295 0.1084
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0295 0.3689
Brugia malayi Protein kinase domain containing protein 0.0054 0.0542 0.352
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0014 0.0024 0.0087
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0295 0.1282
Loa Loa (eye worm) hypothetical protein 0.0035 0.0295 0.1916
Trichomonas vaginalis hypothetical protein 0.0179 0.2141 1
Brugia malayi PAN domain containing protein 0.0035 0.0296 0.1919
Loa Loa (eye worm) Csnk2b protein 0.0075 0.08 0.5194
Trichomonas vaginalis esterase, putative 0.0035 0.0295 0.1282
Brugia malayi Probable ClpP-like protease 0.0076 0.0823 0.5345
Echinococcus granulosus 1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-4 0.0019 0.009 0.1099
Schistosoma mansoni phospholipase C beta 0.0018 0.0077 0.0929
Plasmodium vivax acyl-CoA synthetase, putative 0.0036 0.0301 0.1404
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0014 0.0024 0.0111
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0015 0.0031 0.0374
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0225 0.2724 1
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0014 0.0024 0.0154
Onchocerca volvulus Arrow homolog 0.0014 0.0026 0.0323
Loa Loa (eye worm) hypothetical protein 0.0018 0.0077 0.0497
Loa Loa (eye worm) hypothetical protein 0.0014 0.0026 0.0168
Loa Loa (eye worm) hypothetical protein 0.0035 0.0295 0.1916
Trichomonas vaginalis casein kinase II beta chain, putative 0.0075 0.08 0.3667
Loa Loa (eye worm) hypothetical protein 0.0019 0.009 0.0587
Plasmodium falciparum enoyl-acyl carrier reductase 0.0179 0.2141 1
Schistosoma mansoni cercarial elastase (S01 family) 0.0015 0.0031 0.0374
Mycobacterium tuberculosis Conserved protein 0.0035 0.0295 0.1084
Loa Loa (eye worm) phosphatidylinositol-specific phospholipase C 0.0019 0.009 0.0587
Brugia malayi PAN domain containing protein 0.0035 0.0296 0.1919
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0295 0.1379
Schistosoma mansoni cercarial elastase (S01 family) 0.0015 0.0031 0.0374
Trypanosoma cruzi Casein kinase II subunit beta, putative 0.0075 0.08 1
Plasmodium falciparum casein kinase II beta chain 0.0075 0.08 0.3737
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0014 0.0024 0.0296
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0015 0.0031 0.0374
Echinococcus granulosus Tolloid protein 1 0.0014 0.0026 0.0314
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0295 0.1282
Toxoplasma gondii PAN domain-containing protein 0.0035 0.0296 0.0731
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0015 0.0031 0.0374
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0014 0.0024 0.0288
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0024 0.0111
Schistosoma mansoni hypothetical protein 0.0015 0.0031 0.0374
Trichomonas vaginalis casein kinase II beta chain, putative 0.0022 0.0124 0.0472
Onchocerca volvulus 0.0035 0.0296 0.3696
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0014 0.0024 0.0087
Brugia malayi Calcium binding EGF domain containing protein 0.0014 0.0026 0.0168
Onchocerca volvulus 0.0048 0.0455 0.5684
Loa Loa (eye worm) hypothetical protein 0.0019 0.009 0.0587
Schistosoma mansoni casein kinase II beta subunit 0.0075 0.08 0.9718
Schistosoma mansoni cercarial elastase (S01 family) 0.0015 0.0031 0.0374
Mycobacterium leprae NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) 0.0179 0.2141 1
Loa Loa (eye worm) PAN domain-containing protein 0.0035 0.0296 0.1919
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0295 0.1282
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0024 0.0154
Onchocerca volvulus 0.0015 0.0031 0.0385
Toxoplasma gondii PAN domain-containing protein 0.0328 0.4044 1
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0295 0.3689
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0015 0.0031 0.0374
Onchocerca volvulus 0.0035 0.0296 0.3696
Plasmodium falciparum casein kinase II beta chain 0.0075 0.08 0.3737
Trichomonas vaginalis casein kinase II beta chain, putative 0.0075 0.08 0.3667
Loa Loa (eye worm) hypothetical protein 0.0035 0.0296 0.1919
Leishmania major phosphoinositide-specific phospholipase C, putative 0.0018 0.0077 0.0956
Toxoplasma gondii enoyl-acyl carrier reductase ENR 0.0179 0.2141 0.5294
Brugia malayi Trypsin family protein 0.0015 0.0031 0.02
Brugia malayi beta-lactamase 0.0035 0.0295 0.1916
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0014 0.0024 0.0111
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0048 0.0455 0.167
Onchocerca volvulus 0.0015 0.0031 0.0385
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0014 0.0024 0.0087
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0024 0.0111
Onchocerca volvulus 0.0035 0.0296 0.3696
Trichomonas vaginalis casein kinase II beta chain, putative 0.0075 0.08 0.3667
Echinococcus granulosus Mastin 0.0015 0.0031 0.0374
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.005 0.0486 0.1785
Toxoplasma gondii 1,3(4)-beta-glucanase 0.0035 0.0296 0.0731
Toxoplasma gondii microneme protein MIC4 0.0035 0.0296 0.0731
Toxoplasma gondii calcium binding egf domain-containing protein 0.0014 0.0026 0.0064
Onchocerca volvulus 0.0015 0.0031 0.0385
Onchocerca volvulus 0.0035 0.0296 0.3696
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0276 0.1012
Loa Loa (eye worm) hypothetical protein 0.0014 0.0024 0.0154
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0014 0.0024 0.0087
Echinococcus multilocularis laminin 0.0014 0.0026 0.0026
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0015 0.0031 0.0031
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0014 0.0024 0.0059
Toxoplasma gondii hypothetical protein 0.0026 0.0182 0.0449
Toxoplasma gondii ABC1 family protein 0.0035 0.0295 0.073
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0295 0.1379
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0048 0.0455 0.2124
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0014 0.0024 0.0296
Trichomonas vaginalis casein kinase II beta chain, putative 0.0022 0.0124 0.0472
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0076 0.0823 0.3846
Toxoplasma gondii PAN domain-containing protein 0.0035 0.0296 0.0731
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0014 0.0024 0.0087
Schistosoma mansoni hypothetical protein 0.0015 0.0031 0.0374
Plasmodium vivax phospholipase C-like, putative 0.0018 0.0077 0.0357
Loa Loa (eye worm) hypothetical protein 0.0048 0.0455 0.2952
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0014 0.0024 0.0111
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0076 0.0823 1
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0295 0.1379
Onchocerca volvulus 0.0014 0.0024 0.0296
Brugia malayi Phosphatidylinositol-specific phospholipase C, X domain containing protein 0.0018 0.0077 0.0497
Brugia malayi PAN domain containing protein 0.0035 0.0296 0.1919
Loa Loa (eye worm) PAN domain-containing protein 0.0035 0.0296 0.1919
Brugia malayi PAN domain containing protein 0.0035 0.0296 0.1919
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0014 0.0024 0.0087
Plasmodium falciparum acyl-CoA synthetase 0.0036 0.0301 0.1404
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0015 0.0031 0.02
Brugia malayi Variant SH3 domain containing protein 0.0132 0.154 1
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0014 0.0024 0.0296
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0026 0.0182 0.0849
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0024 0.0111
Wolbachia endosymbiont of Brugia malayi enoyl-ACP reductase 0.0179 0.2141 1
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0024 0.0154
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0015 0.0031 0.0374
Toxoplasma gondii propionate-CoA ligase 0.0014 0.0024 0.0059
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0015 0.0031 0.0374
Trichomonas vaginalis casein kinase II beta chain, putative 0.0022 0.0124 0.0472
Onchocerca volvulus 0.0019 0.009 0.1131
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0076 0.0823 0.2036
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0014 0.0024 0.0111
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.0455 0.5684
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0014 0.0024 0.0111
Onchocerca volvulus 0.0035 0.0295 0.3689
Toxoplasma gondii kringle domain-containing protein 0.0054 0.0542 0.1341
Leishmania major acetyl-CoA synthetase, putative 0.0014 0.0024 0.0296
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0015 0.0031 0.0374
Loa Loa (eye worm) hypothetical protein 0.0035 0.0296 0.1919
Onchocerca volvulus 0.0035 0.0296 0.3696
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0132 0.154 1
Schistosoma mansoni cercarial elastase (S01 family) 0.0015 0.0031 0.0374
Loa Loa (eye worm) hypothetical protein 0.0048 0.0455 0.2952
Trichomonas vaginalis casein kinase II beta chain, putative 0.0075 0.08 0.3667
Toxoplasma gondii hypothetical protein 0.0035 0.0296 0.0731
Trichomonas vaginalis casein kinase II beta chain, putative 0.0075 0.08 0.3667
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0295 0.1084
Echinococcus multilocularis casein kinase ii subunit beta 0.0075 0.08 0.08
Loa Loa (eye worm) hypothetical protein 0.0014 0.0026 0.0168
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0024 0.0154
Brugia malayi Trypsin family protein 0.0015 0.0031 0.02
Mycobacterium tuberculosis Conserved protein 0.0035 0.0295 0.1084
Toxoplasma gondii calcium binding egf domain-containing protein 0.0014 0.0026 0.0064
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0048 0.0455 0.2124
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0014 0.0024 0.0154
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0015 0.0031 0.0374
Schistosoma mansoni egf-like domain protein 0.0014 0.0026 0.0314
Mycobacterium tuberculosis NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) 0.0179 0.2141 0.786
Trichomonas vaginalis casein kinase II beta chain, putative 0.0022 0.0124 0.0472
Schistosoma mansoni hypothetical protein 0.0054 0.0542 0.6586
Onchocerca volvulus 0.0035 0.0296 0.3696
Plasmodium vivax casein kinase II beta chain, putative 0.0075 0.08 0.3737
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0014 0.0024 0.0296
Echinococcus granulosus peptidase Clp S14 family 0.005 0.0486 0.5904
Trichomonas vaginalis protein kinase ck2-beta, putative 0.0022 0.0124 0.0472
Trichomonas vaginalis casein kinase II beta chain, putative 0.0075 0.08 0.3667
Trichomonas vaginalis casein kinase II beta chain, putative 0.0075 0.08 0.3667
Onchocerca volvulus 0.0019 0.009 0.1131
Leishmania major hypothetical protein, conserved 0.0054 0.0542 0.6777
Leishmania major phospholipase c-like protein 0.0019 0.009 0.1131
Trichomonas vaginalis casein kinase II beta chain, putative 0.0022 0.0124 0.0472
Mycobacterium ulcerans hypothetical protein 0.0015 0.0031 0.0144
Toxoplasma gondii hypothetical protein 0.0035 0.0296 0.0731
Loa Loa (eye worm) PAN domain-containing protein 0.0035 0.0296 0.1919
Brugia malayi PAN domain containing protein 0.0035 0.0296 0.1919
Schistosoma mansoni cercarial elastase (S01 family) 0.0015 0.0031 0.0374
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0024 0.0111
Echinococcus multilocularis fibrillin 1 0.0014 0.0026 0.0026
Schistosoma mansoni cercarial elastase (S01 family) 0.0015 0.0031 0.0374
Plasmodium falciparum cysteine repeat modular protein 1 0.0054 0.0542 0.2533
Echinococcus granulosus casein kinase ii subunit beta 0.0075 0.08 0.9718
Mycobacterium ulcerans hypothetical protein 0.0048 0.0455 0.2124
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0014 0.0024 0.0111
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0455 0.2952
Mycobacterium tuberculosis Conserved protein 0.0035 0.0295 0.1084
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0024 0.0111
Onchocerca volvulus 0.0014 0.0024 0.0296
Schistosoma mansoni cercarial elastase (S01 family) 0.0015 0.0031 0.0374
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0036 0.0301 0.1404
Schistosoma mansoni acetyl-CoA synthetase 0.0014 0.0024 0.0288
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0295 0.3585
Brugia malayi casein kinase II, putaitve 0.0022 0.0124 0.0803
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0075 0.08 1
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0295 0.1084
Trypanosoma cruzi Casein kinase II subunit beta, putative 0.0075 0.08 1
Mycobacterium ulcerans beta-lactamase 0.0035 0.0295 0.1379
Entamoeba histolytica acyl-CoA synthetase, putative 0.0048 0.0455 0.5684
Loa Loa (eye worm) hypothetical protein 0.0036 0.0301 0.1951
Trichomonas vaginalis casein kinase II beta chain, putative 0.0022 0.0124 0.0472
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0048 0.0455 0.2124
Giardia lamblia Casein kinase II beta chain 0.0075 0.08 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.0455 0.5684
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0024 0.0087
Trichomonas vaginalis casein kinase II beta chain, putative 0.0022 0.0124 0.0472
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0076 0.0823 0.3846
Echinococcus granulosus transmembrane protease serine 3 0.0015 0.0031 0.0374
Mycobacterium leprae Probable lipase LipE 0.0035 0.0295 0.1379
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0076 0.0823 0.3846
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0295 0.3689
Loa Loa (eye worm) hypothetical protein 0.0035 0.0295 0.1916
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.0455 0.5684
Trypanosoma brucei phosphoinositide-specific phospholipase C 0.0019 0.009 0.1131
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0015 0.0031 0.0031
Trichomonas vaginalis casein kinase II beta chain, putative 0.0022 0.0124 0.0472
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0295 0.1916
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0024 0.0087
Onchocerca volvulus 0.0014 0.0024 0.0296
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0295 0.3585
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0455 0.2124
Echinococcus granulosus laminin 0.0014 0.0026 0.0314
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0076 0.0823 0.3846
Onchocerca volvulus 0.0035 0.0296 0.3696
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0014 0.0024 0.0111
Onchocerca volvulus 0.0054 0.0542 0.6777
Echinococcus granulosus glycoprotein Antigen 5 0.0015 0.0031 0.0374
Entamoeba histolytica acyl-CoA synthetase, putative 0.0048 0.0455 0.5684
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0076 0.0823 0.2036
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0075 0.08 1
Brugia malayi PAN domain containing protein 0.0035 0.0296 0.1919
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0036 0.0301 0.1103
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0295 0.1916
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0014 0.0024 0.0296
Loa Loa (eye worm) hypothetical protein 0.0035 0.0296 0.1919
Chlamydia trachomatis enoyl-acyl-carrier protein reductase 0.0179 0.2141 1
Toxoplasma gondii ck2 beta subunit 0.0075 0.08 0.1979
Loa Loa (eye worm) hypothetical protein 0.0035 0.0295 0.1916
Schistosoma mansoni peptidase Clp (S14 family) 0.0076 0.0823 1
Loa Loa (eye worm) low-density lipoprotein receptor repeat class B containing protein 0.0014 0.0026 0.0168
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0022 0.0124 0.1545
Toxoplasma gondii subtilisin SUB12 0.0035 0.0296 0.0731
Brugia malayi beta-lactamase family protein 0.0035 0.0295 0.1916
Loa Loa (eye worm) hypothetical protein 0.0035 0.0296 0.1919
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) 0.0014 0.0026 0.0314
Mycobacterium ulcerans acetyl-CoA synthetase 0.0014 0.0024 0.0111
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0015 0.0031 0.0374
Loa Loa (eye worm) PAN domain-containing protein 0.0035 0.0296 0.1919
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0024 0.0154
Loa Loa (eye worm) oxidoreductase 0.0014 0.0024 0.0154
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0014 0.0024 0.0024
Echinococcus multilocularis enteropeptidase 0.0015 0.0031 0.0031
Trypanosoma cruzi hypothetical protein, conserved 0.0054 0.0542 0.6777
Brugia malayi Trypsin family protein 0.0015 0.0031 0.02
Brugia malayi Phosphatidylinositol-specific phospholipase C, X domain containing protein 0.0019 0.009 0.0587
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0455 0.2952
Echinococcus multilocularis tissue type plasminogen activator 0.0054 0.0542 0.0542
Entamoeba histolytica acyl-coA synthetase, putative 0.0048 0.0455 0.5684
Onchocerca volvulus 0.0035 0.0295 0.3689
Brugia malayi Trypsin family protein 0.0015 0.0031 0.02
Loa Loa (eye worm) hypothetical protein 0.0036 0.0301 0.1951
Toxoplasma gondii casein kinase ii regulatory subunit protein 0.0075 0.08 0.1979
Echinococcus multilocularis glycoprotein Antigen 5 0.0015 0.0031 0.0031
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0014 0.0024 0.0154
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0075 0.08 1
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0026 0.0182 0.0849
Brugia malayi hypothetical protein 0.0015 0.0031 0.02
Loa Loa (eye worm) hypothetical protein 0.0014 0.0026 0.0168

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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