Detailed information for compound 718703

Basic information

Technical information
  • TDR Targets ID: 718703
  • Name: 1-(4-ethoxyphenyl)-N-(furan-2-ylmethyl)-5-oxo pyrrolidine-3-carboxamide
  • MW: 328.362 | Formula: C18H20N2O4
  • H donors: 1 H acceptors: 2 LogP: 1.2 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOc1ccc(cc1)N1CC(CC1=O)C(=O)NCc1ccco1
  • InChi: 1S/C18H20N2O4/c1-2-23-15-7-5-14(6-8-15)20-12-13(10-17(20)21)18(22)19-11-16-4-3-9-24-16/h3-9,13H,2,10-12H2,1H3,(H,19,22)
  • InChiKey: ASORGOZBVALPBV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-(4-ethoxyphenyl)-N-(2-furylmethyl)-5-oxo-pyrrolidine-3-carboxamide
  • 1-(4-ethoxyphenyl)-N-(2-furylmethyl)-5-oxo-3-pyrrolidinecarboxamide
  • 1-(4-ethoxyphenyl)-N-(2-furylmethyl)-5-keto-pyrrolidine-3-carboxamide
  • 1-(4-ethoxyphenyl)-N-(furan-2-ylmethyl)-5-oxo-pyrrolidine-3-carboxamide
  • Oprea1_412251
  • A2458/0104312
  • BAS 07576427

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus cathepsin l1 0.0017 0.0183 0.0523
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0103 0.2108 0.6032
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.032 0.1997
Trypanosoma cruzi cysteine peptidase, putative 0.0064 0.1243 0.8867
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0031 0.0496 0.142
Brugia malayi major facilitator superfamily protein 0.0014 0.0129 0.0254
Entamoeba histolytica protein kinase, putative 0.0031 0.0511 0.8364
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.1243 0.8867
Plasmodium falciparum calcium-dependent protein kinase 2 0.0031 0.0511 0.0534
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0014 0.0129 0.037
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0183 0.0867
Echinococcus multilocularis cysteine protease 0.0017 0.0183 0.0523
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0103 0.2108 0.6032
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0129 0.0614
Schistosoma mansoni hypothetical protein 0.0035 0.059 0.1688
Trichomonas vaginalis myo-inositol transporter, putative 0.0014 0.0129 0.0614
Loa Loa (eye worm) hypothetical protein 0.0014 0.0129 0.0245
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.1243 0.8867
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.032 0.1997
Brugia malayi Cathepsin L-like precursor 0.0017 0.0183 0.0359
Loa Loa (eye worm) hypothetical protein 0.0031 0.0511 0.0994
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0129 0.0614
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0611 0.2897
Leishmania major cathepsin L-like protease 0.0064 0.1243 0.8752
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.1243 0.8867
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0036 0.0611 0.1747
Leishmania major cathepsin L-like protease 0.0064 0.1243 0.8752
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0129 0.0614
Entamoeba histolytica cysteine protease, putative 0.0017 0.0183 0.2995
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0129 0.0614
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0511 0.1461
Plasmodium falciparum calcium-dependent protein kinase 5 0.0031 0.0511 0.0534
Brugia malayi lysyl-tRNA synthetase 0.0023 0.032 0.0627
Echinococcus granulosus cathepsin l1 0.0011 0.0058 0.0166
Loa Loa (eye worm) hypothetical protein 0.0014 0.0129 0.0245
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.0611 0.4359
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0129 0.0614
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0071 0.1401 0.1289
Leishmania major glucose transporter, lmgt1 0.0032 0.052 0.3068
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0071 0.1401 0.2744
Plasmodium vivax calcium-dependent protein kinase, putative 0.0031 0.0511 0.0534
Onchocerca volvulus Putative transporter 0.0014 0.0129 0.053
Trypanosoma cruzi hexose transporter, putative 0.0017 0.0196 0.1399
Schistosoma mansoni protein kinase 0.0031 0.0511 0.1461
Brugia malayi Cathepsin L-like precursor 0.0017 0.0183 0.0359
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0031 0.0511 0.0994
Brugia malayi beta-lactamase family protein 0.0071 0.1401 0.2752
Brugia malayi beta-lactamase 0.0071 0.1401 0.2752
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.052 0.3709
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0129 0.0614
Echinococcus granulosus solute carrier family 22 0.0014 0.0129 0.037
Onchocerca volvulus 0.0014 0.0129 0.053
Brugia malayi Sugar transporter family protein 0.0014 0.0129 0.0254
Loa Loa (eye worm) hypothetical protein 0.0014 0.0129 0.0245
Loa Loa (eye worm) Smad1 0.0016 0.0166 0.0316
Brugia malayi Major Facilitator Superfamily protein 0.0014 0.0129 0.0254
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.032 0.0915
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0031 0.0511 0.1003
Loa Loa (eye worm) hypothetical protein 0.0036 0.0611 0.119
Onchocerca volvulus Cathepsin L homolog 0.0017 0.0183 0.0928
Echinococcus granulosus solute carrier family 22 0.0014 0.0129 0.037
Schistosoma mansoni sugar transporter 0.0014 0.0129 0.037
Onchocerca volvulus 0.0017 0.0183 0.0928
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0183 0.0867
Onchocerca volvulus Cathepsin L homolog 0.0017 0.0183 0.0928
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0031 0.0511 0.0534
Onchocerca volvulus 0.0014 0.0129 0.053
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0014 0.0129 0.059
Echinococcus multilocularis geminin 0.0164 0.3495 1
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.0611 0.3785
Loa Loa (eye worm) hypothetical protein 0.0014 0.0129 0.0245
Plasmodium vivax proline--tRNA ligase, putative 0.0036 0.0611 0.0638
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0129 0.0614
Brugia malayi Cathepsin L-like precursor 0.0011 0.0058 0.0114
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0023 0.032 0.0668
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0031 0.0496 0.813
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0129 0.0614
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0103 0.2108 0.6032
Plasmodium falciparum protein kinase 6 0.0436 0.9577 1
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0031 0.0511 0.1461
Echinococcus granulosus cathepsin L cysteine proteinase 0.0017 0.0183 0.0523
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0183 0.0523
Schistosoma mansoni hypothetical protein 0.0164 0.3495 1
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0129 0.0614
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0023 0.032 0.2281
Toxoplasma gondii facilitative glucose transporter GT1 0.0103 0.2108 0.3201
Mycobacterium tuberculosis Probable hydrolase 0.0071 0.1401 0.1289
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0031 0.0496 0.0975
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0129 0.0614
Loa Loa (eye worm) hypothetical protein 0.0014 0.0129 0.0245
Onchocerca volvulus 0.0071 0.1401 1
Leishmania major cathepsin L-like protease 0.0017 0.0183 0.042
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.1243 0.8867
Onchocerca volvulus 0.0014 0.0129 0.053
Loa Loa (eye worm) hypothetical protein 0.0017 0.0183 0.035
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0129 0.0614
Plasmodium vivax hypothetical protein, conserved 0.0071 0.1401 0.1463
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.052 0.2465
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0017 0.0183 0.0191
Onchocerca volvulus 0.0071 0.1401 1
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.0183 0.2995
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0183 0.0867
Loa Loa (eye worm) hypothetical protein 0.0031 0.0496 0.0966
Schistosoma mansoni smad1 5 8 and 0.0016 0.0166 0.0475
Schistosoma mansoni smad1 5 8 and 0.0016 0.0166 0.0475
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0103 0.2108 0.6032
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.052 0.2465
Trichomonas vaginalis sugar transporter, putative 0.0032 0.052 0.2465
Brugia malayi MH1 domain containing protein 0.0016 0.0166 0.0326
Schistosoma mansoni sugar transporter 0.0014 0.0129 0.037
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0031 0.0496 0.142
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0129 0.0614
Leishmania major lysyl-tRNA synthetase, putative 0.0023 0.032 0.1495
Onchocerca volvulus 0.0014 0.0129 0.053
Echinococcus multilocularis solute carrier family 22 0.0014 0.0129 0.037
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0023 0.032 0.1516
Mycobacterium ulcerans integral membrane transport protein 0.0014 0.0129 0.059
Brugia malayi Cathepsin L-like cysteine proteinase 0.0011 0.0058 0.0114
Trypanosoma brucei sugar transporter, putative 0.0014 0.0129 0.0924
Trypanosoma brucei glucose transporter, putative 0.0032 0.052 0.3709
Onchocerca volvulus 0.0014 0.0129 0.053
Loa Loa (eye worm) hypothetical protein 0.0014 0.0129 0.0245
Echinococcus multilocularis lysyl tRNA synthetase 0.0023 0.032 0.0915
Loa Loa (eye worm) MH2 domain-containing protein 0.0236 0.5093 1
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0103 0.2108 0.6032
Trypanosoma cruzi hexose transporter, putative 0.0014 0.0129 0.0924
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0183 0.0867
Trypanosoma cruzi hexose transporter, putative 0.0032 0.052 0.3709
Plasmodium vivax sugar transporter, putative 0.0014 0.0129 0.0135
Brugia malayi Smad1 0.0016 0.0166 0.0326
Echinococcus granulosus synaptic vesicle 2 protein 0.0014 0.0129 0.037
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0183 0.0523
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0183 0.0867
Entamoeba histolytica hypothetical protein 0.0023 0.032 0.5234
Loa Loa (eye worm) hypothetical protein 0.0011 0.0058 0.0105
Loa Loa (eye worm) hypothetical protein 0.0071 0.1401 0.2744
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.059 0.1688
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0183 0.0523
Echinococcus multilocularis solute carrier family 22 0.0014 0.0129 0.037
Trichomonas vaginalis penicillin-binding protein, putative 0.0071 0.1401 0.6648
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0031 0.0496 0.2355
Schistosoma mansoni smad 0.0016 0.0166 0.0475
Plasmodium falciparum protein kinase 7 0.029 0.631 0.6589
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0511 0.1461
Loa Loa (eye worm) hypothetical protein 0.0071 0.1401 0.2744
Mycobacterium ulcerans beta-lactamase 0.0071 0.1401 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.1243 0.8867
Loa Loa (eye worm) hypothetical protein 0.0014 0.0129 0.0245
Echinococcus granulosus calcium dependent protein kinase 0.0029 0.0467 0.1337
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0014 0.0129 0.037
Giardia lamblia Prolyl-tRNA synthetase 0.0031 0.0496 0.7627
Trichomonas vaginalis sugar transporter, putative 0.0032 0.052 0.2465
Trypanosoma cruzi cysteine peptidase, putative 0.0064 0.1243 0.8867
Onchocerca volvulus 0.0014 0.0129 0.053
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0129 0.0614
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0017 0.0183 0.035
Leishmania major cathepsin L-like protease 0.0017 0.0183 0.042
Echinococcus granulosus General substrate transporter 0.0088 0.1784 0.5106
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0129 0.0614
Echinococcus multilocularis synaptic vesicle 2 protein 0.0014 0.0129 0.037
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0611 0.4357
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0036 0.0611 0.1747
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0016 0.0166 0.0475
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.1401 0.6648
Mycobacterium tuberculosis Conserved protein 0.0071 0.1401 0.1289
Echinococcus granulosus cathepsin l cysteine peptidase 0.0017 0.0183 0.0523
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0071 0.1401 0.401
Entamoeba histolytica hypothetical protein 0.0035 0.059 0.966
Leishmania major cathepsin L-like protease 0.0017 0.0183 0.042
Brugia malayi MH2 domain containing protein 0.0236 0.5093 1
Mycobacterium tuberculosis Probable lipase LipE 0.0071 0.1401 0.1289
Schistosoma mansoni hypothetical protein 0.0103 0.2108 0.6032
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.1243 0.8867
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0183 0.0867
Plasmodium falciparum calcium-dependent protein kinase 4 0.0031 0.0511 0.0534
Trichomonas vaginalis glucose transporter, putative 0.0032 0.052 0.2465
Brugia malayi MH2 domain containing protein 0.0016 0.0166 0.0326
Trypanosoma brucei glucose transporter, putative 0.0032 0.052 0.3709
Plasmodium falciparum hexose transporter 0.0103 0.2108 0.2201
Plasmodium falciparum mitogen-activated protein kinase 2 0.0166 0.3526 0.3682
Entamoeba histolytica protein kinase, putative 0.0031 0.0511 0.8364
Loa Loa (eye worm) hypothetical protein 0.0011 0.0058 0.0105
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.059 0.1688
Trypanosoma brucei glucose transporter, putative 0.0032 0.052 0.3709
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0017 0.0183 0.0191
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0129 0.0614
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0129 0.0614
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0611 0.4357
Schistosoma mansoni protein kinase 0.0031 0.0511 0.1461
Trypanosoma cruzi glucose transporter, putative 0.0014 0.0129 0.0924
Trypanosoma brucei glucose transporter 2A 0.0032 0.052 0.3709
Brugia malayi Sugar transporter family protein 0.0014 0.0129 0.0254
Schistosoma mansoni glucose transport protein 0.0103 0.2108 0.6032
Brugia malayi Major Facilitator Superfamily protein 0.0014 0.0129 0.0254
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0511 0.1461
Onchocerca volvulus 0.0014 0.0129 0.053
Leishmania major cysteine peptidase A (CPA) 0.0017 0.0183 0.042
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0129 0.0614
Giardia lamblia Lysyl-tRNA synthetase 0.0023 0.032 0.3952
Schistosoma mansoni Smad4 0.0016 0.0166 0.0475
Onchocerca volvulus 0.0014 0.0129 0.053
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0129 0.0614
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0183 0.0867
Plasmodium falciparum calcium-dependent protein kinase 1 0.0031 0.0511 0.0534
Onchocerca volvulus 0.0014 0.0129 0.053
Trichomonas vaginalis penicillin-binding protein, putative 0.0071 0.1401 0.6648
Treponema pallidum prolyl-tRNA synthetase 0.0011 0.005 0.5
Schistosoma mansoni glucose transporter 0.0014 0.0129 0.037
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.1401 1
Loa Loa (eye worm) major facilitator superfamily transporter 0.0014 0.0129 0.0245
Onchocerca volvulus Cathepsin F homolog 0.0017 0.0183 0.0928
Loa Loa (eye worm) hypothetical protein 0.0014 0.0129 0.0245
Trypanosoma cruzi hexose transporter, putative 0.0032 0.052 0.3709
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0031 0.0496 0.142
Onchocerca volvulus 0.0014 0.0129 0.053
Toxoplasma gondii protein kinase, putative 0.029 0.631 1
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0014 0.0129 0.0135
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.1243 0.8867
Brugia malayi MH1 domain containing protein 0.0009 0.0005 0.001
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.059 0.1688
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0183 0.0867
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0183 0.0867
Loa Loa (eye worm) hypothetical protein 0.0014 0.0129 0.0245
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0017 0.0183 0.0867
Chlamydia trachomatis lysine--tRNA ligase 0.0023 0.032 1
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.0611 0.2897
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0129 0.0614
Echinococcus granulosus Sugar transporter ERD6 protein 0.0014 0.0129 0.037
Echinococcus granulosus mothers against decapentaplegic 5 0.0016 0.0166 0.0475
Echinococcus multilocularis solute carrier family 22 0.0014 0.0129 0.037
Mycobacterium ulcerans sugar transporter 0.0014 0.0129 0.059
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0611 0.4357
Entamoeba histolytica hypothetical protein 0.0035 0.059 0.966
Leishmania major cathepsin L-like protease 0.0064 0.1243 0.8752
Leishmania major protein kinase, putative 0.0031 0.0511 0.2997
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0129 0.0614
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0036 0.0611 0.1747
Loa Loa (eye worm) hypothetical protein 0.0014 0.0129 0.0245
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0183 0.0867
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0129 0.0614
Leishmania major glucose transporter/membrane transporter D2, putative 0.0032 0.052 0.3068
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0036 0.0611 0.0779
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0129 0.0614
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.052 0.3709
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.002 0.0256 0.1216
Loa Loa (eye worm) sugar transporter 0.0103 0.2108 0.4133
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.1243 0.8867
Loa Loa (eye worm) hypothetical protein 0.0071 0.1401 0.2744
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0129 0.0614
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0183 0.0523
Plasmodium falciparum cysteine proteinase falcipain 3 0.0017 0.0183 0.0191
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0036 0.0611 0.1747
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0129 0.0614
Loa Loa (eye worm) hypothetical protein 0.0031 0.0496 0.0966
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0129 0.0614
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0511 0.1461
Plasmodium vivax lysine--tRNA ligase, putative 0.0023 0.032 0.0334
Trypanosoma cruzi hexose transporter, putative 0.0032 0.052 0.3709
Trypanosoma brucei glucose transporter, putative 0.0032 0.052 0.3709
Plasmodium falciparum lysine--tRNA ligase 0.0023 0.032 0.0334
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0031 0.0511 0.0617
Trichomonas vaginalis sugar transport protein, putative 0.0014 0.0129 0.0614
Echinococcus granulosus ubiquitin specific protease 41 0.0036 0.0611 0.1747
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0129 0.0614
Loa Loa (eye worm) cysteine protease 0.0017 0.0183 0.035
Loa Loa (eye worm) major facilitator superfamily transporter 0.0014 0.0129 0.0245
Trichomonas vaginalis esterase, putative 0.0071 0.1401 0.6648
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0129 0.0614
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0183 0.0867
Leishmania major glucose transporter, lmgt2 0.0032 0.052 0.3068
Brugia malayi MH1 domain containing protein 0.0016 0.0166 0.0326
Brugia malayi MH2 domain containing protein 0.0016 0.0166 0.0326
Onchocerca volvulus 0.0017 0.0183 0.0928
Trichomonas vaginalis CAMK family protein kinase 0.0031 0.0511 0.2423
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0071 0.1401 0.2752
Loa Loa (eye worm) ctsf protein 0.0017 0.0183 0.035
Toxoplasma gondii lysine-tRNA ligase 0.0023 0.032 0.0308
Loa Loa (eye worm) hypothetical protein 0.0071 0.1401 0.2744
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0013 0.0089 0.0166
Plasmodium vivax vivapain-2 0.0017 0.0183 0.0191
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0014 0.0129 0.5
Echinococcus multilocularis ubiquitin specific protease 41 0.0036 0.0611 0.1747
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0183 0.0867
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0036 0.0611 0.4359
Loa Loa (eye worm) MH2 domain-containing protein 0.0016 0.0166 0.0316
Brugia malayi Cathepsin L-like precursor 0.0017 0.0183 0.0359
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0036 0.0611 0.4359
Leishmania major hypothetical protein, conserved 0.0071 0.1401 1
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0071 0.1401 0.1289
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0031 0.0511 0.0534
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0183 0.0867
Echinococcus granulosus TGF beta signal transducer SmadC 0.0016 0.0166 0.0475
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0031 0.0496 0.2193
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0031 0.0511 0.0617
Mycobacterium tuberculosis Probable esterase LipL 0.0071 0.1401 0.1289
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0036 0.0611 0.1199
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0183 0.0867
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.0183 0.0359
Schistosoma mansoni sugar transporter 0.0014 0.0129 0.037
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0129 0.0614
Mycobacterium ulcerans esterase/lipase LipP 0.0071 0.1401 1
Trichomonas vaginalis conserved hypothetical protein 0.0103 0.2108 1
Brugia malayi major facilitator superfamily protein 0.0014 0.0129 0.0254
Brugia malayi beta-lactamase family protein 0.0071 0.1401 0.2752
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0031 0.0496 0.142
Echinococcus multilocularis beta LACTamase domain containing family member 0.0071 0.1401 0.401
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0036 0.0611 0.1747
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0183 0.0867
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0031 0.0511 0.0534
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0011 0.0058 0.0276
Loa Loa (eye worm) fibroinase 0.0017 0.0183 0.035
Trypanosoma brucei glucose transporter, putative 0.0032 0.052 0.3709
Echinococcus multilocularis smad 0.0016 0.0166 0.0475
Trichomonas vaginalis glucose transporter, putative 0.0032 0.052 0.2465
Schistosoma mansoni cathepsin F (C01 family) 0.0011 0.0058 0.0166
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.032 0.0915
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.1401 0.6648
Brugia malayi hypothetical protein 0.0035 0.059 0.1158
Leishmania major glucose transporter, lmgt3 0.0032 0.052 0.3068
Entamoeba histolytica hypothetical protein 0.0035 0.059 0.966
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0183 0.0867
Onchocerca volvulus 0.0017 0.0183 0.0928
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0031 0.0511 0.3644
Onchocerca volvulus 0.0017 0.0183 0.0928
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0071 0.1401 1
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0017 0.0183 0.035
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0019 0.0242 0.0114
Mycobacterium tuberculosis Probable lipase LipD 0.0071 0.1401 0.1289
Loa Loa (eye worm) sugar transporter 0.0014 0.0129 0.0245
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0031 0.0511 0.1461
Onchocerca volvulus 0.0017 0.0183 0.0928
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0129 0.0614
Brugia malayi cathepsin L-like precursor 0.0011 0.0058 0.0114
Brugia malayi Cathepsin L-like precursor 0.0017 0.0183 0.0359
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0031 0.0496 0.0975
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0183 0.0523
Mycobacterium ulcerans hypothetical protein 0.0071 0.1401 1
Loa Loa (eye worm) transcription factor SMAD2 0.0236 0.5093 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0129 0.0245
Trypanosoma cruzi major cysteine proteinase, putative 0.005 0.0935 0.6673
Schistosoma mansoni sugar transporter 0.0014 0.0129 0.037
Echinococcus multilocularis cysteine protease 0.0017 0.0183 0.0523
Trichomonas vaginalis glucose transporter, putative 0.0014 0.0129 0.0614
Onchocerca volvulus 0.0017 0.0183 0.0928
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0031 0.0511 0.1461
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0183 0.0867
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0036 0.0611 0.1747
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.0611 0.3785
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0014 0.0129 0.059
Brugia malayi Major Facilitator Superfamily protein 0.0014 0.0129 0.0254
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0031 0.0511 0.1461
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0183 0.0867
Brugia malayi hypothetical protein 0.0014 0.0129 0.0254
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0017 0.0183 0.0867
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0129 0.0614
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0103 0.2108 0.6032
Echinococcus granulosus Smad4 0.0016 0.0166 0.0475
Brugia malayi Sugar transporter family protein 0.0103 0.2108 0.4139
Brugia malayi Cathepsin L-like precursor 0.0017 0.0183 0.0359
Trypanosoma cruzi cysteine peptidase, putative 0.0017 0.0183 0.1305
Plasmodium vivax vivapain-2 0.0017 0.0183 0.0191
Echinococcus multilocularis mothers against decapentaplegic 5 0.0016 0.0166 0.0475
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0036 0.0611 0.3783
Trypanosoma cruzi hexose transporter 0.0032 0.052 0.3709
Toxoplasma gondii ABC1 family protein 0.0071 0.1401 0.2058
Plasmodium vivax hexose transporter 0.0103 0.2108 0.2201
Echinococcus multilocularis solute carrier family 22 0.0014 0.0129 0.037
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0071 0.1401 0.1289
Loa Loa (eye worm) MH1 domain-containing protein 0.0016 0.0166 0.0316
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0129 0.0614
Trypanosoma cruzi cruzipain precursor, putative 0.0064 0.1243 0.8867
Brugia malayi hypothetical protein 0.0014 0.0129 0.0254
Onchocerca volvulus 0.0014 0.0129 0.053
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.1243 0.8867
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0129 0.0614
Onchocerca volvulus 0.0014 0.0129 0.053
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0103 0.2108 0.6032
Echinococcus multilocularis calcium dependent protein kinase 0.0029 0.0467 0.1337
Toxoplasma gondii cathepsin CPL 0.0017 0.0183 0.0086
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.052 0.3709
Onchocerca volvulus 0.0014 0.0129 0.053
Echinococcus granulosus solute carrier family 22 0.0014 0.0129 0.037
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0031 0.0511 0.0994
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0019 0.0242 0.0114
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0059 0.1118 0.7977
Echinococcus granulosus beta LACTamase domain containing family member 0.0071 0.1401 0.401
Loa Loa (eye worm) hypothetical protein 0.0014 0.0129 0.0245
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.0611 0.2897
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0103 0.2108 0.6032
Onchocerca volvulus 0.0071 0.1401 1
Leishmania major cathepsin L-like protease 0.0017 0.0183 0.042
Loa Loa (eye worm) hypothetical protein 0.0014 0.0129 0.0245
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0036 0.0611 1
Trypanosoma cruzi sugar transporter, putative 0.0014 0.0129 0.0924
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.1243 0.8867
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.1243 0.8867
Brugia malayi Cam kinase protein 1 0.0031 0.0511 0.1003
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0016 0.0166 0.0475
Schistosoma mansoni protein kinase 0.0031 0.0511 0.1461
Loa Loa (eye worm) hypothetical protein 0.0011 0.0058 0.0105
Mycobacterium leprae Probable lipase LipE 0.0071 0.1401 1
Plasmodium vivax CDK-related protein kinase 6, putative 0.0436 0.9577 1
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0166 0.3526 0.5495
Echinococcus multilocularis Smad4 0.0016 0.0166 0.0475
Mycobacterium leprae conserved hypothetical protein 0.0071 0.1401 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0011 0.0058 0.0276
Loa Loa (eye worm) hypothetical protein 0.0014 0.0129 0.0245
Mycobacterium ulcerans lipase LipD 0.0071 0.1401 1
Onchocerca volvulus 0.0014 0.0129 0.053
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0183 0.0867
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0014 0.0129 0.0924
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0166 0.3526 0.3682
Schistosoma mansoni glucose transport protein 0.0103 0.2108 0.6032
Trypanosoma brucei hypothetical protein, conserved 0.0071 0.1401 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0183 0.0867
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0071 0.1401 0.401
Schistosoma mansoni serine/threonine protein kinase 0.0031 0.0511 0.1461
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.1401 1
Onchocerca volvulus 0.0017 0.0183 0.0928
Brugia malayi Cathepsin L-like precursor 0.0011 0.0058 0.0114
Leishmania major cathepsin L-like protease 0.0017 0.0183 0.042
Echinococcus granulosus solute carrier family 22 0.0014 0.0129 0.037
Plasmodium falciparum calcium-dependent protein kinase 3 0.0031 0.0511 0.0534
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0183 0.0523
Schistosoma mansoni smad1 5 8 and 0.0016 0.0166 0.0475
Brugia malayi hypothetical protein 0.0014 0.0129 0.0254
Echinococcus multilocularis General substrate transporter 0.0088 0.1784 0.5106
Entamoeba histolytica cysteine proteinase, putative 0.0011 0.0058 0.0953
Trypanosoma brucei glucose transporter 1E 0.0032 0.052 0.3709
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.0183 0.2995
Loa Loa (eye worm) hypothetical protein 0.0023 0.032 0.0618
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0129 0.0614
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0183 0.0867
Loa Loa (eye worm) beta-lactamase 0.0071 0.1401 0.2744
Onchocerca volvulus 0.0014 0.0129 0.053
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0036 0.0611 1
Schistosoma mansoni hypothetical protein 0.0164 0.3495 1
Loa Loa (eye worm) hypothetical protein 0.0071 0.1401 0.2744
Onchocerca volvulus 0.0014 0.0129 0.053
Loa Loa (eye worm) hypothetical protein 0.0014 0.0129 0.0245
Trypanosoma cruzi cysteine peptidase, putative 0.0064 0.1243 0.8867
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0129 0.0614
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0183 0.0867
Trichomonas vaginalis sugar transporter, putative 0.0032 0.052 0.2465
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0129 0.0614
Schistosoma mansoni glucose transport protein 0.0103 0.2108 0.6032
Brugia malayi MH1 domain containing protein 0.0009 0.0005 0.001
Trypanosoma brucei glucose transporter, putative 0.0032 0.052 0.3709
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0129 0.0614
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0129 0.0614
Mycobacterium tuberculosis Conserved protein 0.0071 0.1401 0.1289
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0031 0.0511 0.0617
Echinococcus granulosus lysyl tRNA synthetase 0.0023 0.032 0.0915
Entamoeba histolytica hypothetical protein 0.0035 0.059 0.966
Loa Loa (eye worm) hypothetical protein 0.0071 0.1401 0.2744
Brugia malayi Cathepsin L-like precursor 0.0017 0.0183 0.0359
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0129 0.0614
Trypanosoma brucei glucose transporter, putative 0.0032 0.052 0.3709
Loa Loa (eye worm) hypothetical protein 0.0025 0.0367 0.0711
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0023 0.032 0.2281
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0183 0.0867
Trypanosoma brucei glucose transporter, putative 0.0032 0.052 0.3709
Plasmodium falciparum proline--tRNA ligase 0.0036 0.0611 0.0638
Mycobacterium tuberculosis Conserved protein 0.0071 0.1401 0.1289
Echinococcus granulosus geminin 0.0164 0.3495 1
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.1401 0.6648
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0129 0.0614
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0129 0.0614
Echinococcus granulosus smad 0.0016 0.0166 0.0475

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 29.0929 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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