TDR Targets

Basic information

Technical information

TDR Targets ID: 721275
Name: N-(3-chlorophenyl)-4-phenyl-1,3-thiazol-2-ami ne
MW: 286.779 | Formula: C15H11ClN2S
H donors: 1 H acceptors: 1 LogP: 5.12 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: Clc1cccc(c1)Nc1scc(n1)c1ccccc1
InChi: 1S/C15H11ClN2S/c16-12-7-4-8-13(9-12)17-15-18-14(10-19-15)11-5-2-1-3-6-11/h1-10H,(H,17,18)
InChiKey: IOSWOKMGZGLLLH-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-(3-chlorophenyl)-4-phenyl-thiazol-2-amine
N-(3-chlorophenyl)-4-phenyl-2-thiazolamine
(3-chlorophenyl)-(4-phenylthiazol-2-yl)amine
ZINC01122746

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0086	0.1169	0.4859
Plasmodium falciparum	glutathione reductase	0.0013	0.0103	0.0375
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0018	0.0171	0.06
Brugia malayi	alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase	0.001	0.0053	0.013
Echinococcus multilocularis	protein tyrosine phosphatase n9	0.0015	0.0128	0.0114
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0018	0.0171	0.0298
Echinococcus granulosus	thioredoxin glutathione reductase	0.0038	0.0471	0.0457
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.0186	0.2636	0.315
Onchocerca volvulus		0.0236	0.3384	1
Trypanosoma cruzi	phosphoglycerate kinase, putative	0.0062	0.0822	0.34
Leishmania major	hypothetical protein, conserved	0.0057	0.0752	0.3105
Plasmodium vivax	ataxin-2 like protein, putative	0.0025	0.0281	0.1122
Leishmania major	2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein	0.0013	0.0103	0.0375
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0013	0.0103	0.0375
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.0013	0.0103	0.0302
Plasmodium falciparum	thioredoxin reductase	0.0038	0.0463	0.189
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.0186	0.2636	0.315
Loa Loa (eye worm)	hypothetical protein	0.0169	0.2391	0.8057
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0128	0.0386
Trichomonas vaginalis	antibiotic synthetase, putative	0.0007	0.0014	0.0008
Onchocerca volvulus		0.0015	0.0128	0.0338
Brugia malayi	hypothetical protein	0.0016	0.015	0.0461
Echinococcus multilocularis	cpg binding protein	0.003	0.0354	0.0341
Schistosoma mansoni	protein tyrosine phosphatase	0.0015	0.0128	0.0114
Echinococcus multilocularis	receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type	0.0015	0.0128	0.0114
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0015	0.0128	0.0114
Chlamydia trachomatis	phosphoglycerate kinase	0.0169	0.2391	1
Echinococcus multilocularis	receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type	0.0015	0.0128	0.0114
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0015	0.0128	0.0386
Onchocerca volvulus		0.0015	0.0128	0.0338
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0017	0.0157	0.0658
Schistosoma mansoni	cpg binding protein	0.003	0.0354	0.0341
Onchocerca volvulus		0.0015	0.0128	0.0338
Mycobacterium tuberculosis	P-hydroxybenzoyl-AMP ligase FadD22	0.0007	0.0014	0.0059
Onchocerca volvulus		0.0015	0.0128	0.0338
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0024	0.0259	0.103
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0171	0.0533
Trypanosoma cruzi	trypanothione reductase, putative	0.0013	0.0103	0.0375
Trypanosoma cruzi	hypothetical protein, conserved	0.0057	0.0752	0.3105
Brugia malayi	hypothetical protein	0.0015	0.0128	0.0386
Onchocerca volvulus		0.0024	0.0259	0.0726
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0015	0.0128	0.0114
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0015	0.0128	0.0114
Onchocerca volvulus		0.0015	0.0128	0.0338
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0015	0.0128	0.0386
Loa Loa (eye worm)	dual specificity protein phosphatase CDC14B	0.0015	0.0128	0.0386
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0128	0.0386
Onchocerca volvulus		0.0015	0.0128	0.0338
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0018	0.0171	0.0717
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0091	0.1247	0.1235
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase	0.0013	0.0103	0.034
Trichomonas vaginalis	low molecular weight protein-tyrosine-phosphatase, putative	0.0186	0.2636	0.315
Mycobacterium tuberculosis	Probable phosphoglycerate kinase Pgk	0.0169	0.2391	1
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0024	0.0259	0.103
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0091	0.1247	0.1235
Onchocerca volvulus		0.0015	0.0128	0.0338
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0086	0.1169	0.4889
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0015	0.0128	0.0114
Onchocerca volvulus		0.0015	0.0128	0.0338
Loa Loa (eye worm)	protein-tyrosine-phosphatase	0.0015	0.0128	0.0386
Brugia malayi	Protein-tyrosine phosphatase	0.0015	0.0128	0.0386
Onchocerca volvulus		0.0015	0.0128	0.0338
Plasmodium vivax	glutathione reductase, putative	0.0038	0.0463	0.189
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0015	0.0128	0.0114
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0028	0.0331	0.1073
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0128	0.0386
Schistosoma mansoni	receptor protein tyrosine phosphatase n (ia2)	0.0015	0.0128	0.0114
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0015	0.0128	0.0386
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0281	0.0904
Trypanosoma cruzi	phosphoglycerate kinase, putative	0.0169	0.2391	1
Trypanosoma cruzi	tyrosine specific protein phosphatase, putative	0.0015	0.0128	0.0479
Onchocerca volvulus		0.0015	0.0128	0.0338
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.0015	0.0128	0.0137
Brugia malayi	Phosphoglycerate kinase	0.0062	0.0822	0.2739
Trichomonas vaginalis	set domain proteins, putative	0.0236	0.3384	0.4046
Treponema pallidum	phosphoglycerate kinase	0.0169	0.2391	1
Brugia malayi	Protein-tyrosine phosphatase	0.0015	0.0128	0.0386
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0128	0.0386
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0008	0.0032	0.0018
Giardia lamblia	Phosphoglycerate kinase	0.0169	0.2391	0.9031
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0013	0.0103	0.0375
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0015	0.0128	0.0386
Onchocerca volvulus		0.0015	0.0128	0.0338
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0024	0.0259	0.0934
Echinococcus multilocularis	microtubule associated protein 2	0.0687	1	1
Trypanosoma brucei	phosphoglycerate kinase	0.0169	0.2391	1
Brugia malayi	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein	0.001	0.0053	0.013
Loa Loa (eye worm)	protein-tyrosine phosphatase 1	0.0015	0.0128	0.0386
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.003	0.0358	0.0344
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0128	0.0386
Brugia malayi	F/Y-rich N-terminus family protein	0.001	0.0056	0.0143
Mycobacterium tuberculosis	Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase	0.0007	0.0014	0.0059
Brugia malayi	CXXC zinc finger family protein	0.0028	0.0331	0.1073
Mycobacterium tuberculosis	Probable reductase	0.0086	0.1169	0.4889
Plasmodium falciparum	ataxin-2 like protein, putative	0.0025	0.0281	0.1122
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase, LpdB	0.0013	0.0103	0.034
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0015	0.0128	0.0386
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0128	0.0386
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0128	0.0386
Plasmodium falciparum	dihydrolipoyl dehydrogenase, apicoplast	0.0013	0.0103	0.0375
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0024	0.0259	0.1083
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0128	0.0386
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0015	0.0128	0.0386
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0015	0.0128	0.0386
Echinococcus granulosus	histone lysine methyltransferase setb	0.003	0.0358	0.0344
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0015	0.0128	0.0114
Echinococcus multilocularis	receptor type tyrosine protein phosphatase zeta	0.0015	0.0128	0.0114
Brugia malayi	hypothetical protein	0.0025	0.0281	0.0904
Brugia malayi	Low molecular weight phosphotyrosine protein phosphatase containing protein	0.0186	0.2636	0.889
Brugia malayi	Thioredoxin reductase	0.0038	0.0463	0.1523
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0015	0.0128	0.0114
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.0015	0.0128	0.0137
Trypanosoma brucei	phosphoglycerate kinase	0.0169	0.2391	1
Leishmania major	phosphoglycerate kinase B, cytosolic	0.0169	0.2391	1
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0208	0.2964	1
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0128	0.0386
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0091	0.1247	0.1235
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.003	0.0358	0.0344
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.003	0.0358	0.0344
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.0057	0.0752	0.0892
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.0057	0.0752	0.0892
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0024	0.0259	0.0294
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0015	0.0128	0.0386
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.001	0.0058	0.0044
Mycobacterium tuberculosis	Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0007	0.0014	0.0059
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0091	0.1247	0.1235
Onchocerca volvulus		0.0015	0.0128	0.0338
Leishmania major	acetoin dehydrogenase e3 component-like protein	0.0013	0.0103	0.0375
Plasmodium falciparum	glutathione reductase	0.0038	0.0463	0.189
Toxoplasma gondii	NADPH-glutathione reductase	0.0013	0.0103	0.0375
Toxoplasma gondii	pyruvate dehydrogenase complex subunit PDH-E3II	0.0013	0.0103	0.0375
Trypanosoma brucei	low molecular weight protein tyrosine phosphatase, putative	0.0057	0.0752	0.3105
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0015	0.0128	0.0114
Mycobacterium tuberculosis	Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0007	0.0014	0.0059
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0015	0.0128	0.0386
Loa Loa (eye worm)	protein tyrosine phosphatase	0.0015	0.0128	0.0386
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0015	0.0128	0.0114
Echinococcus granulosus	receptor type tyrosine protein phosphatase zeta	0.0015	0.0128	0.0114
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0015	0.0128	0.0114
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0055	0.0721	0.2973
Plasmodium vivax	dihydrolipoyl dehydrogenase, apicoplast, putative	0.0013	0.0103	0.0375
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0015	0.0128	0.0386
Schistosoma mansoni	protein tyrosine phosphatase	0.0015	0.0128	0.0114
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0095	0.1309	0.5476
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0015	0.0128	0.0114
Mycobacterium ulcerans	phosphoglycerate kinase	0.0169	0.2391	0.9064
Entamoeba histolytica	dual specificity protein phosphatase, putative	0.0575	0.8354	1
Onchocerca volvulus		0.0015	0.0128	0.0338
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0015	0.0128	0.0386
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0013	0.0103	0.0375
Echinococcus granulosus	dihydrolipoamide dehydrogenase	0.0013	0.0103	0.0089
Brugia malayi	Protein-tyrosine phosphatase 1	0.0015	0.0128	0.0386
Echinococcus multilocularis	receptor type tyrosine protein phosphatase H	0.0015	0.0128	0.0114
Trichomonas vaginalis	phosphoglycerate kinase, putative	0.0169	0.2391	0.2856
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0013	0.0103	0.0375
Schistosoma mansoni	pcd6 interacting protein-related	0.0015	0.0128	0.0114
Toxoplasma gondii	phosphoglycerate kinase PGKII	0.0169	0.2391	1
Brugia malayi	hypothetical protein	0.0015	0.0128	0.0386
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0038	0.0471	0.0457
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0128	0.0386
Entamoeba histolytica	phosphoglycerate kinase, putative	0.0169	0.2391	0.285
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.0281	0.1122
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.0186	0.2636	0.3144
Brugia malayi	Dual specificity protein phosphatase CDC14B	0.0015	0.0128	0.0386
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0128	0.0386
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0126	0.1763	0.593
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0126	0.1763	0.1752
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0015	0.0128	0.0386
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0013	0.0103	0.0375
Toxoplasma gondii	thioredoxin reductase	0.0038	0.0463	0.189
Onchocerca volvulus		0.0186	0.2636	0.7781
Loa Loa (eye worm)	hypothetical protein	0.003	0.0358	0.1165
Mycobacterium tuberculosis	Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot	0.0013	0.0103	0.0432
Echinococcus granulosus	Receptor type tyrosine protein phosphatase O	0.0015	0.0128	0.0114
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0095	0.1309	0.5449
Schistosoma mansoni	protein-tyrosine phosphatase n9	0.0015	0.0128	0.0114
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0.0259	0.0934
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0015	0.0128	0.0386
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0038	0.0463	0.1938
Brugia malayi	Pre-SET motif family protein	0.003	0.0358	0.1165
Plasmodium falciparum	ataxin-2 like protein, putative	0.0025	0.0281	0.1122
Schistosoma mansoni	microtubule-associated protein tau	0.0687	1	1
Trypanosoma brucei	dihydrolipoyl dehydrogenase	0.0013	0.0103	0.0375
Trichomonas vaginalis	phosphoglycerate kinase, putative	0.0169	0.2391	0.2856
Echinococcus multilocularis		0.0015	0.0128	0.0114
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0015	0.0128	0.0114
Mycobacterium tuberculosis	Probable dehydrogenase	0.0086	0.1169	0.4889
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0091	0.1247	0.1235
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0015	0.0128	0.0386
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0015	0.0128	0.0114
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0015	0.0128	0.0386
Mycobacterium ulcerans	phosphotyrosine protein phosphatase PtpA	0.0186	0.2636	1
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0015	0.0128	0.0386
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0171	0.0533
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0015	0.0128	0.0114
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0015	0.0128	0.0114
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0017	0.0157	0.0658
Onchocerca volvulus	4.1 G protein, putative homolog	0.0015	0.0128	0.0338
Trypanosoma cruzi	tyrosine specific protein phosphatase, putative	0.0015	0.0128	0.0479
Mycobacterium tuberculosis	Probable peptide synthetase Nrp (peptide synthase)	0.0007	0.0014	0.0059
Trichomonas vaginalis	antibiotic synthetase, putative	0.0007	0.0014	0.0008
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0015	0.0128	0.0386
Trypanosoma cruzi	hypothetical protein, conserved	0.0057	0.0752	0.3105
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0015	0.0128	0.0114
Schistosoma mansoni	hypothetical protein	0.0406	0.5869	0.5863
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0015	0.0128	0.0114
Loa Loa (eye worm)	histone methyltransferase	0.001	0.0058	0.0148
Echinococcus multilocularis	phosphoglycerate kinase 1	0.0169	0.2391	0.238
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0024	0.0259	0.0934
Brugia malayi	hypothetical protein	0.0015	0.0128	0.0386
Onchocerca volvulus		0.0015	0.0128	0.0338
Plasmodium falciparum	phosphoglycerate kinase	0.0169	0.2391	1
Trypanosoma brucei	dihydrolipoamide dehydrogenase, point mutation	0.0013	0.0103	0.0375
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0126	0.1763	0.1752
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0024	0.0259	0.0934
Schistosoma mansoni	non-receptor protein-tyrosine phosphatase	0.0015	0.0128	0.0114
Mycobacterium tuberculosis	Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase)	0.0128	0.1797	0.7515
Trypanosoma cruzi	PAS-domain containing phosphoglycerate kinase, putative	0.0062	0.0822	0.34
Entamoeba histolytica	acyl-coA synthetase, putative	0.0024	0.0259	0.0294
Mycobacterium tuberculosis	Phenyloxazoline synthase MbtB (phenyloxazoline synthetase)	0.0007	0.0014	0.0059
Onchocerca volvulus		0.0015	0.0128	0.0338
Brugia malayi	AMP-binding enzyme family protein	0.0024	0.0259	0.083
Trichomonas vaginalis	mercuric reductase, putative	0.0013	0.0103	0.0115
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0015	0.0128	0.0386
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0128	0.0386
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0015	0.0128	0.0386
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0128	0.0386
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0091	0.1247	0.1235
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0013	0.0103	0.0375
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0128	0.0386
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0259	0.083
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0015	0.0128	0.0386
Onchocerca volvulus		0.0015	0.0128	0.0338
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0128	0.0386
Leishmania major	4-coumarate:coa ligase-like protein	0.0024	0.0259	0.103
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.0186	0.2636	0.3144
Leishmania major	PAS-domain containing phosphoglycerate kinase, putative	0.0062	0.0822	0.34
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0091	0.1247	0.1235
Echinococcus multilocularis	mixed lineage leukemia protein mll	0.0008	0.0032	0.0018
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0259	0.083
Trypanosoma brucei	PAB1-binding protein , putative	0.0025	0.0281	0.1122
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0015	0.0128	0.0386
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0128	0.0386
Mycobacterium leprae	Probable phosphoglycerate kinase Pgk	0.0169	0.2391	1
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0091	0.1247	0.418
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0015	0.0128	0.0114
Brugia malayi	Phosphoglycerate kinase	0.0169	0.2391	0.8057
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0015	0.0128	0.0114
Schistosoma mansoni	receptor protein tyrosine phosphatase n (ia2)	0.0015	0.0128	0.0114
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.0186	0.2636	0.315
Plasmodium vivax	thioredoxin reductase, putative	0.0038	0.0463	0.189
Trypanosoma cruzi	trypanothione reductase, putative	0.0038	0.0463	0.189
Onchocerca volvulus		0.0015	0.0128	0.0338
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0091	0.1247	0.418
Leishmania major	hypothetical protein, conserved	0.0025	0.0281	0.1122
Plasmodium vivax	acyl-CoA synthetase, putative	0.0018	0.0171	0.0661
Leishmania major	phosphoglycerate kinase C, glycosomal	0.0169	0.2391	1
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0015	0.0128	0.0114
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0095	0.1309	0.5476
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0013	0.0103	0.0375
Plasmodium vivax	dihydrolipoyl dehydrogenase, mitochondrial, putative	0.0013	0.0103	0.0375
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0015	0.0128	0.0386
Trichomonas vaginalis	low molecular weight protein-tyrosine-phosphatase, putative	0.0186	0.2636	0.315
Loa Loa (eye worm)	glutathione reductase	0.0038	0.0463	0.1523
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0015	0.0128	0.0386
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0015	0.0128	0.0386
Echinococcus granulosus	phosphoglycerate kinase 1	0.0169	0.2391	0.238
Schistosoma mansoni	receptor protein tyrosine phosphatase r (pcptp1)	0.0015	0.0128	0.0114
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0015	0.0128	0.0386
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0128	0.0386
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0013	0.0103	0.0375
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0015	0.0128	0.0114
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0259	0.083
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0017	0.0157	0.0658
Schistosoma mansoni	protein tyrosine phosphatase non-receptor type nt1	0.0015	0.0128	0.0114
Mycobacterium ulcerans	flavoprotein disulfide reductase	0.0013	0.0103	0.034
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0015	0.0128	0.0386
Trichomonas vaginalis	glutathione reductase, putative	0.0013	0.0103	0.0115
Echinococcus multilocularis	dnaJ subfamily B	0.0406	0.5869	0.5863
Leishmania major	tyrosine specific protein phosphatase, putative	0.0015	0.0128	0.0479
Echinococcus multilocularis	hypothetical protein	0.0015	0.0128	0.0114
Schistosoma mansoni	rgs-gaip interacting protein gipc	0.0015	0.0128	0.0114
Trichomonas vaginalis	pps1 dual specificty phosphatase, putative	0.0575	0.8354	1
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0128	0.0386
Mycobacterium tuberculosis	Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0007	0.0014	0.0059
Brugia malayi	Pre-SET motif family protein	0.0208	0.2964	1
Giardia lamblia	Protein tyrosine phosphatase	0.0015	0.0128	0.0098
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.0281	0.1122
Echinococcus granulosus	receptor type tyrosine protein phosphatase zeta	0.0015	0.0128	0.0114
Schistosoma mansoni	cpg binding protein	0.0028	0.0331	0.0317
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0015	0.0128	0.0114
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.003	0.0358	0.1446
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0013	0.0103	0.0375
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0126	0.1763	0.1752
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0015	0.0128	0.0386
Leishmania major	4-coumarate:coa ligase-like protein	0.0024	0.0259	0.103
Trypanosoma cruzi	phosphoglycerate kinase, putative	0.0169	0.2391	1
Mycobacterium tuberculosis	Peptide synthetase MbtE (peptide synthase)	0.0007	0.0014	0.0059
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0.0259	0.0934
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0126	0.1763	0.1752
Mycobacterium tuberculosis	Probable oxidoreductase	0.0095	0.1309	0.5476
Brugia malayi	glutathione reductase	0.0038	0.0463	0.1523
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.0011	0.0078	0.0064
Brugia malayi	AMP-binding enzyme family protein	0.0024	0.0259	0.083
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0013	0.0103	0.0375
Schistosoma mansoni	protein-tyrosine phosphatase non-receptor type nt5	0.0015	0.0128	0.0114
Schistosoma mansoni	hypothetical protein	0.0011	0.0078	0.0064
Plasmodium falciparum	thioredoxin reductase	0.0013	0.0103	0.0375
Brugia malayi	hypothetical protein	0.0015	0.0128	0.0386
Echinococcus multilocularis	dihydrolipoamide dehydrogenase	0.0013	0.0103	0.0089
Leishmania major	4-coumarate:coa ligase-like protein	0.0024	0.0259	0.103
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0171	0.0533
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0171	0.0533
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0007	0.0014	0.0059
Schistosoma mansoni	phosphoglycerate kinase	0.0169	0.2391	0.238
Plasmodium falciparum	dihydrolipoyl dehydrogenase, mitochondrial	0.0013	0.0103	0.0375
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0015	0.0128	0.0386
Onchocerca volvulus		0.0015	0.0128	0.0338
Trypanosoma brucei	trypanothione reductase	0.0038	0.0463	0.189
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0128	0.0386
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0024	0.0259	0.1083
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.003	0.0358	0.0344
Mycobacterium tuberculosis	Peptide synthetase MbtF (peptide synthase)	0.0007	0.0014	0.0059
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0015	0.0128	0.0114
Mycobacterium tuberculosis	Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase)	0.0007	0.0014	0.0059
Schistosoma mansoni	cpg binding protein	0.003	0.0354	0.0341
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0015	0.0128	0.0386
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0015	0.0128	0.0386
Entamoeba histolytica	Pten 3-phosphoinositide phosphatase, putative	0.0015	0.0128	0.0137
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0017	0.0157	0.0658
Trypanosoma brucei	phosphoglycerate kinase, putative	0.0062	0.0822	0.34
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0128	0.0386
Echinococcus granulosus	dnaJ subfamily B	0.0406	0.5869	0.5863
Schistosoma mansoni	phosphoglycerate kinase	0.0169	0.2391	0.238
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0013	0.0103	0.0375
Mycobacterium ulcerans	hypothetical protein	0.0024	0.0259	0.0934
Brugia malayi	AMP-binding enzyme family protein	0.0024	0.0259	0.083
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0128	0.0386
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0008	0.0032	0.0018
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0015	0.0128	0.0386
Loa Loa (eye worm)	phosphotyrosine protein phosphatase	0.0186	0.2636	0.889
Toxoplasma gondii	LsmAD domain-containing protein	0.0025	0.0281	0.1122
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0128	0.0386
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0015	0.0128	0.0114
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0128	0.0386
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0013	0.0103	0.0375
Echinococcus multilocularis	receptor type tyrosine protein phosphatase F	0.0015	0.0128	0.0114
Onchocerca volvulus		0.0015	0.0128	0.0338
Trypanosoma cruzi	tyrosine specific protein phosphatase, putative	0.0015	0.0128	0.0479
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0015	0.0128	0.0114
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0015	0.0128	0.0114
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0128	0.0386
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0.0259	0.0934
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0128	0.0386
Leishmania major	trypanothione reductase	0.0038	0.0463	0.189
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0024	0.0259	0.0934
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0015	0.0128	0.0386
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0015	0.0128	0.0114
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0128	0.0386
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0015	0.0128	0.0114
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0008	0.0032	0.0018
Schistosoma mansoni	protein tyrosine phosphatase	0.0015	0.0128	0.0114
Onchocerca volvulus		0.0015	0.0128	0.0338
Plasmodium falciparum	acyl-CoA synthetase	0.0018	0.0171	0.0661
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0062	0.0816	0.0803
Onchocerca volvulus		0.0028	0.0331	0.0939
Brugia malayi	hypothetical protein	0.0015	0.0128	0.0386
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0015	0.0128	0.0114
Trichomonas vaginalis	pten, drome, putative	0.0015	0.0128	0.0145
Onchocerca volvulus		0.003	0.0358	0.102
Trypanosoma brucei	phosphoglycerate kinase	0.0062	0.0822	0.34
Trichomonas vaginalis	low molecular weight protein-tyrosine-phosphatase, putative	0.0186	0.2636	0.315
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0029	0.0333	0.0319
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0015	0.0128	0.0386
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.003	0.0358	0.0344
Onchocerca volvulus		0.0015	0.0128	0.0338
Toxoplasma gondii	phosphoglycerate kinase PGKI	0.0169	0.2391	1
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0086	0.1169	0.4889
Loa Loa (eye worm)	thioredoxin reductase	0.0038	0.0463	0.1523
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0086	0.1169	0.4889
Schistosoma mansoni	receptor protein tyrosine phosphatase	0.0015	0.0128	0.0114
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0086	0.1169	0.4889
Plasmodium vivax	phosphoglycerate kinase, putative	0.0169	0.2391	1
Giardia lamblia	Low molecular weight protein-tyrosine-phosphatase	0.0186	0.2636	1
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0126	0.1763	0.1752
Echinococcus granulosus	protein tyrosine phosphatase n9	0.0015	0.0128	0.0114
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.001	0.0058	0.0044
Echinococcus granulosus	cpg binding protein	0.003	0.0354	0.0341
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0015	0.0128	0.0386
Brugia malayi	protein-tyrosine phosphatase Lar-like precursor, putative	0.0015	0.0128	0.0386
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0171	0.0533
Loa Loa (eye worm)	fibronectin type III domain-containing protein	0.0015	0.0128	0.0386
Trypanosoma cruzi	3-phosphoglycerate kinase, glycosomal	0.0062	0.0822	0.34
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0024	0.0259	0.0294
Trypanosoma brucei	protein tyrosine phosphatase 1	0.0015	0.0128	0.0479
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0126	0.1763	0.593
Plasmodium vivax	SET domain protein, putative	0.003	0.0358	0.1446
Echinococcus granulosus	Receptor type tyrosine protein phosphatase O	0.0015	0.0128	0.0114
Echinococcus multilocularis	receptor type tyrosine protein phosphatase zeta	0.0015	0.0128	0.0114
Onchocerca volvulus		0.0015	0.0128	0.0338
Schistosoma mansoni	dihydrolipoamide dehydrogenase	0.0013	0.0103	0.0089
Echinococcus granulosus	mixed lineage leukemia protein mll	0.0008	0.0032	0.0018
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0015	0.0128	0.0114
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.0011	0.0078	0.0064
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.003	0.0358	0.0344
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0015	0.0128	0.0386
Onchocerca volvulus		0.0015	0.0128	0.0338
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0015	0.0128	0.0386
Trypanosoma cruzi	phosphoglycerate kinase, putative	0.0062	0.0822	0.34
Leishmania major	protein-tyrosine phosphatase 1-like protein	0.0015	0.0128	0.0479
Trypanosoma cruzi	PAS-domain containing phosphoglycerate kinase, putative	0.0062	0.0822	0.34
Wolbachia endosymbiont of Brugia malayi	phosphoglycerate kinase	0.0169	0.2391	1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 721275