Detailed information for compound 725092

Basic information

Technical information
  • TDR Targets ID: 725092
  • Name: N-(2,4-dimethylphenyl)-2-[(2-methoxy-5-methyl phenyl)sulfonyl-methylamino]acetamide
  • MW: 376.47 | Formula: C19H24N2O4S
  • H donors: 1 H acceptors: 3 LogP: 3.04 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1S(=O)(=O)N(CC(=O)Nc1ccc(cc1C)C)C)C
  • InChi: 1S/C19H24N2O4S/c1-13-6-8-16(15(3)10-13)20-19(22)12-21(4)26(23,24)18-11-14(2)7-9-17(18)25-5/h6-11H,12H2,1-5H3,(H,20,22)
  • InChiKey: IXBGCGLPMNCPSY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(2,4-dimethylphenyl)-2-[(2-methoxy-5-methyl-phenyl)sulfonyl-methyl-amino]acetamide
  • N-(2,4-dimethylphenyl)-2-[(2-methoxy-5-methyl-phenyl)sulfonyl-methyl-amino]ethanamide
  • ZINC04840550

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis pyruvate kinase, putative 0.0022 0.0294 0.0586
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0042 0.0616 0.844
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0007 0.004 0.0083
Echinococcus granulosus dnaJ subfamily B 0.0397 0.6522 0.6514
Echinococcus multilocularis importin 5 0.0011 0.01 0.0076
Brugia malayi beta-lactamase 0.0036 0.0528 0.1096
Trichomonas vaginalis hypothetical protein 0.0011 0.01 0.0165
Brugia malayi CXXC zinc finger family protein 0.0028 0.0385 0.08
Loa Loa (eye worm) hypothetical protein 0.0007 0.004 0.004
Schistosoma mansoni hypothetical protein 0.0006 0.0024 0.0014
Brugia malayi hypothetical protein 0.0156 0.251 0.5216
Loa Loa (eye worm) pyruvate kinase-PB 0.0016 0.0181 0.0181
Loa Loa (eye worm) hypothetical protein 0.0006 0.0024 0.0024
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0528 0.5984
Mycobacterium ulcerans beta-lactamase 0.0036 0.0528 1
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0036 0.0521 0.7169
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0007 0.004 0.0016
Echinococcus granulosus muscleblind protein 0.0294 0.4812 0.48
Brugia malayi photoreceptor-specific nuclear receptor 0.0007 0.004 0.0083
Schistosoma mansoni pyruvate kinase 0.0022 0.0294 0.0285
Echinococcus multilocularis pyruvate kinase 0.0012 0.0113 0.0089
Loa Loa (eye worm) hypothetical protein 0.0036 0.0528 0.0528
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0055 0.0832 0.1728
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0525 0.0515
Onchocerca volvulus 0.0049 0.074 0.1552
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0026 0.0006
Schistosoma mansoni survival motor neuron protein 0.0032 0.0449 0.044
Brugia malayi von Willebrand factor type A domain containing protein 0.0006 0.0024 0.005
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0026 0.0006
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0007 0.004 0.0083
Loa Loa (eye worm) von Willebrand factor type A domain-containing protein 0.0006 0.0024 0.0024
Trichomonas vaginalis helicase, putative 0.0006 0.0026 0.0006
Loa Loa (eye worm) hypothetical protein 0.0007 0.004 0.004
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0528 1
Schistosoma mansoni hypothetical protein 0.0032 0.0449 0.044
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0032 0.0449 0.0934
Brugia malayi hypothetical protein 0.0006 0.0024 0.005
Echinococcus multilocularis geminin 0.0169 0.2732 0.2715
Schistosoma mansoni RAR-like nuclear receptor 0.0007 0.004 0.003
Plasmodium vivax pyruvate kinase, putative 0.0022 0.0294 0.3211
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0528 0.1092
Schistosoma mansoni aldehyde dehydrogenase 0.0036 0.0521 0.0512
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0007 0.004 0.0083
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0528 0.0505
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0042 0.0616 0.7038
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0233 0.3794 1
Onchocerca volvulus 0.0036 0.0528 0.1092
Schistosoma mansoni dihydropyridine-sensitive l-type calcium channel 0.0145 0.2328 0.232
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0046 0.0687 0.1438
Mycobacterium ulcerans hypothetical protein 0.0036 0.0528 1
Schistosoma mansoni thyroid hormone receptor 0.0007 0.004 0.003
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0036 0.0525 0.0502
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0234 0.3164
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0006 0.0024 0.005
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.068 0.0671
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.068 0.0658
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0008 0.0058 0.0049
Loa Loa (eye worm) steroid hormone receptor 0.0007 0.004 0.004
Loa Loa (eye worm) hypothetical protein 0.0057 0.0866 0.0866
Echinococcus multilocularis voltage dependent calcium channel subunit 0.0151 0.243 0.2412
Treponema pallidum methyl-accepting chemotaxis protein (mcp2-1) 0.0307 0.503 1
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0085 0.0176
Mycobacterium ulcerans aldehyde dehydrogenase 0.0036 0.0521 0.9807
Loa Loa (eye worm) CUTiclin family member 0.0006 0.0024 0.0024
Echinococcus multilocularis pyruvate kinase 0.0012 0.0113 0.0089
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0042 0.0616 0.0594
Leishmania major hypothetical protein, conserved 0.0036 0.0528 0.7284
Schistosoma mansoni cpg binding protein 0.0028 0.0385 0.0376
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0528 0.1092
Echinococcus multilocularis transportin 1 0.0011 0.01 0.0076
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0007 0.004 0.0083
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0007 0.004 0.0083
Echinococcus granulosus importin subunit beta 1 0.0057 0.0866 0.0844
Brugia malayi beta-lactamase family protein 0.0036 0.0528 0.1096
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0022 0.0294 0.0323
Brugia malayi Zona pellucida-like domain containing protein 0.0006 0.0024 0.005
Brugia malayi steroid hormone receptor 0.0007 0.004 0.0083
Loa Loa (eye worm) hypothetical protein 0.0006 0.0024 0.0024
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0026 0.0006
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0007 0.004 0.003
Leishmania major GTP-binding protein, putative 0.0042 0.0616 0.8795
Schistosoma mansoni ran 0.0042 0.0616 0.0607
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0926 0.0917
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0015 0.0177 0.0307
Onchocerca volvulus 0.0007 0.004 0.0034
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0007 0.004 0.004
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0015 0.0177 0.1824
Brugia malayi von Willebrand factor type A domain containing protein 0.0006 0.0024 0.005
Loa Loa (eye worm) hypothetical protein 0.0016 0.0181 0.0181
Schistosoma mansoni thyroid hormone receptor 0.0007 0.004 0.003
Giardia lamblia Pyruvate kinase 0.0022 0.0294 0.3602
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0528 1
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0007 0.004 0.0083
Loa Loa (eye worm) pyruvate kinase 0.0022 0.0294 0.0294
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0525 0.0515
Echinococcus multilocularis pyruvate kinase 0.0022 0.0294 0.0271
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.0007 0.0034 0.0071
Schistosoma mansoni aldehyde dehydrogenase 0.0036 0.0521 0.0512
Plasmodium falciparum pyruvate kinase 2 0.0012 0.0113 0.1056
Echinococcus granulosus transportin 1 0.0011 0.01 0.0076
Loa Loa (eye worm) pyruvate kinase 0.0022 0.0294 0.0294
Echinococcus granulosus pyruvate kinase 0.0012 0.0113 0.0089
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0007 0.004 0.004
Echinococcus multilocularis cpg binding protein 0.0029 0.0411 0.0388
Schistosoma mansoni ran 0.0042 0.0616 0.0607
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0026 0.0006
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0007 0.004 0.0083
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0036 0.0521 0.0498
Echinococcus multilocularis translational activator gcn1 0.0011 0.01 0.0076
Mycobacterium tuberculosis Conserved protein 0.0036 0.0528 0.0968
Echinococcus granulosus FTZ F1 alpha 0.0007 0.004 0.0016
Echinococcus multilocularis pyruvate kinase 0.0012 0.0113 0.0089
Onchocerca volvulus Pyruvate kinase homolog 0.0022 0.0294 0.0586
Echinococcus multilocularis muscleblind protein 0.0294 0.4812 0.48
Mycobacterium ulcerans lipase LipD 0.0036 0.0528 1
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0042 0.0616 0.7038
Trichomonas vaginalis importin beta-1, putative 0.0046 0.0687 0.1438
Loa Loa (eye worm) beta-lactamase 0.0036 0.0528 0.0528
Loa Loa (eye worm) hypothetical protein 0.0036 0.0528 0.0528
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0026 0.0006
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.068 0.1413
Toxoplasma gondii pyruvate kinase PyKII 0.0012 0.0113 0.1056
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0008 0.0058 0.0035
Schistosoma mansoni hypothetical protein 0.0169 0.2732 0.2725
Echinococcus granulosus geminin 0.0169 0.2732 0.2715
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0007 0.004 0.0016
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0007 0.004 0.0016
Loa Loa (eye worm) hypothetical protein 0.0006 0.0024 0.0024
Toxoplasma gondii HEAT repeat-containing protein 0.0057 0.0866 1
Toxoplasma gondii HEAT repeat-containing protein 0.0011 0.01 0.0904
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0007 0.004 0.0016
Brugia malayi RNA, U transporter 1 0.0161 0.2606 0.5416
Loa Loa (eye worm) hypothetical protein 0.0036 0.0528 0.0528
Entamoeba histolytica HEAT repeat domain containing protein 0.0011 0.01 0.1148
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.0525 0.5948
Plasmodium falciparum importin beta, putative 0.0057 0.0866 1
Loa Loa (eye worm) hypothetical protein 0.0006 0.0024 0.0024
Onchocerca volvulus 0.0055 0.0832 0.1751
Onchocerca volvulus 0.0036 0.0528 0.1092
Trichomonas vaginalis ran, putative 0.0042 0.0616 0.1284
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0234 0.1607
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0026 0.0006
Toxoplasma gondii ABC1 family protein 0.0036 0.0528 0.5984
Trypanosoma brucei pyruvate kinase 1 0.0022 0.0294 0.2536
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0234 0.0156
Entamoeba histolytica hypothetical protein 0.0046 0.0687 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.0007 0.004 0.003
Loa Loa (eye worm) hypothetical protein 0.0006 0.0024 0.0024
Loa Loa (eye worm) histone methyltransferase 0.001 0.0087 0.0087
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0234 1
Plasmodium vivax transportin, putative 0.0011 0.01 0.0904
Brugia malayi Pre-SET motif family protein 0.0036 0.0525 0.109
Echinococcus multilocularis dnaJ subfamily B 0.0397 0.6522 0.6514
Schistosoma mansoni retinoic acid receptor RXR 0.0007 0.004 0.003
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0234 0.2493
Loa Loa (eye worm) hypothetical protein 0.0006 0.0024 0.0024
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0026 0.0006
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0234 0.2278
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.046 0.7577 0.7571
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0528 0.0968
Echinococcus granulosus voltage dependent calcium channel subunit 0.0332 0.5438 0.5427
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0007 0.004 0.004
Brugia malayi beta-lactamase family protein 0.0036 0.0528 0.1096
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0007 0.004 0.004
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0055 0.0832 0.0823
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0528 0.0968
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0007 0.004 0.003
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0026 0.0006
Trichomonas vaginalis esterase, putative 0.0036 0.0528 0.1092
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0007 0.004 0.0034
Echinococcus granulosus survival motor neuron protein 1 0.0156 0.251 0.2492
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.068 0.0658
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0528 0.0968
Echinococcus granulosus histone lysine methyltransferase setb 0.0036 0.0525 0.0502
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0007 0.004 0.0016
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0249 0.4065 0.4065
Plasmodium falciparum pyruvate kinase 0.0022 0.0294 0.3211
Brugia malayi Pyruvate kinase, muscle isozyme 0.0022 0.0294 0.0611
Loa Loa (eye worm) hypothetical protein 0.0036 0.0528 0.0528
Schistosoma mansoni cpg binding protein 0.0029 0.0411 0.0402
Brugia malayi follicle stimulating hormone receptor 0.0231 0.3763 0.782
Echinococcus granulosus pyruvate kinase 0.0012 0.0113 0.0089
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0006 0.0026 0.0006
Loa Loa (eye worm) hypothetical protein 0.0006 0.0024 0.0024
Echinococcus multilocularis L aminoadipate semialdehyde 0.0055 0.0832 0.081
Onchocerca volvulus 0.0284 0.4637 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0007 0.004 0.0016
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0036 0.0521 0.0498
Schistosoma mansoni hypothetical protein 0.0078 0.1217 0.1209
Brugia malayi Nuclear hormone receptor-like 1 0.0007 0.004 0.0083
Echinococcus granulosus ecdysone induced protein 78C 0.0007 0.004 0.0016
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0007 0.004 0.0016
Plasmodium vivax SET domain protein, putative 0.0036 0.0525 0.5948
Trypanosoma brucei pyruvate kinase 1, putative 0.0022 0.0294 0.2536
Loa Loa (eye worm) importin-beta domain-containing protein 0.0011 0.01 0.01
Loa Loa (eye worm) hypothetical protein 0.0006 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0007 0.004 0.004
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0007 0.004 0.004
Brugia malayi ecdysteroid receptor 0.0007 0.004 0.0083
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0026 0.0006
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0234 0.0419
Echinococcus granulosus GTP binding nuclear protein Ran 0.0042 0.0616 0.0594
Loa Loa (eye worm) hypothetical protein 0.0007 0.004 0.004
Brugia malayi von Willebrand Factor 0.0006 0.0024 0.005
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0234 0.0234
Echinococcus granulosus pyruvate kinase 0.0022 0.0294 0.0271
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0007 0.004 0.0083
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.0525 0.0502
Onchocerca volvulus Bile acid receptor homolog 0.0007 0.004 0.0034
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0008 0.0058 0.0035
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.0821 0.9475
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0006 0.0026 0.0006
Brugia malayi von Willebrand factor type A domain containing protein 0.0006 0.0024 0.005
Echinococcus multilocularis FTZ F1 alpha 0.0007 0.004 0.0016
Loa Loa (eye worm) hypothetical protein 0.0156 0.251 0.251
Loa Loa (eye worm) hypothetical protein 0.0007 0.004 0.004
Echinococcus multilocularis snurportin 1 0.0606 1 1
Echinococcus granulosus pyruvate kinase 0.0022 0.0294 0.0271
Schistosoma mansoni ap endonuclease 0.0019 0.0234 0.0224
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0026 0.0006
Schistosoma mansoni coup transcription factor 0.0007 0.004 0.003
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0087 0.0063
Brugia malayi Importin beta-1 subunit 0.0057 0.0866 0.1799
Echinococcus granulosus voltage dependent calcium channel subunit 0.0151 0.243 0.2412
Echinococcus multilocularis ecdysone induced protein 78C 0.0007 0.004 0.0016
Brugia malayi Immunoglobulin I-set domain containing protein 0.0006 0.0024 0.005
Echinococcus multilocularis survival motor neuron protein 1 0.0156 0.251 0.2492
Echinococcus multilocularis voltage dependent calcium channel subunit 0.0332 0.5438 0.5427
Brugia malayi Steroid receptor seven-up type 2 0.0007 0.004 0.0083
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0007 0.004 0.003
Schistosoma mansoni importin beta-1 0.0057 0.0866 0.0857
Schistosoma mansoni ap endonuclease 0.0019 0.0234 0.0224
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.068 0.0671
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0528 1
Onchocerca volvulus 0.0036 0.0525 0.1085
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0042 0.0616 0.844
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0528 0.6483
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0042 0.0616 0.7038
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0046 0.0687 0.1438
Schistosoma mansoni nuclear hormone receptor 0.0007 0.004 0.003
Schistosoma mansoni hypothetical protein 0.0006 0.0024 0.0014
Onchocerca volvulus Pyruvate kinase homolog 0.0022 0.0294 0.0586
Brugia malayi von Willebrand factor type A domain containing protein 0.0006 0.0024 0.005
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0528 0.6483
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0026 0.0006
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0026 0.0006
Echinococcus multilocularis importin subunit beta 1 0.0057 0.0866 0.0844
Loa Loa (eye worm) hypothetical protein 0.0006 0.0024 0.0024
Schistosoma mansoni hypothetical protein 0.0606 1 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.068 0.0658
Mycobacterium leprae Probable pyruvate kinase PykA 0.0022 0.0294 0.3333
Trypanosoma cruzi pyruvate kinase 2, putative 0.0022 0.0294 0.1333
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.068 0.0658
Echinococcus granulosus mixed lineage leukemia protein mll 0.0008 0.0058 0.0035
Toxoplasma gondii HEAT repeat-containing protein 0.0011 0.01 0.0904
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0007 0.004 0.0083
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0007 0.004 0.0016
Schistosoma mansoni cpg binding protein 0.0029 0.0411 0.0402
Loa Loa (eye worm) hypothetical protein 0.0006 0.0024 0.0024
Chlamydia trachomatis pyruvate kinase 0.0022 0.0294 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0234 0.021
Brugia malayi Muscleblind-like protein 0.0294 0.4812 1
Entamoeba histolytica pyruvate kinase, putative 0.0016 0.0181 0.2375
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0007 0.004 0.003
Echinococcus multilocularis pyruvate kinase 0.0018 0.0216 0.0192
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0042 0.0616 0.1281
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0007 0.004 0.004
Schistosoma mansoni hypothetical protein 0.0397 0.6522 0.6519
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0007 0.004 0.0083
Mycobacterium tuberculosis Conserved protein 0.0036 0.0528 0.0968
Echinococcus granulosus importin 5 0.0011 0.01 0.0076
Plasmodium vivax importin-beta 2, putative 0.0057 0.0866 1
Echinococcus multilocularis muscleblind protein 1 0.0294 0.4812 0.48
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0007 0.004 0.0016
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0528 0.0968
Echinococcus granulosus translational activator gcn1 0.0011 0.01 0.0076
Brugia malayi von Willebrand factor type A domain containing protein 0.0006 0.0024 0.005
Schistosoma mansoni pyruvate kinase 0.0022 0.0294 0.0285
Loa Loa (eye worm) hypothetical protein 0.0055 0.0832 0.0832
Echinococcus granulosus L aminoadipate semialdehyde 0.0055 0.0832 0.081
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0525 0.0515
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0528 0.1092
Loa Loa (eye worm) hypothetical protein 0.0294 0.4812 0.4812
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0007 0.004 0.004
Loa Loa (eye worm) von Willebrand factor domain-containing protein 0.0006 0.0024 0.0024
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0528 0.0528
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0007 0.004 0.0083
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0007 0.004 0.0016
Loa Loa (eye worm) hypothetical protein 0.0049 0.074 0.074
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0528 0.0968
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0036 0.0521 0.0949
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0528 0.0518
Mycobacterium tuberculosis Conserved protein 0.0036 0.0528 0.0968
Leishmania major pyruvate kinase 0.0022 0.0294 0.3307
Leishmania major phosphopantetheinyl transferase-like protein 0.0015 0.0177 0.1319
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0034 0.0493 0.047
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0015 0.0177 0.1824
Loa Loa (eye worm) hypothetical protein 0.0006 0.0024 0.0024
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0385 0.0385
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0234 0.0455
Trypanosoma brucei hypothetical protein, conserved 0.0015 0.0177 0.1012
Plasmodium vivax pyruvate kinase 2, putative 0.0012 0.0113 0.1056
Brugia malayi nuclear receptor NHR-88 0.0007 0.004 0.0083
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0007 0.004 0.0016
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0042 0.0616 1
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0528 0.5585
Brugia malayi Zona pellucida-like domain containing protein 0.0006 0.0024 0.005
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.074 0.0731
Echinococcus granulosus cpg binding protein 0.0029 0.0411 0.0388
Brugia malayi Pre-SET motif family protein 0.0249 0.4065 0.8448
Schistosoma mansoni pyruvate kinase 0.0012 0.0113 0.0103
Mycobacterium ulcerans pyruvate kinase 0.0022 0.0294 0.3333
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0234 0.0455
Brugia malayi Cache domain containing protein 0.0067 0.1032 0.2145
Onchocerca volvulus 0.0036 0.0528 0.1092
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.068 0.068
Echinococcus granulosus pyruvate kinase 0.0012 0.0113 0.0089
Leishmania major importin beta-1 subunit, putative 0.0046 0.0687 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0026 0.0006
Trypanosoma cruzi importin beta-1 subunit, putative 0.0046 0.0687 1
Loa Loa (eye worm) hypothetical protein 0.0006 0.0024 0.0024
Onchocerca volvulus 0.0032 0.0449 0.0923
Toxoplasma gondii pyruvate kinase PyK1 0.0022 0.0294 0.3211
Mycobacterium ulcerans aldehyde dehydrogenase 0.0036 0.0521 0.9807
Onchocerca volvulus 0.0028 0.0385 0.0783
Entamoeba histolytica Ran family GTPase 0.0042 0.0616 0.8934
Echinococcus multilocularis tumor protein p63 0.0336 0.5512 0.5502
Loa Loa (eye worm) hypothetical protein 0.0294 0.4812 0.4812
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0042 0.0616 0.6744
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0528 0.0518
Trichomonas vaginalis set domain proteins, putative 0.0284 0.4637 1
Schistosoma mansoni serine-rich repeat protein 0.0078 0.1217 0.1209
Mycobacterium leprae Probable lipase LipE 0.0036 0.0528 1
Loa Loa (eye worm) CUTiclin-Like family member 0.0006 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0006 0.0024 0.0024
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0026 0.0006
Brugia malayi nuclear hormone receptor 0.0007 0.004 0.0083
Loa Loa (eye worm) hypothetical protein 0.0022 0.0294 0.0294
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0528 0.0968
Trichomonas vaginalis pyruvate kinase, putative 0.0022 0.0294 0.0586
Echinococcus multilocularis thyroid hormone receptor alpha 0.0007 0.004 0.0016
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0015 0.0177 0.1824
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0234 0.2493
Schistosoma mansoni dihydropyridine-sensitive l-type calcium channel 0.0073 0.1135 0.1126
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0007 0.004 0.0016
Trypanosoma cruzi pyruvate kinase 2, putative 0.0022 0.0294 0.1333
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0007 0.004 0.0083
Trypanosoma brucei importin beta-1 subunit, putative 0.0057 0.0866 1
Brugia malayi von Willebrand factor type A domain containing protein 0.0006 0.0024 0.005
Toxoplasma gondii exonuclease III APE 0.0019 0.0234 0.2493
Trypanosoma brucei importin beta-1 subunit, putative 0.0057 0.0866 1
Loa Loa (eye worm) hypothetical protein 0.0006 0.0024 0.0024
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0036 0.0525 0.0515
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0234 0.2402
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0606 1 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.068 0.0671
Leishmania major pyruvate kinase 0.0022 0.0294 0.3307
Brugia malayi von Willebrand factor type A domain containing protein 0.0006 0.0024 0.005
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0528 0.0505
Loa Loa (eye worm) pyruvate kinase 0.0022 0.0294 0.0294
Loa Loa (eye worm) hypothetical protein 0.0036 0.0525 0.0525
Entamoeba histolytica hypothetical protein 0.0015 0.0177 0.2316
Brugia malayi von Willebrand factor type A domain containing protein 0.0006 0.0024 0.005
Loa Loa (eye worm) hypothetical protein 0.0036 0.0528 0.0528
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0026 0.0006
Loa Loa (eye worm) hypothetical protein 0.0036 0.0528 0.0528
Schistosoma mansoni importin-beta 2 0.0011 0.01 0.009
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0234 0.1747
Echinococcus multilocularis pyruvate kinase 0.0022 0.0294 0.0271
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0007 0.004 0.0016
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0528 0.1092
Onchocerca volvulus Protein ultraspiracle homolog 0.0007 0.004 0.0034
Loa Loa (eye worm) kap beta 3 protein 0.0011 0.01 0.01
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0528 0.1092
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0528 0.0968
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0231 0.3763 0.3763
Brugia malayi kap beta 3 protein 0.0011 0.01 0.0208
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0008 0.0058 0.0035
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0015 0.0177 0.1824
Brugia malayi Pyruvate kinase, M2 isozyme 0.0022 0.0294 0.0611
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0007 0.004 0.0083
Onchocerca volvulus Pyruvate kinase homolog 0.0022 0.0294 0.0586
Loa Loa (eye worm) hypothetical protein 0.0007 0.004 0.004
Mycobacterium ulcerans aldehyde dehydrogenase 0.0036 0.0521 0.9807
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0528 0.1096
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0234 0.021
Loa Loa (eye worm) hypothetical protein 0.0007 0.004 0.004
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0007 0.004 0.003
Schistosoma mansoni hypothetical protein 0.0169 0.2732 0.2725
Toxoplasma gondii aldehyde dehydrogenase 0.0036 0.0521 0.5904
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0007 0.004 0.003
Echinococcus granulosus tumor protein p63 0.0336 0.5512 0.5502
Loa Loa (eye worm) hypothetical protein 0.0067 0.1032 0.1032
Loa Loa (eye worm) hypothetical protein 0.0007 0.004 0.004
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0234 0.0486
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0042 0.0616 0.0616
Plasmodium falciparum transportin 0.0011 0.01 0.0904
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0087 0.0063

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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