Detailed information for compound 725987

Basic information

Technical information
  • TDR Targets ID: 725987
  • Name: 1-acetyl-N-(2-bromophenyl)piperidine-4-carbox amide
  • MW: 325.201 | Formula: C14H17BrN2O2
  • H donors: 1 H acceptors: 2 LogP: 1.74 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(C1CCN(CC1)C(=O)C)Nc1ccccc1Br
  • InChi: 1S/C14H17BrN2O2/c1-10(18)17-8-6-11(7-9-17)14(19)16-13-5-3-2-4-12(13)15/h2-5,11H,6-9H2,1H3,(H,16,19)
  • InChiKey: VTKWVDXIUCWREB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-acetyl-N-(2-bromophenyl)-4-piperidinecarboxamide
  • 1-acetyl-N-(2-bromophenyl)isonipecotamide
  • N-(2-bromophenyl)-1-ethanoyl-piperidine-4-carboxamide
  • ZINC06725683
  • IVK/0014984

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.006 0.0201 0.0718
Schistosoma mansoni cellular tumor antigen P53 0.0053 0.0171 0.0157
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0549 0.2615 1
Onchocerca volvulus 0.005 0.0156 0.0973
Echinococcus multilocularis SAM and MBT domain containing protein 0.005 0.0156 0.0141
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0092 0.0742
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0057 0.019 0.0176
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0016 0.0005
Trypanosoma cruzi DNA polymerase eta, putative 0.0022 0.0016 0.0005
Echinococcus multilocularis geminin 0.0195 0.0871 0.0858
Giardia lamblia DINP protein human, muc B family 0.0022 0.0016 1
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.006 0.0201 0.0718
Brugia malayi hypothetical protein 0.0029 0.0051 0.0194
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0095 0.0309
Echinococcus granulosus tissue type plasminogen activator 0.003 0.0056 0.0042
Mycobacterium ulcerans DNA polymerase IV 0.0022 0.0016 0.0005
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.005 0.0156 0.0973
Toxoplasma gondii IMP dehydrogenas 0.0549 0.2615 1
Loa Loa (eye worm) transcription factor SMAD2 0.0242 0.1103 0.4186
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.0361 0.0347
Mycobacterium tuberculosis Probable esterase LipL 0.0038 0.0092 0.03
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0092 0.0742
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0048 0.0034
Echinococcus granulosus neutral alpha glucosidase AB 0.0037 0.0089 0.0075
Loa Loa (eye worm) hypothetical protein 0.0038 0.0092 0.03
Loa Loa (eye worm) hypothetical protein 0.005 0.0156 0.0543
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0203 0.0907 0.0894
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0051 0.014
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0089 0.0711
Loa Loa (eye worm) GMP reductase 0.0243 0.1104 0.4189
Onchocerca volvulus 0.0038 0.0092 0.0372
Echinococcus multilocularis lysosomal alpha glucosidase 0.0166 0.0726 0.0713
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0038 0.0095 0.0309
Onchocerca volvulus 0.0038 0.0092 0.0372
Trypanosoma brucei unspecified product 0.0022 0.0016 0.0005
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0201 0.0718
Echinococcus multilocularis histone acetyltransferase MYST2 0.0057 0.019 0.0176
Leishmania major alpha glucosidase II subunit, putative 0.0037 0.0089 0.0287
Mycobacterium ulcerans lipase LipD 0.0038 0.0092 0.03
Loa Loa (eye worm) MH2 domain-containing protein 0.0242 0.1103 0.4186
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0206 0.0925 0.3501
Mycobacterium ulcerans hypothetical protein 0.0038 0.0092 0.03
Brugia malayi beta-lactamase family protein 0.0038 0.0092 0.0353
Leishmania major DNA polymerase eta, putative 0.0022 0.0016 0.0005
Plasmodium vivax cysteine repeat modular protein 1, putative 0.003 0.0056 0.0162
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0201 0.0187
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena 0.0306 0.1419 0.529
Trypanosoma cruzi hypothetical protein, conserved 0.003 0.0056 0.0162
Brugia malayi mbt repeat family protein 0.005 0.0156 0.0595
Echinococcus multilocularis inosine 5' monophosphate dehydrogenase 2 0.0549 0.2615 0.2604
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0022 0.0016 0.0001
Echinococcus multilocularis tumor protein p63 0.0365 0.1706 0.1694
Mycobacterium leprae Probable lipase LipE 0.0038 0.0092 0.0068
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0038 0.0092 0.03
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.0089 0.929
Loa Loa (eye worm) hypothetical protein 0.0038 0.0092 0.03
Plasmodium falciparum inosine-5'-monophosphate dehydrogenase 0.0549 0.2615 1
Trypanosoma cruzi GMP reductase 0.0549 0.2615 1
Brugia malayi follicle stimulating hormone receptor 0.0244 0.1112 0.4254
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0092 0.0361 0.138
Loa Loa (eye worm) hypothetical protein 0.0172 0.0757 0.2855
Mycobacterium tuberculosis Probable hydrolase 0.0038 0.0092 0.03
Loa Loa (eye worm) hypothetical protein 0.003 0.0056 0.0162
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0092 0.0361 0.0347
Loa Loa (eye worm) mbt repeat family protein 0.005 0.0156 0.0543
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0549 0.2615 1
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0016 0.0005
Brugia malayi inosine-5'-monophosphate dehydrogenase 0.0243 0.1104 0.4221
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0038 0.0095 1
Echinococcus granulosus muscleblind protein 0.0172 0.0757 0.0743
Echinococcus multilocularis neutral alpha glucosidase AB 0.0037 0.0089 0.0075
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0092 0.0742
Brugia malayi Glycosyl hydrolases family 31 protein 0.0166 0.0726 0.2777
Trypanosoma brucei PAB1-binding protein , putative 0.0029 0.0051 0.014
Loa Loa (eye worm) hypothetical protein 0.003 0.0053 0.015
Brugia malayi Glycosyl hydrolases family 31 protein 0.0037 0.0089 0.0341
Trypanosoma brucei hypothetical protein, conserved 0.0038 0.0092 0.03
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0034 0.0075 0.0234
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0089 0.0711
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0022 0.0016 0.0001
Brugia malayi Kringle domain containing protein 0.003 0.0056 0.0216
Echinococcus multilocularis dna polymerase eta 0.0022 0.0016 0.0001
Echinococcus multilocularis dna polymerase kappa 0.0022 0.0016 0.0001
Trypanosoma brucei GMP reductase 0.0549 0.2615 1
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0038 0.0092 0.03
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0016 0.0005
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0038 0.0092 0.03
Loa Loa (eye worm) hypothetical protein 0.0038 0.0092 0.03
Leishmania major hypothetical protein, conserved 0.0029 0.0051 0.014
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0089 0.0711
Brugia malayi MH2 domain containing protein 0.0242 0.1103 0.4218
Plasmodium falciparum cysteine repeat modular protein 1 0.003 0.0056 0.0162
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0022 0.0016 0.0005
Brugia malayi exodeoxyribonuclease III family protein 0.0022 0.0014 0.0055
Loa Loa (eye worm) IMP dehydrogenase 1 0.0549 0.2615 1
Trypanosoma cruzi GMP reductase 0.0549 0.2615 1
Trypanosoma brucei glucosidase, putative 0.0037 0.0089 0.0287
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0016 0.0005
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB3 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.0306 0.1419 0.54
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0022 0.0016 0.0001
Echinococcus multilocularis microtubule associated protein 2 0.2046 1 1
Brugia malayi beta-lactamase 0.0038 0.0092 0.0353
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0089 0.0711
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.0095 0.0766
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0016 0.0005
Toxoplasma gondii ABC1 family protein 0.0038 0.0092 0.03
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0053 0.015
Loa Loa (eye worm) hypothetical protein 0.0038 0.0092 0.03
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0095 0.0309
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0038 0.0095 0.0309
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0092 0.0078
Echinococcus multilocularis lysosomal alpha glucosidase 0.0166 0.0726 0.0713
Trichomonas vaginalis sucrase-isomaltase, putative 0.0037 0.0089 0.0711
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0038 0.0092 0.03
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.0549 0.2615 1
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) 0.0549 0.2615 1
Echinococcus granulosus polycomb protein SCMH1 0.005 0.0156 0.0141
Trichomonas vaginalis set domain proteins, putative 0.0235 0.1065 1
Mycobacterium ulcerans beta-lactamase 0.0038 0.0092 0.03
Mycobacterium tuberculosis Possible penicillin-binding protein 0.024 0.1089 0.4133
Mycobacterium tuberculosis Conserved protein 0.0038 0.0092 0.03
Brugia malayi Inositol-1 0.0038 0.0095 0.0363
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0089 0.0711
Brugia malayi beta-lactamase family protein 0.0038 0.0092 0.0353
Schistosoma mansoni inositol monophosphatase 0.0038 0.0095 0.0081
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0092 0.03
Schistosoma mansoni alpha glucosidase 0.0037 0.0089 0.0075
Brugia malayi Muscleblind-like protein 0.0172 0.0757 0.2894
Echinococcus multilocularis muscleblind protein 0.0172 0.0757 0.0743
Loa Loa (eye worm) hypothetical protein 0.0022 0.0016 0.0005
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0166 0.0726 0.2737
Trichomonas vaginalis esterase, putative 0.0038 0.0092 0.0742
Brugia malayi ImpB/MucB/SamB family protein 0.0022 0.0016 0.006
Toxoplasma gondii LsmAD domain-containing protein 0.0029 0.0051 0.014
Loa Loa (eye worm) MBCTL1 0.0057 0.019 0.0675
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.0361 0.0347
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.0095 0.0766
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0051 0.014
Mycobacterium tuberculosis Probable lipase LipD 0.0038 0.0092 0.03
Brugia malayi inosine-5'-monophosphate dehydrogenase 0.0243 0.1104 0.4221
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0053 0.0039
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0244 0.1112 0.4222
Echinococcus granulosus inosine 5' monophosphate dehydrogenase 2 0.0549 0.2615 0.2604
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0022 0.0016 0.0005
Loa Loa (eye worm) inositol-1 0.0038 0.0095 0.0309
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0089 0.0287
Schistosoma mansoni inositol monophosphatase 0.0038 0.0095 0.0081
Mycobacterium leprae PROBABLE INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE GUAB1(IMP DEHYDROGENASE) (IMPDH) (IMPD) 0.0243 0.1104 0.4049
Loa Loa (eye worm) beta-lactamase 0.0038 0.0092 0.03
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0095 0.0309
Echinococcus granulosus SAM and MBT domain containing protein 0.005 0.0156 0.0141
Echinococcus multilocularis tissue type plasminogen activator 0.003 0.0056 0.0042
Echinococcus multilocularis muscleblind protein 1 0.0172 0.0757 0.0743
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0057 0.019 0.0726
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0016 0.0005
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0016 0.0005
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0038 0.0092 0.03
Entamoeba histolytica deoxycytidyl transferase, putative 0.0022 0.0016 0.0171
Echinococcus granulosus tumor protein p63 0.0365 0.1706 0.1694
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0201 0.0718
Schistosoma mansoni hypothetical protein 0.003 0.0056 0.0042
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0095 0.0309
Mycobacterium tuberculosis Conserved hypothetical protein 0.0022 0.0016 0.0005
Mycobacterium tuberculosis Conserved protein 0.0038 0.0092 0.03
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0053 0.0039
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0092 0.03
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.006 0.0201 0.0187
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0016 0.0005
Onchocerca volvulus 0.0096 0.0381 0.312
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0053 0.0039
Schistosoma mansoni hypothetical protein 0.0195 0.0871 0.0858
Echinococcus granulosus inositol monophosphatase 1 0.0038 0.0095 0.0081
Echinococcus granulosus geminin 0.0195 0.0871 0.0858
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0016 0.0005
Mycobacterium tuberculosis Probable lipase LipE 0.0038 0.0092 0.03
Mycobacterium leprae conserved hypothetical protein 0.0038 0.0092 0.0068
Echinococcus granulosus beta LACTamase domain containing family member 0.0038 0.0092 0.0078
Brugia malayi GMP reductase 0.0243 0.1104 0.4221
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0022 0.0016 0.0005
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0051 0.014
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.0243 0.1104 0.4189
Schistosoma mansoni microtubule-associated protein tau 0.2046 1 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0092 0.0361 0.1332
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0092 0.0361 0.0347
Leishmania major hypothetical protein, conserved 0.0038 0.0092 0.03
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0051 0.014
Trichomonas vaginalis DNA polymerase eta, putative 0.0022 0.0016 0.0013
Plasmodium vivax SET domain protein, putative 0.003 0.0053 0.015
Brugia malayi Pre-SET motif family protein 0.003 0.0053 0.0204
Toxoplasma gondii kringle domain-containing protein 0.003 0.0056 0.0162
Trichomonas vaginalis inositol monophosphatase, putative 0.0038 0.0095 0.0766
Schistosoma mansoni inosine-5-monophosphate dehydrogenase 0.0549 0.2615 0.2604
Echinococcus granulosus dna polymerase eta 0.0022 0.0016 0.0001
Brugia malayi Pre-SET motif family protein 0.0206 0.0925 0.3537
Leishmania major hypothetical protein, conserved 0.003 0.0056 0.0162
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0053 0.0039
Mycobacterium ulcerans inosine 5'-monophosphate dehydrogenase 0.0549 0.2615 1
Trichomonas vaginalis maltase-glucoamylase, putative 0.0037 0.0089 0.0711
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0016 0.0005
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0016 0.0005
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0092 0.0078
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0038 0.0092 0.0353
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.0089 0.929
Leishmania major guanosine monophosphate reductase 0.0549 0.2615 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0016 0.0005
Echinococcus multilocularis inositol monophosphatase 1 0.0038 0.0095 0.0081
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0201 0.0187
Trypanosoma brucei DNA polymerase eta, putative 0.0022 0.0016 0.0005
Loa Loa (eye worm) hypothetical protein 0.0057 0.019 0.0675
Onchocerca volvulus 0.0235 0.1065 0.9637
Loa Loa (eye worm) hypothetical protein 0.0029 0.0051 0.014
Schistosoma mansoni sex comb on midleg homolog 0.005 0.0156 0.0141
Echinococcus granulosus histone acetyltransferase MYST2 0.0057 0.019 0.0176
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0089 0.0711
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0053 0.0039
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0092 0.0361 0.0347
Mycobacterium tuberculosis Conserved protein 0.0038 0.0092 0.03
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0022 0.0016 0.0013
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0089 0.0711
Echinococcus multilocularis beta LACTamase domain containing family member 0.0038 0.0092 0.0078
Schistosoma mansoni alpha-glucosidase 0.0143 0.0612 0.0599
Echinococcus granulosus dna polymerase kappa 0.0022 0.0016 0.0001
Onchocerca volvulus Putative GMP reductase 0.0243 0.1104 1
Brugia malayi Protein kinase domain containing protein 0.003 0.0056 0.0216
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0089 0.0287
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0201 0.0718
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.0549 0.2615 1
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0092 0.0742
Mycobacterium ulcerans DNA polymerase IV 0.0022 0.0016 0.0005
Leishmania major DNA polymerase kappa, putative 0.0022 0.0016 0.0005
Schistosoma mansoni hypothetical protein 0.031 0.1437 0.1425
Schistosoma mansoni myelin transcription factor 1 myt1 0.0057 0.019 0.0176
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0053 0.0039
Schistosoma mansoni sex comb on midleg homolog 0.005 0.0156 0.0141
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0016 0.0005
Plasmodium vivax inosine-5'-monophosphate dehydrogenase, putative 0.0549 0.2615 1
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0203 0.0907 0.0894
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0053 0.0039
Loa Loa (eye worm) hypothetical protein 0.0053 0.0171 0.0601
Onchocerca volvulus 0.0038 0.0092 0.0372
Schistosoma mansoni hypothetical protein 0.0195 0.0871 0.0858
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.005 0.0156 0.0141
Wolbachia endosymbiont of Brugia malayi IMP dehydrogenase 0.0549 0.2615 1
Mycobacterium ulcerans esterase/lipase LipP 0.0038 0.0092 0.03
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0037 0.0089 0.0287
Brugia malayi ImpB/MucB/SamB family protein 0.0022 0.0016 0.006
Loa Loa (eye worm) hypothetical protein 0.0038 0.0092 0.03
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0092 0.0742
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0016 0.0005
Echinococcus granulosus lysosomal alpha glucosidase 0.0166 0.0726 0.0713
Loa Loa (eye worm) TK/ROR protein kinase 0.003 0.0056 0.0162
Onchocerca volvulus 0.0053 0.0171 0.1117
Onchocerca volvulus 0.003 0.0056 0.0029
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0016 0.0005
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0549 0.2615 1
Trypanosoma brucei inosine-5'-monophosphate dehydrogenase 0.0549 0.2615 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0016 0.0005
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.0361 0.0347
Schistosoma mansoni terminal deoxycytidyl transferase 0.0022 0.0016 0.0001
Toxoplasma gondii aldehyde dehydrogenase 0.006 0.0201 0.0718
Schistosoma mansoni DNA polymerase eta 0.0022 0.0016 0.0001
Brugia malayi inosine-5'-monophosphate dehydrogenase family protein 0.0549 0.2615 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0092 0.0361 0.0347
Plasmodium vivax ataxin-2 like protein, putative 0.0029 0.0051 0.014
Schistosoma mansoni alpha-glucosidase 0.0143 0.0612 0.0599
Leishmania major inosine-5-monophosphate dehydrogenase 0.0549 0.2615 1
Treponema pallidum exodeoxyribonuclease (exoA) 0.0022 0.0014 0.5
Plasmodium vivax hypothetical protein, conserved 0.0038 0.0092 0.03
Echinococcus multilocularis polycomb protein SCMH1 0.005 0.0156 0.0141
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0057 0.019 0.0176
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.006 0.0201 0.0187
Loa Loa (eye worm) hypothetical protein 0.0172 0.0757 0.2855
Loa Loa (eye worm) hypothetical protein 0.0038 0.0092 0.03
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0038 0.0095 0.0309
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0016 0.0005
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0037 0.0089 0.0287
Brugia malayi mbt repeat family protein 0.005 0.0156 0.0595

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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