Detailed information for compound 726112

Basic information

Technical information
  • TDR Targets ID: 726112
  • Name: 1-(phenylmethyl)-4-(1-propylbenzimidazol-2-yl )pyrrolidin-2-one
  • MW: 333.427 | Formula: C21H23N3O
  • H donors: 0 H acceptors: 2 LogP: 3.05 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCn1c(nc2c1cccc2)C1CC(=O)N(C1)Cc1ccccc1
  • InChi: 1S/C21H23N3O/c1-2-12-24-19-11-7-6-10-18(19)22-21(24)17-13-20(25)23(15-17)14-16-8-4-3-5-9-16/h3-11,17H,2,12-15H2,1H3
  • InChiKey: MDYSZPHLVHPHLT-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-(phenylmethyl)-4-(1-propyl-2-benzimidazolyl)-2-pyrrolidinone
  • 1-(benzyl)-4-(1-propylbenzimidazol-2-yl)-2-pyrrolidone
  • IFLab1_002892
  • IDI1_009351
  • ST5145645

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus Matrilysin homolog 0.0047 0.0182 0.0641
Brugia malayi GMP reductase 0.03 0.2041 0.4232
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0206 0.0428
Mycobacterium tuberculosis Conserved protein 0.0036 0.0107 0.0165
Onchocerca volvulus 0.0036 0.0107 0.0261
Echinococcus multilocularis SAM and MBT domain containing protein 0.005 0.0207 0.0207
Brugia malayi Glycosyl hydrolases family 31 protein 0.0036 0.0105 0.0218
Toxoplasma gondii IMP dehydrogenas 0.0678 0.4823 1
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.011 0.0697
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0024 0.005
Plasmodium vivax importin-beta 2, putative 0.003 0.0058 0.012
Trichomonas vaginalis esterase, putative 0.0036 0.0107 0.0674
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0107 0.0165
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.011 0.0697
Echinococcus multilocularis inosine 5' monophosphate dehydrogenase 2 0.0678 0.4823 0.4823
Leishmania major hypothetical protein, conserved 0.0036 0.0107 0.0221
Mycobacterium ulcerans hypothetical protein 0.0036 0.0107 0.0165
Loa Loa (eye worm) GMP reductase 0.03 0.2041 0.4232
Brugia malayi mbt repeat family protein 0.005 0.0207 0.043
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0107 0.0107
Mycobacterium tuberculosis Conserved protein 0.0036 0.0107 0.0165
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) 0.0678 0.4823 1
Echinococcus granulosus lysosomal alpha glucosidase 0.0163 0.1039 0.1039
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0026 0.0027 0.0057
Echinococcus granulosus snurportin 1 0.0317 0.2172 0.2172
Loa Loa (eye worm) hypothetical protein 0.005 0.0206 0.0428
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0057 0.0258 0.0258
Trypanosoma cruzi GMP reductase 0.0678 0.4823 1
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena 0.0378 0.2621 0.5409
Loa Loa (eye worm) MBCTL1 0.0057 0.0258 0.0536
Loa Loa (eye worm) TK/ROR protein kinase 0.0029 0.0055 0.0113
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0107 0.0107
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0105 0.0666
Toxoplasma gondii ABC1 family protein 0.0036 0.0107 0.0221
Schistosoma mansoni ADAM17 peptidase (M12 family) 0.0178 0.1148 0.1148
Echinococcus granulosus polycomb protein SCMH1 0.005 0.0207 0.0207
Mycobacterium leprae Probable lipase LipE 0.0036 0.0107 0.0165
Schistosoma mansoni inositol monophosphatase 0.0037 0.011 0.011
Schistosoma mansoni adam (A disintegrin and metalloprotease 0.0031 0.0067 0.0067
Echinococcus granulosus tissue type plasminogen activator 0.0029 0.0055 0.0055
Brugia malayi RNA, U transporter 1 0.0085 0.0461 0.0955
Loa Loa (eye worm) hypothetical protein 0.005 0.0207 0.043
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0024 0.005
Brugia malayi beta-lactamase family protein 0.0036 0.0107 0.0221
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0036 0.0105 0.0218
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0206 0.0428
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0208 0.137 0.2841
Schistosoma mansoni sex comb on midleg homolog 0.005 0.0207 0.0207
Echinococcus multilocularis tumor protein p63 0.0358 0.2473 0.2473
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0105 0.0218
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0107 0.0674
Echinococcus multilocularis adam 17 protease 0.0178 0.1148 0.1148
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0029 0.0055 0.0113
Schistosoma mansoni alpha glucosidase 0.0036 0.0105 0.0105
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.009 0.0504 0.0504
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0107 0.0221
Brugia malayi Importin beta-1 subunit 0.003 0.0058 0.012
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0076 0.0401 0.0401
Echinococcus granulosus adam 0.0031 0.0067 0.0067
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0105 0.0666
Trichomonas vaginalis set domain proteins, putative 0.0237 0.1582 1
Mycobacterium tuberculosis Conserved protein 0.0036 0.0107 0.0165
Onchocerca volvulus 0.003 0.0058 0.0019
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0057 0.0258 0.0258
Echinococcus granulosus histone acetyltransferase MYST2 0.0057 0.0258 0.0258
Loa Loa (eye worm) hypothetical protein 0.0025 0.0024 0.005
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0107 0.0165
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0107 0.0165
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.0504 0.0504
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0036 0.0105 0.0218
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.011 0.0228
Plasmodium falciparum cysteine repeat modular protein 1 0.0029 0.0055 0.0113
Loa Loa (eye worm) hypothetical protein 0.0036 0.0107 0.0221
Schistosoma mansoni microtubule-associated protein tau 0.1382 1 1
Echinococcus multilocularis importin subunit beta 1 0.003 0.0058 0.0058
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0024 0.005
Wolbachia endosymbiont of Brugia malayi IMP dehydrogenase 0.0678 0.4823 1
Schistosoma mansoni hypothetical protein 0.003 0.0058 0.0058
Onchocerca volvulus 0.0237 0.1582 0.7686
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.009 0.0504 0.1044
Trypanosoma brucei GMP reductase 0.0678 0.4823 1
Onchocerca volvulus 0.0094 0.0533 0.2408
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.009 0.0187
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0037 0.011 1
Echinococcus multilocularis inositol monophosphatase 1 0.0037 0.011 0.011
Loa Loa (eye worm) hypothetical protein 0.0036 0.0107 0.0221
Trypanosoma brucei glucosidase, putative 0.0036 0.0105 0.0218
Schistosoma mansoni sex comb on midleg homolog 0.005 0.0207 0.0207
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.0504 0.0504
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0059 0.0059
Echinococcus granulosus a disintegrin and metalloproteinase with 0.0084 0.0457 0.0457
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0059 0.0059
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.005 0.0207 0.0769
Loa Loa (eye worm) hypothetical protein 0.0036 0.0107 0.0221
Schistosoma mansoni importin beta-1 0.003 0.0058 0.0058
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0107 0.0674
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.011 0.0228
Brugia malayi follicle stimulating hormone receptor 0.0243 0.1627 0.3374
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.009 0.0504 0.0504
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0107 0.0165
Onchocerca volvulus 0.005 0.0207 0.0769
Loa Loa (eye worm) hypothetical protein 0.003 0.0059 0.0122
Brugia malayi mbt repeat family protein 0.005 0.0207 0.043
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.0276 0.0276
Brugia malayi Glycosyl hydrolases family 31 protein 0.0163 0.1039 0.2153
Onchocerca volvulus 0.0036 0.0107 0.0261
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0276 0.0276
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0276 0.0517
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0051 0.0051
Brugia malayi beta-lactamase family protein 0.0036 0.0107 0.0221
Schistosoma mansoni cellular tumor antigen P53 0.0052 0.0225 0.0225
Schistosoma mansoni alpha-glucosidase 0.014 0.0872 0.0872
Echinococcus granulosus SAM and MBT domain containing protein 0.005 0.0207 0.0207
Brugia malayi Hemopexin family protein 0.003 0.0058 0.0121
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0016 0.0034
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0022 0 0.5
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0107 0.0165
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0107 0.0165
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0206 0.0428
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0105 0.0666
Loa Loa (eye worm) hypothetical protein 0.0034 0.009 0.0187
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0105 0.0666
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0107 0.0221
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0033 0.0082 0.0113
Brugia malayi Pre-SET motif family protein 0.0208 0.137 0.2841
Loa Loa (eye worm) hypothetical protein 0.0036 0.0107 0.0221
Echinococcus multilocularis neutral alpha glucosidase AB 0.0036 0.0105 0.0105
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB3 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.0378 0.2621 0.5409
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0105 0.0218
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0016 0.0103
Schistosoma mansoni myelin transcription factor 1 myt1 0.0057 0.0258 0.0258
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0037 0.011 0.0228
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0107 0.0165
Trypanosoma cruzi GMP reductase 0.0678 0.4823 1
Echinococcus granulosus importin subunit beta 1 0.003 0.0058 0.0058
Leishmania major inosine-5-monophosphate dehydrogenase 0.0678 0.4823 1
Leishmania major importin beta-1 subunit, putative 0.0024 0.0016 0.0034
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.0678 0.4823 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0232 0.1547 0.3169
Loa Loa (eye worm) inositol-1 0.0037 0.011 0.0228
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0105 0.0666
Onchocerca volvulus 0.0036 0.0107 0.0261
Schistosoma mansoni hypothetical protein 0.0034 0.009 0.009
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0197 0.129 0.129
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0276 0.0276
Loa Loa (eye worm) hypothetical protein 0.0374 0.259 0.5369
Echinococcus multilocularis a disintegrin and metalloproteinase with 0.0084 0.0457 0.0457
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0105 0.0666
Brugia malayi Matrixin family protein 0.0051 0.0213 0.0441
Loa Loa (eye worm) mbt repeat family protein 0.005 0.0207 0.043
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0058 0.012
Echinococcus multilocularis histone acetyltransferase MYST2 0.0057 0.0258 0.0258
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.0276 0.0517
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0076 0.0401 0.0401
Echinococcus multilocularis tissue type plasminogen activator 0.0029 0.0055 0.0055
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0276 0.0517
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0057 0.0258 0.0536
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0107 0.0674
Trichomonas vaginalis inositol monophosphatase, putative 0.0037 0.011 0.0697
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.009 0.0504 0.1044
Mycobacterium ulcerans lipase LipD 0.0036 0.0107 0.0165
Loa Loa (eye worm) beta-lactamase 0.0036 0.0107 0.0221
Trichomonas vaginalis sucrase-isomaltase, putative 0.0036 0.0105 0.0666
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0024 0.005
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.0058 0.012
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0107 0.0221
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.0504 0.0504
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.011 0.0228
Toxoplasma gondii kringle domain-containing protein 0.0029 0.0055 0.0113
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0107 0.0221
Schistosoma mansoni inositol monophosphatase 0.0037 0.011 0.011
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0276 0.0517
Brugia malayi inosine-5'-monophosphate dehydrogenase 0.03 0.2041 0.4232
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0678 0.4823 1
Echinococcus granulosus inositol monophosphatase 1 0.0037 0.011 0.011
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0107 0.0107
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0107 0.0674
Echinococcus multilocularis snurportin 1 0.0317 0.2172 0.2172
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0059 0.0059
Brugia malayi hypothetical protein 0.0025 0.0024 0.005
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0037 0.011 0.0173
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.005 0.0207 0.0207
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.009 0.0504 0.0504
Echinococcus granulosus adam 17 protease 0.0196 0.1279 0.1279
Loa Loa (eye worm) hypothetical protein 0.003 0.0058 0.012
Brugia malayi inosine-5'-monophosphate dehydrogenase family protein 0.0678 0.4823 1
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0105 0.9564
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0105 0.9564
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0678 0.4823 1
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0059 0.0059
Echinococcus granulosus neutral alpha glucosidase AB 0.0036 0.0105 0.0105
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0197 0.129 0.129
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0059 0.0059
Loa Loa (eye worm) matrixin family protein 0.0051 0.0213 0.0441
Brugia malayi metalloprotease disintegrin 16 with thrombospondin type I motif 0.0084 0.0457 0.0948
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.0276 0.0571
Trichomonas vaginalis maltase-glucoamylase, putative 0.0036 0.0105 0.0666
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0024 0.005
Onchocerca volvulus Putative GMP reductase 0.03 0.2041 1
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0163 0.1039 0.2153
Mycobacterium leprae PROBABLE INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE GUAB1(IMP DEHYDROGENASE) (IMPDH) (IMPD) 0.03 0.2041 0.4199
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.009 0.0504 0.0504
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0107 0.0165
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0243 0.1627 0.3374
Plasmodium falciparum inosine-5'-monophosphate dehydrogenase 0.0678 0.4823 1
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0033 0.0082 0.0113
Echinococcus granulosus Blood coagulation inhibitor Disintegrin 0.0112 0.0661 0.0661
Loa Loa (eye worm) hypothetical protein 0.0036 0.0107 0.0221
Entamoeba histolytica hypothetical protein 0.0024 0.0016 0.1485
Brugia malayi MH2 domain containing protein 0.0238 0.1591 0.3298
Trypanosoma brucei inosine-5'-monophosphate dehydrogenase 0.0678 0.4823 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0105 0.0666
Echinococcus multilocularis adam 0.0031 0.0067 0.0067
Onchocerca volvulus Matrix metalloproteinase homolog 0.0047 0.0182 0.0641
Echinococcus multilocularis lysosomal alpha glucosidase 0.0163 0.1039 0.1039
Echinococcus multilocularis Blood coagulation inhibitor, Disintegrin 0.0112 0.0661 0.0661
Echinococcus multilocularis lysosomal alpha glucosidase 0.0163 0.1039 0.1039
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0059 0.0059
Leishmania major guanosine monophosphate reductase 0.0678 0.4823 1
Plasmodium vivax SET domain protein, putative 0.003 0.0059 0.0122
Brugia malayi Inositol-1 0.0037 0.011 0.0228
Onchocerca volvulus 0.0052 0.0225 0.0856
Schistosoma mansoni hypothetical protein 0.0304 0.2078 0.2078
Loa Loa (eye worm) hypothetical protein 0.0026 0.0027 0.0057
Plasmodium falciparum importin beta, putative 0.003 0.0058 0.012
Schistosoma mansoni hypothetical protein 0.0029 0.0055 0.0055
Loa Loa (eye worm) hypothetical protein 0.0057 0.0258 0.0536
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0107 0.0221
Brugia malayi Pre-SET motif family protein 0.003 0.0059 0.0122
Brugia malayi beta-lactamase 0.0036 0.0107 0.0221
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0317 0.2172 0.4502
Loa Loa (eye worm) hypothetical protein 0.0036 0.0107 0.0221
Schistosoma mansoni hypothetical protein 0.0317 0.2172 0.2172
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.0678 0.4823 1
Echinococcus granulosus inosine 5' monophosphate dehydrogenase 2 0.0678 0.4823 0.4823
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.03 0.2041 0.4199
Loa Loa (eye worm) MH2 domain-containing protein 0.0238 0.1591 0.3298
Loa Loa (eye worm) transcription factor SMAD2 0.0238 0.1591 0.3298
Loa Loa (eye worm) IMP dehydrogenase 1 0.0678 0.4823 1
Brugia malayi inosine-5'-monophosphate dehydrogenase 0.03 0.2041 0.4232
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.0276 0.0571
Onchocerca volvulus 0.003 0.0059 0.0021
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.011 0.0228
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0059 0.0059
Mycobacterium ulcerans inosine 5'-monophosphate dehydrogenase 0.0678 0.4823 1
Loa Loa (eye worm) hypothetical protein 0.0052 0.0225 0.0466
Trypanosoma cruzi hypothetical protein, conserved 0.0029 0.0055 0.0113
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0107 0.0165
Schistosoma mansoni inosine-5-monophosphate dehydrogenase 0.0678 0.4823 0.4823
Loa Loa (eye worm) hypothetical protein 0.0029 0.0055 0.0113
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0678 0.4823 1
Echinococcus multilocularis microtubule associated protein 2 0.1382 1 1
Plasmodium vivax inosine-5'-monophosphate dehydrogenase, putative 0.0678 0.4823 1
Leishmania major hypothetical protein, conserved 0.0025 0.0024 0.005
Schistosoma mansoni alpha-glucosidase 0.014 0.0872 0.0872
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0107 0.0221
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0016 0.0103
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0024 0.005
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0016 0.0103
Leishmania major alpha glucosidase II subunit, putative 0.0036 0.0105 0.0218
Echinococcus multilocularis polycomb protein SCMH1 0.005 0.0207 0.0207
Loa Loa (eye worm) matrixin family protein 0.0047 0.0182 0.0377
Brugia malayi hypothetical protein 0.0031 0.0067 0.0138
Leishmania major hypothetical protein, conserved 0.0029 0.0055 0.0113
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0107 0.0165
Brugia malayi Kringle domain containing protein 0.0029 0.0055 0.0113
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0107 0.0674
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0058 0.012
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0024 0.005
Echinococcus granulosus tumor protein p63 0.0358 0.2473 0.2473
Mycobacterium ulcerans beta-lactamase 0.0036 0.0107 0.0165
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0059 0.0122
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.0276 0.0276
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0107 0.0107
Brugia malayi Protein kinase domain containing protein 0.0029 0.0055 0.0113
Schistosoma mansoni ADAMTS5 peptidase (M12 family) 0.0084 0.0457 0.0457

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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