TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 263.332 | Formula: C15H21NO3
H donors: 0 H acceptors: 1 LogP: 2.04 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: COc1cc(ccc1OC)C(=O)C1CCCN(C1)C
InChi: 1S/C15H21NO3/c1-16-8-4-5-12(10-16)15(17)11-6-7-13(18-2)14(9-11)19-3/h6-7,9,12H,4-5,8,10H2,1-3H3
InChiKey: KZSVNWDVAWVMLL-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0048	0.0207	0.0207
Trichomonas vaginalis	glucose transporter, putative	0.0099	0.0568	0.2108
Onchocerca volvulus		0.0045	0.0188	0.1143
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0096	0.0545	0.0545
Trichomonas vaginalis	conserved hypothetical protein	0.0045	0.0188	0.0169
Mycobacterium ulcerans	acyl-CoA synthetase	0.0047	0.0204	0.3556
Onchocerca volvulus		0.0045	0.0188	0.1143
Trypanosoma cruzi	hexose transporter, putative	0.0045	0.0188	0.0661
Mycobacterium ulcerans	acyl-CoA synthetase	0.0047	0.0204	0.3556
Schistosoma mansoni	cellular tumor antigen P53	0.0098	0.0563	0.0563
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0319	0.2113	0.2113
Trichomonas vaginalis	conserved hypothetical protein	0.0045	0.0188	0.0169
Chlamydia trachomatis	lysine--tRNA ligase	0.0071	0.0373	1
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.0061	0.0298	0.1219
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0419	0.1984
Echinococcus multilocularis	tar DNA binding protein	0.0061	0.0304	0.0304
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0151	0.0929	0.4395
Mycobacterium ulcerans	fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT	0.0045	0.0188	0.2954
Schistosoma mansoni	sugar transporter	0.0045	0.0188	0.0188
Trichomonas vaginalis	sugar transporter, putative	0.0045	0.0188	0.0169
Trichomonas vaginalis	sugar transport protein, putative	0.0045	0.0188	0.0169
Plasmodium vivax	hexose transporter	0.0319	0.2113	0.2172
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0188	0.0891
Giardia lamblia	Lysyl-tRNA synthetase	0.0071	0.0373	0.5182
Echinococcus granulosus	solute carrier family 22	0.0045	0.0188	0.0188
Plasmodium vivax	CDK-related protein kinase 6, putative	0.1356	0.9381	1
Mycobacterium ulcerans	hypothetical protein	0.004	0.0155	0.1692
Trichomonas vaginalis	conserved hypothetical protein	0.0045	0.0188	0.0169
Mycobacterium tuberculosis	Conserved protein	0.004	0.0155	0.0307
Brugia malayi	hypothetical protein	0.0262	0.171	0.8093
Trichomonas vaginalis	sugar transporter, putative	0.0045	0.0188	0.0169
Mycobacterium leprae	Probable prolyl tRNA synthetase ProS	0.0096	0.0545	1
Onchocerca volvulus		0.0045	0.0188	0.1143
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0099	0.0568	0.8232
Plasmodium falciparum	lysine--tRNA ligase	0.0071	0.0373	0.0273
Echinococcus granulosus	beta LACTamase domain containing family member	0.004	0.0155	0.0155
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0045	0.0188	0.0891
Onchocerca volvulus		0.0045	0.0188	0.1143
Trypanosoma cruzi	sugar transporter, putative	0.0045	0.0188	0.0661
Trichomonas vaginalis	sugar transporter, putative	0.0045	0.0188	0.0169
Schistosoma mansoni	protein kinase	0.0098	0.0559	0.0559
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0032	0.0097	0.0097
Mycobacterium ulcerans	esterase/lipase LipP	0.004	0.0155	0.1692
Schistosoma mansoni	glucose transport protein	0.0319	0.2113	0.2113
Loa Loa (eye worm)	calcium/calmodulin-dependent protein kinase ID	0.0098	0.0559	0.2646
Mycobacterium ulcerans	acyl-CoA synthetase	0.0047	0.0204	0.3556
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0097	0.0458
Plasmodium vivax	calcium-dependent protein kinase 3, putative	0.0098	0.056	0.0499
Leishmania major	4-coumarate:coa ligase-like protein	0.0047	0.0204	0.0976
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0112	0.0657	1
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0047	0.0204	0.1254
Schistosoma mansoni	tar DNA-binding protein	0.0061	0.0304	0.0304
Brugia malayi	hypothetical protein	0.0045	0.0188	0.0891
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.004	0.0155	0.1692
Leishmania major	4-coumarate:coa ligase-like protein	0.0047	0.0204	0.0976
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0563	0.2665
Trypanosoma brucei	glucose transporter, putative	0.0099	0.0568	0.8232
Schistosoma mansoni	serine/threonine protein kinase	0.0098	0.0559	0.0559
Schistosoma mansoni	hypothetical protein	0.0319	0.2113	0.2113
Trypanosoma brucei	glucose transporter 1E	0.0099	0.0568	0.8232
Brugia malayi	beta-lactamase family protein	0.004	0.0155	0.0734
Echinococcus granulosus	lysyl tRNA synthetase	0.0071	0.0373	0.0373
Trichomonas vaginalis	conserved hypothetical protein	0.0099	0.0568	0.2108
Trypanosoma brucei	glucose transporter, putative	0.0099	0.0568	0.8232
Onchocerca volvulus		0.0045	0.0188	0.1143
Trichomonas vaginalis	sugar transporter, putative	0.0099	0.0568	0.2108
Brugia malayi	RNA binding protein	0.0061	0.0304	0.1438
Schistosoma mansoni	sugar transporter	0.0045	0.0188	0.0188
Mycobacterium tuberculosis	Probable lipase LipD	0.004	0.0155	0.0307
Schistosoma mansoni	glucose transporter	0.0045	0.0188	0.0188
Echinococcus multilocularis	calcium dependent protein kinase	0.0092	0.0517	0.0517
Brugia malayi	Pre-SET motif family protein	0.0222	0.1431	0.6774
Schistosoma mansoni	hypothetical protein	0.004	0.0153	0.0153
Trichomonas vaginalis	sugar transporter, putative	0.0045	0.0188	0.0169
Trypanosoma brucei	glucose transporter, putative	0.0099	0.0568	0.8232
Brugia malayi	beta-lactamase	0.004	0.0155	0.0734
Loa Loa (eye worm)	hypothetical protein	0.0035	0.012	0.057
Plasmodium vivax	hypothetical protein, conserved	0.004	0.0155	0.0063
Onchocerca volvulus		0.004	0.0155	0.0942
Trichomonas vaginalis	sugar transporter, putative	0.0045	0.0188	0.0169
Schistosoma mansoni	lysyl-tRNA synthetase	0.0071	0.0373	0.0373
Loa Loa (eye worm)	hypothetical protein	0.0262	0.171	0.8093
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0188	0.0891
Loa Loa (eye worm)	hypothetical protein	0.0096	0.0545	0.258
Trichomonas vaginalis	set domain proteins, putative	0.0253	0.1647	0.7618
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.004	0.0153	0.0153
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0188	0.0891
Trichomonas vaginalis	sugar transporter, putative	0.0045	0.0188	0.0169
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 2 LysX	0.0061	0.0298	0.1219
Trypanosoma brucei	glucose transporter, putative	0.0099	0.0568	0.8232
Giardia lamblia	Prolyl-tRNA synthetase	0.0096	0.0545	1
Trichomonas vaginalis	sugar transporter, putative	0.0045	0.0188	0.0169
Entamoeba histolytica	hypothetical protein	0.0071	0.0373	0.5425
Treponema pallidum	prolyl-tRNA synthetase	0.0034	0.0111	0.5
Trypanosoma brucei	glucose transporter, putative	0.0099	0.0568	0.8232
Brugia malayi	hypothetical protein	0.0045	0.0188	0.0891
Loa Loa (eye worm)	CAMK/CAMK2 protein kinase	0.0098	0.0559	0.2646
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0032	0.0097	0.0097
Entamoeba histolytica	acyl-coA synthetase, putative	0.0047	0.0204	0.1261
Mycobacterium ulcerans	lipase LipD	0.004	0.0155	0.1692
Brugia malayi	RNA recognition motif domain containing protein	0.0061	0.0304	0.1438
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0222	0.1431	0.6774
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0207	0.098
Leishmania major	hypothetical protein, conserved	0.0045	0.0188	0.0661
Schistosoma mansoni	hypothetical protein	0.0053	0.0248	0.0248
Trichomonas vaginalis	sugar transporter, putative	0.0045	0.0188	0.0169
Onchocerca volvulus		0.0045	0.0188	0.1143
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.004	0.0155	0.0155
Mycobacterium ulcerans	sugar transporter	0.0045	0.0188	0.2954
Toxoplasma gondii	prolyl-tRNA synthetase (ProRS)	0.0112	0.0657	0.0917
Loa Loa (eye worm)	TAR-binding protein	0.0061	0.0304	0.1438
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.004	0.0153	0.0153
Schistosoma mansoni	tar DNA-binding protein	0.0061	0.0304	0.0304
Loa Loa (eye worm)	hypothetical protein	0.004	0.0155	0.0734
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0048	0.0207	0.098
Brugia malayi	TAR-binding protein	0.0061	0.0304	0.1438
Trichomonas vaginalis	glucose transporter, putative	0.0099	0.0568	0.2108
Entamoeba histolytica	protein kinase, putative	0.0098	0.0559	1
Brugia malayi	hypothetical protein	0.0045	0.0188	0.0891
Trichomonas vaginalis	conserved hypothetical protein	0.0045	0.0188	0.0169
Loa Loa (eye worm)	hypothetical protein	0.004	0.0155	0.0734
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0188	0.0891
Toxoplasma gondii	calcium-dependent protein kinase CDPK2B	0.0098	0.056	0.0758
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0112	0.0657	1
Toxoplasma gondii	sugar transporter ST2	0.0045	0.0188	0.015
Trichomonas vaginalis	sugar transporter, putative	0.0045	0.0188	0.0169
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0035	0.012	0.0086
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0035	0.012	0.0372
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.004	0.0155	0.0734
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0032	0.0097	0.0097
Plasmodium vivax	lysine--tRNA ligase, putative	0.0071	0.0373	0.0298
Trichomonas vaginalis	sugar transporter, putative	0.0045	0.0188	0.0169
Toxoplasma gondii	calcium-dependent protein kinase CDPK3	0.0098	0.056	0.0758
Onchocerca volvulus		0.004	0.0155	0.0942
Onchocerca volvulus		0.0032	0.0097	0.0587
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0063	0.0312	0.0799
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0319	0.2113	0.2113
Echinococcus multilocularis	synaptic vesicle 2 protein	0.0045	0.0188	0.0188
Schistosoma mansoni	hypothetical protein	0.0048	0.0207	0.0207
Plasmodium vivax	sugar transporter, putative	0.0045	0.0188	0.0099
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0188	0.0891
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0151	0.0929	0.4395
Trichomonas vaginalis	sugar transporter, putative	0.0045	0.0188	0.0169
Trichomonas vaginalis	sugar transporter, putative	0.0099	0.0568	0.2108
Brugia malayi	hypothetical protein	0.004	0.0153	0.0723
Plasmodium vivax	calcium-dependent protein kinase 1, putative	0.0098	0.056	0.0499
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0112	0.0657	1
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0204	0.0965
Echinococcus granulosus	Sugar transporter ERD6 protein	0.0045	0.0188	0.0188
Trichomonas vaginalis	sugar transporter, putative	0.0045	0.0188	0.0169
Schistosoma mansoni	survival motor neuron protein	0.0053	0.0248	0.0248
Brugia malayi	Major Facilitator Superfamily protein	0.0045	0.0188	0.0891
Trypanosoma cruzi	hexose transporter, putative	0.0099	0.0568	0.8232
Brugia malayi	Cam kinase protein 1	0.0098	0.0559	0.2646
Echinococcus granulosus	solute carrier family 22	0.0045	0.0188	0.0188
Echinococcus granulosus	glutamyl tRNA synthetase cytoplasmic	0.0096	0.0545	0.0545
Trichomonas vaginalis	sugar transporter, putative	0.0045	0.0188	0.0169
Echinococcus multilocularis	General substrate transporter	0.0274	0.1798	0.1798
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0319	0.2113	0.2113
Trichomonas vaginalis	sugar transporter, putative	0.0045	0.0188	0.0169
Loa Loa (eye worm)	bifunctional aminoacyl-tRNA synthetase	0.0039	0.0149	0.0705
Brugia malayi	Major Facilitator Superfamily protein	0.0045	0.0188	0.0891
Echinococcus granulosus	tumor protein p63	0.0672	0.4587	0.4587
Schistosoma mansoni	hypothetical protein	0.0048	0.0207	0.0207
Echinococcus multilocularis	solute carrier family 22	0.0045	0.0188	0.0188
Loa Loa (eye worm)	beta-lactamase	0.004	0.0155	0.0734
Echinococcus granulosus	GPCR family 2	0.0048	0.0207	0.0207
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.004	0.0155	0.0307
Echinococcus granulosus	synaptic vesicle 2 protein	0.0045	0.0188	0.0188
Onchocerca volvulus		0.0045	0.0188	0.1143
Onchocerca volvulus		0.0053	0.0248	0.1506
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0204	0.0965
Echinococcus granulosus	calcium dependent protein kinase	0.0092	0.0517	0.0517
Brugia malayi	Calcium/calmodulin-dependent protein kinase type II alpha chain	0.0098	0.0559	0.2646
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0047	0.0204	0.3556
Brugia malayi	major facilitator superfamily protein	0.0045	0.0188	0.0891
Echinococcus multilocularis	solute carrier family 22	0.0045	0.0188	0.0188
Trichomonas vaginalis	sugar transporter, putative	0.0045	0.0188	0.0169
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0047	0.0204	0.1261
Onchocerca volvulus		0.0253	0.1647	1
Leishmania major	4-coumarate:coa ligase-like protein	0.0047	0.0204	0.0976
Trypanosoma brucei	glucose transporter, putative	0.0099	0.0568	0.8232
Trichomonas vaginalis	sugar transporter, putative	0.0045	0.0188	0.0169
Toxoplasma gondii	transporter, major facilitator family protein	0.0045	0.0188	0.015
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0098	0.0559	0.0559
Mycobacterium tuberculosis	Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter)	0.0045	0.0188	0.0519
Loa Loa (eye worm)	hypothetical protein	0.004	0.0155	0.0734
Mycobacterium ulcerans	integral membrane transport protein	0.0045	0.0188	0.2954
Toxoplasma gondii	ABC1 family protein	0.004	0.0155	0.0096
Trypanosoma brucei	lysyl-tRNA synthetase, putative	0.0071	0.0373	0.435
Leishmania major	glucose transporter, lmgt2	0.0099	0.0568	0.8232
Loa Loa (eye worm)	hypothetical protein	0.0035	0.012	0.057
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0045	0.0188	0.0891
Leishmania major	glucose transporter, lmgt3	0.0099	0.0568	0.8232
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.004	0.0155	0.0155
Trichomonas vaginalis	conserved hypothetical protein	0.0045	0.0188	0.0169
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0319	0.2113	0.2113
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0032	0.0097	0.0097
Onchocerca volvulus	Putative transporter	0.0045	0.0188	0.1143
Trichomonas vaginalis	sugar transporter, putative	0.0045	0.0188	0.0169
Schistosoma mansoni	protein kinase	0.0098	0.0559	0.0559
Brugia malayi	beta-lactamase family protein	0.004	0.0155	0.0734
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0188	0.0891
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.004	0.0155	0.0734
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0373	0.1766
Onchocerca volvulus		0.0045	0.0188	0.1143
Schistosoma mansoni	transcription factor LCR-F1	0.004	0.0153	0.0153
Trichomonas vaginalis	sugar transporter, putative	0.0045	0.0188	0.0169
Leishmania major	lysyl-tRNA synthetase, putative	0.0071	0.0373	0.435
Trichomonas vaginalis	sugar transporter, putative	0.0045	0.0188	0.0169
Leishmania major	myo-inositol/proton symporter (MIT)	0.0045	0.0188	0.0661
Trypanosoma cruzi	hexose transporter, putative	0.0099	0.0568	0.8232
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0031	0.0089	0.0089
Trypanosoma cruzi	hexose transporter, putative	0.0099	0.0568	0.8232
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0188	0.0891
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0098	0.0559	0.0559
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0047	0.0204	0.3556
Loa Loa (eye worm)	hypothetical protein	0.0096	0.0545	0.258
Trichomonas vaginalis	sugar transporter, putative	0.0045	0.0188	0.0169
Trypanosoma brucei	calcium/calmodulin-dependent protein kinase, putative	0.0098	0.0559	0.8057
Brugia malayi	Sugar transporter family protein	0.0319	0.2113	1
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0071	0.0373	0.1114
Plasmodium falciparum	calcium-dependent protein kinase 3	0.0098	0.056	0.0474
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0319	0.2113	0.2113
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0098	0.0559	0.0559
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0188	0.0891
Plasmodium vivax	calcium-dependent protein kinase, putative	0.0098	0.056	0.0499
Trichomonas vaginalis	conserved hypothetical protein	0.0099	0.0568	0.2108
Brugia malayi	latrophilin 2 splice variant baaae	0.0103	0.0595	0.2814
Trichomonas vaginalis	CAMK family protein kinase	0.0098	0.0559	0.2064
Trichomonas vaginalis	sugar transporter, putative	0.0045	0.0188	0.0169
Schistosoma mansoni	hypothetical protein	0.0103	0.0595	0.0595
Trichomonas vaginalis	sugar transporter, putative	0.0045	0.0188	0.0169
Onchocerca volvulus		0.0045	0.0188	0.1143
Onchocerca volvulus		0.004	0.0155	0.0942
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0096	0.0545	0.0545
Echinococcus granulosus	solute carrier family 22	0.0045	0.0188	0.0188
Toxoplasma gondii	protein kinase, putative	0.0902	0.6202	1
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0071	0.0373	1
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0047	0.0204	0.062
Echinococcus multilocularis	GPCR, family 2	0.0048	0.0207	0.0207
Plasmodium falciparum	calcium-dependent protein kinase 4	0.0098	0.056	0.0474
Mycobacterium tuberculosis	Conserved protein	0.004	0.0155	0.0307
Onchocerca volvulus		0.0045	0.0188	0.1143
Brugia malayi	Sugar transporter family protein	0.0045	0.0188	0.0891
Echinococcus multilocularis	microtubule associated protein 2	0.1444	1	1
Leishmania major	glucose transporter, lmgt1	0.0099	0.0568	0.8232
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0047	0.0204	0.062
Mycobacterium tuberculosis	Probable lipase LipE	0.004	0.0155	0.0307
Trichomonas vaginalis	sugar transporter, putative	0.0045	0.0188	0.0169
Schistosoma mansoni	tar DNA-binding protein	0.0061	0.0304	0.0304
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0098	0.0559	0.0559
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0188	0.0891
Wolbachia endosymbiont of Brugia malayi	major facilitator superfamily permease	0.0045	0.0188	0.5
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0047	0.0204	0.1261
Onchocerca volvulus		0.0045	0.0188	0.1143
Schistosoma mansoni	glucose transport protein	0.0319	0.2113	0.2113
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0032	0.0097	0.0097
Trypanosoma brucei	myo-inositol/proton symporter (MIT)	0.0045	0.0188	0.0661
Echinococcus multilocularis	beta LACTamase domain containing family member	0.004	0.0155	0.0155
Trypanosoma brucei	sugar transporter, putative	0.0045	0.0188	0.0661
Loa Loa (eye worm)	hypothetical protein	0.0035	0.012	0.057
Plasmodium falciparum	mitogen-activated protein kinase 2	0.0516	0.3493	0.3642
Toxoplasma gondii	facilitative glucose transporter GT1	0.0319	0.2113	0.3303
Plasmodium vivax	acyl-CoA synthetase, putative	0.0035	0.012	0.0025
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0071	0.0373	1
Trichomonas vaginalis	sugar transporter, putative	0.0045	0.0188	0.0169
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type 1	0.0098	0.0559	0.0559
Schistosoma mansoni	sugar transporter	0.0045	0.0188	0.0188
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0188	0.0891
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0048	0.0207	0.0207
Schistosoma mansoni	tar DNA-binding protein	0.0061	0.0304	0.0304
Trichomonas vaginalis	conserved hypothetical protein	0.0319	0.2113	1
Brugia malayi	Pre-SET motif family protein	0.0032	0.0097	0.0458
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.004	0.0155	0.0307
Echinococcus multilocularis	survival motor neuron protein 1	0.0262	0.171	0.171
Trypanosoma cruzi	lysyl-tRNA synthetase, putative	0.0071	0.0373	0.435
Brugia malayi	AMP-binding enzyme family protein	0.0047	0.0204	0.0965
Onchocerca volvulus		0.0045	0.0188	0.1143
Echinococcus multilocularis	solute carrier family 22	0.0045	0.0188	0.0188
Schistosoma mansoni	protein kinase	0.0098	0.0559	0.0559
Trypanosoma brucei	glucose transporter, putative	0.0099	0.0568	0.8232
Loa Loa (eye worm)	hypothetical protein	0.004	0.0155	0.0734
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0053	0.0248	0.1173
Echinococcus granulosus	histone lysine methyltransferase setb	0.0032	0.0097	0.0097
Echinococcus multilocularis	Sugar transporter ERD6 protein	0.0045	0.0188	0.0188
Plasmodium vivax	calcium-dependent protein kinase 4, putative	0.0098	0.056	0.0499
Trichomonas vaginalis	prolyl-tRNA synthetase, putative	0.0096	0.0545	0.1993
Echinococcus multilocularis	solute carrier family 2, facilitated glucose	0.0319	0.2113	0.2113
Entamoeba histolytica	prolyl-tRNA synthetase, putative	0.0096	0.0545	0.9658
Trichomonas vaginalis	sugar transporter, putative	0.0099	0.0568	0.2108
Echinococcus multilocularis	glutamyl tRNA synthetase cytoplasmic	0.0096	0.0545	0.0545
Schistosoma mansoni	lysyl-tRNA synthetase	0.0071	0.0373	0.0373
Echinococcus granulosus	survival motor neuron protein 1	0.0262	0.171	0.171
Loa Loa (eye worm)	hypothetical protein	0.004	0.0155	0.0734
Trypanosoma brucei	bifunctional aminoacyl-tRNA synthetase, putative	0.0112	0.0657	1
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0061	0.0304	0.1438
Schistosoma mansoni	microtubule-associated protein tau	0.1444	1	1
Echinococcus granulosus	solute carrier family 22	0.0045	0.0188	0.0188
Trichomonas vaginalis	sugar transporter, putative	0.0045	0.0188	0.0169
Onchocerca volvulus		0.0045	0.0188	0.1143
Mycobacterium tuberculosis	Probable hydrolase	0.004	0.0155	0.0307
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0151	0.0929	0.4395
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.004	0.0155	0.0307
Plasmodium vivax	proline--tRNA ligase, putative	0.0112	0.0657	0.0603
Schistosoma mansoni	glucose transport protein	0.0319	0.2113	0.2113
Brugia malayi	Bifunctional aminoacyl-tRNA synthetase	0.0096	0.0545	0.258
Toxoplasma gondii	cell-cycle-associated protein kinase MAPK, putative	0.0516	0.3493	0.5563
Leishmania major	glucose transporter/membrane transporter D2, putative	0.0099	0.0568	0.8232
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0188	0.0891
Toxoplasma gondii	sugar transporter ST1	0.0045	0.0188	0.015
Trypanosoma cruzi	hexose transporter, putative	0.0054	0.0253	0.1952
Trichomonas vaginalis	sugar transporter, putative	0.0045	0.0188	0.0169
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0188	0.0891
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0048	0.0207	0.0207
Plasmodium falciparum	hexose transporter	0.0319	0.2113	0.2152
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0047	0.0204	0.3556
Brugia malayi	AMP-binding enzyme family protein	0.0047	0.0204	0.0965
Trichomonas vaginalis	sugar transporter, putative	0.0045	0.0188	0.0169
Mycobacterium tuberculosis	Probable esterase LipL	0.004	0.0155	0.0307
Brugia malayi	major facilitator superfamily protein	0.0045	0.0188	0.0891
Mycobacterium ulcerans	sugar-transport integral membrane protein SugI	0.0045	0.0188	0.2954
Echinococcus multilocularis	lysyl tRNA synthetase	0.0071	0.0373	0.0373
Trichomonas vaginalis	sugar transporter, putative	0.0045	0.0188	0.0169
Echinococcus granulosus	tar DNA binding protein	0.0061	0.0304	0.0304
Onchocerca volvulus		0.0047	0.0204	0.1239
Plasmodium falciparum	calcium-dependent protein kinase 5	0.0098	0.056	0.0474
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0257	0.1674	1
Schistosoma mansoni	tar DNA-binding protein	0.0061	0.0304	0.0304
Trypanosoma cruzi	hexose transporter	0.0099	0.0568	0.8232
Echinococcus multilocularis	tumor protein p63	0.0672	0.4587	0.4587
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0099	0.0568	0.8232
Trichomonas vaginalis	sugar transporter, putative	0.0045	0.0188	0.0169
Schistosoma mansoni	sugar transporter	0.0045	0.0188	0.0188
Toxoplasma gondii	calcium-dependent protein kinase CDPK2A	0.0098	0.056	0.0758
Brugia malayi	lysyl-tRNA synthetase	0.0071	0.0373	0.1766
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0188	0.0891
Plasmodium falciparum	major facilitator superfamily domain-containing protein, putative	0.0045	0.0188	0.0073
Trichomonas vaginalis	myo-inositol transporter, putative	0.0045	0.0188	0.0169
Mycobacterium ulcerans	beta-lactamase	0.004	0.0155	0.1692
Loa Loa (eye worm)	sugar transporter	0.0045	0.0188	0.0891
Mycobacterium tuberculosis	Probable conserved integral membrane transport protein	0.0045	0.0188	0.0519
Onchocerca volvulus		0.0045	0.0188	0.1143
Trichomonas vaginalis	sugar transporter, putative	0.0045	0.0188	0.0169
Brugia malayi	bifunctional aminoacyl-tRNA synthetase	0.0096	0.0545	0.258
Loa Loa (eye worm)	hypothetical protein	0.0035	0.012	0.057
Leishmania major	protein kinase, putative	0.0098	0.0559	0.8057
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0188	0.0891
Onchocerca volvulus		0.0045	0.0188	0.1143
Toxoplasma gondii	lysine-tRNA ligase	0.0071	0.0373	0.0453
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0048	0.0207	0.0207
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0098	0.0559	0.0559
Plasmodium falciparum	calcium-dependent protein kinase 2	0.0098	0.056	0.0474
Onchocerca volvulus		0.0045	0.0188	0.1143
Loa Loa (eye worm)	sugar transporter	0.0319	0.2113	1
Brugia malayi	Latrophilin receptor protein 2	0.0048	0.0207	0.098
Trypanosoma brucei	glucose transporter 2A	0.0099	0.0568	0.8232
Trichomonas vaginalis	sugar transporter, putative	0.0045	0.0188	0.0169
Plasmodium falciparum	proline--tRNA ligase	0.0112	0.0657	0.0579
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0319	0.2113	0.2113
Trichomonas vaginalis	sugar transporter, putative	0.0045	0.0188	0.0169
Plasmodium falciparum	protein kinase 6	0.1356	0.9381	1
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0032	0.0097	0.0097
Echinococcus granulosus	General substrate transporter	0.0274	0.1798	0.1798
Loa Loa (eye worm)	hypothetical protein	0.0103	0.0595	0.2814
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0204	0.0965
Loa Loa (eye worm)	hypothetical protein	0.004	0.0155	0.0734
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0047	0.0204	0.1254
Schistosoma mansoni	hypothetical protein	0.0048	0.0207	0.0207
Mycobacterium leprae	Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.0061	0.0298	0.366
Schistosoma mansoni	nuclear transcription factor X-box binding 1 (nfx1)	0.0045	0.0188	0.0188
Trichomonas vaginalis	glucose transporter, putative	0.0045	0.0188	0.0169
Loa Loa (eye worm)	hypothetical protein	0.0151	0.0929	0.4395
Mycobacterium leprae	Possible lysyl-tRNA synthetase 2 LysX	0.0071	0.0373	0.5591
Loa Loa (eye worm)	hypothetical protein	0.0035	0.012	0.057
Mycobacterium ulcerans	hypothetical protein	0.0047	0.0204	0.3556
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0559	0.2646
Trypanosoma cruzi	glucose transporter, putative	0.0045	0.0188	0.0661
Mycobacterium tuberculosis	Conserved protein	0.004	0.0155	0.0307
Plasmodium falciparum	protein kinase 7	0.0902	0.6202	0.6568
Trichomonas vaginalis	sugar transporter, putative	0.0045	0.0188	0.0169
Trichomonas vaginalis	sugar transporter, putative	0.0045	0.0188	0.0169
Toxoplasma gondii	sugar transporter ST3	0.0045	0.0188	0.015
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0112	0.0657	1
Brugia malayi	AMP-binding enzyme family protein	0.0047	0.0204	0.0965
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0099	0.0568	0.8232
Schistosoma mansoni	hypothetical protein	0.0048	0.0207	0.0207
Plasmodium falciparum	calcium-dependent protein kinase 1	0.0098	0.056	0.0474
Brugia malayi	Sugar transporter family protein	0.0045	0.0188	0.0891
Onchocerca volvulus		0.0098	0.0563	0.342
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0047	0.0204	0.3556
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0188	0.0891
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0035	0.012	0.0372
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0098	0.0559	0.0559
Trypanosoma brucei	glucose transporter, putative	0.0099	0.0568	0.8232
Echinococcus multilocularis	solute carrier family 22	0.0045	0.0188	0.0188
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0048	0.0207	0.098
Loa Loa (eye worm)	RNA binding protein	0.0061	0.0304	0.1438
Trichomonas vaginalis	sugar transporter, putative	0.0045	0.0188	0.0169
Plasmodium vivax	mitogen-activated protein kinase 2, putative	0.0516	0.3493	0.3658
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0098	0.0559	0.0559
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0319	0.2113	0.2113
Entamoeba histolytica	protein kinase, putative	0.0098	0.0559	1
Brugia malayi	Major Facilitator Superfamily protein	0.0045	0.0188	0.0891

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 732050