Detailed information for compound 734684

Basic information

Technical information
  • TDR Targets ID: 734684
  • Name: 2-[(2-chloro-5-morpholin-4-ylsulfonylbenzoyl) amino]benzoic acid
  • MW: 424.855 | Formula: C18H17ClN2O6S
  • H donors: 2 H acceptors: 5 LogP: 2.24 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1cc(ccc1Cl)S(=O)(=O)N1CCOCC1)Nc1ccccc1C(=O)O
  • InChi: 1S/C18H17ClN2O6S/c19-15-6-5-12(28(25,26)21-7-9-27-10-8-21)11-14(15)17(22)20-16-4-2-1-3-13(16)18(23)24/h1-6,11H,7-10H2,(H,20,22)(H,23,24)
  • InChiKey: MFFNFAWHKMNWLV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[(2-chloro-5-morpholinosulfonyl-benzoyl)amino]benzoic acid
  • 2-[[(2-chloro-5-morpholinosulfonylphenyl)-oxomethyl]amino]benzoic acid
  • 2-[(2-chloro-5-morpholin-4-ylsulfonyl-phenyl)carbonylamino]benzoic acid
  • CBDivE_007116
  • Oprea1_077934

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni hypothetical protein 0.0063 0.0556 0.075
Echinococcus granulosus muscleblind protein 0.0459 0.4813 0.6493
Plasmodium vivax hypothetical protein, conserved 0.0147 0.1461 1
Echinococcus granulosus sodium coupled monocarboxylate transporter 1 0.0077 0.0707 0.0947
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0255 0.0336
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0037 0.0277 0.0633
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0199 0.2023 0.273
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0094 0.0885 0.1186
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0166 0.0916
Brugia malayi Calcitonin receptor-like protein seb-1 0.0199 0.2023 0.273
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0087 0.0109
Loa Loa (eye worm) hypothetical protein 0.0026 0.0157 0.0125
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0101 0.0578
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.1129 0.1449
Schistosoma mansoni ap endonuclease 0.0037 0.0277 0.0374
Chlamydia trachomatis hypothetical protein 0.0058 0.0499 1
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-6 subunit 0.0026 0.0157 0.0125
Brugia malayi GH02984p 0.07 0.7409 1
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0184 0.024
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0087 0.0109
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0087 0.0117
Brugia malayi Pre-SET motif family protein 0.0403 0.4211 0.5683
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0128 0.0074
Brugia malayi RNA, U transporter 1 0.0165 0.1653 0.2232
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0047 0.0383 0.0775
Loa Loa (eye worm) hypothetical protein 0.002 0.0087 0.003
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0128 0.0173
Loa Loa (eye worm) hypothetical protein 0.002 0.0087 0.003
Schistosoma mansoni hypothetical protein 0.0012 0.0006 0.0009
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0606 0.64 0.8626
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0093 0.0874 0.1102
Schistosoma mansoni serine/threonine protein kinase 0.0093 0.0874 0.1179
Entamoeba histolytica hypothetical protein 0.0047 0.0383 0.1012
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0058 0.0498 0.3331
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0166 0.1032
Loa Loa (eye worm) hypothetical protein 0.0026 0.0157 0.0125
Brugia malayi steroid hormone receptor 0.002 0.0087 0.0117
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0184 0.024
Echinococcus multilocularis sodium:glucose cotransporter 2 0.0077 0.0707 0.0947
Trichomonas vaginalis GTP-binding protein (q) alpha-11 subunit, gna11, putative 0.0026 0.0157 0.0303
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0606 0.64 0.8637
Loa Loa (eye worm) hypothetical protein 0.0023 0.0128 0.0087
Brugia malayi Pre-SET motif family protein 0.0058 0.0498 0.0672
Mycobacterium tuberculosis Conserved protein 0.0147 0.1461 0.1414
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0606 0.64 0.8637
Loa Loa (eye worm) hypothetical protein 0.0058 0.0501 0.0595
Onchocerca volvulus 0.0147 0.1461 0.291
Mycobacterium ulcerans hypothetical protein 0.0058 0.0499 0.3111
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0184 0.1158
Plasmodium falciparum histone acetyltransferase GCN5 0.012 0.1172 1
Echinococcus granulosus peregrin 0.004 0.0302 0.0399
Echinococcus multilocularis sodium:myo inositol cotransporter 0.0077 0.0707 0.0947
Loa Loa (eye worm) latrophilin receptor protein 2 0.0063 0.0556 0.0668
Loa Loa (eye worm) hypothetical protein 0.0147 0.1461 0.1901
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0058 0.0498 0.0672
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0874 0.1797
Entamoeba histolytica serine/threonine protein kinase, putative 0.0093 0.0874 0.2768
Loa Loa (eye worm) hypothetical protein 0.07 0.7409 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0063 0.0556 0.0742
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0128 0.0456
Loa Loa (eye worm) hypothetical protein 0.002 0.0087 0.003
Loa Loa (eye worm) beta-lactamase 0.0147 0.1461 0.1901
Toxoplasma gondii hypothetical protein 0.0058 0.0499 0.3338
Brugia malayi hypothetical protein 0.0027 0.0166 0.0224
Trichomonas vaginalis D-aminoacylase, putative 0.0147 0.1461 0.3022
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0184 0.1158
Giardia lamblia Kinase, PLK 0.0093 0.0874 0.2768
Schistosoma mansoni family U48 unassigned peptidase (U48 family) 0.028 0.2894 0.3906
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0128 0.01
Plasmodium falciparum phd finger protein, putative 0.0029 0.0184 0.108
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0087 0.0109
Loa Loa (eye worm) hypothetical protein 0.0459 0.4813 0.6465
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0087 0.0117
Toxoplasma gondii transporter, solute:sodium symporter (SSS) family protein 0.0077 0.0707 0.478
Trypanosoma cruzi CAAX prenyl protease 2, putative 0.028 0.2894 1
Schistosoma mansoni hypothetical protein 0.0035 0.0255 0.0345
Brugia malayi MH2 domain containing protein 0.0116 0.1129 0.1524
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0255 0.0345
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0037 0.0277 0.1523
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0087 0.0117
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0093 0.0874 0.1172
Mycobacterium leprae conserved hypothetical protein 0.0147 0.1461 1
Echinococcus multilocularis geminin 0.069 0.7297 0.985
Loa Loa (eye worm) hypothetical protein 0.0029 0.0184 0.0163
Entamoeba histolytica hypothetical protein 0.0035 0.0255 0.0554
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0087 0.0117
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0087 0.003
Schistosoma mansoni high-affinity choline transporter 0.07 0.7409 1
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0128 0.0456
Trichomonas vaginalis ran, putative 0.0021 0.0101 0.0186
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0087 0.0117
Plasmodium vivax SET domain protein, putative 0.0058 0.0498 0.3331
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0087 0.0109
Schistosoma mansoni inositol transporter 0.0077 0.0707 0.0955
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.0065 0.001
Echinococcus multilocularis solute carrier family 5 0.0077 0.0707 0.0947
Toxoplasma gondii exonuclease III APE 0.0037 0.0277 0.1802
Echinococcus granulosus GPCR family 2 0.0063 0.0556 0.0742
Loa Loa (eye worm) hypothetical protein 0.0049 0.0404 0.0462
Echinococcus granulosus histone acetyltransferase KAT2B 0.0434 0.4548 0.6135
Onchocerca volvulus 0.0026 0.0157 0.0148
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0026 0.0157 0.0303
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0184 0.1158
Loa Loa (eye worm) hypothetical protein 0.0147 0.1461 0.1901
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0063 0.0556 0.0742
Entamoeba histolytica hypothetical protein 0.0035 0.0255 0.0554
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0037 0.0277 0.0633
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0026 0.0157 0.0203
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.0166 0.1032
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0026 0.0157 0.0303
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0087 0.0109
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0087 0.0109
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.1129 0.1449
Onchocerca volvulus 0.0023 0.0128 0.0088
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0087 0.003
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0277 0.0555
Trichomonas vaginalis GTP-binding protein (z) alpha subunit, gnaz, putative 0.0026 0.0157 0.0303
Loa Loa (eye worm) hypothetical protein 0.002 0.0087 0.003
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0147 0.1461 0.1901
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0087 0.0117
Mycobacterium ulcerans hypothetical protein 0.0023 0.0128 0.0456
Brugia malayi beta-lactamase family protein 0.0147 0.1461 0.1972
Brugia malayi guanine nucleotide-binding protein alpha-3 subunit, putative 0.0026 0.0157 0.0212
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0063 0.0556 0.0742
Schistosoma mansoni jumonji/arid domain-containing protein 0.0035 0.0249 0.0336
Schistosoma mansoni GTP-binding protein alpha subunit 0.0026 0.0157 0.0212
Onchocerca volvulus 0.0147 0.1461 0.291
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0147 0.1461 0.1972
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0026 0.0157 0.0212
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0087 0.0109
Echinococcus granulosus CAAX prenyl protease 2 0.028 0.2894 0.3901
Brugia malayi Guanine nucleotide-binding protein alpha-12 subunit, putative 0.0026 0.0157 0.0212
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0058 0.0498 0.0664
Trichomonas vaginalis importin beta-1, putative 0.0047 0.0383 0.0775
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0026 0.0157 0.0212
Entamoeba histolytica CAAX prenyl protease family 0.028 0.2894 1
Plasmodium vivax importin-beta 2, putative 0.0058 0.0501 0.3353
Loa Loa (eye worm) hypothetical protein 0.0459 0.4813 0.6465
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0058 0.0498 0.0664
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0147 0.1461 0.1972
Schistosoma mansoni thyroid hormone receptor 0.002 0.0087 0.0117
Trypanosoma cruzi polo-like protein kinase, putative 0.0093 0.0874 0.2768
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0087 0.0109
Brugia malayi nuclear receptor NHR-88 0.002 0.0087 0.0117
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0277 0.1802
Brugia malayi jmjC domain containing protein 0.0094 0.0885 0.1194
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.037 0.0748
Brugia malayi beta-lactamase family protein 0.0147 0.1461 0.1972
Trichomonas vaginalis set domain proteins, putative 0.0458 0.4809 1
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0093 0.0874 0.1172
Schistosoma mansoni GTP-binding protein alpha subunit 0.0026 0.0157 0.0212
Brugia malayi guanine nucleotide-binding protein alpha-7 subunit, putative 0.0026 0.0157 0.0212
Schistosoma mansoni hypothetical protein 0.0136 0.1344 0.1814
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0087 0.0109
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0087 0.0109
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0058 0.0498 0.0672
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0087 0.0117
Mycobacterium tuberculosis Probable esterase LipL 0.0147 0.1461 0.1414
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0047 0.0383 0.0775
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0128 0.01
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0447 0.4683 0.6321
Brugia malayi acetyltransferase, GNAT family protein 0.0447 0.4683 0.6321
Mycobacterium tuberculosis Conserved hypothetical protein 0.0058 0.0499 0.0447
Mycobacterium tuberculosis Probable conserved integral membrane protein 0.0058 0.0499 0.0447
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0147 0.1461 0.1414
Loa Loa (eye worm) hypothetical protein 0.0027 0.0166 0.0138
Brugia malayi guanine nucleotide-binding protein G-o protein alpha subunit 0.0026 0.0157 0.0212
Loa Loa (eye worm) hypothetical protein 0.0147 0.1461 0.1901
Mycobacterium ulcerans esterase/lipase LipP 0.0147 0.1461 1
Schistosoma mansoni hypothetical protein 0.0063 0.0556 0.075
Trichomonas vaginalis bromodomain-containing protein, putative 0.0131 0.129 0.2665
Treponema pallidum hypothetical protein 0.0058 0.0499 1
Echinococcus granulosus jumonji domain containing protein 0.004 0.0305 0.0403
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0128 0.01
Brugia malayi hypothetical protein 0.0026 0.0157 0.0212
Brugia malayi hypothetical protein 0.0017 0.0064 0.0086
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0128 0.0456
Echinococcus granulosus snurportin 1 0.062 0.6547 0.8836
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0087 0.0117
Schistosoma mansoni jumonji/arid domain-containing protein 0.0035 0.0249 0.0336
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0026 0.0157 0.0203
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0255 0.0336
Brugia malayi Importin beta-1 subunit 0.0058 0.0501 0.0677
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0131 0.129 0.2665
Echinococcus granulosus importin subunit beta 1 0.0058 0.0501 0.0669
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0037 0.0277 0.0633
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0131 0.129 0.8815
Loa Loa (eye worm) hypothetical protein 0.002 0.0087 0.003
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0037 0.0277 0.0633
Brugia malayi nuclear hormone receptor 0.002 0.0087 0.0117
Echinococcus granulosus beta LACTamase domain containing family member 0.0147 0.1461 0.1965
Schistosoma mansoni hypothetical protein 0.062 0.6547 0.8837
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0101 0.0324
Onchocerca volvulus Alhambra homolog 0.0029 0.0184 0.0206
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0058 0.0498 0.0672
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0447 0.4683 0.6318
Loa Loa (eye worm) acetyltransferase 0.0447 0.4683 0.6288
Plasmodium vivax protease, putative 0.0058 0.0499 0.3338
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0087 0.0109
Echinococcus granulosus sodium:myo inositol cotransporter 0.0077 0.0707 0.0947
Entamoeba histolytica G protein alpha subunit, putative 0.0026 0.0157 0.0201
Brugia malayi Sodium:solute symporter family protein 0.0077 0.0707 0.0955
Loa Loa (eye worm) G protein alpha subunit 3 0.0026 0.0157 0.0125
Toxoplasma gondii HEAT repeat-containing protein 0.0058 0.0501 0.3353
Echinococcus multilocularis muscleblind protein 1 0.0459 0.4813 0.6493
Loa Loa (eye worm) hypothetical protein 0.0063 0.0556 0.0668
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0037 0.0277 0.0366
Mycobacterium ulcerans beta-lactamase 0.0147 0.1461 1
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0101 0.0136
Echinococcus multilocularis high affinity choline transporter 1 0.07 0.7409 1
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0026 0.0157 0.0212
Loa Loa (eye worm) hypothetical protein 0.0147 0.1461 0.1901
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0199 0.2023 0.2666
Plasmodium falciparum importin beta, putative 0.0058 0.0501 0.3943
Echinococcus multilocularis gtp binding protein (I) alpha 1subunit 0.0026 0.0157 0.0203
Toxoplasma gondii hypothetical protein 0.0058 0.0499 0.3338
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0087 0.0109
Loa Loa (eye worm) hypothetical protein 0.0026 0.0157 0.0125
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0087 0.0117
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0147 0.1461 0.1414
Leishmania major importin beta-1 subunit, putative 0.0047 0.0383 0.1012
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0093 0.0874 0.2768
Schistosoma mansoni hypothetical protein 0.0063 0.0556 0.075
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0037 0.0277 0.5
Loa Loa (eye worm) jmjC domain-containing protein 0.0035 0.0249 0.0251
Brugia malayi PHD-finger family protein 0.0029 0.0184 0.0249
Trichomonas vaginalis D-aminoacylase, putative 0.0147 0.1461 0.3022
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0128 0.01
Giardia lamblia PHD finger protein 15 0.0029 0.0184 0.03
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0026 0.0157 0.0212
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0087 0.0117
Trichomonas vaginalis penicillin-binding protein, putative 0.0147 0.1461 0.3022
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0037 0.0277 0.0633
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0087 0.0117
Loa Loa (eye worm) hypothetical protein 0.0199 0.2023 0.2666
Entamoeba histolytica hypothetical protein 0.0035 0.0255 0.0554
Loa Loa (eye worm) hypothetical protein 0.0147 0.1461 0.1901
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0277 0.0555
Trypanosoma brucei importin beta-1 subunit, putative 0.0058 0.0501 0.1435
Giardia lamblia Hypothetical protein 0.028 0.2894 1
Onchocerca volvulus Serine\/threonine kinase homolog 0.0093 0.0874 0.1666
Giardia lamblia Histone acetyltransferase GCN5 0.012 0.1172 0.3836
Trypanosoma cruzi hypothetical protein, conserved 0.0147 0.1461 0.487
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0037 0.0277 0.029
Loa Loa (eye worm) hypothetical protein 0.028 0.2894 0.3852
Schistosoma mansoni importin beta-1 0.0058 0.0501 0.0677
Echinococcus granulosus solute carrier family 5 0.0077 0.0707 0.0947
Mycobacterium tuberculosis Probable lipase LipE 0.0147 0.1461 0.1414
Echinococcus multilocularis thyroid hormone receptor alpha 0.002 0.0087 0.0109
Mycobacterium tuberculosis Conserved protein 0.0147 0.1461 0.1414
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0087 0.0117
Trichomonas vaginalis Clan U, family U48, CaaX prenyl peptidase 2-like 0.028 0.2894 0.6008
Echinococcus granulosus histone acetyltransferase KAT2B 0.0131 0.129 0.1734
Schistosoma mansoni ran 0.0021 0.0101 0.0136
Echinococcus granulosus expressed protein 0.0026 0.0157 0.0203
Onchocerca volvulus 0.0026 0.0157 0.0148
Echinococcus multilocularis importin subunit beta 1 0.0058 0.0501 0.0669
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0184 0.0249
Echinococcus granulosus FTZ F1 alpha 0.002 0.0087 0.0109
Mycobacterium tuberculosis Probable conserved integral membrane protein 0.0058 0.0499 0.0447
Brugia malayi exodeoxyribonuclease III family protein 0.0037 0.0277 0.0374
Trypanosoma brucei polo-like protein kinase 0.0093 0.0874 0.2768
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0087 0.0117
Entamoeba histolytica hypothetical protein 0.0035 0.0255 0.0554
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0131 0.129 0.8815
Brugia malayi CAAX amino terminal protease family protein 0.028 0.2894 0.3906
Brugia malayi latrophilin 2 splice variant baaae 0.0136 0.1344 0.1814
Mycobacterium tuberculosis Probable lipase LipD 0.0147 0.1461 0.1414
Trypanosoma brucei importin beta-1 subunit, putative 0.0058 0.0501 0.1435
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0026 0.0157 0.0212
Schistosoma mansoni ap endonuclease 0.0037 0.0277 0.0374
Onchocerca volvulus 0.0458 0.4809 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0606 0.64 0.8637
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0026 0.0157 0.0303
Mycobacterium ulcerans lipase LipD 0.0147 0.1461 1
Brugia malayi GTP-binding regulatory protein alpha chain - starfish, putative 0.0026 0.0157 0.0212
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0087 0.003
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0087 0.0117
Echinococcus multilocularis muscleblind protein 0.0459 0.4813 0.6493
Brugia malayi beta-lactamase 0.0147 0.1461 0.1972
Echinococcus multilocularis CAAX prenyl protease 2 0.028 0.2894 0.3901
Brugia malayi G-protein alpha subunit 0.0026 0.0157 0.0212
Schistosoma mansoni ran 0.0021 0.0101 0.0136
Schistosoma mansoni sodium/solute symporter 0.0077 0.0707 0.0955
Echinococcus multilocularis beta LACTamase domain containing family member 0.0147 0.1461 0.1965
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0606 0.64 0.8638
Entamoeba histolytica CAAX amino terminal protease family 0.0058 0.0499 0.1427
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0128 0.0456
Trichomonas vaginalis penicillin-binding protein, putative 0.0147 0.1461 0.3022
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0874 0.1797
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0087 0.0117
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0874 0.1797
Schistosoma mansoni hypothetical protein 0.069 0.7297 0.985
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0037 0.0277 0.0224
Mycobacterium ulcerans integral membrane protein 0.0058 0.0499 0.3111
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0128 0.0173
Echinococcus granulosus sodium:glucose cotransporter 0.0077 0.0707 0.0947
Echinococcus granulosus sodium:glucose cotransporter 2 0.0077 0.0707 0.0947
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0087 0.0117
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0606 0.64 0.8638
Schistosoma mansoni jumonji domain containing protein 0.0074 0.0677 0.0914
Schistosoma mansoni thyroid hormone receptor 0.002 0.0087 0.0117
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0063 0.0556 0.075
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0026 0.0157 0.0212
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0131 0.129 0.8815
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0087 0.003
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0026 0.0157 0.0212
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0087 0.0117
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0026 0.0157 0.0203
Plasmodium vivax acyl-CoA synthetase, putative 0.0017 0.0065 0.0329
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0166 0.0235
Loa Loa (eye worm) hypothetical protein 0.0147 0.1461 0.1901
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0087 0.0117
Brugia malayi serine/threonine-protein kinase plk-2 0.0093 0.0874 0.1179
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-12 subunit 0.0026 0.0157 0.0125
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0128 0.01
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0101 0.0127
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0087 0.0109
Schistosoma mansoni family U48 unassigned peptidase (U48 family) 0.028 0.2894 0.3906
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0087 0.0117
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0101 0.0049
Toxoplasma gondii ABC1 family protein 0.0147 0.1461 1
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0026 0.0157 0.0203
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0305 0.0403
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0166 0.0916
Echinococcus granulosus gtp binding protein I alpha 1subunit 0.0026 0.0157 0.0203
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0147 0.1461 0.1414
Brugia malayi hypothetical protein 0.0035 0.0255 0.0345
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0147 0.1461 0.1972
Mycobacterium tuberculosis Conserved protein 0.0147 0.1461 0.1414
Entamoeba histolytica acetyltransferase, GNAT family 0.012 0.1172 0.3836
Mycobacterium ulcerans hypothetical protein 0.0058 0.0499 0.3111
Loa Loa (eye worm) heterotrimeric G protein alpha subunit 0.0026 0.0157 0.0125
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0087 0.0109
Trichomonas vaginalis G protein (olf) alpha subunit, gnal, putative 0.0026 0.0157 0.0303
Leishmania major hypothetical protein, conserved 0.0147 0.1461 0.487
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0874 0.1797
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0037 0.0277 0.0633
Trichomonas vaginalis esterase, putative 0.0147 0.1461 0.3022
Loa Loa (eye worm) hypothetical protein 0.0026 0.0157 0.0125
Echinococcus multilocularis snurportin 1 0.062 0.6547 0.8836
Loa Loa (eye worm) GTP-binding regulatory protein alpha chain 0.0026 0.0157 0.0125
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0026 0.0157 0.0303
Loa Loa (eye worm) hypothetical protein 0.0026 0.0157 0.0125
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0101 0.0127
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0026 0.0157 0.0212
Echinococcus multilocularis GPCR, family 2 0.0063 0.0556 0.0742
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0087 0.0117
Schistosoma mansoni nuclear hormone receptor 0.002 0.0087 0.0117
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0277 0.192
Trypanosoma cruzi peptidase with unknown catalytic mechanism (family U48) 0.028 0.2894 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.0512 0.0609
Echinococcus granulosus lysine specific demethylase 5A 0.0035 0.0249 0.0328
Trichomonas vaginalis D-aminoacylase, putative 0.0147 0.1461 0.3022
Loa Loa (eye worm) hypothetical protein 0.0077 0.0707 0.0875
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0087 0.0117
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0087 0.0109
Trypanosoma cruzi polo-like protein kinase, putative 0.0093 0.0874 0.2768
Schistosoma mansoni inositol transporter 0.0077 0.0707 0.0955
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0184 0.0163
Echinococcus granulosus high affinity choline transporter 1 0.07 0.7409 1
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.0166 0.0235
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0087 0.0109
Entamoeba histolytica CAAX amino terminal protease family 0.0058 0.0499 0.1427
Mycobacterium leprae Probable lipase LipE 0.0147 0.1461 1
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0026 0.0157 0.0203
Loa Loa (eye worm) hypothetical protein 0.002 0.0087 0.003
Plasmodium falciparum protease, putative 0.0058 0.0499 0.3923
Mycobacterium ulcerans hypothetical protein 0.0147 0.1461 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0058 0.0498 0.0672
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0026 0.0157 0.0203
Brugia malayi Latrophilin receptor protein 2 0.0063 0.0556 0.075
Echinococcus granulosus geminin 0.069 0.7297 0.985
Trichomonas vaginalis GTP-binding protein (O) alpha subunit, gnao, putative 0.0026 0.0157 0.0303
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0128 0.01
Trypanosoma brucei hypothetical protein, conserved 0.0147 0.1461 0.487
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0087 0.003
Leishmania major hypothetical protein, conserved 0.0027 0.0166 0.0235
Onchocerca volvulus 0.0026 0.0157 0.0148
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0087 0.003
Loa Loa (eye worm) hypothetical protein 0.002 0.0087 0.003
Toxoplasma gondii CAAX amino terminal protease family protein 0.0058 0.0499 0.3338
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0128 0.0456
Loa Loa (eye worm) hypothetical protein 0.0136 0.1344 0.1741
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0056 0.0475 0.0633
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0087 0.003
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.037 0.0748
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0166 0.0235
Echinococcus multilocularis sodium coupled monocarboxylate transporter 1 0.0077 0.0707 0.0947
Schistosoma mansoni trimeric G-protein alpha o subunit 0.0026 0.0157 0.0212
Schistosoma mansoni kinase 0.0047 0.0383 0.0517
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0087 0.0117
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0026 0.0157 0.0212
Brugia malayi Muscleblind-like protein 0.0459 0.4813 0.6496
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0087 0.0117
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0087 0.003
Mycobacterium tuberculosis Probable integral membrane protein 0.0058 0.0499 0.0447
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0128 0.0456
Onchocerca volvulus 0.0058 0.0498 0.0871
Echinococcus multilocularis peregrin 0.004 0.0302 0.0399
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0606 0.64 0.8638
Schistosoma mansoni hypothetical protein 0.0029 0.0184 0.0249
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0087 0.0117
Brugia malayi guanine nucleotide-binding protein G(o), alpha subunit, putative 0.0026 0.0157 0.0212
Echinococcus multilocularis lysine specific demethylase 5A 0.0035 0.0249 0.0328
Onchocerca volvulus 0.0147 0.1461 0.291
Schistosoma mansoni coup transcription factor 0.002 0.0087 0.0117
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0026 0.0157 0.0212
Loa Loa (eye worm) hypothetical protein 0.0023 0.0128 0.0087
Trypanosoma cruzi importin beta-1 subunit, putative 0.0047 0.0383 0.1012
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0128 0.0456
Schistosoma mansoni hypothetical protein 0.069 0.7297 0.985
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0087 0.0117
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0026 0.0157 0.0203
Onchocerca volvulus 0.0077 0.0707 0.1314
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0874 0.1797
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0128 0.0074
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0094 0.0885 0.1186
Loa Loa (eye worm) hypothetical protein 0.0058 0.0498 0.059
Brugia malayi jmjC domain containing protein 0.0035 0.0249 0.0336
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.062 0.6547 0.8826
Echinococcus multilocularis expressed protein 0.0026 0.0157 0.0203
Loa Loa (eye worm) hypothetical protein 0.0023 0.0128 0.0087
Echinococcus granulosus histone lysine methyltransferase setb 0.0058 0.0498 0.0664
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0128 0.0173
Mycobacterium tuberculosis Probable hydrolase 0.0147 0.1461 0.1414
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0147 0.1461 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0087 0.003
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0026 0.0157 0.0212
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0037 0.0277 0.0366
Brugia malayi Bromodomain containing protein 0.004 0.0302 0.0408
Brugia malayi ecdysteroid receptor 0.002 0.0087 0.0117
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0606 0.64 0.8638
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0101 0.0578
Trypanosoma brucei CAAX amino terminal protease, putative 0.028 0.2894 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0403 0.4211 0.5645
Schistosoma mansoni hypothetical protein 0.0063 0.0556 0.075
Schistosoma mansoni GTP-binding protein (I) alpha subunit gnai 0.0026 0.0157 0.0212
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0026 0.0157 0.0203
Trypanosoma cruzi hypothetical protein, conserved 0.0147 0.1461 0.487
Leishmania major CAAX prenyl protease 2, putative,peptidase with unknown catalytic mechanism (family U48) 0.028 0.2894 1
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0874 0.1797
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0606 0.64 0.8637
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0063 0.0556 0.0742
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0874 0.1797
Brugia malayi Guanine nucleotide-binding protein alpha-6 subunit, putative 0.0026 0.0157 0.0212

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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