Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | angiotensin II receptor, type 2 | Starlite/ChEMBL | No references |
Bos taurus | Angiotensin II type 1a (AT-1a) receptor | Starlite/ChEMBL | No references |
Homo sapiens | angiotensin II receptor, type 1 | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | glucosylceramidase, putative | 0.0166 | 0.2154 | 0.4741 |
Loa Loa (eye worm) | hypothetical protein | 0.0186 | 0.2561 | 0.2555 |
Echinococcus multilocularis | fucosidase, alpha L 1, tissue | 0.0463 | 0.8046 | 1 |
Mycobacterium ulcerans | alpha-L-fucosidase | 0.0463 | 0.8046 | 0.5 |
Onchocerca volvulus | Glucosylceramidase homolog | 0.0166 | 0.2154 | 0.5 |
Trichomonas vaginalis | alpha-L-fucosidase, putative | 0.0123 | 0.1306 | 0.2362 |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.0465 | 0.0458 |
Loa Loa (eye worm) | alpha-L-fucosidase | 0.028 | 0.4419 | 0.4415 |
Toxoplasma gondii | melibiase subfamily protein | 0.008 | 0.0465 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0252 | 0.3873 | 0.9567 |
Schistosoma mansoni | alpha-l-fucosidase | 0.028 | 0.4419 | 1 |
Echinococcus granulosus | fucosidase alpha L 1 tissue | 0.0463 | 0.8046 | 1 |
Echinococcus granulosus | beta galactosidase | 0.0186 | 0.2561 | 0.2765 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0166 | 0.2154 | 0.4741 |
Trichomonas vaginalis | alpha-L-fucosidase, putative | 0.0123 | 0.1306 | 0.2362 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0174 | 0.2331 | 0.5237 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0252 | 0.3873 | 0.9567 |
Brugia malayi | O-Glycosyl hydrolase family 30 protein | 0.0252 | 0.3873 | 0.8763 |
Entamoeba histolytica | beta-galactosidase, putative | 0.011 | 0.1054 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0252 | 0.3873 | 0.9567 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0252 | 0.3873 | 0.9567 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0163 | 0.21 | 0.4591 |
Trichomonas vaginalis | beta-galactosidase, putative | 0.0163 | 0.21 | 0.4591 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0252 | 0.3873 | 0.9567 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0166 | 0.2154 | 0.4741 |
Brugia malayi | Alpha-L-fucosidase family protein | 0.028 | 0.4419 | 1 |
Echinococcus multilocularis | beta galactosidase | 0.0186 | 0.2561 | 0.2765 |
Trichomonas vaginalis | glycoside hydrolases, putative | 0.0142 | 0.1687 | 0.343 |
Brugia malayi | Melibiase family protein | 0.008 | 0.0465 | 0.1037 |
Trichomonas vaginalis | beta-glucosidase, putative | 0.0142 | 0.1687 | 0.343 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0174 | 0.2331 | 0.5237 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0166 | 0.2154 | 0.4741 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0166 | 0.2154 | 0.4741 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0252 | 0.3873 | 0.9567 |
Loa Loa (eye worm) | O-glycosyl hydrolase family 30 protein | 0.0252 | 0.3873 | 0.3869 |
Trichomonas vaginalis | glycoside hydrolase, putative | 0.026 | 0.4028 | 1 |
Schistosoma mansoni | beta-galactosidase | 0.0186 | 0.2561 | 0.53 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0166 | 0.2154 | 0.4741 |
Plasmodium vivax | hypothetical protein, conserved | 0.0057 | 0 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0166 | 0.2154 | 0.4741 |
Plasmodium falciparum | conserved Plasmodium protein, unknown function | 0.0057 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0154 | 0.1935 | 0.3717 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 120 nM | Ability of the compound to displace [125I]- labelled [Sar1,Ileu8] from angiotensin II receptor of bovine adrenal cortex membranes | ChEMBL. | No reference |
IC50 (binding) | = 120 nM | Ability of the compound to displace [125I]- labelled [Sar1,Ileu8] from angiotensin II receptor of bovine adrenal cortex membranes | ChEMBL. | No reference |
Kd (functional) | = 7.5 | Inhibition of angiotensin II induced contraction in thoracic aortic rings from New Zealand rabbits | ChEMBL. | No reference |
pA2 (functional) | = 7.5 | Inhibition of angiotensin II induced contraction in thoracic aortic rings from New Zealand rabbits | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.